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Marie-Cécile Valéra, Emmanuelle Noirrit-Esclassan, Marion Dupuis, Coralie Fontaine, Françoise Lenfant, Anne Briaux, Cendrine Cabou, Cedric Garcia, Olivier Lairez, Jean-Michel Foidart, Bernard Payrastre, Jean-François Arnal
Estetrol (E4) is a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, and the physiological role of this hormone is unknown. Interestingly, E4 was recently evaluated in preclinical and phase II-III clinical studies in combination with a progestin, with the advantage to not increase the circulating level of coagulation factors, at variance to oral estradiol or ethinylestradiol. Here, we evaluated the effect of E4 on hemostasis and thrombosis in mouse. Following chronic E4 treatment, mice exhibited a prolonged tail-bleeding time and were protected from arterial and also venous thrombosis in vivo...
June 18, 2018: Molecular and Cellular Endocrinology
I D Stulin, M V Tardov, N L Kunelskaya, A V Boldin, A A Filin, A V Didenko
The article describes a series of seven cases characterized by a change in the type of attack in the perimenopausal period: migraine attacks before menopause and cochleovestibular paroxysms after the onset of menopause. Clinical data and results of diagnostic tests are presented and the possible link of both attack variants with cervical pathology is discussed. The authors explain this dynamics by stem neural integrator dysfunction during hormonal changes.
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Xuefeng Qiao, Danfei Xu, Dandan Sun, Sijin Sun, Zhiping Huang, Wei Cui
BACKGROUND: Interleukin-18-137G/C, -607G/T polymorphisms play multiple roles in various cancers. However, studies focused on its involvement in breast cancer remain controversial, and no study has taken the interaction between interleukin-18 (IL-18) gene polymorphism and body mass index (BMI), menopause into consideration. The study investigated the association between IL-18-137, -607 polymorphisms and risk of breast cancer and a possible interaction between the 2 single nucleotide polymorphisms (SNPs) and BMI, menopause in Chinese Han woman...
June 21, 2018: Journal of Clinical Laboratory Analysis
Kirsti Vik Hjerkind, Merete Ellingjord-Dale, Anna L V Johansson, Hildegunn Siv Aase, Solveig Roth Hoff, Solveig Hofvind, Siri Fagerheim, Isabel Dos-Santos-Silva, Giske Ursin
BACKGROUND: Volumetric mammographic density (VMD) measures can be obtained automatically, but it is not clear how these relate to breast cancer risk factors. METHODS: The cohort consisted of 46 428 women (aged 49-71 years) who participated in BreastScreen Norway between 2007 and 2014 and had information on VMD and breast cancer risk factors. We estimated means of percent and absolute VMD associated with age, menopausal status, body mass index (BMI), and other factors...
June 20, 2018: Cancer Epidemiology, Biomarkers & Prevention
Kathleen M Sturgeon, Wayne Y Foo, Mariane L Heroux, Kathryn Schmitz
Breast cancer survivors who carry a genetic mutation for one of the BRCA genes often undergo surgically-induced menopause a decade or more before the usual age of natural menopause. These women are at elevated risk for multiple negative health outcomes, including metabolic diseases, heart disease, and cancer recurrence. Effects of a 12-month commercially available web-based lifestyle program (Precision Nutrition) were tested on body composition and markers of inflammation in a randomized controlled trial. Participants (N=35) were BRCA1/2+, breast cancer survivors, and had completed surgically-induced menopause at age <45 years...
June 20, 2018: Cancer Prevention Research
David Cheishvili, Surabhi Parashar, Niaz Mahmood, Ani Arakelian, Richard Kremer, David Goltzman, Moshe Szyf, Shafaat A Rabbani
Osteoporosis is one of the most common age-related progressive bone diseases in elderly people. Approximately one in three women and one in five men are predisposed to developing OP. In postmenopausal women a reduction in bone mineral density (BMD) leads to an increased risk of fractures. In the current study we delineated the DNA methylation signatures in whole blood samples of postmenopausal osteoporotic women. We obtained whole blood DNA from 22 normal women and 22 postmenopausal osteoporotic women (51-89 years) from the Canadian Multicenter Osteoporosis Study (CaMos) cohort...
June 20, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
Min Huang, Ya-Lin Cheng, Ji-Tao Zeng, Xiao-Ya Su, Hong Liu
Inhibin-α, a member of the transforming growth factor (TGF-β) superfamily, has been involved in bone turnover during the menopausal transition via endocrine effects, and it was previously reported that inhibins may antagonize the function of BMPs. Certainly, one of the most important functions of BMPs is to induce osteogenic differentiation. BMP9 as one of the most potent BMPs to induce osteogenic differentiation has gotten more and more attentions. Nonetheless, the effects of inhibin-α on osteogenesis remain unknown...
