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Multidrug-resistant bacteria

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https://www.readbyqxmd.com/read/29677485/octapeptins-lipopeptide-antibiotics-against-multidrug-resistant-superbugs
#1
Antoine Abou Fayad, Jennifer Herrmann, Rolf Müller
Antimicrobial resistance is increasing at an alarming rate. Polymyxin, one of the few antibiotics of last resort, is heavily affected. In this issue of Cell Chemical Biology, Velkov et al. (2018) present a promising alternative: octapeptin lipopeptide antibiotics active against multidrug- and extensively drug-resistant Gram-negative bacteria, which might help overcoming resistance toward polymyxins.
April 19, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29672023/chitosan-based-peptidopolysaccharides-as-cationic-antimicrobial-agents-and-antibacterial-coatings
#2
Dicky Pranantyo, Li Qun Xu, En-Tang Kang, Mary B Chan-Park
The rapid spread of multidrug resistant bacteria has called for effective antimicrobial agents which work on a more direct mechanism of killing. Cationic peptidopolysaccharides are developed in the present work to mimic the peptidoglycan structure of bacteria and to enhance the membrane-compromising bactericidal efficacy. Antimicrobial CysHHC10 peptide was grafted to the C-2 (amino) or C-6 (hydroxyl) position of chitosan backbone via thiol-maleimide 'click' conjugation, utilizing the maleimidohexanoic linkers...
April 19, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29670380/emerging-treatment-options-for-acute-bacterial-skin-and-skin-structure-infections-focus-on-intravenous-delafloxacin
#3
REVIEW
Elda Righi, Alessia Carnelutti, Antonio Vena, Matteo Bassetti
The increase in hospitalization due to acute bacterial skin and skin structure infections (ABSSSI) caused by resistant pathogens supports the need for new treatment options. Antimicrobial options for ABSSSI that provide broad-spectrum coverage, including gram-negative pathogens and multidrug-resistant gram-positive bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), are limited. Delafloxacin is a novel fluoroquinolone available as intravenous and oral formulations and is characterized by an increased efficacy in acidic environments and activity on bacterial biofilm...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29668795/antibacterial-activity-of-lamiaceae-plant-extracts-in-clinical-isolates-of-multidrug-resistant-bacteria
#4
Felipe V DE Assis, Flávia L Siqueira, Isabela E Gonçalves, Rafael P Lacerda, Rafaela A Nascimento, Sthéfane G Araújo, Jéssica T Andrade, Karina M S Herrera, Luciana A R S Lima, Jaqueline M S Ferreira
The antibacterial activity of plant extracts of the Lamiaceae family was evaluated against clinical isolates of multi-resistant Gram-negative bacteria by broth microdilution technique. Promising results were obtained considering that all extracts were active for at least two bacterial species with MIC ranging from 0.5 to 2.0 mg/mL.
April 16, 2018: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/29665661/-beter-uderstanding-of-the-diagnosis-and-treatment-of-pneumonia-in-the-era-of-multidrug-resistant-bacteria
#5
L Zhu
No abstract text is available yet for this article.
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29665289/a-whole-body-physiologically-based-pharmacokinetic-model-for-colistin-and-colistin-methanesulfonate-cms-in-rat
#6
Salim Bouchene, Sandrine Marchand, William Couet, Lena E Friberg, Patrice Gobin, Isabelle Lamarche, Nicolas Grégoire, Sven Björkman, Mats O Karlsson
Colistin is a polymyxin antibiotic used to treat patients infected with multidrug-resistant Gram negative bacteria (MDR-GNB). The objective of this work was to develop a whole-body physiologically based pharmacokinetic (WB-PBPK) model to predict tissue distribution of colistin in rat. The distribution of a drug in a tissue is commonly characterized by its tissue-to-plasma partition coefficient, Kp . Colistin and its prodrug, colistin methanesulfonate (CMS) Kp priors were measured experimentally from rat tissue homogenates or predicted in silico...
