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https://www.readbyqxmd.com/read/29648667/epidemiology-risk-factors-and-characteristics-of-pediatric-stroke-a-nationwide-population-based-study
#1
Kuo-Liang Chiang, Chen-Yang Cheng
Background: Stroke, classically characterized as an acute acquired neurological deficit, is an important leading cause of death and chronic morbidity in children. Aims: This study reported the period prevalence, incidence, and risk factors of pediatric stroke in Taiwan. Methods and Procedures: All Taiwan inhabitants aged 1 month to 18 years registered in the National Health Insurance Research Database (NHIRD) between 2010 and 2011 were enrolled in this study...
April 10, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29624580/estimating-the-response-and-economic-burden-of-rheumatoid-arthritis-patients-treated-with-biologic-disease-modifying-antirheumatic-drugs-in-taiwan-using-the-national-health-insurance-research-database-nhird
#2
Qiang Shi, Ko-Jen Li, Tamas Treuer, Bruce C M Wang, Carol L Gaich, Chien-Hsun Lee, Wen-Shuo Wu, Wesley Furnback, Chao-Hsiun Tang
BACKGROUND: Previous studies in Taiwan utilizing the Taiwan's National Health Insurance Database (NHIRD) have estimated the direct healthcare costs of RA patients, but they have not focused on patients on bDMARDs, or considered patients' response to therapy. OBJECTIVES: The objective of this study was to estimate the rate of inadequate response for patients newly treated with biologic disease-modifying antirheumatic drugs (bDMARDs) as well as their costs and resource use...
2018: PloS One
https://www.readbyqxmd.com/read/29623039/simvastatin-therapy-for-drug-repositioning-to-reduce-the-risk-of-prostate-cancer-mortality-in-patients-with-hyperlipidemia
#3
Yu-An Chen, Ying-Ju Lin, Cheng-Li Lin, Hwai-Jeng Lin, Hua-Shan Wu, Hui-Ying Hsu, Yu-Chen Sun, Hui-Yu Wu, Chih-Ho Lai, Chia-Hung Kao
Prostate cancer (PCa) is one of the most commonly diagnosed cancers in the western world, and the mortality rate from PCa in Asia has been increasing recently. Statins are potent inhibitors of 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase and are commonly used for treating hyperlipidemia, with beneficial effects for cardiovascular disease and they also exhibit anti-cancer activity. However, the protective effects of statins against PCa are controversial. In this study, we investigated the effect of two types of statins (simvastatin and lovastatin) and the mortality rate of PCa patients by using the Taiwan National Health Insurance Research Database (NHIRD)...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29606115/number-of-cholangitis-episodes-as-a-prognostic-marker-to-predict-timing-of-liver-transplantation-in-biliary-atresia-patients-after-kasai-portoenterostomy
#4
Szu-Ying Chen, Chieh-Chung Lin, Yu-Tse Tsan, Wei-Cheng Chan, Jiaan-Der Wang, Yi-Jung Chou, Ching-Heng Lin
BACKGROUND: Cholangitis may affect liver failure of biliary atresia (BA) patients after Kasai portoenterostomy (KP). We examined whether the number of cholangitis episodes could be a prognostic marker for liver transplant (LT) in children with BA after Kasai portoenterostomy (KP). METHODS: Data for BA patients born after 1998 and undergoing KP were obtained from National Health Insurance Research Database (NHIRD), Taiwan. Patients were followed up until the end of 2011...
April 2, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29587654/antepartum-urinary-tract-infection-and-postpartum-depression-in-taiwan-a-nationwide-population-based-study
#5
Jui-Ming Liu, Feng-Hsiang Chiu, Yueh-Ping Liu, Shu-Pin Chen, Hsun-Hao Chan, Jing-Jung Yang, Fung-Wei Chang, Ren-Jun Hsu
BACKGROUND: Urinary tract infections (UTIs) are among the most common bacterial infections in pregnant women due to anatomic and physiologic changes in the female urinary tract during pregnancy, and antepartum UTIs can cause adverse pregnancy outcomes that may induce mental stress. There have only been a few studies, however, investigating antepartum UTIs and mental stress. As such, the present study was conducted in order to investigate the association between antepartum UTIs and postpartum depression (PPD)...
