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https://www.readbyqxmd.com/read/28875998/large-scale-immuno-magnetic-cell-sorting-of-t-cells-based-on-a-self-designed-high-throughput-system-for-potential-clinical-application
#1
Qian Zhang, Ting Yin, Rongrong Xu, Wenjun Gao, Hui Zhao, Joseph G Shapter, Kan Wang, Yulan Shen, Peng Huang, Guo Gao, Yanfeng Wu, Daxiang Cui
In this contribution, we designed four types of immuno-magnetic nanoparticles for separation of different T cells (CD3(+), CD4(+), CD8(+) and CD14(+) T cells), and we established a new large-scale immuno-magnetic cell sorting procedure to achieve an enrichment of particular T cells using our designed auto-IMACS device. This device could achieve recyclable large-scale cell sorting, for which the throughput of the system reached ∼4000 mL and the maximum cell capacity was 4 × 10(10). The collected cells were analyzed by flow cytometry and visual cytology data, and the effective selection rates of CD3(+), CD4(+), CD8(+) and CD14(+) T cells were 79...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28809463/dose-escalated-radiation-therapy-is-associated-with-better-overall-survival-in-patients-with-bone-metastases-from-solid-tumors-a-propensity-score-matched-study
#2
Yung-Chih Chou, Chien-Yu Lin, Ping-Ching Pai, Chen-Kan Tseng, Cheng-En Hsieh, Kai-Ping Chang, Cheng-Lung Hsu, Chun-Ta Liao, Chun-Chieh Wang, Shy-Chyi Chin, Tzu-Chen Yen, Tsung-Ying Ho, Ji-Hong Hong, Kin-Fong Lei, Joseph Tung-Chieh Chang, Ngan-Ming Tsang
We aimed to compare the overall survival (OS) of patients with bone metastases (BM) from solid tumors after standard-dose radiotherapy ([RT]; 30 Gy administered in 10 fractions; EQD2Gy  = 32.5 Gy) and dose-escalated RT (EQD2Gy  > 32.5 Gy). We retrospectively reviewed the clinical charts of 1795 patients (median age, 62.3 years; age range, 18-96 years) with BM from solid tumors who were referred for RT to our institute between 2000 and 2013. These patients were assigned to the standard-dose (n = 1125; 63%) and dose-escalated (n = 670; 37%) RT groups...
September 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28798983/role-of-aqp9-in-transport-of-monomethyselenic-acid-and-selenite
#3
Xiangrong Geng, Joseph McDermott, Joseph Lundgren, Liu Liu, Kan-Jen Tsai, Jian Shen, Zijuan Liu
AQP9 is an aquaglyceroporin with a very broad substrate spectrum. In addition to its orthodox nutrient substrates, AQP9 also transports multiple neutral and ionic arsenic species including arsenic trioxide, monomethylarsenous acid (MAs(III)) and dimethylarsenic acid (DMA(V)). Here we discovered a new group of AQP9 substrates which includes two clinical relevant selenium species. We showed that AQP9 efficiently transports monomethylselenic acid (MSeA) with a preference for acidic pH, which has been demonstrated in Xenopus laevis oocyte following the overexpression of human AQP9...
October 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28717791/residual-root-preparation-%C3%A2-for-socket-shield-procedures-%C3%A2-a-facial-window-approach
#4
Phillip Roe, Joseph Y K Kan, Kitichai Rungcharassaeng
Two common complications that occur following immediate implant placement and provisionalization procedures in the anterior maxilla are changes to the facial periimplant soft tissue levels and the facial contours. To counteract these changes, different techniques and treatments have been recommended. The recently introduced socket-shield technique (SST) appears to be a viable treatment option for stabilizing the facial osseous and gingival architecture; however, preparation of the root fragment can present challenges...
2017: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/28675155/the-m-6-a-pathway-facilitates-sex-determination-in-drosophila
#5
Lijuan Kan, Anya V Grozhik, Jeffrey Vedanayagam, Deepak P Patil, Nan Pang, Kok-Seong Lim, Yi-Chun Huang, Brian Joseph, Ching-Jung Lin, Vladimir Despic, Jian Guo, Dong Yan, Shu Kondo, Wu-Min Deng, Peter C Dedon, Samie R Jaffrey, Eric C Lai
The conserved modification N(6)-methyladenosine (m(6)A) modulates mRNA processing and activity. Here, we establish the Drosophila system to study the m(6)A pathway. We first apply miCLIP to map m(6)A across embryogenesis, characterize its m(6)A 'writer' complex, validate its YTH 'readers' CG6422 and YT521-B, and generate mutants in five m(6)A factors. While m(6)A factors with additional roles in splicing are lethal, m(6)A-specific mutants are viable but present certain developmental and behavioural defects...
