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https://www.readbyqxmd.com/read/29148698/chelator-free-conjugation-of-99mtc-and-gd3-to-pegylated-nanographene-oxide-for-dual-modality-spect-mr-imaging-of-lymph-nodes
#1
Tianye Cao, Xiaobao Zhou, Yingying Zheng, Yuyun Sun, Jian Zhang, Wei Chen, Jianping Zhang, Zhiguo Zhou, Shi-Ping Yang, Yingjian Zhang, Hong Yang, Ming-Wei Wang
PEGylated ultra-small nanographene oxide (usNGO-PEG) has exhibited great potential in nanotheranostics due to its newly-discovered physicochemical properties derived from the rich functional groups and  bonds. Herein, we developed a general, simple and kit-like preparation approach for 99mTcI- and Gd-anchored NGO-PEG using a chelator-free strategy. In this strategy, [99mTcI(CO)3(OH2)3]+ (abbreviated to 99mTcI) and GdCl3 were mixed with usNGO-PEG to yield 99mTc- and Gd-usNGO-PEG via the synergistic coordination of N and O atoms from NGO and PEG with 99mTcI and Gd3+ without additional exogenous chelators...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148579/a-step-by-step-review-on-patient-specific-biomechanical-finite-element-models-for-breast-mri-to-x-ray-mammography-registration
#2
REVIEW
Eloy García, Yago Diez, Oliver Diaz, Xavier Lladó, Robert Martí, Joan Martí, Arnau Oliver
Breast magnetic resonance imaging (MRI) and X-ray mammography are two image modalities widely used for the early detection and diagnosis of breast diseases in women. The combination of these modalities leads to a more accurate diagnosis and treatment of breast diseases. The aim of this paper is to review the registration between breast MRI and X-ray mammographic images using patient-specific finite element-based biomechanical models. Specifically, a biomechanical model is obtained from the patient's MRI volume and is subsequently used to mimic the mammographic acquisition...
November 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/29148428/-sup-135-sup-la-as-an-auger-electron-emitter-for-targeted-internal-radiotherapy
#3
Jesper Fonslet, Boon Quan Lee, Thuy A Tran, Mattia Siragusa, Mikael Jensen, Tibor Kibedi, Andrew E Stuchbery, Gregory W Severin
<b>Introduction:</b> <sup>135</sup>La has favorable nuclear and chemical properties for Auger-based targeted internal radiotherapy. Here we present detailed investigations of the production, emissions, imaging characteristics, and dosimetry related to <sup>135</sup>La therapy. <b>Methods and Results:</b> <sup>135</sup>La was produced by 16.5 MeV proton irradiation of metallic <sup>nat</sup>Ba on a medical cyclotron, and was isolated and purified by trap-and-release on weak cation-exchange resin...
November 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29148040/the-endocranial-shape-of-australopithecus-africanus-surface-analysis-of-the-endocasts-of-sts-5-and-sts-60
#4
Amélie Beaudet, Jean Dumoncel, Frikkie de Beer, Stanley Durrleman, Emmanuel Gilissen, Anna Oettlé, Gérard Subsol, John Francis Thackeray, José Braga
Assessment of global endocranial morphology and regional neuroanatomical changes in early hominins is critical for the reconstruction of evolutionary trajectories of cerebral regions in the human lineage. Early evidence of cortical reorganization in specific local areas (e.g. visual cortex, inferior frontal gyrus) is perceptible in the non-human South African hominin fossil record. However, to date, little information is available regarding potential global changes in the early hominin brain. The introduction of non-invasive imaging techniques opens up new perspectives for the study of hominin brain evolution...
