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https://www.readbyqxmd.com/read/29331994/acl-and-meniscal-injuries-increase-the-risk-of-primary-total-knee-replacement-for-osteoarthritis-a-matched-case-control-study-using-the-clinical-practice-research-datalink-cprd
#1
Tanvir Khan, Abtin Alvand, Daniel Prieto-Alhambra, David J Culliford, Andrew Judge, William F Jackson, Brigitte E Scammell, Nigel K Arden, Andrew James Price
OBJECTIVES: The aim of this study was to investigate whether ACL injury (ACLi) or meniscal injury increases the risk of end-stage osteoarthritis (OA) resulting in total knee replacement (TKR). METHODS: A matched case-control study of all TKRs performed in the UK between January 1990 and July 2011 and recorded in the Clinical Practice Research Datalink (CPRD) was undertaken. The CPRD contains longitudinal data on approximately 3.6 million patients. Two controls were selected for each case of TKR, matched on age, sex and general practitioner location as a proxy for socioeconomic status...
January 13, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29250905/validity-of-diagnostic-codes-to-identify-hospitalizations-for-infections-among-patients-treated-with-oral-anti-diabetic-drugs
#2
M Elle Saine, Mona Gizaw, Dena M Carbonari, Craig W Newcomb, Jason A Roy, Serena Cardillo, Daina B Esposito, Harshvinder Bhullar, Arlene M Gallagher, Brian L Strom, Vincent Lo Re
PURPOSE: Identification of hospitalizations for infection is important for post-marketing surveillance of drugs, but the validity of using diagnosis codes to identify these events is unknown. Differentiating between hospitalization for and with infection is important, as the latter is common and less likely to arise from pre-admission exposure to drugs. We determined positive predictive values (PPVs) of diagnostic coding-based algorithms to identify hospitalization for infection among patients prescribed oral anti-diabetic drugs (OADs)...
December 18, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29218780/under-treatment-of-hypertension-and-hypercholesterolemia-in-children-and-adolescents-with-type-1-diabetes-long-term-follow-up-on-time-trends-in-the-occurrence-of-cardiovascular-disease-risk-factors-and-medications-use
#3
Fariba Ahmadizar, Patrick Souverein, Anthonius de Boer, Anke H Maitland-van der Zee
AIMS: 1) To evaluate long-term trends in the occurrence and treatment of cardiovascular disease (CVD) risk factors and occurrence of CVD events in children with type 1 diabetes mellitus (T1DM), and 2) To assess determinants of under-treatment of CVD risk factors. METHODS: A retrospective cohort study was conducted in 3,728 children (<19 years) with T1DM and up to 5 age and gender-matched diabetes-free children (reference cohort) (n=18,513) using data from the Clinical Practice Research Datalink (CPRD)...
December 7, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29208621/retrospective-multicohort-analysis-of-the-clinical-practice-research-datalink-cprd-to-determine-differences-in-the-cost-of-medication-wastage-dispensing-fees-and-prescriber-time-of-issuing-either-short-60-days-or-long-%C3%A2-60-days-prescription-lengths-in-primary
#4
Brett Doble, Rupert Payne, Amelia Harshfield, Edward C F Wilson
OBJECTIVES: To investigate patterns of early repeat prescriptions and treatment switching over an 11-year period to estimate differences in the cost of medication wastage, dispensing fees and prescriber time for short (<60 days) and long (≥60 days) prescription lengths from the perspective of the National Health Service in the UK. SETTING: Retrospective, multiple cohort study of primary care prescriptions from the Clinical Practice Research Datalink. PARTICIPANTS: Five random samples of 50 000 patients each prescribed oral drugs for (1) glucose control in type 2 diabetes mellitus (T2DM); (2) hypertension in T2DM; (3) statins (lipid management) in T2DM; (4) secondary prevention of myocardial infarction; and (5) depression...
December 4, 2017: BMJ Open
https://www.readbyqxmd.com/read/29199359/risk-of-venous-thromboembolism-among-users-of-different-anti-osteoporosis-drugs-a-population-based-cohort-analysis-including-over-200-000-participants-from-spain-and-the-uk
#5
E Martín-Merino, I Petersen, S Hawley, A Álvarez-Gutierrez, S Khalid, A Llorente-Garcia, A Delmestri, M K Javaid, T P Van Staa, A Judge, C Cooper, D Prieto-Alhambra
The venous thromboembolism risk among anti-osteoporotics is unknown. In this primary care study, the risk with other bisphosphonates [1.05 (0.94-1.18) and 0.96 (0.78-1.18)], strontium [0.90 (0.61-1.34) and 1.19 (0.82-1.74)], in the UK and Spain respectively, and denosumab [1.77 (0.25-12.66)] and teriparatide [1.27 (0.59-2.71)] in Spain, did not differ versus alendronate. INTRODUCTION: Most of the known adverse drug reactions described for anti-osteoporosis medication (AOM) have been described in studies comparing AOM users to non-users...
