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https://www.readbyqxmd.com/read/29351544/long-term-exposure-to-fine-particulate-matter-blood-pressure-and-incident-hypertension-in-taiwanese-adults
#1
Zilong Zhang, Cui Guo, Alexis K H Lau, Ta-Chien Chan, Yuan Chieh Chuang, Changqing Lin, Wun Kai Jiang, Eng-Kiong Yeoh, Tony Tam, Kam S Woo, Bryan P Yan, Ly-Yun Chang, Martin C S Wong, Xiang Qian Lao
BACKGROUND: Long-term exposure to particulate matter (PM) air pollution may increase blood pressure and the risk of hypertension. However, epidemiological evidence is scarce and inconsistent. OBJECTIVES: We investigated the associations between long-term exposure to PM with an aerodynamic diameter <2.5μm (PM2.5), blood pressure, and incident hypertension in a large Taiwanese cohort. METHODS: We studied 361,560 adults ≥18y old from a large cohort who participated in a standard medical examination program during 2001 to 2014...
January 18, 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29351405/acute-down-regulation-of-mir-199a-attenuates-sepsis-induced-acute-lung-injury-by-targeting-sirt1
#2
Yang Liu, Hao Guan, Ju-Lei Zhang, Zhao Zheng, Hong-Tao Wang, Ke Tao, Shi-Chao Han, Lin-Lin Su, Dahai Hu
MiR-199a is a novel gene regulator with an important role in inflammation and lung injury. However, its role in the pathogenesis of sepsis-induced acute respiratory distress syndrome (ARDS) is currently unknown. Our study explored the role of miR-199a in sepsis-induced ARDS and its mechanism of action. First, we found that LPS could up-regulate miR-199a in alveolar macrophages. Down-regulation of miR-199a inhibited the up-regulation of inflammatory cytokines in alveolar macrophages and induced the remission of histopathologic changes, the reduction of pro-inflammatory cytokines, and the up-regulation of apoptosis protein expression in an ARDS lung, showing a protective role for miR-199a...
January 10, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29351359/cyr61-ccn1-regulates-sclerostin-levels-and-bone-maintenance
#3
Gexin Zhao, Bau-Lin Huang, Diana Rigueur, Weiguang Wang, Chimay Bhoot, Kemberly R Charles, Jongseung Baek, Subburaman Mohan, Jie Jiang, Karen M Lyons
CYR61/CCN1 is a matricellular protein that resides in the extracellular matrix, but serves regulatory rather than structural roles. CYR61/CCN1 is found in mineralized tissues and has been shown to influence bone healing in vivo and osteogenic differentiation in vitro. In this study we generated Cyr61 bone specific knockout mice to examine the physiological role of CYR61/CCN1 in bone development and maintenance in vivo. Extensive analysis of Cyr61 conditional knockout mice showed a significant decrease in both trabecular and cortical bone mass as compared to WT littermate...
January 19, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29351316/dexmedetomidine-reduces-lipopolysaccharide-induced-neuroinflammation-sickness-behavior-and-anhedonia
#4
Ching-Hua Yeh, Liang-Po Hsieh, Ming-Chung Lin, Tsui-Shan Wei, Hui-Ching Lin, Chia-Cheng Chang, Chung-Hsi Hsing
BACKGROUND: Peripheral innate immune response may induce sickness behavior through activating microglia, excessive cytokines production, and neuroinflammation. Dexmedetomidine (Dex) has anti-inflammatory effect. We investigated the effects of Dex on lipopolysaccharide (LPS)-induced neuroinflammation and sickness behavior in mice. MATERIALS AND METHODS: BALB/c mice were intraperitoneally (i.p.) injected with Dex (50 ug/kg) or vehicle. One hour later, the mice were injected (i...
