keyword
MENU ▼
Read by QxMD icon Read
search

cprd

keyword
https://www.readbyqxmd.com/read/28716794/incidence-of-live-attenuated-influenza-vaccine-administration-beyond-expiry-date-in-children-and-adolescents-aged-2-17-years-in-the-uk-a-population-based-cohort-study
#1
Herve Caspard, Robert P Wise, Amy Steffey, Robert S Brody
OBJECTIVES: To estimate the proportion of live-attenuated influenza vaccine (LAIV) doses administered beyond expiry date in children and adolescents during influenza seasons 2013-2014 and 2014-2015 in the UK. DESIGN: This was a retrospective cohort study. Two cohorts of children and adolescents who received LAIV from 1 September 2013 to 31 March 2014 and from 1 September 2014 to 31 March 2015 and aged 2-17 years at time of LAIV administration were identified from the Clinical Practice Research Datalink (CPRD)...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28708856/diabetes-use-of-metformin-and-the-risk-of-meningioma
#2
Corinna Seliger, Christoph R Meier, Claudia Becker, Susan S Jick, Martin Proescholdt, Ulrich Bogdahn, Peter Hau, Michael F Leitzmann
BACKGROUND: Metformin is a commonly used oral antidiabetic agent that has been associated with decreased cancer risk. However, data regarding the association between metformin use and the risk of meningioma are unavailable. METHODS: We conducted a matched case-control analysis using data from the U.K.-based Clinical Practice Research Datalink (CPRD) to analyse diabetes status, duration of diabetes, glycemic control, and use of metformin, sulfonylureas, and insulin in relation to the risk of meningioma...
2017: PloS One
https://www.readbyqxmd.com/read/28695564/iron-supplementation-in-switzerland-a-bi-national-descriptive-and-observational-study
#3
Fabienne A Biétry, Balthasar Hug, Oliver Reich, Jick S Susan, Christoph Rudolf Meier
BACKGROUND: Iron deficiency is the most common nutritional disorder in the world, and it is the only common nutrient deficiency in industrialised nations. It is thought to be the most common cause of anaemia. Use of iron supplementation in Switzerland has not been previously quantified in detail. OBJECTIVES: We quantified use of iron supplementation from Swiss data and compared it with data from the UK. We assessed the frequency of serum ferritin and haemoglobin tests prior to newly started iron therapy to see whether use was based on documented low iron levels or blood parameters, especially in the case of parenteral iron supplementation...
July 11, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28693298/chicken-rna-binding-protein-tia-1-contributes-to-stress-granule-formation-in-chicken-cells-and-tissues
#4
Yingjie Sun, Pin Zhang, Hang Zheng, Luna Dong, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao, Chunchun Meng, Shengqing Yu, Chan Ding
T-cell internal antigen-1 (TIA-1) plays roles in regulating alternative pre-mRNA splicing, mRNA translation, and stress granule (SG) formation in human cells. As an evolutionarily conserved response to environmental stress, SG has been reported to exist in various species. However, SG formation in chicken cells and the role of chicken TIA-1 (cTIA-1) in SG assembly has not been elucidated. In the present study, we cloned cTIA-1 and showed that cTIA-1 facilitates in the assembly of canonical SGs in both human and chicken cells...
July 10, 2017: Journal of Veterinary Science
https://www.readbyqxmd.com/read/28679541/alcohol-consumption-and-all-cause-mortality-an-analysis-of-general-practice-database-records-for-patients-with-long-term-conditions
#5
Duncan Stewart, Lu Han, Tim Doran, Jim McCambridge
BACKGROUND: Alcohol is a risk factor for ill health and reduced life expectancy, but little is known about the impact of alcohol on mortality for people with existing long-term conditions. We used primary care data from the Clinical Practice Research Datalink (CPRD) to study relationships between alcohol consumption and all-cause mortality among general practice patients with long-term conditions. METHODS: Data were accessed from a sample of 125 general practices from the CPRD database...
