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https://www.readbyqxmd.com/read/28738658/an-ultrasensitive-chemiluminescence-aptasensor-for-thrombin-detection-based-on-iron-porphyrin-catalyzing-luminescence-desorbed-from-chitosan-modified-magnetic-oxide-graphene-composite
#1
Yuanling Sun, Yanhui Wang, Jianbo Li, Chaofan Ding, Yanna Lin, Weiyan Sun, Chuannan Luo
In this work, an ultrasensitive chemiluminescence (CL) aptasensor was prepared for thrombin detection based on iron porphyrin catalyzing luminol - hydrogen peroxide luminescence under alkaline conditions, and iron porphyrin was desorbed from chitosan modified magnetic oxide graphene composite (CS@Fe3O4@GO). Firstly, CS@Fe3O4@GO was prepared. CS@Fe3O4@GO has advantages of the good biocompatibility and positively charged on its surface of CS, the large specific surface area of GO and the easy separation characteristics of Fe3O4...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738592/a-unique-red-emitting-two-photon-fluorescent-probe-with-tumor-specificity-for-imaging-in-living-cells-and-tissues
#2
Xiuqi Kong, Baoli Dong, Nan Zhang, Chao Wang, Xuezhen Song, Weiying Lin
Tumor-specific imaging can provide an attractive approach for the early detection and prognosis of cancer, as well as the precise image-guided tumor-removal surgery. Herein, we describe a unique red-emitting two-photon fluorescent probe (N-BN) for tumor-specific imaging. N-BN utilized Nile Red as the red-emitting two-photon fluorophore and employed biotin as the tumor-specific ligand. In the presence of a variety of biomolecules or in different pH buffers, the fluorescence intensity of N-BN at 655nm showed no noticeable change...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28738283/visual-and-reversible-carbon-dioxide-sensing-enabled-by-doctor-blade-coated-macroporous-photonic-crystals
#3
Yi-Han Lin, Shing-Yi Suen, Hongta Yang
With significant impacts of carbon dioxide on global climate change, carbon dioxide sensing is of great importance. However, most of the existing sensing technologies are prone to interferences from carbon monoxide, or suffer from the use of sophisticated instruments. This research reports the development of reproducible carbon dioxide sensor using roll-to-roll compatible doctor blade coated three-dimensional macroporous photonic crystals. The pores are functionalized with amine groups to allow the reaction with carbon dioxide in the presence of humidity...
July 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28738278/well-dispersed-rhenium-nanoparticles-on-three-dimensional-carbon-nanostructures-efficient-catalysts-for-the-reduction-of-aromatic-nitro-compounds
#4
Pitchaimani Veerakumar, Pounraj Thanasekaran, King-Chuen Lin, Shang-Bin Liu
Rhenium nanoparticles (ReNPs) supported on ordered mesoporous carbon (OMC) as a catalyst (Re/OMC) through a solvent-evaporation induced self-assembly (ELSA) method were prepared. The synthesized heterogonous catalyst was fully characterized using X-ray diffraction, field emission transmission electron microscopy, N2 sorption, metal dispersion, thermogravimetric analysis, Raman, Fourier-transform infrared, and X-ray photon spectroscopies. In addition, the catalyst was applied to reduce the aromatic nitro compounds (ANCs) for the first time in aqueous media and the reactions were monitored by following the intensity changes in the UV-vis absorption spectra with respect to time...
July 18, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28738126/comparing-plasma-phospho-tau-total-tau-and-phospho-tau-total-tau-ratio-as-acute-and-chronic-traumatic-brain-injury-biomarkers
#5
Richard Rubenstein, Binggong Chang, John K Yue, Allen Chiu, Ethan A Winkler, Ava M Puccio, Ramon Diaz-Arrastia, Esther L Yuh, Pratik Mukherjee, Alex B Valadka, Wayne A Gordon, David O Okonkwo, Peter Davies, Sanjeev Agarwal, Fan Lin, George Sarkis, Hamad Yadikar, Zhihui Yang, Geoffrey T Manley, Kevin K W Wang, Shelly R Cooper, Kristen Dams-O'Connor, Allison J Borrasso, Tomoo Inoue, Andrew I R Maas, David K Menon, David M Schnyer, Mary J Vassar
Importance: Annually in the United States, at least 3.5 million people seek medical attention for traumatic brain injury (TBI). The development of therapies for TBI is limited by the absence of diagnostic and prognostic biomarkers. Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated. Objective: To examine the associations between plasma P-tau and total-tau (T-tau) levels and injury presence, severity, type of pathoanatomic lesion (neuroimaging), and patient outcomes in acute and chronic TBI...
