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https://www.readbyqxmd.com/read/29031089/17%C3%AE-estradiol-regulates-the-rna-binding-protein-nova1-which-then-regulates-the-alternative-splicing-of-estrogen-receptor-%C3%AE-in-the-aging-female-rat-brain
#1
Cody L Shults, Caitlin B Dingwall, Chun K Kim, Elena Pinceti, Yathindar S Rao, Toni R Pak
Alternative RNA splicing results in the translation of diverse protein products arising from a common nucleotide sequence. These alternative protein products are often functional and can have widely divergent actions from the canonical protein. Studies in humans and other vertebrate animals have demonstrated that alternative splicing events increase with advanced age, sometimes resulting in pathological consequences. Menopause represents a critical transition for women, where the beneficial effects of estrogens are no longer evident; therefore, factors underlying increased pathological conditions in women are confounded by the dual factors of aging and declining estrogens...
September 14, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29029258/acupuncture-improves-peri-menopausal-insomnia-a-randomized-controlled-trial
#2
Fu Cong, Zhao Na, Liu Zhen, Yuan Lu-Hua, Xie Chen, Yang Wen-Jia, Yu Xin-Tong, Yu Huan, Chen Yun-Fei
Study Objective: To evaluate the short-term efficacy of acupuncture for the treatment of peri-menopausal insomnia (PMI). Methods: Design: A randomized, participant-blind, placebo-controlled trial consisted of the acupuncture group (n=38) and placebo-acupuncture group (n=38). Setting: A tertiary teaching and general hospital. Participants: 76 peri-menopausal women with insomnia disorder based on the International Classification of Sleep Disorders, third Edition. Interventions: A 10-session of acupuncture at bilateral Shenshu (BL 23) and Ganshu (BL 18) with unilateral Qimen (LR 14) and Jingmen (GB 25) or Streitberger needles at the same acupoints was performed for over 3 weeks...
September 22, 2017: Sleep
https://www.readbyqxmd.com/read/29029113/estrogen-metabolism-in-abdominal-subcutaneous-and-visceral-adipose-tissue-in-postmenopausal-women
#3
Natalia Hetemäki, Hanna Savolainen-Peltonen, Matti J Tikkanen, Feng Wang, Hanna Paatela, Esa Hämäläinen, Ursula Turpeinen, Mikko Haanpää, Veera Vihma, Tomi S Mikkola
CONTEXT: In postmenopausal women, adipose tissue (AT) levels of estrogens exceed circulating concentrations. While increased visceral AT after menopause is related to metabolic diseases, little is known about differences in estrogen metabolism between different AT depots. OBJECTIVE: We compared concentrations of and metabolic pathways producing estrone and estradiol in abdominal subcutaneous and visceral AT in postmenopausal women. DESIGN, SETTING, PATIENTS, AND INTERVENTIONS: AT and serum samples were obtained from 37 postmenopausal women undergoing surgery for non-malignant gynecological reasons...
September 29, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29027807/annals-express-biochemistry-of-the-menopause
#4
John W Honour
The life of a human female is characterised from teenage years by monthly menstruation which ceases (the menopause) typically between the age of 40 and 60 years. The potential for reproduction declines and ceases as the ovaries become depleted of follicles. A transition period in mid-life, for 2 to 10 years, when menstruation is less regular is called the peri-menopause. The menopause is associated with a significant decline in plasma concentrations of sex hormones, an increase in the concentrations of the gonadotrophins and changes in other hormones such as the inhibins...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29027349/aerobic-exercise-training-lowers-platelet-reactivity-and-improves-platelet-sensitivity-to-prostacyclin-in-pre-and-postmenopausal-women
#5
M H Lundberg Slingsby, M Nyberg, J Egelund, C M Mandrup, R Frikke-Schmidt, N S Kirkby, Y Hellsten
BACKGROUND: The risk of atherothrombotic events increases after menopause. Regular physical activity has been shown to reduce platelet reactivity in younger women, but it is unknown how regular exercise affects platelet function after menopause. OBJECTIVES: To examine the effects of regular aerobic exercise in late pre- and recent postmenopausal women by testing basal platelet reactivity and platelet sensitivity to prostacyclin and nitric oxide. METHODS: 25 sedentary, but healthy, late premenopausal and 24 matched recently postmenopausal women, mean (95% confidence interval) 49...
