keyword
MENU ▼
Read by QxMD icon Read
search

nanoprobe

keyword
https://www.readbyqxmd.com/read/28343105/photoluminescence-light-up-detection-of-zinc-ion-and-imaging-in-living-cells-based-on-the-aggregation-induced-emission-enhancement-of-glutathione-capped-copper-nanoclusters
#1
Liyun Lin, Yuefang Hu, Liangliang Zhang, Yong Huang, Shulin Zhao
In this work, we prepared glutathione (GSH)-capped copper nanoclusters (Cu NCs) with red emission by simply adjusting the pH of GSH/Cu(2+) mixture at room temperature. A photoluminescence light-up method for detecting Zn(2+) was then developed based on the aggregation induced emission enhancement of GSH-capped Cu NCs. Zn(2+) could trigger the aggregation of Cu NCs, inducing the enhancement of luminescence and the increase of absolute quantum yield from 1.3% to 6.2%. GSH-capped Cu NCs and the formed aggregates were characterized, and the possible mechanism was also discussed...
March 19, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28339208/doubly-resonant-photonic-antenna-for-single-infrared-quantum-dot-imaging-at-telecommunication-wavelengths
#2
Zhihua Xie, Yannick Lefier, Miguel Angel Suarez, Mathieu Mivelle, Roland Salut, Jean-Marc Merolla, Thierry Grosjean
Colloidal quantum dots (CQDs) have drawn strong interest in the past for their high prospects in scientific, medical, and industrial applications. However, the full characterization of these quantum emitters is currently restricted to the visible wavelengths, and it remains a key challenge to optically probe single CQDs operating in the infrared spectral domain, which is targeted by a growing number of applications. Here, we report the first experimental detection and imaging at room temperature of single infrared CQDs operating at telecommunication wavelengths...
March 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28336868/eu-gd-codoped-yttria-nanoprobes-for-optical-and-t%C3%A2-weighted-magnetic-resonance-imaging
#3
Timur Sh Atabaev, Jong Ho Lee, Yong Cheol Shin, Dong-Wook Han, Ki Seok Choo, Ung Bae Jeon, Jae Yeon Hwang, Jeong A Yeom, Hyung-Kook Kim, Yoon-Hwae Hwang
Nanoprobes with multimodal functionality have attracted significant interest recently because of their potential applications in nanomedicine. This paper reports the successful development of lanthanide-doped Y₂O₃ nanoprobes for potential applications in optical and magnetic resonance (MR) imaging. The morphology, structural, and optical properties of these nanoprobes were characterized by transmission electron microscope (TEM), field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), energy-dispersive X-ray (EDX), and photoluminescence (PL)...
February 10, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28335344/a-targeted-nanoprobe-based-on-carbon-nanotubes-natural-biopolymer-chitosan-composites
#4
Baoyan Wu, Na Zhao
A novel targeting theranostic nanoprobe based on single-walled carbon nanotubes (SWCNTs)-natural biopolymer chitosan composites was developed for cancer cell targeting imaging and fluorescence imaging-guided photodynamic therapy. First, chitosan was respectively conjugated with a tumor-homing molecule folic acid, or a photosensitizing drug pyropheophorbide a using a water-soluble carbodiimide coupling chemistry. Chitosan was fluorescently labeled by fluorescein isothiocyanate via the covalently linkage of the isothiocyanate group with the amino group...
November 17, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334690/intracellular-fluorescent-light-up-bioprobes-with-different-morphology-for-image-guided-photothermal-cancer-therapy
#5
Bangbang Li, Peng Zhang, Jianwei Du, Xiao Zhao, Youxiang Wang
Multifunctional nanoprobe was drawing increased attention in tumor diagnosis and therapy. The simple and effective establishment of the theranostic nanoplatforms was still under urgent need. Meanwhile, the targeting ability and morphology of nanoprobe were essential for the effective endocytosis, which could further affect the diagnosis. In this work, two morphologies of nanoprobes were fabricated using gold nanorods (AuNRs) and gold nanospheres (AuNSs). Thiolated-hyaluronic acid labeled with nile blue (HS-HA-NB), a near-infrared (NIR) fluorescence dye, was coated on the surface of the gold nanoparticles to form stable nanoprobes (AuNR@HS-HA-NB, AuNS@HS-HA-NB)...