July 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28557756/factors-associated-with-provider-burnout-in-the-nicu
#6
Daniel S Tawfik, Ciaran S Phibbs, J Bryan Sexton, Peiyi Kan, Paul J Sharek, Courtney C Nisbet, Joseph Rigdon, Mickey Trockel, Jochen Profit
BACKGROUND: NICUs vary greatly in patient acuity and volume and represent a wide array of organizational structures, but the effect of these differences on NICU providers is unknown. This study sought to test the relation between provider burnout prevalence and organizational factors in California NICUs. METHODS: Provider perceptions of burnout were obtained from 1934 nurse practitioners, physicians, registered nurses, and respiratory therapists in 41 California NICUs via a validated 4-item questionnaire based on the Maslach Burnout Inventory...
May 2017: Pediatrics
https://www.readbyqxmd.com/read/28436391/prediction-of-conversion-to-alzheimer-s-disease-with-longitudinal-measures-and-time-to-event-data
#7
Kan Li, Wenyaw Chan, Rachelle S Doody, Joseph Quinn, Sheng Luo
BACKGROUND: Identifying predictors of conversion to Alzheimer's disease (AD) is critically important for AD prevention and targeted treatment. OBJECTIVE: To compare various clinical and biomarker trajectories for tracking progression and predicting conversion from amnestic mild cognitive impairment to probable AD. METHODS: Participants were from the ADNI-1 study. We assessed the ability of 33 longitudinal biomarkers to predict time to AD conversion, accounting for demographic and genetic factors...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28430197/g-quadruplex-organic-frameworks
#8
Yi-Lin Wu, Noah E Horwitz, Kan-Sheng Chen, Diego A Gomez-Gualdron, Norman S Luu, Lin Ma, Timothy C Wang, Mark C Hersam, Joseph T Hupp, Omar K Farha, Randall Q Snurr, Michael R Wasielewski
Two-dimensional covalent organic frameworks often π stack into crystalline solids that allow precise spatial positioning of molecular building blocks. Inspired by the hydrogen-bonded G-quadruplexes found frequently in guanine-rich DNA, here we show that this structural motif can be exploited to guide the self-assembly of naphthalene diimide and perylene diimide electron acceptors end-capped with two guanine electron donors into crystalline G-quadruplex-based organic frameworks, wherein the electron donors and acceptors form ordered, segregated π-stacked arrays...
May 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28408086/estimates-and-25-year-trends-of-the-global-burden-of-disease-attributable-to-ambient-air-pollution-an-analysis-of-data-from-the-global-burden-of-diseases-study-2015
#9
Aaron J Cohen, Michael Brauer, Richard Burnett, H Ross Anderson, Joseph Frostad, Kara Estep, Kalpana Balakrishnan, Bert Brunekreef, Lalit Dandona, Rakhi Dandona, Valery Feigin, Greg Freedman, Bryan Hubbell, Amelia Jobling, Haidong Kan, Luke Knibbs, Yang Liu, Randall Martin, Lidia Morawska, C Arden Pope, Hwashin Shin, Kurt Straif, Gavin Shaddick, Matthew Thomas, Rita van Dingenen, Aaron van Donkelaar, Theo Vos, Christopher J L Murray, Mohammad H Forouzanfar
BACKGROUND: Exposure to ambient air pollution increases morbidity and mortality, and is a leading contributor to global disease burden. We explored spatial and temporal trends in mortality and burden of disease attributable to ambient air pollution from 1990 to 2015 at global, regional, and country levels. METHODS: We estimated global population-weighted mean concentrations of particle mass with aerodynamic diameter less than 2·5 μm (PM2·5) and ozone at an approximate 11 km × 11 km resolution with satellite-based estimates, chemical transport models, and ground-level measurements...