April 17, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29664197/impact-of-systemic-antimicrobial-therapy-on-mucosal-staphylococci-in-a-population-of-dogs-in-northwest-england
#7
Vanessa M Schmidt, Gina Pinchbeck, Tim Nuttall, Steve Shaw, K Marie McIntyre, Neil McEwan, Susan Dawson, Nicola J Williams
BACKGROUND: Antimicrobial-resistant bacteria are increasingly isolated from veterinary patients. OBJECTIVES: To determine risk factors for antimicrobial resistance (AMR) among canine mucosal staphylococci following routine antimicrobial treatment with cefalexin (CFX), clavulanate-amoxicillin (AC), cefovecin (CVN), clindamycin (CD) or a fluoroquinolone (FQ). ANIMALS: Mucosal swab samples (n = 463) were collected from 127 dogs pre-treatment, immediately, and at one- and three-months post-treatment...
April 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29663932/studies-on-the-antibacterial-activity-and-mechanism-of-antimicrobial-peptides-against-drug-resistant-bacteria
#8
Xiaofang Luo, Yanjun Liu, Zuodong Qin, Zhiyuan Jin, Liting Xu, Yang Liu, Linyan Cao, Fulin He, Xiaohong Gu, Xiaoping Ouyang
Antibiotic resistance is a growing threat to human health. More than anything else, multidrug-resistant gram-negative bacteria pose the biggest challenge to healthcare, which is predominantly due to the lack of effective therapeutic options. In the present study, we investigated the activities of peptides HX-12A, HX-12B and HX-12C against MDRAB and MDRKP isolates in vitro. Those three peptides displayed high antibacterial activities and rapid bactericidal effects against MDRAB and MDRKP isolates. Additionally, the peptides retained their activity even being present in pH 6...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29660875/metagenomic-analysis-of-antibiotic-resistance-genes-args-during-refuse-decomposition
#9
Xi Liu, Shu Yang, Yangqing Wang, He-Ping Zhao, Liyan Song
Landfill is important reservoirs of residual antibiotics and antibiotic resistance genes (ARGs), but the mechanism of landfill application influence on antibiotic resistance remains unclear. Although refuse decomposition plays a crucial role in landfill stabilization, its impact on the antibiotic resistance has not been well characterized. To better understand the impact, we studied the dynamics of ARGs and the bacterial community composition during refuse decomposition in a bench-scale bioreactor after long term operation (265d) based on metagenomics analysis...
April 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29659796/dissemination-of-multi-resistant-gram-negative-bacteria-into-german-wastewater-and-surface-waters
#10
Heike Müller, Esther Sib, Mike Gajdiss, Ursula Klanke, Franziska Lenz-Plet, Vanessa Barabasch, Cathrin Albert, Anna Schallenberg, Christian Timm, Nicole Zacharias, Ricarda Maria Schmithausen, Steffen Engelhart, Martin Exner, Marijo Parcina, Christiane Schreiber, Gabriele Bierbaum
Carbapenem antibiotics constitute the mainstay therapy of nosocomial infections with ESBL (extended spectrum beta-lactamase) producing Gram-negative bacteria, however, resistance against these compounds is increasing. This study was designed to demonstrate that carbapenemase-producing bacteria are disseminated from hospitals into the environment. To this end, resistant bacteria were isolated from a clinical/urban and from a rural catchment system in Germany in 2016/17. The study followed the dissemination of resistant bacteria from the wastewater through the wastewater treatment plant into the receiving surface waters...
April 6, 2018: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/29659523/antibacterial-efficacy-of-silver-nanoparticles-on-endometritis-caused-by-prevotella-melaninogenica-and-arcanobacterum-pyogenes-in-dairy-cattle
#11
Sangiliyandi Gurunathan, Yun-Jung Choi, Jin-Hoi Kim
Bovine postpartum diseases remain one of the most significant and highly prevalent illnesses with negative effects on the productivity, survival, and welfare of dairy cows. Antibiotics are generally considered beneficial in the treatment of endometritis; however, frequent usage of each antibiotic drug is reason for the emergence of multidrug resistance (MDR) of the pathogenic microorganisms, representing a major impediment for the successful diagnosis and management of infectious diseases in both humans and animals...