November 16, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29145335/clavicle-fracture-associated-with-atlantoaxial-rotatory-displacement-type-ii-in-an-8-year-old-girl-a-case-report
#5
Jacek Karski, Łukasz Matuszewski, Paweł Jakubowski, Klaudia Karska, Grzegorz Kandzierski
RATIONALE: Fracture of the clavicle is a very common injury in children. However, association between clavicle fracture and atlantoaxial rotatory displacement is rarely observed. PATIENT CONCERNS: We present a case of an 8-year-old girl, who suffered a right clavicle fracture as a result of a sledge accident. Six weeks after figure of 8 casting for a right clavicle fracture, an 8-year-old girl was brought to the Pediatric Orthopedic Department due to torticollis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145297/therapeutic-effect-of-neoadjuvant-chemotherapy-combined-with-curettage-to-treat-distal-femoral-osteosarcoma-a-case-report
#6
Qi Lai, Conglin Ye, Tian Gao, Jun Xiao, An Xie, Xuqiang Liu, Xiaolong Yu, Jun Liu, Min Dai, Hucheng Liu, Bin Zhang
RATIONALE: Osteosarcoma is the most common malignant bone tumor in children and adolescents. Metastasis occurs early, the mortality rate is high, and the tumor results in a tremendous physical, mental, and economic burden on patients. Therefore, the treatment of osteosarcoma has been important for orthopedic surgeons. However, treatment has always been a difficult problem globally. PATIENT CONCERN: We present the case of a 22-year-old girl with increasing local pain in the distal left thigh...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145105/the-steel-pan-sign-of-sigmoid-volvulus-a-case-series
#7
Yardesh Singh, Shariful Islam, Ammiel Arra, Renee Banfield, Vijay Naraynsingh
INTRODUCTION: Signs in radiology are usually based on many common objects or patterns that are easily recognizable in everyday life. The objective behind this association is to aid in the understanding and diagnosis of the disease process. These signs can be seen in different imaging modalities such as plain radiograph and computed tomography. PRESENTATION OF CASE: 4 consecutive cases of sigmoid volvulus presented at our tertiary hospital between January 2016 and June 2017...
November 11, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29144983/albumin-coordinated-assembly-of-clearable-platinum-nanodots-for-photo-induced-cancer-theranostics
#8
Yong'an Tang, Tao Yang, Qiaoli Wang, Xiaoyan Lv, Xue Song, Hengte Ke, Zhengqing Guo, Xiaoqing Huang, Jun Hu, Zifu Li, Peng Yang, Xiangliang Yang, Huabing Chen
Photoactive noble metal nanoparticles are of increasing importance toward personalized cancer therapy in the field of precision nanomedicine. A critical challenge remains in the exploration of clinically potential noble metal nanoparticles for highly efficient cancer theranostics. Here, we introduce albumin-coordinated assembly of clearable Pt nanodots (Pt-NDs) with monodisperse nanostructure as high-performance theranostic agents for imaging-guided photothermal tumor ablation. We precisely manipulate the reduction and growth of tetravalent Pt ions into ultrasmall nanodots through albumin-directed growth kinetics, thereby leading to the synthesis of monodisperse 6...
October 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/29143845/pulse-laser-induced-fragmentation-of-carbon-quantum-dots-a-structural-analysis
#9
Han-Wei Chu, Ju-Yi Mao, Chia-Wen Lien, Pang-Hung Hsu, Yu-Jia Li, Jui-Yang Lai, Tai-Chia Chiu, Chih-Ching Huang
Carbon quantum dots (CQDs) have attracted enormous interest in recent years owing to their low cytotoxicity, excellent biocompatibility and strong fluorescence. They have been successfully employed in sensor, bio-imaging, and drug carrier applications. A complete understanding of their core-surface structure is essential for tuning their physical and chemical properties for various applications. Conventional characterizations of CQDs are conducted with electron microscopy or spectroscopy, such as transmission electron microscopy, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy and Raman spectroscopy...
November 16, 2017: Nanoscale
https://www.readbyqxmd.com/read/29143771/doxorubicin-wrapped-zinc-oxide-nanoclusters-for-the-therapy-of-colorectal-adenocarcinoma
#10
Sungyun Kim, Song Yi Lee, Hyun-Jong Cho
Doxorubicin (DOX)-wrapped zinc oxide nanoclusters (ZnO NCs) were developed for the therapy of colorectal cancer. DOX was coated onto the agglomerates of ZnO nanoparticles using a facile coating process. DOX-ZnO NCs with a hydrodynamic size of 170 nm, narrow size distribution, and positive zeta potential were fabricated. The aggregated shape of developed DOX-ZnO NCs was observed by transmission electron microscopy (TEM) imaging. The result of Fourier-transform infrared (FT-IR) analysis suggested the interaction between DOX and ZnO in DOX-ZnO NCs...
