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Intraesophageal pH

M M J Singendonk, J M Oors, A J Bredenoord, T I Omari, R J van der Pol, M J Smits, M A Benninga, M P van Wijk
BACKGROUND: Rumination syndrome is characterized by recurrent regurgitation of recently ingested food into the mouth. Differentiation with other diagnoses and gastroesophageal reflux disease (GERD) in particular, is difficult. Recently, objective pH-impedance (pH-MII) and manometry criteria were proposed for adults. The aim of this study was to determine diagnostic ambulatory pH-MII and manometry criteria for rumination syndrome in children. METHODS: Clinical data and 24-hour pH-MII and manometry recordings of children with a clinical suspicion of rumination syndrome were reviewed...
May 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Serhat Bor, Askin Erdogan, Berna Bayrakci, Esra Yildirim, Rukiye Vardar
Obesity increases the risk of gastroesophageal reflux disease (GERD). The majority of the reflux attacks occur postprandially. The influence of the speed of food intake on gastroesophageal reflux events is unclear in obese patients. To determine the influence of the speed of food intake on intraesophageal reflux events in obese patients with and without GERD. A total of 26 obese female patients were recruited. The patients underwent esophageal manometry to evaluate the upper limit of the lower esophageal sphincter and subsequently placement of a Multichannel intraluminal impedance-pH (MII-pH) catheter...
January 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
G S Dzhulay, E V Sekareva
AIM: To estimate esophageal and gastric pH values on an empty stomach and after stimulation of gastric secretion and gastric and duodenal motor-evacuatory activity in patients with gastroesophageal reflux disease (GERD) associated with pathological refluxes, such as gastroesophageal reflux (GER) and duodenogastroesophageal reflux (DGER). SUBJECTS AND METHODS: The observational cross-sectional study was conducted to investigate and compare the parameters of intraesophageal and intragastric pH metry and peripheral electrogastroenterography in 103 GERD patients with endoscopically positive distal reflux esophagitis in GER and DGER...
2016: Terapevticheskiĭ Arkhiv
Mitsushige Sugimoto, Tomohiko Hasegawa, Masafumi Nishino, Shu Sahara, Takahiro Uotani, Hitomi Ichikawa, Takuma Kagami, Ken Sugimoto, Yu Yamato, Daisuke Togawa, Sho Kobayashi, Hironobu Hoshino, Yukihiro Matsuyama, Takahisa Furuta
BACKGROUND AND AIM: Spinal kyphotic deformity occasionally results in gastroesophageal reflux disease (GERD). The effects of acid reflux on the esophagus in kyphotic patients are unclear, however, and it is unknown whether acid reflux, endoscopic GERD, and reflux-related symptoms improve following surgical spinal correction in these patients. Herein, we investigated the characteristics of GERD in kyphotic patients and the improvement in GERD following surgical correction. METHODS: In 48 patients with severe kyphotic deformity scheduled for surgical spinal correction, we conducted esophagogastroduodenoscopy, 24-h pH monitoring and three questionnaire surveys, including the frequency scale for the symptoms of GERD (FSSG)...
January 2016: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Taher Omari, Geoffrey Davidson, Patrik Bondarov, Emma Nauclér, Catarina Nilsson, Per Lundborg
OBJECTIVES: To evaluate the pharmacokinetics and acid-suppressive effects of esomeprazole in infants with gastroesophageal reflux disease (GERD). PATIENTS AND METHODS: In this single-blind, randomized, parallel-group study, 50 infants 1 to 24 months old with symptoms of GERD, and ≥ 5% of time with intraesophageal pH <4 during 24-hour dual pH monitoring, received oral esomeprazole 0.25 mg/kg (n = 26) or 1 mg/kg (n = 24) once daily for 1 week. Intraesophageal and intragastric pH were recorded at 1 week, and blood samples were taken for pharmacokinetic analysis...
July 2015: Journal of Pediatric Gastroenterology and Nutrition
Yasuhiro Tamura, Yasushi Funaki, Shinya Izawa, Akihito Iida, Yoshiharu Yamaguchi, Kazunori Adachi, Naotaka Ogasawara, Makoto Sasaki, Hiroshi Kaneko, Kunio Kasugai
AIM: To investigate the pathophysiology of functional heartburn (FH) in Japanese patients. METHODS: A total of 111 patients with proton pump inhibitor (PPI)-refractory non-erosive gastroesophageal reflux disease underwent intraesophageal pressure testing and 24-h multichannel intraluminal impedance-pH (24MII-pH) testing. The patients also completed several questionnaires while they were receiving the PPI treatment, including the questionnaire for the diagnosis of reflux disease (QUEST), the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG), the gastrointestinal symptoms rating scale (GSRS), SF-36, and the Cornell Medical Index (CMI)...
