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Cardiac progenitor

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https://www.readbyqxmd.com/read/29777508/endothelial-progenitor-cells-in-heart-failure-an-authentic-expectation-for-potential-future-use-and-a-lack-of-universal-definition
#1
REVIEW
Andie H Djohan, Ching-Hui Sia, Poay Sian Lee, Kian-Keong Poh
Congestive heart failure (CHF) is a prevalent disease (especially among the elderly) with high mortality and morbidity rates. The pathological hallmark of CHF is a loss of cardiomyocytes leading to cardiac fibrosis and dysfunctional cardiac remodeling, which culminates in organ failure. Endothelial progenitor cells (EPCs) are bone marrow-derived cells that contribute to maintenance of the integrity of endothelial wall and protect ischemic myocardium through forming new blood vessels (vasculogenesis) or proliferation of pre-existing vasculature (angiogenesis)...
May 17, 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29773058/non-cardiomyocytes-in-heart-regeneration
#2
Jie Feng, Yandong Li, Yu Nie
Heart failure represents a challenging clinical and public health problem and is associated with significant morbidity and mortality. Mechanistically, loss of cardiomyocytes leads to decompensated ventricular remodeling, which eventually progressed to cardiac failure. Regenerative medicine aimed to supplement functional cardiomyocytes is supposedly a promising approach for the effective treatment of heart failure. Over the past decades, investigations on heart regeneration have revealed the regulating networks of cardiomyocyte proliferation...
May 17, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29772252/sulfiredoxin-1-enhances-cardiac-progenitor-cell-survival-against-oxidative-stress-via-the-upregulation-of-the-erk-nrf2-signal-pathway
#3
Xiuchun Li, Pan He, Xiaoliang Wang, Shuning Zhang, Neil Devejian, Edward Bennett, Chuanxi Cai
Cardiac stem/progenitor cells (CPCs) have recently emerged as a potentially transformative regenerative medicine to repair the infarcted heart. However, the limited survival of donor cells is one of the major challenges for CPC therapy. Our recent research effort on preconditioning human CPCs (hCPCs) with cobalt protoporphyrin (CoPP) indicated that sulfiredoxin-1 (SRXN1) is upregulated upon preconditioning aldehyde dehydrogenase bright hCPCs (ALDHbr -hCPCs) with CoPP. Further studies demonstrated that overexpressing SRXN1 enhanced the survival capacity for ALDHbr -hCPCs...
May 14, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29764980/interplay-of-cell-cell-contacts-and-rhoa-mrtf-a-signaling-regulates-cardiomyocyte-identity
#4
Tatjana Dorn, Jessica Kornherr, Elvira I Parrotta, Dorota Zawada, Harold Ayetey, Gianluca Santamaria, Laura Iop, Elisa Mastantuono, Daniel Sinnecker, Alexander Goedel, Ralf J Dirschinger, Ilaria My, Svenja Laue, Tarik Bozoglu, Christian Baarlink, Tilman Ziegler, Elisabeth Graf, Rabea Hinkel, Giovanni Cuda, Stefan Kääb, Andrew A Grace, Robert Grosse, Christian Kupatt, Thomas Meitinger, Austin G Smith, Karl-Ludwig Laugwitz, Alessandra Moretti
Cell-cell and cell-matrix interactions guide organ development and homeostasis by controlling lineage specification and maintenance, but the underlying molecular principles are largely unknown. Here, we show that in human developing cardiomyocytes cell-cell contacts at the intercalated disk connect to remodeling of the actin cytoskeleton by regulating the RhoA-ROCK signaling to maintain an active MRTF/SRF transcriptional program essential for cardiomyocyte identity. Genetic perturbation of this mechanosensory pathway activates an ectopic fat gene program during cardiomyocyte differentiation, which ultimately primes the cells to switch to the brown/beige adipocyte lineage in response to adipogenesis-inducing signals...
