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Blood stream infection

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https://www.readbyqxmd.com/read/29909153/gastrointestinal-graft-versus-host-disease-is-a-risk-factor-for-post-engraftment-blood-stream-infection-in-allogeneic-hematopoietic-stem-cell-transplant-recipients
#1
Yasuo Mori, Goichi Yoshimoto, Ruriko Nishida, Takeshi Sugio, Kohta Miyawaki, Takahiro Shima, Yoji Nagasaki, Noriko Miyake, Yukiko Harada, Yuya Kunisaki, Kenjiro Kamezaki, Akihiko Numata, Koji Kato, Motoaki Shiratsuchi, Takahiro Maeda, Katsuto Takenaka, Hiromi Iwasaki, Nobuyuki Shimono, Koichi Akashi, Toshihiro Miyamoto
Bloodstream infection (BSI) is a well-known cause of morbidity and mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Here, we conducted a retrospective study to assess the morbidity, etiology, risk factors, and outcomes of BSI in the post-engraftment period (PE-BSI) following allo-HSCT. Forty-three out of 316 patients (13.6%) developed 57 PE-BSI episodes, in which 62 pathogens were isolated: gram-positive bacteria, gram-negative bacteria, and fungi, respectively, accounted for 54...
June 14, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29904809/effectiveness-of-antimicrobial-coated-central-venous-catheters-for-preventing-catheter-related-blood-stream-infections-with-the-implementation-of-bundles-a-systematic-review-and-network-meta-analysis
#2
REVIEW
Hongliang Wang, Hongshuang Tong, Haitao Liu, Yao Wang, Ruitao Wang, Hong Gao, Pulin Yu, Yanji Lv, Shuangshuang Chen, Guiyue Wang, Miao Liu, Yuhang Li, Kaijiang Yu, Changsong Wang
BACKGROUND: Catheter-related blood-stream infections (CRBSIs) are the most common complication when using central venous catheters (CVCs). Whether coating CVCs under bundles could further reduce the incidence of CRBSIs is unclear. We aimed to assess the effectiveness of implementing the use of bundles with antimicrobial-coated CVCs for preventing catheter-related blood-stream infections. METHODS: In this systematic review and network meta-analyses, we searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library in addition to the EMBASE, MEDLINE, CINAHL, and Web of Science databases for studies published before July 2017...
June 15, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29904138/acoustic-impedance-matched-buffers-enable-separation-of-bacteria-from-blood-cells-at-high-cell-concentrations
#3
Pelle Ohlsson, Klara Petersson, Per Augustsson, Thomas Laurell
Sepsis is a common and often deadly systemic response to an infection, usually caused by bacteria. The gold standard for finding the causing pathogen in a blood sample is blood culture, which may take hours to days. Shortening the time to diagnosis would significantly reduce mortality. To replace the time-consuming blood culture we are developing a method to directly separate bacteria from red and white blood cells to enable faster bacteria identification. The blood cells are moved from the sample flow into a parallel stream using acoustophoresis...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29863780/early-central-line-associated-blood-stream-infections-in-children-with-cancer-pose-a-risk-for-premature-catheter-removal
#4
Jacob Moell, Anna Svenningsson, Margareta Af Sandeberg, Magnus Larsson, Mats Heyman, Arja Harila-Saari, Anna Nilsson
AIM: This study examined the clinical characteristics of central line associated blood stream infections occurring within 30 days after insertion versus later infections in paediatric cancer patients, and the subsequent risk for premature catheter removal. METHODS: This was a retrospective study of children aged 0-18 years who were diagnosed with cancer from 2013-2014 at the Astrid Lindgren Children Hospital, Sweden. Clinical and microbiology data for each patient was collected for 365 days after the central venous catheter was inserted...
