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Blood stream infection

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https://www.readbyqxmd.com/read/29035441/eubacterium-moniliforme-bacteremia-in-a-woman-with-fractures
#1
Yuying Liang, Xiuyun Yin, Jianmin Xu, Shuiping Chen
E. moniliforme infections in humans have not been reported previously. We firstly described blood-stream infections caused by E. moniliforme in an elder woman with fractures of her left thigh. This study highlights the strategies to detect this anaerobic pathogen and the importance of investigating its molecular epidemiology in humans.
October 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29026161/in-vivo-noninvasive-microscopy-of-human-leucocytes
#2
Matan M Winer, Adel Zeidan, Daniella Yeheskely-Hayon, Lior Golan, Limor Minai, Eldad J Dann, Dvir Yelin
Leucocytes play a key role in our immune system, protecting the body against infections using a wide range of biological mechanisms. Effective imaging and identification of leucocytes within the blood stream in patients is challenging, however, because of their low volume fraction in the blood, the high tissue scattering and the rapid blood flow. Spectrally encoded flow cytometry (SEFC) has recently been demonstrated effective for label-free high-resolution in vivo imaging of blood cells using an optical probe that does not require mechanical scanning...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29023454/antifungal-defense-of-probiotic-lactobacillus-rhamnosus-gg-is-mediated-by-blocking-adhesion-and-nutrient-depletion
#3
Daniela Mailänder-Sánchez, Christina Braunsdorf, Christian Grumaz, Christoph Müller, Stefan Lorenz, Philip Stevens, Jeanette Wagener, Betty Hebecker, Bernhard Hube, Franz Bracher, Kai Sohn, Martin Schaller
Candida albicans is an inhabitant of mucosal surfaces in healthy individuals but also the most common cause of fungal nosocomial blood stream infections, associated with high morbidity and mortality. As such life-threatening infections often disseminate from superficial mucosal infections we aimed to study the use of probiotic Lactobacillus rhamnosus GG (LGG) in prevention of mucosal C. albicans infections. Here, we demonstrate that LGG protects oral epithelial tissue from damage caused by C. albicans in our in vitro model of oral candidiasis...
2017: PloS One
https://www.readbyqxmd.com/read/28987552/is-infection-an-independent-risk-factor-for-venous-thromboembolism-a-population-based-case-control-study
#4
Kevin P Cohoon, Aneel A Ashrani, Daniel J Crusan, Tanya M Petterson, Kent R Bailey, John A Heit
BACKGROUND: The independent association of recent infection with venous thromboembolism is uncertain. The purpose of the study was to test both overall infection (site unspecified) and specific infection sites as potential risk factors for deep vein thrombosis and pulmonary embolism adjusting for other known venous thromboembolism factors. METHODS: Using Rochester Epidemiology Project (REP) resources, we identified all Olmsted County, MN residents with objectively-diagnosed incident deep vein thrombosis or pulmonary embolism over the 13-year period, 1988-2000 (cases; n=1303), and 1-2 residents without venous thromboembolism matched to each case on age, sex and incident venous thromboembolism date (controls; n=1494)...
October 4, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28965794/health-care-associated-infections-in-pre-transplant-liver-intensive-care-unit-perspectives-and-challenges
#5
Elham A Hassan, Nahla M Elsherbiny, Abeer S Abd El-Rehim, Asmaa M A Soliman, Asmaa O Ahmed
BACKGROUND: Health care-associated infections (HAIs) threaten patient's safety worldwide especially in the intensive care units (ICU). In end-stage liver disease (ESLD), the condition is much more complicated. Data regarding HAIs among ESLD patients is lacking. We aimed to assess the incidence of HAIs, risk factors, causative micro-organisms, antimicrobial susceptibilities and mortality rates among patients with end-stage liver disease (ESLD) admitted to pre-transplant liver intensive care unit (LICU)...
