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https://www.readbyqxmd.com/read/28107673/mri-patterns-of-brain-injury-and-neurodevelopmental-outcomes-in-neonates-with-severe-anaemia-at-birth
#1
Begoña Loureiro, Miriam Martinez-Biarge, Francesca Foti, Maria Papadaki, Frances M Cowan, Courtney J Wusthoff
AIMS: To define patterns of brain injury and associated neurodevelopmental outcomes in infants with severe neonatal anaemia. METHODS: We studied 20 infants with severe anaemia at birth (haemoglobin<7g/dL). Clinical details were analysed for causes of anaemia and co-morbidities. All had early brain magnetic resonance imaging (MRI) scans, which were reviewed for injury pattern. Neurodevelopmental outcomes were assessed at a median age of 24months. RESULTS: The aetiology of the anaemia was feto-maternal haemorrhage in 17 and antepartum haemorrhage in 3 infants...
January 17, 2017: Early Human Development
https://www.readbyqxmd.com/read/28107381/in-vivo-two-photon-imaging-of-astrocytes-in-gfap-gfp-transgenic-mice
#2
Dongjun Guo, Jia Zou, Nicholas Rensing, Michael Wong
Astrocytes play important roles in normal brain function and neurological diseases. In vivo two-photon excitation laser scanning microscopy has the potential to reveal rapid, dynamic structural changes in cells in a variety of physiological and pathological conditions. The type of in vivo imaging method has been shown to affect the plasticity of dendritic spines of neurons, but the optimal in vivo imaging methods of astrocytes have not been established. We compared open-skull and thinned-skull imaging methods for two-photon laser microscopy of live astrocytes in neocortex of GFAP-GFP transgenic mice...
2017: PloS One
https://www.readbyqxmd.com/read/28107262/suspected-cerebral-edema-in-diabetic-ketoacidosis-is-there-still-a-role-for-head-ct-in-treatment-decisions
#3
Carmen L Soto-Rivera, Lisa A Asaro, Michael S D Agus, Danielle D DeCourcey
OBJECTIVES: Neurologic deterioration associated with cerebral edema in diabetic ketoacidosis is typically sudden in onset, progresses rapidly, and requires emergent treatment. The utility of brain imaging by head CT in decisions to treat for cerebral edema has not been previously studied. The objective of this study was to describe the characteristics of pediatric patients with diabetic ketoacidosis who develop altered mental status and evaluate the role of head CT in this cohort. DESIGN: Retrospective analysis of clinical, biochemical, and radiologic data...
January 19, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28107213/computed-tomography-in-the-management-of-adrenal-tumors-does-size-still-matter
#4
Saïd C Azoury, Neeraja Nagarajan, Allen Young, Aarti Mathur, Jason D Prescott, Elliot K Fishman, Martha A Zeiger
OBJECTIVE: We sought to evaluate computed tomography (CT) imaging as a predictor of adrenal tumor pathology. METHODS: A retrospective review was conducted of patients who underwent unilateral adrenalectomy for an adrenal mass between January 2005 and July 2015. Tumors were classified as benign, indeterminate, or malignant based on preoperative CT findings. RESULTS: Of 697 patients who underwent unilateral adrenalectomy, 216 met the inclusion criteria...
January 20, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28107184/tunneling-nanotubes-promote-intercellular-mitochondria-transfer-followed-by-increased-invasiveness-in-bladder-cancer-cells
#5
Jinjin Lu, Xiufen Zheng, Fan Li, Yang Yu, Zhong Chen, Zheng Liu, Zhihua Wang, Hua Xu, Weimin Yang
Intercellular transfer of organelles via tunneling nanotubes (TNTs) is a novel means of cell-to-cell communication. Here we demonstrate the existence of TNTs between co-cultured RT4 and T24 bladder cancer cells using light microscopy, fluorescence imaging, and scanning electron microscopy (SEM). Spontaneous unidirectional transfer of mitochondria from T24 to RT4 cells was detected using fluorescence imaging and flow cytometry. The distribution of mitochondria migrated from T24 cells was in good agreement with the original mitochondria in RT4 cells, which may imply mitochondrial fusion...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28107094/dynamic-volume-assessment-of-hepatocellular-carcinoma-in-rat-livers-using-a-clinical-3t-mri-and-novel-segmentation
#6
Lorenzo A Orci, Graziano Oldani, Stephanie Lacotte, Florence Slits, Iris Friedli, Wolfgang Wirth, Christian Toso, Jean-Paul Vallée, Lindsey A Crowe
PURPOSE: In vivo liver cancer research commonly uses rodent models. One of the limitations of such models is the lack of accurate and reproducible endpoints for a dynamic assessment of growing tumor nodules. The aim of this study was to validate a noninvasive, true volume segmentation method using two rat hepatocellular carcinoma (HCC) models, correlating magnetic resonance imaging (MRI) with histological volume measurement, and with blood levels of α-fetoprotein. MATERIALS AND METHODS: We used 3T clinical MRI to quantify tumor volume with follow-up over time...
