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Early normal puberty

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https://www.readbyqxmd.com/read/29903301/-determination-of-polycyclic-aromatic-hydrocarbons-in-girls-and-association-between-polycyclic-aromatic-hydrocarbons-exposure-and-puberty-timing
#1
Xu Deng, Qin Liu, Shudan Liu, Wenyan Li, Yiwen Chen, Yi Wen, Yan Luo
OBJECTIVE: To develop amethod for simultaneous determination of four metabolites of polycyclic aromatic hydrocarbons( PAHs), and to study the association between puberty timing of girls and PAHs exposure levels in Chongqing. METHODS: Through purposeful sampling, questionnaire survey of the general information, physical examination of growth and development, collection of urine sample were carried out among1-4 grades of four primary school girls in a district of Chongqing...
September 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29894894/excess-deposition-of-collagen-in-mammary-glands-of-tamoxifen-treated-holstein-heifers-is-associated-with-impaired-mammary-growth
#2
H L M Tucker, J Holdridge, C L M Parsons, R M Akers
It is established that the ovary and estrogen are essential to bovine mammary development with the onset of puberty. Recent studies have shown that ovariectomy in the very early prepubertal period, well before onset of puberty, also dramatically impairs mammary growth. Similarly, prepubertal heifers treated with the antiestrogen tamoxifen (TAM) also exhibit markedly impaired mammary growth in correspondence with reduced estrogen receptor α (ESR1) expression. Our objective was to evaluate the effect of TAM on the mammary stroma and specifically to determine if the reported decrease in mammary development was related to changes in TAM-induced alterations in the stroma surrounding the mammary parenchyma...
May 18, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29860321/premature-ovarian-insufficiency-and-early-depletion-of-the-ovarian-reserve-in-the-monogenic-mulibrey-nanism-disorder
#3
Susann Karlberg, Aila Tiitinen, Henrik Alfthan, Marita Lipsanen-Nyman
STUDY QUESTION: What is the timing of onset and clinical course of premature ovarian insufficiency (POI) in patients with Mulibrey nanism (MUL), a monogenic disorder caused by mutations of the peroxisomal TRIM37 gene? SUMMARY ANSWER: The number of ovarian follicles is highly reduced already in infant and young MUL girls and the majority of them will have early depletion of follicles resulting in clinical and biochemical signs of POI. WHAT IS KNOWN ALREADY: Both female and male patients with MUL show failure of sexual maturation, signs of hypogonadism and infertility...
June 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29801469/analysis-of-the-pvuii-and-xbai-polymorphisms-in-the-estrogen-receptor-alpha-gene-in-girls-with-central-precocious-puberty-a-pilot-study
#4
José Maria Soares-Jr, Felisbela Soares de Holanda, Cézar Noboru Matsuzaki, Isabel Cristina Esposito Sorpreso, Eduardo Carvalho de Arruda Veiga, Luiz Carlos de Abreu, Kátia Cândido Carvalho, Edmund Chada Baracat
BACKGROUND: Precocious puberty (PP) is defined as premature pubertal development. Its consequences surpass the physical evidence of sexual maturity with the premature epiphyseal closure of the long bones and the reduction of adult stature by varied degrees. Central PP is characteristically dependent on GnRH and most of its causes are not completely known. Altered estrogen action is also believed to be involved in the genesis of PP. In fact, estrogen receptor alpha (Rea) gene polymorphisms may be associated with early age at menarche...
May 25, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29769822/maturity-status-strongly-influences-the-relative-age-effect-in-international-elite-under-9-soccer
#5
Lisa Müller, Josef Gehmaier, Christoph Gonaus, Christian Raschner, Erich Müller
The aim of the study was to assess the role of the relative age effect (RAE) and to investigate the influence of the biological maturity status on the RAE in international under-9 soccer. The birth dates of 222 male participants of the U9 Eurochampionship Soccer Tournament in Vienna in 2016 were analyzed and divided into four relative age quarters (Q1-Q4) and the biological maturity status was assessed with the age at peak height velocity (APHV) method. Based on the mean±standard deviation of the APHV, the athletes were divided into three groups of maturity: early, normal and late maturing...
June 2018: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/29730657/adolescent-undernutrition-global-burden-physiology-and-nutritional-risks
#6
Parul Christian, Emily R Smith
Adolescents, comprised of 10-19 year olds, form the largest generation of young people in our history. There are an estimated 1.8 billion adolescents in the world, with 90% residing in low- and middle-income countries. The burden of disease among adolescents has its origins in infectious and injury-related causes, but nutritional deficiencies, suboptimal linear growth, and undernutrition are major public health problems, even as overweight may be on the rise in many contexts. Summary and Key Messages: Girls are most vulnerable to the influences of cultural and gender norms, which often discriminate against them...
