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https://www.readbyqxmd.com/read/28750507/improved-biosurfactant-production-by-bacillus-subtilis-spb1-mutant-obtained-by-random-mutagenesis-and-its-application-in-enhanced-oil-in-a-sand-system
#1
Mouna Bouassida, Semia Ellouze-Chaabouni, Dhouha Ghribi
Biosurfactants or microbial surfactants are surface-active biomolecules that are produced by a variety of microorganisms. Biodegradability and low toxicity have led to the intensification of scientific studies on a wide range of industrial applications for biosurfactants in the field of the environmental bioremediation as well as the petroleum industry and the enhanced oil recovery. However, the major bottlenecks in biosurfactant production are yield increase and cost reduction. Improving the bioindustrial production processes relies on many issues such as the use of cheap raw materials, the optimization of medium-culture conditions and selecting hyperproducing strains...
July 31, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28750494/brain-pet-and-functional-mri-why-simultaneously-using-hybrid-pet-mr-systems
#2
Diego Cecchin, Alessandro Palombit, Marco Castellaro, Erica Silvestri, Franco Bui, Henryk Barthel, Osama Sabri, Maurizio Corbetta, Alessandra Bertoldo
INTRODUCTION: In the last 20 years growing attention has been devoted to multimodal imaging. The recent literature is rich of clinical and research studies that have been performed using different imaging modalities on both separate and integrated Positron Emission Tomography (PET) and Magnetic Resonance (MR) scanners. However, today, hybrid PET/MR systems measure signals related to brain structure, metabolism, neurochemistry, perfusion, and neuronal activity simultaneously, i.e. in the same physiological conditions...
July 27, 2017: Quarterly Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28750489/patients-preferences-for-primary-colorectal-cancer-screening-a-survey-of-the-national-colorectal-cancer-screening-program-in-korea
#3
Young-Hak Cho, Dae Ho Kim, Jae Myung Cha, Yoon Tae Jeen, Jeong Seop Moon, Jin-Oh Kim, Sang Kil Lee, Yu Kyung Cho, Jong Pil Im, Jae Young Jang, Jeong Eun Shin, Soon Man Yoon, Yunho Jung, Eun Sun Kim, Kang Nyeong Lee, Soo-Jeong Cho, Yeol Kim, Bo Young Park
Background/Aims: The adoption of colonoscopy as a primary colorectal cancer (CRC) screening technique has been argued for in Korea, without evidence of patient preferences. This study aimed to investigate patients' preferences for the primary CRC screening test for the National Cancer Screening Program (NCSP). Methods: Between June and August 2016, 414 individuals aged ≥50 years who participated in the NCSP were prospectively invited to complete a questionnaire regarding their preferences for the primary CRC screening test and the reasons for their selection...
July 28, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28750488/serum-microrna-levels-as-a-noninvasive-diagnostic-biomarker-for-the-early-diagnosis-of-hepatitis-b-virus-related-liver-fibrosis
#4
Suxia Bao, Jianming Zheng, Ning Li, Chong Huang, Mingquan Chen, Qi Cheng, Kangkang Yu, Shengshen Chen, Mengqi Zhu, Guangfeng Shi
Background/Aims: To investigate the role of selected serum microRNA (miRNA) levels as potential noninvasive biomarkers for differentiating S0-S2 (early fibrosis) from S3-S4 (late fibrosis) in patients with a chronic hepatitis B virus (HBV) infection. Methods: One hundred twenty-three treatment-naive patients with a chronic HBV infection who underwent a liver biopsy were enrolled in this study. The levels of selected miRNAs were measured using a real-time quantitative polymerase chain reaction assay...
July 28, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28750486/assessment-of-the-risk-of-colorectal-cancer-survivors-developing-a-second-primary-pancreatic-cancer
#5
Joo Won Chung, Moon Jae Chung, Seungmin Bang, Seung Woo Park, Si Young Song, Jae Bock Chung, Jeong Youp Park
Background/Aims: We aimed to investigate the incidence of second primary pancreatic cancer (PC) after colorectal cancer (CRC) and to identify risk factors associated with subsequent PC. Methods: The observed incidence of a subsequent PC in patients with CRC was standardized using a population with CRC from the Korean Central Cancer Registry (KCCR). The expected incidence rate of PC was obtained by assuming that the select group experienced the same cancer incidence as the corresponding general population in the KCCR...