September 28, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28943532/relationship-between-bacteremia-and-hemorrhagic-stroke-in-patients-with-continuous-flow-left-ventricular-assist-device
#6
Daisuke Yoshioka, Ryoto Sakaniwa, Koichi Toda, Takaaki Samura, Shunsuke Saito, Noriyuki Kashiyama, Shuhei Okazaki, Keitaro Domae, Yasushi Yoshikawa, Shigeru Miyagawa, Hiroyasu Iso, Yasushi Sakata, Yoshiki Sawa
BACKGROUND: Blood stream infection is thought to increase the risk of hemorrhagic stroke, a major adverse event with devastating outcome, in patients with continuous-flow left ventricular assist devices (LVADs). We analyzed the risk factors of hemorrhagic stroke in LVAD patients, as well as the time relationship between systemic bacteremia and hemorrhagic stroke.Methods and Results:We evaluated the incidence of systemic bacteremia and stroke in 164 patients who underwent continuous-flow LVAD implantation between 2005 and 2016...
September 23, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28939316/controlling-a-possible-outbreak-of-candida-auris-infection-lessons-learnt-from-multiple-interventions
#7
Manisha Biswal, Shivaprakash M Rudramurthy, Neha Jain, A S Shamanth, Dipti Sharma, Kajal Jain, L N Yaddanapudi, A Chakrabarti
BACKGROUND: Multi-drug-resistant Candida auris infection has been reported from five continents in recent years. The prevalence of C. auris invasive infection has been estimated at 5.3% for intensive care acquired candidaemia, in India. The transmission of the organism between the patients and from environment to patients is rapid. AIM: To understand the intra-hospital dynamics of C. auris transmission and determine the possible interventions to prevent its spread...
September 19, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28936879/parenteral-therapy-and-complications-in-patients-with-intestinal-failure-in-a-regional-unit
#8
Ruben Lorentsen, Lars Kristian Munck, Signe Wildt
OBJECTIVE: To describe a cohort of patients with intestinal failure (IF) and tunnelled catheters in a regional IF unit, treatment and catheter-related complication rates, and to compare the quality of care with previously published results from specialised IF centres in Denmark. METHODS: A retrospective chart review of an adult IF patient cohort receiving parenteral therapy through tunnelled catheters in a regional IF unit from 2005 to 2014. Demographics, indication, type and frequency of parenteral therapy, dwell time, cause of removal and complications were recorded...
September 22, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28930571/role-of-pericytes-in-vascular-immunosurveillance
#9
Konstantin Stark, Kami Pekayvaz, Steffen Massberg
Pericytes build together with endothelial cells the microvascular vessel wall. They have been mainly implicated in angiogenesis and maintenance of the blood brain barrier, but there is accumulating evidence for an immunological function of pericytes. Occupying a strategic position between the blood stream and the interstitial space, pericytes are able to sense environmental cues from both sides in an organ-specific manner and serve as gatekeepers for innate immune cells. In addition, pericytes are able to interact with leukocytes mediated by adhesion molecules as well as chemokines and are involved from the development of leukocytes in the bone marrow to their migration to injured or infected areas in target tissues...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929959/-in-vitro-effect-of-vancomycin-and-daptomycin-on-biofilm-formation-of-coagulase-negative-staphylococci-strains
#10
Duygu Nilüfer Öcal, İştar Dolapçı, Zeynep Gençtürk, Alper Tekeli
Coagulase-negative staphylococci (CNS) are one of the primer agents of blood stream infections (BSI) and catheter-related bloodstream infections (CR-BSI) which are associated mostly with the usage of central venous catheters and, important causes of morbidity and mortality despite the usage of antibacterial and supportive treatment. It is important to determine the properties of these causative microorganisms in order to make appropriate treatment of such infections. The aims of our study were to evaluate the biofilm formation of coagulase negative staphylococci (CNS) which were causative agents of bloodstream (BSI) and catheter related bloodstream infections (CR-BSI), to determine the minimum inhibitory concentration (MIC) of planktonic forms and minimal biofilm eradication concentration (MBEC) of sessile forms for vancomycin and daptomycin and to evaluate the efficacy of these antibiotics in infections with biofilm-forming isolates in vitro...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28927452/vancomycin-heteroresistance-in-coagulase-negative-staphylococcus-blood-stream-infections-from-patients-of-intensive-care-units-in-mansoura-university-hospitals-egypt
#11
Ghada El-Saeed Mashaly, Rasha Hassan El-Mahdy
BACKGROUND: Vancomycin heteroresistance in coagulase negative Staphylococci (CoNS) is a recent health concern especially in serious infections like bloodstream infections as it may lead to failure of therapy. Little information is available about the prevalence vancomycin heteroresistance in CoNS causing bloodstream infections in intensive care units (ICUs) patients of Mansoura University Hospitals (MUHs). METHODS: This prospective study enrolled 743 blood samples collected from ICUs patients presented with clinical manifestations of bloodstream infections over the period extending from January 2014 to March 2016...