May 13, 2017: Lancet
https://www.readbyqxmd.com/read/28402348/accuracy-of-bone-sounding-in-assessing-facial-osseous-gingival-tissue-relationship-in-maxillary-anterior-teeth
#10
Joseph Yk Kan, Yoon Jeong Kim, Kitichai Rungcharassaeng, John C Kois
The aim of this study was to evaluate the accuracy of bone sounding (BS) in assessing the facial osseous-gingival tissue relationship (FOGTR) of failing maxillary anterior teeth. Dental records of patients who received immediate implant placement (IIP) at the maxillary anterior area were screened. Mid-FOGTR prior to extraction (BS), and immediately after flapless extraction (direct bone level [DBL] measurement) were analyzed. A total of 160 patients with 190 maxillary anterior teeth were included. The mean FOGTR obtained from BS and DBL were 3...
May 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/28395366/teamwork-in-the-nicu-setting-and-its-association-with-health-care-associated-infections-in-very-low-birth-weight-infants
#11
Jochen Profit, Paul J Sharek, Peiyi Kan, Joseph Rigdon, Manisha Desai, Courtney C Nisbet, Daniel S Tawfik, Eric J Thomas, Henry C Lee, J Bryan Sexton
Background and Objective Teamwork may affect clinical care in the neonatal intensive care unit (NICU) setting. The objective of this study was to assess teamwork climate across NICUs and to test scale-level and item-level associations with health care-associated infection (HAI) rates in very low-birth-weight (VLBW) infants. Methods Cross-sectional study of the association between HAI rates, defined as any bacterial or fungal infection during the birth hospitalization, among 6,663 VLBW infants cared for in 44 NICUs between 2010 and 2012...
August 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28368133/10-keys-for-successful-esthetic-zone-single-immediate-implants
#12
Robert A Levine, Jeffrey Ganeles, Luiz Gonzaga, Joseph K Kan, Harry Randel, Chris D Evans, Stephen T Chen
The 10 keys for successful esthetic-zone single immediate implants encapsulate in an evidencebased manner the treatment planning and replacement of single hopeless teeth in the maxillary anterior sextant. These include 2 treatment-planning, 5 surgical, and 3 prosthetic keys, which, collectively, aim to minimize soft- and hard-tissue complications for an optimal esthetic implant restoration. The straightforward, advanced, and complex (SAC) classification was designed to aid clinicians in the treatment planning of dental implant cases...
April 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/27470028/estimates-of-global-regional-and-national-incidence-prevalence-and-mortality-of-hiv-1980-2015-the-global-burden-of-disease-study-2015
#13
Haidong Wang, Tim M Wolock, Austin Carter, Grant Nguyen, Hmwe Hmwe Kyu, Emmanuela Gakidou, Simon I Hay, Edward J Mills, Adam Trickey, William Msemburi, Matthew M Coates, Meghan D Mooney, Maya S Fraser, Amber Sligar, Joshua Salomon, Heidi J Larson, Joseph Friedman, Amanuel Alemu Abajobir, Kalkidan Hassen Abate, Kaja M Abbas, Mohamed Magdy Abd El Razek, Foad Abd-Allah, Abdishakur M Abdulle, Semaw Ferede Abera, Ibrahim Abubakar, Laith J Abu-Raddad, Niveen M E Abu-Rmeileh, Gebre Yitayih Abyu, Akindele Olupelumi Adebiyi, Isaac Akinkunmi Adedeji, Ademola Lukman Adelekan, Koranteng Adofo, Arsène Kouablan Adou, Oluremi N Ajala, Tomi F Akinyemiju, Nadia Akseer, Faris Hasan