July 28, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28750482/infrared-ion-spectroscopy-inside-a-mass-selective-cryogenic-2d-linear-ion-trap
#6
Adam P Cismesia, Larry F Tesler, Matthew R Bell, Laura S Bailey, Nicolas C Polfer
We demonstrate operation of the first cryogenic 2D linear ion trap (LIT) with mass-selective capabilities. This trap presents a number of advantages for infrared ion "action" spectroscopy studies, particularly those employing the "tagging/messenger" spectroscopy approach. The high trapping efficiencies, trapping capacities, and low detection limits make 2D LITs a highly suitable choice for low-concentration analytes from scarce biological samples. In our trap, ions can be cooled down to cryogenic temperatures to achieve higher-resolution infrared spectra, and individual ions can be mass selected prior to irradiation for a background-free photodissociation scheme...
July 27, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28750475/inpatient-glucose-management-programme-in-the-asian-healthcare-setting
#7
Du Soon Swee, Li Chang Ang, Wee May Heng, Desmond Xue-Yuan Lee, Xiaohui Xin, Shalini Kumaran, Kok Seng Wong, Yong Mong Bee, Su-Yen Goh, Ming Ming Teh
AIM: To implement an inpatient glucose management (IGM) programme in the general medical wards and evaluate its clinical efficacy. METHOD: Consecutive patients admitted to selected medical wards over a 12-month period were included in the IGM programme. All patients with ≥3 capillary blood glucose (CBG) readings (>10.0 mmol/L and/or <4.0 mmol/L) over a 24-hour period were identified electronically. A multidisciplinary team of diabetes care providers would provide specialist input to these patients...
July 27, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28750371/mitochondrial-fission-inhibitors-suppress-endothelin-1-induced-artery-constriction
#8
Chang Chen, Jin-Lai Gao, Ming-Yu Liu, Shan-Liang Li, Xiu-Chen Xuan, Xin-Zi Zhang, Xi-Yue Zhang, Yuan-Yuan Wei, Chang-Lin Zhen, Jing Jin, Xin Shen, De-Li Dong
BACKGROUND/AIMS: Endothelin-1 is implicated in the pathogenesis of hypertension, but the underlying mechanisms remained elusive. Our previous study found that inhibition of mitochondrial fission of smooth muscle cells suppressed phenylephrine- and high K+-induced artery constriction. Here, we studied the effects of mitochondrial fission inhibitors on endothelin-1-induced vasoconstriction. METHODS: The tension of rat mesenteric arteries and thoracic aorta was measured by using a multi-wire myograph system...
July 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28750369/matrix-metalloproteinase-polymorphisms-in-patients-with-floppy-mitral-valve-mitral-valve-prolapse-fmv-mvp-and-fmv-mvp-syndrome
#9
Sarah M Lima, Antonios A Pitsis, Timotheos G Kelpis, Mohamed H Shahin, Taimour Y Langaee, Larisa H Cavallari, Efstratios K Theofilogiannakos, Harisios Boudoulas, Konstantinos Dean Boudoulas
BACKGROUND: It has been suggested that collagen abnormalities of the mitral valve are present in patients with floppy mitral valve (FMV)/mitral valve prolapse (MVP). Genetic factors determining collagen synthesis and degradation have not been well defined in these patients. This study was undertaken to determine whether selective polymorphisms of matrix metalloproteinase-2 (MMP2) or transforming growth factor-β (TGFβ), with known or putative effects on collagen turnover, are more frequent in FMV/MVP...
July 28, 2017: Cardiology
https://www.readbyqxmd.com/read/28750352/modelling-the-external-radiation-exposure-from-the-chernobyl-fallout-using-data-from-the-swedish-municipality-measurement-system
#10
Mattias Jönsson, Martin Tondel, Mats Isaksson, Robert Finck, Robert Wålinder, Afrah Mamour, Christopher Rääf
In connection with the Chernobyl fallout and the subsequent deposition of radionuclides in Sweden, Swedish municipalities launched a measurement program to monitor the external radiation exposure. This program encompasses measurements of the ambient dose equivalent rate 1 m above ground at selected locations, and repeats those measurements at the same locations at 7-month intervals. Measurement data compiled from the seven locations with the highest deposition were combined with data from aerial surveys since May 1986 of ground deposition of (137)Cs, high-resolution gamma spectrometry performed at four locations in May 1986, and measurements from fixed continuous air gamma rate monitoring stations from 28 April to 15 May 1986...