June 4, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29850436/common-uropathogens-among-diabetic-patients-with-urinary-tract-infection-at-jinja-regional-referral-hospital-uganda
#5
Barbara I Nabaigwa, Bashir Mwambi, John Okiria, Caesar Oyet
Between June 2015 and October 2015, 159 mid-stream urine samples from diabetic patients were cultured. The prevalence of urinary tract infection was high at 22% and women were more affected compared with men ( P = 0.017). Factors associated with urinary tract infection in these patients were age, sex and high blood glucose levels. Diabetic patients should be screened periodically for urinary tract infection.
2018: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/29812994/consequences-of-implementing-a-better-blood-culture-system
#6
Sarah E Posillico, Joseph F Golob, Brenda M Zosa, Nitin Sajankila, Laura A Kreiner, Jeffrey A Claridge
BACKGROUND: Blood cultures (BCx) are the gold standard for diagnosing blood stream infections. However, contamination remains a challenge and can increase cost, hospital days, and unnecessary antibiotic use. National goals are to keep overall BCx contamination rates to ≤3%. Our healthcare system recently moved to a BCx system with better organism recovery, especially for gram-negative, fastidious, and anaerobic bacteria. The study objectives were to determine the benefits/consequences of implementing a more sensitive blood culture system, specifically on contamination rates...
May 29, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29802046/pediatric-nurses-knowledge-values-and-implementation-of-evidence-based-practice-and-use-of-two-patient-safety-goals
#7
Linda Connor
PURPOSE: To describe knowledge, values, and implementation of evidence-based practice (EBP) and use of two National Patient Safety Goals-Central Line Associated Blood Stream Infections (CLABSI) and Surgical Site Infections (SSI)-between nurses working in Magnet® versus non-Magnet® designated hospitals. BACKGROUND: There is a gap in the literature concerning nurses' understanding of EBP and how EBP guidelines are used in practice and if guidelines are being used as intended...
May 22, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29801591/device-associated-nosocomial-infection-in-general-hospitals-kingdom-of-saudi-arabia-2013-2016
#8
Eiman Gaid, Abdullah Assiri, Scott McNabb, Weam Banjar
Healthcare-associated infections (HAIs) including device-associated HAI (DA-HAI) are a serious patient safety issue in hospitals worldwide, affecting 5-10% of hospitalized patients and deadly for patients in intensive care units (ICUs). (Vincent, 2003; Al-Tawfiq et al., 2013; Hu et al., 2013). DA-HAIs account for up to 23% of HAIs in ICUs and about 40% of all hospital infections (i.e. central line-associated blood stream infections [CLABSI], ventilator-associated pneumonia [VAP], and catheter-associated urinary tract infections [CAUTI])...
March 2018: Journal of Epidemiology and Global Health
https://www.readbyqxmd.com/read/29796365/maxillary-teeth-abscesses-result-in-atypical-liver-abscesses
#9
Ellecia Rainwater, Vritti Gupta, Renuga Vivekanandan, Gary Gorby
Hepatic liver abscesses are often misdiagnosed on initial presentation because pyogenic liver lesions are a rare occurrence in the United States. This leads to a delay in proper treatment and results in increasing morbidity and mortality. Our case report demonstrates the atypical presentation of a hepatic liver abscess in the elderly. The source of infection was found to be periapical abscesses of the teeth, which subsequently seeded the portal blood stream of our patient. Our findings validate the potential hazard of Viridans streptococci and illustrate how untreated dental infections can serve as a reservoir for a systemic infection...
March 20, 2018: Curēus
https://www.readbyqxmd.com/read/29790810/a-review-of-novel-technologies-and-techniques-associated-with-identification-of-bloodstream-infection-aetiologies-and-rapid-antimicrobial-genotypic-and-quantitative-phenotypic-determination
#10
Stephen Poole, Stephen P Kidd, Kordo Saeed
Introduction The antimicrobial aspect of management of patients with blood stream infections (BSI) and sepsis is time critical. In an era of increasing antimicrobial resistance, rapid detection and identification of bacteria with antimicrobial susceptibility is crucial to direct therapy early in the course of illness. Molecular techniques offer a potential solution to this. Areas covered In the present review the authors have discussed a number of novel solutions utilising a variety of molecular techniques for pathogen detection, identification and antimicrobial susceptibility...
