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Jen-Chun Wang, Wu-Chien Chien, Chi-Hsiang Chung, Wen-I Liao, Chang-Huei Tsao, Yung-Fu Wu, Shih-Hung Tsai
Background: Cardiovascular disease and malignancy have numerous similarities and possible interactions, as these diseases share several risk factors, epidemiological features and biological signaling pathways. Data regarding the risk of malignancy in patients with aortic aneurysm (AA) are scarce. We aimed to determine whether patients with AA have an increased risk of malignancy. Materials and Methods: The data for the nationwide population-based retrospective cohort study described herein were obtained from the Taiwan National Health Insurance Research Database (NHIRD)...
January 5, 2018: Oncotarget
Chun-Yuan Lin, Te-Jen Lai, Yu-Hsin Wu, Ping-Kun Chen, Yuan-Fu Lin, I-Chia Chien
BACKGROUND: Studies on second-generation antipsychotics (SGA) augmentation treatment for older adults with major depressive disorder (MDD) remain limited. We aimed to investigate the effectiveness of SGA augmentation for overall and older patients with MDD inpatient history by assessing the change in 1-year hospitalization before and after SGA augmentation using the latest National Health Insurance Research Database (NHIRD) in Taiwan. METHODS: The samples were MDD patients (ICD-9 CM code: 296...
January 31, 2018: Journal of Affective Disorders
Je-Ming Hu, Cheng-Jung Shen, Yu-Ching Chou, Chi-Feng Hung, Yu-Feng Tian, San-Lin You, Chao-Yang Chen, Chih-Hsiung Hsu, Cheng-Wen Hsiao, Chun-Yu Lin, Chien-An Sun
BACKGROUND: Periodontal disease (PD) and colorectal cancer (CRC) were associated with chronic inflammation. This retrospective cohort study examined the association between PD severity and CRC in a large-scale, population-based Chinese cohort. METHODS: A total of approximately 106,487 individuals with newly diagnosed PD and 106,487 age-matched and sex-matched patients without PD from 2000 to 2002 were identified from Taiwan's National Health Insurance Research Database (NHIRD)...
February 3, 2018: International Journal of Colorectal Disease
Shih-Feng Cho, Wan-Hsuan Wu, Yi-Hsin Yang, Yi-Chang Liu, Hui-Hua Hsiao, Chao-Sung Chang
BACKGROUND: This nationwide population study aimed to investigate treatment patterns, medical resource utilization and demographic prognostic factors in older Taiwanese patients with non-Hodgkin lymphoma (NHL). PATIENTS AND METHODS: This study was conducted using the National Health Insurance Research Database (NHIRD) of Taiwan. The older patients (65years or older) diagnosed with NHL between 1997 and 2008 were identified for analysis. RESULTS: A total of 5136 patients (3049 males and 2087 females) with a median age of 74...
January 26, 2018: Journal of Geriatric Oncology
Hung-Kai Huang, Chew-Teng Kor, Ching-Pei Chen, Hung-Te Chen, Po-Ta Yang, Chen-Dao Tsai, Ching-Hui Huang
Background: Venous thromboembolism (VTE) is a sex-specific disease that has different presentations between men and women. Women with uterine leiomyoma can present with VTE without exhibiting the traditional risk factors. We investigated the relationship between a history of uterine leiomyoma and the risk of VTE using the National Health Insurance Research Database (NHIRD). Methods: We conducted a retrospective, nationwide, population-based case-control study using the NHIRD...
January 2018: Acta Cardiologica Sinica
Shu-Hung Kuo, Wang-Ting Hung, Pei-Ling Tang, Wei-Chun Huang, Jin-Shiou Yang, Hsiao-Chin Lin, Guang-Yuan Mar, Hong-Tai Chang, Chun-Peng Liu
INTRODUCTION: The influence of hepatitis C virus (HCV) infection on long-term outcomes of patients with acute myocardial infarction (AMI) is unclear. Therefore, this study aimed to analyse the impact of HCV infection on 12-year mortality rates after AMI using data from the Taiwan National Health Insurance Research Database (NHIRD). METHODS: NHIRD data for approximately 23 000 000 patients between January 2000 and December 2012 were analysed. A total of 186 112 cases of first AMI admission were identified...
January 26, 2018: BMJ Open
Hong-Wei Tam, Chyong-Mei Chen, Pui-Ying Leong, Chao-Hsi Chen, Yuan-Chao Li, Yu-Hsun Wang, Li-Chi Lin, Jeng-Yuan Chiou, James Cheng-Chung Wei
AIM: To investigate the effects of hydroxychloroquine, sulfasalazine and methotrexate on ischemic stroke in patients with rheumatoid arthritis (RA). METHODS: This population-based retrospective cohort study included 7904 RA patients and 15 808 non-RA patients between 2000 and 2010. All of the participants were sampled from the National Health Insurance Research Database (NHIRD) of Taiwan. Using univariate analyses, these two groups of patients were compared to evaluate the differences in disease-modifying anti-rheumatic drugs usage and demographic variables...
