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https://www.readbyqxmd.com/read/29708262/bipolar-magnetic-semiconductors-among-intermediate-states-during-the-conversion-from-sc-2-c-oh-2-to-sc-2-co-2-mxene
#1
Xian-Hu Zha, Ji-Chang Ren, Li Feng, Xiaojing Bai, Kan Luo, Yaqing Zhang, Jian He, Qing Huang, Joseph S Francisco, Shiyu Du
MXenes represent a new family of two-dimensional materials that have attracted considerable attention in recent years. Because of the remarkably different structures of Sc2C(OH)2 and Sc2CO2 MXene and their recently reported properties, this study explored the structural evolution and mechanism of chemical conversion between these two MXenes. Using first-principles density functional theory (DFT), the mechanism for dehydrogenation/hydrogenation is investigated by gradually removing/adding surface hydrogen atoms for Sc2C(OH)2/Sc2CO2 supercells...
April 30, 2018: Nanoscale
https://www.readbyqxmd.com/read/29605397/venous-thromboembolism-in-children-with-sickle-cell-disease-a-retrospective-cohort-study
#2
Gary M Woods, Ruchika Sharma, Susan Creary, Sarah O'Brien, Joseph Stanek, Kan Hor, Jennifer Young, Amy L Dunn, Riten Kumar
OBJECTIVES: To describe the cumulative incidence of venous thromboembolism (VTE) in children with sickle cell disease (SCD) followed at a single institution and report on the risk factors associated with VTE development. STUDY DESIGN: Charts for all patients with SCD, aged 0-21 years, followed at Nationwide Children's Hospital over a 6-year period (January 1, 2009, to January 31, 2015) were reviewed. Data on VTE diagnosis, sex, body mass index/weight-for-length, SCD genotype, SCD clinical complications, central venous catheter (CVC) placement, and thrombophilia testing were collected...
March 28, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29505866/periodic-benefit-risk-assessment-using-bayesian-stochastic-multi-criteria-acceptability-analysis
#3
Kan Li, Shuai Sammy Yuan, William Wang, Shuyan Sabrina Wan, Paulette Ceesay, Joseph F Heyse, Shahrul Mt-Isa, Sheng Luo
Benefit-risk (BR) assessment is essential to ensure the best decisions are made for a medical product in the clinical development process, regulatory marketing authorization, post-market surveillance, and coverage and reimbursement decisions. One challenge of BR assessment in practice is that the benefit and risk profile may keep evolving while new evidence is accumulating. Regulators and the International Conference on Harmonization (ICH) recommend performing periodic benefit-risk evaluation report (PBRER) through the product's lifecycle...
April 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29490770/-in-vitro-induction-of-t-regulatory-cells-by-a-methylated-cpg-dna-sequence-in-humans-potential-therapeutic-applications-in-allergic-and-autoimmune-diseases
#4
Oliver J Lawless, Joseph A Bellanti, Milton L Brown, Kathryn Sandberg, Jason G Umans, Li Zhou, Weiqian Chen, Julie Wang, Kan Wang, Song Guo Zheng
BACKGROUND: Allergic and autoimmune diseases comprise a group of inflammatory disorders caused by aberrant immune responses in which CD25+ Forkhead box P3-positive (FOXP3+) T regulatory (Treg) cells that normally suppress inflammatory events are often poorly functioning. This has stimulated an intensive investigative effort to find ways of increasing Tregs as a method of therapy for these conditions. One such line of investigation includes the study of how ligation of Toll-like receptors (TLRs) by CpG oligonucleotides (ODN) results in an immunostimulatory cascade that leads to induction of T-helper (Th) type 1 and Treg-type immune responses...
March 1, 2018: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/29478284/immediate-implant-placement-and-provisionalization-of-maxillary-anterior-single-implants
#5
REVIEW
Joseph Yun Kwong Kan, Kitchai Rungcharassaeng, Matteo Deflorian, Tommaso Weinstein, Hom-Lay Wang, Tiziano Testori
An inevitable loss of soft and hard tissue after tooth extraction often results in a compromised site for anterior implant esthetics in both vertical and horizontal dimensions. Immediate implant placement and provisionalization has been a viable option for replacing failing maxillary anterior teeth as it preserves the vertical existing osseous and gingival architecture. With the simultaneous addition of soft- and hard-tissue grafts, the peri-implant horizontal tissue topography can also be maintained. The esthetic success of immediate implant placement and provisionalization procedures is influenced by a number of factors that can be identified as patient-dependent or clinician-dependent...
