keyword
https://read.qxmd.com/read/38532027/diagnostic-imaging-of-the-diabetic-foot-an-eanm-evidence-based-guidance
#1
JOURNAL ARTICLE
Chiara Lauri, Edel Noriega-Álvarez, Riddhika M Chakravartty, Olivier Gheysens, Andor W J M Glaudemans, Riemer H J A Slart, Thomas C Kwee, Frédéric Lecouvet, Emmanouil Panagiotidis, Jules Zhang-Yin, Jose Luis Lazaro Martinez, Benjamin A Lipsky, Luigi Uccioli, Alberto Signore
PURPOSE: Consensus on the choice of the most accurate imaging strategy in diabetic foot infective and non-infective complications is still lacking. This document provides evidence-based recommendations, aiming at defining which imaging modality should be preferred in different clinical settings. METHODS: This working group includes 8 nuclear medicine physicians appointed by the European Association of Nuclear Medicine (EANM), 3 radiologists and 3 clinicians (one diabetologist, one podiatrist and one infectious diseases specialist) selected for their expertise in diabetic foot...
March 27, 2024: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38524868/the-potential-of-sheep-in-preclinical-models-for-bone-infection-research-a-systematic-review
#2
REVIEW
Michael L C Beagan, Chris H Dreyer, Louise K Jensen, Henrik E Jensen, Thomas E Andersen, Soeren Overgaard, Ming Ding
BACKGROUND: Reliable animal models are critical for preclinical research and should closely mimic the disease. With respect to route of infection, pathogenic agent, disease progression, clinical signs, and histopathological changes. Sheep have similar bone micro- and macrostructure as well as comparable biomechanical characteristics to humans. Their use in bone research is established, however their use in bone infection research is limited. This systematic review will summarise the key features of the available bone infection models using sheep, providing a reference for further development, validation, and application...
March 2024: Journal of Orthopaedic Translation
https://read.qxmd.com/read/38524028/a-rare-case-of-fungal-osteomyelitis-of-the-distal-tibia-in-a-pediatric-patient
#3
Syed Faisal Afaque, Udit Agrawal, Dilip K Shankhwar, Suresh Chand, Vikas Verma
Staphylococcus aureus infection is the most common cause of osteomyelitis. Over 100,000 fungal species have been described; only 150 are pathogenic to humans. These opportunistic infections frequently enter the body due to a decrease in host defense or through an invasive gateway, such as a dental extraction or skin discontinuity due to trauma. Symptoms and radiological examination often mimic those of other etiologies, which can lead to substantial delays in treatment. Our case is a 13-year-old healthy boy with no history of immune incompetency who presented to us with complaints of pain and swelling over his left ankle and leg with an on-and-off history of fever for 15 days...
February 2024: Curēus
https://read.qxmd.com/read/38476609/metastatic-gallbladder-cancer-presenting-as-numb-chin-syndrome-a-case-report-and-literature-review
#4
Makoto Murahashi, Edward Hosea Ntege, Kentaro Ide, Nobuyuki Maruyama, Jumpei Shirakawa, Hiroki Koyama, Toshihiro Kawano, Takahiro Goto, Yusuke Shimizu, Kazuhide Nishihara, Hiroyuki Nakamura
Gallbladder cancer (GBC) is an uncommon malignancy that is highly aggressive in the advanced stages. However, it rarely metastasizes to the mandible. Numb chin syndrome (NCS) is a rare neurological manifestation associated with various underlying causes, including occult primary cancers and distant metastases. It is often considered to be a significant indicator of malignancy, and thorough investigation is essential in the presence of unclear etiology. The current study reported on the case of a 69-year-old Japanese woman who presented with numbness and mild pain in the lower lip and chin area for three months...
April 2024: Biomedical Reports
https://read.qxmd.com/read/38449518/antibiotic-susceptibility-patterns-at-the-m%C3%A3-decins-sans-fronti%C3%A3-res-msf-acute-trauma-hospital-in-aden-yemen-a-retrospective-study-from-january-2018-to-june-2021
#5
JOURNAL ARTICLE
Hussein Almehdar, Nagwan Yousef, Wilma van den Boogaard, Amna Haider, Rupa Kanapathipillai, Emad Al-Hodiani, Evgenia Zelikova, Waddah G Moh'd, Justine Michel, Rami Malaeb
BACKGROUND: Antimicrobial resistance (AMR) is an urgent global health concern, especially in countries facing instability or conflicts, with compromised healthcare systems. Médecins Sans Frontières (MSF) established an acute trauma hospital in Aden, Yemen, treating mainly war-wounded civilians, and implemented an antimicrobial stewardship (AMS) programme. This study aimed to describe clinical characteristics and identify antibiotic susceptibility patterns representative of patients treated with antibiotics...