2018: PloS One
https://www.readbyqxmd.com/read/29351248/a-comprehensive-study-of-a-micro-channel-heat-sink-using-integrated-thin-film-temperature-sensors
#5
Tao Wang, Jiejun Wang, Jian He, Chuangui Wu, Wenbo Luo, Yao Shuai, Wanli Zhang, Xiancai Chen, Jian Zhang, Jia Lin
A micro-channel heat sink is a promising cooling method for high power integrated circuits (IC). However, the understanding of such a micro-channel device is not sufficient, because the tools for studying it are very limited. The details inside the micro-channels are not readily available. In this letter, a micro-channel heat sink is comprehensively studied using the integrated temperature sensors. The highly sensitive thin film temperature sensors can accurately monitor the temperature change in the micro-channel in real time...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29351209/the-prognostic-significance-of-histone-demethylase-utx-in-esophageal-squamous-cell-carcinoma
#6
Shau-Hsuan Li, Hung-I Lu, Wan-Ting Huang, Wan-Yu Tien, Ya-Chun Lan, Wei-Che Lin, Hsin-Ting Tsai, Chang-Han Chen
The dysregulation of the ubiquitously transcribed TPR gene on the X chromosome (UTX) has been reported to be involved in the oncogenesis of several types of cancers. However, the expression and significance of UTX in esophageal squamous cell carcinoma (ESCC) remains largely undetermined. Immunohistochemistry was performed in 106 ESCC patients, and correlated with clinicopathological features and survival. The functional role of UTX in ESCC cells was determined by UTX-mediated siRNA. Univariate analyses showed that high UTX expression was associated with superior overall survival (OS, p = 0...
January 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29351154/predictors-of-health-related-quality-of-life-in-irritable-bowel-syndrome-patients-compared-with-healthy-individuals
#7
Raymond Addante, Bruce Naliboff, Wendy Shih, Angela P Presson, Kirsten Tillisch, Emeran A Mayer, Lin Chang
BACKGROUND: Irritable bowel syndrome (IBS) reduces health-related quality of life (HRQOL). It is unclear how having IBS modifies the impact of gastrointestinal (GI), psychosocial, and somatic symptom variables on HRQOL compared with healthy controls (HCs). AIMS: (1) Determine psychosocial, somatic, and physical status variables most predictive of HRQOL in IBS and HCs and (2) determine if IBS status modifies relationships between predictive factors and HRQOL. METHODS: IBS patients and HCs completed validated questionnaires measuring GI symptoms, psychosocial/somatic variables, and physical [physical component score (PCS)] and mental [mental component score (MCS)] HRQOL via the Short-Form-36...
January 18, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29350999/sex-differences-in-abdominal-aortic-aneurysms
#8
Austin Boese, Lin Chang, Ke-Jie Yin, Y Eugene Chen, Jean-Pyo Lee, Milton H Hamblin
Abdominal aortic aneurysm (AAA) is a vascular disorder with a high case fatality rate in the instance of rupture. AAA is a multifactorial disease and the etiology is still not fully understood. AAA is more likely to occur in men, but women have a greater risk of rupture and worse prognosis. Women are reportedly protected against AAA possibly by premenopausal levels of estrogen and are, on average, diagnosed at older ages than men. Here, we review the current body of research on AAA pathophysiology in humans, animal models, and cultured cells, with an emphasis on sex differences and sex steroid hormone signaling...
January 19, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29350471/variability-assessment-of-90-salivary-proteins-in-intra-day-and-inter-day-samples-from-healthy-donors-by-multiple-reaction-monitoring-mass-spectrometry
#9
Yung-Chin Hsiao, Lichieh Julie Chu, Yi-Ting Chen, Lang-Ming Chi, Kun-Yi Chien, Wei-Fan Chiang, Ya-Ting Chang, Szu-Fan Chen, Wei-Shun Wang, Yao-Ning Chuang, Shih-Yu Lin, Chih-Yen Chien, Kai-Ping Chang, Yu-Sun Chang, Jau-Song Yu
PURPOSE: Saliva is an attractive sample source for the biomarker-based testing of several diseases, especially oral cancer. Here, we sought to apply multiplexed LC-MRM-MS to precisely quantify 90 disease-related proteins and assess their intra- and inter-individual variability in saliva samples from healthy donors. EXPERIMENTAL DESIGN: We developed two multiplexed LC-MRM-MS assays for 122 surrogate peptides representing a set of disease-related proteins. Saliva samples were collected from 10 healthy volunteers at three different time points (Day 1 morning and afternoon, and Day 2 morning)...
January 19, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29350006/-the-shor-term-clinical-outcomes-and-safety-of-extreme-lateral-interbody-fusion-combined-with-percutaneous-pedicle-screw-fixation-for-the-treatment-of-degenerative-lumbar-disease
#10
Xu-Dong Hu, Wei-Hu Ma, Wei-Yu Jiang, Chao-Yue Ruan, Yun-Lin Chen
OBJECTIVE: To evaluate the early efficacy and safety of extreme lateral interbody fusion (XLIF) combined with percutaneous pedicle screw fixation for lumbar degenerative disease. METHODS: From January 2013 to June 2014, 13 patients with degenerative lumbar disease were treated with XLIF combined with percutaneous pedicle screw fixation, including 8 cases of lumbar instability, 5 cases of mild to moderate lumbar spondylolisthesis;there were 5 males and 8 females, aged from 56 to 73 years with an average of 62...