April 28, 2015: World Journal of Gastroenterology: WJG
Harathi Yandrapu, Marek Marcinkiewicz, Cezary Poplawski, Kyung Han, Tomasz Zbroch, George Goldin, Irene Sarosiek, Zbigniew Namiot, Jerzy Sarosiek
BACKGROUND: It has been previously demonstrated that patients with reflux esophagitis exhibit a significant impairment in the secretion of salivary protective components versus controls. However, the secretion of salivary protective factors in patients with nonerosive reflux disease (NERD) is not explored. The authors therefore studied the secretion of salivary volume, pH, bicarbonate, nonbicarbonate glycoconjugate, protein, epidermal growth factor (EGF), transforming growth factor alpha (TGF-α) and prostaglandin E2 in patients with NERD and compared with the corresponding values in controls (CTRL)...
May 2015: American Journal of the Medical Sciences
Serhat Bor, Elen Valytova, Suna Yapali, Esra Yildirim, Rukiye Vardar
BACKGROUND: The role of sexual activity on gastroesophageal reflux disease (GERD) is an under-recognized concern of patients, and one rarely assessed by physicians. OBJECTIVE: The objective of this article is to determine the influence of sexual activity on the intraesophageal acid exposure and acid reflux events in GERD patients. METHODS: Twenty-one patients with the diagnosis of GERD were prospectively enrolled. Intraesophageal pH monitoring was recorded for 48 hours with a Bravo capsule...
December 2014: United European Gastroenterology Journal
Lars Lundell, Jan Hatlebakk, Jean-Paul Galmiche, Stephen E Attwood, Christian Ell, Roberto Fiocca, Tore Persson, Péter Nagy, Stefan Eklund, Tore Lind
OBJECTIVE: To assess the long-term effect on symptoms and quality of life of esomeprazole 20 mg once daily, a recommended dose for maintenance therapy of gastroesophageal reflux disease (GERD). RESEARCH DESIGN AND METHODS: This is a post hoc analysis of 5 year data from patients in the LOTUS trial ( identifier: NCT00251927) who were randomized to esomeprazole 20 mg once daily. All participants had chronic, symptomatic GERD responsive to treatment...
January 2015: Current Medical Research and Opinion
R Rosen, J Amirault, N Heinz, H Litman, U Khatwa
BACKGROUND: One of the primary indications for reflux testing with multichannel intraluminal impedance with pH (pH-MII) is to correlate reflux events with symptoms such as cough. Adult and pediatric studies have shown, using cough as a model, that patient report of symptoms is inaccurate. Unfortunately, intraesophageal pressure recording (IEPR) to record coughs is more invasive which limits its utility in children. The primary aim of this study was to validate the use of acoustic cough recording (ACR) during pH-MII testing...
November 2014: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Harathi Yandrapu, Marek Marcinkiewicz, Cezary Poplawski, Zbigniew Namiot, Tomasz Zbroch, Jerzy Sarosiek
PURPOSE: A significantly compromised epidermal growth factor (EGF) secretion by basal parotid saliva may contribute to the development of Barrett's esophagus (BE). The rate of secretion of EGF as well as a wide spectrum of protective factors in total basal and stimulated saliva in BE patients remains to be explored. We therefore studied the rate of secretion of salivary buffers, glycoconjugate, protein, EGF, transforming growth factor α (TGFα) and prostaglandin E₂ (PGE₂), evoked by esophago-salivary reflex, in patients with BE and controls (CTRL)...
September 2014: Advances in Medical Sciences
J A Ramírez-Mayans, E M Toro-Monjaraz, J Romero-Trujillo, R Cervantes-Bustamante, F Zárate-Mondragón, E Montijo-Barrios, J Cadena-León, M Cazares-Méndez
BACKGROUND: Cow's milk protein allergy (CMPA) is being seen more frequently on a daily basis in pediatric consultations. It shares symptoms with gastroesophageal reflux (GER), which can complicate the differential diagnosis. AIMS: To attempt to corroborate the presence of acid GER in children with CMPA, as well as to find a characteristic profile through the 24-hour pH monitoring study in children with GER and CMPA METHODS: The intraesophageal pH monitoring studies performed on 47 children with CMPA were reviewed...
January 2014: Revista de Gastroenterología de México
Elen R Valitova, Berna Bayrakçı, Serhat Bor
BACKGROUND/AIMS: There is a general belief that gastroesophageal reflux attacks appear more frequently after quick meal, which is without powerful scientific basis, and the general advise to patients is to eat slowly. We aimed to determine whether the speed of eating has an impact on reflux attacks and symptoms in gastroesophageal reflux disease patients. MATERIALS AND METHODS: 24-h intraesophageal pH monitoring was performed to 60 patients with frequent gastroesophageal reflux disease symptoms (39 women) in a tertiary referral center...
