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https://www.readbyqxmd.com/read/29238221/selective-serotonin-reuptake-inhibitors-and-the-risk-of-hepatocellular-carcinoma-in-hepatitis-b-virus-infected-patients
#1
Chia-Ming Chang, Ming-Shun Hsieh, Tsung-Chieh Yang, Vivian Chia-Rong Hsieh, Jen-Huai Chiang, Hsien-Hao Huang, Chorng-Kuang How, Sung-Yuan Hu, David Hung-Tsang Yen
Background: This study aimed to investigate the association between the use of selective serotonin reuptake inhibitors (SSRIs) and the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. Methods: We conducted a population-based cohort study by using claims data from the Taiwan National Health Insurance Research Database (NHIRD). The study cohort comprised 1380 newly diagnosed HBV-infected patients with SSRI use who were frequency matched by age, sex, liver cirrhosis, and index year with HBV-infected patients without SSRI use in the comparison cohort...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29230549/a-nationwide-survey-of-incidence-rates-and-risk-factors-of-inguinal-hernia-in-preterm-children
#2
Yu-Wei Fu, Mei-Lien Pan, Yao-Jen Hsu, Tai-Wai Chin
PURPOSE: Clinical observations showed a higher incidence rate of inguinal hernia (IH) in preterm infants. In this study, we calculated the incidence rate of preterm IH from the National Health Insurance Research Database (NHIRD) of Taiwan. METHODS: From NHIRD, 92,308 subjects born in the year of 1997-2005 were randomly selected as the study cohort. The medical claims of these subjects from birth to 6th year of age were analyzed. Preterm births were defined using ICD code 765...
December 11, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/29216286/migraine-and-risk-of-narcolepsy-in-children-a-nationwide-longitudinal-study
#3
Chun-Pai Yang, Meng-Lun Hsieh, Jen-Huai Chiang, Hsing-Yi Chang, Vivian Chia-Rong Hsieh
BACKGROUND: The association between migraine and narcolepsy remains controversial. We aim to investigate whether migraine is associated with an increased risk of developing narcolepsy in children. METHODS: In this longitudinal study, nationwide medical-claims data of pediatric patients (0-17y) with migraine are identified using the National Health Insurance Research Database (NHIRD) between 1997 and 2010 in Taiwan. Two cohorts are selected: migraine cases (n = 8,923) and propensity score-matched non-migraine controls (n = 35,692)...
2017: PloS One
https://www.readbyqxmd.com/read/29207978/potential-therapeutic-effects-of-n-butylidenephthalide-from-radix-angelica-sinensis-danggui-in-human-bladder-cancer-cells
#4
Sheng-Chun Chiu, Tsung-Lang Chiu, Sung-Ying Huang, Shu-Fang Chang, Shee-Ping Chen, Cheng-Yoong Pang, Teng-Fu Hsieh
BACKGROUND: N-butylidenephthalide (BP) isolated from Radix Angelica Sinensis (Danggui) exhibits anti-tumorigenic effect in various cancer cells both in vivo and in vitro. The effect of BP in bladder cancer treatment is still unclear and worth for further investigate. METHODS: Changes of patients with bladder cancer after Angelica Sinensis exposure were evaluated by analysis of Taiwan's National Health Insurance Research Database (NHIRD) database. The anti-proliferative effect of BP on human bladder cancer cells was investigated and their cell cycle profiles after BP treatment were determined by flow cytometry...
December 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29194450/risk-of-infertility-following-pelvic-angiographic-embolization-in-female-patients-with-pelvic-fractures-a-nationwide-population-based-cohort-study-in-taiwan
#5
Sheng-Der Hsu, Shih-Yu Lee, Kuen-Tze Lin, Chun-Shu Lin, Wu-Chien Chien, Cheng-Jueng Chen, Chi-Hsiang Chung, Wei-Kuo Chang
Pelvic angiographic embolization is an effective procedure to provide haemostasis in patients with pelvic fractures. However, management with repeated follow-up radiographs may result in infertility. The study aimed to evaluate the risk of infertility following pelvic fracture treated with pelvic angiographic embolization in female patients. We used data from the National Health Insurance Research Database (NHIRD) provided by the Bureau of National Health Insurance of the Department of Health in Taiwan from the period of 1997-2010...