March 9, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28328200/fluorescence-resonance-energy-transfer-based-dna-tetrahedron-nano-tweezer-for-highly-reliable-detection-of-tumor-related-mrna-in-living-cells
#6
Lei He, Dan-Qing Lu, Hao Liang, Sitao Xie, Can Luo, Miaomiao Hu, Liujun Xu, Xiaobing Zhang, Weihong Tan
Accurate detection and imaging of tumor-related mRNA in living cells hold great promise for early cancer detection. However, currently, most probes designed to image intracellular mRNA confront intrinsic interferences arising from complex biological matrices and resulting in inevitable false-positive signals. To circumvent this problem, a new class of intracellular DNA nanoprobe, termed DNA tetrahedron nano-tweezer (DTNT), was developed to reliably image tumor-related mRNA in living cells based on the FRET (fluorescence resonance energy transfer) "off" to "on" signal readout mode...
March 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28324863/croconaine-nanoparticles-with-enhanced-tumor-accumulation-for-multimodality-cancer-theranostics
#7
Longguang Tang, Fuwu Zhang, Fei Yu, Wenjing Sun, Menglin Song, Xiaoyuan Chen, Xianzhong Zhang, Xiaolian Sun
A novel nanoparticle self-assembled by polyethylene glycol (PEG) modified croconaine dye (CR780) is presented for photoacoustic (PA)/near-infrared (NIR) fluorescence imaging-guided photothermal therapy (PTT). The simple PEGylation made CR780 amphiphilic, and led to their self-assembly into well-defined and uniform nanostructures with size tunable by controlling the assembly conditions. The CR780-PEG5K not only displayed the strength of small molecules (including rapid distribution to different organs, fast renal clearance and minimal accumulation to normal tissues), but also demonstrated the advantages of nanomaterials (including high physiological stability, multimodal theranostic ability, high tumor accumulation and retention)...
March 13, 2017: Biomaterials
https://www.readbyqxmd.com/read/28323416/one-pot-two-nanoprobe-assay-uncovers-targeted-glycoprotein-biosignature
#8
Mira Anne C Dela Rosa, Wei-Chun Chen, Yi-Ju Chen, Rofeamor P Obena, Chih-Hsiang Chang, Rey Y Capangpangan, Tung-Hung Su, Chi-Ling Chen, Pei-Jer Chen, Yu-Ju Chen
We report a one-pot two-nanoprobe approach coupled to mass spectrometry for simultaneous quantification and post-translational modification (PTM) profiling of targeted protein in biofluid. Using N-glycoprotein as model, the assay employs two nanoprobes, antibody-conjugated SiO2 nanoparticles and lectin-conjugated magnetic Fe3O4 nanoparticles, to achieve target glycoprotein isolation from biofluid and subsequent glycopeptide enrichment in a single tube. As demonstrated on α-fetoprotein (AFP), a serum biomarker for hepatocellular carcinoma (HCC), the assay has high purification specificity (20 glycopeptides) with 2-fold and 10-fold superior total glycopeptide intensity compared to non-one-pot method (9 glycopeptides) or without enrichment (6 glycopeptides), respectively...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28323295/augd-integrated-nanoprobes-for-optical-mri-ct-triple-modal-in-vivo-tumor-imaging
#9
Chao Xu, Yaling Wang, Chunyu Zhang, Yanwei Jia, Yunjing Luo, Xueyun Gao
Multi-modal imaging agents are desirable for tumor diagnosis because they can provide more information on the tumor than single-modal imaging agents. However, most reported multi-modal imaging agents are dual-modal agents rather than tri-modal agents; therefore, detailed information on the tumor may still be insufficient when such imaging agents are used. To ameliorate this issue, we synthesized a tri-modal imaging agent, composed of gold cluster and gadolinium oxide integrated nanoparticles (denoted as AuGds) using bovine serum albumin (BSA) as the template via a bio-mineralization method...
March 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28322387/color-resolution-improvement-of-the-dark-field-microscopy-imaging-of-single-light-scattering-plasmonic-nanoprobes-for-microrna-visual-detection
#10
Jun Zhou, Peng Fei Gao, Hong Zhi Zhang, Gang Lei, Lin Ling Zheng, Hui Liu, Cheng Zhi Huang
Imaging of light scattering plasmonic nanoparticles (PNPs) with the aid of the dark-field microscopy imaging (iDFM) technique has attracted wide attention owing to its high signal-to-noise ratio, but to improve the color resolution and contrast of dark-field microscopy (DFM) images of single light scattering PNPs in a small spectral variation environment is still a challenge. In this study, a new color analytical method for resolving the resolution and contrast in DFM images has been developed and further applied for colorimetric analysis using the digital image processing technique...