April 16, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29658220/-multiresistant-bacteria-practical-aspects-for-doctors-working-in-ambulatory-practice
#12
Sarah Masson-Roy, Stephan Harbarth
Although preventive measures against the transmission of multidrug-resistant organisms (MDROs) are well established and protocolized in hospital settings, their implementation in private ambulatory practice are rarely addressed. Despite what is sometimes communicated, the risk of transmission of this type of bacteria outside of a hospital environment is real. Standard precautions are the key to minimizing this risk. In a number of situations in the ambulatory setting, MDRO screening (nasal or rectal) is needed and recommended...
April 11, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29658045/potential-of-borojoa-patinoi-cuatrecasas-water-extract-to-inhibit-nosocomial-antibiotic-resistant-bacteria-and-cancer-cell-proliferation-in-vitro
#13
Clemencia Chaves-López, Donatella Usai, Matthew Gavino Donadu, Annalisa Serio, Robert Tulio González-Mina, Maria Chiara Simeoni, Paola Molicotti, Stefania Zanetti, Antonio Pinna, Antonello Paparella
Borojó (Borojoa patinoi Cuatrec.) is a fruit used in Colombian traditional medicine with supposed antihypertensive, antitumoral, diuretic, healing, immunological, anti-inflammatory and aphrodisiac effects. To explore the relative merits in terms of biological activities of borojó aqueous extract (BAE), we investigated in vitro its antimicrobial activity on nosocomial pathogenic and multidrug resistant (MDR) strains of Pseudomonas aeruginosa (6), Staphylococcus aureus (1) and Candida species (6), as well as its cytotoxicity on human conjunctive Wong-Kilbourne derivative (WKD) cells and Caco-2 cells from heterogeneous human epithelial colorectal adenocarcinoma...
April 16, 2018: Food & Function
https://www.readbyqxmd.com/read/29657429/isolation-and-identification-of-bacteria-causing-mastitis-in-small-ruminants-and-their-susceptibility-to-antibiotics-honey-essential-oils-and-plant-extracts
#14
Abeer Mostafa Abdalhamed, Gamil Sayed Gamil Zeedan, Hala Abdoula Ahmed Abou Zeina
Aim: The present work aims to isolate and identify bacteria that cause mastitis in small ruminants and evaluates the antibacterial activity of some antibiotics, honey, essential oils, and plant extracts. Materials and Methods: A total of 289 milk samples were collected from udder secretions of sheep (n=189) and goat (n=100) from El-Fayoum, Beni-Suef, and Giza governorates. Screening subclinical mastitis (SCM) was done using California Mastitis Test (CMT); identification of the isolates was achieved using Gram's staining, hemolytic pattern, colony morphology, and biochemical tests using Analytical Profile Index...
March 2018: Veterinary World
https://www.readbyqxmd.com/read/29657216/colistin-induced-myasthenic-syndrome-in-a-patient-with-end-stage-renal-disease
#15
Pratim Sengupta, Sumanta Biswas
With resurgence of multidrug resistance (MDR) bacteria and no new novel broad-spectrum antibiotic in research pipeline, usage of older generation antibiotics, once discarded due to their toxicity profile are becoming popular again. Often these drugs are the only option left in managing MDR bacteria-related sepsis. Colistin is one of such antibiotic which is often used in recent times after decades of its avoidance due to its diverse toxicity profile. In this case report, we present a rare myasthenic syndrome like neuromuscular complication developed in a patient after receiving colistin for treatment of MDR Klebsiella-related urosepsis...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29652864/honey-bee-as-alternative-medicine-to-treat-eleven-multidrug-resistant-bacteria-causing-urinary-tract-infection-during-pregnancy
#16
Mabrouka Bouacha, Hayette Ayed, Nedjoud Grara
Medicinal benefits of honey bee have been recognized in the medical community since ancient times as a remedy for many diseases and infections. This study aimed to investigate the in vitro susceptibility of 11 multidrug-resistant bacterial strains, isolated from urinary tract infections of pregnant women, to six honey samples collected from different localities in the east of Algeria. The evaluation of the antibacterial activity was performed by the well method followed by the broth dilution method using two-fold dilutions of each honey sample ranging from 2...