July 24, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28750349/escherichia-coli-maltose-binding-protein-mbp-activates-mouse-th1-through-tlr2-mediated-myd88-dependent-pathway-and-tlr4-mediated-trif-dependent-pathway
#11
GuoMu Liu, YiXin Zhang, NanNan Zhang, WeiHua Ni, Jing Jie, LiNa Jiang, GuiXiang Tai
MBP (maltose-binding protein) is a component of Escherichia coli. Our previous study found that MBP directly induces the activation of Th1 (T helper type 1), but the molecular mechanism remains unclear. In the present study, CD4(+)T cells were purified from the spleens of normal mice using antibody-coated immunomagnetic beads by negative selection. CD4(+)T cells activated with a CD3/CD28 antibody were stimulated with MBP. The results indicated that MBP elevated IFN-γ mRNA levels in activated CD4(+)T cells and promoted IFN-γ production from activated CD4(+)T cells...
July 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28750344/aerosol-pollution-and-its-potential-impacts-on-outdoor-human-thermal-sensation-east-asian-perspectives
#12
Ka-Ming Wai, Edward Y Y Ng, Charles M S Wong, Tanya Z Tan, Tang-Huang Lin, Wei-Hung Lien, Peter A Tanner, Carlo S H Wang, Kevin K L Lau, Neon M H He, Jhoon Kim
Aerosols affect the insolation at ground and thus the Aerosol Optical Depth (AOD, a measure of aerosol pollution) plays an important role on the variation of the Physiological Equivalent Temperature (PET) at locations with different aerosol climatology. The aerosol effects upon PET were studied for the first time at four East Asian cities by coupling a radiative transfer model and a human thermal comfort model which were previously well evaluated. Evident with the MODIS and AERONET AOD observations, the aerosol pollution at Beijing and Seoul was higher than at Chiayi (Taiwan) and Hong Kong...
July 24, 2017: Environmental Research
https://www.readbyqxmd.com/read/28750341/the-enzyme-sensitive-release-of-prodigiosin-grafted-%C3%AE-cyclodextrin-and-chitosan-magnetic-nanoparticles-as-an-anticancer-drug-delivery-system-synthesis-characterization-and-cytotoxicity-studies
#13
Banafsheh Rastegari, Hamid Reza Karbalaei-Heidari, Sedigheh Zeinali, Heather Sheardown
In present investigation, two glucose based smart tumor-targeted drug delivery systems coupled with enzyme-sensitive release strategy are introduced. Magnetic nanoparticles (Fe3O4) were grafted with carboxymethyl chitosan (CS) and β-cyclodextrin (β-CD) as carriers. Prodigiosin (PG) was used as the model anti-tumor drug, targeting aggressive tumor cells. The morphology, properties and composition and grafting process were characterized by transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FT-IR), vibration sample magnetometer (VSM), X-ray diffraction (XRD) analysis...
July 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28750337/self-cleaned-electrochemical-protein-imprinting-biosensor-basing-on-a-thermo-responsive-memory-hydrogel
#14
Yubo Wei, Qiang Zeng, Qiong Hu, Min Wang, Jia Tao, Lishi Wang
Herein, the self-cleaned electrochemical protein imprinting biosensor basing on a thermo-responsive memory hydrogel was constructed on a glassy carbon electrode (GCE) with a free radical polymerization method. Combining the advantages of thermo-responsive molecular imprinted polymers and electrochemistry, the resulted biosensor presents a novel self-cleaned ability for bovine serum albumin (BSA) in aqueous media. As a temperature controlled gate, the hydrogel film undergoes the adsorption and desorption of BSA basing on a reversible structure change with the external temperature stimuli...
July 20, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28750336/recent-advances-in-biosensor-technology-in-assessment-of-early-diabetes-biomarkers
#15
REVIEW
Armin Salek-Maghsoudi, Faezeh Vakhshiteh, Raheleh Torabi, Shokoufeh Hassani, Mohammad Reza Ganjali, Parviz Norouzi, Morteza Hosseini, Mohammad Abdollahi
Discovery of biosensors has acquired utmost importance in the field of healthcare. Recent advances in biological techniques and instrumentation involving nanomaterials, surface plasmon resonance, and aptasensors have developed innovative biosensors over classical methods. Integrated approaches provided a better perspective for developing specific and sensitive devices with wide potential applications. Type 2 diabetes mellitus is a complex disease affecting almost every tissue and organ system, with metabolic complications extending far beyond impaired glucose metabolism...
