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Second heart field

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https://www.readbyqxmd.com/read/28227727/the-effect-of-data-exchange-protocols-on-decision-support-systems-for-heart-sounds
#1
P Gomes, S Faria, M Coimbra, P Gomes, S Faria, M Coimbra, P Gomes, S Faria, M Coimbra
Heart auscultation is one of the basic exams performed during a patient physical examination, but it is also one that has a high skill ceiling. Decision support systems can provide physicians with a tool that can help to reduce the demanding skill requirements of this exam. Nevertheless, this second opinion needs to be delivered in a timely interval in order to be truly useful for a physician. To do this we need not only optimized algorithms, but also a well designed system. In this paper, we have studied how two different data exchange protocols, that define how data should be transferred from an acquisition to a process module, can impact the celerity of delivering second opinion to a physician...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226689/patient-movement-compensation-for-3d-echocardiography-fusion
#2
Abhilash R Hareendranathan, Michelle Hanbidge, Allen He, Michelle Noga, Pierre Boulanger, Harald Becher, Kumaradevan Punithakumar, Abhilash R Hareendranathan, Michelle Hanbidge, Allen He, Michelle Noga, Pierre Boulanger, Harald Becher, Kumaradevan Punithakumar, Allen He, Pierre Boulanger, Harald Becher, Michelle Noga, Kumaradevan Punithakumar, Michelle Hanbidge, Abhilash R Hareendranathan
Limited field of view (FOV) is a major problem for 3D real-time echocardiography (3DRTE), which results in an incomplete representation of cardiac anatomy. Various image registration techniques have been proposed to improve the field of view in 3DRTE by fusing multiple image volumes. However, these techniques require significant overlap between the individual volumes and rely on high image resolution and high signal-to-noise ratio. Changes in the heart position due to patient movement during image acquisition can also reduce the quality of image fusion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28192943/ultrafast-chiral-chromatography-as-the-second-dimension-in-two-dimensional-liquid-chromatography-experiments
#3
Chandan L Barhate, Erik L Regalado, Nathan D Contrella, Joon Lee, Junyong Jo, Alexey A Makarov, Daniel W Armstrong, Christopher J Welch
Chromatographic separation and analysis of complex mixtures of closely related species is one of the most challenging tasks in modern pharmaceutical analysis. In recent years, two-dimensional liquid chromatography (2D-LC) has become a valuable tool for improving peak capacity and selectivity. However, the relatively slow speed of chiral separations has limited the use of chiral stationary phases (CSPs) as the second dimension in 2D-LC, especially in the comprehensive mode. Realizing that the recent revolution in the field of ultrafast enantioselective chromatography could now provide significantly faster separations, we herein report an investigation into the use of ultrafast chiral chromatography as a second dimension for 2D chromatographic separations...
January 23, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28167794/gata4-potentiates-second-heart-field-proliferation-and-hedgehog-signaling-for-cardiac-septation
#4
Lun Zhou, Jielin Liu, Menglan Xiang, Patrick Olson, Alexander Guzzetta, Ke Zhang, Ivan P Moskowitz, Linglin Xie
GATA4, an essential cardiogenic transcription factor, provides a model for dominant transcription factor mutations in human disease. Dominant GATA4 mutations cause congenital heart disease (CHD), specifically atrial and atrioventricular septal defects (ASDs and AVSDs). We found that second heart field (SHF)-specific Gata4 heterozygote embryos recapitulated the AVSDs observed in germline Gata4 heterozygote embryos. A proliferation defect of SHF atrial septum progenitors and hypoplasia of the dorsal mesenchymal protrusion, rather than anlage of the atrioventricular septum, were observed in this model...