Al Lami, Ziyad Al-Aly, Khurshid Alam, Noore K M Alam, Deena Alasfoor, Saleh Fahed S Aldhahri, Robert William Aldridge, Miguel Angel Alegretti, Alicia V Aleman, Zewdie Aderaw Alemu, Rafael Alfonso-Cristancho, Raghib Ali, Ala'a Alkerwi, François Alla, Rajaa Mohammad, Salem Al-Raddadi, Ubai Alsharif, Elena Alvarez, Nelson Alvis-Guzman, Azmeraw T Amare, Alemayehu Amberbir, Adeladza Kofi Amegah, Walid Ammar, Stephen Marc Amrock, Carl Abelardo T Antonio, Palwasha Anwari, Johan Ärnlöv, Al Artaman, Hamid Asayesh, Rana Jawad Asghar, Reza Assadi, Suleman Atique, Lydia S Atkins, Euripide Frinel G Arthur Avokpaho, Ashish Awasthi, Beatriz Paulina Ayala Quintanilla, Umar Bacha, Alaa Badawi, Aleksandra Barac, Till Bärnighausen, Arindam Basu, Tigist Assefa Bayou, Yibeltal Tebekaw Bayou, Shahrzad Bazargan-Hejazi, Justin Beardsley, Neeraj Bedi, Derrick A Bennett, Isabela M Bensenor, Balem Demtsu Betsu, Addisu Shunu Beyene, Eesh Bhatia, Zulfiqar A Bhutta, Sibhatu Biadgilign, Boris Bikbov, Sait Mentes Birlik, Donal Bisanzio, Michael Brainin, Alexandra Brazinova, Nicholas J K Breitborde, Alexandria Brown, Michael Burch, Zahid A Butt, Julio Cesar Campuzano, Rosario Cárdenas, Juan Jesus Carrero, Carlos A Castañeda-Orjuela, Jacqueline Castillo Rivas, Ferrán Catalá-López, Hsing-Yi Chang, Jung-Chen Chang, Laxmikant Chavan, Wanqing Chen, Peggy Pei-Chia Chiang, Mirriam Chibalabala, Vesper Hichilombwe Chisumpa, Jee-Young Jasmine Choi, Devasahayam Jesudas Christopher, Liliana G Ciobanu, Cyrus Cooper, Tukur Dahiru, Solomon Abreha Damtew, Lalit Dandona, Rakhi Dandona, José das Neves, Pieter de Jager, Diego De Leo, Louisa Degenhardt, Robert P Dellavalle, Kebede Deribe, Amare Deribew, Don C Des Jarlais, Samath D Dharmaratne, Eric L Ding, Pratik Pinal Doshi, Tim R Driscoll, Manisha Dubey, Yousef Mohamed Elshrek, Iqbal Elyazar, Aman Yesuf Endries, Sergey Petrovich Ermakov, Babak Eshrati, Alireza Esteghamati, Imad D A Faghmous, Carla Sofia E Sa Farinha, Andre Faro, Maryam S Farvid, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Joao C Fernandes, Florian Fischer, Joseph Robert Ander Fitchett, Nataliya Foigt, Nancy Fullman, Thomas Fürst, Fortuné Gbètoho Gankpé, Teshome Gebre, Amanuel Tesfay Gebremedhin, Alemseged Aregay Gebru, Johanna M Geleijnse, Bradford D Gessner, Peter W Gething, Tsegaye Tewelde Ghiwot, Maurice Giroud, Melkamu Dedefo Gishu, Elizabeth Glaser, Shifalika Goenka, Amador Goodridge, Sameer Vali Gopalani, Atsushi Goto, Harish Chander Gugnani, Mark D C Guimaraes, Rahul Gupta, Rajeev Gupta, Vipin Gupta, Juanita Haagsma, Nima Hafezi-Nejad, Holly Hagan, Gessessew Bugssa Hailu, Randah Ribhi Hamadeh, Samer Hamidi, Mouhanad Hammami, Graeme J Hankey, Yuantao Hao, Hilda L Harb, Sivadasanpillai Harikrishnan, Josep Maria Haro, Kimani M Harun, Rasmus Havmoeller, Mohammad T Hedayati, Ileana Beatriz Heredia-Pi, Hans W Hoek, Masako Horino, Nobuyuki Horita, H Dean Hosgood, Damian G Hoy, Mohamed Hsairi, Guoqing Hu, Hsiang Huang, John J Huang, Kim Moesgaard Iburg, Bulat T Idrisov, Kaire Innos, Veena J Iyer, Kathryn H Jacobsen, Nader Jahanmehr, Mihajlo B Jakovljevic, Mehdi Javanbakht, Achala Upendra Jayatilleke, Panniyammakal Jeemon, Vivekanand Jha, Guohong Jiang, Ying Jiang, Tariku Jibat, Jost B Jonas, Zubair Kabir, Ritul Kamal, Haidong Kan, André Karch, Corine Kakizi Karema, Dimitris Karletsos, Amir Kasaeian, Anil Kaul, Norito