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I Jardin, G Canlorbe, J-L Mergui, M Nikpayam, J Belghiti, C Uzan, H Azaïs
Genitourinary syndrome of menopause (GSM) brings together a collection of signs including vaginal dryness, burning sensation and itching discomfort as well as deterioration of sexual health, dysuria, urgenturia and repeated urinary infections and may be responsible for a significant impairment of quality of life in symptomatic postmenopausal women. The management of GSM therefore represents a public health issue. Systemic or local hormonal treatments are frequently offered, as well as non-hormonal treatments...
September 18, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
Alexandra C Purdue-Smithe, Brian W Whitcomb, JoAnn E Manson, Susan E Hankinson, Bernard A Rosner, Lisa M Troy, Elizabeth R Bertone-Johnson
Early natural menopause, the cessation of ovarian function prior to age 45, affects ~10% of women and increases risk of cardiovascular disease and other conditions. Laboratory evidence suggests a potential role of dairy foods in the ovarian aging process; however, no prior epidemiologic studies have evaluated how dairy intake is associated with risk of early menopause. We therefore evaluated how intakes of total, low-fat, high-fat and individual dairy foods are associated with early menopause in the Nurses' Health Study II...
September 18, 2018: American Journal of Epidemiology
Ginger D Constantine, James A Simon, James H Pickar, David F Archer, Brian Bernick, Shelli Graham, Sebastian Mirkin
OBJECTIVE: To review safety, efficacy, and pharmacokinetic (PK) data from the phase 3 REJOICE trial, which evaluated a 17ß-estradiol (E2) softgel vaginal insert approved in 2018 for moderate to severe dyspareunia associated with menopausal vulvar and vaginal atrophy (VVA). METHODS: REJOICE ( NCT02253173) was a randomized, double-blind, placebo-controlled trial in which women with moderate to severe dyspareunia due to menopausal VVA received 4 µg, 10 µg, or 25 µg of an E2 vaginal insert or placebo for 12 weeks...
September 21, 2018: Current Medical Research and Opinion
Susanne Huber, Martin Fieder
There is an ongoing debate why a trait like human menopause should have evolved. Adaptive explanations explain menopause with fitness benefits of ceasing reproduction, whereas non-adaptive explanations view it as an epiphenomenon. Here we present data in support of non-adaptive explanations of menopause suggesting a maximum shelf-life of oocytes. By analyzing the association between lifespan and age at reproductive senescence across 49 mammal species, we find that the positive association levels off in long lived species, indicating that the age at reproductive senescence has an upper limit...
September 20, 2018: Scientific Reports
Chunzhe Duan, Evelyn Talbott, Maria Brooks, Sung Kyun Park, Rachel Broadwin, Karen Matthews, Emma Barinas-Mitchell
INTRODUCTION: Effects of more than one-year exposure to air pollution on atherosclerosis is seldom studied. This paper aims to examine the association between five-year exposure to particulate matter ≤2.5 μm (PM2.5 ), ozone (O3 ) and atherosclerosis observed about seven years later in late midlife women. MATERIAL AND METHODS: This study was conducted among 1188 women of the Study of Women's Health Across the Nation (SWAN) from five sites, Detroit, MI; Oakland, CA; Pittsburgh, PA; Chicago, IL; and Newark, NJ, with available data on both air pollutant exposure and carotid ultrasound scans...
September 17, 2018: International Journal of Hygiene and Environmental Health
Mauricio Sanchez-Barajas, Lorena Del Rocio Ibarra-Reynoso, Marco Antonio Ayala-Garcia, Juan Manuel Malacara
BACKGROUND: Women after menopause increase risk for cardiovascular disease and several factors may be related. The purpose was to study biological and psychosocial factors associated with early cardiovascular damage in pre- and postmenopausal women, assessed with carotid intima-media thickness vs flow-mediated dilatation. METHODS: Women 45 to 57 years old were grouped in the pre- (n = 60), early (n = 58) and late post-menopause (n = 59). Anthropometric, metabolic and hormonal data were registered, as well as measures of depression, anxiety, submission, perceived stress, and sleep alterations...
September 20, 2018: BMC Women's Health
Corinna Serviente, Amy S Burnside, Sarah Witkowski
Endothelial microparticles (EMPs) are related to cardiovascular disease (CVD) risk. Risk factors for CVD increase with menopause, while greater cardiorespiratory fitness is generally expected to reduce CVD risk. The effects of habitual physical activity on endothelial health may be due in part to the effect of acute exercise on circulating EMPs. PURPOSE: To evaluate the effect of an acute bout of exercise on CD62E+ and CD31+ /42b- EMPs in healthy fit midlife women at different menopausal stages...