January 20, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28106942/assessment-of-intracranial-meningioma-associated-calcifications-using-susceptibility-weighted-mri
#7
Lisa C Adams, Sarah M Böker, Yvonne Y Bender, Eva M Fallenberg, Moritz Wagner, Ralph Buchert, Bernd Hamm, Marcus R Makowski
PURPOSE: To determine the diagnostic accuracy of susceptibility-weighted MRI (SW-MRI) for the detection of intracranial meningioma-associated calcifications compared with standard MR sequences, using computed tomography (CT) as a reference standard. MATERIALS AND METHODS: 354 patients, who had received both a CT and a 1.5 Tesla clinical brain MRI with SW-MRI sequences between January 2014 and July 2016, were retrospectively evaluated and 316 patients were included...
January 20, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28106936/whole-brain-vessel-wall-mri-a-parameter-tune-up-solution-to-improve-the-scan-efficiency-of-three-dimensional-variable-flip-angle-turbo-spin-echo
#8
Qi Yang, Zixin Deng, Xiaoming Bi, Shlee S Song, Konrad H Schlick, Nestor R Gonzalez, Debiao Li, Zhaoyang Fan
PURPOSE: To propose and evaluate a parameter tune-up solution to expedite a three-dimensional (3D) variable-flip-angle turbo spin-echo (TSE) sequence for whole-brain intracranial vessel wall (IVW) imaging. MATERIALS AND METHODS: Elliptical k-space sampling and prolonged echo train length (ETL), were used to expedite a 3D variable-flip-angle TSE-based sequence. To compensate for the potential loss in vessel wall signal, optimal combination of prescribed T2 and ETL was experimentally investigated on 22 healthy volunteers at 3 Tesla...
January 20, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28106704/rapid-spontaneously-resolving-acute-subdural-hematoma
#9
Qi Gan, Hexiang Zhao, Hanmei Zhang, Chao You
INTRODUCTION: This study reports a rare patient of a rapid spontaneously resolving acute subdural hematoma. In addition, an analysis of potential clues for the phenomenon is presented with a review of the literature. PATIENT PRESENTATION: A 1-year-and-2-month-old boy fell from a height of approximately 2 m. The patient was in a superficial coma with a Glasgow Coma Scale of 8 when he was transferred to the authors' hospital. Computed tomography revealed the presence of an acute subdural hematoma with a midline shift beyond 1 cm...
January 18, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28106615/metal-artifact-reduction-in-x-ray-computed-tomography-using-computer-aided-design-data-of-implants-as-prior-information
#10
Veikko Ruth, Daniel Kolditz, Christian Steiding, Willi A Kalender
OBJECTIVES: The performance of metal artifact reduction (MAR) methods in x-ray computed tomography (CT) suffers from incorrect identification of metallic implants in the artifact-affected volumetric images. The aim of this study was to investigate potential improvements of state-of-the-art MAR methods by using prior information on geometry and material of the implant. MATERIALS AND METHODS: The influence of a novel prior knowledge-based segmentation (PS) compared with threshold-based segmentation (TS) on 2 MAR methods (linear interpolation [LI] and normalized-MAR [NORMAR]) was investigated...
January 18, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28106569/cerebellar-volume-and-executive-function-in-parkinson-disease-with-and-without-freezing-of-gait
#11
Peter S Myers, Marie E McNeely, Jonathan M Koller, Gammon M Earhart, Meghan C Campbell
BACKGROUND: Freezing of gait (FOG) affects approximately 50% of people with Parkinson Disease (PD), impacting quality of life and placing financial and emotional strain on the individual and caregivers. People with PD and FOG have similar deficits in motor adaptation and cognition as individuals with cerebellar lesions, indicating the cerebellum may play a role in FOG. OBJECTIVE: To examine potential differences in cerebellar volumes and their relationships with cognition between PD with (FOG+) and without FOG (FOG-)...
January 17, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28106532/rotational-scanning-atomic-force-microscopy
#12
Arturas Ulcinas, Šarūnas Vaitekonis
A non-raster scanning technique for atomic force microscopy imaging which combines the rotational and translational motion is presented. The use of rotational motion for the fast scan axis allows to signi���cantly increase the scanning speed while imaging the large area (diameter > 30 ��m). Image reconstruction algorithm and the factors in���uencing the resolution of the technique are discussed. The experimental results show the potential of the rotational scanning technique for high-throughput large area AFM investigation...
January 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28106226/applied-taguchi-method-for-fatigue-testing-of-customized-hip-implant
#13
Mangesh R Dharme, Abhaykumar M Kuthe, Tushar R Deshmukh
PURPOSE: Human activities generate stresses, which vary with time and may result in fatigue failure of the customized hip implant. This study aims to investigate fatigue testing of customized hip implants using the minimum number of experiments by the Taguchi method, for 147 patients. This study was also useful to determine the influential geometrical parameters on the fatigue safety factor of customized hip implants. METHODS: Horizontal offset (HO), vertical offset (VO) and neck shaft angle (NSA) of the hip joint of 147 patients were measured on computed tomography (CT) scanned images...