April 13, 2018: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/29652690/endophthalmitis-after-pars-plana-vitrectomy-efficacy-of-intraoperative-subconjunctival-antibiotics
#17
Stephanie J Weiss, Murtaza K Adam, Xinxiao Gao, Anthony Obeid, Arunan Sivalingam, Mitchell S Fineman, Joseph I Maguire, Sunir J Garg, Julia Haller, David H Fischer, Jason Hsu
PURPOSE: To examine rates of acute infectious endophthalmitis after pars plana vitrectomy (PPV) in eyes that received intraoperative subconjunctival antibiotics versus eyes that did not. METHODS: A retrospective, nonrandomized, comparative case series of 18,886 consecutive cases of transconjunctival 23-, 25-, and 27-gauge PPV over a 5-year period was performed. The impact of prophylactic intraoperative subconjunctival antibiotics on the development of acute infectious postoperative endophthalmitis was examined...
April 12, 2018: Retina
https://www.readbyqxmd.com/read/29649549/bloodstream-infections-in-cancer-patients-risk-factors-associated-with-mortality
#18
Beda Islas-Muñoz, Patricia Volkow-Fernández, Cynthia Ibanes-Gutiérrez, Alberto Villamar-Ramírez, Diana Vilar-Compte, Patricia Cornejo-Juárez
OBJECTIVE: The aim of this study was to evaluate the clinical characteristics and risk factors associated with mortality in cancer patients with bloodstream infections (BSI), analyzing multidrug resistant bacteria (MDRB). METHODS: We conducted a prospective observational study at a cancer referral center from August 2016 to July 2017, which included all BSI. RESULTS: 4,220 patients were tested with blood cultures; 496 were included. Mean age was 48 years...
April 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29649276/carbapenem-resistant-gram-negative-pathogens-in-a-german-university-medical-center-prevalence-clinical-implications-and-the-role-of-novel-%C3%AE-lactam-%C3%AE-lactamase-inhibitor-combinations
#19
Juri Katchanov, Lucia Asar, Eva-Maria Klupp, Anna Both, Camilla Rothe, Christina König, Holger Rohde, Stefan Kluge, Florian P Maurer
OBJECTIVES: To determine the spectrum of infections with multidrug-resistant Gram-negative bacteria (MDR-GNB) and the clinical impact of the newly available betalactam/betalactamase inhibitor combinations ceftolozane/tazobactam and ceftazidime/avibactam in a German academic tertiary care center. METHODS: Retrospective analysis. RESULTS: Between September 1, 2015 and August 31, 2016, 119 individual patients (0.22% of all hospital admissions) were colonized or infected with carbapenem-resistant MDR-GNB...
2018: PloS One
https://www.readbyqxmd.com/read/29627985/strategic-approaches-to-overcome-resistance-against-gram-negative-pathogens-using-%C3%AE-lactamase-inhibitors-and-%C3%AE-lactam-enhancers-the-activity-of-three-novel-diazabicyclooctanes-wck-5153-zidebactam-wck-5107-and-wck-4234
#20
Krisztina M Papp-Wallace, Nhu Q Nguyen, Michael R Jacobs, Christopher R Bethel, Melissa D Barnes, Vijay Kumar, Saralee Bajaksouzian, Susan D Rudin, Philip N Rather, Satish Bhavsar, Tadiparthi Ravikumar, Prasad K Deshpande, Vijay Patil, Ravindra Yeole, Sachin S Bhagwat, Mahesh V Patel, Focco van den Akker, Robert A Bonomo
Limited treatment options exist to combat infections caused by multidrug-resistant (MDR) Gram negative bacteria possessing broad-spectrum β-lactamases. The design of novel β-lactamase inhibitors is of paramount importance. Here, three novel diazabicyclooctanes (DBOs), WCK 5153, zidebactam (WCK 5107), and WCK 4234 (compounds 1-3) were synthesized and biochemically characterized against clinically important bacteria. Compound 3 inhibited class A, C and D β-lactamases with unprecedented k2/K values against OXA carbapenemases...
April 7, 2018: Journal of Medicinal Chemistry
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