2018: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29730183/genes-underlying-delayed-puberty
#7
REVIEW
S R Howard
The genetic control of pubertal timing has been a field of active investigation for the last decade, but remains a fascinating and mysterious conundrum. Self-limited delayed puberty (DP), also known as constitutional delay of growth and puberty, represents the extreme end of normal pubertal timing, and is the commonest cause of DP in both boys and girls. Familial self-limited DP has a clear genetic basis. It is a highly heritable condition, which often segregates in an autosomal dominant pattern (with or without complete penetrance) in the majority of families...
May 3, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29708396/evaluation-of-characteristics-of-the-craniofacial-complex-and-dental-maturity-in-girls-with-central-precocious-puberty
#8
Hee-Kyung Lee, Sung-Hwan Choi, Dong Fan, Kyung-Mi Jang, Min-Seon Kim, Chung-Ju Hwang
OBJECTIVES: To identify unique characteristics of the craniofacial complex and dental maturity in girls with central precocious puberty (CPP). MATERIALS AND METHODS: This study included 34 Korean girls with idiopathic CPP (mean age, 8.6 ± .5 years) and 28 normal healthy girls of the same chronological age. An initial evaluation of the growth pattern of the craniofacial complex and dental maturity was conducted by analyzing lateral cephalometric and panoramic radiographs...
April 30, 2018: Angle Orthodontist
https://www.readbyqxmd.com/read/29705181/-natural-progression-of-premature-pubarche-and-underlying-diseases
#9
María Luisa Sancho Rodríguez, Gloria Bueno Lozano, José Ignacio Labarta Aizpún, Antonio de Arriba Muñoz
INTRODUCTION: Premature pubarche (PP) is generally thought to be a benign condition, but it can also be the first sign of underlying disease. OBJECTIVE: To analyse the aetiology and the evolution of the anthropometric, analytical and metabolic risk parameters of a group of patients with PP. MATERIAL AND METHODS: A descriptive and analytical retrospective study of 92 patients affected by PP. Anthropometry, analyses, bone age and indicators of lipid metabolism were all evaluated...
April 25, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29687293/psychosocial-stress-exposure-disrupts-mammary-gland-development
#10
Marianna B Johnson, Joscelyn N Hoffmann, Hannah M You, Ricardo R Lastra, Sully Fernandez, Jordan W Strober, Ahmad B Allaw, Matthew J Brady, Suzanne D Conzen, Martha K McClintock
Exposure to psychosocial stressors and ensuing stress physiology have been associated with spontaneous invasive mammary tumors in the Sprague-Dawley rat model of human breast cancer. Mammary gland (MG) development is a time when physiologic and environmental exposures influence breast cancer risk. However, the effect of psychosocial stress exposure on MG development remains unknown. Here, in the first comprehensive longitudinal study of MG development in nulliparous female rats (from puberty through young adulthood; 8-25 wks of age), we quantify the spatial gradient of differentiation within the MG of socially stressed (isolated) and control (grouped) rats...
June 2018: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/29684167/reproduction-in-domestic-ruminants-during-the-past-50-years-discovery-to-application
#11
Michael F Smith, Rodney D Geisert, John J Parrish
The study of reproductive physiology in domestic ruminants has progressed from the whole animal to the molecular level in an amazingly short period of time. The volume of information on this subject is enormous; therefore, we have focused on domestic ruminants, with an emphasis on cattle. To date, artificial insemination (AI) is perhaps the most powerful technique that reproductive physiologists and geneticists have provided the livestock industry for genetic improvement. Early efforts to establish AI as a tool were initiated in Russia around 1899 and since that time major advances in methods of semen collection, evaluation of male fertility, cryopreservation of sperm, sex-sorted semen, and estrous cycle control have occurred...
April 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29684126/when-does-germ-cell-loss-and-fibrosis-occur-in-patients-with-klinefelter-syndrome
#12
D Van Saen, V Vloeberghs, I Gies, I Mateizel, K Sermon, Jean De Schepper, H Tournaye, E Goossens
STUDY QUESTION: When does germ cell loss and fibrosis occur in patients with Klinefelter syndrome (KS)? SUMMARY ANSWER: In KS, germ cell loss is not observed in testicular tissue from fetuses in the second semester of pregnancy but present at a prepubertal age when the testicular architecture is still normal, while fibrosis is highly present at an adolescent age. WHAT IS KNOWN ALREADY: Most KS patients are azoospermic at adult age because of a massive germ cell loss...
June 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29680294/klinefelter-syndrome-the-effects-of-early-androgen-therapy-on-competence-and-behavioral-phenotype
#13
REVIEW
Ryan Flannigan, Premal Patel, Darius A Paduch
INTRODUCTION: Klinefelter syndrome (KS) is the result of sex chromosome aneuploidy most often characterized as 47,XXY. The typical features of KS include tall stature, gynecomastia, small firm testicles, hypergonadotropic hypogonadism, and infertility. However, abnormalities in neurodevelopment, cognition, and social and behavioral functioning also can be present. The abnormalities in neurodevelopment are believed to be due in part to androgen deficiency during early development and puberty...
