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https://www.readbyqxmd.com/read/29913419/bacterial-toxicity-of-exfoliated-black-phosphorus-nanosheets
#1
Zhiqiang Xiong, Xuejiao Zhang, Siyu Zhang, Lei Lei, Wei Ma, Dengyu Li, Weidong Wang, Qing Zhao, Baoshan Xing
Newly emerged two-dimensional material, black phosphorus (BP) shows promising applications in many fields owing to its superior properties. Despite the biological effects of BP were studied, its environmental impacts have not yet received enough attention. In this study, the bacterial toxicity of exfoliated BP nanosheets was for the first time evaluated against two model bacteria strains, Gram-negative Escherichia coli (E. coli) and Gram-positive Bacillus subtilis (B. subtilis). By monitoring the bacterial growth curve and colony counting, the bacterial toxicity of BP nanosheets was examined...
June 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29912993/plasmatic-membrane-toll-like-receptor-expressions-in-human-astrocytomas
#2
Isabele Fattori Moretti, Daiane Gil Franco, Thais Fernanda de Almeida Galatro, Sueli Mieko Oba-Shinjo, Suely Kazue Nagahashi Marie
Toll-like receptors (TLRs) are the first to identify disturbances in the immune system, recognizing pathogens such as bacteria, fungi, and viruses. Since the inflammation process plays an important role in several diseases, TLRs have been considered potential therapeutic targets, including treatment for cancer. However, TLRs' role in cancer remains ambiguous. This study aims to analyze the expression levels of plasmatic cell membrane TLRs (TLR1, TLR2, TLR4, TLR5, and TLR6) in human astrocytomas the most prevalent tumors of CNS different grades (II-IV)...
2018: PloS One
https://www.readbyqxmd.com/read/29912330/archaeal-cell-surface-biogenesis
#3
Mechthild Pohlschroder, Friedhelm Pfeiffer, Stefan Schulze, Mohd Farid Abdul Halim
Cell surfaces are critical for diverse functions across all domains of life, from cell-cell communication and nutrient uptake to cell stability and surface attachment. While certain aspects of the mechanisms supporting the biosynthesis of the archaeal cell surface are unique, likely due to important differences in cell surface compositions between domains, others are shared with bacteria or eukaryotes or both. Based on recent studies completed on a phylogenetically diverse array of archaea, from a wide variety of habitats, here we discuss advances in the characterization of mechanisms underpinning archaeal cell surface biogenesis...
June 15, 2018: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29911287/synthesis-and-application-of-triclosan-methacrylate-monomer-in-resin-composites
#4
Andreia Bolzan de Paula, Jesus Roberto Taparelli, Roberta Caroline Bruschi Alonso, Lúcia Helena Innocentini-Mei, Regina M Puppin-Rontani
OBJECTIVES: To evaluate the antibacterial activity, bacterial viability, cytotoxicity, and mechanical/physical properties of a novel methacrylate triclosan-derivative monomer (TM) incorporated in dental resin composite. METHODS: TM was synthesized by esterification and, after characterization by FT-IR, was added to an experimental composite. Samples were divided into two groups according to TM presence, i.e., C1 (control) and C2 (C1 + 14.4% TM). Microbiological properties: Specimens (C1 and C2) were prepared and placed on bacterial suspensions of Streptococcus mutans...
June 18, 2018: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29911241/green-synthesis-of-catalytic-gold-bismuth-oxyiodide-nanocomposites-with-oxygen-vacancies-for-treatment-of-bacterial-infections
#5
Chia-Lun Hsu, Yu-Jia Li, Hong-Jyuan Jian, Scott G Harroun, Shih-Chun Wei, Rini Ravindranath, Jui-Yang Lai, Chih-Ching Huang, Huan-Tsung Chang
We have developed a simple and green solution for the synthesis of catalytic gold-doped bismuth oxyiodide (Au/BiOI) nanocomposites at room temperature from an aqueous mixture of gold ions, bismuth ions, and iodide ions. Au nanoparticles (NPs) were formed in situ and doped into BiOI nanosheets. The oxygen vacancies generated in BiOI give rise to its oxidase-like activity, and Au doping facilitated the reaction leading to a 4-fold higher oxidase-like activity of the Au/BiOI nanocomposite. The Au/BiOI nanocomposites showed wide spectrum antimicrobial activity not only against non-multidrug-resistant E...
