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Gad 2 obesity

Jai Prakash, Balraj Mittal, Shally Awasthi, Neena Srivastava
BACKGROUND: Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene -243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes. METHODS: Insulin, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method...
April 2016: Iranian Journal of Public Health
T Hofmann, U Elbelt, A Ahnis, A Obbarius, M Rose, B F Klapp, A Stengel
Irisin has recently been proposed to act as a myokine secreted from skeletal muscle following exercise and to exert several health-beneficial effects, although its role is far from being established. In contrast to the growing body of literature on the biological regulation and function of irisin, there is no evidence on potential associations with mental functions. Since physical activity has been reported to have favorable impact on mental functions, we investigated the association of irisin with depressiveness, perceived stress, and anxiety as well as eating disorder symptoms in obese women...
April 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
Stephanie E Cassin, Sanjeev Sockalingam, Chau Du, Susan Wnuk, Raed Hawa, Sagar V Parikh
BACKGROUND: Psychosocial interventions can improve eating behaviours and psychosocial functioning in bariatric surgery candidates. However, those that involve face-to-face sessions are problematic for individuals with severe obesity due to mobility issues and practical barriers. OBJECTIVE: To examine the efficacy of a pre-operative telephone-based cognitive behavioural therapy (Tele-CBT) intervention versus standard pre-operative care for improving eating psychopathology and psychosocial functioning...
May 2016: Behaviour Research and Therapy
Gouda K Helal, Magdy A Gad, Mohamed F Abd-Ellah, Elsayed M Mahgoup
BACKGROUND: Ezetimibe has been reported to inhibit viral entry and to reduce BMI and has been proposed as a novel therapeutic agent for chronic hepatitis C (CHC), potentiating the effects of pegylated interferon and ribavirin (peg-IFN/RBV). OBJECTIVE: The aim of the study was to assess the effects of ezetimibe coadministration with peg-IFN/RBV combination on the early virological response (EVR) rates in nonobese and obese patients with CHC genotype 4 (CHC-4). PATIENTS AND METHODS: A total of 144 CHC-4 patients were divided into two groups; group 1 included nonobese patients (n=76) and group 2 included obese patients (n=68)...
May 2016: European Journal of Gastroenterology & Hepatology
Andrea Figura, Anne Ahnis, Andreas Stengel, Tobias Hofmann, Ulf Elbelt, Jürgen Ordemann, Matthias Rose
BACKGROUND: The amount of excess weight loss (%EWL) among obese patients after bariatric surgery varies greatly. However, reliable predictors have not been established yet. The present study evaluated the preoperative psychological burden, coping style, and motivation to lose weight as factors determining postoperative treatment success. METHODS: The sample included 64 morbidly obese patients with a preoperative BMI of 51 ± 8 kg/m(2) who had undergone laparoscopic sleeve gastrectomy (LSG)...
2015: Journal of Obesity
Michal Laufer Perl, Ofer Havakuk, Ariel Finkelstein, Amir Halkin, Miri Revivo, Meital Elbaz, Itzhak Herz, Gad Keren, Shmuel Banai, Yaron Arbel
OBJECTIVES: High values of Red Blood Cell Distribution Width (RDW) have been associated with adverse outcome in various clinical settings. The mechanism behind this association is not clear. The Metabolic Syndrome (MetS) is a chronic inflammatory disorder that increases the risk for cardiovascular disease and death. The aim of our study was to evaluate the association between high RDW and the MetS in a relatively large cohort of patients. METHODS: A cohort of 3,529 consecutive patients undergoing coronary angiography was used to evaluate the association between RDW and the MetS...
September 25, 2015: Clinical Hemorheology and Microcirculation
Tobias Hofmann, Anne Ahnis, Ulf Elbelt, Matthias Rose, Burghard F Klapp, Andreas Stengel
OBJECTIVE: NUCB2/nesfatin-1 is an anorexigenic hormone with elevated levels in obese and decreased levels in anorexia nervosa (AN) patients. Moreover, a role in the regulation of stress and emotions was suggested by several rodent and preliminary human studies. Since anxiety and depression are common comorbidities in AN, we investigated the association of NUCB2/nesfatin-1 with anxiety, depression and perceived stress in AN. METHODS: We analyzed circulating NUCB2/nesfatin-1 levels in 64 female inpatients diagnosed with anorexia nervosa (body mass index, BMI; mean±SD, 14...
