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https://www.readbyqxmd.com/read/29224248/is-there-a-pathogenetic-link-between-frontal-fibrosing-alopecia-androgenetic-alopecia-and-fibrosing-alopecia-in-a-pattern-distribution
#1
A Katoulis, K Diamanti, D Sgouros, A I Liakou, E Bozi, G Avgerinou, I Panayiotides, D Rigopoulos
Frequent coexistence of frontal fibrosing alopecia (FFA) and androgenetic alopecia (AGA) has been reported in the literature, but little attention has been given to the pathogenetic mechanisms underlying this potential association. FFA is characterized by progressive cicatricial fronto-temporal hairline recession, mostly affecting peri-menopausal women. Immune mechanisms seem to play a pivotal pathogenetic role. This article is protected by copyright. All rights reserved.
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29224101/estradiol-regulation-of-brown-adipose-tissue-thermogenesis
#2
Ismael González-García, Manuel Tena-Sempere, Miguel López
Physiologically, estrogens carry out a myriad of functions, the most essential being the regulation of the reproductive axis. Currently, it is also dogmatic that estrogens play an important role modulating energy balance and metabolism. In this sense, it is well known that low estrogens levels, occurring due to ovarian insufficiency, in conditions such as menopause or ovariectomy (OVX), are associated with increased food intake and decreased energy expenditure, leading to weight gain and obesity at long term...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224099/the-role-of-skeletal-muscle-estrogen-receptors-in-metabolic-homeostasis-and-insulin-sensitivity
#3
Andrea L Hevener, Zhenqi Zhou, Brian G Drew, Vicent Ribas
Women in the modern era are challenged with facing menopausal symptoms as well as heightened disease risk associated with increasing adiposity and metabolic dysfunction for up to three decades of life. Treatment strategies to combat metabolic dysfunction and associated pathologies have been hampered by our lack of understanding regarding the biological causes of these clinical conditions and our incomplete understanding regarding the effects of estrogens and the tissue-specific functions and molecular actions of its receptors...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224098/role-of-estrogens-in-the-regulation-of-liver-lipid-metabolism
#4
Brian T Palmisano, Lin Zhu, John M Stafford
Before menopause, women are protected from atherosclerotic heart disease associated with obesity relative to men. Sex hormones have been proposed as a mechanism that differentiates this risk. In this review, we discuss the literature around how the endogenous sex hormones and hormone treatment approaches after menopause regulate fatty acid, triglyceride, and cholesterol metabolism to influence cardiovascular risk.The important regulatory functions of estrogen signaling pathways with regard to lipid metabolism have been in part obscured by clinical trials with hormone treatment of women after menopause, due to different formulations, routes of delivery, and pairings with progestins...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29224097/menopause-estrogens-and-glucose-homeostasis-in-women
#5
Franck Mauvais-Jarvis
Randomized trials suggest that menopausal hormone therapy (MHT) prevents type 2 diabetes. Still, the mechanisms of these antidiabetic effects are a matter of controversy. This chapter provides an analysis of epidemiological and clinical evidence and proposes a mechanism for the effect of menopause and MHT on type 2 diabetes development and prevention. It discusses the beneficial role of estradiol on glucose homeostasis that is lost at menopause and improved by MHT, which delays type 2 diabetes. This chapter aims to reconcile differences among studies of the effect of menopause and MHT formulations on type 2 diabetes and argues that discrepancies arise from physiological differences in methods used to assess glucose homeostasis...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29223719/physical-activity-and-weight-loss-reduce-the-risk-of-breast-cancer-a-meta-analysis-of-139-prospective-and-retrospective-studies
#6
Prue J Hardefeldt, Ross Penninkilampi, Senarath Edirimanne, Guy D Eslick
BACKGROUND: Physical activity and weight loss have been shown to reduce breast cancer incidence in numerous observational studies. The aim of this meta-analysis was to assess the effect of both physical activity and weight loss on breast cancer incidence. Specifically, we aimed to complete subgroup analyses by the intensity of physical activity and menopausal status at breast cancer diagnosis to further elucidate the relationship between physical activity, weight loss, and breast cancer incidence...
October 17, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29222346/adiposity-inflammation-and-breast-cancer-pathogenesis-in-asian-women
#7
Neil M Iyengar, I-Chun Chen, Xi K Zhou, Dilip D Giri, Domenick J Falcone, Lisle A Winston, Hanhan Wang, Samantha Williams, Yen-Shen Lu, Tsu-Hsin Hsueh, Ann-Lii Cheng, Clifford A Hudis, Ching-Hung Lin, Andrew J Dannenberg
Obesity is associated with white adipose tissue (WAT) inflammation in the breast, elevated levels of the estrogen biosynthetic enzyme, aromatase, and systemic changes that predispose to breast cancer development. We examined whether WAT inflammation and its associated systemic effects correlate with body fat levels in an Asian population where body mass index (BMI) is not an accurate assessment of obesity and cancer risk. We also investigated whether biologic differences could account for the greater proportion of premenopausal estrogen receptor (ER)-positive breast cancer in Asian versus western countries...
