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Cardiac progenitor

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https://www.readbyqxmd.com/read/29146241/cardiac-progenitor-cells-activated-by-mitochondrial-delivery-of-resveratrol-enhance-the-survival-of-a-doxorubicin-induced-cardiomyopathy-mouse-model-via-the-mitochondrial-activation-of-a-damaged-myocardium
#1
Jiro Abe, Yuma Yamada, Takeda Atsuhito, Hideyoshi Harashima
It has been reported that transplanting native cells would lack efficiency without producing artificial cell-tissue, due to the exaggerated oxidative stress in doxorubicin-induced cardiomyopathy. We attempted to activate cardiac progenitor cells (CPCs) by delivering resveratrol to mitochondria using a mitochondrial drug delivery system (MITO-Porter system). We first evaluated the viability of H9c2 cells (a cardio myoblast cell line) after doxorubicin treatment, where H9c2 cells were co-cultured with or without the mitochondria activated CPCs (referred to herein as MITO cell)...
November 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29141446/myocardial-reparative-functions-of-exosomes-from-mesenchymal-stem-cells-are-enhanced-by-hypoxia-treatment-of-the-cells-via-transferring-microrna-210-in-an-nsmase2-dependent-way
#2
Jinyun Zhu, Kai Lu, Ning Zhang, Yun Zhao, Qunchao Ma, Jian Shen, Yinuo Lin, Pingping Xiang, Yaoliang Tang, Xinyang Hu, Jinghai Chen, Wei Zhu, Keith A Webster, Jian'an Wang, Hong Yu
Hypoxia treatment enhances paracrine effect of mesenchymal stem cells (MSCs). The aim of this study was to investigate whether exosomes from hypoxia-treated MSCs (Exo(H)) are superior to those from normoxia-treated MSCs (Exo(N)) for myocardial repair. Mouse bone marrow-derived MSCs were cultured under hypoxia or normoxia for 24 h, and exosomes from conditioned media were intramyocardially injected into infarcted heart of C57BL/6 mouse. Exo(H) resulted in significantly higher survival, smaller scar size and better cardiac functions recovery...
November 16, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29138752/the-effect-of-granulocyte-colony-stimulating-factor-on-the-progression-of-atherosclerosis-in-animal-models-a-meta-analysis
#3
REVIEW
Manli Liu, Kejian Liu, Dongdong Chen, Hongzhi Chen, Kunming Sun, Xinxin Ju, Jiaojiao Lan, Yang Zhou, Weishan Wang, Lijuan Pang
Background: Atherosclerosis is a common inflammatory disease. Stem cell and endothelial progenitor cell treatments can improve cardiac function after myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) is a mobilisation agent, mobilising stem cells from the bone marrow to circulation in the blood. G-CSF may constitute a treatment of atherosclerosis. We have conducted meta-analysis to evaluate the current evidence for the effect of G-CSF on the progression of atherosclerosis in animal models and to provide reference for preclinical experiments and future human clinical trials of atherosclerosis treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29131159/enhancing-the-precision-of-genetic-lineage-tracing-using-dual-recombinases
#4
Lingjuan He, Yan Li, Yi Li, Wenjuan Pu, Xiuzhen Huang, Xueying Tian, Yue Wang, Hui Zhang, Qiaozhen Liu, Libo Zhang, Huan Zhao, Juan Tang, Hongbin Ji, Dongqing Cai, Zhibo Han, Zhongchao Han, Yu Nie, Shengshou Hu, Qing-Dong Wang, Ruilin Sun, Jian Fei, Fengchao Wang, Ting Chen, Yan Yan, Hefeng Huang, William T Pu, Bin Zhou
The Cre-loxP recombination system is the most widely used technology for in vivo tracing of stem or progenitor cell lineages. The precision of this genetic system largely depends on the specificity of Cre recombinase expression in targeted stem or progenitor cells. However, Cre expression in nontargeted cell types can complicate the interpretation of lineage-tracing studies and has caused controversy in many previous studies. Here we describe a new genetic lineage tracing system that incorporates the Dre-rox recombination system to enhance the precision of conventional Cre-loxP-mediated lineage tracing...