March 27, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29565957/association-of-higher-migraine-risk-among-female-and-younger-chronic-osteomyelitis-patients-evidence-from-a-taiwan-cohort-of-one-million
#6
Jiunn-Horng Chen, Shih-Chi Wu, Chih-Hsin Muo, Chia-Hung Kao, Chun-Hung Tseng, Chon-Haw Tsai
BACKGROUND: Inflammation may trigger migraine development through neurovascular reactions in the brain. Most of the migraine patients, particularly the younger ones, do not have any risk factors for this disease. Hence, we assessed whether chronic osteomyelitis (COM), a chronic inflammatory disease, increases the risk of migraine. OBJECTIVE: We aim to evaluate the risk of migraine among female and middle-age COM patients with a large patient sample. STUDY DESIGN: A retrospective cohort study was conducted in this study...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29561423/risks-of-female-genital-tract-related-cancers-gynecological-cancers-or-breast-cancer-in-women-with-and-without-chronic-kidney-disease-a-population-based-cohort-study-in-taiwan
#7
Wen-Hsun Chang, Huann-Cheng Horng, Chang-Ching Yeh, Chao-Yu Guo, Yiing-Jeng Chou, Nicole Huang, Hsin-Yi Huang, Yi-Jen Chen, Wen-Ling Lee, Peng-Hui Wang
This article aims to test the hypothesis that the risk of female genital tract related cancer (gynecological cancer: GC) or breast cancer (BC) of women with chronic kidney disease (CKD) might be different from that of those women without CKD.A nationwide 17-year historic cohort study using the National Health Insurance Research Database (NHIRD) of Taiwan and the Registry for Catastrophic Illness Patients was conducted. A total of 3045 women with a diagnosis of CKD from 1996 to 2013 and 3045 multivariable-matched controls (1:1) were selected...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29560612/association-between-nonsteroidal-anti-inflammatory-drugs-and-atrial-fibrillation-among-a-middle-aged-population-a-nationwide-population-based-cohort
#8
Shao-Yuan Chuang, Pai-Feng Hsu, Fang-Ju Lin, Ya-Wen Huang, Gou-Zhau Wang, Wei-Chiao Chang, Hui-Ju Tsai
AIMS: It remains inconclusive whether the use of nonsteroidal anti-inflammatory drugs (NSAIDs) increases the risk of atrial fibrillation (AF), especially in middle-aged Asian populations. In this study, we evaluated the association between NSAID use and the risk of AF in a nationwide population-based study of middle-aged individuals in Taiwan. METHODS: A nested case-control study was conducted using the National Health Insurance Research Database (NHIRD) in Taiwan...
March 20, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29559181/the-effectiveness-and-safety-of-low-dose-rivaroxaban-in-asians-with-non-valvular-atrial-fibrillation
#9
Hsin-Fu Lee, Yi-Hsin Chan, Hui-Tzu Tu, Chi-Tai Kuo, Yung-Hsin Yeh, Shang-Hung Chang, Lung-Sheng Wu, Lai-Chu See
BACKGROUND: Rivaroxaban (20 mg/15 mg once daily) is an effective and safe alternative to warfarin for stroke prevention in patients with non-valvular AF (NVAF). Low-dose rivaroxaban (15 mg/10 mg once daily) has been only approved for NVAF patients in Japan and Taiwan, although its effectiveness and safety at low doses remain unclear among Asians with NVAF. The objective of the study is to compare the effectiveness and safety of low-dose rivaroxaban to those of warfarin among Asians with NVAF...
March 14, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29554872/epidemiology-and-long-term-disease-burden-of-herpes-zoster-and-postherpetic-neuralgia-in-taiwan-a-population-based-propensity-score-matched-cohort-study
#10
Wan-Hsuan Lu, Chih-Wan Lin, Chen-Yu Wang, Liang-Kung Chen, Fei-Yuan Hsiao
BACKGROUND: The objectives of this study were to characterize the burden of herpes zoster, as well as the longitudinal and incremental changes of healthcare service utilization among individuals with herpes zoster and postherpetic neuralgia (PHN) compared to those without. METHODS: Using the National Health Insurance Research Database (NHIRD), we established a herpes zoster cohort of people diagnosed with herpes zoster between 2004 and 2008 as study cases. Another subset of the NHIRD, which was randomly selected from all elderly beneficiaries between 2004 and 2008 served as a non-herpes-zoster elderly control pool...
