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https://www.readbyqxmd.com/read/28631396/pttg3p-promotes-gastric-tumour-cell-proliferation-and-invasion-and-is-an-indicator-of-poor-prognosis
#1
Weiwei Weng, Shujuan Ni, Yiqin Wang, Midie Xu, Qiongyan Zhang, Yusi Yang, Yong Wu, Qinghua Xu, Peng Qi, Cong Tan, Dan Huang, Ping Wei, Zhaohui Huang, Yuqing Ma, Wei Zhang, Weiqi Sheng, Xiang Du
Pseudogenes play a crucial role in cancer progression. However, the role of pituitary tumour-transforming 3, pseudogene (PTTG3P) in gastric cancer (GC) remains unknown. Here, we showed that PTTG3P expression was abnormally up-regulated in GC tissues compared with that in normal tissues both in our 198 cases of clinical samples and the cohort from The Cancer Genome Atlas (TCGA) database. High PTTG3P expression was correlated with increased tumour size and enhanced tumour invasiveness and served as an independent negative prognostic predictor...
June 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28623157/mortality-and-antipsychotic-drug-use-in-elderly-patients-with-parkinson-disease-in-nursing-homes
#2
Dao Thu Trang, Charlène Cool, Clarisse Laffon de Mazieres, Maryse Lapeyre-Mestre, Jean-Louis Montastruc, Olivier Rascol, Yves Rolland, Agnès Sommet
OBJECTIVES: To evaluate mortality rate in elderly and very elderly (≥85 years) residents with Parkinson disease (PD) in nursing homes (NHs) with and without antipsychotic drugs. DESIGN: Cross-sectional study. PARTICIPANTS: All residents with PD from the 6275 NH residents participating in the Impact d'une démarche QUAlité sur l'évolution des pratiques et le déclin fonctionnel des Résidents en Etablissement d'hébergement pour personnes âgées dépendantes (IQUARE) study...
June 13, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28602114/combination-of-chimneys-and-fenestrated-endografts-in-the-treatment-of-complex-aortic-aneurysms
#3
Caroline Caradu, Julien Morin, Dominique Midy, Sandro Lepidi, Eric Ducasse
PURPOSE: To present early results of fenestrated endovascular aneurysm repair (FEVAR) combined with chimney grafts in a high-volume center. METHODS: From July 2011 to July 2016, 45 patients (mean age 73.0±8.8 years; 39 men) with complex aneurysms who were poor candidates for open repair and anatomically ineligible for standard or custom-made FEVAR were treated with chimney FEVAR (chFEVAR). Eight (18%) cases were treated in emergency. In all, 130 target vessels (2...
June 1, 2017: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/28583818/a-multicenter-study-of-1144-patients-with-cerebral-venous-thrombosis-the-venost-study
#4
Taskin Duman, Derya Uluduz, Ipek Midi, Hesna Bektas, Yuksel Kablan, Basak K Goksel, Aysel Milanlioglu, Dilek Necioglu Orken, Ufuk Aluclu
BACKGROUND: Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. METHODS: All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution...
June 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28570711/igf1-and-igf2-specificities-to-the-two-insulin-receptor-isoforms-are-determined-by-insulin-receptor-amino-acid-718
#5
Mie Andersen, Dorte Nørgaard-Pedersen, Jakob Brandt, Ingrid Pettersson, Rita Slaaby
METHODS: Alanine scan of insulin receptor (IR)-B exon 11 and site-directed mutagenesis of amino acid 718 in human IR-A and IR-B were performed. Ligand affinities to wild type and mutated receptors were studied by displacement of radioactive insulin in binding assay on secreted soluble midi receptors or solubilized semi-purified full length receptors stably expressed in Baby Hamster Kidney cells. Phosphorylation of IR in response to insulin, IGF1 and IGF2 was measured using ELISA. RESULTS: Insulin, insulin detemir and insulin glargine maximally showed two fold differences in affinity for human IR-A and IR-B, but IGF1 and IGF2 had up to 10 fold preference for IR-A...