October 12, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29025323/cardiovascular-autonomic-responses-in-the-vcd-rat-model-of-menopause-effects-of-short-and-long-term-ovarian-failure
#6
Domitila A Huber, Darlan Bazilio, Flaviano Lorenzon, Sibele Sehnem, Lucas Pacheco, Janete A Anselmo-Franci, Fernanda B Lima
After menopause, hypertension elevates the risk of cardiac diseases, one of the major causes of women's morbidity. The gradual depletion of ovarian follicles in rats, induced by 4-vinylcyclohexene diepoxide (VCD), is a model for studying the physiology of menopause. 4-Vinylcyclohexene diepoxide treatment leads to early ovarian failure (OF) and a hormonal profile comparable to menopause in humans. We have hypothesized that OF can compromise the balance between sympathetic and parasympathetic tones of the cardiovascular system, shifting toward dominance of the former...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29024988/low-dose-metronomic-delivery-of-cyclophosphamide-is-less-detrimental-to-granulosa-cell-viability-and-ovarian-function-than-maximum-tolerated-dose-delivery-in-the-mouse
#7
Jacqueline Dynes, Kata Osz, Allyssa Hooper, Jim Petrik
Chemotherapy can cause early menopause or infertility in women and have a profound negative impact on the quality of life of young female cancer survivors. Various factors are known to influence the risk of chemotherapy-induced ovarian failure, including the drug dose and treatment duration; however, the scheduling of dose administration has not yet been evaluated as an independent risk factor. We hypothesized that Low-Dose Metronomic (LDM) chemotherapy scheduling would be less detrimental to ovarian function than the traditional Maximum-Tolerated Dose (MTD) strategy...
August 30, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024986/stromal-fibroblasts-from-perimenopausal-endometrium-exhibit-a-different-transcriptome-than-those-from-the-premenopausal-endometrium
#8
David W Erikson, Fatima Barragan, Terhi T Piltonen, Joseph C Chen, Shaina Balayan, Juan C Irwin, Linda C Giudice
Human endometrium undergoes extensive regeneration on a cyclic basis in premenopausal women and likely occurs through the contribution of stem/progenitor cells. Menopause results in the permanent cessation of menstrual cycles and is preceded by perimenopause, a period of several years in which endocrine and biological changes occur and is a period of risk for endometrial proliferative disorders. The objectives of this study were to identify mesenchymal stem cells (eMSC) and stromal fibroblasts (eSF) in endometrium of perimenopausal women and perform expression profile analysis of perimenopausal eMSC and eSF to gain insight into the biology of stem/progenitor and lineage cell populations during the transition to menopause...
August 19, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024954/physical-activity-a-primary-health-quality-determinant-among-community-dwelling-geriatric-women-in-taiwan
#9
Ching Hwa Hsu, Heng-Hsin Tung, Daniel L Clinciu, Liang-Kung Chen, Wei-Hsian Yin, Usman Iqbal, Tsae-Jyy Wang
Objective: To investigate the associations between frailty, physical activity and depression in community-dwelling geriatric women. Design: A cross-sectional research design. Setting: Community geriatric women in Illan County, Taiwan. Study participants: Of note 216 participants, 65 years and older with full mobility, independent and able to communicate in Mandarin or Taiwanese Hokkien. Main Outcome Measures: An average weekly physical activity score International Physical Activity Questionnaire-Short Form (IPAQ-SF) and Taiwan Geriatric Depression Scale...