July 5, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28656132/cost-effectiveness-of-antibiotics-for-copd-management-observational-analysis-using-cprd-data
#6
Sarah J Ronaldson, Anan Raghunath, David J Torgerson, Tjeerd Van Staa
It is often difficult to determine the cause of chronic obstructive pulmonary disease (COPD) exacerbations, and antibiotics are frequently prescribed. This study conducted an observational cost-effectiveness analysis of prescribing antibiotics for exacerbations of COPD based on routinely collected data from patient electronic health records. A cohort of 45 375 patients aged 40 years or more who attended their general practice for a COPD exacerbation during 2000-2013 was identified from the Clinical Practice Research Datalink...
April 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28652719/validity-and-interpretation-of-spirometric-recordings-to-diagnose-copd-in-uk-primary-care
#7
Kieran J Rothnie, Joht S Chandan, Harry G Goss, Hana Müllerová, Jennifer K Quint
BACKGROUND: The diagnosis of COPD is dependent upon clinical judgment and confirmation of the presence of airflow obstruction using spirometry. Spirometry is now routinely available; however, spirometry incorrectly performed or interpreted can lead to misdiagnosis. We aimed to determine whether spirometry undertaken in primary care for patients suspected to have COPD was of sufficient quality and whether their spirometry was correctly interpreted. METHODS: Two chest physicians re-read all spirometric readings for both quality of the procedure and interpretation, received as a part of COPD validation studies using data from the Clinical Practice Research Datalink (CPRD)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28614231/incidence-prevalence-and-natural-history-of-primary-sclerosing-cholangitis-in-the-united-kingdom
#8
Huifang Liang, Sudhakar Manne, Jesse Shick, Trevor Lissoos, Paul Dolin
Primary sclerosing cholangitis (PSC) is a rare obliterative fibrotic condition of the bile ducts. We assessed PSC epidemiology and natural history within the UK Clinical Practice Research Datalink (CPRD).Incidence and natural history of PSC were evaluated in a retrospective cohort study using linkage of CPRD, Hospital Episode Statistics, and Office for National Statistics data. Data from age, sex, and general practice-matched population controls provided a context for the incident PSC patients. Liver disease other than PSC was defined as autoimmune hepatitis, hepatitis, hepatomegaly, liver failure, cirrhosis, portal hypertension, cholangiocarcinoma, or hepatobiliary cancer...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28608143/resource-utilization-among-glaucoma-patients-in-the-uk-treated-with-beta-blocker-and-non-beta-blocker-adjunctive-therapy-a-retrospective-cohort-analysis
#9
Ananth Viswanathan, Claudio Spera, Anmol Mullins, David Covert, Judit Banhazi, Paul McDwyer, Eibhlin Hudson, Alberto Ferreira
INTRODUCTION: Few studies have examined outcomes and potential complications among glaucoma patients who are prescribed topical beta-blockers. This study examined resource usage (number of GP visits and hospitalizations) and diagnoses of respiratory or cardiovascular conditions among glaucoma patients prescribed beta-blockers compared to patients not prescribed beta-blockers. METHODS: A retrospective cohort analysis was conducted using data from the UK Clinical Practice Research Datalink (CPRD) database over the period January 1, 2006 to March 31, 2014...
May 30, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28598998/financial-incentives-improve-recognition-but-not-treatment-of-cardiovascular-risk-factors-in-severe-mental-illness
#10
Carol L Wilson, Kirsty M Rhodes, Rupert A Payne
OBJECTIVES: Severe mental illness (SMI) is associated with premature cardiovascular disease, prompting the UK primary care payment-for-performance system (Quality and Outcomes Framework, QOF) to incentivise annual physical health reviews. This study aimed to assess the QOF's impact on detection and treatment of cardiovascular risk factors in people with SMI. METHODS: A retrospective open cohort study of UK general practice was conducted between 1996 and 2014, using segmented logistic regression with 2004 and 2011 as break points, reflecting the introduction of relevant QOF incentives in these years...