June 2018: Periodontology 2000
https://www.readbyqxmd.com/read/29431029/oversized-biodegradable-arterial-grafts-promote-enhanced-neointimal-tissue-formation
#6
Cameron A Best, Takuma Fukunishi, Joseph Drews, Ramak Khosravi, Kan Hor, Nathan Mahler, Tai Yi, Jay D Humphrey, Jed Johnson, Christopher K Breuer, Narutoshi Hibino
Most tissue-engineered arterial grafts are complicated by aneurysmal dilation secondary to insufficient neotissue formation after scaffold degradation. The optimal graft would form an organized multi-layered structure with a robust extracellular matrix that could withstand arterial pressure. The purpose of the current study was to determine how oversizing a biodegradable arterial scaffold affects long-term neotissue formation. Size-matched (1.0 mm, n=11) and oversized (1.6 mm, n=9) electrospun polycaprolactone/chitosan scaffolds were implanted as abdominal aortic interposition grafts in Lewis rats...
February 12, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28875998/large-scale-immuno-magnetic-cell-sorting-of-t-cells-based-on-a-self-designed-high-throughput-system-for-potential-clinical-application
#7
Qian Zhang, Ting Yin, Rongrong Xu, Wenjun Gao, Hui Zhao, Joseph G Shapter, Kan Wang, Yulan Shen, Peng Huang, Guo Gao, Yanfeng Wu, Daxiang Cui
In this contribution, we designed four types of immuno-magnetic nanoparticles for separation of different T cells (CD3(+), CD4(+), CD8(+) and CD14(+) T cells), and we established a new large-scale immuno-magnetic cell sorting procedure to achieve an enrichment of particular T cells using our designed auto-IMACS device. This device could achieve recyclable large-scale cell sorting, for which the throughput of the system reached ∼4000 mL and the maximum cell capacity was 4 × 10(10). The collected cells were analyzed by flow cytometry and visual cytology data, and the effective selection rates of CD3(+), CD4(+), CD8(+) and CD14(+) T cells were 79...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28809463/dose-escalated-radiation-therapy-is-associated-with-better-overall-survival-in-patients-with-bone-metastases-from-solid-tumors-a-propensity-score-matched-study
#8
Yung-Chih Chou, Chien-Yu Lin, Ping-Ching Pai, Chen-Kan Tseng, Cheng-En Hsieh, Kai-Ping Chang, Cheng-Lung Hsu, Chun-Ta Liao, Chun-Chieh Wang, Shy-Chyi Chin, Tzu-Chen Yen, Tsung-Ying Ho, Ji-Hong Hong, Kin-Fong Lei, Joseph Tung-Chieh Chang, Ngan-Ming Tsang
We aimed to compare the overall survival (OS) of patients with bone metastases (BM) from solid tumors after standard-dose radiotherapy ([RT]; 30 Gy administered in 10 fractions; EQD2Gy  = 32.5 Gy) and dose-escalated RT (EQD2Gy  > 32.5 Gy). We retrospectively reviewed the clinical charts of 1795 patients (median age, 62.3 years; age range, 18-96 years) with BM from solid tumors who were referred for RT to our institute between 2000 and 2013. These patients were assigned to the standard-dose (n = 1125; 63%) and dose-escalated (n = 670; 37%) RT groups...
September 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28798983/role-of-aqp9-in-transport-of-monomethyselenic-acid-and-selenite
#9
Xiangrong Geng, Joseph McDermott, Joseph Lundgren, Liu Liu, Kan-Jen Tsai, Jian Shen, Zijuan Liu
AQP9 is an aquaglyceroporin with a very broad substrate spectrum. In addition to its orthodox nutrient substrates, AQP9 also transports multiple neutral and ionic arsenic species including arsenic trioxide, monomethylarsenous acid (MAs(III)) and dimethylarsenic acid (DMA(V)). Here we discovered a new group of AQP9 substrates which includes two clinical relevant selenium species. We showed that AQP9 efficiently transports monomethylselenic acid (MSeA) with a preference for acidic pH, which has been demonstrated in Xenopus laevis oocyte following the overexpression of human AQP9...
