keyword
https://read.qxmd.com/read/38196572/nomogram-for-predicting-bleeding-events-in-nonvalvular-atrial-fibrillation-patients-receiving-rivaroxaban-a-retrospective-study
#1
JOURNAL ARTICLE
Chang Cao, Yijiao Xu, Weiwen Jiang, Shujing Wu, Yun Shen, Xiaotong Xia, Lumin Wang, Huijun Zhang, Hongni Jiang, Xiaoyu Li, Xiaoye Li, Yanrong Ye
BACKGROUND AND AIMS: To construct a bleeding events prediction model of nonvalvular atrial fibrillation (NVAF) patients receiving rivaroxaban. METHODS: We conducted a retrospective cohort study in patients with NVAF who received rivaroxaban from June 2017 to March 2019. Demographic information and clinical characteristics were obtained from the electronic medical system. Univariate analysis was used to find the primary predictive factors of bleeding events in patients receiving rivaroxaban...
January 2024: Health Science Reports
https://read.qxmd.com/read/38168895/left-atrial-appendage-occlusion-in-patients-suffering-from-advanced-chronic-kidney-disease-stage-4-and-5-long-term-follow-up
#2
JOURNAL ARTICLE
Sergio López-Tejero, Pablo Antúnez-Muiños, Pilar Fraile-Gómez, Gilles Barreira-de Sousa, Javier Rodríguez-Collado, Jesús Herrero-Garibi, Fabián Blanco-Fernández, Alejandro Diego-Nieto, Gonzalo C Delgado-Lapeira, M Candelas Pérez Del Villar-Moro, Javier Martín-Moreiras, Pedro L Sánchez-Fernández, Ignacio Cruz-González
INTRODUCTION AND OBJECTIVES: Advanced chronic kidney disease (A-CKD) combined with atrial fibrillation increases the risk of both thrombogenic and bleeding events. Left atrial appendage occlusion (LAAO) may be an alternative to oral anticoagulation to prevent thromboembolic events. We aimed to evaluate the outcomes of LAAO in patients with A-CKD. METHODS: Comparison at long-term follow-up of patients diagnosed with and without A-CKD (eGFR<30 mL/min/1.73 m2 ) who underwent LAAO between 2009 and May 2022...
January 3, 2024: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/38137793/relationship-between-pharmacological-treatment-strategy-and-cognitive-function-in-geriatric-patients-with-atrial-fibrillation
#3
JOURNAL ARTICLE
Markus Goetze, Tim Knauf, Henning Ebelt
UNLABELLED: Background and question: Atrial fibrillation (AF) is the most common cardiac arrhythmia in the total population. The aim of this study is to determine how geriatric patients with AF are treated in terms of rhythm or rate control and whether a relationship between the type of treatment and Mini Mental Status (MMS) can be identified. METHODS: In this monocentric, prospective, observational study, data including chronic medication as well as demographic parameters were collected from all patients in a geriatric department between April 2021 and April 2022...
December 16, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38097269/pharmacist-led-interventions-in-optimising-the-use-of-oral-anticoagulants-in-atrial-fibrillation-patients-in-the-general-practice-in-england-a-retrospective-observational-study
#4
JOURNAL ARTICLE
Raman Sharma, Syed Shahzad Hasan, Ishtiaq A Gilkar, Waheed F Hussain, Barbara R Conway, Muhammad Usman Ghori
BACKGROUND: Oral anticoagulation (OAC) is the mainstay of treatment for the prevention of strokes in patients with atrial fibrillation (AF). Direct oral anticoagulants (DOACs) account for increasing OAC in AF patients. However, prescribing DOACs for patients with established AF poses various challenges and general practice pharmacists may have an important role in supporting their management. AIM: Investigating the effectiveness of pharmacist-led interventions in general practice in optimising the use of OAC therapies in AF...
December 14, 2023: BJGP Open
https://read.qxmd.com/read/37962263/left-atrial-appendage-occlusion-for-atrial-fibrillation-and-bleeding-diathesis
#5
JOURNAL ARTICLE
Balrik Singh Kailey, Michael Koa-Wing, Nilesh Sutaria, Tom Mott, Afzal Sohaib, Norman Qureshi, Christine Shi, Pritpal Padam, James Howard, Prapa Kanagaratnam
BACKGROUND: Patients with atrial fibrillation (AF) and likelihood of bleeding can undergo left atrial appendage occlusion (LAAO) as an alternative method of stroke prophylaxis. Short-term anti-thrombotic drugs are used postprocedure to offset the risk of device-related thrombus, evidence for this practice is limited. OBJECTIVES: To investigate optimal postimplant antithrombotic strategy in high bleeding-risk patients. METHODS: Patients with AF and high-risk for both stroke and bleeding undergoing LAAO were advised their perioperative drug therapy by a multidisciplinary physician panel...
