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https://www.readbyqxmd.com/read/28430109/acquisition-of-electrocardiogram-signals-during-magnetic-resonance-imaging
#1
Julien Oster, Gari Clifford
The recording of the electrocardiogram (ECG) during Magnetic Resonance Imaging (MRI) acquisition is of great interest and importance. Firstly, MRI acquisition is a relatively slow process, which therefore complicates the imaging of moving organs. Cardiac MRI requires the development of strategies for acquiring high quality images, which is mainly achieved by synchronising the image acquisition with a specific time during the cardiac cycle. The ECG is used to monitor the heart's activity, and the detection of the largest and steepest peak in the cardiac cycle (the QRS complex) triggers the acquisition of slices of the k-space...
April 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28388767/treatment-of-coronary-artery-disease-randomized-trials-on-myocardial-revascularization-and-complete-arterial-bypass-grafting
#2
Ardawan J Rastan
Friedrich Wilhelm Mohr from the very beginning of his career as a cardiac surgeon was involved in the refinements of coronary artery bypass grafting (CABG). At the Leipzig Heart Center, his spirit of early adapting to new technologies inspired the entire team and led to a matchless scientific atmosphere to find solutions to improve almost all fields of cardiac surgery, including CABG. In combination with a tremendous number of patients with indications for isolated coronary artery bypass Prof. Mohr as the surgical principle investigator and the Leipzig Heart Center were able to include patients in the Synergy between PCI [percutaneous coronary intervention] with Taxus and Cardiac Surgery (SYNTAX) trial, the first randomized trials comparing CABG and PCIs using the drug-eluting stents...
April 2017: Thoracic and Cardiovascular Surgeon
https://www.readbyqxmd.com/read/28388274/six-minute-stepper-test-to-set-pulmonary-rehabilitation-intensity-in-patients-with-copd-a-retrospective-study
#3
Tristan Bonnevie, Francis-Edouard Gravier, Marie Leboullenger, Clément Médrinal, Catherine Viacroze, Antoine Cuvelier, Jean-François Muir, Catherine Tardif, David Debeaumont
Pulmonary rehabilitation (PR) improves outcomes in patients with chronic obstructive pulmonary disease (COPD). Optimal assessment includes cardiopulmonary exercise testing (CPET), but consultations are limited. Field tests could be used to individualize PR instead of CPET. The six-minute stepper test (6MST) is easy to set up and its sensitivity and reproducibility have previously been reported in patients with COPD. The aim of this study was to develop a prediction equation to set intensity in patients attending PR, based on the 6MST...
April 7, 2017: COPD
https://www.readbyqxmd.com/read/28370288/a-core-avenue-for-transcultural-research-on-dementia-on-the-cross-linguistic-generalization-of-language-related-effects-in-alzheimer-s-disease-and-parkinson-s-disease
#4
Noelia Calvo, Agustín Ibáñez, Edinson Muñoz, Adolfo M García
OBJECTIVE: Language is a key source of cross-cultural variability, which may have both subtle and major effects on neurocognition. However, this issue has been largely overlooked in two flourishing lines of research assessing the relationship between language-related neural systems and dementia. This paper assesses the limitations of the evidence on (i) the neuroprotective effects of bilingualism in Alzheimer's disease and (ii) specific language deficits as markers of Parkinson's disease...
March 28, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28369938/40-mhz-high-frequency-ultrafast-ultrasound-imaging
#5
Chih-Chung Huang, Pei-Yu Chen, Po-Hsun Peng, Po-Yang Lee
PURPOSE: Ultrafast high-frame-rate ultrasound imaging based on coherent-plane-wave compounding has been developed for many biomedical applications. Most coherent-plane-wave compounding systems typically operate at 3-15 MHz, and the image resolution for this frequency range is not sufficient for visualizing microstructure tissues. Therefore, the purpose of this study was to implement a high-frequency ultrafast ultrasound imaging operating at 40 MHz. METHODS: The plane-wave compounding imaging and conventional multifocus B-mode imaging were performed using the Field II toolbox of MATLAB in simulation study...
