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https://www.readbyqxmd.com/read/28742516/prevention-of-renal-ischemia-perfusion-induced-renal-and-hepatic-injury-in-adult-male-albino-rats-by-oxytocin-role-of-nitric-oxide
#1
Merhan Mamdouh Ragy, Neven Makram Aziz
BACKGROUND: Oxytocin (OT) has an anti-inflammatory and antioxidant effect in the different inflammatory models. The current study aimed to evaluate the protective function of OT in renal and hepatic damages triggered by renal ischemia/reperfusion (IR) in rats. Moreover, the effect of NG-nitro-l-arginine methyl ester (l-NAME) was investigated on the kidney and liver functions in renal IR model. METHODS: Twenty-four rats were divided into four groups (six rats each) as follows: (1) Sham-operated group; (2) Renal IR group; (3) Renal IR+OT group; (4) Renal IR+OT+l-NAME...
July 25, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28742210/clinical-research-on-correction-of-ankle-arthritis-related-factor-levels-via-urea
#2
C Sun, S Zhang, L Wei, J-Z Zhang
OBJECTIVE: To investigate the reliability of urea as the internal reference of ankle irrigating fluid in correction of synovial fluid and related factor concentration dilution times, and to further determine the factor expression level in synovial fluid. PATIENTS AND METHODS: A total of 91 patients, including 20 cases of non-posterior median foot lesions and 71 cases of unilateral ankle osteoarthritis, were enrolled in this study. AOFAS score, Takakura staging and visual analogue pain scale were given; the venous blood was collected and the ankle fluid and irrigating fluid were obtained from the affected side via puncture...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28741726/ns1643-enhances-ionic-currents-in-a-g604s-wt-herg-co-expression-system-associated-with-long-qt-syndrome-2
#3
JianHua Huo, Xueyan Guo, Qun Lu, Hua Qiang, Ping Liu, Ling Bai, Christopher L H Huang, Yanmin Zhang, Aiqun Ma
Loss of function mutations in the human ether-a-go-go-related gene (hERG) cause long QT syndrome type 2 (LQT2). Most LQT2 patients are heterozygous mutation carriers in which the mutant hERG exerts potent dominant-negative effects. 1, 3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) is known to enhance IKr in WT-hERG. We investigated its actions following lipofectamine-induced expression of both mutant G604S- and WT-hERG in the heterologous HEK293 expression system. Cells transfected with pcDNA3-G604S-hERG did not lead to any expression of detectable currents whether before or following NS1643 challenge...
July 25, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28741715/first-report-of-carglumic-acid-in-a-patient-with-citrullinemia-type-1-argininosuccinate-synthetase-deficiency
#4
E Kose, P Kuyum, B Aksoy, J Häberle, N Arslan, Y Ozturk
WHAT IS KNOWN AND OBJECTIVE: Carglumic acid is a structural analogue of human N-acetylglutamate, which has become an alternative therapeutic option for hyperammonaemia in organic acidaemias such as isovaleric acidaemia, methylmalonic acidaemia and propionic acidaemia, and it has been suggested in other urea cycle disorders such as ornithine transcarbamylase deficiency and carbamoyl phosphate synthetase 1 deficiency. CASE DESCRIPTION: A male newborn was diagnosed with citrullinemia after serum amino acid analyses revealed markedly elevated citrulline concentration together with homozygous p...
July 25, 2017: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/28741343/relationships-between-certain-metabolic-diseases-and-selected-serum-biochemical-parameters-in-seropositive-dairy-cows-against-neospora-caninum-infection-in-different-stages-of-lactation
#5
Myassar O. Alekish, Abdelsalam Q Talafha, Musa A Alshehabat, Zuhair A Bani Ismail
Neospora caninum is an important cause of abortion in dairy cattle. The general health of affected cows has not been investigated before. Therefore, the main objective of this study was to identify possible relationships between certain metabolic diseases and selected serum biochemical parameters in seropositive dairy cows against N. caninum antibodies in different stages of lactation. The study was carried out using 72 N. caninum seropositive cows and 61 seronegative dairy cows (control). Serum from all cows was tested to determine their N...