February 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28133602/the-dorsal-mesenchymal-protrusion-and-the-pathogenesis-of-atrioventricular-septal-defects
#5
Tara Burns, Yanping Yang, Emilye Hiriart, Andy Wessels
Congenital heart malformations are the most common type of defects found at birth. About 1% of infants are born with one or more heart defect on a yearly basis. Congenital Heart Disease (CHD) causes more deaths in the first year of life than any other congenital abnormality, and each year, nearly twice as many children die in the United States from CHD as from all forms of childhood cancers combined. Atrioventricular septal defects (AVSD) are congenital heart malformations affecting approximately 1 in 2000 live births...
December 2016: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/28129151/a-method-for-measuring-orientation-within-a-magnetic-resonance-imaging-scanner-using-gravity-and-the-static-magnetic-field-vectorient
#6
Adam van Niekerk, Andre van der Kouwe, Ernesta Meintjes
In MRI brain imaging, subject motion limits obtainable image clarity. Due to the hardware layout of an MRI scanner, gradient excitations can be used to rapidly detect position. Orientation, however, is more difficult to detect and is commonly calculated by comparing the position measurements of multiple spatially constrained points to a reference dataset. The result is increased size of the apparatus the subject must wear, which can influence the imaging workflow. In optical based methods marker attachment sites are limited due to the line of sight requirement between the camera and marker, and an external reference frame is introduced...
January 25, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28122228/temporally-distinct-six2-positive-second-heart-field-progenitors-regulate-mammalian-heart-development-and-disease
#7
Zhengfang Zhou, Jingying Wang, Chaoshe Guo, Weiting Chang, Jian Zhuang, Ping Zhu, Xue Li
The embryonic process of forming a complex structure such as the heart remains poorly understood. Here, we show that Six2 marks a dynamic subset of second heart field progenitors. Six2-positive (Six2(+)) progenitors are rapidly recruited and assigned, and their descendants are allocated successively to regions of the heart from the right ventricle (RV) to the pulmonary trunk. Global ablation of Six2(+) progenitors resulted in RV hypoplasia and pulmonary atresia. An early stage-specific ablation of a small subset of Six2(+) progenitors did not cause any apparent structural defect at birth but rather resulted in adult-onset cardiac hypertrophy and dysfunction...
January 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/28106108/isl2b-regulates-anterior-second-heart-field-development-in-zebrafish
#8
Hagen R Witzel, Sirisha Cheedipudi, Rui Gao, Didier Y R Stainier, Gergana D Dobreva
After initial formation, the heart tube grows by addition of second heart field progenitor cells to its poles. The transcription factor Isl1 is expressed in the entire second heart field in mouse, and Isl1-deficient mouse embryos show defects in arterial and venous pole development. The expression of Isl1 is conserved in zebrafish cardiac progenitors; however, Isl1 is required for cardiomyocyte differentiation only at the venous pole. Here we show that Isl1 homologues are expressed in specific patterns in the developing zebrafish heart and play distinct roles during cardiac morphogenesis...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28087459/wnt-signaling-balances-specification-of-the-cardiac-and-pharyngeal-muscle-fields
#9
Amrita Mandal, Andrew Holowiecki, Yuntao Charlie Song, Joshua S Waxman
Canonical Wnt/β-catenin (Wnt) signaling plays multiple conserved roles during fate specification of cardiac progenitors in developing vertebrate embryos. Although lineage analysis in ascidians and mice has indicated there is a close relationship between the cardiac second heart field (SHF) and pharyngeal muscle (PM) progenitors, the signals underlying directional fate decisions of the cells within the cardio-pharyngeal muscle field in vertebrates are not yet understood. Here, we examined the temporal requirements of Wnt signaling in cardiac and PM development...