March 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28357999/epithelial-tension-in-the-second-heart-field-promotes-mouse-heart-tube-elongation
#6
Alexandre Francou, Christopher De Bono, Robert G Kelly
Extension of the vertebrate heart tube is driven by progressive addition of second heart field (SHF) progenitor cells to the poles of the heart. Defects in this process cause a spectrum of congenital anomalies. SHF cells form an epithelial layer in splanchnic mesoderm in the dorsal wall of the pericardial cavity. Here we report oriented cell elongation, polarized actomyosin distribution and nuclear YAP/TAZ in a proliferative centre in the posterior dorsal pericardial wall during heart tube extension. These parameters are indicative of mechanical stress, further supported by analysis of cell shape changes in wound assays...
March 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/28314213/primary-intracardiac-leiomyoma-arising-from-cardiomyocyte-progenitors-at-the-right-ventriculoseptal-interface-case-report-with-literature-review
#7
Kavita Gaur, Kaushik Majumdar, Navnita Kisku, Ranjana Gondal, Puja Sakhuja, Deepak Kumar Satsangi
Primary cardiac neoplasms are rare and are usually benign myxomas and rhabdomyomas. Cardiac leiomyomas are usually seen as a part of the spectrum of intravenous leiomyomatosis or benign metastasizing leiomyoma. De novo occurrence of primary intracardiac leiomyomas (PICL) is a rarity. Herein we describe a 14-year-old boy presenting with intermittent dyspnea for 2 years, with a large right ventricular mass suggestive of myxoma on transthoracic echocardiography, without any extracardiac lesions. Histology and immunohistochemistry of the tumor excised under cardiopulmonary bypass confirmed a PICL arising at the cardiomyocyte-smooth muscle septal interface...
March 9, 2017: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/28269476/the-effect-of-data-exchange-protocols-on-decision-support-systems-for-heart-sounds
#8
P Gomes, S Faria, M Coimbra
Heart auscultation is one of the basic exams performed during a patient physical examination, but it is also one that has a high skill ceiling. Decision support systems can provide physicians with a tool that can help to reduce the demanding skill requirements of this exam. Nevertheless, this second opinion needs to be delivered in a timely interval in order to be truly useful for a physician. To do this we need not only optimized algorithms, but also a well designed system. In this paper, we have studied how two different data exchange protocols, that define how data should be transferred from an acquisition to a process module, can impact the celerity of delivering second opinion to a physician...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268515/patient-movement-compensation-for-3d-echocardiography-fusion
#9
Abhilash R Hareendranathan, Michelle Hanbidge, Allen He, Michelle Noga, Pierre Boulanger, Harald Becher, Kumaradevan Punithakumar
Limited field of view (FOV) is a major problem for 3D real-time echocardiography (3DRTE), which results in an incomplete representation of cardiac anatomy. Various image registration techniques have been proposed to improve the field of view in 3DRTE by fusing multiple image volumes. However, these techniques require significant overlap between the individual volumes and rely on high image resolution and high signal-to-noise ratio. Changes in the heart position due to patient movement during image acquisition can also reduce the quality of image fusion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28259460/heart-cutting-two-dimensional-gas-chromatography-isotope-ratio-mass-spectrometry-analysis-of-monoaromatic-hydrocarbons-in-complex-groundwater-and-gas-phase-samples
#10
Violaine Ponsin, Timothy E Buscheck, Daniel Hunkeler
Compound-specific isotope analysis (CSIA) is increasingly used to evaluate the origin and fate of petroleum hydrocarbons in the environment. However, as samples often contain a complex mixture of compounds and the method requires a full chromatographic separation, it can be challenging to obtain accurate and precise isotope values. In this study, in order to develop a method to analyze carbon isotopes in benzene, toluene, ethylbenzene, and xylenes (BTEX) in complex environmental samples, a two-dimensional heart-cutting gas chromatograph (GC) was hyphenated to an isotope ratio mass spectrometer (IRMS)...
