Elisabeth Asmus, David M Barber, Guido Bojack, Birgit Bollenbach-Wahl, Ronald W Brown, Uwe Döller, Jörg Freigang, Elmar Gatzweiler, Rahel Getachew, Ines Heinemann, Sabine Hohmann, Kwang-Yoon Ko, Bernd Laber, Gudrun Lange, Rebecca L Mattison, Klemens Minn, Thomas Müller, Thomas Petry, Anna M Reingruber, Dirk Schmutzler, Andrea Svejda, Jens Frackenpohl
BACKGROUND: There are various methods to control weeds, that represent considerable challenges for farmers around the globe, although applying small molecular compounds is still the most effective and versatile technology to date. In the search for novel chemical entities with new modes of action that can control weeds displaying resistance we have investigated two spirocyclic classes of acyl-ACP thioesterase inhibitors based on X-ray co-crystal structures and subsequent modelling studies...
February 9, 2024: Pest Management Science