2017: PloS One
https://www.readbyqxmd.com/read/28571893/selective-serotonin-reuptake-inhibitors-and-cataract-risk-a-case-control-analysis
#11
Claudia Becker, Susan S Jick, Christoph R Meier
PURPOSE: Use of selective serotonin reuptake inhibitors (SSRIs) has been associated with an increased cataract risk. We aimed to assess cataract risk after exposure to SSRI or to other antidepressant drugs in a large electronic primary care database. DESIGN: Case-control study. PARTICIPANTS: The study population was derived from the UK-based Clinical Practice Research Datalink (CPRD). We included patients with first-time cataract aged ≥40 years between 1995 and 2015 and an equal number of cataract-free controls matched on age, sex, general practice, date of cataract recording (i...
May 29, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28476151/health-care-resource-use-by-patients-before-and-after-a-diagnosis-of-chronic-fatigue-syndrome-cfs-me-a-clinical-practice-research-datalink-study
#12
Simon M Collin, Inger J Bakken, Irwin Nazareth, Esther Crawley, Peter D White
BACKGROUND: Our aim was to investigate patterns of health care resource use by patients before and after a diagnosis of CFS/ME, as recorded by Clinical Practice Research Datalink (CPRD) GP practices in the UK. METHODS: We used a case-control study design in which patients who had a first recorded diagnosis of CFS/ME during the period 01/01/2001 to 31/12/2013 were matched 1:1 with controls by age, sex, and GP practice. We compared rates of GP consultations, diagnostic tests, prescriptions, referrals, and symptoms between the two groups from 15 years (in adults) or 10 years (in children) before diagnosis to 10 years after diagnosis...
May 5, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28469154/risk-of-infections-in-patients-with-gout-a-population-based-cohort-study
#13
B Spaetgens, F de Vries, J H M Driessen, H G Leufkens, P C Souverein, A Boonen, J W M van der Meer, L A B Joosten
To investigate the risk of various types of infections (pneumonia and urinary tract infection (UTI)), and infection-related mortality in patients with gout compared with population-based controls. A retrospective cohort study was conducted using data from the UK Clinical Practice Research Datalink (CPRD). All patients with a first diagnosis of gout and aged >40 years between January 1987-July 2014, were included and matched with up to two controls. Time-varying Cox proportional hazards models were used to estimate the risk of infections and mortality...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28463961/herpes-zoster-risk-after-21-specific-cancers-population-based-case-control-study
#14
Erik Hansson, Harriet J Forbes, Sinéad M Langan, Liam Smeeth, Krishnan Bhaskaran
BACKGROUND: Some malignancies are known to be associated with increased risk of herpes zoster, but little is known about how associations between cancer and subsequent zoster risk vary by cancer site, by time since cancer diagnosis, and by age. METHODS: An age-, sex-, calendar time-, and practice-matched case-control study, nested in the broadly UK representative Clinical Practice Research Datalink (CPRD) primary care database, was analysed using conditional logistic regression to estimate the association between 21 of the most common specific malignancies and subsequent zoster risk...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28455344/temporal-trends-in-incidence-prevalence-and-mortality-of-atrial-fibrillation-in-primary-care
#15
Deirdre A Lane, Flemming Skjøth, Gregory Y H Lip, Torben B Larsen, Dipak Kotecha
BACKGROUND: Incidence and prevalence of atrial fibrillation (AF) are expected to increase dramatically; however, we currently lack comprehensive data on temporal trends in unselected clinical populations. METHODS AND RESULTS: Analysis of the UK Clinical Practice Research Datalink (CPRD) from 1998 to 2010 of patients with incident AF, excluding major valvular disease, linked to hospital admission data and national statistics. Fifty-seven thousand eight hundred eighteen adults were identified with mean age 74...