October 28, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29143404/tool-for-osteoarthritis-risk-prediction-toarp-over-8-years-using-baseline-clinical-data-x-ray-and-mri-data-from-the-osteoarthritis-initiative
#11
Gabby B Joseph, Charles E McCulloch, Michael C Nevitt, Jan Neumann, Alexandra S Gersing, Martin Kretzschmar, Benedikt J Schwaiger, John A Lynch, Ursula Heilmeier, Nancy E Lane, Thomas M Link
BACKGROUND: Osteoarthritis (OA), a multifactorial disease causing joint degeneration, often leads to severe disability. The rising rates of disability highlight the need for implementing preventative measures at early stages of the disease, which would especially benefit subjects at high risk for OA development. PURPOSE: To develop a risk prediction tool for moderate-severe OA (TOARP) over 8 years based on subject characteristics, knee radiographs, and MRI data at baseline using data from the Osteoarthritis Initiative (OAI)...
November 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29143066/-thoracolumbar-spinal-fractures-in-the-elderly-classification-and-treatment
#12
K J Schnake, P Bula, U J Spiegl, M Müller, F Hartmann, B W Ullrich, T R Blattert
Thoracolumbar fractures in the elderly are frequently associated with osteoporosis. Osteoporosis can cause fractures or be a significant comorbidity in traumatic fractures. The OF classification is based on conventional X‑ray, computed tomography (CT) scan and magnetic resonance imaging (MRI). It is easy to use and provides a clinically relevant classification of the fractures. Therapeutic decisions are made based on the clinical and radiological situation by using the OF score. The score takes the current clinical situation including patient-specific comorbidities into consideration...
November 15, 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/29142808/analyzing-microtomography-data-with-python-and-the-scikit-image-library
#13
Emmanuelle Gouillart, Juan Nunez-Iglesias, Stéfan van der Walt
The exploration and processing of images is a vital aspect of the scientific workflows of many X-ray imaging modalities. Users require tools that combine interactivity, versatility, and performance. scikit-image is an open-source image processing toolkit for the Python language that supports a large variety of file formats and is compatible with 2D and 3D images. The toolkit exposes a simple programming interface, with thematic modules grouping functions according to their purpose, such as image restoration, segmentation, and measurements...
2017: Advanced Structural and Chemical Imaging
https://www.readbyqxmd.com/read/29142344/investigating-the-role-of-global-histogram-equalization-technique-for-99m-technetium-methylene-diphosphonate-bone-scan-image-enhancement
#14
Anil Kumar Pandey, Param Dev Sharma, Pankaj Dheer, Girish Kumar Parida, Harish Goyal, Chetan Patel, Chandrashekhar Bal, Rakesh Kumar
Purpose of the Study: (99m)Technetium-methylene diphosphonate ((99m)Tc-MDP) bone scan images have limited number of counts per pixel, and hence, they have inferior image quality compared to X-rays. Theoretically, global histogram equalization (GHE) technique can improve the contrast of a given image though practical benefits of doing so have only limited acceptance. In this study, we have investigated the effect of GHE technique for (99m)Tc-MDP-bone scan images. Materials and Methods: A set of 89 low contrast (99m)Tc-MDP whole-body bone scan images were included in this study...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29141662/safety-and-tolerability-of-intradiscal-implantation-of-combined-autologous-adipose-derived-mesenchymal-stem-cells-and-hyaluronic-acid-in-patients-with-chronic-discogenic-low-back-pain-1-year-follow-up-of-a-phase-i-study
#15
Hemant Kumar, Doo-Hoe Ha, Eun-Jong Lee, Jun Hee Park, Jeong Hyun Shim, Tae-Keun Ahn, Kyoung-Tae Kim, Alexander E Ropper, Seil Sohn, Chung-Hun Kim, Devang Kashyap Thakor, Soo-Hong Lee, In-Bo Han
BACKGROUND: Adipose tissue-derived mesenchymal stem cells (AT-MSCs) offer potential as a therapeutic option for chronic discogenic low back pain (LBP) because of their immunomodulatory functions and capacity for cartilage differentiation. The goal of this study was to assess the safety and tolerability of a single intradiscal implantation of combined AT-MSCs and hyaluronic acid (HA) derivative in patients with chronic discogenic LBP. METHODS: We performed a single-arm phase I clinical trial with a 12-month follow-up and enrolled 10 eligible chronic LBP patients...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29141630/ct-based-analysis-of-muscle-volume-and-degeneration-of-gluteus-medius-in-patients-with-unilateral-hip-osteoarthritis
#16
Takako Momose, Yutaka Inaba, Hyonmin Choe, Naomi Kobayashi, Taro Tezuka, Tomoyuki Saito
BACKGROUND: The gluteus medius (GMED) affects hip function as an abductor. We evaluated muscle volume and degeneration of the GMED by using CT-based analysis and assessed factors that affect hip abductor strength in patients with unilateral hip osteoarthritis (OA). METHODS: We examined clinical and imaging findings associated with hip abductor strength in consecutive 50 patients with unilateral hip OA. Hip abductor muscle strength and Harris hip score (HHS) were assessed...