2017: Annals of Parasitology
https://www.readbyqxmd.com/read/28740939/effect-of-a-short-period-whole-body-vibration-with-10-hz-on-blood-biomarkers-in-wistar-rats
#6
Milena de Oliveira Bravo Monteiro, Danúbia da Cunha de Sá-Caputo, Eloá Moreira-Marconi, Éric Heleno Freire Ferreira Frederico, Cintia Renata de Sousa-Gonçalves, Luciana Camargo Bernardo, Carlos Alberto Sampaio Guimarães, Mario Bernardo-Filho
BACKGROUND: Exposure to whole body vibration exercises (WBVE), besides some biological effects, causes alterations in the concentration of some blood biomarkers. The aim of this study is to evaluate the action of vibration (10 Hz) of WBVE on the concentration of blood biomarkers in Wistar rats. MATERIALS AND METHODS: Wistar rats were divided in 2 groups. The experimental group (EG) was subjected to vibrations of 10Hz (one min per day, one week, total time of seven min), while the control group (CG) has not experienced vibration...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28740663/evaluation-of-platelet-lymphocyte-ratio-and-90-day-mortality-in-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#7
Praneel Kumar, Stephanie Law, Krishna B Sriram
BACKGROUND: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have high mortality and health care costs. The platelet to lymphocyte ratio (PLR) is a marker of inflammation and has been reported to be elevated in patients with AECOPD compared to stable state. In this study, we sought to evaluate the association of the PLR in patients with AECOPD with 90-day mortality. METHODS: We conducted a retrospective cohort study of patients admitted to our institution with a primary diagnosis of AECOPD between January 2014 and July 2014...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740392/cholecalciferol-improves-glycemic-control-in-type-2-diabetic-patients-a-6-month-prospective-interventional-study
#8
Aml Mohamed Nada, Dalia A Shaheen
BACKGROUND AND PURPOSE: To investigate the effects of vitamin D supplementation on glucose homeostasis and lipid profile in type 2 diabetic patients who have vitamin D deficiency. PATIENTS AND METHODS: One hundred twenty-five type 2 diabetic patients taking oral hypoglycemic agents as mono- or combination therapy were recruited from the diabetes and endocrinology clinic. Subject demographics, duration of diabetes, antidiabetic medication, body mass index (BMI), pulse, and blood pressure (BP) were assessed...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28739326/solubility-volumetric-and-compressibility-properties-of-acetaminophen-in-some-aqueous-solutions-of-choline-based-deep-eutectic-solvents-at-t-288-15-to-318-15-k
#9
Hemayat Shekaari, Mohammed Taghi Zafarani-Moattar, Masumeh Mokhtarpour
Deep eutectic solvents (DESs) as a new class of green solvents have been used to overcome the low solubility of drugs during the recent years. In this work, the effect of some DESs containing choline chloride as hydrogen bond acceptor and urea, oxalic acid and malonic acid as hydrogen bond donors have been studied on acetaminophen (ACP) solubility at temperature ranges (298.15 to 313.15) K. The results indicate that the solubility of ACP increase with increasing concentration of DES and at higher temperatures and the DES containing malonic acid have a greater impact on the solubility of acetaminophen...