November 13, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29123530/human-cardiac-derived-stem-progenitor-cells-fine-tune-monocyte-derived-descendants-activities-toward-cardiac-repair
#5
Noémie Dam, Hocine Rachid Hocine, Itziar Palacios, Olga DelaRosa, Ramón Menta, Dominique Charron, Armand Bensussan, Hicham El Costa, Nabila Jabrane-Ferrat, Wilfried Dalemans, Eleuterio Lombardo, Reem Al-Daccak
Cardiac repair following MI relies on a finely regulated immune response involving sequential recruitment of monocytes to the injured tissue. Monocyte-derived cells are also critical for tissue homeostasis and healing process. Our previous findings demonstrated the interaction of T and natural killer cells with allogeneic human cardiac-derived stem/progenitor cells (hCPC) and suggested their beneficial effect in the context of cardiac repair. Therefore, we investigated here whether monocytes and their descendants could be also modulated by allogeneic hCPC toward a repair/anti-inflammatory phenotype...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29122939/to-seek-the-holy-grail-of-cardiac-progenitor-cells-an-opera-in-four-acts
#6
EDITORIAL
A J Marian
No abstract text is available yet for this article.
November 10, 2017: Circulation Research
https://www.readbyqxmd.com/read/29118944/cardiac-progenitor-cells-application-in-cardiovascular-disease
#7
REVIEW
Hassan Amini, Jafar Rezaie, Armin Vosoughi, Reza Rahbarghazi, Mohammad Nouri
Stem cells (SCs) have special potency to differentiate into different types of cells, especially cardiomyocytes. In order to demonstrate the therapeutic applications of these cells, various investigations are recently being developed. Cardiac progenitor cells are endogenous cardiac SCs that found to express tyrosine kinase receptors, c-Kit and other stemness features in adult heart, contributing to the regeneration of cardiac tissue after injury. This lineage is able to efficiently trans-differentiate into different cell types such as cardiomyocytes, endothelial cells, and smooth muscle cells...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/29104594/sex-differences-of-human-cardiac-progenitor-cells-in-the-biological-response-to-tnf-%C3%AE-treatment
#8
Elisabetta Straface, Lucrezia Gambardella, Francesca Pagano, Francesco Angelini, Barbara Ascione, Rosa Vona, Elena De Falco, Elena Cavarretta, Raffaele La Russa, Walter Malorni, Giacomo Frati, Isotta Chimenti
Adult cardiac progenitor cells (CPCs), isolated as cardiosphere-derived cells (CDCs), represent promising candidates for cardiac regenerative therapy. CDCs can be expanded in vitro manyfolds without losing their differentiation potential, reaching numbers that are appropriate for clinical applications. Since mechanisms of successful CDC survival and engraftment in the damaged myocardium are still critical and unresolved issues, we aimed at deciphering possible key factors capable of bolstering CDC function...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29096622/tissue-engineered-smooth-muscle-cell-and-endothelial-progenitor-cell-bi-level-cell-sheets-prevent-progression-of-cardiac-dysfunction-microvascular-dysfunction-and-interstitial-fibrosis-in-a-rodent-model-of-type-1-diabetes-induced-cardiomyopathy
#9
Masashi Kawamura, Michael J Paulsen, Andrew B Goldstone, Yasuhiro Shudo, Hanjay Wang, Amanda N Steele, Lyndsay M Stapleton, Bryan B Edwards, Anahita Eskandari, Vi N Truong, Kevin J Jaatinen, Arnar B Ingason, Shigeru Miyagawa, Yoshiki Sawa, Y Joseph Woo
BACKGROUND: Diabetes mellitus is a risk factor for coronary artery disease and diabetic cardiomyopathy, and adversely impacts outcomes following coronary artery bypass grafting. Current treatments focus on macro-revascularization and neglect the microvascular disease typical of diabetes mellitus-induced cardiomyopathy (DMCM). We hypothesized that engineered smooth muscle cell (SMC)-endothelial progenitor cell (EPC) bi-level cell sheets could improve ventricular dysfunction in DMCM. METHODS: Primary mesenchymal stem cells (MSCs) and EPCs were isolated from the bone marrow of Wistar rats, and MSCs were differentiated into SMCs by culturing on a fibronectin-coated dish...
November 2, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29094480/myocardial-infarction-does-not-affect-circulating-hematopoietic-stem-and-progenitor-cell-self-renewal-ability-in-a-rat-model
#10
J M Kröpfl, C M Spengler, A Frobert, G Ajalbert, M N Giraud
Due to the importance of peripheral blood hematopoietic stem and progenitor cells (HPCs) in post-acute regeneration after acute myocardial infarction (MI), the present study aimed to investigate count and secondary replating capacity/self-renewal ability of HPCs in peripheral blood before and two weeks after MI. In nine female Lewis inbred rats (n = 9), myocardial infarction was induced by ligation of the left coronary artery while another nine had surgery without ligation for control purposes. Myocardial infarction was confirmed by troponin I concentrations 24 h after MI...