November 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29141515/mri-powered-biomedical-devices
#17
Sierra Hovet, Hongliang Ren, Sheng Xu, Bradford Wood, Junichi Tokuda, Zion Tsz Ho Tse
Magnetic resonance imaging (MRI) is beneficial for imaging-guided procedures because it provides higher resolution images and better soft tissue contrast than computed tomography (CT), ultrasound, and X-ray. MRI can be used to streamline diagnostics and treatment because it does not require patients to be repositioned between scans of different areas of the body. It is even possible to use MRI to visualize, power, and control medical devices inside the human body to access remote locations and perform minimally invasive procedures...
November 16, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29140676/synthesis-of-large-area-tungsten-disulfide-films-on-pre-reduced-tungsten-suboxides-substrates
#18
Soo Ho Choi, Stephen Boandoh, Young Ho Lee, Joo Song Lee, Ji-Hoon Park, Soo Min Kim, Woochul Yang, Ki Kang Kim
We report a facile method for the synthesis of large-area tungsten disulfide (WS2) film by means of chemical vapor deposition (CVD). To promote WS2 film growth, the precursor solution, which includes pre-reduced tungsten suboxides, is prepared by using hydrazine as the strong reduction agent and spin-coated onto the growth substrate. Growth is then carried out in a CVD chamber vaporized with dimethyl disulfide (DMDS) as the sulfur precursor. While only WS2 flakes are grown with un-reduced tungsten precursor under hydrogen atmosphere, WS2 film is readily attained on pre-reduced tungsten suboxide substrates without the need for further reduction by hydrogen, which is noted to induce discontinuity of grown film...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29140420/growth-trajectories-breast-size-and-breast-tissue-composition-in-a-british-pre-birth-cohort-of-young-women
#19
Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Martin O Leach, David J Hawkes, Isabel Dos-Santos-Silva
Mammographic % density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations between magnetic resonance imaging (MRI) breast-tissue composition at age 21 years and prospectively-collected measures of body size and composition from birth to early adulthood, and markers of puberty (all standardized), in a sample of 500 nulliparous women from a pre-birth cohort of children born in Avon, England, in 1991-1992 and followed up to 2011-2014...
November 13, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29140321/single-silicon-ccd-cmos-platform-for-multi-spectral-detection-from-terahertz-to-x-rays
#20
Mostafa Shalaby, Carlo Vicario, Christoph P Hauri
Charge-coupled devices (CCDs) are a well-established imaging technology in the visible and x-ray frequency ranges. However, the small quantum photon energies of terahertz radiation have hindered the use of this mature semiconductor technological platform in this frequency range, leaving terahertz imaging totally dependent on low-resolution bolometer technologies. Recently, it has been shown that silicon CCDs can detect terahertz photons at a high field, but the detection sensitivity is limited. Here we show that silicon, complementary metal-oxide-semiconductor (CMOS) technology offers enhanced detection sensitivity of almost two orders of magnitude, compared to CCDs...
November 15, 2017: Optics Letters
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