January 25, 2018: International Journal of Rheumatic Diseases
Yueh-Ping Liu, Ren-Jun Hsu, Mei-Hwan Wu, Chun-Chih Peng, Shu-Ting Chang, Wei-Te Lei, Tzu-Lin Yeh, Jui-Ming Liu, Chien-Yu Lin
Childhood injuries are unfortunately common. Analysis procedures may assist professionals who work with children with developing preventive measures for protecting children's wellness. This study explores the causes of pediatric injuries presenting to an emergency department in Taiwan. This nationwide, population-based study was conducted using data from the National Health Insurance Research Database of Taiwan (NHIRD). Patients aged <18 years were identified from approximately one million individuals listed in the NHIRD...
January 23, 2018: International Journal of Environmental Research and Public Health
Yu-Ning Chien, Ping-Ling Chen, Yi-Hua Chen, Hsiu-Ju Chang, Suh-Ching Yang, Yi Chun Chen, Hung-Yi Chiou
The objective of the study was to introduce the methodology and report on cohort description of Taiwan Adolescent to Adult Longitudinal Study (TAALS). TAALS is the first nationwide longitudinal survey among Taiwan adolescents, linked with the National Health Insurance Research Database (NHIRD) to obtain complete medical records of respondents in the future. The TAALS project employed the principle of probability proportional to size (PPS) sampling method. Data were collected by questionnaire from 18 064 school students participating in 2015 formal survey, with good sample representation via a goodness-of-fit test after weighting adjustments...
January 1, 2018: Asia-Pacific Journal of Public Health
Tomor Harnod, Cheng-Li Lin, Chia-Hung Kao
OBJECTIVE: We would like to exam whether epilepsy patients in Taiwan have a high risk of attempted and completed suicide. METHODS: In this study, we used a subset of the National Health Insurance Research Database (NHIRD) of Taiwan. Inpatients (≥ 18 years) who received a new diagnosis of epilepsy between 2000 and 2011 were enrolled in the epilepsy cohort. The epilepsy and comparison cohorts included 68,543 patients and 2-fold controls respectively. We calculated the adjusted hazard ratio (aHR) for suicide attempts after adjustment for age, sex, monthly income, the urbanization level, occupation, and comorbidity...
December 29, 2017: Journal of Affective Disorders
Chia-Ming Chang, Ming-Shun Hsieh, Tsung-Chieh Yang, Vivian Chia-Rong Hsieh, Jen-Huai Chiang, Hsien-Hao Huang, Chorng-Kuang How, Sung-Yuan Hu, David Hung-Tsang Yen
Background: This study aimed to investigate the association between the use of selective serotonin reuptake inhibitors (SSRIs) and the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection. Methods: We conducted a population-based cohort study by using claims data from the Taiwan National Health Insurance Research Database (NHIRD). The study cohort comprised 1380 newly diagnosed HBV-infected patients with SSRI use who were frequency matched by age, sex, liver cirrhosis, and index year with HBV-infected patients without SSRI use in the comparison cohort...
2017: Cancer Management and Research
Yu-Wei Fu, Mei-Lien Pan, Yao-Jen Hsu, Tai-Wai Chin
PURPOSE: Clinical observations showed a higher incidence rate of inguinal hernia (IH) in preterm infants. In this study, we calculated the incidence rate of preterm IH from the National Health Insurance Research Database (NHIRD) of Taiwan. METHODS: From NHIRD, 92,308 subjects born in the year of 1997-2005 were randomly selected as the study cohort. The medical claims of these subjects from birth to 6th year of age were analyzed. Preterm births were defined using ICD code 765...
December 11, 2017: Pediatric Surgery International
Chun-Pai Yang, Meng-Lun Hsieh, Jen-Huai Chiang, Hsing-Yi Chang, Vivian Chia-Rong Hsieh
BACKGROUND: The association between migraine and narcolepsy remains controversial. We aim to investigate whether migraine is associated with an increased risk of developing narcolepsy in children. METHODS: In this longitudinal study, nationwide medical-claims data of pediatric patients (0-17y) with migraine are identified using the National Health Insurance Research Database (NHIRD) between 1997 and 2010 in Taiwan. Two cohorts are selected: migraine cases (n = 8,923) and propensity score-matched non-migraine controls (n = 35,692)...
2017: PloS One
Sheng-Chun Chiu, Tsung-Lang Chiu, Sung-Ying Huang, Shu-Fang Chang, Shee-Ping Chen, Cheng-Yoong Pang, Teng-Fu Hsieh
BACKGROUND: N-butylidenephthalide (BP) isolated from Radix Angelica Sinensis (Danggui) exhibits anti-tumorigenic effect in various cancer cells both in vivo and in vitro. The effect of BP in bladder cancer treatment is still unclear and worth for further investigate. METHODS: Changes of patients with bladder cancer after Angelica Sinensis exposure were evaluated by analysis of Taiwan's National Health Insurance Research Database (NHIRD) database. The anti-proliferative effect of BP on human bladder cancer cells was investigated and their cell cycle profiles after BP treatment were determined by flow cytometry...