December 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/29222337/menopausal-hormone-therapy-and-cardiovascular-disease-unraveling-the-role-of-age-and-time-since-menopause-onset
#8
Shilpa N Bhupathiraju, Meir J Stampfer
No abstract text is available yet for this article.
December 8, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/29222207/perineal-aggressive-angiomyxoma-in-a-menopausal-woman
#9
Corentin Deckers, Livia Dumitru, Fabrice Corbisier
Aggressive angiomyxoma (AA) is an uncommon mesenchymal tumour that is principally located in the soft tissues of the pelvis and perineum of young women. The primary features of this benign tumour are a local invasion, a high local recurrence rate and non-specific local clinical signs. We describe the case of a 58-year-old woman, initially treated for a Bartholin's cyst. Histological examination indicated the presence of an AA. The MRI showed a 7 cm soft tissue mass extending from the lateral wall of the vagina, into the left buttock and down into the subcutaneous tissue...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29221848/menopausal-related-symptoms-in-women-one-year-after-breast-cancer-surgery
#10
Melissa Mazor, Kathryn Lee, Anand Dhruva, Janine K Cataldo, Steven M Paul, Michelle Melisko, Betty J Smoot, Jon D Levine, Charles Elboim, Yvette P Conley, Christine Miaskowksi
CONTEXT: Approximately 60% to 100% of women with breast cancer experience at least one menopausal-related symptom. Little is known about associations between menopausal status and symptoms in women 12 months after breast cancer surgery. OBJECTIVE: Purpose of this study was to evaluate for differences in occurrence, severity, and distress of symptoms between pre- and post-menopausal women 12 months after breast cancer surgery. METHODS: Women with breast cancer (n=327) completed the Menopausal Symptoms Scale, that evaluated the occurrence, severity, and distress of 46 common menopausal-related symptoms...
December 5, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29221473/prevalence-of-somatic-and-urogenital-symptoms-as-well-as-psychological-health-in-women-aged-45-to-55-attending-primary-health-care-a-cross-sectional-study
#11
Lena Rindner, Gunilla Strömme, Lena Nordeman, Margareta Wigren, Dominique Hange, Ronny Gunnarsson, Gun Rembeck
BACKGROUND: Women's physical and mental ill-health such as stress-related symptoms, depression, pain, hypertension and urogenital health shows a marked increase around the ages 45-55 years. These women are an important group for Primary Health Care (PHC) due to their prevalent symptoms and illnesses. The aim of this study was to estimate the prevalence of somatic, psychological and urogenital symptoms in women aged 45-55 attending PHC and evaluate factors associated with severe symptoms...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29221432/sex-and-ethnic-racial-specific-risk-factors-for-gallbladder-disease
#12
Jane C Figueiredo, Christopher Haiman, Jacqueline Porcel, James Buxbaum, Daniel Stram, Neal Tambe, Wendy Cozen, Lynne Wilkens, Loic Le Marchand, Veronica Wendy Setiawan
BACKGROUND: Gallbladder disease (GBD) is a highly prevalent condition; however, little is known about potential differences in risk factors by sex and ethnicity/race. Our aim was to evaluate dietary, reproductive and obesity-related factors and GBD in multiethnic populations. METHODS: We performed a prospective analysis from the Multiethnic Cohort study who self-identified as non-Hispanic White (n = 32,103), African American (n = 30,209), Japanese (n = 35,987), Native Hawaiian (n = 6942) and Latino (n = 39,168)...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29220533/androgens-irregular-menses-and-risk-of-diabetes-and-coronary-artery-calcification-in-the-diabetes-prevention-program
#13
Catherine Kim, Vanita R Aroda, Ronald B Goldberg, Naji Younes, Sharon L Edelstein, MaryLou Carrion-Petersen, David A Ehrmann
Context: It is unclear whether relative elevations in androgens or irregular menses (IM) are associated with greater cardiometabolic risk among women who are already overweight and glucose intolerant. Research Design and Methods: We conducted a secondary analysis of Diabetes Prevention Program (DPP) and the DPP Outcomes Study (DPPOS). Participants included women with sex hormone measurements who did not use exogenous estrogen (n=1422). We examined whether free androgen index (FAI) or IM were associated with diabetes risk during the DPP/DPPOS or with coronary artery calcification (CAC) at DPPOS year 10...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29218771/menopause-related-appendicular-bone-loss-is-mainly-cortical-and-results-in-increased-cortical-porosity
#14
Åshild Bjørnerem, Xiaofang Wang, Minh Bui, Ali Ghasem-Zadeh, John L Hopper, Roger Zebaze, Ego Seeman
After menopause, remodeling becomes unbalanced and rapid. Each of the many remodeling transactions deposits less bone than it resorbed, producing microstructural deterioration. Trabecular bone is said to be lost more rapidly than cortical bone. However, because 80% of the skeleton is cortical, we hypothesized that most menopause-related bone loss and changes in bone microstructure are cortical, not trabecular in origin, and are the result of intracortical remodeling. Distal tibial and distal radial microstructure were quantified during 3...