2017: PloS One
https://www.readbyqxmd.com/read/29187868/cisplatin-nephrotoxicity-might-have-a-sex-difference-an-analysis-based-on-women-s-sex-hormone-changes
#6
Wei-Yu Chen, Ching-Hsing Hsiao, Yi-Chen Chen, Chung-Han Ho, Jhi-Joung Wang, Chung-Hsi Hsing, Hsien-Yi Wang, Wei-Chih Kan, Chia-Chun Wu
Background: A sex difference in cisplatin-induced nephrotoxicity (CIN) has been reported in human and animal studies. We examined in humans whether it is associated with sex-hormone changes. Methods: In this retrospective nationwide cohort study, we used Taiwan's National Health Insurance Research Database (NHIRD) to identify patients with a history of malignancy and cisplatin treatment. Patients diagnosed with kidney disease before cisplatin treatment and those with sex-organ malignancies were excluded. A diagnosis of kidney disease within 90 days after the first administration of cisplatin was the study outcome...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29179881/chang-gung-research-database-a-multi-institutional-database-consisting-of-original-medical-records
#7
Ming-Shao Tsai, Meng-Hung Lin, Chuan-Pin Lee, Yao-Hsu Yang, Wen-Cheng Chen, Geng-He Chang, Yao-Te Tsai, Pau-Chung Chen, Ying-Huang Tsai
BACKGROUND: The Chang Gung Research Database (CGRD) is a de-identified database derived from original medical records of Chang Gung Memorial Hospital (CGMH), which comprises seven medical institutes located from the northeast to southern regions of Taiwan. The volume of medical services performed in CGMH is large, and clinical and scientific studies based on the CGRD are reported to be of high quality. However, the CGRD as a useful database for research has not been analyzed before. The objective of the study was to analyze the CGRD with regard to its characteristics and coverage of Taiwan's population...
October 2017: Biomedical Journal
https://www.readbyqxmd.com/read/29177633/osteoporosis-is-associated-with-increased-risk-for-benign-paroxysmal-positional-vertigo-a-nationwide-population-based-study
#8
Kai-Chieh Chan, Yao-Te Tsai, Yao-Hsu Yang, Pau-Chung Chen, Po-Hung Chang
Recent evidence has indicated that osteoporosis is a risk factor for benign paroxysmal positional vertigo (BPPV). This large population-based study demonstrated that patients with osteoporosis had a 1.82-fold higher risk of developing BPPV than those without osteoporosis through the use of the Taiwan National Health Insurance Research Database. PURPOSE: Benign paroxysmal positional vertigo (BPPV) is one of the most frequent causes of vertigo. Osteoporosis reflects a homeostatic imbalance in the rate of bone turnover, with the rate of bone resorption exceeding that of bone formation...
November 25, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29167998/association-of-stroke-subtypes-with-risk-of-hip-fracture-a-population-based-study-in-taiwan
#9
Jing-Quan Zheng, Hui-Ju Lai, Cai-Mei Zheng, Yu-Chun Yen, Kuo-Cheng Lu, Chaur-Jong Hu, Hsun-Hua Lee, Yuan-Hung Wang
Stroke is a critical issue of physical disability. This study aimed to investigate the association of stroke subtypes and hip fracture by using the Taiwan National Health Insurance Research Database. Significantly higher risks of hip fracture were found for female gender and intracerebral hemorrhagic stroke patients. INTRODUCTION: Previous studies reported the increased hip fracture (HF) after acute stroke. Increased falling tendency immobilization-related sarcopenia and underlying comorbidities are related to HF in stroke patients...