October 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28717791/residual-root-preparation-%C3%A2-for-socket-shield-procedures-%C3%A2-a-facial-window-approach
#10
Phillip Roe, Joseph Y K Kan, Kitichai Rungcharassaeng
Two common complications that occur following immediate implant placement and provisionalization procedures in the anterior maxilla are changes to the facial periimplant soft tissue levels and the facial contours. To counteract these changes, different techniques and treatments have been recommended. The recently introduced socket-shield technique (SST) appears to be a viable treatment option for stabilizing the facial osseous and gingival architecture; however, preparation of the root fragment can present challenges...
2017: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/28675155/the-m-6-a-pathway-facilitates-sex-determination-in-drosophila
#11
Lijuan Kan, Anya V Grozhik, Jeffrey Vedanayagam, Deepak P Patil, Nan Pang, Kok-Seong Lim, Yi-Chun Huang, Brian Joseph, Ching-Jung Lin, Vladimir Despic, Jian Guo, Dong Yan, Shu Kondo, Wu-Min Deng, Peter C Dedon, Samie R Jaffrey, Eric C Lai
The conserved modification N(6)-methyladenosine (m(6)A) modulates mRNA processing and activity. Here, we establish the Drosophila system to study the m(6)A pathway. We first apply miCLIP to map m(6)A across embryogenesis, characterize its m(6)A 'writer' complex, validate its YTH 'readers' CG6422 and YT521-B, and generate mutants in five m(6)A factors. While m(6)A factors with additional roles in splicing are lethal, m(6)A-specific mutants are viable but present certain developmental and behavioural defects...
July 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28557756/factors-associated-with-provider-burnout-in-the-nicu
#12
Daniel S Tawfik, Ciaran S Phibbs, J Bryan Sexton, Peiyi Kan, Paul J Sharek, Courtney C Nisbet, Joseph Rigdon, Mickey Trockel, Jochen Profit
BACKGROUND: NICUs vary greatly in patient acuity and volume and represent a wide array of organizational structures, but the effect of these differences on NICU providers is unknown. This study sought to test the relation between provider burnout prevalence and organizational factors in California NICUs. METHODS: Provider perceptions of burnout were obtained from 1934 nurse practitioners, physicians, registered nurses, and respiratory therapists in 41 California NICUs via a validated 4-item questionnaire based on the Maslach Burnout Inventory...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28436391/prediction-of-conversion-to-alzheimer-s-disease-with-longitudinal-measures-and-time-to-event-data
#13
Kan Li, Wenyaw Chan, Rachelle S Doody, Joseph Quinn, Sheng Luo
BACKGROUND: Identifying predictors of conversion to Alzheimer's disease (AD) is critically important for AD prevention and targeted treatment. OBJECTIVE: To compare various clinical and biomarker trajectories for tracking progression and predicting conversion from amnestic mild cognitive impairment to probable AD. METHODS: Participants were from the ADNI-1 study. We assessed the ability of 33 longitudinal biomarkers to predict time to AD conversion, accounting for demographic and genetic factors...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28430197/g-quadruplex-organic-frameworks
#14
Yi-Lin Wu, Noah E Horwitz, Kan-Sheng Chen, Diego A Gomez-Gualdron, Norman S Luu, Lin Ma, Timothy C Wang, Mark C Hersam, Joseph T Hupp, Omar K Farha, Randall Q Snurr, Michael R Wasielewski
Two-dimensional covalent organic frameworks often π stack into crystalline solids that allow precise spatial positioning of molecular building blocks. Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-assembly of naphthalene diimide and perylene diimide electron acceptors end-capped with two guanine electron donors into crystalline G-quadruplex-based organic frameworks, wherein the electron donors and acceptors form ordered, segregated π-stacked arrays...
