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https://www.readbyqxmd.com/read/28535290/dietary-quality-and-ovarian-cancer-risk-in-african-american-women
#1
Bo Qin, Patricia G Moorman, Linda E Kelemen, Anthony J Alberg, Jill S Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Edward S Peters, Ann G Schwartz, Paul Terry, Joellen M Schildkraut, Elisa V Bandera
This study evaluated 3 index-based dietary patterns-Healthy Eating Index (HEI)-2005, HEI-2010, and Alternate Healthy Eating Index (AHEI)-2010-in relation to ovarian cancer risk in African-American women. The study was conducted among 415 ovarian cancer cases and 629 age- and site-matched controls of African-American descent recruited from the population-based African American Cancer Epidemiology Study. Multivariable unconditional logistic regression models were used to estimate odds ratios and 95% confidence intervals between quartiles of dietary quality indices and ovarian cancer risk, adjusting for potential confounders...
May 23, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28535209/aromatic-dna-adducts-and-breast-cancer-risk-a-case-cohort-study-within-the-epic-spain
#2
Antonio Agudo, Marco Peluso, Armelle Munnia, Leila Luján-Barroso, Aurelio Barricarte, Pilar Amiano, Carmen Navarro, María-José Sánchez, J Ramón Quirós, Eva Ardanaz, Nerea Larrañaga, María-José Tormo, María-Dolores Chirlaque, Miguel Rodríguez-Barranco, Emilio Sánchez-Cantalejo, Filippo Cellai, Catalina Bonet, Núria Sala, Carlos A González
Epidemiologic evidence linking environmental exposure to polycyclic aromatic hydrocarbons (PAH) with breast cancer is limited. Measurement of DNA adducts formed by aromatic compounds, including PAH, has been carried in breast tissue samples and white blood cells from women with breast cancer and different kinds of controls. However, these studies provide inconsistent results and bias cannot be ruled out. During the 7-year follow-up period, 305 women were diagnosed with first primary breast cancer in the EPIC-Spain cohort, and were compared with a sample of 149 women without breast cancer at recruitment, using a case-cohort approach...
May 23, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28534527/role-of-the-ugt2b17-deletion-in-exemestane-pharmacogenetics
#3
S Luo, G Chen, C Truica, C C Baird, K Leitzel, P Lazarus
Exemestane (EXE) is an aromatase inhibitor used for the prevention and treatment of breast cancer. The major metabolic pathway for EXE is reduction to form the active 17β-dihydro-EXE (17β-DHE) and subsequent glucuronidation to 17β-hydroxy-EXE-17-O-β-D-glucuronide (17β-DHE-Gluc) by UGT2B17. The aim of the present study was to determine the effects of UGT2B17 copy number variation on the levels of urinary and plasma 17β-DHE-Gluc and 17β-DHE in patients taking EXE. Ninety-six post-menopausal Caucasian breast cancer patients with ER+ breast tumors taking 25 mg EXE daily were recruited into this study...
May 23, 2017: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/28534020/incarceration-of-a-pedunculated-uterine-fibroid-in-an-umbilical-hernia
#4
Mi Ju Kim, Hyun-Hwa Cha, Won Joon Seong
Uterine fibroids are common benign tumors that may cause an umbilical hernia in patients with increased intra-abdominal pressure due to pregnancy, obesity, ascites, and intra-abdominal tumors. However, the simultaneous occurrence of uterine fibroids and umbilical hernias, or fibroids and an associated umbilical hernia, during pregnancy has rarely been reported. Here, we present the case of a fibroid presenting as an incarcerated umbilical hernia in a menopausal patient.
