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Yufu Tang, Yuanyuan Li, Xiaoming Hu, Hui Zhao, Yu Ji, Liang Chen, Wenbo Hu, Wansu Zhang, Xiang Li, Xiaomei Lu, Wei Huang, Quli Fan
Fluorescence imaging in the second near-infrared window (NIR-II) is a new technique that permits visualization of deep anatomical features with unprecedented spatial resolution. Although attractive, effectively suppressing the interference signal of the background is still an enormous challenge for obtaining target-specific NIR-II imaging in the complex and dynamic physiological environment. Herein, dual-pathological-parameter cooperatively activatable NIR-II fluorescence nanoprobes (HISSNPs) are developed whereby hyaluronic acid chains and disulfide bonds act as the "double locks" to lock the fluorescence-quenched aggregation state of the NIR-II fluorescence dyes for performing ultrahigh specific imaging of tumors in vivo...
June 19, 2018: Advanced Materials
Shengping Wen, Yu Su, Rong Wu, Shiwei Zhou, Qianhao Min, Gao-Chao Fan, Li-Ping Jiang, Rong-Bin Song, Jun-Jie Zhu
The accurate therapeutic evaluation for chronic myeloid leukemia (CML) drug is of great importance to minimize side effects and enhance efficacy. Herein, a facile and precise surface-enhanced scattering (SERS) approach based on coupled plasmonic field has been introduced to evaluate the therapeutic outcomes of antileukemia drug through ultrasensitive assay of caspase-3 activity in apoptotic cells. Caspase-3 as an apoptosis indicator could specifically cleave the N-terminus of biotinylated DEVD-peptide (biotin-Gly-Asp-Gly-Asp-Glu-Val-Asp-Gly-Cys) immobilized on the Au nanoparticle-decorated TiO2 nanotube arrays (TiO2 /Au NTAs) substrate...
June 2, 2018: Biosensors & Bioelectronics
Yayun Wu, Zhizhen Chen, Pengfei Zhang, Lihua Zhou, Tao Jiang, Huajie Chen, Ping Gong, Dimiter S Dimitrov, Lintao Cai, Qi Zhao
We developed highly bright and stable far-red emissive AIEdots by using a new kind of click-functional PEG grafted amphiphilic polymer to coat hydrophobic AIE-active polymers (PDFDP). Furthermore, an anti-HER2 recombinant fully human antibody was produced and conjugated on the AIEdots via metal-free click chemistry to fabricate in vivo tumor-targeting nanoprobes.
June 15, 2018: Chemical Communications: Chem Comm
Meijiao Zhang, Shizhu Zang, Guangbo Ge, Lingling Jin, Yi Xin, Huizhen Li, Pingkun Liu, Xudong Hou, Dacheng Hao, Lu Chen, Qi Zhou, Jie Hou
CD22 is an important drug target for the treatment of autoimmune diseases and B cell-derived malignancies. In this study, N-acetylneuraminic acid functionalized quantum dots nanoconjugate was synthesized and used for targeting and fluorescence imaging of CD22 on living cells. The nanoprobe was prepared by conjugating N-acetylneuraminic acid (NANA) on the carboxyl groups modified CdSe/ZnS quantum dots (COOH-QDs) via NHS/EDC mediated esterification. The NANA-QDs nanoprobe showed excellent size distribution, very low cytotoxicity and super fluorescent properties for biological imaging applications...
August 1, 2018: Journal of Biomedical Nanotechnology
Xialian Lei, Renfu Li, Datao Tu, Xiaoying Shang, Yan Liu, Wenwu You, Caixia Sun, Fan Zhang, Xueyuan Chen
Near-infrared (NIR) II luminescence between 1000 and 1700 nm has attracted reviving interest for biosensing due to its unique advantages such as deep-tissue penetration and high spatial resolution. Traditional NIR-II probes such as organic fluorophores usually suffer from poor photostability and potential long-term toxicity. Herein, we report the controlled synthesis of monodisperse NaCeF4 :Er/Yb nanocrystals (NCs) that exhibit intense NIR-II emission upon excitation at 980 nm. Ce3+ in the host lattice was found to enhance the luminescence of Er3+ at 1530 nm with a maximum NIR-II quantum yield of 32...