September 20, 2018: Journal of Applied Physiology
Saba Jalali, Nitin Shivappa, James R Hébert, Zeinab Heidari, Azita Hekmatdoost, Bahram Rashidkhani
Chronic inflammation is implicated in breast cancer (BrCa) development; however, studies on the association of the inflammatory potential of diet and breast cancer have produced conflicting results. With this as background, we investigated the association between dietary inflammatory index (DII® ) scores and BrCa risk in an Iranian case-control study. In this study, 136 newly diagnosed breast cancer patients and 272 hospitalized controls were recruited using convenience sampling. DII scores were computed from dietary intake data collected through a validated food frequency questionnaire (FFQ)...
September 20, 2018: Nutrition and Cancer
Emilie Gadéa, Emilie Thivat, Pascale Dubray-Longeras, Marie Arbre, Isabelle Van-Praagh, Marie-Ange Mouret-Reynier, Pauline Herviou, Joyce Dohou, Angeline Ginzac, Martine Duclos, Béatrice Morio, Xavier Durando
In breast cancer patients, weight and fat mass changes observed after chemotherapy have been related to poor prognosis but some recent works using modern chemotherapy failed to find this correlation with weight gain. In this study, the extent of changes in weight and body composition (DEXA, impedance) was characterized until six months after current chemotherapy, in 50 post-menopausal women with breast cancer. The evolution of factors contributing to the energy balance and some biological factors were also described...
September 20, 2018: Nutrition and Cancer
Murilo Renato Matos Machado, Benedito de Sousa Almeida-Filho, Heloisa De Luca Vespoli, Eneida Boteon Schmitt, Jorge Nahas-Neto, Eliana A P Nahas
OBJECTIVE: The aim of the study was to evaluate the rate of and risk factors for low pretreatment vitamin D (VitD) levels in postmenopausal breast cancer (BC) women, compared with postmenopausal women without BC. METHODS: A cross-sectional clinical study was conducted to compare 209 women with BC (case group) to 418 women without BC (control group), age range: 45 to 75 years. The case group consisted of women diagnosed with BC, amenorrhea ≥12 months, aged ≥45 years, without use of medication or clinical conditions that might interfere with VitD levels...
September 17, 2018: Menopause: the Journal of the North American Menopause Society
Soheila Gholizadeh, Shahideh Jahanian Sadatmahalleh, Saeideh Ziaei
Background: Levels of estradiol decreases as women arrive the menopausal transition and enter to a low, steady level during the early postmenopause. In addition, memory dysfunction are highly prevalent during this period. Objective: Our study was designed to determine whether endogenous levels of estradiol are related to cognitive function in postmenopausal. Materials and Methods: The cross-sectional study was conducted between November 2015 to February 2016 on 209 healthy postmenopausal women...
July 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
Simone Alves de Almeida, Erick R G Claudio, Vinicius Mengal, Girlandia A Brasil, Eduardo Merlo, Priscila L Podratz, Jones B Graceli, Sonia A Gouvea, Gláucia Rodrigues de Abreu
There is an increase in the incidence of cardiovascular events such as myocardial infarction (MI) after menopause. However, the use of estrogen therapy (E2) remains controversial. The aim of this study was to evaluate the effects of E2, alone and combined with exercise training (ET), on cardiac function and remodeling in ovariectomized (OVX) rats after MI. Wistar female rats underwent ovariectomy, followed by MI induction were separated into five groups: S; MI; MI+ET; MI+E2; and MI+ET+E2. Fifteen days after MI or sham surgery, treadmill ET and/or estrogen therapy [17-β estradiol-3-benzoate (E2), s...
2018: Frontiers in Physiology
Ana P S Dornellas, Valter T Boldarine, Amanda P Pedroso, Lorenza O T Carvalho, Iracema S de Andrade, Tânia M Vulcani-Freitas, Carla C C Dos Santos, Cláudia M da Penha Oller do Nascimento, Lila M Oyama, Eliane B Ribeiro
Menopause-induced changes may include increased incidence of both depression/anxiety and obesity. We hypothesized that behavioral changes that may develop after ovarian failure could be related to neurochemical and metabolic aspects affected by this condition and that high-fat intake may influence these associations. The present study investigated in rats the effects of ovariectomy, either alone or combined with high-fat diets enriched with either lard or fish-oil, on metabolic, behavioral and monoaminergic statuses, and on gene expression of neuropeptides and receptors involved in energy balance and mood regulation...