January 10, 2017: Mechanisms of Development
https://www.readbyqxmd.com/read/28048814/su-f-j-123-ct-based-determination-of-dibh-variability-and-its-dosimetric-impact-on-post-mastectomy-plus-regional-nodal-radiation-therapy
#10
M Malin, H Kang, K Tatebe, Y Hasan, S Chmura, H Al-Hallaq
PURPOSE: Breast cancer radiotherapy delivered using voluntary deep inspiration breath-hold (DIBH) requires reproducible breath holds, particularly when matching supraclavicular fields to tangential fields. We studied the impact of variation in DIBHs on CTV and OAR dose metrics by comparing the dose distribution computed on two DIBH CT scans taken at the time of simulation. METHODS: Ten patients receiving 50Gy in 25 fractions to the left chestwall and regional lymph nodes were studied...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28033319/correction-foxf-genes-integrate-tbx5-and-hedgehog-pathways-in-the-second-heart-field-for-cardiac-septation
#11
Andrew D Hoffmann, Xinan Holly Yang, Ozanna Burnicka-Turek, Joshua D Bosman, Xiaomeng Ren, Linglin Xie, Jeffrey D Steimle, Steven A Vokes, Andrew P McMahon, Vladimir V Kalinichenko, Ivan P Moskowitz
[This corrects the article DOI: 10.1371/journal.pgen.1004604.].
December 2016: PLoS Genetics
https://www.readbyqxmd.com/read/28032100/high-insecticides-resistance-in-culex-pipiens-diptera-culicidae-from-tehran-capital-of-iran
#12
Yaser Salim-Abadi, Mohammad Ali Oshaghi, Ahmad Ali Enayati, Mohammad Reza Abai, Hassan Vatandoost, Mohammad Reza Eshraghian, Hossein Mirhendi, Ahmad Ali Hanafi-Bojd, Mohammad Amin Gorouhi, Fatemeh Rafi
BACKGROUND: During recent years transmission of Dirofilaria immitis (dog heart worm) by Culex pipiens and West Nile virus have been reported from Iran. The present study was preformed for evaluating the susceptibility status of Cx. pipiens collected from capital city of Tehran, Iran. METHODS: Four Insecticides including: DDT 4%, Lambdacyhalothrin 0.05%, Deltamethrin 0.05% and Cyfluthrin 0.15 % according to WHO standard methods were used for evaluating the susceptibility status of Cx...
December 2016: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/28026746/robust-estimation-of-sparse-narrowband-spectra-from-binary-neuronal-spiking-data
#13
Sina Miran, Patrick Purdon, Emery Brown, Behtash Babadi
OBJECTIVE: Characterizing the spectral properties of neuronal responses is an important problem in computational neuroscience, as it provides insight into the spectral organization of the underlying functional neural processes. Although spectral analysis techniques are widely used in the analysis of noninvasive neural recordings such as EEG, their application to spiking data is limited due to the binary and non-linear nature of neuronal spiking. In this paper, we address the problem of estimating the power spectral density of the neural covariate driving the spiking statistics of a neuronal population from binary observations...
December 22, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28004586/psycho-ophthalmology-contributions-of-health-psychology-to-the-assessment-and-treatment-of-glaucoma
#14
Jorge Luis Méndez-Ulrich, Antoni Sanz
BACKGROUND: Asymptomatic in its early stages, glaucoma is the second leading cause of blindness worldwide. While psychosocial factors are taken into consideration for a host of diseases such as cancer, heart disease and autoimmune conditions, to date, psychological issues have been ignored in the clinical management of glaucoma. OBJECTIVE: This work reviews the most relevant contributions from a health psychology perspective for the assessment and treatment of glaucoma, which is emerging in the field of psycho-ophthalmology...
December 22, 2016: Psychology & Health
https://www.readbyqxmd.com/read/28003175/design-of-a-serious-game-for-handling-obstetrical-emergencies
#15
Estelle Jean Dit Gautier, Virginie Bot-Robin, Aurélien Libessart, Guillaume Doucède, Michel Cosson, Chrystèle Rubod
BACKGROUND: The emergence of new technologies in the obstetrical field should lead to the development of learning applications, specifically for obstetrical emergencies. Many childbirth simulations have been recently developed. However, to date none of them have been integrated into a serious game. OBJECTIVE: Our objective was to design a new type of immersive serious game, using virtual glasses to facilitate the learning of pregnancy and childbirth pathologies...