Kawakami, Jeanne Françoise Kayibanda, Peter Njenga Keiyoro, Andrew Haddon Kemp, Andre Pascal Kengne, Chandrasekharan Nair Kesavachandran, Yousef Saleh Khader, Ibrahim Khalil, Abdur Rahman Khan, Ejaz Ahmad Khan, Young-Ho Khang, Jagdish Khubchandani, Yun Jin Kim, Yohannes Kinfu, Miia Kivipelto, Yoshihiro Kokubo, Soewarta Kosen, Parvaiz A Koul, Ai Koyanagi, Barthelemy Kuate Defo, Burcu Kucuk Bicer, Veena S Kulkarni, G Anil Kumar, Dharmesh Kumar Lal, Hilton Lam, Jennifer O Lam, Sinead M Langan, Van C Lansingh, Anders Larsson, James Leigh, Ricky Leung, Yongmei Li, Stephen S Lim, Steven E Lipshultz, Shiwei Liu, Belinda K Lloyd, Giancarlo Logroscino, Paulo A Lotufo, Raimundas Lunevicius, Hassan Magdy Abd El Razek, Mahdi Mahdavi, Marek Majdan, Azeem Majeed, Carla Makhlouf, Reza Malekzadeh, Chabila C Mapoma, Wagner Marcenes, Jose Martinez-Raga, Melvin Barrientos Marzan, Felix Masiye, Amanda J Mason-Jones, Bongani M Mayosi, Martin McKee, Peter A Meaney, Man Mohan Mehndiratta, Alemayehu B Mekonnen, Yohannes Adama Melaku, Peter Memiah, Ziad A Memish, Walter Mendoza, Atte Meretoja, Tuomo J Meretoja, Francis Apolinary Mhimbira, Ted R Miller, Joseph Mikesell, Mojde Mirarefin, Karzan Abdulmuhsin Mohammad, Shafiu Mohammed, Ali H Mokdad, Lorenzo Monasta, Maziar Moradi-Lakeh, Rintaro Mori, Ulrich O Mueller, Brighton Murimira, Gudlavalleti Venkata Satyanarayana Murthy, Aliya Naheed, Luigi Naldi, Vinay Nangia, Denis Nash, Haseeb Nawaz, Chakib Nejjari, Frida Namnyak Ngalesoni, Jean de Dieu Ngirabega, Quyen Le Nguyen, Muhammad Imran Nisar, Ole F Norheim, Rosana E Norman, Luke Nyakarahuka, Felix Akpojene Ogbo, In-Hwan Oh, Foluke Adetola Ojelabi, Bolajoko Olubukunola Olusanya, Jacob Olusegun Olusanya, John Nelson Opio, Eyal Oren, Erika Ota, Mahesh Anand Padukudru, Hye-Youn Park, Jae-Hyun Park, Snehal T Patil, Scott B Patten, Vinod K Paul, Katherine Pearson, Emmanuel Kwame Peprah, Claudia C Pereira, Norberto Perico, Konrad Pesudovs, Max Petzold, Michael Robert Phillips, Julian David Pillay, Dietrich Plass, Suzanne Polinder, Farshad Pourmalek, David M Prokop, Mostafa Qorbani, Anwar Rafay, Kazem Rahimi, Vafa Rahimi-Movaghar, Mahfuzar Rahman, Mohammad Hifz Ur Rahman, Sajjad Ur Rahman, Rajesh Kumar Rai, Sasa Rajsic, Usha Ram, Saleem M Rana, Paturi Vishnupriya Rao, Giuseppe Remuzzi, David Rojas-Rueda, Luca Ronfani, Gholamreza Roshandel, Ambuj Roy, George Mugambage Ruhago, Mohammad Yahya Saeedi, Rajesh Sagar, Muhammad Muhammad Saleh, Juan R Sanabria, Itamar S Santos, Rodrigo Sarmiento-Suarez, Benn Sartorius, Monika Sawhney, Aletta E Schutte, David C Schwebel, Soraya Seedat, Sadaf G Sepanlou, Edson E Servan-Mori, Masood Ali Shaikh, Rajesh Sharma, Jun She, Sara Sheikhbahaei, Jiabin Shen, Kenji Shibuya, Hwashin Hyun Shin, Inga Dora Sigfusdottir, Naris Silpakit, Diego Augusto Santos Silva, Dayane Gabriele Alves Silveira, Edgar P Simard, Shireen Sindi, Jasvinder A Singh, Om Prakash Singh, Prashant Kumar Singh, Vegard Skirbekk, Karen Sliwa, Samir Soneji, Reed J D Sorensen, Joan B Soriano, David O Soti, Chandrashekhar T Sreeramareddy, Vasiliki Stathopoulou, Nicholas Steel, Bruno F Sunguya, Soumya Swaminathan, Bryan L Sykes, Rafael Tabarés-Seisdedos, Roberto Tchio Talongwa, Mohammad Tavakkoli, Bineyam Taye, Bemnet Amare Tedla, Tesfaye Tekle, Girma Temam Shifa, Awoke Misganaw Temesgen, Abdullah Sulieman Terkawi, Fisaha Haile