November 2, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29093487/micrornas-promote-skeletal-muscle-differentiation-of-mesodermal-ipsc-derived-progenitors
#11
Giorgia Giacomazzi, Bryan Holvoet, Sander Trenson, Ellen Caluwé, Bojana Kravic, Hanne Grosemans, Álvaro Cortés-Calabuig, Christophe M Deroose, Danny Huylebroeck, Said Hashemolhosseini, Stefan Janssens, Elizabeth McNally, Mattia Quattrocelli, Maurilio Sampaolesi
Muscular dystrophies (MDs) are often characterized by impairment of both skeletal and cardiac muscle. Regenerative strategies for both compartments therefore constitute a therapeutic avenue. Mesodermal iPSC-derived progenitors (MiPs) can regenerate both striated muscle types simultaneously in mice. Importantly, MiP myogenic propensity is influenced by somatic lineage retention. However, it is still unknown whether human MiPs have in vivo potential. Furthermore, methods to enhance the intrinsic myogenic properties of MiPs are likely needed, given the scope and need to correct large amounts of muscle in the MDs...
November 1, 2017: Nature Communications
https://www.readbyqxmd.com/read/29080864/endothelial-progenitor-cell-biology-and-vascular-recovery-following-transradial-cardiac-catheterization
#12
Andrew Mitchell, Takeshi Fujisawa, Nicholas L Mills, Mairi Brittan, David E Newby, Nicholas L M Cruden
BACKGROUND: Transradial catheterization is associated with radial artery injury and vasomotor dysfunction and represents an accessible model of acute vascular injury in humans. We characterized vascular injury and functional recovery to understand the role of circulating endothelial progenitor cells in vascular repair. METHODS AND RESULTS: In 50 patients (aged 64±10 years, 70% male) undergoing transradial cardiac catheterization, radial artery injury was assessed by optical coherence tomography and examination of explanted vascular sheaths...
October 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29075298/cardiac-progenitor-cells-and-the-interplay-with-their-microenvironment
#13
REVIEW
Arianna Mauretti, Sergio Spaans, Noortje A M Bax, Cecilia Sahlgren, Carlijn V C Bouten
The microenvironment plays a crucial role in the behavior of stem and progenitor cells. In the heart, cardiac progenitor cells (CPCs) reside in specific niches, characterized by key components that are altered in response to a myocardial infarction. To date, there is a lack of knowledge on these niches and on the CPC interplay with the niche components. Insight into these complex interactions and into the influence of microenvironmental factors on CPCs can be used to promote the regenerative potential of these cells...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29075297/stem-and-progenitor-cells-in-human-cardiopulmonary-development-and-regeneration
#14
REVIEW
Silvana Bardelli, Marco Moccetti
Already during embryonic development, the heart and the lung are thoroughly connected organs. Their interdependence allows our survival in the terrestrial environment by coupling cardiac output and gas exchange. The knowledge on developmental processes involving stem and progenitor cells is crucial to understand the onset of human cardiopulmonary diseases. The precise identification of various adult endogenous progenitors is still incomplete. Thus, caution should be exercised on newly available stem cell-based treatments until specific mechanisms of action are disclosed...