March 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28322153/recent-progress-in-808-nm-excited-upconversion-nanomaterials-as-multifunctional-nanoprobes-for-visualized-theranostics-in-cancers
#11
Leyong Zeng, Di Wu, Ying Tian, Yuanwei Pan, Aiguo Wu, Jinchao Zhang, Guangming Lu
Near-infrared (NIR) light responsive nanomaterials have attracted considerable attention due to their location in the biological window. Especially, lanthanide-doped nanomaterials exhibit unique upconversion luminescence (UCL) properties with low background interference and long luminescence lifetime, which makes them promising in imaging diagnosis of cancers. Compared with traditional upconversion nanomaterials excited by 980 nm laser, 808 nm excitation can overcome the disadvantages of high heating effect and weak penetration depth induced by excitation source...
March 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28319815/shape-dependent-enzyme-like-activity-of-co3o4-nanoparticles-and-their-conjugation-with-his-tagged-egfr-single-domain-antibody
#12
Wei Zhang, Jinlai Dong, Yang Wu, Peng Cao, Lina Song, Ming Ma, Ning Gu, Yu Zhang
In this study, Co3O4 nanopolyhedrons, nanocubes, nanoplates and nanorods were synthesized and characterized. Furthermore, the peroxidase- and catalase-like activities of these Co3O4 nanoparticles (NPs) were studied and influence of the exposed crystal planes was explored. According to their morphology and peroxidase-like activity, dimercaptosuccinic acid (DMSA) modified Co3O4 nanopolyhedrons synthesized via coprecipitation method (Co3O4 NHs) were selected as a proper candidate for the immunohistochemical (IHC) detection of epidermal growth factor receptor (EGFR) expression in non-small cell lung cancer (NSCLC) tissues...
February 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28303168/nayf4-er-3-yb-3-sio2-core-shell-upconverting-nanocrystals-for-luminescence-thermometry-up-to-900-k
#13
Robin G Geitenbeek, P Tim Prins, Wiebke Albrecht, Alfons van Blaaderen, Bert M Weckhuysen, Andries Meijerink
The rapid development of nanomaterials with unique size-tunable properties forms the basis for a variety of new applications, including temperature sensing. Luminescent nanoparticles (NPs) have demonstrated potential as sensitive nanothermometers, especially in biological systems. Their small size offers the possibility of mapping temperature profiles with high spatial resolution. The temperature range is however limited, which prevents use in high-temperature applications such as, for example, nanoelectronics, thermal barrier coatings, and chemical reactors...
February 16, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
https://www.readbyqxmd.com/read/28301688/multiplex-single-cell-quantification-of-rare-rna-transcripts-from-protoplasts-in-a-model-plant-system
#14
Ulhas S Kadam, Burkhard Schulz, Joseph M K Irudayaraj
Here we demonstrate multiplex and simultaneous detection of four different rare RNA species from plant, Arabidopsis thaliana, using surface enhanced Raman spectroscopy and gold nanoprobes at single cell resolution. We show the applicability of nanoparticle-based Raman spectroscopic sensor to study intracellular RNA copies. First, we demonstrate that gold-nanoparticles decorate with Raman probes and carrying specific nucleic acid probe sequences can be uptaken by the protoplasts. We confirm the internalization of gold nanoprobes by TEM, ICP-MS, and fluorescence imaging...
March 16, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28298082/reliable-f%C3%A3-rster-resonance-energy-transfer-probe-based-on-structure-switching-dna-for-ratiometric-sensing-of-telomerase-in-living-cells
#15
Xue-Jiao Yang, Kai Zhang, Ting-Ting Zhang, Jing-Juan Xu, Hong-Yuan Chen
In situ detection and monitoring of telomerase is of great importance as it is a relatively specific cancer target. However, the complexity of the biological system makes it difficult for the nanoprobe to keep absolutely stable and have a low background in living cells. This study designs a probe termed Förster resonance energy transfer (FRET) nanoflare to achieve ratiometric fluorescent detection of intracellular telomerase with higher specificity, which can effectively resist the disturbance from DNase I and GSH, etc...
