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Glucosamine AND chondroitin

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https://www.readbyqxmd.com/read/29771395/glucosamine-and-chondroitin-sulfate-what-has-been-learned-since-the-glucosamine-chondroitin-arthritis-intervention-trial
#1
Nicholas DiNubile
Glucosamine and chondroitin sulfate, alone or in combination, are used worldwide by individuals suffering from osteoarthritis pain. They are by prescription in some countries but are available as over-the-counter dietary supplements in other countries, such as the United States. The inconclusive results of the National Institutes of Health-sponsored Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) did little to clarify the efficacy of these agents. However, some newer studies have provided a better perspective on the potential benefits that they can offer...
May 16, 2018: Orthopedics
https://www.readbyqxmd.com/read/29713967/effects-of-glucosamine-in-patients-with-osteoarthritis-of-the-knee-a-systematic-review-and-meta-analysis
#2
Toru Ogata, Yuki Ideno, Masami Akai, Atsushi Seichi, Hiroshi Hagino, Tsutomu Iwaya, Toru Doi, Keiko Yamada, Ai-Zhen Chen, Yingzi Li, Kunihiko Hayashi
Osteoarthritis (OA) of the knee is one of the main causes of mobility decline in the elderly. Non-surgical treatments such as administration of supplements to strengthen the joint cartilage matrix have become popular not only for pain relief but also for joint preservation. Glucosamine has been used in many countries based on the increasing evidence of its effectiveness for OA. Although there are many previous studies and systematic reviews, the findings vary and different conclusions have been drawn. We aimed to review recent randomized controlled trials on glucosamine for knee OA to reveal up-to-date findings about this supplement...
April 30, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29701488/effectiveness-of-a-dietary-supplement-containing-hydrolyzed-collagen-chondroitin-sulfate-and-glucosamine-in-pain-reduction-and-functional-capacity-in-osteoarthritis-patients
#3
Jordi Puigdellivol, Carme Comellas Berenger, Miguel Ángel Pérez Fernández, Juan M Cowalinsky Millán, Christian Carreras Vidal, Inés Gil Gil, Julio Martínez Pagán, Borja Ruiz Nieto, Francisco Jiménez Gómez, Francesc X Comas Figuerola, María E Aguilar Hernández
This observational, open, multicenter clinical trial with a single treatment group aimed to evaluate the effectiveness of a dietary supplement whose main ingredients are hydrolyzed gelatin, chondroitin sulfate, glucosamine sulfate, and devil's claw and bamboo extracts for pain reduction and improvement of functional capacities in patients with osteoarthritis (OA) of the knee and/or hip (REDART study). In all, 130 patients with OA recruited from Spanish hospitals received the dietary supplement for 6 months...
April 27, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29595285/-nutraceuticals-in-therapy-of-knee-osteoarthritis-orthopaedic-view
#4
Jiří Gallo
Knee osteoarthritis is one of the most frequent diagnoses of load-carrying joints encountered in orthopaedic surgeons offices. Depending on the clinical stage, the therapy starts with conservative treatment. Corrective osteotomy is indicated in younger patients without an extensive and serious impairment. Implantation of TKR (total knee replacement) is usually indicated in more advanced stages. One of the pillars of conservative therapy is analgesics and non-steroidal antirheumatic drugs. A specific group consists of perorally administered drugs for suppression of symptoms or even deceleration of knee osteoarthrosis...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29564812/negative-electron-transfer-dissociation-sequencing-of-3-o-sulfation-containing-heparan-sulfate-oligosaccharides
#5
Jiandong Wu, Juan Wei, John D Hogan, Pradeep Chopra, Apoorva Joshi, Weigang Lu, Joshua Klein, Geert-Jan Boons, Cheng Lin, Joseph Zaia
Among dissociation methods, negative electron transfer dissociation (NETD) has been proven the most useful for glycosaminoglycan (GAG) sequencing because it produces informative fragmentation, a low degree of sulfate losses, high sensitivity, and translatability to multiple instrument types. The challenge, however, is to distinguish positional sulfation. In particular, NETD has been reported to fail to differentiate 4-O- versus 6-O-sulfation in chondroitin sulfate decasaccharide. This raised the concern of whether NETD is able to differentiate the rare 3-O-sulfation from predominant 6-O-sulfation in heparan sulfate (HS) oligosaccharides...