2017: Stem Cells International
https://www.readbyqxmd.com/read/29075204/human-cardiomyocyte-progenitor-cells-in-co-culture-with-rat-cardiomyocytes-form-a-pro-arrhythmic-substrate-evidence-for-two-different-arrhythmogenic-mechanisms
#15
Nicoline W Smit, Lucia Cócera Ortega, Anna M D Végh, Veronique M F Meijborg, Anke M Smits, Mischa Klerk, Anke J M Tijsen, Hanno L Tan, Marie-José H T Goumans, Gerard J J Boink, Ruben Coronel
Background: Cardiomyocyte progenitor cells (CMPCs) are a promising cell source for regenerative cell therapy to improve cardiac function after myocardial infarction. However, it is unknown whether undifferentiated CMPCs have arrhythmogenic risks. We investigate whether undifferentiated, regionally applied, human fetal CMPCs form a pro-arrhythmic substrate in co-culture with neonatal rat ventricular myocytes (NRVMs). Method: Unipolar extracellular electrograms, derived from micro-electrode arrays (8 × 8 electrodes) containing monolayers of NRVMs (control), or co-cultures of NRVMs and locally seeded CMPCs were used to determine conduction velocity and the incidence of tachy-arrhythmias...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29074412/molecular-mechanism-of-doxorubicin-induced-cardiomyopathy-an-update
#16
REVIEW
Kaviyarasi Renu, Abilash V G, Tirupathi Pichiah P B, Sankarganesh Arunachalam
Doxorubicin is utilized for anti-neoplastic treatment for several decades. The utility of this drug is limited due to its side effects. Generally, doxorubicin toxicity is originated from the myocardium and then other organs are also ruined. The mechanism of doxorubicin is intercalated with the DNA and inhibits topoisomerase 2. There are various signalling mechanisms involved in doxorubicin cardiotoxicity. First and foremost, the doxorubicin-induced cardiotoxicity is due to oxidative stress. Cardiac mitochondrial damage is supposed after few hours following the revelation of doxorubicin...
October 23, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29066438/polo-like-kinase-2-is-dynamically-regulated-to-coordinate-proliferation-and-early-lineage-specification-downstream-of-yes-associated-protein-1-in-cardiac-progenitor-cells
#17
Michika Mochizuki, Vera Lorenz, Robert Ivanek, Giacomo Della Verde, Emanuele Gaudiello, Anna Marsano, Otmar Pfister, Gabriela M Kuster
BACKGROUND: Recent studies suggest that adult cardiac progenitor cells (CPCs) can produce new cardiac cells. Such cell formation requires an intricate coordination of progenitor cell proliferation and commitment, but the molecular cues responsible for this regulation in CPCs are ill defined. METHODS AND RESULTS: Extracellular matrix components are important instructors of cell fate. Using laminin and fibronectin, we induced two slightly distinct CPC phenotypes differing in proliferation rate and commitment status and analyzed the early transcriptomic response to CPC adhesion (<2 hours)...
October 24, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29064067/stem-cells-in-regenerative-cardiology
#18
Semih Arbatlı, Galip Servet Aslan, Fatih Kocabaş
The common prevalence of heart failure and limitations in its treatment are leading cause of attention and interest towards the induction of cardiac regeneration with novel approaches. Recent studies provide growing evidence regarding bona fide cardiac regeneration post genetic manipulations, administration of stimulatory factors and myocardial injuries in animal models and human studies. To this end, stem cells of different sources have been tested to treat heart failure for the development of cellular therapies...
October 25, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29061637/unique-developmental-trajectories-and-genetic-regulation-of-ventricular-and-outflow-tract-progenitors-in-the-zebrafish-second-heart-field
#19
Noelle Paffett-Lugassy, Natasha Novikov, Spencer Jeffrey, Maryline Abrial, Burcu Guner-Ataman, Srinivasan Sakthivel, Caroline E Burns, C Geoffrey Burns
During mammalian embryogenesis, cardiac progenitor cells constituting the second heart field (SHF) give rise to the right ventricle and primitive outflow tract (OFT), the latter of which is particularly vulnerable to developmental malformations that underlie common congenital heart defects. In zebrafish, SHF progenitors produce half of the single ventricle's myocardium and contribute significantly to the OFT. Previous lineage tracing and mutant analyses suggested that SHF ventricular and OFT progenitors co-migrate to the arterial pole of the zebrafish heart tube soon after their specification in the nkx2...
October 23, 2017: Development
https://www.readbyqxmd.com/read/29057227/getting-old-through-the-blood-circulating-molecules-in-aging-and-senescence-of-cardiovascular-regenerative-cells
#20
REVIEW
Francesco Angelini, Francesca Pagano, Antonella Bordin, Vittorio Picchio, Elena De Falco, Isotta Chimenti
Global aging is a hallmark of our century. The natural multifactorial process resulting in aging involves structural and functional changes, affecting molecules, cells, and tissues. As the western population is getting older, we are witnessing an increase in the burden of cardiovascular events, some of which are known to be directly linked to cellular senescence and dysfunction. In this review, we will focus on the description of a few circulating molecules, which have been correlated to life span, aging, and cardiovascular homeostasis...
2017: Frontiers in Cardiovascular Medicine
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