December 21, 2016: JMIR Serious Games
https://www.readbyqxmd.com/read/27989237/modernising-epidemic-science-enabling-patient-centred-research-during-epidemics
#16
EDITORIAL
Amanda M Rojek, Peter W Horby
BACKGROUND: Emerging and epidemic infectious disease outbreaks are a significant public health problem and global health security threat. As an outbreak begins, epidemiological investigations and traditional public health responses are generally mounted very quickly. However, patient-centred research is usually not prioritised when planning and enacting the response. Instead, the clinical research response occurs subsequent to and separate from the public health response, and is inadequate for evidence-based decision-making at the bedside or in the offices of public health policymakers...
December 19, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27955943/endothelium-in-the-pharyngeal-arches-3-4-and-6-is-derived-from-the-second-heart-field
#17
Xia Wang, Dongying Chen, Kelley Chen, Ali Jubran, AnnJosette Ramirez, Sophie Astrof
Oxygenated blood from the heart is directed into the systemic circulation through the aortic arch arteries (AAAs). The AAAs arise by remodeling of three symmetrical pairs of pharyngeal arch arteries (PAAs), which connect the heart with the paired dorsal aortae at mid-gestation. Aberrant PAA formation results in defects frequently observed in patients with lethal congenital heart disease. How the PAAs form in mammals is not understood. The work presented in this manuscript shows that the second heart field (SHF) is the major source of progenitors giving rise to the endothelium of the pharyngeal arches 3 - 6, while the endothelium in the pharyngeal arches 1 and 2 is derived from a different source...
January 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/27918914/transformation-of-jaw-muscle-satellite-cells-to-cardiomyocytes
#18
Randall S Daughters, Susan A Keirstead, Jonathan M W Slack
In the embryo a population of progenitor cells known as the second heart field forms not just parts of the heart but also the jaw muscles of the head. Here we show that it is possible to take skeletal muscle satellite cells from jaw muscles of the adult mouse and to direct their differentiation to become heart muscle cells (cardiomyocytes). This is done by exposing the cells to extracellular factors similar to those which heart progenitors would experience during normal embryonic development. By contrast, cardiac differentiation does not occur at all from satellite cells isolated from trunk and limb muscles, which originate from the somites of the embryo...
January 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/27893754/cyp26-enzymes-facilitate-second-heart-field-progenitor-addition-and-maintenance-of-ventricular-integrity
#19
Ariel B Rydeen, Joshua S Waxman
Although retinoic acid (RA) teratogenicity has been investigated for decades, the mechanisms underlying RA-induced outflow tract (OFT) malformations are not understood. Here, we show zebrafish embryos deficient for Cyp26a1 and Cyp26c1 enzymes, which promote RA degradation, have OFT defects resulting from two mechanisms: first, a failure of second heart field (SHF) progenitors to join the OFT, instead contributing to the pharyngeal arch arteries (PAAs), and second, a loss of first heart field (FHF) ventricular cardiomyocytes due to disrupted cell polarity and extrusion from the heart tube...
November 2016: PLoS Biology
https://www.readbyqxmd.com/read/27890346/the-uk-heartspare-study-stage-ii-multicentre-evaluation-of-a-voluntary-breath-hold-technique-in-patients-receiving-breast-radiotherapy
#20
F R Bartlett, E M Donovan, H A McNair, L A Corsini, R M Colgan, P M Evans, L Maynard, C Griffin, J S Haviland, J R Yarnold, A M Kirby
AIMS: To evaluate the feasibility and heart-sparing ability of the voluntary breath-hold (VBH) technique in a multicentre setting. MATERIALS AND METHODS: Patients were recruited from 10 UK centres. Following surgery for early left breast cancer, patients with any heart inside the 50% isodose from a standard free-breathing tangential field treatment plan underwent a second planning computed tomography (CT) scan using the VBH technique. A separate treatment plan was prepared on the VBH CT scan and used for treatment...
November 24, 2016: Clinical Oncology: a Journal of the Royal College of Radiologists
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