May 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28533839/-epidemiology-of-the-relationship-between-atrial-fibrillation-and-heart-failure
#5
Yassine Ragbaoui, Chafia Chehbouni, Ayoub El Hammiri, Rachida Habbal
Atrial fibrillation and heart failure are diseases which often coexist aggravating prognosis and constituting a major public health problem. The aim of this study was to assess the prevalence of atrial fibrillation in patients with chronic heart failure and to determine the clinical profile of this group of patients. We conducted a retrospective descriptive study based on the registry of heart failure of the Department of Cardiology at the University Hospital Centre from June 2006 to March 2015. All patients over 18 years of age with chronic heart failure associated with atrial fibrillation were included in the study...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28533289/treatment-with-standard-and-low-dose-of-conjugated-equine-estrogen-differentially-modulates-estrogen-receptor-expression-and-response-to-angiotensin-ii-in-mesenteric-venular-bed-of-surgically-postmenopausal-hypertensive-rats
#6
Priscila Xavier Araujo, Tiago Januario Costa, Cinthya Echem, Maria Aparecida Oliveira, Rosangela Aparecida Santos-Eichler, Lucas Giglio Colli, Francesc Jimenez-Altayo, Elisabet Vila, Eliana Hiromi Akamine, Ana Paula Dantas, Graziela Scalianti Ceravolo, Maria Helena Catelli de Carvalho
Standard hormone therapy for menopausal women [conjugated equine estrogen (CEE) 0.625 mg] has been associated with increased risk of venous thrombosis. Regimens containing lower CEE dose (0.30 mg) have been clinically used to decrease side effects of supra-physiological doses of estrogen. In this study, we determined the effects of standard (SD) and low (LD) dose of CEE on venular function in ovariectomized (OVX) spontaneously hypertensive rats (SHR). Contractions to Angiotensin-II (Ang-II 10μM) in perfused mesenteric venular bed were markedly increased in OVX (21...
May 22, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28533263/prior-weight-loss-exacerbates-the-biological-drive-to-gain-weight-after-the-loss-of-ovarian-function
#7
Vanessa D Sherk, Matthew R Jackman, Erin D Giles, Janine A Higgins, Rebecca M Foright, David M Presby, Ginger C Johnson, Julie A Houck, Jordan L Houser, Robera Oljira, Paul S MacLean
Both the history of obesity and weight loss may change how menopause affects metabolic health. The purpose was to determine whether obesity and/or weight loss status alters energy balance (EB) and subsequent weight gain after the loss of ovarian function. Female lean and obese Wistar rats were randomized to 15% weight loss (WL) or ad libitum fed controls (CON). After the weight loss period, WL rats were kept in EB at the reduced weight for 8 weeks prior to ovariectomy (OVX). After OVX, all rats were allowed to eat ad libitum until weight plateaued...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28533260/relationship-between-monocyte-platelet-aggregation-and-endothelial-function-in-middle-aged-and-elderly-adults
#8
Andrew Haynes, Matthew D Linden, Elisa Robey, Louise H Naylor, Kay L Cox, Nicola T Lautenschlager, Daniel J Green
Low-grade inflammation, endothelial dysfunction, and platelet hyper-reactivity to agonists are associated with an increased risk of cardiovascular events. In vitro and animal studies infer an inverse mechanistic relationship between platelet activation and the production of endothelium-derived nitric oxide and prostacyclin. This concept is supported by evidence of an inverse relationship between endothelial function and platelet activation in high-risk cardiac patients. The aim of this study was to investigate what relationship, if any, exists between platelet and endothelial function in healthy, middle-aged, and elderly adults...
May 2017: Physiological Reports
https://www.readbyqxmd.com/read/28532290/midlife-women-s-cardiovascular-symptoms-a-cluster-analysis
#9
Eun-Ok Im, Young Ko, Eunice Chee, Wonshik Chee, Jun James Mao
Menopausal transition, in which biological and psychosocial changes are caused due to estrogen fluctuations, has been reported to increase cardiovascular risk among midlife women. Our purpose of this study was to identify the clusters of midlife women by cardiovascular symptoms and to examine racial/ethnic differences in the clusters. This was a secondary analysis, in which hierarchical cluster and multinomial logistic analyses were conducted with the data (N = 966) collected in two previous studies. Three-clusters were adopted: Cluster 1 (high vasomotor and low cardiorespiratory), Cluster 2 (low vasomotor and high cardiorespiratory and high discomfort/pain), and Cluster 3 (high discomfort/pain and high indigestion)...
May 22, 2017: Health Care for Women International
https://www.readbyqxmd.com/read/28532219/no-sweat-managing-menopausal-symptoms-at-work
#10
Martha Hickey, Kathleen Riach, Reza Kachouie, Gavin Jack
INTRODUCTION: Menopause usually occurs between the ages of 45 and 55, a time when women are likely to be in the paid workforce. Most women have menopausal symptoms and these may impact on daytime function and work performance. This study examines the relationship between reproductive stage, menopausal symptoms and work, and advises how employers can best support menopausal women. METHODS: An online and paper-based survey was completed in 2015-16 by 1092 women (22% response rate) aged 40 years plus employed in three hospitals in metropolitan Australia...