May 23, 2018: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29768131/a-new-scoring-system-to-predict-blood-stream-infections-in-patients-with-complicated-intra-abdominal-infections-experience-from-a-tertiary-referral-hospital-in-china
#11
Jinjian Huang, Jianan Ren, Luise Brakert, Jiao Jiao, Qinjie Liu, Gefei Wang, Xiuwen Wu, Steven W M Olde Damink
BACKGROUND: This purpose of this study was to investigate the effects of blood stream infections (BSIs) on the prognosis of patients with complicated intra-abdominal infections (IAIs) and to make predictions based on patients' characteristics on admission. PATIENTS AND METHODS: One hundred eighty-seven patients with complicated IAI in 2014 and 2015 were included in our retrospective analysis, except for those diagnosed with central line-associated blood stream infections (CLABSIs)...
May 2018: Surgical Infections
https://www.readbyqxmd.com/read/29761673/neonatal-risk-factors-for-colonization-with-extended-spectrum-beta-lactamase-producing-bacteria-in-the-neonatal-intensive-care-unit
#12
Viktoria Leikin-Zach, Eilon Shany, Maayan Yitshak-Sade, Ron Eshel, Tali Shafat, Avraham Borer, Rimma Melamed
BACKGROUND: Extended-spectrum beta-lactamase (ESBL) production is the most common antimicrobial resistance mechanism in the neonatal intensive care unit (NICU), with colonization and blood stream infections being a major threat to this population. Since 2013, all NICU admissions at our facility were screened twice weekly for ESBL colonization. OBJECTIVES: To determine independent risk factors for colonization of infants with ESBL-producing bacteria in the NICU. METHODS: A retrospective case study of ESBL-colonized infants vs...
May 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29755085/-subdural-hematoma-after-open-heart-surgery-for-infective-endocarditis-presenting-with-pre-operative-intracranial-hemorrhage-infarction-report-of-a-case
#13
Ryuta Tai, Yosuke Kuroko, Makoto Mohri, Masakazu Yamaoka
A 47-year-old woman with a history of radiation enteritis and implantation of a central venous port was admitted to our intensive care unit(ICU) suffering from high fever. She was diagnosed with active infective endocarditis due to catheter-related blood stream infection. Although echocardiography showed a large vegetation on the mitral valve, surgical therapy was postponed for 5 weeks because of intracranial hemorrhage infarction. On the 3rd day after mitral valve repair, she developed consciousness disturbance and computed tomography(CT) revealed acute subdural hematoma of the posterior cranial fossa...
May 2018: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29738604/five-year-profile-of-candidemia-at-an-indian-trauma-center-high-rates-of-candida-auris-blood-stream-infections
#14
Purva Mathur, Fahmi Hasan, Pradeep Kumar Singh, Rajesh Malhotra, Kamini Walia, Anuradha Chowdhary
BACKGROUND: Candidemia is a potentially fatal infection with varied distribution of Candida species and their antifungal susceptibility profiles. The recent emergence of Candida auris in invasive candidiasis is a cause for concern. This study describes the profile of candidemia at an Indian tertiary care hospital and reports the emergence of Candida auris. METHODS: All patients diagnosed as having candidemia between 2012 to 2017 were studied. The isolates were identified using conventional methods, VITEK 2 and by the MALDI-TOF MS...
May 8, 2018: Mycoses
https://www.readbyqxmd.com/read/29737104/-antibiotic-resistance-and-risk-factors-for-mortality-of-blood-stream-infections-bsis-with-escherichia-coli-in-patients-with-hematological-malignancies
#15
Wei-Li Zhang, Jie Huang, Si-Ying Wu, Ya Liu, Fang Long, Yu-Ling Xiao, Yi Xie, Chao He, Mei Kang
OBJECTIVE: To analyze the risk factors for mortality of blood stream infections (BSIs) caused by Escherichia coli in the patients with hematological malignancies. METHODS: There were 110 Escherichia coli BSIs patients with hematological malignancies included in recent five years. Among them,77 cases had BSIs caused by extended-spectrum-beta-lactamase (ESBL)-producing Escherichia coli (ESBL-EC group),while 33 cases had BSIs with non-ESBL-producing Escherichia coli (non-ESBL-EC group)...