July 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28737996/integrating-palliative-and-oncology-care-for-patients-with-advanced-cancer-a-quality-improvement-intervention
#6
Laura C Hanson, Frances Collichio, Stephen A Bernard, William A Wood, Matt Milowsky, Erin Burgess, Crista J Creedle, Summer Cheek, Lydia Chang, Bhisham Chera, Alexandra Fox, Feng-Chang Lin
BACKGROUND: Practice guidelines recommend palliative care for patients with advanced cancer, but gaps in access and quality of care persist. OBJECTIVE: To increase goals-of-care (GOC) communication for hospitalized patients with Stage IV cancer. METHODS: An interdisciplinary team designed a quality improvement intervention to enhance oncology palliative care, including training in communication skills and triggers for palliative care consults...
July 24, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28737830/role-of-triosephosphate-isomerase-and-downstream-functional-genes-on-gastric-cancer
#7
Tingting Chen, Zhigang Huang, Yunxiao Tian, Haiwei Wang, Ping Ouyang, Haoqin Chen, Lili Wu, Bode Lin, Rongwei He
Triosephosphate isomerase (TPI) is highly expressed in many types of human tumors and is involved in migration and invasion of cancer cells. However, TPI clinicopathological significance and malignant function in gastric cancer (GC) have not been well defined. The present study aimed to examine TPI expression in GC tissue and its biological functions. Furthermore, we investigated its downstream genes by gene chip technology. Our results showed that TPI expression was higher in gastric cancer tissues than adjacent tissues, although no statistical differences were found between TPI expression and clinicopathological factors...
July 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28737735/the-putative-histone-methyltransferase-dot1-regulates-aflatoxin-and-pathogenicity-attributes-in-aspergillus-flavus
#8
Linlin Liang, Yinghang Liu, Kunlong Yang, Guinan Lin, Zhangling Xu, Huahui Lan, Xiuna Wang, Shihua Wang
Lysine methyltransferases transfer methyl groups in specific lysine sites, which regulates a variety of important biological processes in eukaryotes. In this study, we characterized a novel homolog of the yeast methyltransferase DOT1 in A. flavus, and observed the roles of dot1 in A. flavus. Deletion of dot1 showed a significant decrease in conidiation, but an increase in sclerotia formation. A change in viability to multiple stresses was also found in the Δdot1 mutant. Additionally, aflatoxin (AF) production was found severely impaired in the Δdot1 mutant...
July 24, 2017: Toxins
https://www.readbyqxmd.com/read/28737731/study-on-chemical-profile-and-neuroprotective-activity-of-myrica-rubra-leaf-extract
#9
Pinghong Chen, Xianzong Lin, Ching-Hsu Yang, Xu Tang, Yu-Wei Chang, Weibing Zheng, Lianzhong Luo, Changan Xu, Yung-Husan Chen
The chemical profile of Myrica rubra (a native species in China) leaf extract was investigated by UPLC-PDA-HRMS, and the neuroprotective activity of two characteristic constituents, myricanol and myricetrin, was evaluated with N2a cells using H₂O₂-inducedoxidative challenge through a series of methods, e.g., MTT assay, ROS assay and [Ca(2+)]i assay. Among the 188 constituents detected in the extract of Myrica rubra leaf, 116 were identified definitely or tentatively by the comprehensive utilization of precise molecular weight and abundant multistage fragmentation information obtained by quadrupole orbitrap mass spectrometry...
July 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28737136/issue-highlights
#10
Lin Chang
No abstract text is available yet for this article.