May 15, 2018: EMBO Journal
https://www.readbyqxmd.com/read/29760740/current-progress-in-the-rejuvenation-of-aging-stem-progenitor-cells-for-improving-the-therapeutic-effectiveness-of-myocardial-repair
#5
REVIEW
Gurleen Kaur, Chuanxi Cai
Ischemic heart disease affects a majority of people, especially elderly patients. Recent studies have utilized autologous adult stem/progenitor cells as a treatment option to heal cardiac tissue after myocardial infarction. However, donor cells from aging patients are more likely to be in a senescent stage. Rejuvenation is required to reverse the damage levied by aging and promote a youthful phenotype. This review aims to discuss current strategies that are effective in rejuvenating aging cardiac stem cells and represent novel therapeutic methods to treat the aging heart...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29743563/cell-therapy-trials-for-heart-regeneration-lessons-learned-and-future-directions
#6
REVIEW
Philippe Menasché
The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy have been assessed in several clinical trials. These trials can be categorized as those using noncardiac stem cells, including mesenchymal stem cells, and those using cardiac-committed cells, including KIT+ cardiac stem cells, cardiosphere-derived cells, and cardiovascular progenitor cells derived from embryonic stem cells. Although the safety of cell therapies has been consistently reported, their efficacy remains more elusive...
May 9, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29728415/crispr-mediated-gene-editing-to-assess-the-roles-of-tet2-and-dnmt3a-in-clonal-hematopoiesis-and-cardiovascular-disease
#7
Soichi Sano, Kousei Ohshima, Ying Wang, Yasufumi Katanasaka, Miho Sano, Kenneth Walsh
<u>Rationale:</u> Clonal hematopoiesis has been associated with increased mortality and cardiovascular disease (CVD). This condition can arise from somatic mutations in pre-leukemic driver genes within hematopoietic stem/progenitor cells (HSPC). Approximately 40 candidate driver genes have been identified, but mutations in only one of these genes, Ten-Eleven Translocation-2 (TET2), has been shown to casually contribute to CVD in murine models. <u>Objective:</u> To develop a facile system to evaluate the disease characteristics of different clonal hematopoiesis driver genes using lentivirus vector and CRISPR/Cas9 methodology...
May 4, 2018: Circulation Research
https://www.readbyqxmd.com/read/29720615/characterizing-the-role-of-atrial-natriuretic-peptide-signaling-in-the-development-of-embryonic-ventricular-conduction-system
#8
Arun Govindapillai, Adam Hotchkiss, Mark Baguma-Nibasheka, Robert A Rose, Lucile Miquerol, Oliver Smithies, Nobuyo Maeda, Kishore B S Pasumarthi
Patients born with congenital heart defects frequently encounter arrhythmias due to defects in the ventricular conduction system (VCS) development. Although recent studies identified transcriptional networks essential for the heart development, there is scant information on the mechanisms regulating VCS development. Based on the association of atrial natriuretic peptide (ANP) expression with VCS forming regions, it was reasoned that ANP could play a critical role in differentiation of cardiac progenitor cells (CPCs) and cardiomyocytes (CMs) toward a VCS cell lineage...
May 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29719380/astragalus-polysaccharides-protect-cardiac-stem-and-progenitor-cells-by-the-inhibition-of-oxidative-stress-mediated-apoptosis-in-diabetic-hearts
#9
Wei Chen, Jing Ju, Yehong Yang, Hao Wang, Wenjie Chen, Xuelan Zhao, Hongying Ye, Yu Zhang
Introduction: Diabetic cardiomyopathy is characterized by an imbalance between myocyte death and regeneration mediated by the progressive loss of cardiac stem and progenitor cells (CSPCs) by apoptosis and necrosis due to the activation of oxidative stress with diabetes. In this study, we evaluated the beneficial effect of astragalus polysaccharides (APS) therapy on the protection of CSPCs through its antioxidative capacity in diabetic hearts. Materials and methods: Streptozotocin (STZ)-induced diabetic mice and heterozygous (SOD2+/-) knockout mice were employed and administered with APS...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29703984/author-correction-unravelling-the-effects-of-mechanical-physiological-conditioning-on-cardiac-adipose-tissue-derived-progenitor-cells-in-vitro-and-in-silico
#10