May 28, 2018: Chemical Science
Li-Jun Xiang, Xiao-Jiao Zhu, Hui-Hui Zhang, Li Yang, Ke-Xue Deng, Ying Liu, Ming-Shan Ye, Long Hu, Xing-Yuan Yang, Hong-Ping Zhou
Multi-modality in vivo bioimaging has great renown for offering more comprehensive information in medical diagnosis and research. Incorporating different bioimaging capabilities into one biocompatible nanoprobe requires an elegant structural design. Considering optical and magnetic properties, X-ray absorption ability, and clinical safety, we prepared a water-soluble and upconverting PSIoAm-modified Sr2Yb0.3Gd0.7F7:Er3+/Tm3+ bio-probe that not only had high photostability and excellent cell membrane permeability, but could also distinguish the four types of cancer cells and normal cells tested within the scope of our study...
June 13, 2018: Nanoscale
Keqin Deng, Xinyan Liu, Chunxiang Li, Haowen Huang
The loading capacity of thionin (Thi) on shortened multi-walled carbon nanotubes (S-MWCNTs) and acidified multi-walled carbon nanotubes (A-MWCNTs) was compared. Two DNA probe fragments were designed for hybridization with microRNA-21 (miR-21), the microRNAs (miRNAs) model analyte. DNA probe 1 (P1) was assembled on Au nanoparticles (AuNPs) modified electrode. MiR-21 was captured by the pre-immobilized P1. A signal nanoprobe was synthesized by loading large amount of Thi on S-MWCNTs with covalently bonded probe 2 (P2)...
May 31, 2018: Biosensors & Bioelectronics
Zhichao Dai, Hua Ma, Lu Tian, Bo Song, Mingqian Tan, Xiuwen Zheng, Jingli Yuan
A dual-modal fluorescence-magnetic resonance imaging technique has gained tremendous attention for its potential in the dawning era of early diagnosis of tumors with high accuracy. In this study, a facile approach has been developed to prepare a tumor-targetable nanoprobe, PTTA-Eu3+-CoFeO-FA nanoparticles, for dual-modal time-gated luminescence (TGL)-magnetic resonance (MR) imaging of tumor cells in vitro and in vivo. The multifunctional nanoprobe was constructed by coating a tumor-targeting molecule, folic acid (FA), and a luminescent Eu3+ complex, PTTA-Eu3+, onto the surface of cobalt/iron oxide (CoFeO) nanoparticles...
June 12, 2018: Nanoscale
Wenwu You, Datao Tu, Wei Zheng, Xiaoying Shang, Xiaorong Song, Shanyong Zhou, Yan Liu, Renfu Li, Xueyuan Chen
Lanthanide (Ln3+)-doped NaREF4 (RE = rare earth) nanocrystals (NCs) are one of the most widely studied upconversion and downshifting luminescent nanoprobes. However, the size and optical performance of the Ln3+-doped NaREF4 NCs produced by the available lab-scale synthesis may vary from batch to batch, which inevitably limits their practical bioapplications. Herein, we report the synthesis of uniform Ln3+-doped NaREF4 NCs via a facile solid-liquid-thermal-decomposition (SLTD) method by directly employing NaHF2 powder as a fluoride and sodium precursor...
