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https://www.readbyqxmd.com/read/27829479/metabolic-and-reproductive-characteristics-of-replacement-beef-heifers-subjected-to-an-early-weaning-regimen-involving-high-concentrate-feeding
#1
A L Zezeski, V L McCracken, R K Poole, A Al Naib, J K Smith, M A McCann, M L Rhoads
In an effort to better understand the consequences of early weaning (EW) for replacement beef heifers, a two-phase experiment was conducted investigating the impact on metabolic function and documenting reproductive characteristics. In phase 1, Angus×Simmental heifers (n=35) were stratified by BW and sire, and randomly assigned to either a normal weaning (NW, n=18) or EW (n=17) treatment. EW heifers were weaned at 107±3 days of age and provided access to a concentrate-based ration ad libitum with limit-fed mixed grass hay...
November 10, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27825136/pubertal-and-adult-windows-of-susceptibility-to-a-high-animal-fat-diet-in-trp53-null-mammary-tumorigenesis
#2
Yirong Zhu, Mark D Aupperlee, Yong Zhao, Ying Siow Tan, Erin L Kirk, Xuezheng Sun, Melissa A Troester, Richard C Schwartz, Sandra Z Haslam
Premenopausal breast cancer is associated with increased animal fat consumption among normal weight, but not overweight women (Farvid et al., 2014). Our previous findings in obesity-resistant BALB/c mice similarly showed promotion of carcinogen-induced mammary tumorigenesis by a diet high in saturated animal fat (HFD). This effect was specific to pubertal versus adult HFD. This study identifies the effects of HFD during puberty versus adulthood in Trp53-null transplant BALB/c mice and investigates its mechanism of enhancing tumorigenesis...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27787478/dysfunctional-uterine-bleeding-as-an-early-sign-of-polycystic-ovary-syndrome-during-adolescence-an-update
#3
Efthimios Deligeoroglou, Vasileios Karountzos
AIM: Abnormal Uterine Bleeding (AUB) is a frequent reason for concern between adolescents. The most common cause of AUB in these girls, when other pathologies have been excluded, is Dysfunctional Uterine Bleeding (DUB). The aim of this review is to assess the role of DUB as an early symptom of Polycystic Ovarian Syndrome (PCOS) diagnosis later in life. METHODS: Review of the literature, using Pubmed and Medline as primary databases, regarding the correlation between DUB cases early after menarche and PCOS diagnosis in the future...
October 27, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27773998/multiple-effects-of-growth-hormone-in-the-body-is-it-really-the-hormone-for-growth
#4
REVIEW
Jesús Devesa, Cristina Almengló, Pablo Devesa
In this review, we analyze the effects of growth hormone on a number of tissues and organs and its putative role in the longitudinal growth of an organism. We conclude that the hormone plays a very important role in maintaining the homogeneity of tissues and organs during the normal development of the human body or after an injury. Its effects on growth do not seem to take place during the fetal period or during the early infancy and are mediated by insulin-like growth factor I (IGF-I) during childhood and puberty...
2016: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/27747183/pectus-excavatum-from-a-pediatric-surgeon-s-perspective
#5
Donald Nuss, Robert J Obermeyer, Robert E Kelly
Historically, pectus excavatum (PE) was reported to be congenital, but in our experience only 22% are noticed in the first decade of life. Thus far, genetic studies support an autosomal recessive heritability, which coincides with only 40% of our patients having some positive family history, but is also contradictory given a constant sex ratio of 4:1 in favor of males. This inconsistency may be explained by the effect of more than one pectus disease-associated allele. Once the deformity is noticed, it tends to progress slowly until puberty, when rapid progression is often seen...