April 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28451867/prevalence-and-incidence-trends-for-diagnosed-prescription-opioid-use-disorders-in-the-united-kingdom
#16
Andrew J M Cooper, Jenna Willis, Janice Fuller, Heike Benecke, James Leighton-Scott, Frank Andersohn, Joseph Kim, Christoph Maier, Roger D Knaggs
INTRODUCTION: The prevalence of prescription opioid use disorders in the US has increased markedly in parallel with increases in opioid prescribing. Whilst an increase in opioid prescribing has also occurred in the UK, it remains unknown if there have been concurrent increases in opioid use disorders. The aim of this study was to examine national trends in the prevalence and incidence of physician-diagnosed opioid use disorders in the UK. METHODS: In a retrospective electronic health care database analysis using data from the UK Clinical Practice Research Datalink (CPRD), we identified persons receiving a first opioid prescription between January 1, 2008 and December 31, 2012...
June 2017: Pain and Therapy
https://www.readbyqxmd.com/read/28387052/examining-trends-in-type-2-diabetes-incidence-prevalence-and-mortality-in-the-uk-between-2004-and-2014
#17
Salwa S Zghebi, Douglas T Steinke, Matthew J Carr, Martin K Rutter, Richard A Emsley, Darren M Ashcroft
AIMS: Contemporary data describing type 2 diabetes prevalence, incidence and mortality are limited. We aimed to (i) estimate annual incidence and prevalence rates of type 2 diabetes in the UK between 2004 and 2014; (ii) examine relationships between observed rates with age, gender, socio-economic status and geographic region; and (iii) assess how temporal changes in incidence and all-cause mortality rates influence changes in prevalence. METHODS: Type 2 diabetes cases aged ≥16 years between January 2004 and December 2014 were identified using the Clinical Practice Research Datalink (CPRD)...
April 7, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28362848/epidemiology-of-alcohol-dependence-in-uk-primary-care-results-from-a-large-observational-study-using-the-clinical-practice-research-datalink
#18
Andrew Thompson, Alison K Wright, Darren M Ashcroft, Tjeerd P van Staa, Munir Pirmohamed
This study aims to investigate the incidence and annual presentation rates of alcohol dependence in general practice in the UK, and examine age-, gender-, socioeconomic-, and region-specific variation. We conducted a retrospective 'open' cohort study using the Clinical Practice Research Datalink (CPRD), an anonymised primary care database. Prior to data extraction, a case definition for alcohol dependence in CPRD was established using 47 Read codes, which included primary alcohol dependence and consequences of alcohol dependence...
2017: PloS One
https://www.readbyqxmd.com/read/28360235/venous-thromboembolism-in-adults-screened-for-sickle-cell-trait-a-population-based-cohort-study-with-nested-case-control-analysis
#19
Iain Little, Yana Vinogradova, Elizabeth Orton, Joe Kai, Nadeem Qureshi
OBJECTIVE: To determine whether sickle cell carriers ('sickle cell trait') have an increased risk of venous thromboembolism (VTE). DESIGN: Cohort study with nested case-control analysis. SETTING: General population with data from 609 UK general practices in the Clinical Practice Research Datalink (CPRD). PARTICIPANTS: All individuals registered with a CPRD general practice between 1998 and 2013, with a medical record of screening for sickle cell between 18 and 75 years of age...
March 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28358988/trends-in-the-incidence-of-chronic-fatigue-syndrome-and-fibromyalgia-in-the-uk-2001-2013-a-clinical-practice-research-datalink-study
#20
Simon M Collin, Inger J Bakken, Irwin Nazareth, Esther Crawley, Peter D White
Objective Trends in recorded diagnoses of chronic fatigue syndrome (CFS, also known as 'myalgic encephalomyelitis' (ME)) and fibromyalgia (FM) in the UK were last reported more than ten years ago, for the period 1990-2001. Our aim was to analyse trends in incident diagnoses of CFS/ME and FM for the period 2001-2013, and to investigate whether incidence might vary by index of multiple deprivation (IMD) score. Design Electronic health records cohort study. Setting NHS primary care practices in the UK. Participants Participants: Patients registered with general practices linked to the Clinical Practice Research Datalink (CPRD) primary care database from January 2001 to December 2013...
June 2017: Journal of the Royal Society of Medicine
keyword
keyword
51806
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"