September 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28924140/linoleic-and-palmitoleic-acid-block-streptokinase-mediated-plasminogen-activation-and-reduce-severity-of-invasive-group-a-streptococcal-infection
#12
Katharina Rox, Rolf Jansen, Torsten G Loof, Christine M Gillen, Steffen Bernecker, Mark J Walker, Gursharan Singh Chhatwal, Rolf Müller
In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this case antibiotics do not provide an effective cure as the bacteria are capable to hide from them very quickly. Therefore, new remedies are urgently needed. Starting from a myxobacterial natural products screening campaign, we identified two fatty acids isolated from myxobacteria, linoleic and palmitoleic acid, specifically blocking streptokinase-mediated activation of plasminogen and thereby preventing streptococci from hijacking the host's plasminogen/plasmin system...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28921804/early-blood-stream-infection-following-allogeneic-hematopoietic-stem-cell-transplantation-is-a-risk-factor-for-acute-grade-iii-iv-gvhd-in-children-and-adolescents
#13
Hirozumi Sano, Joseph A Hilinski, Muna Qayed, Kristy Applegate, Joanna G Newton, Benjamin Watkins, Kuang-Yueh Chiang, John Horan
BACKGROUND: Graft-versus-host disease (GVHD) remains a major cause of mortality and morbidity in allogeneic hematopoietic stem cell transplantation (HSCT). In adults, early blood stream infection (BSI) and acute GVHD (AGVHD) have been reported to be related. The impact of BSI on risk for AGVHD, however, has not been assessed in pediatric patients. PROCEDURE: We conducted a retrospective analysis to test the hypothesis that early BSI (before day +30) predisposes allogeneic pediatric transplant patients to severe AGVHD...
September 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28919353/presepsin-a-new-marker-of-catheter-related-blood-stream-infections-in-pediatric-patients
#14
Sevgen Tanır Basaranoglu, Eda Karadag-Oncel, Kubra Aykac, Yasemin Ozsurekci, Ahmet Emre Aycan, Ali Bulent Cengiz, Ates Kara, Mehmet Ceyhan
BACKGROUND: Catheter related blood stream infections (CRBSI) are mostly preventable hospital-acquired conditions. We aimed to investigate the value of presepsin in detection of CRBSI in hospitalized children. METHODS: Hospitalized pediatric patients who had clinical suspicion of CRBSI were followed. Results of peripheral blood cultures and blood cultures from central venous catheters, procalcitonin (PCT), C-reactive protein (CRP), total white blood cell (WBC) counts were recorded...
September 14, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28904808/intracardiac-fistula-an-unusual-complication-of-catheter-related-blood-stream-infection
#15
Abhilash Koratala, Hussain Aboud, Robert Gibson, Karen K Hamilton
In end stage renal disease patients on dialysis, the use of catheter as a vascular access is associated with a significant risk of sepsis compared to an arterio-venous fistula. Our case emphasizes the importance of having high index of suspicion for unusual complications in patients presenting with possible catheter-related blood stream infection and early use of complementary tools such as trans-oesophageal echocardiography whenever applicable.