November 14, 2023: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/37901163/serial-changes-in-the-trends-of-direct-oral-anticoagulant-use-and-incidence-of-thromboembolisms-and-major-bleeding-events-in-very-old-patients-with-non-valvular-atrial-fibrillation
#6
JOURNAL ARTICLE
Masahiko Takahashi, Takeshi Morimoto, Ryu Tsushima, Yuya Sudo, Ai Sakamoto, Masahiro Sogo, Masatomo Ozaki, Keisuke Okawa
AIMS: Direct oral anticoagulants (DOACs) have become the first-line antithrombotic therapy in patients with non-valvular atrial fibrillation (NVAF). During this period, the incidence of thromboembolisms and major bleeding events has decreased. However, no studies have shown a correlation between them, and even fewer data are available on older patients. Therefore, we evaluated the serial changes in oral anticoagulant (OAC) use and the correlation between DOAC use and the incidence of adverse events among very old patients with NVAF...
September 2023: Eur Heart J Open
https://read.qxmd.com/read/37840634/predictive-value-of-bleeding-risk-scores-in-elderly-patients-with-atrial-fibrillation-and-oral-anticoagulation
#7
JOURNAL ARTICLE
Pablo Domínguez-Erquicia, Sergio Raposeiras-Roubín, Emad Abu-Assi, Andrea Lizancos-Castro, Jose A Parada-Barcia, André González-García, Ana Ledo-Piñeiro, Vanesa Noriega-Caro, Carla Iglesias-Otero, Andrés Íñiguez-Romo
BACKGROUND: The predictive value of bleeding risk scores for atrial fibrillation in older patients is not as well known. The goal of this study was to evaluate the predictive value of HASBLED, ORBIT and ATRIA for major bleeding (MB) and intracranial hemorrhage (ICH) in patients ≥ 75 years with atrial fibrillation and oral anticoagulation (OAC). METHODS: A retrospective unicenter study including patients ≥ 75 years with atrial fibrillation (AF) and OAC...
September 28, 2023: Journal of Geriatric Cardiology: JGC
https://read.qxmd.com/read/37801642/characteristics-of-patients-with-atrial-fibrillation-treated-with-direct-oral-anticoagulants-and-new-insights-into-inappropriate-dosing-results-from-the-french-national-paf-registry
#8
JOURNAL ARTICLE
M Guenoun, S Cohen, M Villaceque, A Sharareh, J C Dib, J Scwartz, O Hoffmann, L Ouazana, S Assouline, E Parrens, T Garban, V Pradeau, D Guedj-Meynier, B Lequeux, C Cohen, P Durand, F Dievart, T S Dhanjal, P Sabouret, N Lellouche
BACKGROUND AND AIMS: Since the introduction of direct oral anticoagulant (DOAC) for atrial fibrillation (AF) therapy, inappropriate and/or underdosing of these drugs has been a major clinical challenge. We evaluated the characteristics of AF patients treated with inappropriate and low dose DOACs. METHODS: AF patients treated with inappropriate and low dose DOACs from October 2021 to December 2021 were evaluated from the Prospective French National Registry (PAF)...
October 6, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://read.qxmd.com/read/37592406/efficacy-of-3d-multidetector-computed-tomography-and-fluoroscopy-fusion-for-percutaneous-left-atrial-appendage-occlusion-procedures
#9
JOURNAL ARTICLE
Herman A Carneiro, Luis A P Dallan, Sung-Han Yoon, Shilpkumar Arora, Juliana Knezevich, Sojin Wass, Tabitha Lobo, Mauricio Arruda, Imran Rashid, Steven J Filby
INTRODUCTION: We studied the impact of the use of three-dimensional multidetector computed tomography (3D-MDCT) and fluoroscopy fusion on percutaneous left atrial appendage occlusion (LAAO) procedures in relation to procedure time, contrast volume, fluoroscopy time, and total radiation. METHODS: This was a single-center, prospective, single-blinded, randomized control trial. Patients meeting criteria for LAAO were randomized to undergo LAAO with the WATCHMAN FLXTM device with and without 3D-MDCT-fluoroscopy fusion guidance using a prespecified protocol using computed tomography angiography for WATCHMAN FLXTM sizing, moderate sedation, and intracardiac echocardiography for procedural guidance...