April 7, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28243206/spo2-and-heart-rate-during-a-real-hike-at-altitude-are-significantly-different-than-at-its-simulation-in-normobaric-hypoxia
#11
Nikolaus C Netzer, Linda Rausch, Arn H Eliasson, Hannes Gatterer, Matthias Friess, Martin Burtscher, Stephan Pramsohler
Rationale: Exposures to simulated altitude (normobaric hypoxia, NH) are frequently used in preparation for mountaineering activities at real altitude (hypobaric hypoxia, HH). However, physiological responses to exercise in NH and HH may differ. Unfortunately clinically useful information on such differences is largely lacking. This study therefore compared exercise responses between a simulated hike on a treadmill in NH and a similar field hike in HH. Methods: Six subjects (four men) participated in two trials, one in a NH chamber and a second in HH at an altitude of 4,205 m on the mountain Mauna Kea...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28227727/the-effect-of-data-exchange-protocols-on-decision-support-systems-for-heart-sounds
#12
P Gomes, S Faria, M Coimbra, P Gomes, S Faria, M Coimbra, P Gomes, S Faria, M Coimbra
Heart auscultation is one of the basic exams performed during a patient physical examination, but it is also one that has a high skill ceiling. Decision support systems can provide physicians with a tool that can help to reduce the demanding skill requirements of this exam. Nevertheless, this second opinion needs to be delivered in a timely interval in order to be truly useful for a physician. To do this we need not only optimized algorithms, but also a well designed system. In this paper, we have studied how two different data exchange protocols, that define how data should be transferred from an acquisition to a process module, can impact the celerity of delivering second opinion to a physician...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226689/patient-movement-compensation-for-3d-echocardiography-fusion
#13
Abhilash R Hareendranathan, Michelle Hanbidge, Allen He, Michelle Noga, Pierre Boulanger, Harald Becher, Kumaradevan Punithakumar, Abhilash R Hareendranathan, Michelle Hanbidge, Allen He, Michelle Noga, Pierre Boulanger, Harald Becher, Kumaradevan Punithakumar, Allen He, Pierre Boulanger, Harald Becher, Michelle Noga, Kumaradevan Punithakumar, Michelle Hanbidge, Abhilash R Hareendranathan
Limited field of view (FOV) is a major problem for 3D real-time echocardiography (3DRTE), which results in an incomplete representation of cardiac anatomy. Various image registration techniques have been proposed to improve the field of view in 3DRTE by fusing multiple image volumes. However, these techniques require significant overlap between the individual volumes and rely on high image resolution and high signal-to-noise ratio. Changes in the heart position due to patient movement during image acquisition can also reduce the quality of image fusion...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28192943/ultrafast-chiral-chromatography-as-the-second-dimension-in-two-dimensional-liquid-chromatography-experiments
#14
Chandan L Barhate, Erik L Regalado, Nathan D Contrella, Joon Lee, Junyong Jo, Alexey A Makarov, Daniel W Armstrong, Christopher J Welch
Chromatographic separation and analysis of complex mixtures of closely related species is one of the most challenging tasks in modern pharmaceutical analysis. In recent years, two-dimensional liquid chromatography (2D-LC) has become a valuable tool for improving peak capacity and selectivity. However, the relatively slow speed of chiral separations has limited the use of chiral stationary phases (CSPs) as the second dimension in 2D-LC, especially in the comprehensive mode. Realizing that the recent revolution in the field of ultrafast enantioselective chromatography could now provide significantly faster separations, we herein report an investigation into the use of ultrafast chiral chromatography as a second dimension for 2D chromatographic separations...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28167794/gata4-potentiates-second-heart-field-proliferation-and-hedgehog-signaling-for-cardiac-septation
#15
Lun Zhou, Jielin Liu, Menglan Xiang, Patrick Olson, Alexander Guzzetta, Ke Zhang, Ivan P Moskowitz, Linglin Xie
GATA4, an essential cardiogenic transcription factor, provides a model for dominant transcription factor mutations in human disease. Dominant GATA4 mutations cause congenital heart disease (CHD), specifically atrial and atrioventricular septal defects (ASDs and AVSDs). We found that second heart field (SHF)-specific Gata4 heterozygote embryos recapitulated the AVSDs observed in germline Gata4 heterozygote embryos. A proliferation defect of SHF atrial septum progenitors and hypoplasia of the dorsal mesenchymal protrusion, rather than anlage of the atrioventricular septum, were observed in this model...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28133602/the-dorsal-mesenchymal-protrusion-and-the-pathogenesis-of-atrioventricular-septal-defects
#16
Tara Burns, Yanping Yang, Emilye Hiriart, Andy Wessels
Congenital heart malformations are the most common type of defects found at birth. About 1% of infants are born with one or more heart defect on a yearly basis. Congenital Heart Disease (CHD) causes more deaths in the first year of life than any other congenital abnormality, and each year, nearly twice as many children die in the United States from CHD as from all forms of childhood cancers combined. Atrioventricular septal defects (AVSD) are congenital heart malformations affecting approximately 1 in 2000 live births...