June 20, 2018: Journal of Cellular Biochemistry
Pamela S Hinton, Laura C Ortinau, Rebecca K Dirkes, Emily L Shaw, Matthew W Richard, Terese Z Zidon, Steven L Britton, Lauren G Koch, Victoria J Vieira-Potter
Background: Osteoporosis and related fractures, decreased physical activity, and metabolic dysfunction are serious health concerns for postmenopausal women. Soy protein might counter the negative effects of menopause on bone and metabolic health due to the additive or synergistic effects of its bioactive components. Objective: To evaluate the effects of ovariectomy (OVX) and a soy-protein diet (SOY) on bone outcomes in female, low-capacity running (LCR) rats selectively bred for low aerobic fitness as a model of menopause...
June 2018: Bone Reports
Zahra Yazdanpanahi, Marzieh Nikkholgh, Marzieh Akbarzadeh, Saeedh Pourahmad
BACKGROUND: Menopause is associated with decreased sexual activity and a feeling of decreased attractiveness and sexual potency. This study tested the hypothesis that sexual health in postmenopausal women is not the same as nonmenopausal women with regard to symptoms of stress, anxiety, and depression. MATERIALS AND METHODS: This cross-sectional study was conducted in 12 health centers in Shiraz between April and September 2015; 310 postmenopausal women included by convenient sampling...
May 2018: Journal of Family & Community Medicine
Valeria Aparecida Costa-Hong, Henrique Cotchi Simbo Muela, Thiago Andrade Macedo, Allan Robson Kluser Sales, Luiz Aparecido Bortolotto
BACKGROUND: Evidences suggest that central hemodynamics indexes are independent predictors of future cardiovascular events and all-cause mortality. Multiple factors have been pointed to have potential influence on central aortic function: height, heart rate, left ventricular ejection duration and blood pressure level. Data related to the influence of gender and postmenopausal status on aortic waveform reflection is scarce. We aim to evaluate the impact of gender and menopause on central blood pressure of hypertensive patients...
June 19, 2018: BMC Cardiovascular Disorders
M C Vlot, M den Heijer, R T de Jongh, M G Vervloet, W F Lems, R de Jonge, B Obermayer-Pietsch, A C Heijboer
Measurements of bone markers (BMs) in peripheral blood or urine are a pivotal part of bone research within modern clinical medicine. In recent years the use of BMs increased substantially as they can be useful either to diagnose bone (related) disease and to follow its natural history, but also to monitor the effects of interventions. However, the use of BMs is still complicated mainly due to (pre)analytical variability of these substances, limited accessibility of assays, variable cut-off values in different countries and laboratories and heterogeneous results with regard to clinical implications of measuring BMs in several studies...
June 16, 2018: Bone
N Brusselaers, R M Tamimi, P Konings, B Rosner, H-O Adami, J Lagergren
Background: There are considerable knowledge gaps concerning different estrogen and progestin formulations, regimens, and modes of administration of menopausal hormone therapy and the risk of breast cancer. Our objective was to assess the different treatment options for menopausal hormone therapy and the risk of breast cancer. Patients and methods: This Swedish prospective nationwide cohort study included all women who received ≥1 hormone therapy prescription during the study period 2005-2012 (290,186 ever-users), group-level matched (1:3) to 870,165 never-users; respectively 6,376 (2...
June 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
L Elaine Waetjen, Sybil L Crawford, Po-Yin Chang, Barbara D Reed, Rachel Hess, Nancy E Avis, Sioban D Harlow, Gail A Greendale, Sheila A Dugan, Ellen B Gold
OBJECTIVE: To evaluate factors associated with incident self-reported vaginal dryness and the consequences of this symptom across the menopausal transition in a multiracial/ethnic cohort of community-dwelling women. METHODS: We analyzed questionnaire and biomarker data from baseline and 13 approximately annual visits over 17 years (1996-2013) from 2,435 participants in the Study of Women's Health Across the Nation, a prospective cohort study. We used discrete-time Cox proportional-hazards regression to identify predictors of incident vaginal dryness and to evaluate vaginal dryness as a predictor of pain during intercourse and changes in sexual intercourse frequency...
