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Glucosamine AND chondroitin

Patrick B Wilson
OBJECTIVES: Sparse data are available to describe the prevalence of dietary supplementation among individuals with arthritis. Using a nationally representative sample, this investigation assessed the prevalence of dietary supplement use among Americans self-reporting arthritis. SETTING AND DESIGN: Data from 4606 participants of the 2011-2012 National Health and Nutrition Examination Survey were analyzed, including from 1170 participants self-reporting arthritis...
December 2016: Complementary Therapies in Medicine
Hyung Joo Suh, Hyunji Lee, Byung Jung Min, Sung Ug Jung, Eun Young Jung
BACKGROUND/OBJECTIVES: We investigated the anti-osteoarthritic effects of deer bone extract on the gene expressions of matrix metalloproteinases (MMPs) and collagen type II (COL2) in interleukin-1β-induced osteoarthritis (OA) chondrocytes. MATERIALS/METHODS: Primary rabbit chondrocytes were treated as follows: CON (PBS treatment), NC (IL-1β treatment), PC (IL-1β + 100 µg/mL glucosamine sulphate/chondroitin sulphate mixture), and DB (IL-1β + 100 µg/mL deer bone extract)...
December 2016: Nutrition Research and Practice
Jorge A Roman-Blas, Aránzazu Mediero, Lidia Tardío, Sergio Portal-Nuñez, Paula Gratal, Gabriel Herrero-Beaumont, Raquel Largo
Osteoarthritis is the most common chronic joint disorder especially during aging. Although with controversies, glucosamine, both in its forms of sulfate and hydrochloride, and chondroitin sulfate are commonly employed to treat osteoarthritis. Due to the modest improve in the symptoms observed in patients treated with these drugs alone, a formulation combining both agents has been considered. The discrepant results achieved for pain control or structural improvement in osteoarthritis patients has been attributed to the quality of chemical formulations or different bias in clinical studies...
November 12, 2016: European Journal of Pharmacology
R M A Packer, I J Seath, D G O'Neill, S De Decker, H A Volk
BACKGROUND: Intervertebral disc disease (IVDD) represents a major problem in the Dachshund, with at a relative risk of IVDD 10-12 times higher than other breeds, and an estimated 19-24 % of Dachshunds showing clinical signs related to IVDD during their lifetime. A variety of genetic, physical and lifestyle-related risk factors for IVDD have previously been identified, with some conflicting findings. As such, advising owners and breeders regarding best-practice for IVDD prevention is challenging at present...
2016: Canine Genetics and Epidemiology
David D Frisbie, C Wayne McIlwraith, Christopher E Kawcak, Natasha M Werpy
OBJECTIVE To evaluate the efficacy of IV administration of a product containing hyaluronan, sodium chondroitin sulfate, and N-acetyl-d-glucosamine for prevention or treatment of osteoarthritis in horses. ANIMALS 32 healthy 2- to 5-year-old horses. PROCEDURES The study involved 2 portions. To evaluate prophylactic efficacy of the test product, horses received 5 mL of the product (n = 8) or saline (0.9% NaCl) solution (8; placebo) IV every fifth day, starting on day 0 (when osteoarthritis was induced in the middle carpal joint of 1 forelimb) and ending on day 70...
October 2016: American Journal of Veterinary Research
Richard L Nahin, Robin Boineau, Partap S Khalsa, Barbara J Stussman, Wendy J Weber
Although most pain is acute and resolves within a few days or weeks, millions of Americans have persistent or recurring pain that may become chronic and debilitating. Medications may provide only partial relief from this chronic pain and can be associated with unwanted effects. As a result, many individuals turn to complementary health approaches as part of their pain management strategy. This article examines the clinical trial evidence for the efficacy and safety of several specific approaches-acupuncture, manipulation, massage therapy, relaxation techniques including meditation, selected natural product supplements (chondroitin, glucosamine, methylsulfonylmethane, S-adenosylmethionine), tai chi, and yoga-as used to manage chronic pain and related disability associated with back pain, fibromyalgia, osteoarthritis, neck pain, and severe headaches or migraines...