August 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28736958/intraoperative-indocyanine-green-fluorescent-angiography-assisted-modified-superior-gluteal-artery-perforator-flap-for-reconstruction-of-sacral-pressure-sores
#11
Chun-Kai Chang, Chien-Ju Wu, Chun-Yu Chen, Chi-Yu Wang, Tzi-Shiang Chu, Kuo-Feng Hsu, Han-Ting Chiu, Hung-Hui Liu, Chang-Yi Chou, Chih-Hsin Wang, Chin-Ta Lin, Niann-Tzyy Dai, Yuan-Sheng Tzeng
Pressure sores are often observed in patients who are bedridden. They can be a severe problem not only for patients and their caregivers but also for plastic surgeons. Here, we describe a new method of superior gluteal artery perforator flap harvesting and anchoring with the assistance of intraoperative indocyanine green fluorescent angiography. In this report, we describe the procedure and outcomes for 19 patients with grades III and IV sacral pressure sores who underwent the operation between September 2015 and November 2016...
July 23, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28736952/validation-of-the-albi-grade-based-integrated-model-as-a-predictor-for-sorafenib-failed-hepatocellular-carcinoma
#12
Pei-Chang Lee, Yi-Tzen Chen, Yee Chao, Teh-Ia Huo, Chung-Pin Li, Chien-Wei Su, Mei-Hsuan Lee, Ming-Chih Hou, Fa-Yauh Lee, Han-Chieh Lin, Yi-Hsiang Huang
BACKGROUND AND AIMS: Sorafenib is the standard treatment for advanced hepatocellular carcinoma (HCC) but is challenging after treatment failure. Appropriate criteria for enrolling patients into second-line trials are still limited. In this study, we aimed to establish more objective criteria based on Albumin-Bilirubin (ALBI) grade to select patients with better post-progression survival (PPS) for second-line treatment. METHODS: Consecutive 404 advanced HCC patients receiving sorafenib were retrospectively enrolled...
July 24, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28736588/the-regulation-of-the-practice-of-acupuncture-by-physicians-in-the-united-states
#13
Katerina Lin, Cynthia Tung
Introduction: The landscape of acupuncture regulation has greatly evolved since the National Institutes of Health Consensus Statement in 1997. In recent decades, acupuncture treatment has become increasingly integrated with conventional medical care. Healthcare practitioners often utilize acupuncture as an adjunctive therapy to help alleviate symptoms of many conditions, such as nausea and pain. The popularity of this complementary and alternative modality has elevated the importance and urgency for states to regulate its practice and safety...
June 1, 2017: Medical Acupuncture
https://www.readbyqxmd.com/read/28736523/sub-minimum-inhibitory-concentrations-of-rhubarb-water-extracts-inhibit-streptococcus-suis-biofilm-formation
#14
Wen-Ya Ding, Yan-Hua Li, He Lian, Xiao-Yu Ai, Yu-Lin Zhao, Yan-Bei Yang, Qiang Han, Xin Liu, Xue-Ying Chen, Zhonggui He
Streptococcus suis is one of the most important swine pathogens, which can cause persistent infection by forming biofilms. In this study, sub-minimum inhibitory concentration (sub-MIC) of rhubarb water extracts were found to inhibit biofilm formation. Two-component signal transduction systems (TCSs), transcriptional regulators, and DNA binding proteins were compared under two conditions: (1) cells treated with sub-MIC rhubarb water extracts and (2) untreated cells. Using an isobaric tags for relative and absolute quantitation (iTRAQ) strategy, we found that TCSs constituent proteins of histidine kinase and response regulator were significantly down-regulated...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28736377/-association-of-ras-mutations-in-circulating-cell-free-dna-in-the-plasma-with-clinicopathological-features-of-colorectal-cancer
#15
Jing Wu, Li-Rong Zhao, Xiu-Qiang Lin, Fen Feng, Yong-Chang Chen, Wei-Ying Deng, Yan-Ming Deng, Wei Wang
OBJECTIVE: To detect RAS mutations in the circulating cell-free DNA (cfDNA) in the plasma and explore the their correlation with the clinicopathological features in patients with colorectal cancer. METHODS: Real-time PCR was used to detect RAS mutations in plasma cfDNA and matched tumor tissue DNA samples from 71 colorectal cancer patients. The correlation of RAS mutations with the clinicopathological features of the patients were analyzed. RESULTS: Of the 71 patients with colorectal cancer, 23 (32...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28736371/-multifocal-electroretinography-for-therapeutic-effect-evaluation-of-intravitreal-injection-lucentis-for-wet-age-related-macular-degeneration