December 6, 2017: BMC Complementary and Alternative Medicine
Sheng-Der Hsu, Shih-Yu Lee, Kuen-Tze Lin, Chun-Shu Lin, Wu-Chien Chien, Cheng-Jueng Chen, Chi-Hsiang Chung, Wei-Kuo Chang
Pelvic angiographic embolization is an effective procedure to provide haemostasis in patients with pelvic fractures. However, management with repeated follow-up radiographs may result in infertility. The study aimed to evaluate the risk of infertility following pelvic fracture treated with pelvic angiographic embolization in female patients. We used data from the National Health Insurance Research Database (NHIRD) provided by the Bureau of National Health Insurance of the Department of Health in Taiwan from the period of 1997-2010...
2017: PloS One
Wei-Yu Chen, Ching-Hsing Hsiao, Yi-Chen Chen, Chung-Han Ho, Jhi-Joung Wang, Chung-Hsi Hsing, Hsien-Yi Wang, Wei-Chih Kan, Chia-Chun Wu
Background: A sex difference in cisplatin-induced nephrotoxicity (CIN) has been reported in human and animal studies. We examined in humans whether it is associated with sex-hormone changes. Methods: In this retrospective nationwide cohort study, we used Taiwan's National Health Insurance Research Database (NHIRD) to identify patients with a history of malignancy and cisplatin treatment. Patients diagnosed with kidney disease before cisplatin treatment and those with sex-organ malignancies were excluded. A diagnosis of kidney disease within 90 days after the first administration of cisplatin was the study outcome...
2017: Journal of Cancer
Ming-Shao Tsai, Meng-Hung Lin, Chuan-Pin Lee, Yao-Hsu Yang, Wen-Cheng Chen, Geng-He Chang, Yao-Te Tsai, Pau-Chung Chen, Ying-Huang Tsai
BACKGROUND: The Chang Gung Research Database (CGRD) is a de-identified database derived from original medical records of Chang Gung Memorial Hospital (CGMH), which comprises seven medical institutes located from the northeast to southern regions of Taiwan. The volume of medical services performed in CGMH is large, and clinical and scientific studies based on the CGRD are reported to be of high quality. However, the CGRD as a useful database for research has not been analyzed before. The objective of the study was to analyze the CGRD with regard to its characteristics and coverage of Taiwan's population...
October 2017: Biomedical Journal
Kai-Chieh Chan, Yao-Te Tsai, Yao-Hsu Yang, Pau-Chung Chen, Po-Hung Chang
Recent evidence has indicated that osteoporosis is a risk factor for benign paroxysmal positional vertigo (BPPV). This large population-based study demonstrated that patients with osteoporosis had a 1.82-fold higher risk of developing BPPV than those without osteoporosis through the use of the Taiwan National Health Insurance Research Database. PURPOSE: Benign paroxysmal positional vertigo (BPPV) is one of the most frequent causes of vertigo. Osteoporosis reflects a homeostatic imbalance in the rate of bone turnover, with the rate of bone resorption exceeding that of bone formation...
November 25, 2017: Archives of Osteoporosis
Jing-Quan Zheng, Hui-Ju Lai, Cai-Mei Zheng, Yu-Chun Yen, Kuo-Cheng Lu, Chaur-Jong Hu, Hsun-Hua Lee, Yuan-Hung Wang
Stroke is a critical issue of physical disability. This study aimed to investigate the association of stroke subtypes and hip fracture by using the Taiwan National Health Insurance Research Database. Significantly higher risks of hip fracture were found for female gender and intracerebral hemorrhagic stroke patients. INTRODUCTION: Previous studies reported the increased hip fracture (HF) after acute stroke. Increased falling tendency immobilization-related sarcopenia and underlying comorbidities are related to HF in stroke patients...
November 22, 2017: Archives of Osteoporosis
Ming-Yen Tsai, Wen-Long Hu, Jen-Huai Chiang, Yu-Chuen Huang, Shih-Yu Chen, Yu-Chiang Hung, Yung-Hsiang Chen
Background: No previous studies have evaluated the effects of traditional Chinese medicine (TCM) treatment on patients with heart failure (HF). Hence, in this study, we determined whether TCM treatment affects the healthcare burden and survival of HF patients. Methods: Samples were retrieved from the registry of catastrophic illness patients of the Taiwan National Health Insurance Research Database (NHIRD). Based on a frequency (1:1) matched case-control design, patients with HF between 2000 and 2010 were designated as cases (TCM users) and controls (non-TCM users)...
October 27, 2017: Oncotarget
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