2015: PloS One
Tobias Hofmann, Ulf Elbelt, Anne Ahnis, Matthias Rose, Burghard F Klapp, Andreas Stengel
Nesfatin-1 is cleaved from nucleobindin2 (NUCB2) and implicated in the regulation of hunger and satiety as anorexigenic peptide hormone. Circulating NUCB2/nesfatin-1 is elevated in obesity and decreased in anorexia nervosa. In addition, a role in the regulation of stress, anxiety and depression has been demonstrated. First evidence suggested that NUCB2/nesfatin-1 might be regulated in a sex-specific manner. Thus, we investigated NUCB2/nesfatin-1 plasma levels in association with perceived stress, anxiety and depressiveness in obese men and women...
October 2015: Psychoneuroendocrinology
Dale S Bond, Dawn C Buse, Richard B Lipton, J Graham Thomas, Lucille Rathier, Julie Roth, Jelena M Pavlovic, E Whitney Evans, Rena R Wing
OBJECTIVE/BACKGROUND: Obesity is related to migraine. Maladaptive pain coping strategies (eg, pain catastrophizing) may provide insight into this relationship. In women with migraine and obesity, we cross-sectionally assessed: (1) prevalence of clinical catastrophizing; (2) characteristics of those with and without clinical catastrophizing; and (3) associations of catastrophizing with headache features. METHODS: Obese women migraineurs seeking weight loss treatment (n = 105) recorded daily migraine activity for 1 month via smartphone and completed the Pain Catastrophizing Scale (PCS)...
July 2015: Headache
Ohad Guetta, Amnon Ovnat, Gad Shaked, David Czeiger, Gilbert Sebbag
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) became a prevalent bariatric procedure in Israel, while laparoscopic adjustable gastric banding (LAGB) was losing ground, due to high failure rates (40 % at 10 years). Many patients after LAGB failure choose LSG as a further bariatric surgery (secondary LSG). However, LAGB often impairs upper stomach anatomy and physiology, which may contribute to complications increased risk after secondary LSG, in comparison to surgery-naive obese patients choosing LSG (primary LSG)...
November 2015: Obesity Surgery
Matthias Michal, Jürgen H Prochaska, Karsten Keller, Sebastian Göbel, Meike Coldewey, Alexander Ullmann, Andreas Schulz, Heidrun Lamparter, Thomas Münzel, Iris Reiner, Manfred E Beutel, Philipp S Wild
BACKGROUND/OBJECTIVES: Depression and anxiety are highly prevalent in cardiovascular patients. Therefore, we examined whether the 4-item Patient Health Questionnaire (PHQ-4, measuring symptoms of depression and anxiety) predicts all-cause mortality in outpatients with long-term oral anticoagulation (OAC). METHODS: The sample comprised n=1384 outpatients from a regular medical care setting receiving long-term OAC with vitamin K antagonists. At baseline, symptoms of anxiety and depression were assessed with the PHQ-4 and the past medical history was taken...
2015: International Journal of Cardiology
Maayan Konigstein, Ofer Havakuk, Yaron Arbel, Ariel Finkelstein, Eyal Ben-Assa, Eran Leshem Rubinow, Yigal Abramowitz, Gad Keren, Shmuel Banai
BACKGROUND: Obesity is a major risk factor for cardiovascular morbidity and mortality. A considerable number of studies, however, showed better outcomes for overweight patients undergoing cardiovascular interventions-the so called obesity paradox. HYPOTHESIS: Increased body mass index (BMI) is independently associated with improved survival following transcatheter aortic valve implantation (TAVI). METHODS: We analyzed the data of 409 consecutive patients undergoing TAVI in our medical center...
February 2015: Clinical Cardiology
Raffaella Buzzetti, Marialuisa Spoletini, Simona Zampetti, Giuseppe Campagna, Lidia Marandola, Francesca Panimolle, Francesco Dotta, Claudio Tiberti
OBJECTIVE: Since patients with type 2 diabetes and positive for type 1 diabetes-specific antibodies have wide variations in BMI, this study evaluated whether the frequency and pattern of islet autoantibody positivity is related to BMI. RESEARCH DESIGN AND METHODS: Clinical and biochemical characteristics and islet autoantibodies including GAD and protein tyrosine phosphatases islet antigen-2 (IA-2)IC and IA-2(256-760) were evaluated in 1,850 patients with type 2 diabetes from the Non-Insulin Requiring Autoimmune Diabetes study cohort...