March 21, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29525231/effect-of-an-oral-joint-supplement-when-compared-to-carprofen-in-the-management-of-hip-osteoarthritis-in-working-dogs
#6
João Carlos Alves, Ana Margarida Santos, Patrícia Isabel Jorge
The goal of this study was to evaluate the effectiveness of an oral joint supplement in working dogs with hip osteoarthritis compared with a positive control group (CG). Fifteen animals were divided in treatment group (TG, n = 10) and CG (n = 5). To TG a commercially available joint supplement, containing glucosamine HCl, chondroitin sulphate, and hyaluronic acid was given for 40 days and a 70-day course of a placebo, to be administered as if it was carprofen. The CG received carprofen for 70 days, and a placebo to be administered as the joint supplement...
December 2017: Topics in Companion Animal Medicine
https://www.readbyqxmd.com/read/29488228/cytochrome-p450-2c9-natural-antiarthritic-interactions-evaluation-of-inhibition-magnitude-and-prediction-from-in-vitro-data
#7
Boon Hooi Tan, Nafees Ahemad, Yan Pan, Uma Devi Palanisamy, Iekhsan Othman, Beow Chin Yiap, Chin Eng Ong
Many dietary supplements are promoted to patients with osteoarthritis (OA) including the three naturally derived compounds, glucosamine, chondroitin and diacerein. Despite their wide spread use, research on interaction of these antiarthritic compounds with human hepatic cytochrome P450 (CYP) enzymes is limited. This study aimed to examine the modulatory effects of these compounds on CYP2C9, a major CYP isoform, using in vitro biochemical assay and in silico models. Utilizing valsartan hydroxylase assay as probe, all forms of glucosamine and chondroitin exhibited IC50 values beyond 1000 μM, indicating very weak potential in inhibiting CYP2C9...
April 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29465368/comparative-effectiveness-of-glucosamine-chondroitin-acetaminophen-or-celecoxib-for-the-treatment-of-knee-and-or-hip-osteoarthritis-a-network-meta-analysis
#8
Xiaoyue Zhu, Dandong Wu, Lingli Sang, Yidan Wang, Yi Shen, Xun Zhuang, Minjie Chu, Liying Jiang
OBJECTIVES: To compare the efficacies of oral glucosamine, chondroitin, the combination of glucosamine and chondroitin, acetaminophen and celecoxib on the treatment of knee and/or hip osteoarthritis. METHODS: We searched electronic databases including PubMed, Embase, and Cochrane Library and the reference lists of relevant articles published from inception to October 23, 2017. A Bayesian hierarchical random effects model was used to examine the overall effect size among mixed multiple interventions...
January 31, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29398161/analgesic-use-and-risk-for-acute-coronary-events-in-patients-with-osteoarthritis-a-population-based-nested-case-control-study
#9
Caridad Pontes, Josep Ramon Marsal, Josep Maria Elorza, Maria Aragón, Daniel Prieto-Alhambra, Rosa Morros
PURPOSE: Recent controversies on the safety profiles of opioids and paracetamol (acetaminophen) have led to changes in clinical guidance on osteoarthritis (OA) management. We studied the existing association between the use of different OA drug therapies and the risk for acute coronary events. METHODS: A cohort of patients with clinically diagnosed OA (according to ICD-10 codes) was identified in the SIDIAP database. Within the cohort, cases with incident acute coronary events (acute myocardial infarction or unstable angina) between 2008 and 2012 were identified using ICD-10 codes and data from hospital admission...