August 17, 2023: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/37399699/warfarin-vs-doac-comparative-outcomes-of-mechanical-thrombectomy-for-acute-ischemic-stroke-in-atrial-fibrillation-patients
#10
JOURNAL ARTICLE
Leyla Ramazanoglu, Isil Kalyoncu Aslan, Ahmet Akpinar, Yilmaz Onal, Murat Velioglu, Eren Gozke
PURPOSE: To compare outcomes of mechanical thrombectomy (MT) for acute ischemic stroke (AIS) in patients with atrial fibrillation (AF) taking warfarin or direct oral anticoagulants (DOACs). METHODS: A total of 71 consecutive patients with AF who underwent MT due to AIS between January 2018 and December 2021 were retrospectively analyzed. Patients were grouped as warfarin versus DOAC group. CHA2 DS2 -VASc, HAS-BLED, The National Institutes of Health Stroke Scale (NIHSS) at the time of admission and at 24 h, successful recanalization, post- MT complications and technical properties of MT were evaluated...
August 2023: Clinical Neurology and Neurosurgery
https://read.qxmd.com/read/37360008/intracardiac-echocardiography-probe-via-oesophageal-to-guide-percutaneous-left-atrial-appendage-closure-procedure-a-case-series
#11
Giulia Laterra, Claudia Artale, Giorgio Sacchetta, Marco Contarini
BACKGROUND: Left atrial appendage closure (LAAC) can be an alternative to oral anticoagulant therapy in patients with non-valvular atrial fibrillation, characterized by high risk of stroke (CHA2D2VASC ≥ two for men and CHA2D2VA2SC ≥ three for women) and high risk of bleeding (HASBLED = 3). CASE SUMMARY: We describe three case reports in which an intracardiac echocardiography probe was used via the oesophageal route as an alternative to traditional transoesophageal echocardiography (TEE) or ICE methods to guide LAAC...
June 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/37009982/left-atrial-appendage-occlusion-in-an-older-population-cohort
#12
JOURNAL ARTICLE
Michael Killian, James O'Regan, Ruth Torre, Crochan J O' Sullivan
BACKGROUND: Atrial fibrillation is the most common cardiac arrhythmia and is a major risk factor for stroke, with an incidence rate of 4-5% per year. The use of DOACs is recommended for specific patient populations however the risk of bleeding commonly precludes their use. Left atrial appendage occlusion is a relatively novel procedure recommended for such patients. We set out to analyse the initial success and safety of this procedure in a single site. RESULTS: Twenty patients were included in the study with an average age of 81 years...
April 3, 2023: Irish Journal of Medical Science
https://read.qxmd.com/read/36960556/family-physician-prescribing-practices-and-perspectives-on-shared-decision-making-regarding-the-use-of-oral-anticoagulants-for-stroke-prevention-in-patients-75%C3%A2-years-or-older-with-atrial-fibrillation
#13
JOURNAL ARTICLE
Jahaan Ali, Reza Abbasi-Dezfouly, Sheny Khera, Paul Kivi, Peter George Jaminal Tian
INTRODUCTION: Atrial Fibrillation (AF) is common in older adults, yet guideline-recommended oral anti-coagulants (OACs) for stroke prevention are underused in this population. With a growing population of older adults at risk of AF seeking primary care, the objective of the study was to determine the management practices and perspectives of family physicians on the initiation of OACs for stroke prevention in AF patients 75 years or older, including their engagement of patients in shared decision-making...
2023: Journal of Primary Care & Community Health
https://read.qxmd.com/read/36909837/-just-the-two-of-us-single-operator-interventional-left-atrial-appendage-closure-a-case-report
#14
Christoph Hammerstingl, Mohammed Ali Yahya, Alexander Völz
BACKGROUND: Different procedural strategies have been published targeting to facilitate transcatheter left atrial appendage closure (LAAc). We demonstrate feasibility of a procedural set-up allowing single-operator LAAc in a selected patient. CASE SUMMARY: A 87-year-old male with persistent Afib (CHA2 DS2 VASc, five; HASBLED, three) was referred to our hospital for LAAc. Pre-procedural planning and device sizing with three-dimensional transesophageal echocardiography (3DTEE) confirmed a non-complex anatomy of the essential anatomical structures predicting suitability for LAAc...
March 2023: European Heart Journal. Case Reports
https://read.qxmd.com/read/36769499/reduced-or-half-dose-rivaroxaban-following-left-atrial-appendage-closure-a-feasible-antithrombotic-therapy-in-patients-at-high-risk-of-bleeding
#15
JOURNAL ARTICLE
Xiao-Dong Zhou, Qin-Fen Chen, Fang Lin, Liangguo Wang, Yihe Chen, Dongjie Liang, Weijian Huang, Fangyi Xiao
The optimal antithrombotic strategy after percutaneous left atrial appendage closure (LAAC) has not yet been established. The advisability of administering low-dose direct oral anticoagulation after LAAC to patients at high risk of bleeding is uncertain. Thus, in the present study, we evaluated the safety and effectiveness of reduced-(15 mg) or half-dose rivaroxaban (10 mg) versus warfarin regarding real-world risks of thromboembolism, bleeding, and device-related thrombosis (DRT) after LAAC. Patients with non-valvular atrial fibrillation and HASBLED ≥ 3 who had undergone successful LAAC device implantation from October 2014 to April 2020 were screened and those who had received 10 mg or 15 mg rivaroxaban or warfarin therapy were enrolled...