September 2016: Annals of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27676716/dystonia-of-the-lower-limb-after-sacral-neuromodulation-implanted-to-a-16-year-old-boy-with-non-obstructive-chronic-urinary-retention
#6
Teng Maëlys, Gilberte Robain, Samy Bendaya
OBJECTIVE: Sacral neuromodulation is usually used to treat non-obstructive urinary retention when other forms of treatment have failed. An improvement greater than 50% in urinary symptoms after 40months of follow-up has been shown: - moreover, it also has few complications: infections, technical failures, discomfort; - we report a case of dystonia of the lower limb, appeared after sacral neuromodulation implantation. OBSERVATIONS: MMP is a 16-year-old boy with early puberty as noteworthy medical history...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27611179/testicular-function-during-puberty-and-young-adulthood-in-patients-with-klinefelter-s-syndrome-with-and-without-spermatozoa-in-seminal-fluid
#7
J Rohayem, E Nieschlag, M Zitzmann, S Kliesch
Patients with Klinefelter's syndrome experience progressive testicular degeneration resulting in impaired endocrine function and azoospermia. What proportion of adolescents develop testosterone deficiency during puberty and how many have spermatozoa in their semen is unclear to date. We aimed to investigate testicular function during puberty and young adulthood in patients with Klinefelter's syndrome and to assess testosterone effects in target tissues. The clinical data of 281 patients with non-mosaic Klinefelter's syndrome aged 10-25 years without previous testosterone replacement were reviewed...
September 9, 2016: Andrology
https://www.readbyqxmd.com/read/27605428/unusual-x-chromosome-inactivation-pattern-in-patients-with-xp11-23-p11-22-duplication-report-and-review
#8
Adriana Di-Battista, Vera Ayres Meloni, Magnus Dias da Silva, Mariana Moysés-Oliveira, Maria Isabel Melaragno
In females carrying structural rearrangements of an X-chromosome, cells with the best dosage balance are preferentially selected, frequently resulting in a skewed inactivation pattern and amelioration of the phenotype. The Xp11.23-p11.22 region is involved in a recently described microduplication syndrome associated with severe clinical consequences in males and females, causing intellectual disability, behavior problems, epilepsy with electroencephalogram anomalies, minor facial anomalies, and early onset of puberty...
September 8, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27585961/diagnosis-and-management-of-silver-russell-syndrome-first-international-consensus-statement
#9
Emma L Wakeling, Frédéric Brioude, Oluwakemi Lokulo-Sodipe, Susan M O'Connell, Jennifer Salem, Jet Bliek, Ana P M Canton, Krystyna H Chrzanowska, Justin H Davies, Renuka P Dias, Béatrice Dubern, Miriam Elbracht, Eloise Giabicani, Adda Grimberg, Karen Grønskov, Anita C S Hokken-Koelega, Alexander A Jorge, Masayo Kagami, Agnes Linglart, Mohamad Maghnie, Klaus Mohnike, David Monk, Gudrun E Moore, Philip G Murray, Tsutomu Ogata, Isabelle Oliver Petit, Silvia Russo, Edith Said, Meropi Toumba, Zeynep Tümer, Gerhard Binder, Thomas Eggermann, Madeleine D Harbison, I Karen Temple, Deborah J G Mackay, Irène Netchine
This Consensus Statement summarizes recommendations for clinical diagnosis, investigation and management of patients with Silver-Russell syndrome (SRS), an imprinting disorder that causes prenatal and postnatal growth retardation. Considerable overlap exists between the care of individuals born small for gestational age and those with SRS. However, many specific management issues exist and evidence from controlled trials remains limited. SRS is primarily a clinical diagnosis; however, molecular testing enables confirmation of the clinical diagnosis and defines the subtype...
September 2, 2016: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/27564696/pattern-of-menarche-age-normal-early-and-late-and-its-relationship-with-some-demographic-characteristics-in-girls-and-their-parents
#10
Naeimeh Tayebi, Zahra Yazdznpanahi, Shahrzad Yektatalab, Marzieh Akbarzadeh, Najaf Zare
BACKGROUND: Menarche age is an indicator of a girl's puberty besides the clinical assessment of detecting deviations. This study aimed to search the pattern of menarche age (normal, early and late) and its relationship with some demographic characteristics in girls and their parents. METHODS: This cross-sectional study was done on girls aged between 9 and 18 years old in Shiraz city. About 2000 students were selected through cluster sampling. Data collection was done by applying a demographic information form...