April 2024: JAC-antimicrobial resistance
https://read.qxmd.com/read/38373574/bacteriophage-therapy-and-current-delivery-strategies-for-orthopedic-infections-a-scoping-review
#6
REVIEW
Jason Young, Sang W Lee, Mohammad J Shariyate, Alexandria Cronin, John J Wixted, Ara Nazarian, Christopher F Rowley, Edward K Rodriguez
OBJECTIVES: Interest in phages as adjunctive therapy to treat difficult infections has grown in the last decade. However, phage dosing and delivery for orthopedic infections have not been systematically summarized. METHODS: Following PRISMA-ScR guidelines, we conducted a SCOPING review through September 1st, 2023, of MEDLINE, Embase, Web of Science Core Collection, and Cochrane Central. RESULTS: In total, 77 studies were included, of which 19 (24...
March 2024: Journal of Infection
https://read.qxmd.com/read/38330698/chronic-humeral-osteomyelitis-in-an-adult-with-sickle-cell-disease
#7
Pablo Viñuales, Paola Andrea Hortua, Jordi Zafra, Ramón Clos, Jordi Villalba
INTRODUCTION AND IMPORTANCE: The rising incidence of sickle-cell disease in European countries has led to an increase in associated complications. Osteomyelitis, a rare complication in non-traumatic adult cases, poses diagnostic challenges and presents treatment difficulties due to limited cases and studies. CASE PRESENTATION: A 23-year-old woman diagnosed with sickle-cell disease presented with a six-day fever and painful swelling in the left upper extremity persisting for a fortnight...
January 26, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38327757/oral-toxicities-associated-with-immune-checkpoint-inhibitors-meta-analyses-of-clinical-trials
#8
REVIEW
Akanksha Srivastava, Graciela M Nogueras-Gonzalez, Yimin Geng, Jasdev Singh, Jeffrey N Myers, Yisheng Li, Mark S Chambers
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment; however, their oral toxicity profile is not well elucidated. This review aimed to investigate the prevalence of oral toxicities including xerostomia, mucositis/stomatitis, dysgeusia, dysphagia, oral/oropharyngeal pain, oral infections, angular cheilitis, osteonecrosis, osteomyelitis, and oral mucosal reactions with ICIs. A review protocol was registered with PROSPERO (ID: CRD42023391674). A systematic search of ClinicalTrials.gov was conducted as of April 10, 2022...
February 2024: Journal of immunotherapy and precision oncology
https://read.qxmd.com/read/38306507/one-stage-reconstruction-of-extensive-exposed-tibia-on-malnourished-patient-using-single-layer-integra-and-amino-acid-supplements-a-case-report-and-literature-review
#9
JOURNAL ARTICLE
Kuan-I Lee, Yun-Nan Lin
RATIONALE: Extremity injuries resulting from motor vehicle collisions, especially those leading to bone-exposed wounds, present challenges for achieving effective wound coverage. Such injuries are susceptible to complications including infections, osteomyelitis, and unexpected amputations due to inadequate blood supply. Severe traumatic degloving injuries often entail damage to the surrounding blood vessels, making local or free flaps impractical choices in many cases. Consequently, treatment options may vary based on distinct clinical scenarios, with no standardized guidelines available...
February 2, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38259717/chronic-multifocal-tubercular-osteomyelitis-in-a-young-nepalese-boy-a-rare-case-presentation
#10
Shailendra Katwal, Aastha Ghimire, Rhea Bohra
This study presents a rare case of chronic multifocal tubercular osteomyelitis in a 13-year-old boy from Nepal, a high-burden country for tuberculosis (TB). He presented with chronic pain in the lower extremities and had no pre-existing comorbidities. The patient's clinical presentation, diagnostic process, and treatment plan are described. Multifocal skeletal TB, though infrequent, poses diagnostic challenges due to its variable manifestations. This case emphasizes the importance of considering TB in differential diagnoses, especially in endemic regions, necessitating a high index of suspicion...