2017: PloS One
https://www.readbyqxmd.com/read/28543710/presentation-diagnosis-and-management-of-popliteal-artery-entrapment-syndrome-11-years-of-experience-with-61-legs
#6
Luc Corneloup, Claude Labanère, Laurent Chevalier, Jérémie Jaussaud, Aude Mignot, Laurent Gencel, Olivier Corneloup, Dominique Midy
BACKGROUND: Popliteal Artery Entrapment Syndrome (PAES) is still underdiagnosed yet it may significantly interfere with lifestyle, especially among young sportspeople, with symptoms like intermittent claudication. While case reports and small case series are sometimes published, studies with larger populations are quite rare. METHODS: This study summarizes our experience with PAES on 61 limbs (35 patients) over a period of 11 years, describing the demographics, the disease and the diagnostic and therapeutic methods used with PAES patients...
May 19, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28528715/embolization-for-persistent-type-ia-endoleaks-after-chimney-endovascular-aneurysm-repair-with-onyx-%C3%A2
#7
C Marcelin, Y Le Bras, F Petitpierre, D Midy, N Grenier, E Ducasse, F Cornélis
PURPOSE: The purpose of this study was to determine retrospectively the safety and technical success rate of embolization using ethylene vinyl alcohol copolymer (Onyx(®)) for persistent type 1A endoleaks after chimney endovascular aneurysm repair (EVAR) for complex aortic aneurysms. MATERIAL AND METHODS: Nine consecutive patients (6 men, 3 women) with a mean age of 78.6 years (range: 62-87 years) presenting with persistent type IA endoleaks after chimney EVAR and an increase of aneurysm size were treated using transarterial embolization with Onyx(®)...
May 18, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/28495540/results-of-the-french-multicentric-study-of-anaconda-tm-fenestrated-endografts-in-the-treatment-of-complex-aortic-pathologies-efefa-registry
#8
Dominique Midy, Jean-Pierre Becquemin, Claude Mialhe, Nicolas Frisch, Robert Martinez, Caroline Caradu
BACKGROUND: Most of the experience on fenestrated endovascular aneurysm repair (F-EVAR) involves the custom-made Zenith® endograft (Cook). The fenestrated Anaconda® endograft (Vascutek) was introduced with the potential advantages of complete repositioning and lack of stent material on the main aortic body for more versatility. However, few data are available. Our objective was to assess its mid-term results in the treatment of complex aortic aneurysms. METHODS: Consecutive patients treated with the custom-made Fenestrated Anaconda® Endograft in France and the Principality of Monaco, from December 2010 to October 2015, were included...
May 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28486938/barriers-and-facilitators-related-to-the-uptake-of-four-strategies-to-prevent-neonatal-early-onset-group-b-haemolytic-streptococcus-disease-a-qualitative-study
#9
Diny G E Kolkman, Margot A H Fleuren, Maurice G A J Wouters, Christianne J M de Groot, Marlies E B Rijnders
BACKGROUND: Actions to prevent early onset disease in neonates are based on different strategies including administering antibiotic prophylaxis during labour in case of 1) maternal GBS colonisation (screening strategy), 2) identified risk factors (risk-based strategy) or 3) a combination of these two conditions (maternal GBS colonisation and identified risk factors: combination strategy and the Dutch guideline). Low adherence to guidelines preventing EOGBS has been reported. Each strategy has drawbacks and clinical outcomes are affected by care providers' and women's adherence...