February 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29391578/possible-role-of-chondroitin-sulphate-and-glucosamine-for-primary-prevention-of-colorectal-cancer-results-from-the-mcc-spain-study
#10
Gemma Ibáñez-Sanz, Anna Díez-Villanueva, Laura Vilorio-Marqués, Esther Gracia, Nuria Aragonés, Rocío Olmedo-Requena, Javier Llorca, Juana Vidán, Pilar Amiano, Pilar Nos, Guillermo Fernández-Tardón, Ricardo Rada, María Dolores Chirlaque, Elisabet Guinó, Verónica Dávila-Batista, Gemma Castaño-Vinyals, Beatriz Pérez-Gómez, Benito Mirón-Pozo, Trinidad Dierssen-Sotos, Jaione Etxeberria, Amaia Molinuevo, Begoña Álvarez-Cuenllas, Manolis Kogevinas, Marina Pollán, Victor Moreno
A safe and effective colorectal cancer (CRC) chemoprevention agent remains to be discovered. We aim to evaluate the association between the use of glucosamine and/or chondroitin sulphate and risk of colorectal cancer (CRC) in the MCC-Spain study, a case-control study performed in Spain that included 2140 cases of CRC and 3950 population controls. Subjects were interviewed on sociodemographic factors, lifestyle, family and medical history and regular drug use. Adjusted odds ratios and their 95% confidence intervals were estimated...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29359666/enhancing-the-intestinal-permeation-of-the-chondroprotective-nutraceuticals-glucosamine-sulphate-and-chondroitin-sulphate-using-conventional-and-modified-liposomes
#11
Ahmed M Agiba, Maha Nasr, Sameh Abdel-Hamid, Ahmed B Eldin, Ahmed S Geneidi
Liposomes are promising systems for the delivery of macromolecules and poorly absorbed drugs, owing to their ability to compartmentalize drugs, their biodegradability and biocompatibility. The aim of the present study was to formulate and evaluate conventional and modified glucosamine sulphate (GluS) and chondroitin sulphate (CS) liposomal formulations, to enhance their oral permeation for treatment of osteoarthritis (OA). Liposomal formulations were prepared by the thin-film hydration method using two types of phospholipids; Epikuron 200© and Epikuron 200© SH, and three permeation enhancers; poloxamer 407, cetylpyridinium chloride, and sodium deoxycholate...
January 22, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29341524/-what-s-new-in-ambulatory-general-internal-medicine%C3%A2
#12
Annick Gerber, Camille Buffle Genecand, Thierry Mach, David Schrumpf, Ana Rita Forte Marques, Jean Dupraz, Thomas Schmid
Many treatments are used every day in general medicine without any evidence of their efficacy. This last year, three randomised studies tried to prove the clinical utility of chondroitin/glucosamine in arthritis, cranberry in urinary infections, and acupuncture in migraine. Screening and management of prostate cancer are still controversial. Two recent studies help us advising our patients on this difficult topic. Muscle side effects from statins are well known and have been widely relayed by the press these last years, although myopathies are rare in clinical trials...
January 17, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29196833/chondroitin-sulfate-and-glucosamine-sulfate-associated-to-photobiomodulation-prevents-degenerative-morphological-changes-in-an-experimental-model-of-osteoarthritis-in-rats
#13
Marcella Sanches, Lívia Assis, Cyntia Criniti, Danilo Fernandes, Carla Tim, Ana Claudia Muniz Renno
The aim of this study was to compare the effects of combined treatment with chondroitin sulfate and glucosamine sulfate (CS/Gl) and photobiomodulation (PBM) on the degenerative process related to osteoarthritis (OA) in the articular cartilage in rats. Forty male Wistar rats were randomly divided into four groups: OA control group (CG); OA animals submitted to PBM treatment (PBM); OA animals submitted to CS/Gl treatment (CS/Gl); OA submitted to CS/GS associated with PBM treatments (GS/Gl + PBM). The CS/Gl started 48 h after the surgery, and they were performed for 29 consecutive days...
December 1, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29177637/inappropriate-claims-from-non-equivalent-medications-in-osteoarthritis-a-position-paper-endorsed-by-the-european-society-for-clinical-and-economic-aspects-of-osteoporosis-osteoarthritis-and-musculoskeletal-diseases-esceo
#14
REVIEW
Olivier Bruyère, Cyrus Cooper, Nasser M Al-Daghri, Elaine M Dennison, René Rizzoli, Jean-Yves Reginster
Osteoarthritis (OA) is a progressive joint disease, that occurs frequently in the aging population and is a major cause of disability worldwide. Both glucosamine and chondroitin are biologically active molecules that are substrates for proteoglycan, an essential component of the cartilage matrix. Evidence supports the use of glucosamine and chondroitin as symptomatic slow-acting drugs for osteoarthritis (SYSADOAs) with impact on OA symptoms and disease-modifying effects in the long term. Glucosamine and chondroitin are administered in exogenous form as a sulfate salt and multiple formulations of these agents are available, both as prescription-grade products and nutritional supplements...
