Ze Wang, Xiaojun Ren, Yunfeng Li, Ling Qiu, Dongzhou Wang, Annan Liu, Hao Liang, Lei Li, Bai Yang, Andrew K Whittaker, Zhongshan Liu, Shunzi Jin, Quan Lin, Tiejun Wang
Insufficient reactive oxygen species (ROS) production and radioresistance have consistently contributed to the failure of radiotherapy (RT). The development of a biomaterial capable of activating ROS-induced apoptosis and ferroptosis is a potential strategy to enhance RT sensitivity. To achieve precision and high-efficiency RT, the theranostic nanoplatform Au/Cu nanodots (Au/CuNDs) were designed for dual-mode imaging, amplifying ROS generation, and inducing apoptosis-ferroptosis to sensitize RT. A large amount of ROS is derived from three aspects: (1) When exposed to ionizing radiation, Au/CuNDs effectively absorb photons and emit various electrons, which can interact with water to produce ROS...
April 1, 2024: ACS Nano