July 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28750322/longitudinal-sequencing-of-hiv-1-infected-patients-with-low-level-viremia-for-years-while-on-art-shows-no-indications-for-genetic-evolution-of-the-virus
#16
Leen Vancoillie, Laura Hebberecht, Kenny Dauwe, Els Demecheleer, Sylvie Dinakis, Dries Vaneechoutte, Virginie Mortier, Chris Verhofstede
HIV-infected patients on antiretroviral therapy (ART) may present low-level viremia (LLV) above the detection level of current viral load assays. In many cases LLV is persistent but does not result in overt treatment failure or selection of drug resistant viral variants. To elucidate whether LLV reflects active virus replication, we extensively sequenced pol and env genes of the viral populations present before and during LLV in 18 patients and searched for indications of genetic evolution. Maximum likelihood phylogenetic trees were inspected for temporal structure both visually and by linear regression analysis of root-to-tip and pairwise distances...
July 24, 2017: Virology
https://www.readbyqxmd.com/read/28750312/synthesis-of-2-imino-and-2-hydrazono-thiazolo-4-5-d-pyrimidines-as-corticotropin-releasing-factor-crf-antagonists
#17
Mohamed Teleb, Bhimanna Kuppast, Katerina Spyridaki, George Liapakis, Hesham Fahmy
Corticotropin-releasing factor (CRF) is an important neuropeptide hormone which controls the body's overall response to stress. It plays a crucial role in regulating the behavioral, cardiovascular, immune and gastrointestinal systems. Over-activation of the CRF system has been implicated in many disorders including anxiety, depression, drug addiction, hypertension, Irritable Bowel Syndrome (IBS), peptic ulcers, inflammation and others. Thus, binding of CRF to its receptors is an attractive target to develop new medications which aim at treating ailments associated with chronic stress...
July 18, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28750294/freezability-genetics-in-rabbit-semen
#18
R Lavara, E Mocé, M Baselga, J S Vicente
The aim of this study was to estimate the heritability of semen freezability and to estimate the genetic correlation between frozen-thawed sperm traits and the growth rate in a paternal rabbit line. Estimated heritabilities showed that frozen-thawed semen traits are heritable (ranged between 0.08 and 0.15). In the case of Live-FT (percentage of viable sperm after freezing), the estimated heritability is the highest one, and suggests the possibility of effective selection. After the study of genetic correlations it seems that daily weight gain (DG) was negatively correlated with sperm freezability, but no further conclusions could be drawn due to the high HPD95%...
July 17, 2017: Theriogenology
https://www.readbyqxmd.com/read/28750272/medication-use-and-kidney-cancer-risk-a%C3%A2-population-based-study
#19
Madhur Nayan, David N Juurlink, Peter C Austin, Erin M Macdonald, Antonio Finelli, Girish S Kulkarni, Robert J Hamilton
BACKGROUND: Exposure to commonly prescribed medications may be associated with cancer risk. However, there is limited data in kidney cancer. Furthermore, methods of classifying cumulative medication exposure in previous studies may be prone to bias. METHODS: We conducted a population-based case-control study of 10,377 incident kidney cancer cases aged ≥66 years matched with 35,939 controls on age, sex, history of hypertension, comorbidity score, and geographic location...
July 24, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28750271/safety-tolerability%C3%A2-and-antitumour-activity-of-ly2780301-p70s6k-akt-inhibitor-in-combination-with-gemcitabine-in-molecularly-selected-patients-with-advanced-or-metastatic-cancer-a-phase-ib-dose-escalation-study
#20
Eric Angevin, Philippe A Cassier, Antoine Italiano, Anthony Gonçalves, Anas Gazzah, Catherine Terret, Maud Toulmonde, Gwenaëlle Gravis, Andrea Varga, Cédric Parlavecchio, Angelo Paci, Vianney Poinsignon, Jean-Charles Soria, Damien Drubay, Antoine Hollebecque
BACKGROUND: LY2780301, a dual inhibitor of protein kinase B (AKT) and the downstream effector p70 ribosomal protein S6 kinase (p70S6K), may inhibit progression in tumours relying on phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signalling pathway activation. This phase IB trial investigated the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), safety, pharmacokinetics (PK) and antitumour activity of LY2780301 plus gemcitabine in patients with advanced/metastatic solid tumours...
July 24, 2017: European Journal of Cancer
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