November 22, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29163845/improved-medical-expenditure-and-survival-with-integration-of-traditional-chinese-medicine-treatment-in-patients-with-heart-failure-a-nationwide-population-based-cohort-study
#10
Ming-Yen Tsai, Wen-Long Hu, Jen-Huai Chiang, Yu-Chuen Huang, Shih-Yu Chen, Yu-Chiang Hung, Yung-Hsiang Chen
Background: No previous studies have evaluated the effects of traditional Chinese medicine (TCM) treatment on patients with heart failure (HF). Hence, in this study, we determined whether TCM treatment affects the healthcare burden and survival of HF patients. Methods: Samples were retrieved from the registry of catastrophic illness patients of the Taiwan National Health Insurance Research Database (NHIRD). Based on a frequency (1:1) matched case-control design, patients with HF between 2000 and 2010 were designated as cases (TCM users) and controls (non-TCM users)...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29157231/risk-factors-for-contralateral-inguinal-hernia-repair-after-unilateral-inguinal-hernia-repair-in-male-adult-patients-analysis-from-a-nationwide-population-based-cohort-study
#11
Cheng-Hung Lee, Yu-Ting Chiu, Chi-Fu Cheng, Jin-Chia Wu, Wen-Yao Yin, Jian-Han Chen
BACKGROUND: To identify the rate of and risk factors for contralateral inguinal hernia (CIH) after unilateral inguinal hernia repair in adult male patients. METHODS: This retrospective cohort study identified from the Taiwan National Health Insurance Research Database (NHIRD). Information on all adult patients who underwent primary unilateral inguinal hernia repair without any other operation was collected using ICD-9 diagnostic and procedure codes. The exclusion criteria were laparoscopic hernia repair, non-primary repair, complicated hernia, other combined procedures, female and undetermined gender...
November 21, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29142034/cumulative-burden-of-glucocorticoid-related-adverse-events-in-patients-with-systemic-lupus-erythematosus-findings-from-a-12-year-longitudinal-study
#12
Hung-Lin Chen, Li-Jiuan Shen, Ping-Ning Hsu, Chieh-Yu Shen, Susan A Hall, Fei-Yuan Hsiao
OBJECTIVE: The aim of this population-based study is to examine the adverse events (AE) associated with longitudinal systemic glucocorticoid (GC) use among an ethnic Chinese systemic lupus erythematosus (SLE) cohort. METHODS: Our study subjects were patients with newly diagnosed SLE aged 18 and older who received at least 1 prescription of systemic GC between 2001 and 2012 from Taiwan's National Health Insurance Research Database (NHIRD). The earliest prescription date of systemic GC for each subject was defined as the index date...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29136662/protective-effect-of-metformin-against-retinal-vein-occlusions-in-diabetes-mellitus-a-nationwide-population-based-study
#13
Tai-Chi Lin, De-Kuang Hwang, Chih-Chien Hsu, Chi-Hsien Peng, Mong-Lien Wang, Shih-Hwa Chiou, Shih-Jen Chen
Previous studies have found that metformin can reduce cardiovascular risk, but its association with retinal vein occlusion (RVO) is unknown. In this population-based cohort study using the Taiwan National Health Insurance Research Database (NHIRD), we demonstrated the protective effect of metformin against RVO in diabetes mellitus (DM) and explored the incidence rate and factors associated with RVO development in general and diabetic populations. One million patients were randomly selected from the registry files of the NHIRD, and all their claims data were collected for the 1996-2011 period...
2017: PloS One
https://www.readbyqxmd.com/read/29079568/comparative-risk-of-cardiovascular-outcomes-between-topical-and-oral-nonselective-nsaids-in-taiwanese-patients-with-rheumatoid-arthritis
#14
Tzu-Chieh Lin, Daniel H Solomon, Sara K Tedeschi, Kazuki Yoshida, Yea-Huei Kao Yang
BACKGROUND: Topical NSAIDs have less systemic absorption than oral NSAIDs. We examined the risk of cardiovascular events associated with nonselective topical NSAIDs versus oral NSAIDs among patients with rheumatoid arthritis in Taiwan. METHODS AND RESULTS: We conducted a retrospective cohort study that included patients with incident rheumatoid arthritis who were newly starting therapy with nonselective topical NSAIDs or oral NSAIDs. We used the Taiwan National Health Insurance Research Database (NHIRD)...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29060423/an-artificial-neural-network-model-for-the-evaluation-of-carotid-artery-stenting-prognosis-using-a-national-wide-database
#15
Chun-An Cheng, Hung-Wen Chiu