June 18, 2018: Nanoscale
https://www.readbyqxmd.com/read/29910778/effects-of-1-8-cineole-on-carbohydrate-metabolism-related-cell-structure-changes-of-salmonella
#6
Yangying Sun, Xiaojun Cai, Jinxuan Cao, Zhen Wu, Daodong Pan
Salmonella is gram-negative foodborne zoonotic bacteria which triggers disease in humans. Our previous studies showed 1,8-cineole possessed remarkable antimicrobial effects on foodborne zoonotic bacteria indicating it could serve as a new source of antibiotic for Salmonella . Present study elucidated the antibacterial mechanism of 1,8-cineole by analyzing serum protein expressed by Salmonella following treatment with 1,8-cineole (0.25 mg/mL, 3 h) using isobaric tags for relative and absolute quantification (iTRAQ) with two-dimensional liquid chromatography/tandem mass spectrometry (2D-LC-MS/MS)...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29909035/bacterial-cellulose-lignin-composite-hydrogel-as-a-promising-agent-in-chronic-wound-healing
#7
Danica Zmejkoski, Dragica Spasojević, Irina Orlovska, Natalia Kozyrovska, Marina Soković, Jasmina Glamočlija, Svetlana Dmitrović, Branko Matović, Nikola Tasić, Vuk Maksimović, Mikhail Sosnin, Ksenija Radotić
Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones...
June 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29907971/loss-of-specificity-variants-of-wzxc-suggest-that-substrate-recognition-is-coupled-with-transporter-opening-in-mop-family-flippases
#8
Lok To Sham, Sanduo Zheng, Anastasiya A Yakhnina, Andrew C Kruse, Thomas G Bernhardt
Bacteria produce a variety of surface-exposed polysaccharides important for cell integrity, biofilm formation, and evasion of the host immune response. Synthesis of these polymers often involves the assembly of monomer oligosaccharide units on the lipid carrier undecaprenyl-phosphate at the inner face of the cytoplasmic membrane. For many polymers, including cell wall peptidoglycan, the lipid-linked precursors must be transported across the membrane by flippases to facilitate polymerization at the membrane surface...
June 15, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29906773/in-vitro-investigation-of-anti-acne-properties-of-mangifera-indica-l-kernel-extract-and-its-mechanism-of-action-against-propionibacterium-acnes
#9
Worrapan Poomanee, Wantida Chaiyana, Monika Mueller, Helmut Viernstein, Watcharee Khunkitti, Pimporn Leelapornpisid
Propionibacterium acnes has been recognized as a main target for medical treatment of acne since this bacterium promotes acne inflammation by inducing upregulation of pro-inflammatory cytokines production, resulting in an accumulation of neutrophils and oxygen-free radicals produced by neutrophils within acne lesion. The aims of this study were to evaluate the biological activities of Mangifera indica kernel extracts grown in Northern Thailand (Kaew-Moragot cultivar), related to anti-acne properties including antimicrobial effect against acne-inducing bacteria together with the first elucidation of the mechanism of action against Propionibacterium acnes, anti-oxidation, and anti-inflammation...
May 17, 2018: Anaerobe
https://www.readbyqxmd.com/read/29906721/does-the-biological-treatment-or-membrane-separation-reduce-the-antibiotic-resistance-genes-from-swine-wastewater-through-a-sequencing-batch-membrane-bioreactor-treatment-process
#10
Qianwen Sui, Chao Jiang, Junya Zhang, Dawei Yu, Meixue Chen, Yawei Wang, Yuansong Wei
Swine wastes are the reservoir of antibiotic resistance genes (ARGs), which can potentially spread from swine farms to the environment. This study establishes a sequencing-batch membrane bioreactor (SMBR) for ARG removal from swine wastewater, and analyzes the effect of biological treatment and membrane separation on the ARG removal at different solid retention times (SRTs). The SMBR removed 2.91 logs (copy number) of ARGs at a short SRT (12 days). Raising the SRT reduced the removal rates of the detected genes by the biological treatment...