Tesfay, Gizachew Assefa Tessema, Kiran Thapa, Alan J Thomson, Andrew L Thorne-Lyman, Ruoyan Tobe-Gai, Roman Topor-Madry, Jeffrey Allen Towbin, Bach Xuan Tran, Zacharie Tsala Dimbuene, Nikolaos Tsilimparis, Abera Kenay Tura, Kingsley Nnanna Ukwaja, Chigozie Jesse Uneke, Olalekan A Uthman, N Venketasubramanian, Sergey K Vladimirov, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Linhong Wang, Elisabete Weiderpass, Robert G Weintraub, Andrea Werdecker, Ronny Westerman, Tissa Wijeratne, James D Wilkinson, Charles Shey Wiysonge, Charles D A Wolfe, Sungho Won, John Q Wong, Gelin Xu, Ajit Kumar Yadav, Bereket Yakob, Ayalnesh Zemene Yalew, Yuichiro Yano, Mehdi Yaseri, Henock Gebremedhin Yebyo, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Chuanhua Yu, Shicheng Yu, Zoubida Zaidi, Maysaa El Sayed Zaki, Hajo Zeeb, Hao Zhang, Yong Zhao, Sanjay Zodpey, Leo Zoeckler, Liesl Joanna Zuhlke, Alan D Lopez, Christopher J L Murray
BACKGROUND: Timely assessment of the burden of HIV/AIDS is essential for policy setting and programme evaluation. In this report from the Global Burden of Disease Study 2015 (GBD 2015), we provide national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015. METHODS: For countries without high-quality vital registration data, we estimated prevalence and incidence with data from antenatal care clinics and population-based seroprevalence surveys, and with assumptions by age and sex on initial CD4 distribution at infection, CD4 progression rates (probability of progression from higher to lower CD4 cell-count category), on and off antiretroviral therapy (ART) mortality, and mortality from all other causes...
August 2016: Lancet HIV
https://www.readbyqxmd.com/read/27092345/immediate-placement-and-provisionalization-of-maxillary-anterior-single-implant-with-guided-bone-regeneration-connective-tissue-graft-and-coronally-positioned-flap-procedures
#14
Tomonori Waki, Joseph Y K Kan
Immediate implant placement and provisionalization in the esthetic zone have been documented with success. The benefit of immediate implant placement and provisionalization is the preservation of papillary mucosa. However, in cases with osseous defects presenting on the facial bony plate, immediate implant placement procedures have resulted in facial gingival recession. Subepithelial connective tissue grafts for immediate implant placement and provisionalization procedures have been reported with a good esthetic outcome...
2016: International Journal of Esthetic Dentistry
https://www.readbyqxmd.com/read/27057838/preoperative-scc-antigen-crp-serum-levels-and-lymph-node-density-in-oral-squamous-cell-carcinoma
#15
Mohamad Adel, Chung-Kan Tsao, Fu-Chan Wei, Huei-Tzu Chien, Chih-Hsiung Lai, Chun-Ta Liao, Hung-Ming Wang, Kang-Hsing Fan, Chung-Jan Kang, Joseph Tung-Chieh Chang, Shiang-Fu Huang
The prognostic significance of squamous cell carcinoma antigen (SCC-Ag) and C-reactive protein (CRP) levels and lymph node density (LND) has been individually recognized in oral squamous cell carcinoma (OSCC). We investigated the relationship between preoperative serum markers (SCC-Ag and CRP) and postoperative prognostic marker (LND) in this study. We retrospectively analyzed 277 OSCC patients who underwent primary curative resection and neck dissection with/or without adjuvant therapy between March 2008 and November 2013...