December 3, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29193554/do-delays-in-data-availability-limit-the-implementation-of-near-real-time-vaccine-safety-surveillance-using-the-clinical-practice-research-datalink
#6
Andreia Leite, Sara L Thomas, Nick J Andrews
PURPOSE: Near real-time vaccine safety surveillance (NRTVSS) using electronic health records has been used to detect timely vaccine safety signals. Trial implementation of NRTVSS using the Clinical Practice Research Datalink (CPRD) has shown that there is limited power to detect safety signals for rare events. Delays in recording outcomes and receiving data influence the power and timeliness to identify a signal. Our work aimed to compare how different sources of delays influence power and expected time to signal to implement NRTVSS using CPRD...
November 28, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29190680/identifying-social-factors-amongst-older-individuals-in-linked-electronic-health-records-an-assessment-in-a-population-based-study
#7
Anu Jain, Albert J van Hoek, Jemma L Walker, Rohini Mathur, Liam Smeeth, Sara L Thomas
Identification and quantification of health inequities amongst specific social groups is a pre-requisite for designing targeted healthcare interventions. This study investigated the recording of social factors in linked electronic health records (EHR) of individuals aged ≥65 years, to assess the potential of these data to identify the social determinants of disease burden and uptake of healthcare interventions. Methodology was developed for ascertaining social factors recorded on or before a pre-specified index date (01/01/2013) using primary care data from Clinical Practice Research Datalink (CPRD) linked to hospitalisation and deprivation data in a cross-sectional study...
2017: PloS One
https://www.readbyqxmd.com/read/29174292/temporal-trends-and-patterns-in-heart-failure-incidence-a-population-based-study-of-4-million-individuals
#8
Nathalie Conrad, Andrew Judge, Jenny Tran, Hamid Mohseni, Deborah Hedgecott, Abel Perez Crespillo, Moira Allison, Harry Hemingway, John G Cleland, John J V McMurray, Kazem Rahimi
BACKGROUND: Large-scale and contemporary population-based studies of heart failure incidence are needed to inform resource planning and research prioritisation but current evidence is scarce. We aimed to assess temporal trends in incidence and prevalence of heart failure in a large general population cohort from the UK, between 2002 and 2014. METHODS: For this population-based study, we used linked primary and secondary electronic health records of 4 million individuals from the Clinical Practice Research Datalink (CPRD), a cohort that is representative of the UK population in terms of age and sex...
November 21, 2017: Lancet
https://www.readbyqxmd.com/read/29171906/risk-of-a-first-ever-acute-myocardial-infarction-and-all-cause-mortality-with-sulphonylurea-treatment-a-population-based-cohort-study
#9
Judith van Dalem, Martijn C G J Brouwers, Coen D A Stehouwer, André Krings, Olaf H Klungel, Johanna H M Driessen, Frank de Vries, Andrea M Burden
We investigated the association between the current use of individual sulphonylureas and the risk of a first-ever acute myocardial infarction (AMI) and all-cause mortality, in a population-based cohort study, using primary care data from the Clinical Practice Research Datalink database (2004-2012). New users (N = 121 869), aged ≥18 years, with at least one prescription for a non-insulin antidiabetic agent were included. The first prescription defined start of follow-up. Time-dependent Cox proportional hazard models were used to estimate the risk of a first-ever AMI and all-cause mortality associated with the use of individual sulphonylureas, and other non-insulin glucose-lowering drugs...
November 24, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29170293/identifying-clinical-features-in-primary-care-electronic-health-record-studies-methods-for-codelist-development
#10
Jessica Watson, Brian D Nicholson, Willie Hamilton, Sarah Price
OBJECTIVE: Analysis of routinely collected electronic health record (EHR) data from primary care is reliant on the creation of codelists to define clinical features of interest. To improve scientific rigour, transparency and replicability, we describe and demonstrate a standardised reproducible methodology for clinical codelist development. DESIGN: We describe a three-stage process for developing clinical codelists. First, the clear definition a priori of the clinical feature of interest using reliable clinical resources...