June 11, 2018: Nanoscale
Mingfang Ma, Jiefang Sun, Yiqiang Chen, Kai Wen, Zhaopeng Wang, Jianzhong Shen, Suxia Zhang, Yuebin Ke, Zhanhui Wang
Here we report a novel ultrasensitive surface-enhanced Raman scattering (SERS) immunosensor based on the flower-like gold nanoparticles (AuNFs) and magnetic bead separation for homogeneous detection of amantadine (AMD) in chicken just by one-step. The 5, 5'-dithiobis (2-nitrobenzoicacid) (DTNB) modified AuNFs and N-(1-adamantyl) ethylenediamine (AEDA) conjugated denatured BSA (AEDA-dBSA) was used as the SERS nanoprobe. And the capture probe was anti-AMD monoclonal antibody (mAbs)-functionalized magnetic beads (MNBs-mAbs)...
June 6, 2018: Food and Chemical Toxicology
Yinhui Li, Di Xu, Hei-Nga Chan, Chung-Yan Poon, See-Lok Ho, Hung-Wing Li, Man Shing Wong
Senile plaques, the extracellular deposit of amyloid-β (Aβ) peptides, are one of the neuropathological hallmarks found in Alzheimer's disease (AD) brain. The current method of brain imaging of amyloid plaques based on positron emission tomography (PET) is expensive and invasive with low spatial resolution. Thus, the development of sensitive and nonradiative amyloid-β (Aβ)-specific contrast agents is highly important and beneficial to achieve early AD detection, monitor the disease progression, and evaluate the effectiveness of potential AD drugs...
June 7, 2018: Small
Mingwang Li, Yuanyuan Qiu, Chenchen Fan, Kai Cui, Yongming Zhang, Zeyu Xiao
Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surface-enhanced Raman scattering (SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications...
May 2018: Acta Pharmaceutica Sinica. B
Chongmei Sun, Fangzheng Yuan, Huihui Li, Xia Wu
A nanoprobe was developed for the fluorometric determination of the neurotransmitter dopamine (DA). It is based on the synergistic enhancement action of citrate and gold nanoparticles (AuNPs) on the luminescence of Tb(III). AuNPs serve as substrates of surface enhanced fluorescence (SEF). Citrate, in turn, acts as a spacer for the SEF effect, a co-ligand of Tb(III) complex, and a recognizing component for DA. The synergistic action of citrate and AuNPs significantly increases the intrinsic green fluorescence of Tb(III) (best measured at excitation/emission peaks of 300/547 nm)...
June 6, 2018: Mikrochimica Acta
Vesna Živanović, Geo Semini, Michael Laue, Daniela Drescher, Toni Aebischer, Janina Kneipp
We report the direct probing of the molecular composition of Leishmania infected macrophage cells in vitro by surface-enhanced Raman scattering (SERS). The microscopic mapping data indicate local abundance and distribution of molecular species that are very characteristic of the infection, and that are observed here simultaneously. As revealed by electron microscopy, the gold nanoprobes used for SERS microspectrosopy have access to the parasitophorous vacuoles (PV) through the endosomal system. SERS nanoprobes located in the direct proximity to the parasite, in the greater volume of the PV, and in endolysosomal compartments in other cellular regions, respectively, report a characteristic chemical composition for each respective location...
June 5, 2018: Analytical Chemistry
Yan Xing, Jingyi Zhu, Lingzhou Zhao, Zhijuan Xiong, Yujie Li, San Wu, Gitasha Chand, Xiangyang Shi, Jinhua Zhao
Non-invasive imaging of apoptosis in tumors induced by chemotherapy is of great value in the evaluation of therapeutic efficiency. In this study, we report the synthesis, characterization, and utilization of radionuclide technetium-99m (99m Tc)-labeled dendrimer-entrapped gold nanoparticles (Au DENPs) for targeted SPECT/CT imaging of chemotherapy-induced tumor apoptosis. Generation five poly(amidoamine) (PAMAM) dendrimers (G5.NH2 ) were sequentially conjugated with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), polyethylene glycol (PEG) modified duramycin, PEG monomethyl ether, and fluorescein isothiocyanate (FI) to form the multifunctional dendrimers, which were then utilized as templates to entrap gold nanoparticles...