#16
Rui-Hong Ju, Man-Sha He, Jin-Tong Hou, Meng-Yuan Li, Jing-Lin Zhang, Zhe-Ming Wu
OBJECTIVE: To evaluate the changes in retinal functions using multifocal electroretinography (mfERG) following intravitreal injection of Lucentis for treatment of wet age-related macular degeneration. METHODS: This prospective study was conducted in 14 patients (9 men and 5 women, 14 eyes) with wet age-related macular degeneration receiving treatment with intravitreal injections of ranibizumab (Lucentis) in our hospital between October, 2014 and January, 2016. All the patients received the treatment following a 1+PRN protocol and after the initial injection, the patients were followed up monthly for 6 months to decide if additional injections were needed...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28736364/-angiotensin-1-7-protects-cardiac-myocytes-against-high-glucose-induced-injury-by-inhibiting-clc-3-chloride-channels
#17
Shao-Ai Ccai, Jing-Fu Chen, Mei-Ji Chen, Jian-Cong Lin, Jian-Qiang Feng, Kai Lin, Xi-Mei Zhi, Wei-Jie Zhang, Wen Wu
OBJECTIVE: To explore whether angiotensin-(1-7) [Ang-(1-7)] protects cardiac myocytes against high glucose (HG)-induced injury by inhibiting ClC-3 chloride channels. METHOD: H9c2 cardiac cells were exposed to 35 mmol/L glucose for 24 h to establish a cell injury model. The cells were treated with Ang-(1-7) or the inhibitor of chloride channel (NPPB) in the presence of HG for 24 h to observe the changes in HG-induced cell injury. Cell counter kit 8 (CCK-8) assay was used to test the cell viability, and the morphological changes of the apoptotic cells were detected using Hoechst 33258 staining and fluorescent microscopy...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28736223/semaphorin-3a-in-ankylosing-spondylitis
#18
Hsien-Tzung Liao, Yuh-Feng Lin, Chung-Tei Chou, Chang-Youh Tsai
BACKGROUND/PURPOSE: To determine serum semaphorin 3A (Sema 3A) levels in ankylosing spondylitis (AS). METHODS: Serum Sema 3A was measured in 46 AS patients and 30 healthy controls (HCs). For the patients, we recorded demographic data, disease activity, functional index & global assessment, detected human leukocyte antigen-B27 (HLA-B27), and measured erythrocyte sedimentation rate (ESR) & C-reactive protein (CRP). RESULTS: Sema 3A was higher in AS patients than in HCs (3...
July 14, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28736056/variability-of-glycated-hemoglobin-levels-in-the-first-year-post-renal-transplantation-in-patients-without-diabetes
#19
Ana Laura Pimentel, Joíza Lins Camargo
BACKGROUND: Glycated hemoglobin (HbA1c) is an alternative test used for the diagnosis and monitoring of diabetes in kidney transplant recipients. Immunosuppressive drugs are the most important risk factors related with changes in the glucose metabolism after transplant. It is still unknown if they impact on the variability of HbA1c. We assessed the variability of HbA1c levels in a group of renal transplant recipients without diabetes during the first year after transplant. METHODS: We estimated the variability of HbA1c in a group of 95 Brazilian kidney transplant recipients...
July 20, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28735778/yoga-for-military-veterans-with-chronic-low-back-pain-a-randomized-clinical-trial
#20
Erik J Groessl, Lin Liu, Douglas G Chang, Julie L Wetherell, Jill E Bormann, J Hamp Atkinson, Sunita Baxi, Laura Schmalzl
INTRODUCTION: Chronic low back pain (cLBP) is prevalent, especially among military veterans. Many cLBP treatment options have limited benefits and are accompanied by side effects. Major efforts to reduce opioid use and embrace nonpharmacological pain treatments have resulted. Research with community cLBP patients indicates that yoga can improve health outcomes and has few side effects. The benefits of yoga among military veterans were examined. DESIGN: Participants were randomized to either yoga or delayed yoga treatment in 2013-2015...
July 17, 2017: American Journal of Preventive Medicine
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