November 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29150473/patient-level-and-practice-level-factors-associated-with-consultation-duration-a-cross-sectional-analysis-of-over-one-million-consultations-in-english-primary-care
#11
Sarah Stevens, Clare Bankhead, Toqir Mukhtar, Rafael Perera-Salazar, Tim A Holt, Chris Salisbury, F D Richard Hobbs
OBJECTIVES: Consultation duration has previously been shown to be associated with patient, practitioner and practice characteristics. However, previous studies were conducted outside the UK, considered only small numbers of general practitioner (GP) consultations or focused primarily on practitioner-level characteristics. We aimed to determine the patient-level and practice-level factors associated with duration of GP and nurse consultations in UK primary care. DESIGN AND SETTING: Cross-sectional data were obtained from English general practices contributing to the Clinical Practice Research Datalink (CPRD) linked to data on patient deprivation and practice staffing, rurality and Quality and Outcomes Framework (QOF) achievement...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29138197/incidence-of-shoulder-dislocations-in-the-uk-1995-2015-a-population-based-cohort-study
#12
Anjali Shah, Andrew Judge, Antonella Delmestri, Katherine Edwards, Nigel K Arden, Daniel Prieto-Alhambra, Tim A Holt, Rafael A Pinedo-Villanueva, Sally Hopewell, Sarah E Lamb, Amar Rangan, Andrew J Carr, Gary S Collins, Jonathan L Rees
OBJECTIVE: This cohort study evaluates the unknown age-specific and gender-specific incidence of primary shoulder dislocations in the UK. SETTING: UK primary care data from the Clinical Practice Research Datalink (CPRD) were used to identify patients aged 16-70 years with a shoulder dislocation during 1995-2015. Coding of primary shoulder dislocations was validated using the CPRD general practitioner questionnaire service. PARTICIPANTS: A cohort of 16 763 patients with shoulder dislocation aged 16-70 years during 1995-2015 were identified...
November 14, 2017: BMJ Open
https://www.readbyqxmd.com/read/29126386/venous-thromboembolism-and-mortality-in-breast-cancer-cohort-study-with-systematic-review-and-meta-analysis
#13
Umair T Khan, Alex J Walker, Sadaf Baig, Tim R Card, Cliona C Kirwan, Matthew J Grainge
BACKGROUND: Breast cancer patients are at an increased risk of venous thromboembolism (VTE). However, current evidence as to whether VTE increases the risk of mortality in breast cancer patients is conflicting. We present data from a large cohort of patients from the UK and pool these with previous data from a systematic review. METHODS: Using the Clinical Practice Research Datalink (CPRD) dataset, we identified a cohort of 13,202 breast cancer patients, of whom 611 were diagnosed with VTE between 1997 and 2006 and 12,591 did not develop VTE...
November 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29121851/outputs-and-growth-of-primary-care-databases-in-the-united-kingdom-bibliometric-analysis
#14
Zain Chaudhry, Fahmida Mannan, Angela Gibson-White, Usama Syed, Shirin Ahmed, Antonis Kousoulis, Azeem Majeed
BACKGROUND: Electronic health database (EHD) data is increasingly used by researchers. The major United Kingdom EHDs are the 'Clinical Practice Research Datalink' (CPRD), 'The Health Improvement Network' (THIN) and 'QResearch'. Over time, outputs from these databases have increased, but have not been evaluated. OBJECTIVE: This study compares research outputs from CPRD, THIN and QResearch assessing growth and publication outputs over a 10-year period (2004-2013)...
October 17, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/29114849/risk-of-skin-cancer-among-patients-with-myotonic-dystrophy-type-1-based-on-primary-care-physician-data-from-the-united-kingdom-clinical-practice-research-datalink
#15
Youjin Wang, Ruth M Pfeiffer, Rotana Alsaggaf, Wilhelmine Meeraus, Julia C Gage, Lesley A Anderson, Renée C Bremer, Nikoletta Nikolenko, Hanns Lochmuller, Mark H Greene, Shahinaz M Gadalla
Myotonic dystrophy type 1 (DM1) is an inherited multisystem neuromuscular disorder caused by a CTG trinucleotide repeat expansion in the DMPK gene. Recent evidence documents that DM1 patients have an increased risk of certain cancers, but whether skin cancer risks are elevated is unclear. Using the U.K. Clinical Practice Research Datalink (CPRD), we identified 1,061 DM1 patients and 15,119 DM1-free individuals matched on gender, birth year (±2 years), attending practice, and registration year (±1 year). We calculated the hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of DM1 diagnosis with skin cancer risk using Cox proportional hazards models, for all skin cancers combined and by histological subtype...