June 12, 2018: Environment International
https://www.readbyqxmd.com/read/29906686/lipidated-%C3%AE-%C3%AE-aa-heterogeneous-peptides-as-antimicrobial-agents
#11
Sylvia Singh, Alekhya Nimmagadda, Ma Su, Minghui Wang, Peng Teng, Jianfeng Cai
With an increase of resistance in bacteria there is an urgent need for alternative treatment methods that could complement conventional antibiotics. In the past two decades, focus has been drawn to Host Defense Peptides (HDPs) as potential antibiotic agents. Herein we reported our studies on the development of lipidated α/α-AA heterogeneous peptides as a new class of HDP mimetics. These compounds showed potent antimicrobial activity toward both Gram-positive and Gram-negative bacteria, and they also displayed excellent selectivity as they only exhibited limited hemolytic activity...
June 5, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29906103/cell-based-green-fluorescent-biosensor-using-cytotoxic-pathway-for-bacterial-lipopolysaccharide-recognition
#12
Jiadi Sun, Pei Zhu, Xiumei Wang, Jian Ji, Jean de Dieu Habimana, Jingdong Shao, Hongtao Lei, Yinzhi Zhang, Xiulan Sun
Lipopolysaccharide (LPS), a characteristic component of the outer membrane of Gram-negative bacteria, can be used as an effective biomarker to detect bacterial contamination. Here, we reported a 293/hTLR4A-MD2-CD14 cell-based fluorescent biosensor to detect and identify LPS, which is carried out in a 96-well microplate with nondestructive, user-friendly and high efficiency. The promoter sequence of the critical signaling pathway gene ZC3H12A (encoding MCPIP1 protein) and Enhanced Green Fluorescence Protein (EGFP) were combined to construct a recombinant plasmid, which was transferred into 293/hTLR4A-MD2-CD14 cells through lipid-mediated, DNA-transfection way...
June 15, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29905903/action-mechanism-of-melittin-derived-antimicrobial-peptides-mdp1-and-mdp2-de-novo-designed-against-multidrug-resistant-bacteria
#13
Reza Akbari, Mojdeh Hakemi Vala, Ali Hashemi, Hossein Aghazadeh, Jean-Marc Sabatier, Kamran Pooshang Bagheri
The emergence and dissemination of multidrug resistant (MDR) bacteria are major challenges for antimicrobial chemotherapy of bacterial infections. In this critical condition, cationic antimicrobial peptides are 'novel' promising candidate antibiotics to overcome the issue. In this study, we investigated the antibacterial mechanism of new melittin-derived peptides (i.e., MDP1 and MDP2) against multidrug resistant Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. MDP1 was designed with deletion of three amino acid residues, i...
June 15, 2018: Amino Acids
https://www.readbyqxmd.com/read/29904084/signature-of-pareto-optimization-in-the-escherichia-coli-proteome
#14
Loren Koçillari, Piero Fariselli, Antonio Trovato, Flavio Seno, Amos Maritan
Proteins have coevolved with cellular environments to improve or preserve their functions, maintaining at the same time the degree of hydrophobicity necessary to fold correctly and enough solubility to perform their biological roles. Here, we study the Escherichia coli proteome using a Pareto front analysis in the solubility-hydrophobicity space. The results indicate the existence of a Pareto optimal front, a triangle whose vertices correspond to archetypal proteins specialized in distinct tasks, such as regulatory processes, membrane transport, outer-membrane pore formation, catalysis, and binding...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902442/the-listeriolysin-o-pest-like-sequence-co-opts-ap-2-mediated-endocytosis-to-prevent-plasma-membrane-damage-during-listeria-infection
#15
Chen Chen, Brittney N Nguyen, Gabriel Mitchell, Shally R Margolis, Darren Ma, Daniel A Portnoy
Listeriolysin O (LLO) is a cholesterol-dependent cytolysin that mediates escape of Listeria monocytogenes from a phagosome, enabling growth of the bacteria in the host cell cytosol. LLO contains a PEST-like sequence that prevents it from killing infected cells, but the mechanism involved is unknown. We found that the LLO PEST-like sequence was necessary to mediate removal of LLO from the interior face of the plasma membrane, where it coalesces into discrete puncta. LLO interacts with Ap2a2, an adaptor protein involved in endocytosis, via its PEST-like sequence, and Ap2a2-dependent endocytosis is required to prevent LLO-induced cytotoxicity...