Stroke is a serious health problem in many countries. About 20% of ischemia stroke involves carotid stenosis. Neck carotid ultrasound is fast, secure and convenient way to detect carotid artery stenosis. Carotid artery stenting (CAS) has become a popular treatment for cerebrovascular stenosis in recent years. However, CAS may also induce the occurrence of major adverse cardiovascular events (MACE) in older patients. Hence the evaluation the CAS prognosis is important. In this study, we attempted to construct a model for the evaluation of CAS prognosis by artificial neural network (ANN)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29049192/effect-of-alcohol-intoxication-on-the-risk-of-venous-thromboembolism-a-nationwide-retrospective-cohort-study
#16
Chih-Jung Shen, Chia-Hung Kao, Tai-Yi Hsu, Chih-Yu Chen, Cheng-Li Lin, Hong-Mo Shih
This study investigated whether alcohol intoxication (AI) increases the risk of venous thromboembolism (VTE) by using the Taiwan National Health Insurance Research Database (NHIRD).Using data from the NHIRD, we assembled 61,229 patients with acute AI and randomly selected 244,916 controls. Each patient was monitored from 2000 to 2011 to identify those who were subsequently diagnosed with deep vein thrombosis (DVT) and pulmonary embolism (PE). Cox proportional hazard regression analysis was conducted to determine the risk of VTE in the patients with AI compared with the controls...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29036872/factors-influencing-the-occupational-injuries-of-physical-therapists-in-taiwan-a-hierarchical-linear-model-approach
#17
Yu-Hui Tao, Yu-Lung Wu, Wan-Yun Huang
BACKGROUND: The evidence literature suggests that physical therapy practitioners are subjected to a high probability of acquiring work-related injuries, but only a few studies have specifically investigated Taiwanese physical therapy practitioners. OBJECTIVE: This study was conducted to determine the relationships among individual and group hospital-level factors that contribute to the medical expenses for the occupational injuries of physical therapy practitioners in Taiwan...
October 8, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28992891/patterns-of-medical-utilization-before-the-first-hospitalization-for-women-with-anorexia-nervosa-in-taiwan
#18
Yen-Ni Hung, Chian-Jue Kuo, Shu-Yu Yang, Ming-Chyi Huang, Ying-Yeh Chen, Shih-Ku Lin, Kuan-Yu Chen
OBJECTIVE: The aim of this paper was to analyze medical utilization patterns of female patients with anorexia nervosa before their first inpatient care visit for anorexia nervosa using the National Health Insurance Research Database (NHIRD) of Taiwan. METHOD: We selected female anorexia nervosa patients (n=239) and control participants hospitalized for peptic ulcers (n=478) or appendectomy (n=478) who were matched by age and incident year from two subsets of the NHIRD...
November 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28991722/risk-of-psychiatric-disorders-in-guillain-barre-syndrome-a-nationwide-population-based-cohort-study
#19
Nian-Sheng Tzeng, Hsin-An Chang, Chi-Hsiang Chung, Fu-Huang Lin, Chin-Bin Yeh, San-Yuan Huang, Chuan-Chia Chang, Ru-Band Lu, Yu-Chen Kao, Hui-Wen Yeh, Wei-Shan Chiang, Wu-Chien Chien
BACKGROUND: Guillain-Barre syndrome (GBS) is a rare immune-related neurological disorder with high mortality and morbidity, but the comorbid psychiatric disorders garnered little attention in the GBS patients. This study aimed to investigate the association between GBS and the risk of developing psychiatric disorders. METHODS: A total of 18,192 enrolled patients, with 4548 study subjects who had suffered GBS, and 13,644 controls matched for gender and age, from the Inpatient Dataset of 2000-2013 in Taiwan, and selected from the National Health Insurance Research Database (NHIRD)...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28977886/combined-renin-angiotensin-aldosterone-system-blockade-and-statin-therapy-effectively-reduces-the-risk-of-cerebrovascular-accident-in-autosomal-dominant-polycystic-kidney-disease-a-nationwide-population-based-cohort-study
#20
Pei-Hsun Sung, Hsin-Ju Chiang, Mel S Lee, John Y Chiang, Hon-Kan Yip, Yao-Hsu Yang
Fairly limited data reported the incidence and risk of cerebrovascular accident (CVA) in autosomal dominant polycystic kidney disease (ADPKD). Additionally, little is known regarding the therapeutic impact of renin-angiotensin-aldosterone system (RAAS) blockade and statin on reducing the occurrence of CVA in ADPKD. We utilized the data from Taiwan National Health Insurance Research Database (NHIRD) to perform a population-based cohort study (1997-2013). A total of 2,647 patients with ADPKD were selected from 1,000,000 general population after excluding patients with age<18, renal replacement therapy and concomitant diagnosis of CVA...
September 22, 2017: Oncotarget
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