March 2015: Diabetes Care
Rengasamy Palanivel, Riya Ganguly, Subat Turdi, Aimin Xu, Gary Sweeney
OBJECTIVE: Adiponectin is known to confer its cardioprotective effects in obesity and type 2 diabetes, mainly by regulating glucose and fatty acid metabolism in cardiomyocytes. Dynamic actin cytoskeleton remodeling is involved in regulation of multiple biological functions, including glucose uptake. Here we investigated in neonatal cardiomyocytes whether adiponectin induced actin cytoskeleton remodeling and if this played a role in adiponectin-stimulated glucose uptake. MATERIALS/METHODS: Primary cardiomyocytes were treated with full-length and globular adiponectin (fAd and gAd, respectively)...
October 2014: Metabolism: Clinical and Experimental
Walid Saliba, Ofra Barnett-Griness, Gad Rennert
Sequestration of vitamin D in adipose tissue is the main cause of the lower serum 25(OH)D levels in obese subjects. However, it remains unknown whether the adipose tissue stores of vitamin D are readily mobilized for meeting body needs. We aimed to examine whether the association between serum 25(OH)D and all-cause mortality differs by body weight. Using the computerized database of the largest health care provider in Israel, we identified a cohort of subjects ≥20-years old with serum 25(OH)D levels measured between January 2008 and December 2009...
September 2014: Calcified Tissue International
Shervin Assari
BACKGROUND: Most studies on mental health associates of obesity have focused on depression and less is known about the role of anxiety in obesity. OBJECTIVES: This study compared the additive effects of General Anxiety Disorder (GAD) and Major Depressive Disorder (MDD) on Body Mass Index (BMI) across sub-populations of Blacks based on the intersection of ethnicity and gender. METHODS: Data came from the National Survey of American Life (NSAL), 2001 - 2003...
April 2014: International Cardiovascular Research Journal
Arash Azin, Carrol Zhou, Timothy Jackson, Stephanie Cassin, Sanjeev Sockalingam, Raed Hawa
BACKGROUND: Body-contouring surgery can be a solution to excess skin folds following bariatric surgery. Many patients desire body-contouring surgery, but the cost of the procedure may be a limiting factor. This study aims to examine barriers to access and to compare socioeconomic variables and psychological variables between bariatric surgery patients who have undergone body contouring and those who have not. METHODS: In this cross-sectional study, a questionnaire packet was administered to (1) patients who underwent bariatric but not body-contouring surgery and (2) patients who underwent both...
June 2014: Plastic and Reconstructive Surgery
Jeanette M Jerrell, Roger S McIntyre, Yong-Moon Mark Park
The greater burden of illness in youth with co-occurring attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder (MDD) deserves further investigation, specifically regarding the influence of other psychiatric or medical conditions and the pharmacotherapies prescribed. A retrospective cohort design was employed, using South Carolina's (USA) Medicaid claims' dataset covering outpatient and inpatient medical services, and medication prescriptions between January, 1996 and December, 2006 for patients ≤17 years of age...
January 2015: European Child & Adolescent Psychiatry
Claudia Gragnoli
Proteasome modulator 9 (PSMD9) gene single nucleotide polymorphism (SNP) rs1043307/rs2514259 (E197G) is associated with significant clinical response to the anti-depressant desipramine. PSMD9 SNP rs74421874 [intervening sequence (IVS) 3 + nt460 G>A], rs3825172 (IVS3 + nt437 C>T) and rs1043307/rs2514259 (E197G A>G) are all linked to type 2 diabetes (T2D), maturity-onset-diabetes-of the young 3 (MODY3), obesity and waist circumference, hypertension, hypercholesterolemia, T2D-macrovascular and T2D-microvascular disease, T2D-neuropathy, T2D-carpal tunnel syndrome, T2D-nephropathy, T2D-retinopathy, non-diabetic retinopathy and depression...
September 2014: Journal of Cellular Physiology
Dan Carter, Marc Beer-Gabel, Dorit Tzur, Gad Levy, Estela Derazne, Ben Novis, Arnon Afek
BACKGROUND: The prevalence of irritable bowel syndrome (IBS) in the community has been reported in numerous cross-sectional surveys. However, little is known about the incidence and predictive factors for the clinical diagnosis of IBS. METHODS: We examined the association of socioeconomic, anthropometric, and occupational factors with the incidence of IBS in a cohort of 440,822 young Israeli adults aged 18 to 39 who served in active military service during the years 2005 to 2011...
April 2015: Journal of Clinical Gastroenterology
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