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Multidrug-resistant bacteria

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https://www.readbyqxmd.com/read/29243921/extra-sugar-on-vancomycin-new-analogues-for-combating-multidrug-resistant-staphylococcus-aureus-and-vancomycin-resistant-enterococci
#1
Dongliang Guan, Feifei Chen, Lun Xiong, Feng Tang, Faridoon Faridoon, Yunguang Qiu, Naixia Zhang, Likun Gong, Jian Li, Lefu Lan, Wei Huang
Lipophilic substitution on vancomycin is an effective strategy for development of novel vancomycin analogues against drug-resistant bacteria by enhancing bacterial cell wall interaction. However, hydrophobic structures usually led to long elimination half-life and accumulative toxicity, therefore hydrophilic fragments were also introduced to the lipo-vancomycin to regulate their PK/PD properties. Here, we synthesized a series of new vancomycin analogues carrying various sugar moieties on the 7th-amino acid phenyl ring and lipophilic substitutions on vancosamine with extensive SAR analysis...
December 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29240890/drug-development-for-multidrug-resistant-bacteria-why-compromise
#2
Mical Paul, Leonard Leibovici
No abstract text is available yet for this article.
December 12, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29238856/anti-endotoxin-mechanism-of-the-kw4-peptide-in-inflammation-in-raw-264-7-cells-induced-by-lta-and-drug-resistant-staphylococcus-aureus-1630
#3
Jong-Kook Lee, Yoonkyung Park
Drug-resistant microorganism infections cause serious disease and can lead to mortality and morbidity. In particular, Staphylococcus aureus induces pyrogenic and toxigenic infections, and drug-resistance occurs rapidly. Multidrug-resistant S. aureus, such as methicillin-resistant S. aureus and methicillin-sensitive S. aureus, can also cause immunodeficiency and immune deficiency syndrome from lipoteichoic acid. However, antimicrobial peptides, such as KW4, have strong antimicrobial activity, low cytotoxicity, and high neutralization activity against endotoxin substances from Gram-negative bacteria...
December 13, 2017: Amino Acids
https://www.readbyqxmd.com/read/29235137/development-of-hplc-with-fluorescent-detection-using-nbd-f-for-the-quantification-of-colistin-sulfate-in-rat-plasma-and-its-pharmacokinetic-applications
#4
Sui Ouchi, Kazuaki Matsumoto, Maki Okubo, Yuta Yokoyama, Junko Kizu
Colistin sulfate, composed of a mixture of colistin A sulfate (CLA) and colistin B sulfate (CLB), is available for treating life-threatening infections caused by multidrug-resistant Gram-negative bacteria. In this study, the CLA and CLB were quantified separately. Colistin sulfate was extracted from rat plasma with a solid-phase extraction C18 cartridge and reacted with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F), and the fluorescent derivatives were subjected to reversed phase high-performance liquid chromatography analysis and used to investigate the pharmacokinetics of CLA and CLB in rat plasma...
December 12, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29235021/occurrence-of-antimicrobial-agents-drug-resistant-bacteria-and-genes-in-the-sewage-impacted-vistula-river-poland
#5
Joanna Giebułtowicz, Stefan Tyski, Renata Wolinowska, Wanda Grzybowska, Tomasz Zaręba, Agata Drobniewska, Piotr Wroczyński, Grzegorz Nałęcz-Jawecki
Antimicrobial agents (antimicrobials) are a group of therapeutic and hygienic agents that either kill microorganisms or inhibit their growth. Their occurrence in surface water may reveal harmful effects on aquatic biota and challenge microbial populations. Recently, there is a growing concern over the contamination of surface water with both antimicrobial agents and multidrug-resistant bacteria. The aim of the study was the determination of the presence of selected antimicrobials at specific locations of the Vistula River (Poland), as well as in tap water samples originating from the Warsaw region...