August 26, 2016: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/27478869/developmental-exposure-to-endocrine-disrupting-chemicals-alters-the-epigenome-identification-of-reprogrammed-targets
#11
Lauren Prusinski, Ayman Al-Hendy, Qiwei Yang
Endocrine disruptions induced by environmental toxicants have placed an immense burden on society to properly diagnose, treat and attempt to alleviate symptoms and disease. Environmental exposures during critical periods of development can permanently reprogram normal physiological responses, thereby increasing susceptibility to disease later in life - a process known as developmental reprogramming. During development, organogenesis and tissue differentiation occur through a continuous series of tightly-regulated and precisely-timed molecular, biochemical and cellular events...
July 2016: Gynecology and Obstetrics Research: Open Journal
https://www.readbyqxmd.com/read/27467188/testicular-growth-and-spermatogenesis-new-goals-for-pubertal-hormone-replacement-in-boys-with-hypogonadotrophic-hypogonadism-a-multicentre-prospective-study-of-hcg-rfsh-treatment-outcomes-during-adolescence
#12
Julia Rohayem, Berthold P Hauffa, Margaret Zacharin, Sabine Kliesch, Michael Zitzmann
CONTEXT/OBJECTIVE: Testosterone treatment for pubertal induction in boys with hypogonadotrophic hypogonadism (HH) provides virilisation, but does not induce testicular growth or fertility. Larger studies evaluating the outcomes of gonadotrophin replacement during adolescence have not been reported to date; whether previous testosterone substitution affects testicular responses is unresolved. We aimed to assess the effects of human chorionic gonadotrophin (hCG) and recombinant FSH (rFSH) in boys and adolescents with HH with respect to a) testicular growth, b) spermatogenesis, c) quality of life (QoL) and to identify factors influencing therapeutic success...
July 28, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27464647/pubertal-development-in-children-with-chronic-kidney-disease
#13
Dieter Haffner, Miroslav Zivicnjak
Impairment of pubertal growth and sexual maturation resulting in reduced adult height is an significant complication in children suffering from chronic kidney disease (CKD). Delayed puberty and reduced pubertal growth are most pronounced in children with pre-existing severe stunting before puberty, requiring long-term dialysis treatment, and in transplanted children with poor graft function and high glucocorticoid exposure. In pre-dialysis patients, therapeutic measures to improve pubertal growth are limited and mainly based on the preservation of renal function and the use of growth hormone treatment...
July 27, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/27444748/changes-in-body-mass-index-during-gonadotropin-releasing-hormone-agonist-treatment-for-central-precocious-puberty-and-early-puberty
#14
Hae Sang Lee, Jong Seo Yoon, Jung Ki Roh, Jin Soon Hwang
Gonadotropin-releasing hormone agonists (GnRHa) have been widely used for decades to treat patients with central precocious puberty (CPP). Several studies have investigated changes in body composition in patients with CPP following GnRHa treatment, but the results are inconsistent. The aim of this study was to investigate changes in body mass index (BMI) in children treated with GnRHa for 2 years. We also assessed whether BMI affects treatment outcomes. This study included 383 girls (214 girls with central precocious puberty and 169 girls who underwent early puberty) treated with depot leuprolide acetate monthly for at least 2 years...
July 22, 2016: Endocrine
https://www.readbyqxmd.com/read/27423540/commentary-on-the-special-issue-on-the-adolescent-brain-adolescence-trajectories-and-the-importance-of-prevention
#15
Susan L Andersen
Adolescence as highlighted in this special issue is a period of tremendous growth, synaptic exuberance, and plasticity, but also a period for the emergence of mental illness and addiction. This commentary aims to stimulate research on prevention science to reduce the impact of early life events that often manifest during adolescence. By promoting a better understanding of what creates a normal and abnormal trajectory, the reviews by van Duijvenvoorde et al., Kilford et al., Lichenstein et al., and Tottenham and Galvan in this special issue comprehensively describe how the adolescent brain develops under typical conditions and how this process can go awry in humans...