December 8, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29218698/risk-factors-of-overactive-bladder-syndrome-and-its-relation-to-sexual-function-in-menopausal-women
#15
Sevil Hakimi, Elham Aminian, Sakineh Mohammad- Alizadeh Charandabi, Parvin Bastani, Marzieh Mohammadi
BACKGROUND: Overactive bladder syndrome is a common and annoying complication worldwide that could negatively affect the quality of life of afflicted individuals. We aimed to determine the prevalence and risk factors of overactive bladder syndrome and its relation to sexual function in healthy menopausal women. METHODS: This cross-sectional study was done on 340 women aged 45-60 years in Tabriz, northwest Iran, during 2015-2016. Data were collected using a demographic data questionnaire, the Overactive Bladder Syndrome Score, and the McCoy Female Sexuality Questionnaire...
December 4, 2017: Urologia
https://www.readbyqxmd.com/read/29216920/body-mass-index-had-different-effects-on-premenopausal-and-postmenopausal-breast-cancer-risks-a-dose-response-meta-analysis-with-3-318-796-subjects-from-31-cohort-studies
#16
Yanzi Chen, Li Liu, Quan Zhou, Mustapha Umar Imam, Jialin Cai, Yaxuan Wang, Minjie Qi, Panpan Sun, Zhiguang Ping, Xiaoli Fu
BACKGROUND: There is sufficient evidence supporting a relationship between increased body mass index (BMI) and an increased risk for breast cancer among postmenopausal women. However, most studies have found a decreased risk for premenopausal breast cancer. This study was conducted to find out the different effects of BMI on the risk of breast cancer among premenopausal and postmenopausal women, and explore the potential factors that influence the associations. METHODS: A dose-response meta-analysis with 3,318,796 participants from 31 articles was conducted...
December 8, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29216870/prevalence-and-severity-of-menopause-symptoms-among-perimenopausal-and-postmenopausal-women-aged-30-49%C3%A2-years-in-gulele-sub-city-of-addis-ababa-ethiopia
#17
Engida Yisma, Natnael Eshetu, Stephanie Ly, Berhanu Dessalegn
BACKGROUND: Menopause is a natural phenomenon occurring as women approach middle-age. It is characterized by declining of ovarian function and onset of the last menstrual period and subsequent 12-month cessation of menstruation. Due to a growing aging population and longer life expectancies, sub-Saharan African women will spend a significant portion of their lives in postmenopause. Menopausal symptom research has been primarily conducted on Caucasian women from high-income countries. Understanding menopause symptom prevalence and perceptions among diverse women in Ethiopia will better inform reproductive health care...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29216853/obesity-associates-with-vasomotor-symptoms-in-postmenopause-but-with-physical-symptoms-in-perimenopause-a-cross-sectional-study
#18
Seul Koo, Younjhin Ahn, Joong-Yeon Lim, Juhee Cho, Hyun-Young Park
BACKGROUND: Middle-aged women experience various menopausal symptoms during the menopause. These symptoms can affect their quality of life and health. Several epidemiological studies reported that obesity associates with menopausal symptoms. The aim of this cross-sectional study was to examine the associations between obesity and multiple menopausal symptoms at different stages of menopause in middle-aged Korean women. METHODS: The study population included women aged 44-56 years who visited a tertiary referral hospital for medical check-ups between November 2012 and March 2013 and were free from serious illness, could comprehend a questionnaire...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29215211/a-study-of-hormonal-effects-in-cervical-smear-samples-using-raman-spectroscopy
#19
Damien Traynor, Padraig Kearney, Ines Ramos, Cara M Martin, John J O'Leary, Fiona M Lyng
Raman spectroscopy is a powerful tool that has the potential to be used as a screening method for cervical cancer. It is a label free, low cost method providing a biochemical fingerprint of a given sample. The objective of this study was to address patient to patient variability contributed by hormonal effects due to the menstrual cycle, the use of hormone based contraceptives and the onset of menopause, and to determine if these changes would affect the ability to successfully identify dyskaryotic cells. Raman spectra were recorded from unstained ThinPrep cervical samples (45 cytology negative and 15 high grade dyskaryosis (high grade squamous intraepithelial lesion (SIL)) samples using a HORIBA Jobin Yvon XploRA™ system...
December 7, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29214925/combined-exercise-training-reduces-climacteric-symptoms-without-the-additive-effects-of-isoflavone-supplementation-a-clinical-controlled-randomised-double-blind-study
#20
Juliene G Costa, Jéssica S Giolo, Igor M Mariano, Jaqueline P Batista, Ana Luiza A Ribeiro, Tállita Cristina F Souza, Erick P de Oliveira, Ana Paula M Resende, Guilherme M Puga
BACKGROUND: Exercise and supplementation with isoflavones are therapies used to prevent and treat climacteric symptoms. AIM: To verify the effects of 10 weeks of combined aerobic and resistance training and isoflavone supplementation on climacteric symptoms in postmenopausal women. METHODS: A randomised, double-blind, controlled clinical trial was performed. A total of 32 postmenopausal women, aged 54.4 ± 5.4 years, with a body mass index of 26...
December 2017: Nutrition and Health
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