June 13, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29901262/spreading-the-news-about-the-novel-conjugation-mechanism-in-streptomyces-bacteria
#16
Gregg S Pettis
The hallmark of mycelial spore-forming bacteria of the genus Streptomyces is their prolific production of antibiotics and other bioactive secondary metabolites as part of a complex morphological and physiological developmental program. They are further distinguished by a conjugation mechanism that differs substantially from the single-strand mode of DNA transfer via Type IV secretion, which is exhibited by numerous unicellular Gram-negative and Gram-positive bacteria. At the crux of the novel intermycelial transfer event in Streptomyces spp...
June 14, 2018: Environmental Microbiology Reports
https://www.readbyqxmd.com/read/29901256/arbuscular-mycorrhizal-fungi-stimulate-organic-phosphate-mobilization-associated-with-changing-bacterial-community-structure-under-field-conditions
#17
Lin Zhang, Ning Shi, Jiequn Fan, Fei Wang, Timothy S George, Gu Feng
The extraradical hyphae of arbuscular mycorrhizal fungi (AMF) harbor and interact with a microbial community performing multiple functions. However, how the AMF-microbiome interaction influences the phosphorus (P) acquisition efficiency of the mycorrhizal pathway is unclear. Here we investigated whether AMF and their hyphal microbiome play a role in promoting organic phosphorus (P) mineralizing under field conditions. We developed an AMF hyphae in-growth core system for the field by using PVC tubes sealed with membrane with different size of pores (30 or 0...
June 14, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29900637/human-apolipoprotein-e-as-a-reservoir-of-cryptic-bioactive-peptides-the-case-of-apoe-133-167
#18
Anna Zanfardino, Andrea Bosso, Giovanni Gallo, Valeria Pistorio, Michela Di Napoli, Rosa Gaglione, Eliana Dell'Olmo, Mario Varcamonti, Eugenio Notomista, Angela Arciello, Elio Pizzo
Bioactive peptides derived from the receptor-binding region of human apolipoprotein E have previously been reported. All these peptides, encompassing fragments of this region or designed on the basis of short repeated cationic sequences identified in the same region, show toxic activities against a broad spectrum of bacteria and interesting immunomodulatory effects. However, the ability of these molecules to exert antibiofilm properties has not been described so far. In the present work, we report the characterization of a novel peptide, corresponding to residues 133 to 167 of human apolipoprotein E, here named ApoE (133-167)...
June 14, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29900600/multivalent-interactions-between-2d-nanomaterials-and-biointerfaces
#19
REVIEW
Zhaoxu Tu, Guy Guday, Mohsen Adeli, Rainer Haag
2D nanomaterials, particularly graphene, offer many fascinating physicochemical properties that have generated exciting visions of future biological applications. In order to capitalize on the potential of 2D nanomaterials in this field, a full understanding of their interactions with biointerfaces is crucial. The uptake pathways, toxicity, long-term fate of 2D nanomaterials in biological systems, and their interactions with the living systems are fundamental questions that must be understood. Here, the latest progress is summarized, with a focus on pathogen, mammalian cell, and tissue interactions...
June 14, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29899345/subtractive-proteomics-to-identify-novel-drug-targets-and-reverse-vaccinology-for-the-development-of-chimeric-vaccine-against-acinetobacter-baumannii
#20
Vandana Solanki, Vishvanath Tiwari
The emergence of drug-resistant Acinetobacter baumannii is the global health problem associated with high mortality and morbidity. Therefore it is high time to find a suitable therapeutics for this pathogen. In the present study, subtractive proteomics along with reverse vaccinology approaches were used to predict suitable therapeutics against A. baumannii. Using subtractive proteomics, we have identified promiscuous antigenic membrane proteins that contain the virulence factors, resistance factors and essentiality factor for this pathogenic bacteria...
June 13, 2018: Scientific Reports
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