December 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29232586/synthesis-and-biological-evaluation-of-coumarin-derivatives-containing-imidazole-skeleton-as-potential-antibacterial-agents
#6
Yang Hu, Yufeng Shen, Xiaohu Wu, Xiao Tu, Gao-Xue Wang
Emergence of multidrug-resistant bacteria causes an urgent need for new generation of antibiotics, which may have a different mechanism of inhibition or killing action from the existing. Here, we report on the design, synthesis, and biological evaluation of thirty-nine coumarin derivatives in order to solve the antibacterial resistance by targeting at the inhibition of biosynthesis pathway of fatty acids. Their antibacterial activities against Escherichia coli, Staphylococcus aureus, Streptococcus agalactiae, and Flavobacterium cloumnare are tested and action mechanism against the key enzyme in bacterial fatty acid synthesis pathway are studied...
December 5, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29232103/game-changers-new-%C3%AE-lactamase-inhibitor-combinations-targeting-antibiotic-resistance-in-gram-negative-bacteria
#7
Karen Bush
Recent regulatory approvals for the β-lactam inhibitor combinations of ceftazidime-avibactam and meropenem-vaborbactam have provided two novel therapeutic options for the treatment of multidrug-resistant infections caused by Gram-negative bacteria. Most importantly, these combination agents have satisfied an important medical need related to antibiotic-resistant Klebsiella pneumoniae that produce serine carbapenemases, especially the Klebsiella pneumoniae carbapenemase (KPC) enzymes. Both combinations contain non-β-lactam β-lactamase inhibitors of novel chemical classes not previously developed as antibacterial agents, the diazabicyclooctanes and cyclic boronic acid derivatives...
December 12, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29228556/riemerella-anatipestifer-m949_0459-gene-is-responsible-for-the-bacterial-resistance-to-tigecycline
#8
Tao Li, Min Shan, Jing He, Xiaolan Wang, Shaohui Wang, Mingxing Tian, Jingjing Qi, Tingrong Luo, Yonghong Shi, Chan Ding, Shengqing Yu
Based on its important role in last-line therapeutics against multidrug-resistant bacteria, tigecycline has been increasingly important in treating infections. However, mounting reports on tigecycline-resistant bacterial strains isolated from different sources are of concern, and molecular mechanisms regarding tigecycline resistance are poorly understood. Riemerella anatipestifer is a Gram-negative, non-motile, non-spore-forming, rod-shaped bacterium, which causes fibrinous pericarditis, perihepatitis, and meningitis in infected ducks...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228010/nasal-carriage-of-methicillin-resistant-staphylococcus-aureus-mrsa-at-a-palliative-care-unit-a-prospective-single-service-analysis
#9
Maria Heckel, Walter Geißdörfer, Franziska A Herbst, Stephanie Stiel, Christoph Ostgathe, Christian Bogdan
BACKGROUND: The emergence of multidrug-resistant bacterial microorganisms is a particular challenge for the health care systems. Little is known about the occurrence of methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Gram-negative bacteria (MDRGNB) in patients of palliative care units (PCU). AIM: The primary aim of this study was to determine the carriage of MRSA among patients of a PCU at a German University Hospital and to assess whether the positive cases would have been detected by a risk-factor-based screening-approach...
2017: PloS One
https://www.readbyqxmd.com/read/29224313/-incidence-of-blood-stream-infections-of-1265-patients-with-hematopoietic-stem-cell-transplantation-and-analysis-of-pathogenic-bacteria
#10
Q Z Han, Y Chen, H Yang, X F Zhang, J Chen, D P Wu, S N Chen, H Y Qiu
Objective: To analyze the incidence and microbiological features of blood stream infections (BSI) of patients with hematopoietic stem cell transplantation (HSCT) and to provide laboratory data for empirical use of antibiotic for the HSCT patients with BSI. Methods: The incidence of bloodstream infection, the positive rate of blood culture, bacterial spectrum and drug resistance were analyzed in 1 265 HSCT recipients during 2013 and 2015 were retrospectively studied. Results: Of 1265 patients undergoing HSCT, 1 422 cases of suspected BSI occurred in 784 patients (61...