Aida Llucià-Valldeperas, Ramon Bragós, Carolina Soler-Botija, Santiago Roura, Carolina Gálvez-Montón, Cristina Prat-Vidal, Isaac Perea-Gil, Antoni Bayes-Genis
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29703749/rationale-and-design-of-the-concert-hf-combination-of-mesenchymal-and-c-kit-cardiac-stem-cells-as-regenerative-therapy-for-heart-failure-trial
#11
Roberto Bolli, Joshua M Hare, Keith L March, Carl J Pepine, James T Willerson, Emerson C Perin, Phillip C Yang, Timothy D Henry, Jay H Traverse, Raul D Mitrani, Aisha Khan, Ivonne H Schulman, Doris A Taylor, Darcy L DiFede, João A Lima, Atul R Chugh, John Loughran, Rachel W Vojvodic, Shelly L Sayre, Judy Bettencourt, Michelle Cohen, Lem Moyé, Ray F Ebert, Robert D Simari
<u>Rationale:</u> Autologous bone marrow (BM) mesenchymal stem cells (MSCs) and c-kit+ cardiac progenitor cells (CPCs) are two promising cell types being evaluated for patients with heart failure (HF) secondary to ischemic cardiomyopathy. No information is available in humans regarding the relative efficacy of MSCs and CPCs and whether their combination is more efficacious than either cell type alone. <u>Objective:</u> CONCERT-HF (Combination Of meseNchymal and c-kit+ Cardiac stEm cells as Regenerative Therapy for Heart Failure) is a Phase II trial aimed at elucidating these issues by assessing the feasibility, safety, and efficacy of transendocardial administration of autologous MSCs and CPCs, alone and in combination, in patients with HF caused by chronic ischemic cardiomyopathy (coronary artery disease and old myocardial infarction)...
April 27, 2018: Circulation Research
https://www.readbyqxmd.com/read/29696821/a-simple-antegrade-perfusion-method-for-isolating-viable-single-cardiomyocytes-from-neonatal-to-aged-mice
#12
Mariko Omatsu-Kanbe, Kengo Yoshioka, Ryo Fukunaga, Hironori Sagawa, Hiroshi Matsuura
The aim of this study was to establish a simple and reproducible antegrade perfusion method for isolating single viable mouse heart cells and to determine the standard practical protocols that are appropriate for mice of various ages. Antegrade perfusion was performed by injecting perfusate from near the apex of the left ventricle of the excised heart, the aorta of which was clamped, using an infusion pump. This could thoroughly perfuse the myocardium through the coronary circulation. All procedures were carried out on a prewarmed heater mat under a microscope, which allows for the processes of injection and perfusion to be monitored...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29695981/cardiac-restoration-stemming-from-the-placenta-tree-insights-from-fetal-and-perinatal-cell-biology
#13
REVIEW
Sveva Bollini, Antonietta R Silini, Asmita Banerjee, Susanne Wolbank, Carolina Balbi, Ornella Parolini
Efficient cardiac repair and ultimate regeneration still represents one of the main challenges of modern medicine. Indeed, cardiovascular disease can derive from independent conditions upsetting heart structure and performance: myocardial ischemia and infarction (MI), pharmacological cardiotoxicity, and congenital heart defects, just to name a few. All these disorders have profound consequences on cardiac tissue, inducing the onset of heart failure over time. Since the cure is currently represented by heart transplantation, which is extremely difficult due to the shortage of donors, much effort is being dedicated to developing innovative therapeutic strategies based on stem cell exploitation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29693711/telocytes-in-skeletal-cardiac-and-smooth-muscle-interstitium-morphological-and-functional-aspects
#14
REVIEW
Mirca Marini, Irene Rosa, Lidia Ibba-Manneschi, Mirko Manetti
Telocytes (TCs) represent a new distinct type of cells found in the stromal compartment of many organs, including the skeletal, cardiac and smooth muscles. TCs are morphologically defined as interstitial cells with a small cellular body from which arise very long (up to hundreds of micrometers) and thin moniliform processes (named telopodes) featuring the alternation of slender segments (called podomers) and small dilated portions (called podoms) accommodating some organelles. Although these stromal cells are mainly characterized by their ultrastructural traits, in the last few years TCs have been increasingly studied for their immunophenotypes, microRNA profiles, and gene expression and proteomic signatures...