January 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/29733005/blood-stream-infection-in-patients-on-venovenous-extracorporeal-membrane-oxygenation-for-respiratory-failure
#16
Soo Jin Na, Chi Ryang Chung, Hee Jung Choi, Yang Hyun Cho, Jeong Hoon Yang, Gee Young Suh, Kyeongman Jeon
Bloodstream infection (BSI) occurred in 21 of 121 patients (17%) receiving venovenous extracorporeal membrane oxygenation within the median time of 6 days after initiation (interquartile range, 4-19 days). Longer duration of arterial catheterization and more blood transfusions were independently associated with BSI, which is associated with poor clinical outcomes.Infect Control Hosp Epidemiol 2018;1-4.
May 7, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29730396/can-serum-procalcitonin-aid-in-the-diagnosis-of-blood-stream-infection-in-patients-on-immunosuppressive-medications
#17
Rashi Arora, Nishant Sahni
BACKGROUND: Patients on immunosuppressive medications may not exhibit the systemic inflammatory response syndrome (SIRS) in the setting of bacterial infection. Our study examines the relationship between serum PCT levels and the odds of manifesting SIRS and BSI in patients on immunosuppressive medications and examines whether this relationship is altered from patients who are not on these medications. The diagnostic performance of Procalcitonin (PCT) detecting BSI in patients on immunosuppressive agents is compared to that in non-immunosuppressed patients...
May 3, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29730142/implementation-of-tailored-interventions-in-a-statewide-programme-to-reduce-central-line-associated-blood-stream-infections
#18
Denise B Assis, Geraldine Madalosso, Maria Clara Padoveze, Renata D Lobo, Maura S Oliveira, Ícaro Boszczowski, Julio M Singer, Anna S Levin
BACKGROUND: There is a scarcity of studies exploring implementation strategies to central line-associated bloodstream infections (CLABSI) in low or middle income countries. AIM: to implement tailored interventions to reduce CLABSI rates in adult intensive care units (ICU). METHODS: The implementation strategy of the State Health Department was performed in São Paulo State, Brazil over two cycles. Cycle 1 (56 hospitals) was exploratory and Cycle 2 (77 hospitals) was designed to confirm the hypothesis generated by the first cycle, with 3 phases each (pre-intervention, intervention, post-intervention)...
May 3, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29713464/an-observational-case-study-of-hospital-associated-infections-in-a-critical-care-unit-in-astana-kazakhstan
#19
Dmitriy Viderman, Yekaterina Khamzina, Zhannur Kaligozhin, Makhira Khudaibergenova, Agzam Zhumadilov, Byron Crape, Azliyati Azizan
Background: Hospital Associated infections (HAI) are very common in Intensive Care Units (ICU) and are usually associated with use of invasive devices in the patients. This study was conducted to determine the prevalence and etiological agents of HAI in a Surgical ICU in Kazakhstan, and to assess the impact of these infections on ICU stay and mortality. Objective: To assess the rate of device-associated infections and causative HAI etiological agents in an ICU at the National Research Center for Oncology and Transplantation (NRCOT) in Astana, Kazakhstan...
2018: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29690700/-the-state-of-the-art-research-findings-on-the-relationship-between-chronic-periodontitis-and-alzheimer-s-disease-a-review
#20
REVIEW
X S Qian, S Ge
Along with the development of periodontal medicine, there is a growing number of evidence showing that periodontitis could influence systemic health. Periodontitis is a chronic inflammatory disease caused by microbial infection mediated by dental plaque. Periodontal pathogenic microorganisms and its toxic products can disseminate through the blood stream or may cause the host immune response, which may lead to pathological changes of cerebral vessels and brain tissues to establish connection with Alzheimer's disease (AD)...
April 9, 2018: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
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