April 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26962221/antibodies-elicited-by-multiple-envelope-glycoprotein-immunogens-in-primates-neutralize-primary-human-immunodeficiency-viruses-hiv-1-sensitized-by-cd4-mimetic-compounds
#16
Navid Madani, Amy M Princiotto, David Easterhoff, Todd Bradley, Kan Luo, Wilton B Williams, Hua-Xin Liao, M Anthony Moody, Ganesh E Phad, Néstor Vázquez Bernat, Bruno Melillo, Sampa Santra, Amos B Smith, Gunilla B Karlsson Hedestam, Barton Haynes, Joseph Sodroski
UNLABELLED: The human immunodeficiency virus (HIV-1) envelope glycoproteins (Env) mediate virus entry through a series of complex conformational changes triggered by binding to the receptors CD4 and CCR5/CXCR4. Broadly neutralizing antibodies that recognize conserved Env epitopes are thought to be an important component of a protective immune response. However, to date, HIV-1 Env immunogens that elicit broadly neutralizing antibodies have not been identified, creating hurdles for vaccine development...
May 15, 2016: Journal of Virology
https://www.readbyqxmd.com/read/26932122/promising-electron-mobility-and-high-thermal-conductivity-in-sc2ct2-t-f-oh-mxenes
#17
Xian-Hu Zha, Jie Zhou, Yuhong Zhou, Qing Huang, Jian He, Joseph S Francisco, Kan Luo, Shiyu Du
MXenes, the new 2D transition metal carbides and nitrides, have recently attracted extensive attention due to their diverse applications and excellent performances. However, the thermal and electrical properties of most MXene materials are yet to be studied. In this work, we investigate the electrical and thermal properties of semiconducting Sc2CT2 (T = F, OH) MXenes using first-principles calculations. Both of the Sc2CT2 (T = F, OH) MXenes are determined to show excellent carrier mobilities. The electron mobility in the Sc2CF2 MXene is found to be strongly anisotropic at room temperature, with values of 5...
March 21, 2016: Nanoscale
https://www.readbyqxmd.com/read/26903796/restoring-behavior-via-inverse-neurocontroller-in-a-lesioned-cortical-spiking-model-driving-a-virtual-arm
#18
Salvador Dura-Bernal, Kan Li, Samuel A Neymotin, Joseph T Francis, Jose C Principe, William W Lytton
Neural stimulation can be used as a tool to elicit natural sensations or behaviors by modulating neural activity. This can be potentially used to mitigate the damage of brain lesions or neural disorders. However, in order to obtain the optimal stimulation sequences, it is necessary to develop neural control methods, for example by constructing an inverse model of the target system. For real brains, this can be very challenging, and often unfeasible, as it requires repeatedly stimulating the neural system to obtain enough probing data, and depends on an unwarranted assumption of stationarity...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/26811258/overweight-and-obesity-predict-better-overall-survival-rates-in-cancer-patients-with-distant-metastases
#19
Ngan Ming Tsang, Ping Ching Pai, Chi Cheng Chuang, Wen Ching Chuang, Chen Kan Tseng, Kai Ping Chang, Tzu Chen Yen, Jen Der Lin, Joseph Tung Chieh Chang
Recent studies conducted in patients with chronic diseases have reported an inverse association between body mass index (BMI) and mortality. However, the question as to whether BMI may predict prognosis in patients with metastatic cancer remains open. We therefore designed the current retrospective study to investigate the potential association between BMI and overall survival (OS) in patients with distant metastases (DM) and a favorable performance status. Between 2000 and 2012, a total of 4010 cancer patients with DM who required radiotherapy (RT) and had their BMI measured at the initiation of RT were identified...
April 2016: Cancer Medicine
https://www.readbyqxmd.com/read/26450517/huntingtin-differentially-regulates-the-axonal-transport-of-a-sub-set-of-rab-containing-vesicles-in-vivo
#20
Joseph A White, Eric Anderson, Katherine Zimmerman, Kan Hong Zheng, Roza Rouhani, Shermali Gunawardena
Loss of huntingtin (HTT), the Huntington's disease (HD) protein, was previously shown to cause axonal transport defects. Within axons, HTT can associate with kinesin-1 and dynein motors either directly or via accessory proteins for bi-directional movement. However, the composition of the vesicle-motor complex that contains HTT during axonal transport is unknown. Here we analyze the in vivo movement of 16 Rab GTPases within Drosophila larval axons and show that HTT differentially influences the movement of a particular sub-set of these Rab-containing vesicles...
December 20, 2015: Human Molecular Genetics
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"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"