January 20, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28106185/direct-mapping-of-the-electric-permittivity-of-heterogeneous-non-planar-thin-films-at-gigahertz-frequencies-by-scanning-microwave-microscopy
#14
Maria Chiara Biagi, Giorgio Badino, Rene Fabregas, Georg Gramse, Laura Fumagalli, Gabriel Gomila
We obtained maps of electric permittivity at ∼19 GHz frequencies on non-planar thin film heterogeneous samples by means of combined atomic force-scanning microwave microscopy (AFM-SMM). We show that the electric permittivity maps can be obtained directly from the capacitance images acquired in contact mode, after removing the topographic cross-talk effects. This result demonstrates the possibility of identifying the electric permittivity of different materials in a thin film sample irrespectively of their thickness by just direct imaging and processing...
January 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28106044/root-canal-morphology-and-configuration-of-123-maxillary-second-molars-by-means-of-micro-ct
#15
Thomas Gerhard Wolf, Frank Paqué, Anja-Christin Woop, Brita Willershausen, Benjamín Briseño-Marroquín
The aim of this study was to investigate the root canal configuration, accessory canals and number of main foramina of 123 maxillary second molars by means of micro-computed tomography. The teeth were scanned and reproduced with 3D software imaging. The root canal configuration and number of main foramina were evaluated by means of a four-digit system. The morphological complexity of human maxillary second molars is depicted by the number of accessory and connecting canals. The most frequently observed root canal configurations in the mesiobuccal root were 2-2-2/2 (19...
January 20, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/28106006/fabrication-of-graphene-silicon-layered-heterostructures-by-carbon-penetration-of-silicon-film
#16
Lei Meng, Yeliang Wang, Linfei Li, H-J Gao
A new, easy, in situ technique for fabricating a two-dimensional graphene-silicon layered heterostructure has been developed to meet the demand for integration between graphene and silicon-based microelectronic technology. First, carbon atoms are stored in bulk iridium, and then silicon atoms are deposited onto the Ir(111) surface and annealed. With longer annealing times, the carbon atoms penetrate from the bulk iridium to the top of the silicon and eventually coalesce there into graphene islands. Atomically resolved scanning tunneling microscopy images, high-pass fast Fourier transform treatment and Raman spectroscopy demonstrate that the top graphene layer is intact and continuous, and beneath it is the silicon layer...
January 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28105833/scanning-probe-microscopy-for-nanoscale-electrochemical-imaging
#17
Yasufumi Takahashi, Akichika Kumatani, Hitoshi Shiku, Tomokazu Matsue
No abstract text is available yet for this article.
January 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28105713/whole-remnant-and-maximum-voxel-spect-ct-dosimetry-in-131-i-nai-treatments-of-differentiated-thyroid-cancer
#18
Pablo Mínguez, Glenn Flux, José Genollá, Alejandro Delgado, Emilia Rodeño, Katarina Sjögreen Gleisner
PURPOSE: To investigate the possible differences between SPECT/CT based whole-remnant and maximum-voxel dosimetry in patients receiving radio-iodine ablation treatment of differentiated thyroid cancer (DTC). METHODS: Eighteen DTC patients were administered 1.11 GBq of (131) I-NaI after near-total thyroidectomy and rhTSH stimulation. Two patients had two remnants, so in total dosimetry was performed for 20 sites. Three SPECT/CT scans were performed for each patient at 1, 2, and 3-7 days after administration...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/28105711/a-gate-evaluation-of-the-sources-of-error-in-quantitative-90-y-pet
#19
Jared Strydhorst, Thomas Carlier, Arnaud Dieudonné, Maurizio Conti, Irène Buvat
PURPOSE: Accurate reconstruction of the dose delivered by (90) Y microspheres using a postembolization PET scan would permit the establishment of more accurate dose-response relationships for treatment of hepatocellular carcinoma with (90) Y. However, the quality of the PET data obtained is compromised by several factors, including poor count statistics and a very high random fraction. This work uses Monte Carlo simulations to investigate what impact factors other than low count statistics have on the quantification of(90) Y PET...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/28105469/qin-dawg-validation-of-gradient-nonlinearity-bias-correction-workflow-for-quantitative-diffusion-weighted-imaging-in-multicenter-trials
#20
Dariya I Malyarenko, Lisa J Wilmes, Lori R Arlinghaus, Michael A Jacobs, Wei Huang, Karl G Helmer, Bachir Taouli, Thomas E Yankeelov, David Newitt, Thomas L Chenevert
Previous research has shown that system-dependent gradient nonlinearity (GNL) introduces a significant spatial bias (nonuniformity) in apparent diffusion coefficient (ADC) maps. Here, the feasibility of centralized retrospective system-specific correction of GNL bias for quantitative diffusion-weighted imaging (DWI) in multisite clinical trials is demonstrated across diverse scanners independent of the scanned object. Using corrector maps generated from system characterization by ice-water phantom measurement completed in the previous project phase, GNL bias correction was performed for test ADC measurements from an independent DWI phantom (room temperature agar) at two offset locations in the bore...
December 2016: Tomography: a Journal for Imaging Research
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