September 2016: Mayo Clinic Proceedings
Jorge A Roman-Blas, Santos Castañeda, Olga Sánchez-Pernaute, Raquel Largo, Gabriel Herrero-Beaumont
OBJECTIVE: To assess the efficacy and safety of chondroitin sulfate (CS) plus glucosamine sulfate (GS) compared to placebo in patients with symptomatic knee osteoarthritis (KOA). METHODS: A multicenter, randomized, double-blinded, placebo-controlled study was performed in 164 patients with Kellgren-Lawrence stages II-III KOA and moderate to severe pain (VAS: 62.1±11.3 mm). Patients were randomized to receive either CS (1200 mg) plus GS (1500 mg) or placebo in a single oral daily dose for 6 months...
July 31, 2016: Arthritis & Rheumatology
Artur M Pinto, J Agostinho Moreira, Fernão D Magalhães, Inês C Gonçalves
The biointeractions of graphene-based materials depend on their physico-chemical properties. These properties can be manipulated by polymer adsorption. Graphene nanoplatelets (GNP-C) were modified with PVA, HEC, PEG, PVP, chondroitin, glucosamine, and hyaluronic acid. These materials were characterized by SEM, DLS, XPS, Raman spectroscopy, and TGA. Surface adsorption was confirmed for all polymers. Biocompatibility evaluation showed that all of these materials induced low haemolysis (<1.7%) at concentrations up to 500μgmL(-1)...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
Noriyuki Kanzaki, Yuta Otsuka, Takayuki Izumo, Hiroshi Shibata, Hideyuki Nagao, Keita Ogawara, Hiroshi Yamada, Seiji Miyazaki, Yutaka Nakamura
BACKGROUND: Previously, we demonstrated that glucosamine-containing supplementation was effective for improving locomotor functions, especially walking speed. However, the biomechanical mechanism of efficacy has not been elucidated. This study aimed to address this challenge in subjects with knee pain, using a motion capture system. METHODS: An open label study was conducted in 30 Japanese subjects with knee pain. The subjects were administered a daily supplement containing 1,200 mg of glucosamine hydrochloride, 60 mg of chondroitin sulfate, 45 mg of type II collagen peptides, 90 mg of quercetin glycosides, 10 mg of imidazole peptides, 1 mg of proteoglycan, and 5 μg of vitamin D (GCQID)...
2016: Clinical Interventions in Aging
Elizabeth D Kantor, Xuehong Zhang, Kana Wu, Lisa B Signorello, Andrew T Chan, Charles S Fuchs, Edward L Giovannucci
Recent epidemiologic evidence has emerged to suggest that use of glucosamine and chondroitin supplements may be associated with reduced risk of colorectal cancer (CRC). We therefore evaluated the association between use of these non-vitamin, non-mineral supplements and risk of CRC in two prospective cohorts, the Nurses' Health Study and Health Professionals Follow-up Study. Regular use of glucosamine and chondroitin was first assessed in 2002 and participants were followed until 2010, over which time 672 CRC cases occurred...
November 1, 2016: International Journal of Cancer. Journal International du Cancer
Federico Fusini, Salvatore Bisicchia, Carlo Bottegoni, Antonio Gigante, Fabio Zanchini, Alberto Busilacchi
BACKGROUND: nutraceuticals are common support therapy for management of tendinopathies. Even if they are widely diffused, our knowledge is still poor. The aim of this systematic review is to analyze the most commonly used nutraceuticals and their effects on tendons. METHODS: glucosamine and chondroitin sulphate, vitamin C, hydrolazed type 1 collagen, arginine alpha-keto-glutarate, bromelain, curcumin, boswellic acid, and methil-sulfonil-methane were considered. During the last week of Dicember 2015 a comprehensive research of main databases for each substance was made in relation with tendinopathy...
January 2016: Muscles, Ligaments and Tendons Journal
Allen F Shaughnessy
No abstract text is available yet for this article.
June 15, 2016: American Family Physician
Priscila Marconcin, Margarida Espanha, Flávia Yázigi, Pedro Campos
BACKGROUND: International recommendations suggest exercise and self-management programs, including non-pharmacological treatments, for knee osteoarthritis (KOA) because they can benefit pain relief and improve function and exercise adherence. The implementation of a combined self-management and exercise program termed PLE(2)NO may be a good method for controlling KOA symptoms because it encourages the development of self-efficacy to manage the pathology. This study will assess the effects of a self-management and exercise program in comparison to an educational intervention (control program) on symptoms, physical fitness, health-related quality of life, self-management behaviors, self-efficacy, physical activity level and coping strategies...