November 2018: Drug Delivery
Bahareh Babamiri, Rahman Hallaj, Abdollah Salimi
In the present study, we constructed an ultrasensitive solid surface fluorescence-immunosensor based on highly luminescent CdTe@CdS-PAMAM structures as the nanoprobe for determination of HBsAg by monitoring fluorescence intensity. This strategy was achieved by using PAMAM as a signal amplifier, the PAMAM dendrimer with the many functional amine groups can amplify the fluorescence signal of QDs by covalent attachment of CdTe@CdS on PAMAM and hence, improve the sensitivity of the proposed method significantly...
May 31, 2018: Methods and Applications in Fluorescence
Han Wang, Yi Liu, Zhaohui Wang, Man Yang, Yueqing Gu
NO (nitric oxide) has dual functions in cancer, promoting carcinogenesis in low concentrations and inducing tumor cell apoptosis at high concentrations. The dual-edged-sword functions of NO make it particularly appealing to develop a sensitive and specific chemical probe for its detection. However, most NO sensors suffer from poor Stokes shifts and are limited by ultraviolet (UV) or visible light excitation, which render it difficult to avoid the intrinsic background signal. In this study, an 808 nm laser-excited Nd3+-sensitized upconversion nanoprobe based on LRET (luminescence resonance energy-transfer) for NO detection was constructed for the first time...
May 30, 2018: Nanoscale
Ruizhen Jia, Pengfei Song, Jingjing Wang, Hengtang Mai, Sixian Li, Yu Cheng, Song Wu
Carbon monoxide (CO) is recognized as a biologically essential gaseous neurotransmitter that modulates many physiological processes in living subjects. Currently reported fluorescent probes for CO imaging in cells basically utilize palladium related chemistry which requires complicated synthetic work. Herein we provide a new strategy to construct a fluorescent nanoprobe, NanoCO-1, based on the Forster resonance energy transfer (FRET) mechanism by entrapping the existing dirhodium complex as the energy acceptor and the CO recognition part, and a commonly used nitrobenzoxadiazole (NBD) dye as energy donor into a micelle formed by self-assembly...
May 29, 2018: Analytical Chemistry
Myungjae Yang, Duckhyung Cho, Jeongsu Kim, Narae Shin, Shashank Shekhar, Seunghun Hong
A method is developed to directly map nanoscale "noise-source switching" phenomena during the optoelectronic switching of phase-separated polymer nanocomposites of tetrathiafulvalene (TTF) and phenyl-C61 -butyric acid methyl ester (PCBM) molecules dispersed in a polystyrene (PS) matrix. In the method, electrical current and noise maps of the nanocomposite film are recorded using a conducting nanoprobe, enabling the mapping of a conductivity and a noise-source density. The results provide evidence for a repeated modulation in noise sources, a "noise-source switching," in each stage of a switching cycle...
May 27, 2018: Small
Xuelin Li, Dong Wang, Haitao Ran, Lan Hao, Yang Cao, Meng Ao, Nan Zhang, Jiao Song, Liang Zhang, Hengjing Yi, Zhigang Wang, Pan Li
Nanoprobes are small enough to circulate within the vasculature and can reach tumour tissues through the endothelial gap, providing a new strategy for accurate tumour monitoring and imaging-guided antitumour therapy at the molecular level. Both photoacoustic and ultrasonic imaging are noninvasive tools for cancer detection via the application of nanoprobes. In this study, a polymeric multifunctional nanoparticle probe loaded with gold nanorods (Au-NRs) and liquid perfluorocarbon (perfluorinated hexane/PFH) and conjugated to a monoclonal antibody (MAGE-1 antibody) to melanoma-associated antigens (MAGE) targeting melanoma was successfully prepared by the double emulsion and carbodiimide methods as a targeted photoacoustic/ultrasound dual-mode imaging contrast agent (MAGE-Au-PFH-NPs)...
May 24, 2018: Biochemical and Biophysical Research Communications
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