April 18, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29618062/45-x-46-xy-mosaicism-presenting-with-isolated-unilateral-cryptorchidism-and-a-normal-blood-karyotype
#14
Grazia Morandi, Manuela Cerbone, Elisa B Lamback, Eleni Rapti, Mehul T Dattani
Context: 45,X/46,XY mosaicism is a disorder of sex development leading to abnormal gonadal development and to unpredictable genital phenotype, growth and pubertal development. Case Description: A two year old male presented with a right impalpable testis. Blood karyotype was 46,XY. A laparoscopy performed for right orchidopexy revealed a right streak gonad with Mullerian structures, while on the left side a normal descended testis was present. The karyotype of the removed gonad was 45,X/46,XY...
March 30, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29618044/analysis-of-sensitive-periods-of-fetal-and-child-growth
#15
Xun Zhang, Kate Tilling, Richard M Martin, Emily Oken, Ashley I Naimi, Izzuddin M Aris, Seungmi Yang, Michael S Kramer
Background: Birth weight and weight gain in infancy and early childhood are commonly studied as risk factors for later cardiometabolic diseases. In this study, we explore methods for quantifying weight gain during different age periods and for comparing the magnitude of the associations with later blood pressure. Methods: Based on data from a birth cohort study nested within a large cluster-randomized trial with repeated measures of weight from birth to 16 years of age, we compared the results of four analytic approaches to assess sensitive periods of growth in relation to blood pressure at age 16 years...
April 2, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29617589/change-in-overweight-from-childhood-to-early-adulthood-and-risk-of-type-2-diabetes
#16
Lise G Bjerregaard, Britt W Jensen, Lars Ängquist, Merete Osler, Thorkild I A Sørensen, Jennifer L Baker
BACKGROUND: Childhood overweight is associated with an increased risk of type 2 diabetes in adulthood. We investigated whether remission of overweight before early adulthood reduces this risk. METHODS: We conducted a study involving 62,565 Danish men whose weights and heights had been measured at 7 and 13 years of age and in early adulthood (17 to 26 years of age). Overweight was defined in accordance with Centers for Disease Control and Prevention criteria. Data on type 2 diabetes status (at age ≥30 years, 6710 persons) were obtained from a national health registry...
April 5, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29575542/the-stressed-brain-of-humans-and-rodents
#17
REVIEW
M Joëls, H Karst, R A Sarabdjitsingh
After stress, the brain is exposed to waves of stress mediators, including corticosterone (in rodents) and cortisol (in humans). Corticosteroid hormones affect neuronal physiology in two time-domains: rapid, non-genomic actions primarily via mineralocorticoid receptors; and delayed genomic effects via glucocorticoid receptors. In parallel, cognitive processing is affected by stress hormones. Directly after stress, emotional behaviour involving the amygdala is strongly facilitated with cognitively a strong emphasis on the "now" and "self," at the cost of higher cognitive processing...
June 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29554994/review-the-effect-of-nutrition-on-timing-of-pubertal-onset-and-subsequent-fertility-in-the-bull
#18
D A Kenny, C J Byrne
The advent of genomic selection has led to increased interest within the cattle breeding industry to market semen from young bulls as early as possible. However, both the quantity and quality of such semen is dictated by the age at which these animals reach puberty. Enhancing early life plane of nutrition of the bull stimulates a complex biochemical interplay involving metabolic and neuroendocrine signalling and culminating in enhanced testicular growth and development and earlier onset of sexual maturation...
March 20, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29529566/determining-the-presence-of-chemicals-with-suspected-endocrine-activity-in-drinking-water-from-the-madrid-region-spain-and-assessment-of-their-estrogenic-androgenic-and-thyroidal-activities
#19
Y Valcárcel, A Valdehíta, E Becerra, M López de Alda, A Gil, M Gorga, M Petrovic, D Barceló, J M Navas
Endocrine disruptors (EDs) are natural or man-made chemicals that can affect the health of organisms by interfering with their normal hormonal functions. Many of these substances can cause their effects at very low doses and, considering the key role played by the endocrine system on development, organisms in early phases of growth (foetal, childhood, puberty) are especially sensitive to the action of EDs. In addition, when combined, they can show additive, antagonistic and synergistic activities. Taking all this into account it is essential to determine the presence of this kind of compounds in drinking water...
June 2018: Chemosphere
https://www.readbyqxmd.com/read/29525066/-diffuse-hypertrichosis-revealing-non-classical-congenital-adrenal-hyperplasia
#20
C Berthin, P Sibilia, J Martins-Hericher, A Donzeau, L Martin
BACKGROUND: Non-classical congenital adrenal hyperplasia (NC-CAH) is a recessive autosomal disease caused by a deficiency of adrenal steroidogenesis enzymes. It must be distinguished from classical CAH, either simple virilising or salt-wasting, diagnosed during the neonatal period and responsible for potentially lethal disorders of sexual differentiation. NC-CAH presents a simpler and less specific clinical picture. Herein, we present two cases comprising twin girls consulting for diffuse hypertrichosis...
April 2018: Annales de Dermatologie et de Vénéréologie
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