2016: BMC Musculoskeletal Disorders
Mamta Bishnoi, Ankit Jain, Pooja Hurkat, Sanjay K Jain
Chondroitin sulfate (CS) being a natural glycosaminoglycan is found in the cartilage and extracellular matrix. It shows clinical benefits in symptomatic osteoarthritis (OA) of the finger, knee, hip joints, low back, facial joints and other diseases due to its anti-inflammatory activity. It also helps in OA by providing resistance to compression, maintaining the structural integrity, homeostasis, slows breakdown and reduces pain in sore muscles. It is most often used in combination with glucosamine to treat OA...
October 2016: Glycoconjugate Journal
María Carmen Terencio, María Luisa Ferrándiz, María Carmen Carceller, Ramón Ruhí, Pere Dalmau, Josep Vergés, Eulàlia Montell, Anna Torrent, María José Alcaraz
CONTEXT: The efficacy of the combination chondroitin sulfate-glucosamine (CS-GlcN) in the treatment of knee osteoarthritis (OA) has been suggested in recent clinical studies. In vitro reports have also suggested anti-inflammatory and anti-resorptive effects of this combination. OBJECTIVE: The aim of this study was to characterize the effects of CS-GlcN on joint degradation in vivo including the assessment of inflammation and bone metabolism in a model of OA. MATERIALS AND METHODS: We have used the OA model induced by anterior cruciate ligament transection (ACLT) in ovariectomised rats...
April 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nimal Fernando, Elke Wu, Cissy Kou, Paolo Martelli, Lee Foo Khong, Kathy Larson
In 2002 a 23-yr-old female giant panda (Ailuropoda melanoleuca) presented with left hind limb lameness presumably due to osteoarthritis. For the next five years, arthritic episodes were managed with the nonsteroidal anti-inflammatory drug (NSAID) carprofen at 2 mg/kg p.o. s.i.d., then reduced to 1 mg/kg p.o. s.i.d. and withdrawn. Radiographs revealed osteoarthritis in various joints and lumbar spondylosis. In 2007 glucosamine and chondroitin at 1.65 g p.o. b.i.d. and a polyunsaturated fatty acid at 1 capsule p...
March 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Veronica Mantovani, Francesca Maccari, Nicola Volpi
Osteoarthritis is a disabling affliction expected to increase in the coming decades, and disease- modifying osteoarthritis drugs (DMOADs) would be highly desirable adjuncts to symptomatic relief and structure reconstruction as they may delay the disease process. Chondroitin sulfate and glucosamine have been observed to exert beneficial effects on the metabolism of various cells involved in osteoarthritis as well as in animal models and clinical trials. Clinical trials have reported beneficial effects of both these biological agents, alone or in combination, on pain and functions as well as their structure-modifying capacity reported and analyzed in recent meta-analyses...
2016: Current Medicinal Chemistry
S S Rodionova, N A Eskin
The analysis of the dynamics of pain and joint function on the background of the 3-month ARTRA.Study was conducted as a multicenter, with the inclusion of 3077 patients, 56.2% of whom received NSAIDs for pain relief. While taking after a month of therapy showed significant compared to the original value of reducing the intensity of pain. The therapeutic effect is increased with duration of dosing. It is shown that the drug reduces the need for arthritis NSAIDs after a month by 6.8%, after 3 months - by 37.3%, ie after the 3-month course of treatment with arthritis, the number of people taking NSAIDs fell by more than 3 times (up 18...
2016: Khirurgiia
Cécile Bascoul-Colombo, Iveta Garaiova, Sue F Plummer, John L Harwood, Bruce Caterson, Clare E Hughes
OBJECTIVE: Glucosamine hydrochloride (GH) and chondroitin sulfate (CS) are commonly used for the treatment of osteoarthritis (OA). The aim of this study was to assess their effects, alone and in combination, on preventing aggrecan degradation and inflammation in an in vitro model of OA. DESIGN: To test the effects of GH and/or CS as a preventative treatment, cartilage explants were pretreated with the compound(s) using concentrations that showed no detrimental effect on chondrocyte viability...
January 2016: Cartilage
Chong-Zhi Wang, Jonathan Moss, Chun-Su Yuan
BACKGROUND: Patients who undergo surgery appear to use dietary supplements significantly more frequently than the general population. Because they contain pharmacologically active compounds, dietary supplements may affect coagulation and platelet function during the perioperative period through direct effects, pharmacodynamic interactions, and pharmacokinetic interactions. However, in this regard, limited studies have been conducted that address the pharmacological interactions of dietary supplements...
September 2015: Medicines (Basel, Switzerland)
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