November 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29094346/population-based-clinical-practice-research-datalink-study-using-algorithm-modelling-to-identify-the-true-burden-of-hidradenitis-suppurativa
#16
J R Ingram, S Jenkins-Jones, D W Knipe, C L I Morgan, R Cannings-John, V Piguet
BACKGROUND: Epidemiology data regarding hidradenitis suppurativa (HS) are conflicting and prevalence estimates vary 80-fold, from 0.05% in a population-based study, to 4%. OBJECTIVES: To assess the hypothesis that previous population-based studies under-estimated true HS prevalence by missing undiagnosed cases. METHODS: We performed a population-based observational and case-control study using the UK Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics data...
November 1, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29081921/creating-an-index-to-measure-health-state-of-depressed-patients-in-automated-healthcare-databases-the-methodology
#17
Clément François, Adrian Tanasescu, François-Xavier Lamy, Nicolas Despiegel, Bruno Falissard, Ylana Chalem, Christophe Lançon, Pierre-Michel Llorca, Delphine Saragoussi, Patrice Verpillat, Alan G Wade, Djamel A Zighed
Background and objective: Automated healthcare databases (AHDB) are an important data source for real life drug and healthcare use. In the filed of depression, lack of detailed clinical data requires the use of binary proxies with important limitations. The study objective was to create a Depressive Health State Index (DHSI) as a continuous health state measure for depressed patients using available data in an AHDB. Methods: The study was based on historical cohort design using the UK Clinical Practice Research Datalink (CPRD)...
2017: Journal of Market Access & Health Policy
https://www.readbyqxmd.com/read/29065729/factors-associated-with-stroke-myocardial-infarction-ischemic-heart-disease-unstable-angina-or-mortality-in-patients-from-real-world-clinical-practice-with-newly-diagnosed-type-2-diabetes-and-early-glycemic-control
#18
Carlos I Alatorre, Byron J Hoogwerf, Mark A Deeg, David R Nelson, Theresa M Hunter, Wee Teck Ng, Mark D Rekhter
OBJECTIVES: The objective of this study was to identify factors associated with stroke, myocardial infarction (MI), all-cause mortality, or a diagnosis of ischemic heart disease (IHD) or unstable angina (UA), among patients newly-diagnosed with type 2 diabetes (T2DM) with no recent history of cardiovascular (CV) events who rapidly achieve and maintain HbA1c ≤8.0%. METHODS: Data were obtained from the Clinical Practice Research Datalink (CPRD) from January 1990 to December 2012...
November 24, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29056424/implementing-near-real-time-vaccine-safety-surveillance-using-the-clinical-practice-research-datalink-cprd
#19
Andreia Leite, Sara L Thomas, Nick J Andrews
INTRODUCTION: Near real-time vaccine safety surveillance (NRTVSS) using electronic health records is increasingly used to rapidly detect vaccine safety signals. NRTVSS has not been fully implemented in the UK. We assessed the feasibility of implementing this surveillance using the UK Clinical Practice Research Datalink (CPRD). METHODS: We selected seasonal influenza vaccine/Guillain-Barré Syndrome (GBS) as an example of a rare outcome and measles-mumps-rubella (MMR) vaccine/febrile seizures as a positive control...
October 19, 2017: Vaccine
https://www.readbyqxmd.com/read/29055489/association-between-nice-guidance-on-biologic-therapies-with-rates-of-hip-and-knee-replacement-among-rheumatoid-arthritis-patients-in-england-and-wales-an-interrupted-time-series-analysis
#20
Samuel Hawley, René Cordtz, Lene Dreyer, Christopher J Edwards, Nigel K Arden, Antonella Delmestri, Alan Silman, Cyrus Cooper, Andrew Judge, Daniel Prieto-Alhambra
OBJECTIVE: To estimate the impact of NICE approval of tumor necrosis factor inhibitor (TNFi) therapies on the incidence of total hip replacement (THR) and total knee replacement (TKR) among rheumatoid arthritis (RA) patients in England and Wales. METHODS: Primary care data [Clinical Practice Research Datalink (CPRD)] for the study period (1995-2014) were used to identify incident adult RA patients. The age and sex-standardised 5-year incidence of THR and TKR was calculated separately for RA patients diagnosed in each six-months between 1995-2009...
September 23, 2017: Seminars in Arthritis and Rheumatism
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