June 18, 2018: Menopause: the Journal of the North American Menopause Society
T Filardi, V Carnevale, R Massoud, C Russo, L Nieddu, F Tavaglione, I Turinese, A Lenzi, E Romagnoli, S Morano
PURPOSE: Patients with type 2 diabetes (T2DM) have increased fracture risk. Osteopontin (OPN) is a protein involved in bone remodeling and inflammation. The aim of this study was to evaluate the association of OPN with fracture prevalence and with metabolic parameters in post-menopausal women with T2DM. METHODS: Sixty-four post-menopausal women with T2DM (age 67.0 ± 7.8 years, diabetes duration 8.9 ± 6.7 years), enrolled in a previous study, were followed up (3...
June 18, 2018: Journal of Endocrinological Investigation
Fernando V Ramirez Rozzi
To understand the diversity of human growth and development from an evolutionary point of view, there is an urgent need to characterize the life-history variables of vanishing forager societies. The small body size of the Baka pygmies is the outcome of a low growth rate during infancy. While the ages at sexual maturity, menarche, and first delivery are similar to those in other populations, fertility aspects are unknown. In the Le Bosquet district in Cameroon, thanks to systematic birth records kept from 1980 onwards, we were able to assign ages to individuals with certainty...
June 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
Flávia Ignácio Antônio, Robert D Herbert, Kari Bø, Ana Carolina Japur Sá Rosa-E-Silva, Lúcia Alves Silva Lara, Maira de Menezes Franco, Cristine Homsi Jorge Ferreira
QUESTION: Are there differences in the effectiveness of pelvic floor muscle training on pelvic floor muscle strength and urinary incontinence symptoms in postmenopausal women who are and are not using hormone therapy? DESIGN: Randomised, controlled trial with concealed allocation, blinded assessors, and intention-to-treat analysis. PARTICIPANTS: Ninety-nine postmenopausal women, 38 of whom were using daily systemic oestrogen/progestogen therapy...
June 15, 2018: Journal of Physiotherapy
Marco Gentile, Gabriella Iannuzzo, Amalia Mattiello, Gennaro Marotta, Fabiana Rubba, Arcangelo Iannuzzi, Salvatore Panico, Paolo Rubba
BACKGROUND: Lipoprotein (a) (Lp [a]) is associated with premature atherosclerosis in menopausal women without metabolic syndrome (MS). MS is the main confounder in the relationship between Lp(a) and atherosclerosis in menopausal women. We have evaluated the relationship between Lp(a) and small dense-low density lipoprotein (sd-LDL) in 228 menopausal women participating to Progetto Atena. METHODS: Lp(a) was measured and LDL particle separation was performed: mean LDL diameter and LDL score (% of sd-LDL) particles calculated...
June 19, 2018: Acta Cardiologica
Monique Cristine de Oliveira, Lilian Brites Campos-Shimada, Maria Raquel Marçal-Natali, Emy Luiza Ishii-Iwamoto, Clairce Luzia Salgueiro-Pagadigorria
OBJECTIVE:  The aim of this work was to evaluate the changes caused by estrogen deficiency in lipid metabolism. METHODS:  This study encompassed direct measurements of plasma biochemical analyses, liver lipid contents, and assessments of the mitochondrial β-oxidation capacity as well as an evaluation of the liver redox status in an animal model of estrogen deficiency. RESULTS:  When compared with control mice, the livers of ovariectomized (OVX) mice presented considerable accretions in their lipid contents, which were accompanied by increased levels of lipid peroxidation in liver homogenates and mitochondria from OVX groups and decreased reduced glutathione (GSH) contents...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
S Zafar Abbas, Vijayata Sangawan, Asim Das, Anil Kumar Pandey
Background: Menopause is associated with increased cardiovascular disease (CVD) risk. Arterial stiffness, a biomarker of vascular aging, increases the risk for CVD. Aims and Objectives: The study was aimed to determine whether menopause is associated with arterial stiffness amongst natural and surgical menopausal women. Materials and Methods: We conducted a cross-sectional study amongst natural postmenopausal women, with Surgical menopause and Premenopausal...
March 2018: Indian Journal of Endocrinology and Metabolism
Sabina Zacharieva, Ralitsa Robeva, Silvia Andonova, Radoslava Vazharova, Lubomir Balabanski, Maya Atanasoska, Draga Toncheva, Atanaska Elenkova, Alexey Savov
11β-Hydroxylase deficiency is the second most common enzyme disorder after 21-hydroxylase deficiency causing congenital adrenal hyperplasia (CAH11β ). In females, the clinical phenotype of CAH11β classic forms is associated with ambiguous genitalia, virilization and hypertension, while most common complaints in milder non-classic forms include hirsutism, acne, menstrual disturbances, and infertility. Herein, we present clinical and genetic characteristics of an adult woman with 11β-hydroxylase deficiency, hypertension and infertility; she has been followed up from her first pregnancy to her early menopause...
June 17, 2018: Gynecological Endocrinology
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