March 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29541810/nationwide-study-on-the-risk-of-unprovoked-venous-thromboembolism-in-non-traumatic-osteonecrosis-of-femoral-head
#11
Pei-Hsun Sung, Hsin-Ju Chiang, Yao-Hsu Yang, John Y Chiang, Chi-Jen Chen, Hon-Kan Yip, Mel S Lee
PURPOSE: Endothelial dysfunction is a risk factor for osteonecrosis of femoral head (ONFH) and venous thromboembolism (VTE) [defined as deep venous thrombosis (DVT) or pulmonary embolism (PE)]. However, the risk of unprovoked VTE in non-traumatic ONFH patients remains unclear. METHODS: We investigated the relationship between ONFH and VTE using Taiwan National Health Insurance Research Database (NHIRD). Between 1997 and 2010, a total of 1514 non-traumatic ONFH patients were identified from 1,000,000 general populations after excluding initially concomitant diagnoses of DVT and PE, and subjects undergoing lower limb surgery within one year since enrollment...
March 14, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29540710/an-epidemiological-human-disease-network-derived-from-disease-co-occurrence-in-taiwan
#12
Yefei Jiang, Shuangge Ma, Ben-Chang Shia, Tian-Shyug Lee
In "classic" biomedical research, diseases have usually been studied individually. The pioneering human disease network (HDN) studies jointly consider a large number of diseases, analyse their interconnections, and provide a more comprehensive description of diseases. However, most of the existing HDN studies are based on molecular information and can only partially describe disease interconnections. Building on the unique Taiwan National Health Insurance Research Database (NHIRD), in this study, we construct the epidemiological HDN (eHDN), where two diseases are concluded as interconnected if their observed probability of co-occurrence deviating that expected under independence...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29488144/anti-herpetic-medications-and-reduced-risk-of-dementia-in-patients-with-herpes-simplex-virus-infections-a-nationwide-population-based-cohort-study-in-taiwan
#13
Nian-Sheng Tzeng, Chi-Hsiang Chung, Fu-Huang Lin, Chien-Ping Chiang, Chin-Bin Yeh, San-Yuan Huang, Ru-Band Lu, Hsin-An Chang, Yu-Chen Kao, Hui-Wen Yeh, Wei-Shan Chiang, Yu-Ching Chou, Chang-Huei Tsao, Yung-Fu Wu, Wu-Chien Chien
This retrospective cohort study is to investigate the association between herpes simplex virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk involved, using Taiwan's National Health Insurance Research Database (NHIRD). We enrolled a total of 33,448 subjects, and identified 8362 with newly diagnosed HSV infections and 25,086 randomly selected sex- and age-matched controls without HSV infections in a ratio of 1:3, selected from January 1, to December 31, 2000. A multivariable Cox proportional hazards regression model was used to evaluate the risk of developing dementia in the HSV cohort...
February 27, 2018: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/29481993/long-term-use-of-valproic-acid-and-the-prevalence-of-cancers-in-bipolar-disorder-patients-in-a-taiwanese-population-an-association-analysis-using-the-national-health-insurance-research-database-nhird
#14
Cheng Chia Lin, Tsung-Cheng Hsieh, Lawrence Shih-Hsin Wu
BACKGROUND: Epigenetic events play a major role in the carcinogenesis of many cancers. A retrospective cohort study had been performed to evaluate the effects of exposure to the anticonvulsant agent valproic acid (VPA), a histone deacetylase inhibitor, on the risk of developing cancers. METHODS: The study was based on the 1998 through 2009 National Health Insurance Research Database (NHIRD), provided by the Taiwan National Health Research Institute. Patients with a diagnosis of bipolar disorder (ICD-9-CM codes 296...
February 19, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29416815/increased-risk-of-malignancy-in-patients-with-an-aortic-aneurysm-a-nationwide-population-based-retrospective-study
#15
Jen-Chun Wang, Wu-Chien Chien, Chi-Hsiang Chung, Wen-I Liao, Chang-Huei Tsao, Yung-Fu Wu, Shih-Hung Tsai
Background: Cardiovascular disease and malignancy have numerous similarities and possible interactions, as these diseases share several risk factors, epidemiological features and biological signaling pathways. Data regarding the risk of malignancy in patients with aortic aneurysm (AA) are scarce. We aimed to determine whether patients with AA have an increased risk of malignancy. Materials and Methods: The data for the nationwide population-based retrospective cohort study described herein were obtained from the Taiwan National Health Insurance Research Database (NHIRD)...