May 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28408086/estimates-and-25-year-trends-of-the-global-burden-of-disease-attributable-to-ambient-air-pollution-an-analysis-of-data-from-the-global-burden-of-diseases-study-2015
#15
Aaron J Cohen, Michael Brauer, Richard Burnett, H Ross Anderson, Joseph Frostad, Kara Estep, Kalpana Balakrishnan, Bert Brunekreef, Lalit Dandona, Rakhi Dandona, Valery Feigin, Greg Freedman, Bryan Hubbell, Amelia Jobling, Haidong Kan, Luke Knibbs, Yang Liu, Randall Martin, Lidia Morawska, C Arden Pope, Hwashin Shin, Kurt Straif, Gavin Shaddick, Matthew Thomas, Rita van Dingenen, Aaron van Donkelaar, Theo Vos, Christopher J L Murray, Mohammad H Forouzanfar
BACKGROUND: Exposure to ambient air pollution increases morbidity and mortality, and is a leading contributor to global disease burden. We explored spatial and temporal trends in mortality and burden of disease attributable to ambient air pollution from 1990 to 2015 at global, regional, and country levels. METHODS: We estimated global population-weighted mean concentrations of particle mass with aerodynamic diameter less than 2·5 μm (PM2·5) and ozone at an approximate 11 km × 11 km resolution with satellite-based estimates, chemical transport models, and ground-level measurements...
May 13, 2017: Lancet
https://www.readbyqxmd.com/read/28402348/accuracy-of-bone-sounding-in-assessing-facial-osseous-gingival-tissue-relationship-in-maxillary-anterior-teeth
#16
Joseph Yk Kan, Yoon Jeong Kim, Kitichai Rungcharassaeng, John C Kois
The aim of this study was to evaluate the accuracy of bone sounding (BS) in assessing the facial osseous-gingival tissue relationship (FOGTR) of failing maxillary anterior teeth. Dental records of patients who received immediate implant placement (IIP) at the maxillary anterior area were screened. Mid-FOGTR prior to extraction (BS), and immediately after flapless extraction (direct bone level [DBL] measurement) were analyzed. A total of 160 patients with 190 maxillary anterior teeth were included. The mean FOGTR obtained from BS and DBL were 3...
May 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28395366/teamwork-in-the-nicu-setting-and-its-association-with-health-care-associated-infections-in-very-low-birth-weight-infants
#17
Jochen Profit, Paul J Sharek, Peiyi Kan, Joseph Rigdon, Manisha Desai, Courtney C Nisbet, Daniel S Tawfik, Eric J Thomas, Henry C Lee, J Bryan Sexton
Background and Objective  Teamwork may affect clinical care in the neonatal intensive care unit (NICU) setting. The objective of this study was to assess teamwork climate across NICUs and to test scale-level and item-level associations with health care-associated infection (HAI) rates in very low-birth-weight (VLBW) infants. Methods  Cross-sectional study of the association between HAI rates, defined as any bacterial or fungal infection during the birth hospitalization, among 6,663 VLBW infants cared for in 44 NICUs between 2010 and 2012...
August 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28368133/10-keys-for-successful-esthetic-zone-single-immediate-implants
#18
Robert A Levine, Jeffrey Ganeles, Luiz Gonzaga, Joseph K Kan, Harry Randel, Chris D Evans, Stephen T Chen
The 10 keys for successful esthetic-zone single immediate implants encapsulate in an evidencebased manner the treatment planning and replacement of single hopeless teeth in the maxillary anterior sextant. These include 2 treatment-planning, 5 surgical, and 3 prosthetic keys, which, collectively, aim to minimize soft- and hard-tissue complications for an optimal esthetic implant restoration. The straightforward, advanced, and complex (SAC) classification was designed to aid clinicians in the treatment planning of dental implant cases...
April 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27470028/estimates-of-global-regional-and-national-incidence-prevalence-and-mortality-of-hiv-1980-2015-the-global-burden-of-disease-study-2015
#19
(no author information available yet)
BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. METHODS: For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes...
August 2016: Lancet HIV
https://www.readbyqxmd.com/read/27092345/immediate-placement-and-provisionalization-of-maxillary-anterior-single-implant-with-guided-bone-regeneration-connective-tissue-graft-and-coronally-positioned-flap-procedures
#20
Tomonori Waki, Joseph Y K Kan
Immediate implant placement and provisionalization in the esthetic zone have been documented with success. The benefit of immediate implant placement and provisionalization is the preservation of papillary mucosa. However, in cases with osseous defects presenting on the facial bony plate, immediate implant placement procedures have resulted in facial gingival recession. Subepithelial connective tissue grafts for immediate implant placement and provisionalization procedures have been reported with a good esthetic outcome...
2016: International Journal of Esthetic Dentistry
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