August 19, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29024840/a-case-report-of-endometriosis-presenting-as-an-acute-small-bowel-obstruction
#10
Daniel L Chan, Dorothy Chua, Praveen Ravindran, Marisol Perez Cerdeira, Isabella Mor
INTRODUCTION: Endometriosis is a common and benign condition that causes significant morbidity to women of childbearing age. It uncommonly affects the gastrointestinal tract and rarely manifests as an acute small bowel obstruction. PRESENTATION OF CASE: A 46-year old female presented to the emergency department with signs and symptoms consistent with an acute small bowel obstruction. She had a paucity of background surgical history, having only had a laparoscopic cholecystectomy...
October 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29024114/iron-deficiency-among-blood-donors-experience-from-the-danish-blood-donor-study-and-from-the-copenhagen-ferritin-monitoring-scheme
#11
REVIEW
A S Rigas, O B Pedersen, K Magnussen, C Erikstrup, H Ullum
Blood components collected from blood donors are an invaluable part of modern-day medicine. A healthy blood donor population is therefore of paramount importance. The results from the Danish Blood Donor Study (DBDS) indicate that gender, number of previous donations, time since last donation and menopausal status are the strongest predictors of iron deficiency. Only little information on the health effects of iron deficiency in blood donors exits. Possibly, after a standard full blood donation, a temporarily reduced physical performance for women is observed...
October 10, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/29021911/interval-exercise-increases-angiogenic-cell-function-in-postmenopausal-women
#12
Emma Harris, Mark Rakobowchuk, Karen M Birch
INTRODUCTION: Exercise can help to negate the increased cardiovascular disease risk observed in women after the menopausal transition. This study sought to determine whether interval or continuous exercise has differential effects on endothelial function and circulating angiogenic cell (CAC) number and function in postmenopausal women. METHODS: Fifteen healthy postmenopausal women completed a 30 min acute moderate-intensity continuous (CON) and interval exercise (MOD-INT) session on a cycle ergometer on separate days...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29020676/acupuncture-may-improve-quality-of-life-in-menopausal-women-a-meta-analysis-of-randomized-controlled-trials
#13
Weihan Li, Yunyun Luo, Wenbin Fu, Rui Lei
No abstract text is available yet for this article.
October 12, 2017: Complementary Medicine Research
https://www.readbyqxmd.com/read/29020262/cigarette-smoking-and-risk-of-early-natural-menopause
#14
Brian W Whitcomb, Alexandra C Purdue-Smithe, Kathleen L Szegda, Maegan E Boutot, Susan E Hankinson, JoAnn E Manson, Bernard Rosner, Walter C Willett, A Heather Eliassen, Elizabeth R Bertone-Johnson
Menopause before age 45 affects roughly 5%-10% of women and is associated with higher risk of adverse health conditions. Smoking may increase early menopause risk; however, evidence is inconsistent, and data regarding smoking amount, duration, cessation and patterns over time and risk are scant. We used data from the Nurses' Health Study II of 116,429 nurses from 1989 through 2011 and Cox proportional hazards models to estimate hazard ratios (HR) adjusting for confounders. Compared to never-smokers, current smokers had a HR of 1...
August 10, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29020239/reproductive-aging-and-hepatic-fibrosis-progression-in-hiv-hepatitis-c-virus-co-infected-women
#15
Monika Sarkar, Jennifer L Dodge, Ruth M Greenblatt, Mark H Kuniholm, Jack DeHovitz, Michael Plankey, Andrea Kovacs, Audrey L French, Eric C Seaberg, Igho Ofotokun, Margaret Fischl, Edgar Overton, Erin Kelly, Peter Bacchetti, Marion G Peters
Background: Severity of hepatic fibrosis is greater in post- as compared to pre-menopausal women, perhaps due to protective effects of estrogens. However, prior studies of estrogen and liver fibrosis lack serial fibrosis measures, adjustment for age, or longitudinal observations in co-infected populations. Methods: In a longitudinal cohort of HIV/HCV co-infected women we assessed fibrosis progression across reproductive age using validated serum fibrosis markers, APRI and FIB-4...