2013: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
Shinya Izawa, Yasushi Funaki, Akihito Iida, Kentaro Tokudome, Yasuhiro Tamura, Naotaka Ogasawara, Makoto Sasaki, Kunio Kasugai
BACKGROUND: The symptom improvement rate is low with proton pump inhibitors (PPIs) in nonerosive reflux disease (NERD). The underlying pathogenic mechanism is complex. Esophageal motility disorders (EMDs) are thought to be a factor, but their prevalence, type, symptoms and the role played by gastroesophageal reflux (GER) in symptom onset have not been fully investigated. AIM: To investigate the role of GER in symptom onset in PPI-refractory NERD patients with EMDs...
2014: Digestion
R S Choung, G R Locke, D D Francis, D Katzka, P J Winkle, W C Orr, M D Crowell, K Devault, W S Harmsen, A R Zinsmeister, N J Talley
BACKGROUND: Low basal lower esophageal sphincter (LES) pressure and transient LES relaxations are major causes of gastroesophageal reflux disease (GERD). Pumosetrag, a novel selective partial 5HT3 receptor agonist, showed a promising effect on reducing reflux events in health. We aimed to evaluate the effect of pumosetrag on changes in reflux episodes, lower esophageal sphincter pressure (LESP), and specific symptoms in patients with GERD receiving a refluxogenic meal. METHODS: Patients with GERD, who developed heartburn and/or regurgitation after ingestion of a refluxogenic meal, were randomized to 1 of 3 dose levels of pumosetrag (0...
January 2014: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Rachel Rosen, Janine Amirault, Emily Giligan, Umakanth Khatwa, Samuel Nurko
BACKGROUND: One of the primary reasons for referral for reflux testing is to correlate reflux events with symptoms such as cough. Adult studies have suggested that symptom recording is flawed and pediatricians feel this is an even more significant problem because there may be errors in both parental and patient reports. We hypothesize that intraesophageal pressure recording (IEPR) provides an objective method to identify coughs during reflux testing in children. METHODS: We recruited 20 children undergoing multichannel intraluminal impedance with pH (pH-MII) testing for the evaluation of cough...
January 2014: Journal of Pediatric Gastroenterology and Nutrition
Joshua T Watson, Fouad J Moawad, Ganesh R Veerappan, John T Bassett, Corinne L Maydonovitch, John D Horwhat, Roy K H Wong
BACKGROUND: The mainstay of medical therapy for Barrett's esophagus is normalization of esophageal acid exposure with proton pump inhibitors (PPIs). However, the optimal dose and whether once daily or twice daily is required for acid suppression is unknown. AIM: The purpose of this study was to assess whether adequate intra-esophageal acid suppression could be achieved with once daily versus twice daily omeprazole in patients with gastroesophageal specialized intestinal metaplasia (GEJSIM), short-segment (SSBE) and long-segment Barrett's esophagus (LSBE)...
August 2013: Digestive Diseases and Sciences
Karuna Datta, Kshitij Rahalkar, Dinesh Kumar Dubey, B A Krishna Prasad
PURPOSE OF THE STUDY: Endoscopy Normal Reflux Disease (ENRD) is a common presentation of reflux disease. These patients are symptomatic but do not have abnormal endoscopy findings. They may have pathological intraesophageal reflux. Lifestyle modifications are the mainstay of management of these patients. Posture plays an important role in their management. It was felt that exact quantification of reflux pattern with different postures in ENRD cases should be studied to include it as a part of management of these cases...
October 2011: Indian Journal of Physiology and Pharmacology
Masahito Aimi, Kenji Furuta, Yoshiya Morito, Kousuke Fukazawa, Kyoichi Adachi, Yoshikazu Kinoshita
BACKGROUND/AIMS: Esophagogastric junctional lesions, such as mucosal breaks with Los Angeles grade A or B reflux esophagitis, lacerations in Mallory Weiss syndrome, and short segment Barrett's esophagus, are mainly found in the right anterior wall of the distal esophagus. Asymmetrical lower esophageal sphincter pressure and resting radial asymmetrical acid reflux may be causes of this asymmetrical distribution of reflux esophagitis and short segment Barrett's esophagus. We developed a novel pH and pressure catheter to investigate the asymmetrical distributions of pH and intra-esophageal pressure in the distal esophagus...
January 2013: Journal of Neurogastroenterology and Motility
Chaoxian Zhang, Like Guo, Xiaofeng Guo, Xiaohe Guo, Guangyan Li
OBJECTIVE: To study the clinical curative effect, safety and mechanism of action of electroacupuncture combined with Zhizhukuanzhong capsules (ZZKZC) in treating gastroesophageal reflux disease (GERD). METHODS: A total of 480 patients with confirmed GERD were randomly divided into four groups: the electroacupuncture group, the ZZKZC group, the combined therapy group, and the control group, with 120 cases in each group. Each case in the electroacupuncture group was treated with electroacupuncture on Zusanli (ST 36), Zhongwan (CV 12), Neiguan (PC 6),Taichong (LR 3) and Gongsun (SP 4) once daily for 6 weeks...
September 2012: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
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