May 9, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28458648/pitch-syntax-violations-are-linked-to-greater-skin-conductance-changes-relative-to-timbral-violations-the-predictive-role-of-the-reward-system-in-perspective-of-cortico-subcortical-loops
#10
Edward J Gorzelańczyk, Piotr Podlipniak, Piotr Walecki, Maciej Karpiński, Emilia Tarnowska
According to contemporary opinion emotional reactions to syntactic violations are due to surprise as a result of the general mechanism of prediction. The classic view is that, the processing of musical syntax can be explained by activity of the cerebral cortex. However, some recent studies have indicated that subcortical brain structures, including those related to the processing of emotions, are also important during the processing of syntax. In order to check whether emotional reactions play a role in the processing of pitch syntax or are only the result of the general mechanism of prediction, the comparison of skin conductance levels reacting to three types of melodies were recorded...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28444896/agreement-between-finger-plethysmography-and-brachial-oscillometry-derived-blood-pressure-measurements
#11
Philip D Allan, Terrence O'Donnell, Yu-Chieh Tzeng
PURPOSE: Blood pressure (BP) is commonly assessed by brachial oscillometry in clinical practice, whereas in physiological studies, finger plethysmography is often employed. This study assessed the limits of agreement between BP metrics obtained from each device. METHODS: In 96 participants, we simultaneously recorded BP by brachial oscillometry (BP+; Uscom, Sydney, NSW, Australia) and finger plethysmography (Finometer MIDI, MLE1054-V; Finapres Medical Systems B...
April 26, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28433120/additional-cost-because-of-pneumonia-in-nursing-home-residents-results-from-the-incidence-of-pneumonia-and-related-consequences-in-nursing-home-resident-study
#12
Nadège Costa, Emiel O Hoogendijk, Michael Mounié, Robert Bourrel, Yves Rolland, Bruno Vellas, Laurent Molinier, Matteo Cesari
OBJECTIVES: Pneumonia is a frequent condition in older people. Our aim was to examine the total healthcare cost related to pneumonia in nursing home (NH) residents over a 1-year follow-up period. DESIGN: This was a prospective, longitudinal, observational, and multicenter study that was a part of the Incidence of Pneumonia and related Consequences in Nursing Home Resident study. SETTING: Thirteen NHs located in Languedoc Roussillon and Midi-Pyrénées regions in France were included...
May 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28361195/percutaneous-image-guided-cryoablation-as-second-line-therapy-of-soft-tissue-venous-vascular-malformations-of-extremities-a-prospective-study-of-safety-and-6-month-efficacy
#13
F H Cornelis, C Labrèze, V Pinsolle, Y Le Bras, C Castermans, C Bader, R Thiebaut, D Midy, N Grenier
PURPOSE: To report the safety and short-term efficacy of percutaneous image-guided cryoablation performed as second-line therapy of venous vascular malformations (VVM) of extremities. MATERIALS AND METHODS: In this non-blinded, no-randomized trial, cryoablation was proposed in 14 patients presenting with symptomatic VVM for recurrences after treatment. Eligibility criteria were: cryoablation feasible, localization at least 5 mm from skin and nerves, absence of contra-indication for anesthesia...
March 30, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28335159/monocentric-evaluation-of-endovascular-repair-of-juxta-renal-abdominal-aortic-aneurysms-by-the-chimney-technique-vs-fenestrated-stentgrafts
#14
Caroline Caradu, Julien Morin, Mathieu Poirier, Dominique Midy, Eric Ducasse
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335151/use-of-biosynthetic-prostheses-to-treat-bypasses-infections
#15
Bertrand Saint-Lebes, Xavier Berard, Eric Ducasse, Xavier Chaufour, Jean-Pierre Bossavy, Dominique Midy
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28258015/influence-of-anatomic-angulations-in-chimney-and-fenestrated-endovascular-aneurysm-repair
#16
Caroline Caradu, Xavier Bérard, Dominique Midy, Eric Ducasse
BACKGROUND: Fenestrated (F-) endovascular aneurysm repair (EVAR)'s lack of widespread availability encouraged alternative strategies. Chimney graft (CG)-EVAR has spread when costs, manufacturing delays or anatomy preclude F-EVAR. Our objective was to evaluate CG-EVAR and F-EVAR's outcomes depending on the angulation of target renal arteries and hostility of iliac accesses to determine the potential impact of a choice made between the two techniques based upon preoperative anatomic criteria...