April 25, 2018: Histology and Histopathology
https://www.readbyqxmd.com/read/29689192/hippo-signaling-plays-an-essential-role-in-cell-state-transitions-during-cardiac-fibroblast-development
#15
Yang Xiao, Matthew C Hill, Min Zhang, Thomas J Martin, Yuka Morikawa, Suya Wang, Alexander R Moise, Joshua D Wythe, James F Martin
During development, progenitors progress through transition states. The cardiac epicardium contains progenitors of essential non-cardiomyocytes. The Hippo pathway, a kinase cascade that inhibits the Yap transcriptional co-factor, controls organ size in developing hearts. Here, we investigated Hippo kinases Lats1 and Lats2 in epicardial diversification. Epicardial-specific deletion of Lats1/2 was embryonic lethal, and mutant embryos had defective coronary vasculature remodeling. Single-cell RNA sequencing revealed that Lats1/2 mutant cells failed to activate fibroblast differentiation but remained in an intermediate cell state with both epicardial and fibroblast characteristics...
April 23, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29688817/current-status-of-messenger-rna-delivery-systems
#16
Matthew G Stanton
Messenger RNA is emerging as a highly versatile biological construct for creation of impactful medicines. mRNA vaccines directed toward infectious disease and cancer are in clinical development with encouraging early reads on tolerability and efficacy. The use of mRNA to direct intense but transient expression of paracrine factors is finding utility in reprogramming progenitor cells for wound healing and cardiac regeneration and for stimulation of antitumor immune responses, at least preclinically as we await clinical results...
April 24, 2018: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/29688622/cardiac-progenitor-cells-the-matrix-has-you
#17
Clotilde Castaldo, Isotta Chimenti
Components of the cardiac extracellular matrix (ECM) are synthesized by residing cells and are continuously remodeled by them. Conversely, residing cells (including primitive cells) receive constant biochemical and mechanical signals from the ECM that modulate their biology. The pathological progression of heart failure affects all residing cells, inevitably causing profound changes in ECM composition and architecture that, in turn, impact on cell phenotypes. Any regenerative medicine approach must aim at sustaining microenvironment conditions that favor cardiogenic commitment of therapeutic cells and minimize pro-fibrotic signals, while conversely boosting the capacity of therapeutic cells to counteract adverse remodeling of the ECM...
April 24, 2018: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29676466/cardiac-progenitor-cell-ion-currents-revealing-a-little-more-on-the-lesser-known
#18
Farid G Khalafalla, Mark A Sussman
No abstract text is available yet for this article.
April 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29675777/inhibition-of-p16-ink4a-to-rejuvenate-aging-human-cardiac-progenitor-cells-via-the-upregulation-of-anti-oxidant-and-nf%C3%AE%C2%BAb-signal-pathways
#19
Roshni V Khatiwala, Shuning Zhang, Xiuchun Li, Neil Devejian, Edward Bennett, Chuanxi Cai
Autologous human cardiac stem/progenitor cell (hCPC) therapy is a promising treatment that has come into use in recent years for patients with cardiomyopathy. Though innovative in theory, a major hindrance to the practical application of this treatment is that the hCPCs of elderly patients, who are most susceptible to myocardial disease, are senescent and prone to cell death. Rejuvenating hCPCs from elderly patients may help overcome this obstacle, and can be accomplished by reversing entry into the cellular stage of senescence...
April 19, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29666070/gata4-dependent-differentiation-of-c-kit-derived-endothelial-cells-underlies-artefactual-cardiomyocyte-regeneration-in-the-heart
#20
Bryan D Maliken, Onur Kanisicak, Jason Karch, Hadi Khalil, Xing Fu, Justin G Boyer, Vikram Prasad, Yi Zheng, Jeffery D Molkentin
Background -While c-Kit+ adult progenitor cells were initially reported to produce new cardiomyocytes in the heart, recent genetic evidence suggests that such events are exceedingly rare. However, to determine if these rare events represent true de novo cardiomyocyte formation we deleted the necessary cardiogenic transcription factors Gata4 and Gata6 from c-Kit-expressing cardiac progenitor cells (CPCs). Methods - Kit allele-dependent lineage tracing and fusion analysis was performed in mice following simultaneous Gata4 and Gata6 cell-type specific deletion to examine rates of putative de novo cardiomyocyte formation from c-Kit+ cells...
April 17, 2018: Circulation
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