September 2017: JRSM Open
https://www.readbyqxmd.com/read/28899399/a-comparison-of-blood-stream-infections-with-extended-spectrum-beta-lactamase-producing-and-non-producing-klebsiella-pneumoniae-in-pediatric-patients
#16
Sevgen Tanır Basaranoglu, Yasemin Ozsurekci, Kubra Aykac, Eda Karadag Oncel, Asiye Bıcakcigil, Banu Sancak, Ali Bulent Cengiz, Ates Kara, Mehmet Ceyhan
BACKGROUND: Rapid development and global spread of multidrug resistant Klebsiella pneumonia (K. pneumoniae) as a major cause of nosocomial infections is really remarkable. The aim of this study was to explore risk factors for health care associated blood stream infections (BSI) caused by ESBL-producing K. pneumoniae in children and analyze clinical outcomes. METHODS: A retrospective review of patients younger than 18 years-old with blood stream infection caused by K...
September 12, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28892887/active-surveillance-of-health-care-associated-infections-in-neurosurgical-patients
#17
Reshu Agarwal, Sarita Mohapatra, Girija Prasad Rath, Arti Kapil
INTRODUCTION: Health Care Associated Infections (HCAI) are frequent complications in neurosurgery. There is limited data available on the incidence and burden of HCAI in neurosurgical patients of Southeast Asian region. AIM: To identify various HCAIs, associated aetiological agents and their antimicrobial susceptibility pattern among the patients admitted in the neurosurgery unit. MATERIALS AND METHODS: An observational prospective study was carried out for three months duration on all neurosurgical patients admitted to a tertiary-care center...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28883293/usefulness-of-a-peripherally-inserted-central-catheter-for-total-parenteral-nutrition-in-patients-with-inflammatory-bowel-disease
#18
Hirofumi Chiba, Katsuya Endo, Yasuhiro Izumiyama, Takeru Nakano, Daisuke Okamoto, Ryo Ichikawa, Hiroshi Nagai, Shin Matsumoto, Naonobu Yokoyama, Katsutoshi Yamamoto, Yusuke Shimoyama, Takeo Naito, Motoyuki Onodera, Jun Kusaka, Keiichiro Hiramoto, Masatake Kuroha, Yoshitake Kanazawa, Tomoya Kimura, Yoichi Kakuta, Yoshitaka Kinouchi, Tooru Shimosegawa
BACKGROUNDS AND AIMS: Peripherally inserted central catheters (PICC) have been widely used as a blood access route for total parenteral nutrition (TPN) in recent years. However, there have been few reports that evaluated the usefulness of PICC for patients with inflammatory bowel disease (IBD). In this study, we compared the clinical courses in patients with IBD who received TPN during their hospitalization by conventional central venous catheters (CVC) and PICC. PATIENTS AND METHODS: A total of 137 IBD patients were enrolled...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/28874412/isolation-of-a-membrane-protein-complex-for-type-vii-secretion-in-staphylococcus-aureus
#19
Khaled A Aly, Mark Anderson, Ryan Jay Ohr, Dominique Missiakas
The ESAT6-like secretion system (ESS) of Staphylococcus aureus promotes effector protein transport across the bacterial envelope. Genes in the ESS cluster are required for S. aureus establishment of persistent abscess lesions and the modulation of immune responses during blood stream infections. The biochemical functions of most of the ESS gene products, specifically the identity of secretion machine components, are however unknown. Earlier work demonstrated that deletion of essB, which encodes a membrane protein, abolishes S...
September 5, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28864361/healthcare-associated-infections-in-neonatal-intensive-care-unit-and-its-correlation-with-environmental-surveillance
#20
Sanjay Kumar, Binoy Shankar, Sugandha Arya, Manorma Deb, Harish Chellani
Healthcare-associated infections (HAI) are frequent complications in neonatal intensive care units (NICU) with varying risk factors and bacteriological profile. There is paucity of literature comparing the bacteriological profile of organisms causing HAI with the environmental surveillance isolates. Therefore, this study aimed to evaluate demographic profile, risk factors and outcome of HAI in NICU and correlate with environmental surveillance. Three hundred newborns with signs and symptoms of sepsis were enrolled in the study group and their profile, risk factors and outcome were compared with the control group...
August 29, 2017: Journal of Infection and Public Health
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