February 28, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28241812/effects-of-various-debonding-and-adhesive-clearance-methods-on-enamel-surface-an-in-vitro-study
#17
Xiao-Chuan Fan, Li Chen, Xiao-Feng Huang
BACKGROUND: The purpose of this study was to evaluate orthodontic debonding methods by comparing the surface roughness and enamel morphology of teeth after applying two different debonding methods and three different polishing techniques. METHODS: Forty eight human maxillary premolars, extracted for orthodontic reasons, were randomly divided into three groups. Brackets were bonded to teeth with RMGIC (Fuji Ortho LC, GC, Tokyo, Japan) (two groups, n = 18 each) after acid etching (30s), light cured for 40 s, exposed to thermocycling, then underwent 2 different bracket debonding methods: debonding pliers (Shinye, Hangzhou, China) or enamel chisel (Jinzhong, Shanghai, China); the third group (n = 12) comprised of untreated controls, with normal enamel surface roughness...
February 27, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/28240787/newly-diagnosed-immune-thrombocytopenia-adults-clinical-epidemiology-exposure-to-treatments-and-evolution-results-of-the-carmen-multicenter-prospective-cohort
#18
Guillaume Moulis, Johanne Germain, Thibault Comont, Natacha Brun, Claire Dingremont, Brice Castel, Sophie Arista, Laurent Sailler, Maryse Lapeyre-Mestre, Odile Beyne-Rauzy, Bertrand Godeau, Daniel Adoue
The clinical epidemiology of immune thrombocytopenia (ITP) is not well known in adults. This study was aimed at assessing the clinical epidemiology of incident ITP adults, the factors associated with chronicity and exposure to treatments. This study was conducted in the CARMEN registry, a multicentric prospective cohort aimed at including all newly diagnosed ITP adults in the French Midi-Pyrénées region, South of France (3 million inhabitants) from June 2013. Descriptive analyses and multivariate logistic regression models were conducted...
June 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28239898/early-signal-of-diverted-use-of-tropicamide-eye-drops-in-france
#19
Camille Ponté, Christian Pi, Aurore Palmaro, Emilie Jouanjus, Maryse Lapeyre-Mestre
BACKGROUND: Tropicamide is a mydriatic drug used as eye-drops for diagnostic or therapeutic purposes. From 2013, a diverted use by intravenous route has been suspected in Eastern Europe in opioids users. To recent date, no signal of a misuse has been identified in France. PURPOSE: To investigate an early signal of a diverted use of tropicamide eye drops and to collect information regarding motives of misusing and tropicamide-induced effects. METHODS: Information was obtained at 1/ regional level (Midi-Pyrénées area): reimbursement data and pharmacists' reports on suspicious requests, 2/ national level: reimbursement data and prescriptions suggesting possible abuse from the OSIAP (Ordonnances Suspectes, Indicateur d'Abus Possible) survey and 3/ international level: VigiBase® reports and Web sources...
February 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28198064/real-life-practices-for-preventing-venous-thromboembolism-in-multiple-myeloma-patients-a-cohort-study-from-the-french-health-insurance-database
#20
Aurore Palmaro, Marie-Eve Rougé-Bugat, Martin Gauthier, Fabien Despas, Guillaume Moulis, Maryse Lapeyre-Mestre
PURPOSE: The risk of venous thromboembolic event (VTE) in multiple myeloma is particularly increased. Current guidelines recommend systematic VTE prophylaxis with vitamin K antagonists (VKA) or low weight molecular heparin (LWMH) or unfractionated heparin (UFH) in high-risk patients, based on treatment received [e.g. use of IMiDs (thalidomide, lenalidomide and pomalidomide), alkylating agents or erythropoietin] and individual risk factors (e.g. history of VTE). The aim of this study was to describe strategy of VTE prophylaxis and prescribing of other antithrombotic agents during the first 6 months of multiple myeloma therapy, with stratification on IMiD-based regimens and drug and disease-related risk factors...
February 15, 2017: Pharmacoepidemiology and Drug Safety
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