March 24, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28296388/degradable-semiconducting-oligomer-amphiphile-for-ratiometric-photoacoustic-imaging-of-hypochlorite
#16
Chao Yin, Xu Zhen, Quli Fan, Wei Huang, Kanyi Pu
Upregulation of highly reactive oxygen species (ROS) such as hypochlorite (ClO-) is associated with many pathological conditions including cardiovascular diseases, neuron degeneration, lung injury and cancer. However, real-time imaging of ClO- is limited to the probes generally relying on fluorescence with shallow tissue-penetration depth. We here propose a self-assembly approach to develop activatable and degradable photoacoustic (PA) nanoprobes for in vivo imaging of ClO-. A near-infrared (NIR) absorbing amphiphilic oligomer was synthesized to undergo degradation in the presence of a specific ROS (ClO-), which integrates a π-conjugated but ClO- oxidizable backbone with hydrophilic PEG side chains...
March 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28295935/real-time-in%C3%A2-vivo-hepatotoxicity-monitoring-through-chromophore-conjugated-photon-upconverting-nanoprobes
#17
Juanjuan Peng, Animesh Samanta, Xiao Zeng, Sanyang Han, Lu Wang, Dongdong Su, Daniel Teh Boon Loong, Nam-Young Kang, Sung-Jin Park, Angelo Homayoun All, Wenxuan Jiang, Lin Yuan, Xiaogang Liu, Young-Tae Chang
Drug toxicity is a long-standing concern of modern medicine. A typical anti-pain/fever drug paracetamol often causes hepatotoxicity due to peroxynitrite ONOO(-) . Conventional blood tests fail to offer real-time unambiguous visualization of such hepatotoxicity in vivo. Here we report a luminescent approach to evaluate acute hepatotoxicity in vivo by chromophore-conjugated upconversion nanoparticles. Upon injection, these nanoprobes mainly accumulate in the liver and the luminescence of nanoparticles remains suppressed owing to energy transfer to the chromophore...
March 15, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28295739/gold-and-hairpin-dna-functionalization-of-upconversion-nanocrystals-for-imaging-and-in-vivo-drug-delivery
#18
Sanyang Han, Animesh Samanta, Xiaoji Xie, Ling Huang, Juanjuan Peng, Sung Jin Park, Daniel Boon Loong Teh, Yongdoo Choi, Young-Tae Chang, Angelo Homayoun All, Yanmei Yang, Bengang Xing, Xiaogang Liu
Although multifunctional upconversion imaging probes have recently attracted considerable interest in biomedical research, there are currently few methods for stabilizing these luminescent nanoprobes with oligonucleotides in biological systems. Herein, a method to robustly disperse upconversion nanoprobes in physiological buffers based on rational design and synthesis of nanoconjugates comprising hairpin-DNA-modified gold nanoparticles is presented. This approach imparts the upconversion nanoprobes with excellent biocompatibility and circumvents the problem of particle agglomeration...
March 10, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28295679/guiding-brain-tumor-surgery-via-blood-brain-barrier-permeable-gold-nanoprobes-with-acid-triggered-mri-serrs-signals
#19
Xihui Gao, Qi Yue, Zining Liu, Mengjing Ke, Xingyu Zhou, Sihan Li, Jianping Zhang, Ren Zhang, Liang Chen, Ying Mao, Cong Li
Surgical resection is a mainstay in the treatment of malignant brain tumors. Surgeons, however, face great challenges in distinguishing tumor margins due to their infiltrated nature. Here, a pair of gold nanoprobes that enter a brain tumor by crossing the blood-brain barrier is developed. The acidic tumor environment triggers their assembly with the concomitant activation of both magnetic resonance (MR) and surface-enhanced resonance Raman spectroscopy (SERRS) signals. While the bulky aggregates continuously trap into the tumor interstitium, the intact nanoprobes in normal brain tissue can be transported back into the blood stream in a timely manner...
March 15, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28292734/fluorescent-nanoprobe-for-in-vivo-ratiometric-imaging-of-endogenous-hydrogen-peroxide-resulted-from-drug-induced-organ-damages
#20
Jin Peng, Xianfeng Hou, Fang Zeng, Shuizhu Wu
Drug-induced organ damages have been considered as a grave problem regarding public health; hence effective method for in vivo detection of drug-induced organ damages is of great significance. Herein we developed a ratiometric fluorescent nanoprobe (NPs-A), which was prepared by loading the probe molecules into phospholipid bilayer, for assaying hydrogen peroxide (H2O2, an organ damage biomarker) level in vivo. The photophysical behavior of the probe molecule depends on the electron-withdrawing ability of the group at the 6- position of anthracene ring, on which the recognition moiety for hydrogen peroxide (dicarbonyl coupled with nitrophenyl, referred to as nitrophenyl-dicarbonyl) was introduced...
March 6, 2017: Biosensors & Bioelectronics
keyword
keyword
51811
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"