March 2024: Radiology Case Reports
https://read.qxmd.com/read/38256225/bioactive-glass-based-materials-with-possible-application-in-diabetic-wound-healing-a-systematic-review
#11
REVIEW
Marian Vargas Guerrero, Floor M A Aendekerk, Candice de Boer, Jan Geurts, Jimmy Lucchesi, Jacobus J C Arts
Diabetes affected 537 million adults in 2021, costing a total of USD 966 billion dollars in healthcare. One of the most common complications associated with diabetes corresponds to the development of diabetic foot ulcers (DFUs). DFUs affect around 15% of diabetic patients; these ulcers have impaired healing due to neuropathy, arterial disease, infection, and aberrant extracellular matrix (ECM) degradation, among other factors. The bioactive-glass-based materials discussed in this systematic review show promising results in accelerating diabetic wound healing...
January 17, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38241664/acute-hematogenous-osteomyelitis-of-the-pelvis-in-children
#12
JOURNAL ARTICLE
Adriana Sarmiento Clemente, J Chase McNeil, Kristina G Hultén, Jesus G Vallejo, Sheldon L Kaplan
BACKGROUND: Pelvic involvement has been reported in 3%-14% of acute hematogenous osteomyelitis (AHO) cases in children. One guideline suggests need for a longer antibiotic course in pelvic AHO, however, recent data are lacking. We describe the clinical course of children with pelvic AHO and compare it to nonpelvic AHO. METHODS: A retrospective review of patients with a diagnosis of AHO admitted to Texas Children's Hospital from January 2012 to December 2020 was conducted...
January 15, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38197763/resuscitation-and-evaluation-with-intraosseous-access-a-review-of-the-literature-in-trauma-and-non-trauma-patients
#13
REVIEW
Taylor Chiang, Amanda L Teichman
According to trauma resuscitation guidelines, intraosseous (IO) access is appropriate when failure to gain intravenous (IV) access is present in trauma, burn, shock, or resuscitation settings for adults or when two failed attempts have been made in the resuscitation of a pediatric patient. However, their effectiveness and use have been debated due to concerns on flow rates, extravasation, compartment syndrome, and osteomyelitis. The objective of this review is to examine the current literature regarding intraosseous access in trauma resuscitation, focusing on interventions and complication rates...
January 10, 2024: American Surgeon
https://read.qxmd.com/read/38166791/the-importance-of-the-bacterial-spectrum-in-the-clinical-diagnostics-and-management-of-patients-with-spontaneous-pyogenic-spondylodiscitis-and-isolated-spinal-epidural-empyema-a-20-year-cohort-study-at-a-single-spine-center
#14
JOURNAL ARTICLE
Mido Max Hijazi, Timo Siepmann, Ibrahim El-Battrawy, Percy Schröttner, Dino Podlesek, Gabriele Schackert, Tareq A Juratli, Ilker Y Eyüpoglu, Andreas Filis
BACKGROUND: Personalized clinical management of spondylodiscitis (SD) and isolated spinal epidural empyema (ISEE) is challenging due to limited evidence of microbiologic findings and their clinical impact during the clinical course of the disease. We aimed to characterize clinico-microbiological and imaging phenotypes of SD and ISEE to provide useful insights that could improve outcomes and potentially modify guidelines. METHODS: We performed chart review and collected data on the following parameters: bacterial antibiogram-resistogram, type of primary spinal infection, location of spinal infection, source of infection, method of detection, clinical complications (sepsis, septic embolism, and endocarditis), length of hospital and intensive care unit (ICU) stay, relapse rate, and disease-related mortality in patients with proven pyogenic SD and ISEE treated surgically in a university hospital in Germany between 2002 and 2022...
January 2, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38153475/vertebral-candidiasis-the-state-of-the-art-a-systematic-literature-review
#15
JOURNAL ARTICLE
Dario Candura, Andrea Perna, Sara Calori, Francesco Ciro Tamburrelli, Luca Proietti, Maria Concetta Meluzio, Calogero Velluto, Amarildo Smakaj, Domenico Alessandro Santagada
OBJECTIVE: In recent years, Candida spondylodiscitis has represented an increasingly emerging disease in clinical practice. This condition requires long-term antibiotic therapy and sometimes surgical treatments. The main purpose of this study is to investigate the epidemiology, clinical and radiological aspects, treatment protocols, and outcomes of Candida-mediated vertebral osteomyelitis. METHODS: A systematic review of the English literature was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
2023: Acta Neurochirurgica. Supplement
https://read.qxmd.com/read/38079252/antibiotic-prophylaxis-for-grade-3-open-fractures-a-retrospective-comparison-of-ceftriaxone-plus-vancomycin-versus-cefazolin-plus-gentamicin
#16
JOURNAL ARTICLE
Carlee R Shifko, Daniel Jenniches, Kyle Holmberg, Derek Andreini, Allan Philp, Daniel T Altman, Derek Bremmer
Background: Because of the established path of bacterial entry and contamination-associated mechanisms, grade 3 open orthopedic fractures represent a substantial infection risk. The Eastern Association for the Surgery of Trauma (EAST) guidelines recommended covering Staphylococcus aureus and adding aminoglycoside gram-negative coverage. Local institutional guidelines rely on ceftriaxone for gram negative coverage and add methicillin-resistant Staphylococcus aureus coverage with vancomycin. Patients and Methods: The electronic health records of adults admitted for a grade 3 open fracture between January 1, 2016, and October 31, 2021, were retrospectively reviewed...