November 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29223450/pesticide-degrading-natural-multidrug-resistance-bacterial-flora
#11
REVIEW
Kirubakaran Rangasamy, Murugan Athiappan, Natarajan Devarajan, Gopinath Samykannu, Javid A Parray, K N Aruljothi, Nowsheen Shameem, Abdulaziz A Alqarawi, Abeer Hashem, Elsayed Fathi Abd Allah
Multidrug-resistant (MDR) bacteria are a growing threat to humans across the world. Antibiotic resistance is a global problem that has developed through continuous antibiotic use, combinatorial antibiotic use, pesticide-antibiotic cross-resistance, and horizontal gene transfer, as well as various other modes. Pesticide-antibiotic cross-resistance and the subsequent expansion of drug-resistant bacteria are critically documented in this review, the primary focus of which is to assess the impact of indiscriminate pesticide use on the development of microbial communities with parallel pesticide and multidrug resistance...
December 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29222409/immune-stealth-driven-o2-serotype-prevalence-and-potential-for-therapeutic-antibodies-against-multidrug-resistant-klebsiella-pneumoniae
#12
Meghan E Pennini, Anna De Marco, Mark Pelletier, Jessica Bonnell, Romana Cvitkovic, Martina Beltramello, Elisabetta Cameroni, Siro Bianchi, Fabrizia Zatta, Wei Zhao, Xiaodong Xiao, Maria M Camara, Antonio DiGiandomenico, Elena Semenova, Antonio Lanzavecchia, Paul Warrener, JoAnn Suzich, Qun Wang, Davide Corti, C Kendall Stover
Emerging multidrug-resistant bacteria are a challenge for modern medicine, but how these pathogens are so successful is not fully understood. Robust antibacterial vaccines have prevented and reduced resistance suggesting a pivotal role for immunity in deterring antibiotic resistance. Here, we show the increased prevalence of Klebsiella pneumoniae lipopolysaccharide O2 serotype strains in all major drug resistance groups correlating with a paucity of anti-O2 antibodies in human B cell repertoires. We identify human monoclonal antibodies to O-antigens that are highly protective in mouse models of infection, even against heavily encapsulated strains...
December 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/29219107/molecular-methods-for-detection-of-antimicrobial-resistance
#13
Muna F Anjum, Ea Zankari, Henrik Hasman
The increase in bacteria harboring antimicrobial resistance (AMR) is a global problem because there is a paucity of antibiotics available to treat multidrug-resistant bacterial infections in humans and animals. Detection of AMR present in bacteria that may pose a threat to veterinary and public health is routinely performed using standardized phenotypic methods. Molecular methods are often used in addition to phenotypic methods but are set to replace them in many laboratories due to the greater speed and accuracy they provide in detecting the underlying genetic mechanism(s) for AMR...
December 2017: Microbiology Spectrum
https://www.readbyqxmd.com/read/29219055/the-role-of-nanoparticles-in-the-inhibition-of-multidrug-resistant-bacteria-and-biofilms
#14
Manaf AlMatar, Essam A Makky, Isil Var, Fatih Koksal
BACKGROUND: Until recently, one of the main reasons for mortality has been infectious diseases, and bacteria that are drug-resistant have emerged as a result of the wide application, as well as the misuse, of antibacterial medications. Having multidrug-resistance, bacteria present a great problem for the efficient management of bacterial infections and this challenge has resulted in the creation of other means of dealing with bacterial diseases. Of late, metallic nanoparticles (NPs), employed as antibacterial agents, have the potential for use against resistance to bacterial drugs...
December 7, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29217187/epidemiologic-surveillance-of-multidrug-resistant-bacteria-in-a-teaching-hospital-a-3-year-experience
#15
Mirian Nicéa Zarpellon, Giselle Fukita Viana, Cecília Saori Mitsugui, Bruno Buranello Costa, Nathalie Kira Tamura, Elisabeth Eyko Aoki, Cesar Helbel, Sheila Alexandra Belini Nishiyama, Silvia Maria Dos Santos Saalfeld, Maria Cristina Bronharo Tognim
BACKGROUND: The objective of this prospective study was to verify the effectiveness of a multidisciplinary surveillance program that was implemented in a teaching hospital in southern Brazil, to prevent and control the spread of multidrug-resistant organisms. METHODS: The program implemented involved establishment of prevention guidelines, hand-hygiene promotion, isolation of patients colonized or infected by such organisms, enforced contact precautions, and terminal cleaning and disinfection of isolation rooms...