2018: Frontiers in Neuroscience
Liyuan Li, Zhao Wang
Osteoporosis is the most common bone metabolic disease with a very high morbidity, and women usually got a higher risk of osteoporosis than men. The high incidence rate of osteoporosis in women was mainly caused by (1) women having fewer skeletons and bone mass, (2) pregnancy consuming a large amount of calcium and other nutrients, and most importantly (3) the cease of estrogen secretion by ovaries after menopause. Along with ovarian aging, the follicle pool gradually declines and the oocyte quality reduced, accompanied with decline in serum estrogen...
2018: Advances in Experimental Medicine and Biology
Gulzhan Gabdulina, Melody Kasher, Aliya Beissebayeva, Dana Mussabaeva, Alexander Tokarev, Gulmira Mominova, Gulnar Essirkepova, Ainash Amanzholova, Korlan Zaurbekova, Maira Saparbaeva, Maira Bizhanova, Moldir Kulshymanova, Gregory Livshits
PURPOSE: We aimed to assess which of the major risk factors associated with rheumatoid arthritis (RA) severity are also associated with osteoporosis-related phenotypes (OP-RP) in the native population of Kazakhstan. METHODS: Four hundred six RA patients (90.6% females) with 397 controls-unaffected first-degree relatives were recruited. Biochemical factors were recorded, and OP-RP were assessed using QCT scans and ultrasound densitometry (US) of the forearm to estimate cortical indices (CI), spongial bone mineral density (BMDSPN ), and US_T-scores...
September 19, 2018: Archives of Osteoporosis
Andrea G Kattah, Carin Y Smith, Liliana Gazzuola Rocca, Brandon R Grossardt, Vesna D Garovic, Walter A Rocca
BACKGROUND AND OBJECTIVES: Premenopausal women who undergo bilateral oophorectomy are at a higher risk of morbidity and mortality. Given the potential benefits of estrogen on kidney function, we hypothesized that women who undergo bilateral oophorectomy are at higher risk of CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We performed a population-based cohort study of 1653 women residing in Olmsted County, Minnesota who underwent bilateral oophorectomy before age 50 years old and before the onset of menopause from 1988 to 2007...
September 19, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Christiana Campani Nygaard, Lucas Schreiner, Thiago Picolli Morsch, Rodrigo Petersen Saadi, Marina Faria Figueiredo, Alexandre Vontobel Padoin
OBJECTIVE:  To analyze the prevalence of urinary incontinence (UI) in female patients with an indication for bariatric surgery, to investigate the potential risk factors and the impact on quality of life. METHODS:  A cross-sectional study with female patients with obesity. The evaluation consisted of a structured interview, a specific study form and quality of life questionnaires. The Poisson regression was performed to identify independent risk factors related to UI...
September 2018: Revista Brasileira de Ginecologia e Obstetrícia
Daniela Gama de Melo, Pedro Sérgio Soares Jallad, Luiz Gustavo Oliveira Brito
OBJECTIVE:  There are no published studies analyzing the quality of the information for lay women on the Internet regarding uterine fibroids. The accuracy of the provided material is also unknown. Thus, we have performed a cross-sectional study with 381 websites in the English and Brazilian Portuguese languages between May and December 2017. METHODS:  Two investigators performed the analysis, and the Cohen kappa coefficient was calculated to analyze the agreement between them...
September 2018: Revista Brasileira de Ginecologia e Obstetrícia
Uzma Chishti, Samar Elorbany, Munazza Akhtar, Jonathan Williams, Susan Heenan, Desmond P J Barton
No abstract text is available yet for this article.
September 19, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Magdalena Emilia Grzybowska, Dariusz Wydra
AIMS: To compare quality of life (QoL) in women with urinary incontinence (UI) using continence pads during the day versus all day and night; to identify risk factors for a 24-hour pad use; to calculate quality-adjusted life years (QALY). METHODS: A cross-sectional study in 331 women with lower urinary tract symptoms referred to urogynaecologic examination was conducted. Main outcome measures were the scores of King's Health Questionnaire (KHQ), clinical data, and KHQ-derived utility values...
September 19, 2018: International Journal of Clinical Practice
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