May 22, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28531779/overweight-postmenopausal-women-with-different-plasma-estradiol-concentrations-present-with-a-similar-pattern-of-energy-expenditure-and-substrate-oxidation-rate-before-and-after-a-fatty-meal-challenge
#11
Roberta de Souza Santos, Andressa Feijó da Silva Santos, Deborah J Clegg, Odilon Iannetta, Julio Sérgio Marchini, Vivian Marques Miguel Suen
Menopause-related withdrawal of ovarian estrogens is associated with reduced energy metabolism and overall impairment of substrate oxidation. Estradiol's withdrawal after menopause is associated with a reduction in energy metabolism and impaired substrate oxidation, which contributes to weight gain and visceral fat accumulation. Here we aimed to investigate the association between plasma estradiol concentrations and energy expenditure (EE)/substrate oxidation in a group of overweight postmenopausal women before and after a fatty meal challenge...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28530481/hormone-replacement-therapy-in-pre-menopausal-women-undergoing-bilateral-salpingo-oophorectomy-for-benign-disease-a-review-of-practice
#12
Alison Richardson, Emily West, Mike Cust
Introduction The National Institute for Health and Care Excellence (NICE) guideline on the diagnosis and management of the menopause states that women who are likely to go through the menopause as a result of surgical treatment should be offered information about the menopause and the importance of starting hormonal replacement therapy before they have their treatment. Objectives To determine compliance with NICE guidelines at the Royal Derby Hospital. Study design We undertook a retrospective review of all pre-menopausal women undergoing bilateral salpingo-oophorectomy for benign pathology between 1 January 2016 and 30 June 2016...
January 1, 2017: Post Reproductive Health
https://www.readbyqxmd.com/read/28530345/-functional-somatic-syndromes-among-ethiopian-immigrants-in-israel
#13
Nimrod Grisaru, Danny Budowski, Seffefe Ayecheh, Eliezer Witztum
INTRODUCTION: The psychiatric classifications of disease (DSMIV; ICD-10) relate to a family of high incidence somatoform disorders whose use isn't uniform and cannot be measured. DSM-5 presents the term "cultural conceptualization of distress", which attempts to describe the cultural construct and its influences on mental distress and symptom presentation. Somatization among immigrants poses a diagnostic, treatment and research challenge due to cultural differences such as wrong understanding of their symptoms that may lead to misdiagnosis and to prescribing wrong and possibly harmful treatment and unnecessary hospitalization...
December 2016: Harefuah
https://www.readbyqxmd.com/read/28529739/long-term-supplementation-with-young-coconut-juice-does-not-prevent-bone-loss-but-rather-alleviates-body-weight-gain-in-ovariectomized-rats
#14
Hiroshi Matsushita, Akira Minami, Hiroaki Kanazawa, Takashi Suzuki, Sanan Subhadhirasakul, Kazushi Watanabe, Akihiko Wakatsuki
Young coconut (Cocos nucifera Linn.) juice (YCJ) has traditionally been consumed to alleviate symptoms associated with the menopause. Recently, the authors demonstrated that short-term (6-week) YCJ supplementation to ovariectomized rats resulted in increased bone mass and bone formation parameter, suggesting that YCJ consumption has a positive effect on bone metabolism and may represent an intervention to help slow the bone loss during menopause transition. The present study sought to determine how long-term (12-week) YCJ supplementation affects bone metabolism in ovariectomized rats, to investigate whether such supplementation may be helpful to in osteoporosis treatment...
May 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28528727/sexual-inactivity-in-partnered-female-cancer-survivors
#15
Jennifer L Marino, Christobel M Saunders, Martha Hickey
OBJECTIVE: To measure sexual activity in a clinic population of partnered female cancer survivors, and to better understand reasons for sexual inactivity in this population. MATERIALS AND METHODS: Partnered peri- or post-menopausal cancer survivors seen at a specialty clinic for menopause symptoms after cancer completed Fallowfield's Sexual Activity Questionnaire, quality of life measures (the Functional Assessment of Cancer Therapy General, Breast Cancer, and Endocrine Symptom Scales), and the Greene Climacteric Scale...