December 4, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29216824/use-of-a-mixed-culture-strategy-to-isolate-halophilic-bacteria-with-antibacterial-and-cytotoxic-activity-from-the-manaure-solar-saltern-in-colombia
#16
Natalia Conde-Martínez, Alejandro Acosta-González, Luis E Díaz, Edisson Tello
BACKGROUND: Water evaporation in solar salterns creates salinity gradients that promote the adaptation of microbial species to different salinities. This competitive habitat challenges the metabolic capabilities of microorganisms and promotes alterations in their production of secondary metabolites. Thus, solar salterns are a potentially important source of new natural products. In Colombia, the most important and representative solar saltern is located in Manaure (La Guajira) in the north of Colombia...
December 8, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/29215863/near-infrared-laser-excited-nanoparticles-to-eradicate-multidrug-resistant-bacteria-and-promote-wound-healing
#17
Yue Qiao, Fei Ma, Chao Liu, Bo Zhou, Qiaolin Wei, Wanlin Li, Danni Zhong, Yangyang Li, Min Zhou
With the ever-growing threat of bacterial infections, especially for multidrug-resistant microbial infections, the development of highly effective treatment modalities to inhibit the infections is challenging. Although silver nanoparticles have been intensively applied as an antimicrobial agent for decades, the therapeutic efficacy towards multidrug-resistant bacteria is still unsatisfactory. Here, we show that near-infrared (NIR) laser-excited silver triangular nanoparticles (Tri-Ag) can efficiently kill Gram-negative Escherichia coli (E...
December 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29215320/early-effects-of-rhodomyrtone-on-membrane-integrity-in-methicillin-resistant-staphylococcus-aureus
#18
Wipawadee Sianglum, Dennapa Saeloh, Pongsri Tongtawe, Natthakul Wootipoom, Nitaya Indrawattana, Supayang Piyawan Voravuthikunchai
Strong evidence of high potency of rhodomyrtone as a promising antibacterial agent against pathogenic gram-positive bacteria has been clearly demonstrated in our previous work. The aim of this study was to provide insight into early action of rhodomyrtone, an acylphloroglucinol, on membrane damage in multidrug-resistant methicillin-resistant Staphylococcus aureus (MRSA). Early effects of rhodomyrtone on the bacterial membrane integrity were detected in a time-course study. Flow cytometry revealed a reduction in green fluorescent emission and increase in uptake of propidium iodide in rhodomyrtone-treated bacterial cells in a concentration- and time-dependent manner...
December 7, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29214175/what-healthcare-workers-should-know-about-environmental-bacterial-contamination-in-the-intensive-care-unit
#19
REVIEW
Vincenzo Russotto, Andrea Cortegiani, Teresa Fasciana, Pasquale Iozzo, Santi Maurizio Raineri, Cesare Gregoretti, Anna Giammanco, Antonino Giarratano
Intensive care unit- (ICU-) acquired infections are a major health problem worldwide. Inanimate surfaces and equipment contamination may play a role in cross-transmission of pathogens and subsequent patient colonization or infection. Bacteria contaminate inanimate surfaces and equipment of the patient zone and healthcare area, generating a reservoir of potential pathogens, including multidrug resistant species. Traditional terminal cleaning methods have limitations. Indeed patients who receive a bed from prior patient carrying bacteria are exposed to an increased risk (odds ratio 2...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29209304/revisiting-antibiotic-resistance-spreading-in-wastewater-treatment-plants-bacteriophages-as-a-much-neglected-potential-transmission-vehicle
#20
REVIEW
Rolf Lood, Gizem Ertürk, Bo Mattiasson
The spread of antibiotic resistance is currently a major threat to health that humanity is facing today. Novel multidrug and pandrug resistant bacteria are reported on a yearly basis, while the development of novel antibiotics is lacking. Focus to limit the spread of antibiotic resistance by reducing the usage of antibiotics in health care, veterinary applications, and meat production, have been implemented, limiting the exposure of pathogens to antibiotics, thus lowering the selection of resistant strains...
2017: Frontiers in Microbiology
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