December 11, 2023: Surgical Infections
https://read.qxmd.com/read/38078940/antibiotic-prophylaxis-following-low-velocity-gunshot-fractures-an-updated-review
#17
REVIEW
Mohammad Khak, Mohammad Javad Shariyate, Juan Bernardo Villarreal-Espinosa, Nadim Kheir, Kaveh Momenzadeh, Megan McNichol, Paul Appleton, John J Wixted, Edward K Rodriguez, Ara Nazarian
PURPOSE: Low-velocity gunshot fractures (LVGFs) are a common type of gunshot-induced trauma with the potential for complications such as infection and osteomyelitis. The effectiveness of antibiotic therapy in LVGFs remains uncertain, leading to ongoing debate about the appropriate treatment. In this review, we evaluate recent updates on the current understanding of antibiotic therapy in LVGFs, how previous studies have investigated the use of antibiotics in LVGFs, and the current state of institutional policies and protocols for treating LVGFs with antibiotics...
January 2024: International Orthopaedics
https://read.qxmd.com/read/37952582/clinical-practice-recommendations-for-infectious-disease-management-of-diabetic-foot-infection-dfi-2023-spilf
#18
E Bonnet, L Maulin, E Senneville, B Castan, C Fourcade, P Loubet, D Poitrenaud, S Schuldiner, A Sotto, J P Lavigne, P Lesprit
In march 2020, the International Working Group on the Diabetic Foot (IWGDF) published an update of the 2015 guidelines on the diagnosis and management of diabetic foot infection (DFI). While we (the French ID society, SPILF) endorsed some of these recommendations, we wanted to update our own 2006 guidelines and specifically provide informative elements on modalities of microbiological diagnosis and antibiotic treatment (especially first- and second-line regiments, oral switch and duration). The recommendations put forward in the present guidelines are addressed to healthcare professionals managing patients with DFI and more specifically focused on infectious disease management of this type of infection, which clearly needs a multidisciplinary approach...
November 10, 2023: Infectious diseases now
https://read.qxmd.com/read/37952476/intraoperative-tissue-sampling-for-histology-in-chronic-osteomyelitis-shows-high-neutrophil-infiltration-centrally-and-low-remains-in-debrided-presumed-infection-free-regions
#19
JOURNAL ARTICLE
Louise Kruse Jensen, Henrik Elvang Jensen, Hans Gottlieb
INTRODUCTION: Histology of debrided bone tissue is a confirmatory diagnostic criterion for fracture related infection (FRI) and prosthetic joint infection (PJI). The aim of the present study was to describe the histopathology of the first and last debrided bone tissue in chronic osteomyelitis (CO) according to the international diagnostic guidelines for FRI and PJI. METHODS: 15 patients with CO were allocated to surgical treatment using a one-stage protocol including extensive debridement...
November 2, 2023: Injury
https://read.qxmd.com/read/37950713/diagnostic-performance-of-ultrasonography-for-diabetic-foot-osteomyelitis
#20
JOURNAL ARTICLE
Mateo López-Moral, Marta García-Madrid, Raúl J Molines-Barroso, Yolanda García-Álvarez, Francisco Javier Alvaro Afonso, José Luis Lázaro Martínez
OBJECTIVE: This study aims to analyze the potential diagnostic capability of ultrasonography in detecting diabetic foot osteomyelitis (DFO) in patients with diabetic foot ulcers (DFUs). APPROACH: A 1-year prospective study was conducted on 47 consecutive patients with active DFUs and suspicion of DFO at a specialized diabetic foot unit. The following ultrasonographic (US) features were evaluated at baseline: 1) periosteal reaction; 2) periosteal elevation; 3) cortical disruption; 4) sequestrum; and 5) positive power Doppler...
November 11, 2023: Advances in Wound Care
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