May 9, 2017: Maturitas
https://www.readbyqxmd.com/read/28525780/age-of-despair-or-age-of-hope-palestinian-women-s-perspectives-on-midlife-health
#16
Doaa Hammoudeh, Ernestina Coast, David Lewis, Yoke van der Meulen, Tiziana Leone, Rita Giacaman
There is limited evidence about women's experiences of the midlife, beyond a narrow - frequently biomedical - focus on the menopause. The broader (physical, social, cultural, political) dimensions of women's midlife health are poorly understood, particularly in low and middle-income countries. Our study seeks to understand how women in the West Bank (occupied Palestinian territories) conceptualise, experience and manage their health in the midlife. We generated qualitative evidence using in-depth life history interviews in 2015 with women (n = 35) living in the West Bank, analysed thematically...
May 11, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28525646/sleep-during-menopausal-transition-a-six-year-follow-up
#17
Laura Lampio, Päivi Polo-Kantola, Sari-Leena Himanen, Samu Kurki, Eero Huupponen, Janne Engblom, Olli J Heinonen, Olli Polo, Tarja Saaresranta
Study Objectives: Menopausal transition is associated with increased dissatisfaction with sleep, but the effects on sleep architecture are conflicting. This prospective six-year follow-up study was designed to evaluate the changes in sleep stages and sleep continuity that occur in women during menopausal transition. Methods: Sixty women (mean age 46.0 years, SD 0.9) participated. All women were premenopausal at baseline, and at the six-year follow-up, women were in different stages of menopausal transition...
May 19, 2017: Sleep
https://www.readbyqxmd.com/read/28525295/duration-of-reproductive-years-and-the-risk-of-cardiovascular-and-cerebrovascular-events-in-older-women-insights-from-the-national-health-and-nutrition-examination-survey
#18
Hend Mansoor, Islam Y Elgendy, Richard Segal, Abraham Hartzema
BACKGROUND: Studies have shown conflicting information regarding the association between the age at menarche and/or menopause and cardiovascular and cerebrovascular diseases in older women. This study aimed to determine whether a longer duration of reproductive years in older women in the U.S. population was associated with a lower risk of cardiovascular and cerebrovascular diseases. MATERIALS AND METHODS: Women ≥60 years who participated in the National Health and Nutrition Examination Survey from 2007 to 2012 were included...
May 19, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28523945/prevention-of-postmenopausal-osteoporosis-in-chinese-women-a-5-year-double-blind-randomized-parallel-placebo-controlled-study
#19
S Y Ran, Q Yu, Y Chen, S Q Lin
OBJECTIVES: To observe the effectiveness and safety of menopause-related hormone therapy (MHT) to prevent bone loss in Chinese women during the menopausal transition and early menopause, as well as to evaluate the effects of 5-year MHT on overall health to add Level I evidence for the prevention of osteoporosis using MHT. DESIGN: This clinical study was a prospective, double-blind, randomized, parallel placebo-controlled study. Chinese women in the menopausal transition and early menopause were randomly allocated to the MHT group or the placebo group...
May 19, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/28523400/long-term-effect-of-thermoablative-fractional-co2-laser-treatment-as-a-novel-approach-to-urinary-incontinence-management-in-women-with-genitourinary-syndrome-of-menopause
#20
Pablo González Isaza, Kinga Jaguszewska, Jose Luis Cardona, Mariusz Lukaszuk
INTRODUCTION AND HYPOTHESIS: The aim of this study was to evaluate the long-term effect of thermoablative fractional CO2 laser (TACO2L) as an alternative treatment for early stages of stress urinary incontinence (SUI) in postmenopausal women with genitourinary syndrome of menopause. METHODS: A total of 161 postmenopausal patients (age 53.38 ± 5.1 years, range 45-65 years) with a clinical diagnosis of mild SUI were prospectively enrolled in the study. Patients received one treatment with TACO2L every 30-45 days, each treatment comprising four sessions, followed in all patients by a yearly treatment session at 12, 24 and 36 months...
May 18, 2017: International Urogynecology Journal
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