February 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29171489/-melatonin-in-the-treatment-of-low-back-pain-and-predictors-of-its-efficacy
#15
Yu M Kurganova, A B Danilov
AIM: To assess analgesic properties of melatonin in the treatment of chronic non-specific low back pain and to study predictors of its efficacy. MATERIAL AND METHODS: A study included 178 patients, aged from 40 to 65 years, with chronic non-specific low back pain during >3 month and the VAS score >3. Patients were stratified into 6 groups (3 pairs of comparison). In the first pair, patients of both groups received a combination of 500 mg of glucosamine hydrochloride and 500 mg of chondroitin sulfate; in the second pair - a combination of 500 mg of glucosamine hydrochloride and 500 mg of chondroitin sulfate and diclofenac, in the third pair - diclofenac...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29154065/does-nurses-role-health-or-symptoms-influence-their-personal-use-of-ingestible-complementary-and-alternative-medicines
#16
Sofia Dimitrelis, Lin Perry, Robyn Gallagher, Christine Duffield, David Sibbritt, Rachel Nicholls, Xiaoyue Xu
OBJECTIVES: To investigate the influence of work-related characteristics, health, health behaviours and symptoms on ingestible biologically-based Complementary and Alternative Medicine (CAM) use within the Australian nursing and midwifery workforce. BACKGROUND: CAM use is widespread worldwide, but there is little research into nurses' and midwives' personal use of ingestible CAM in Australia. METHODS: An online survey in 2014-15 used validated instruments and items to examine use of ingestible biologically-based CAM (herbs, foods and vitamins, minerals, amino acids, enzymes and other supplements), and the health and work-related characteristics of 5041 nurses and midwives recruited through the New South Wales Nurses and Midwives Association and professional networks...
December 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/29152248/nutritional-management-of-search-and-rescue-dogs
#17
G Vassalotti, N Musco, P Lombardi, S Calabrò, R Tudisco, V Mastellone, R Grazioli, S Bianchi, M I Cutrignelli
Dogs used for search and rescue (SAR) may experience continuous micro-traumas that predispose them to skeletal disorders. The aim of the present study was to evaluate the effect of diet on osteo-articular apparatus in healthy SAR dogs. A total of sixteen SAR dogs were divided into two groups (low supplementation (LS) and high supplementation (HS)) and were fed for 3 months with two experimental diets, characterised by the same protein and energy density, but different in n -3 PUFA (6·2 v . 8·4 % of metabolisable energy), chondroitin sulfate (219·8 v ...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29119193/outpatient-management-of-knee-osteoarthritis
#18
Yiyang Liow, Wilson Wang, Victor Weng Keong Loh
Osteoarthritis of the knee is a common disease that causes significant disability. Most patients can be managed conservatively in the outpatient setting. A small minority require surgery. The cornerstones of treatment are weight loss, exercise and analgesia. Walking aids, medial patellar taping, acupuncture and transcutaneous electrical nerve stimulation are useful management adjuncts. Current evidence does not support routine prescription of glucosamine and chondroitin supplements. Early consultation with an orthopaedic surgeon should be made when conservative measures fail...
October 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/29050433/effect-of-the-addition-of-glycosaminoglycans-on-bone-and-cartilaginous-development-of-broiler-chickens
#19
Sarah Sgavioli, Elaine T Santos, Liliana L Borges, Giuliana M Andrade-Garcia, Diana M C Castiblanco, Vitor R Almeida, Rodrigo G Garcia, Antônio C Shimano, Irenilza A Nääs, Silvana M Baraldi-Artoni
Locomotion issues in broiler production may decrease performance (carcass yield and traits) and lead to high financial losses. This study evaluates the addition of glucosaminoglycans in broiler diets to minimize the lack of proper bone development and joint weakening. The experiment was conducted using 2,160 broilers randomly distributed in a factorial pattern (3 × 3) using 3 levels of glucosamine sulfate (0, 0.12, and 0.24%) and 3 levels of chondroitin sulfate addition (0, 0.08, and 0.16%). Eight repetitions were used for each treatment, distributed in 72 pens with 30 broilers each...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29018060/dietary-supplements-for-treating-osteoarthritis-a-systematic-review-and-meta-analysis
#20
REVIEW
Xiaoqian Liu, Gustavo C Machado, Jillian P Eyles, Varshini Ravi, David J Hunter
OBJECTIVE: To investigate the efficacy and safety of dietary supplements for patients with osteoarthritis. DESIGN: An intervention systematic review with random effects meta-analysis and meta-regression. DATA SOURCES: MEDLINE, EMBASE, Cochrane Register of Controlled Trials, Allied and Complementary Medicine and Cumulative Index to Nursing and Allied Health Literature were searched from inception to April 2017. STUDY ELIGIBILITY CRITERIA: Randomised controlled trials comparing oral supplements with placebo for hand, hip or knee osteoarthritis...
February 2018: British Journal of Sports Medicine
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