February 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349991/-effects-of-creating-a-tunnel-through-intercondylar-fossa-under-arthroscopy-for-the-treatment-of-complex-tears-at-the-medial-meniscus-posterior-horn
#11
Ling-Dai Dong, Chang-Jian Bing, Jian-Lin Li, Yue Cai
OBJECTIVE: To discuss the advantages of the arthroscopic treatment for complex tears of the medial meniscus posterior horn by creating a tunnel passageway through the intercondylar fossa. METHODS: All 127 patients including 24 males and 103 females with complex tears at the medial meniscus posterior horn were reviewed. The age of all patients ranged from 45 to 78 years old, with an average of 67 years old. All 127 patients were treated with partial meniscectomy, in which 112 patients were treated with partial meniscectomy smoothly with three incisions (anterior medial incision, anterior lateral incision, high anterior lateral incision), and 15 patients were treated with four incisions (anterior medial incision, anterior lateral incision, high anterior lateral incision, posterior medial incision)...
April 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29349803/assessment-of-mitral-annulus-and-mitral-leaflet-in-nonvalvular-atrial-fibrillation-patients-with-various-degrees-of-mitral-regurgitation-real-time-3d-transesophageal-echocardiography
#12
Yongjuan Luo, Yanbo Zhu, Xin Guan, Yunjia Lin
AIM: To study the changes of mitral valve (MV) in patients with nonvalvular atrial fibrillation (NVAF)-related mitral regurgitation (MR) and the relationship between MV parameters and the enlarged left atrium (LA). MATERIALS AND METHODS: A total of 43 patients with NVAF were divided into two groups: (1) the MR1 group with mild MR and (2) the MR2 group with moderate-to-severe MR. Real time 3D transesophageal echocardiography (TEE) was performed to detect the structure of MV...
January 19, 2018: Echocardiography
https://www.readbyqxmd.com/read/29349655/total-body-irradiation-tremendously-impair-the-proliferation-differentiation-and-chromosomal-integrity-of-bone-marrow-derived-mesenchymal-stromal-stem-cells
#13
Wen-Jyi Lo, Chiao-Lin Lin, Yu-Chien Chang, Li-Yuan Bai, Chen-Yuan Lin, Ji-An Liang, Long-Yuan Li, Ling-Min Chao, Chang-Fang Chiu, Chuan-Mu Chen, Su-Peng Yeh
Total body irradiation (TBI) is frequently used in hematopoietic stem cell transplantation (HSCT) and is associated with many complications due to radiation injury to the normal cells, including normal stem cells. Nevertheless, the effects of TBI on the mesenchymal stromal stem cell (MSC) are not fully understood. Bone marrow-derived MSCs (BM-MSCs) isolated from normal adults were irradiated with 200 cGy twice daily for consecutive 3 days, a regimen identical to that used in TBI-conditioning HSCT. The characteristics, differentiation potential, cytogenetics, hematopoiesis-supporting function, and carcinogenicity of the irradiated BM-MSCs were then compared to the non-irradiated control...
January 18, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29349498/plasma-metabolites-associated-with-type-2-diabetes-in-a-swedish-population-a-case-control-study-nested-in-a-prospective-cohort
#14
Lin Shi, Carl Brunius, Marko Lehtonen, Seppo Auriola, Ingvar A Bergdahl, Olov Rolandsson, Kati Hanhineva, Rikard Landberg
AIMS/HYPOTHESIS: The aims of the present work were to identify plasma metabolites that predict future type 2 diabetes, to investigate the changes in identified metabolites among individuals who later did or did not develop type 2 diabetes over time, and to assess the extent to which inclusion of predictive metabolites could improve risk prediction. METHODS: We established a nested case-control study within the Swedish prospective population-based Västerbotten Intervention Programme cohort...