November 2016: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/27412247/klinefelter-syndrome-and-fertility-sperm-preservation-should-not-be-offered-to-children-with-klinefelter-syndrome
#16
REVIEW
S Franik, Y Hoeijmakers, K D'Hauwers, D D M Braat, W L M Nelen, D Smeets, H L Claahsen-van der Grinten, L Ramos, K Fleischer
STUDY QUESTION: Should fertility preservation be offered to children with Klinefelter syndrome (KS)? SUMMARY ANSWER: Current evidence shows that fertility preservation should not be offered to adolescents with KS younger than 16 years because of lower retrieval rates for germ cells by testicular sperm extraction (TESE) compared with retrieval rates for adolescents and adults between 16 and 30 years. WHAT IS KNOWN ALREADY: KS, the most common chromosomal disorder in men leading to non-obstructive azoospermia, is caused by the presence of at least one additional X chromosome...
September 2016: Human Reproduction
https://www.readbyqxmd.com/read/27355207/targeted-mutagenesis-of-the-hypophysiotropic-gnrh3-in-zebrafish-danio-rerio-reveals-no-effects-on-reproductive-performance
#17
Olivia Smith Spicer, Ten-Tsao Wong, Nilli Zmora, Yonathan Zohar
Gnrh is the major neuropeptide regulator of vertebrate reproduction, triggering a cascade of events in the pituitary-gonadal axis that result in reproductive competence. Previous research in mice and humans has demonstrated that Gnrh/GNRH null mutations result in hypogonadotropic hypogonadism and infertility. The goal of this study was to eliminate gnrh3 (the hypophysiotropic Gnrh form) function in zebrafish (Danio rerio) to determine how ontogeny and reproductive performance are affected, as well as factors downstream of Gnrh3 along the reproductive axis...
2016: PloS One
https://www.readbyqxmd.com/read/27338787/normal-growth-altered-growth-study-of-the-relationship-between-harris-lines-and-bone-form-within-a-post-medieval-plague-cemetery-dendermonde-belgium-16th-century
#18
Alexandra Boucherie, Dominique Castex, Caroline Polet, Sacha Kacki
OBJECTIVES: Harris lines (HLs) are defined as transverse, mineralized lines associated with temporary growth arrest. In paleopathology, HLs are used to reconstruct health status of past populations. However, their etiology is still obscure. The aim of this article is to test the reliability of HLs as an arrested growth marker by investigating their incidence on human metrical parameters. METHODS: The study was performed on 69 individuals (28 adults, 41 subadults) from the Dendermonde plague cemetery (Belgium, 16th century)...
June 24, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27318548/long-term-functional-outcomes-after-penoscrotal-hypospadias-repair-a-retrospective-comparative-study-of-proximal-tip-onlay-and-duckett
#19
Pierre-Alain Hueber, Monica Salgado Diaz, Yann Chaussy, Julie Franc-Guimond, Diego Barrieras, Anne-Marie Houle
INTRODUCTION: A variety of techniques are available for proximal hypospadias repair. Onlay, proximal tubularized incised plate (TIP), and Duckett are among the popular choices because they can be performed as a one-step procedure. However, the decision to select a procedure often comes down to the surgeon's preference rather than that supported by evidence-based data. In particular, there is a paucity of literature on the long-term urinary outcomes after proximal hypospadias repair. OBJECTIVE: The aim of this study was to evaluate the evolution of long-term uroflowmetry parameters after proximal hypospadias surgery over a long-term follow-up including the adolescent period...
August 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27244789/pubertal-height-growth-and-adult-height-in-cystic-fibrosis-after-newborn-screening
#20
Zhumin Zhang, Mary J Lindstrom, Philip M Farrell, HuiChuan J Lai
BACKGROUND: To examine long-term growth benefit of newborn screening (NBS), adolescent peak height velocity (PHV), and adult height were compared between the screened (diagnosed early via NBS) and the control (identified generally by symptoms) in the Wisconsin Randomized Clinical Trial. METHODS: Data from 107 children born in 1985-1994 and followed through 2012 were analyzed. PHV was estimated by a semiparametric growth curve model and compared with Tanner reference...
May 2016: Pediatrics
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