December 2016: Journal of Cardiovascular Development and Disease
https://www.readbyqxmd.com/read/28129151/a-method-for-measuring-orientation-within-a-magnetic-resonance-imaging-scanner-using-gravity-and-the-static-magnetic-field-vectorient
#17
Adam van Niekerk, Andre van der Kouwe, Ernesta Meintjes
In MRI brain imaging, subject motion limits obtainable image clarity. Due to the hardware layout of an MRI scanner, gradient excitations can be used to rapidly detect position. Orientation, however, is more difficult to detect and is commonly calculated by comparing the position measurements of multiple spatially constrained points to a reference dataset. The result is increased size of the apparatus the subject must wear, which can influence the imaging workflow. In optical based methods marker attachment sites are limited due to the line of sight requirement between the camera and marker, and an external reference frame is introduced...
January 25, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28122228/temporally-distinct-six2-positive-second-heart-field-progenitors-regulate-mammalian-heart-development-and-disease
#18
Zhengfang Zhou, Jingying Wang, Chaoshe Guo, Weiting Chang, Jian Zhuang, Ping Zhu, Xue Li
The embryonic process of forming a complex structure such as the heart remains poorly understood. Here, we show that Six2 marks a dynamic subset of second heart field progenitors. Six2-positive (Six2(+)) progenitors are rapidly recruited and assigned, and their descendants are allocated successively to regions of the heart from the right ventricle (RV) to the pulmonary trunk. Global ablation of Six2(+) progenitors resulted in RV hypoplasia and pulmonary atresia. An early stage-specific ablation of a small subset of Six2(+) progenitors did not cause any apparent structural defect at birth but rather resulted in adult-onset cardiac hypertrophy and dysfunction...
January 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/28106108/isl2b-regulates-anterior-second-heart-field-development-in-zebrafish
#19
Hagen R Witzel, Sirisha Cheedipudi, Rui Gao, Didier Y R Stainier, Gergana D Dobreva
After initial formation, the heart tube grows by addition of second heart field progenitor cells to its poles. The transcription factor Isl1 is expressed in the entire second heart field in mouse, and Isl1-deficient mouse embryos show defects in arterial and venous pole development. The expression of Isl1 is conserved in zebrafish cardiac progenitors; however, Isl1 is required for cardiomyocyte differentiation only at the venous pole. Here we show that Isl1 homologues are expressed in specific patterns in the developing zebrafish heart and play distinct roles during cardiac morphogenesis...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28087459/wnt-signaling-balances-specification-of-the-cardiac-and-pharyngeal-muscle-fields
#20
Amrita Mandal, Andrew Holowiecki, Yuntao Charlie Song, Joshua S Waxman
Canonical Wnt/β-catenin (Wnt) signaling plays multiple conserved roles during fate specification of cardiac progenitors in developing vertebrate embryos. Although lineage analysis in ascidians and mice has indicated there is a close relationship between the cardiac second heart field (SHF) and pharyngeal muscle (PM) progenitors, the signals underlying directional fate decisions of the cells within the cardio-pharyngeal muscle field in vertebrates are not yet understood. Here, we examined the temporal requirements of Wnt signaling in cardiac and PM development...
February 2017: Mechanisms of Development
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