January 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29348465/publisher-correction-efhd2-promotes-epithelial-to-mesenchymal-transition-and-correlates-with-postsurgical-recurrence-of-stage-i-lung-adenocarcinoma
#15
Chi-Chen Fan, Wei-Chung Cheng, Yu-Chuen Huang, Yuh-Pyng Sher, Nia-Jhen Liou, Yu-Chuan Chien, Pei-Shan Lin, Pei-Syuan Lin, Chung-Hsuan Chen, Wei-Chao Chang
A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347208/colloid-colloid-hydrodynamic-interaction-around-a-bend-in-a-quasi-one-dimensional-channel
#16
Christopher Liepold, Ryan Zarcone, Tibor Heumann, Stuart A Rice, Binhua Lin
We report a study of how a bend in a quasi-one-dimensional (q1D) channel containing a colloid suspension at equilibrium that exhibits single-file particle motion affects the hydrodynamic coupling between colloid particles. We observe both structural and dynamical responses as the bend angle becomes more acute. The structural response is an increasing depletion of particles in the vicinity of the bend and an increase in the nearest-neighbor separation in the pair correlation function for particles on opposite sides of the bend...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346572/analysis-of-experience-regulated-transcriptome-and-imprintome-during-critical-periods-of-mouse-visual-system-development-reveals-spatiotemporal-dynamics
#17
Chi-Lin Hsu, Chih-Hsuan Chou, Shih-Chuan Huang, Chia-Yi Lin, Meng-Ying Lin, Chun-Che Tung, Chun-Yen Lin, Ivan Pochou Lai, Yan-Fang Zou, Neil A Youngson, Shau-Ping Lin, Chang-Hao Yang, Shih-Kuo Chen, Susan Shur-Fen Gau, Hsien-Sung Huang
Visual system development is light-experience dependent, which strongly implicates epigenetic mechanisms in light-regulated maturation. Among many epigenetic processes, genomic imprinting is an epigenetic mechanism through which monoallelic gene expression occurs in a parent-of-origin-specific manner. It is unknown if genomic imprinting contributes to visual system development. We profiled the transcriptome and imprintome during critical periods of mouse visual system development under normal- and dark-rearing conditions using B6/CAST F1 hybrid mice...
January 15, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29346078/long-term-high-air-pollution-exposure-induced-metabolic-adaptations-in-traffic-policemen
#18
Chaochao Tan, Yupeng Wang, Mingyue Lin, Zhu Wang, Li He, Zhiyi Li, Yu Li, Keqian Xu
OBJECTIVE: To assess the adverse physiological changes induced by long-term exposure to PM2.5. METHODS: Totally 183 traffic policemen and 88 office policemen as the control group, were enrolled in this study. The concentrations of PM2.5 in both the working places of traffic and office policemen were obtained. Detailed personal questionnaires and conventional laboratory tests including hematology, fasting blood glucose, blood lipids, liver, kidney, immunity and tumor-related markers were conducted on all participants of this study...
January 5, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29345850/effects-of-glutaraldehyde-didecyldimethylammonium-bromide-combined-disinfectant-on-the-cell-surface-of-staphylococcus-aureus
#19
Wenshu Lin, Jialin Yi, Yuelin Zhang, Zhirui Deng, Qin Chen, Bing Niu
AIMS: The effects of a new glutaraldehyde-didecyldimethylammonium bromide combination disinfectant (GD) on the cell surface of Staphylococcus aureus, a representative Gram-positive bacterium, were investigated in this study. METHODS AND RESULTS: Results of bacterial surface structural analysis showed that GD significantly changed the bacterial morphology. The membrane fluidity decreased and outer membrane permeabilization increased after contact with GD. Furthermore, the integrity of the cytoplasmic membrane was destroyed by over 99% after exposure to GD for a short time...
January 18, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29345776/allyl-isothiocyanate-ameliorates-obesity-by-inhibiting-galectin-12
#20
Chia-Wen Lo, Chih-Sheng Chen, Ying-Chi Chen, Yu-An Hsu, Chi-Chun Huang, Ching-Yao Chang, Chao-Jen Lin, Cheng-Wen Lin, Hui-Ju Lin, Fu-Tong Liu, Lei Wan
SCOPE: The aim of this study was to investigate the signaling pathways by which allyl isothiocyanate (AITC) reduces adipocyte differentiation and the efficacy of AITC in suppressing galectin-12 levels as a therapeutic for high fat diet (HFD)-induced obesity. METHODS AND RESULTS: AITC presents anti-adipogenic effects on 3T3-L1 cells by decreasing lipid droplet accumulation in a dose-dependent manner. AITC suppresses 3T3-L1 differentiation into adipocytes by decreasing galectin-12 expression and by down-regulating key adipogenic transcription factors...
January 18, 2018: Molecular Nutrition & Food Research
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