July 21, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28738571/determination-of-polycyclic-aromatic-hydrocarbons-in-infant-formula-using-solid-state-urea-clathrate-formation-with-gas-chromatography-tandem-mass-spectrometry
#10
Zoltán Nyiri, Márton Novák, Zsolt Bodai, Noémi Petrovics, Zsuzsanna Eke
An analytical method has been developed for the quantitative determination of the 16 EU priority polycyclic aromatic hydrocarbons (PAHs) in infant formula. Prior to analysis infant formula is subjected to sample preparation including the extraction of PAHs from the sample, transesterification of the triglyceride content of the extract to fatty acid methyl esters (FAMEs), and solid state urea clathrate formation to remove the FAMEs. Measurements were carried out with gas chromatography - tandem mass spectrometry...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738532/genipin-attenuates-cisplatin-induced-nephrotoxicity-by-counteracting-oxidative-stress-inflammation-and-apoptosis
#11
Eglal Mahgoub, Shanmugam Muthu Kumaraswamy, Kamal Hassan Kader, Balaji Venkataraman, Shreesh Ojha, Ernest Adeghate, Mohanraj Rajesh
Cisplatin (CP) is a potent and widely used chemotherapeutic agent. However, the clinical benefits of CP are compromised because it elicits nephrotoxicity and ototoxicity. In this study, we investigated the nephroprotective effects of the phytochemical genipin (GP) isolated from the gardenia (Gardenia jasminoides) fruit, using a murine model of CP-induced nephropathy. GP pretreatment attenuated the CP-induced renal tissue injury by diminishing the serum blood urea nitrogen, creatinine, and cystatin C levels, as well as those of kidney injury molecule-1...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738306/adipocyte-fatty-acid-binding-protein-4-fabp4-inhibitors-a-comprehensive-systematic-review
#12
REVIEW
Giuseppe Floresta, Venerando Pistarà, Emanuele Amata, Maria Dichiara, Agostino Marrazzo, Orazio Prezzavento, Antonio Rescifina
Small molecule inhibitors of adipocyte fatty acid binding protein 4 (FABP4) have attracted interest following the recent publications of beneficial pharmacological effects of these compounds. FABP4 is predominantly expressed in macrophages and adipose tissue where it regulates fatty acids (FAs) storage and lipolysis and is an important mediator of inflammation. In the past years, hundreds FABP4 inhibitors have been synthesized for effective atherosclerosis and diabetes treatments, including derivatives of niacin, quinoxaline, aryl-quinoline, bicyclic pyridine, urea, aromatic compounds and other novel heterocyclic compounds...
July 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28738230/fluorinated-tripodal-receptors-for-potentiometric-chloride-detection-in-biological-fluids
#13
Nadezda Pankratova, Maria Cuartero, Laura A Jowett, Ethan N W Howe, Philip A Gale, Eric Bakker, Gastón A Crespo
Fluorinated tripodal compounds were recently reported to be efficient transmembrane transporters for a series of inorganic anions. In particular, this class of receptors has been shown to be suitable for the effective complexation of chloride, nitrate, bicarbonate and sulfate anions via hydrogen bonding. The potentiometric properties of urea and thiourea-based fluorinated tripodal receptors are explored here for the first time, in light of the need for reliable sensors for chloride monitoring in undiluted biological fluids...
July 8, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28738155/engineering-aromatic-aromatic-interactions-to-nucleate-folding-in-intrinsically-disordered-regions-of-proteins
#14
Swati Balakrishnan, Siddhartha Peddibhotla Sarma
Aromatic interactions are known to be an important force in protein folding as they combine the stability of a hydrophobic interaction with the selectivity of a hydrogen bond. Much of our understanding of aromatic interactions comes from analyses of protein structures and from the contribution of these interactions to stabilizing secondary structure motifs in model peptides. In this study the structural consequences of aromatic interactions on protein folding have been explored in engineered mutants of the molten globule protein apo - cytochrome b5...
July 24, 2017: Biochemistry
https://www.readbyqxmd.com/read/28738065/impact-of-controlled-release-urea-on-maize-yield-and-nitrogen-use-efficiency-under-different-water-conditions
#15
Guanghao Li, Bin Zhao, Shuting Dong, Jiwang Zhang, Peng Liu, Tony J Vyn
Controlled release urea (CRU) has been widely adopted to increase nitrogen (N) use efficiency and maize production, but the impacts can range widely depending on water availability in the soil. In an experiment using Zhengdan 958 (a popular summer maize hybrid), three levels of water treatments (adequate water condition [W3], which maintained soil moisture at about 75% ± 5% of the soil's field capacity; mild water stress [W2], which maintained moisture content at 55% ± 5% of field capacity; and severe water stress [W1], which had a moisture content of 35% ± 5% of field capacity) and four levels of controlled release urea fertilizer (N0, N1, N2 and N3 were 0, 105, 210 and 315 kg N ha-1, respectively) were compared in a rainout shelter system with soil...