January 20, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36598300/risk-of-bleeding-after-ground-level-falls-in-elderly-patients-with-atrial-fibrillation-and-warfarin-therapy
#16
JOURNAL ARTICLE
Branislav Bezak, Marianna Barbierik Vachalcova, Viera Kissova, Peter Michalek, Jan Stevlik, Peter Jackuliak, Milos Stevove, Tomas Uher, Allan Bohm
OBJECTIVES: The aim of this study was to investigate bleeding risk in patients treated with VKAs after ground-level falls, considering the type and severity of bleeding. METHODS: The study was designed as a retrospective cohort study and included a total of 204 elderly patients aged > 65 years treated for AF continuously with warfarin for more than 3 years. Data were obtained from hospital registries in Bratislava, Slovakia. A 5-year assessment of death/survival was performed to determine mortality...
January 4, 2023: Bratislavské Lekárske Listy
https://read.qxmd.com/read/36419499/left-atrial-function-after-standalone-totally-thoracoscopic-left-atrial-appendage-exclusion-in-atrial-fibrillation-patients-with-absolute-contraindication-to-oral-anticoagulation-therapy
#17
JOURNAL ARTICLE
Massimiliano Marini, Luigi Pannone, Stefano Branzoli, Francesca Tedoldi, Giovanni D'Onghia, Diego Fanti, Emanuele Sarao, Fabrizio Guarracini, Silvia Quintarelli, Cinzia Monaco, Angelo Graffigna, Roberto Bonmassari, Mark La Meir, Gian Battista Chierchia, Carlo de Asmundis
BACKGROUND: Left atrial appendage (LAA) is a common source of thrombi in patients with atrial fibrillation (AF). The effect on left atrial (LA) function of the Totally Thoracoscopic (TT)-LAA exclusion with epicardial clip is currently unknown. This study aims at evaluating the effect of TT-LAA exclusion on LA function. METHODS: Standalone TT-LAA exclusion with the clip device was performed in 26 patients with AF and contraindication to oral anticoagulation (OAC)...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/36417811/anticoagulation-therapy-and-outcomes-in-patients-with-atrial-fibrillation-and-serious-mental-illness-a-systematic-review-and-meta-analysis
#18
REVIEW
Dina Farran, Olwyn Feely, Mark Ashworth, Fiona Gaughran
OBJECTIVE: A systematic review was conducted to investigate prevalence, management and outcomes of atrial fibrillation (AF) in people with Serious Mental Illnesses (SMI) versus the general population. DATA SOURCES: MEDLINE, EMBASE, and PsycINFO were searched for primary research written in English and published between 2004 and 2022. STUDY SELECTION: A total of 1459 studies were identified in the initial search of which 16 met the inclusion criteria...
November 16, 2022: Journal of Psychiatric Research
https://read.qxmd.com/read/36373458/therapeutic-audit-of-patients-on-warfarin-in-an-anticoagulation-clinic-of-a-tertiary-care-hospital
#19
K Sridharan, R Al Banna, A Husain
Background: Studies have reported huge variations in the prescribing practice of warfarin. We carried out a clinical audit of warfarin use in an anticoagulation clinic of a tertiary care hospital. Methods: Patients receiving warfarin for at least 6 months were recruited and the following details were collected: demographics (age, body weight and gender); diagnoses; concomitant drugs. We calcula-ted CHA₂DS₂-VASc, HASBLED and SAMe-TT2R2 scores for each study participant...
November 2022: La Clinica Terapeutica
https://read.qxmd.com/read/36362719/heart-team-for-left-appendage-occlusion-without-the-use-of-antithrombotic-therapy-the-epicardial-perspective
#20
JOURNAL ARTICLE
Stefano Branzoli, Fabrizio Guarracini, Massimiliano Marini, Giovanni D'Onghia, Domenico Catanzariti, Elettra Merola, Luciano Annicchiarico, Giulia Casagranda, Chiara Stegagno, Mauro Fantinel, Mark La Meir
BACKGROUND: Left atrial appendage occlusion is an increasingly proposed treatment for patients with atrial fibrillation and poor tolerance to anticoagulants. All endovascular devices require antithrombotic therapy. Anatomical and clinical variables predisposing to device-related thrombosis, as well as post-procedural peri-device leaks, could mandate the continuation or reintroduction of aggressive antithrombotic treatment. Because of the absence of foreign material inside the heart, epicardial appendage closure possibly does not necessitate antithrombotic therapy, but data of large series are missing...
November 1, 2022: Journal of Clinical Medicine
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