January 5, 2018: Oncotarget
https://www.readbyqxmd.com/read/29407535/change-in-1-year-hospitalization-of-overall-and-older-patients-with-major-depressive-disorder-after-second-generation-antipsychotics-augmentation-treatment
#16
Chun-Yuan Lin, Te-Jen Lai, Yu-Hsin Wu, Ping-Kun Chen, Yuan-Fu Lin, I-Chia Chien
BACKGROUND: Studies on second-generation antipsychotics (SGA) augmentation treatment for older adults with major depressive disorder (MDD) remain limited. We aimed to investigate the effectiveness of SGA augmentation for overall and older patients with MDD inpatient history by assessing the change in 1-year hospitalization before and after SGA augmentation using the latest National Health Insurance Research Database (NHIRD) in Taiwan. METHODS: The samples were MDD patients (ICD-9 CM code: 296...
January 31, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29397431/risk-of-colorectal-cancer-in-patients-with-periodontal-disease-severity-a-nationwide-population-based-cohort-study
#17
Je-Ming Hu, Cheng-Jung Shen, Yu-Ching Chou, Chi-Feng Hung, Yu-Feng Tian, San-Lin You, Chao-Yang Chen, Chih-Hsiung Hsu, Cheng-Wen Hsiao, Chun-Yu Lin, Chien-An Sun
BACKGROUND: Periodontal disease (PD) and colorectal cancer (CRC) were associated with chronic inflammation. This retrospective cohort study examined the association between PD severity and CRC in a large-scale, population-based Chinese cohort. METHODS: A total of approximately 106,487 individuals with newly diagnosed PD and 106,487 age-matched and sex-matched patients without PD from 2000 to 2002 were identified from Taiwan's National Health Insurance Research Database (NHIRD)...
February 3, 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29396235/investigation-of-treatment-pattern-medical-resource-utilization-and-demographic-prognostic-factors-in-older-patients-with-non-hodgkin-lymphoma-a-nationwide-population-based-study
#18
Shih-Feng Cho, Wan-Hsuan Wu, Yi-Hsin Yang, Yi-Chang Liu, Hui-Hua Hsiao, Chao-Sung Chang
BACKGROUND: This nationwide population study aimed to investigate treatment patterns, medical resource utilization and demographic prognostic factors in older Taiwanese patients with non-Hodgkin lymphoma (NHL). PATIENTS AND METHODS: This study was conducted using the National Health Insurance Research Database (NHIRD) of Taiwan. The older patients (65years or older) diagnosed with NHL between 1997 and 2008 were identified for analysis. RESULTS: A total of 5136 patients (3049 males and 2087 females) with a median age of 74...
January 26, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29375226/increased-risk-of-venous-thromboembolism-in-women-with-uterine-leiomyoma-a-nationwide-population-based-case-control-study
#19
Hung-Kai Huang, Chew-Teng Kor, Ching-Pei Chen, Hung-Te Chen, Po-Ta Yang, Chen-Dao Tsai, Ching-Hui Huang
Background: Venous thromboembolism (VTE) is a sex-specific disease that has different presentations between men and women. Women with uterine leiomyoma can present with VTE without exhibiting the traditional risk factors. We investigated the relationship between a history of uterine leiomyoma and the risk of VTE using the National Health Insurance Research Database (NHIRD). Methods: We conducted a retrospective, nationwide, population-based case-control study using the NHIRD...
January 2018: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/29374659/impact-of-hepatitis-c-virus-infection-on-long-term-mortality-after-acute-myocardial-infarction-a-nationwide-population-based-propensity-matched-cohort-study-in-taiwan
#20
Shu-Hung Kuo, Wang-Ting Hung, Pei-Ling Tang, Wei-Chun Huang, Jin-Shiou Yang, Hsiao-Chin Lin, Guang-Yuan Mar, Hong-Tai Chang, Chun-Peng Liu
INTRODUCTION: The influence of hepatitis C virus (HCV) infection on long-term outcomes of patients with acute myocardial infarction (AMI) is unclear. Therefore, this study aimed to analyse the impact of HCV infection on 12-year mortality rates after AMI using data from the Taiwan National Health Insurance Research Database (NHIRD). METHODS: NHIRD data for approximately 23 000 000 patients between January 2000 and December 2012 were analysed. A total of 186 112 cases of first AMI admission were identified...
January 26, 2018: BMJ Open
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