2017: PloS One
https://www.readbyqxmd.com/read/28736810/the-effects-of-bacterial-infection-on-human-sperm-nuclear-protamine-p1-p2-ratio-and-dna-integrity
#16
A Zeyad, M F Hamad, M E Hammadeh
The purpose of this study was to detect the effects of bacterial infection on human sperm nuclear protamines and DNA fragmentation. In this study, 120 semen samples were collected from unselected male partners of couples consulting for infertility in infertility and obstetrics clinic. All the samples were screened bacteriologically according to World Health Organization guidelines, and also sperm parameters and DNA fragmentation were evaluated. The concentrations of protamines P1 and P2 were quantified using acid urea acrylamide gel electrophoresis...
July 23, 2017: Andrologia
https://www.readbyqxmd.com/read/28736007/development-and-validation-of-a-nomogram-for-predicting-incidence-of-early-allograft-dysfunction-following-liver-transplantation
#17
L Yang, E Y Xin, B Liao, L J Lai, M Han, X P Wang, W Q Ju, D P Wang, Z Y Guo, X S He
OBJECTIVE: Early allograft dysfunction (EAD) is frequent complication post-liver transplantation and is closely related to recipient's mortality and morbidity. We sought to develop a nomogram for predicting incidence of EAD. METHODS: Based on multivariate analysis of donor, recipient, and operation data of 199 liver transplants from deceased donors between 2013 and 2015, we identified 5 significant risk factors for EAD to build a nomogram. The model was subjected to prospective validation with a cohort of 42 patients who was recruited between January and June 2016...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28735377/study-of-the-correlation-between-fengycin-promoter-expression-and-its-production-by-bacillus-subtilis-under-different-culture-conditions-and-the-impact-on-surfactin-production
#18
Yazen Yaseen, Frédérique Gancel, Max Béchet, Djamel Drider, Philippe Jacques
This work aimed to rely expression of the fengycin promoter to fengycin production under different culture conditions. To this end, Bacillus subtilis BBG208, derived from BBG21, which is a fengycin overproducing strain carrying the green fluorescent protein (GFP) under the control of fengycin promoter, was used to assess the effects of different carbon and nitrogen sources on surfactin and fengycin production and the fengycin promoter expression. The data showed that some carbon sources oriented synthesis of one family of lipopeptides, while most of the nitrogen sources allowed high co-production of fengycin and surfactin...
July 22, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28735207/nutrient-balancing-for-phytoremediation-enhancement-of-urea-manufacturing-raw-wastewater
#19
Sara Yavari, Amirhossein Malakahmad, Nasiman B Sapari, Saba Yavari, Eakalak Khan
Application of urea manufacturing wastewater to teak (Tectona grandis) trees, a fast growing tropical timber plants, is an environmentally-friendly and cost-effective alternative for treatment of nitrogen-rich wastewater. However, the plant growth is strongly limited by lack of phosphorus (P) and potassium (K) elements when the plants are irrigated with wastewater containing high concentration of nitrogen (N). A greenhouse experiment was conducted to optimize the efficiency of teak-based remediation systems in terms of nutrient balance...
July 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28735170/effects-of-different-solvents-on-the-conformations-of-apoptotic-cytochrome-c-structural-insights-from-molecular-dynamics-simulation
#20
Gurusamy Muneeswaran, Subramanian Kartheeswaran, Kaliappan Muthukumar, Christopher D Dharmaraj, Chandran Karunakaran
Cytochrome c (cyt-c) upon binding with cardiolipin acquires peroxidase activity and is strictly connected to the pathogenesis of many human diseases including neurodegenerative and cardiovascular diseases. Interaction of cyt-c with cardiolipin mimics partial unfolding/conformational changes of cyt-c in different solvent environments. Dynamic pictures of these conformational changes of cyt-c are crucial in understanding their physiological roles in mitochondrial functions. Therefore, atomistic molecular dynamics (MD) simulations have been carried out to investigate the effect of different solvents (water, urea/water, MeOH and DMSO) on the structure and conformations of apoptotic cyt-c (Fe(3+))...
July 14, 2017: Journal of Molecular Graphics & Modelling
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