July 26, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29019331/clinical-and-pathological-characteristics-of-triple-positive-breast-cancer-among-iraqi-patients
#16
Nada A S Alwan, Faisal H Mualla, Munawar Al Naqash, Saad Kathum, Furat N Tawfiq, Sana Nadhir
BACKGROUND: Breast cancer is the most common malignancy affecting the Iraqi population and the leading cause of cancer related mortality among Iraqi women. It has been well documented that prognosis of patients depends largely upon the hormone receptor contents and HER-2 over expression of their neoplasm. Recent studies suggest that Triple Positive (TP) tumors, bearing the three markers, tend to exhibit a relatively favorable clinical behavior in which overtreatment is not recommended...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29016679/perimenopause-and-emergence-of-an-alzheimer-s-bioenergetic-phenotype-in-brain-and-periphery
#17
Lisa Mosconi, Valentina Berti, Crystal Guyara-Quinn, Pauline McHugh, Gabriella Petrongolo, Ricardo S Osorio, Christopher Connaughty, Alberto Pupi, Shankar Vallabhajosula, Richard S Isaacson, Mony J de Leon, Russell H Swerdlow, Roberta Diaz Brinton
After advanced age, female sex is the major risk factor for Alzheimer's disease (AD). The biological mechanisms underlying the increased AD risk in women remain largely undetermined. Preclinical studies identified the perimenopause to menopause transition, a neuroendocrine transition state unique to the female, as a sex-specific risk factor for AD. In animals, estrogenic regulation of cerebral glucose metabolism (CMRglc) falters during perimenopause. This is evident in glucose hypometabolism and decline in mitochondrial efficiency which is sustained thereafter...
2017: PloS One
https://www.readbyqxmd.com/read/29016533/age-at-natural-menopause-and-hypertension-among-middle-aged-and-older-chinese-women
#18
Lulu Song, Lijun Shen, Hui Li, Bingqing Liu, Xiaoxuan Zheng, Lina Zhang, Yuan Liang, Jing Yuan, Youjie Wang
OBJECTIVES: Earlier age at natural menopause has been associated with cardiovascular disease in several studies, but evidence of its association with hypertension is lacking. We aimed to examine the relationship between age at natural menopause and hypertension among middle-aged and older Chinese women. METHODS: A total of 13 406 postmenopausal women (mean age 63.5 years) were enrolled from the Dongfeng-Tongji cohort study in Hubei province, China. Age at natural menopause was self-reported and was categorized into three groups (≤45, 46-52, or ≥53 years)...
October 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29016506/contraception-and-conception-after-bariatric-surgery
#19
Marie N Menke, Wendy C King, Gretchen E White, Gabriella G Gosman, Anita P Courcoulas, Gregory F Dakin, David R Flum, Molly J Orcutt, Alfons Pomp, Walter J Pories, Jonathan Q Purnell, Kristine J Steffen, Bruce M Wolfe, Susan Z Yanovski
OBJECTIVE: To examine contraceptive practices and conception rates after bariatric surgery. METHODS: The Longitudinal Assessment of Bariatric Surgery-2 is a multicenter, prospective cohort study of adults undergoing first-time bariatric surgery as part of routine clinical care at 10 U.S. hospitals. Recruitment occurred between 2005 and 2009. Participants completed preoperative and annual postsurgical assessments for up to 7 years until January 2015. This report was restricted to women 18-44 years old with no history of menopause, hysterectomy, or estrogen and progesterone therapy...
October 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28994639/migraine-menopause-and-hormone-replacement-therapy
#20
E Anne MacGregor
Perimenopause marks a period of increased migraine prevalence in women and many women also report troublesome vasomotor symptoms. Migraine is affected by fluctuating estrogen levels with evidence to support estrogen 'withdrawal' as a trigger of menstrual attacks of migraine without aura, while high estrogen levels can trigger migraine aura. Maintaining a stable estrogen environment with estrogen replacement can benefit estrogen-withdrawal migraine particularly in women who would also benefit from relief of vasomotor symptoms...
January 1, 2017: Post Reproductive Health
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