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https://www.readbyqxmd.com/read/29031197/mitochondrial-dysfunction-is-responsible-for-fatty-acid-synthase-inhibition-induced-apoptosis-in-breast-cancer-cells-by-pdpamn
#1
Qiang Wang, Xia Du, Bingjie Zhou, Jing Li, Wenlong Lu, Qiuyun Chen, Jing Gao
Targeting cellular metabolism is becoming a hallmark to overcome drug resistance in breast cancer treatment. Activation of fatty acid synthase (FASN) has been shown to promote breast cancer cell growth. However, there is no concrete report underlying the mechanism associated with mitochondrial dysfunction in relation to fatty acid synthase inhibition-induced apoptosis in breast cancer cells. The current study is aimed at exploring the effect of the novel manganese (Mn) complex, labeled as PdpaMn, on lipid metabolism and mitochondrial function in breast cancer cells...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29027229/extracellular-nucleosides-and-nucleotides-as-immunomodulators
#2
REVIEW
Oliver Kepp, Friedemann Loos, Peng Liu, Guido Kroemer
Some anticancer agents induce immunogenic cell death that is accompanied by the emission of danger signals into the tumor microenvironment, thus attracting and activating innate immune effectors and finally inducing anticancer immunity. The release of extracellular nucleosides such as adenosine triphosphate (ATP) from the tumor in response to anticancer therapy plays a pivotal role in the attraction of antigen presenting cells and the activation of inflammasome-mediated proinflammatory cascades. In contrast, the ectonucleotidase-catalyzed phosphohydrolysis of nucleotides to nucleosides reduces the extracellular availability of nucleotides, hence limiting the recruitment and activation of antigen-presenting cells...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29024930/effect-of-concurrent-src-kinase-inhibition-with-short-duration-hypothermia-on-ca2-calmodulin-kinase-iv-activity-and-neuropathology-after-hypoxia-ischemia-in-the-newborn-swine-brain
#3
Panagiotis Kratimenos, Ioannis Koutroulis, Amit Jain, Shadi Malaeb, Maria Delivoria-Papadopoulos
BACKGROUND: Hypoxia-ischemia (HI) results in increased activation of Ca2+/calmodulin kinase IV (CaM kinase IV) mediated by Src kinase. Therapeutic hypothermia ameliorates neuronal injury in the newborn. HYPOTHESIS: Inhibition of Src kinase concurrently with hypothermia further attenuates the hypoxia-induced increased activation of CaM kinase IV compared with hypothermia alone. DESIGN/METHODS: Ventilated piglets were exposed to HI, received saline or a selective Src kinase inhibitor (PP2), and were cooled to 33°C...
October 13, 2017: Neonatology
https://www.readbyqxmd.com/read/29022483/in-vitro-combined-effect-of-doxorubicin-and-sulfonated-zinc-phthalocyanine-mediated-photodynamic-therapy-on-mcf-7-breast-cancer-cells
#4
Eric Chekwube Aniogo, Blassan Plackal Adimuriyil George, Heidi Abrahamse
Doxorubicin is a broad-spectrum antibiotic and anticancer drug used to treat a variety of human malignancies like breast cancer and leukaemia. Unfortunately, a dose-dependent side effect of this drug is common, representing a major obstacle to its use despite its therapeutic efficacy. Photodynamic therapy is an emerging non-invasive potential adjuvant for conventional cancer treatment. In an attempt to circumvent the dose-limiting effect of doxorubicin, this study aimed to investigate cellular anticancer activity of doxorubicin and sulfonated zinc phthalocyanine-mediated photodynamic therapy on MCF-7 cells alone and in combination...
October 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/29021844/intracoronary-acetylcholine-application-as-a-possible-probe-inducing-j-waves-in-patients-with-early-repolarization-syndrome
#5
REVIEW
Toru Maruyama, Kazumasa Fujita, Kei Irie, Shouhei Moriyama, Mitsuhiro Fukata
Acetylcholine is widely used for a diagnostic provocation test of coronary spasm in patients with vasospastic angina. Acetylcholine usually induces coronary vasodilatation mediated by muscarinic receptor activation, but sometimes it evokes vasoconstriction of coronary arteries where the endothelium is damaged. Early repolarization syndrome is characterized by a J wave observed at the end of the QRS complex in a surface electrocardiogram. The J wave is attributed to the transmural voltage gradient at the early repolarization phase across the ventricular wall, which stems mainly from prominent transient outward current in the epicardium, but not in the endocardium...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29018353/heat-stress-reduces-sperm-motility-via-activation-of-glycogen-synthase-kinase-3%C3%AE-and-inhibition-of-mitochondrial-protein-import
#6
Yabin Gong, Huiduo Guo, Zhilong Zhang, Hao Zhou, Ruqian Zhao, Bin He
The adverse effects of high environmental temperature exposure on animal reproductive functions have been concerned for many decades. However, the molecular basis of heat stress (HS)-induced decrease of sperm motility has not been entirely elucidated. We hypothesized that the deteriorate effects of HS may be mediated by damage of mitochondrial function and ATP synthesis. To test this hypothesis, we use mature boar sperm as model to explore the impacts of HS on mitochondrial function and sperm motility. A 6 h exposure to 42°C (HS) induced significant decrease in sperm progressive motility...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29017492/electroacupuncture-ameliorating-post-stroke-cognitive-impairments-via-inhibition-of-peri-infarct-astroglial-and-microglial-macrophage-p2-purinoceptors-mediated-neuroinflammation-and-hyperplasia
#7
Jia Huang, Xiaofang You, Weilin Liu, Changming Song, Xiaomin Lin, Xiufeng Zhang, Jing Tao, Lidian Chen
BACKGROUND: During ischemic stroke (IS), adenosine 5'-triphosphate (ATP) is released from damaged nerve cells of the infract core region to the extracellular space, invoking peri-infarct glial cellular P2 purinoceptors singling, and causing pro-inflammatory cytokine secretion, which is likely to initiate or aggravate motor and cognitive impairment. It has been proved that electroacupuncture (EA) is an effective and safe strategy used in anti-inflammation. However, EA for the role of purine receptors in the central nervous system has not yet been reported...
October 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29017418/maternal-glucose-supplementation-in-a-murine-model-of-chorioamnionitis-alleviates-dysregulation-of-autophagy-in-fetal-brain
#8
Jun Lei, Wenyu Zhong, Ahmad Almalki, Hongxi Zhao, Hattan Arif, Rayyan Rozzah, Ghada Al Yousif, Nader Alhejaily, Dan Wu, Michael McLane, Irina Burd
Fetal brain injury induced by intrauterine inflammation is a major risk factor for adverse neurological outcomes, including cerebral palsy, cognitive dysfunction, and behavioral disabilities. There are no adequate therapies for neuronal protection to reduce fetal brain injury, especially new strategies that may apply promptly and conveniently. In this study, we explored the effect of maternal glucose administration in a mouse model of intrauterine inflammation at term. Our results demonstrated that maternal glucose supplementation significantly increased survival birth rate and improved the neurobehavioral performance of pups exposed to intrauterine inflammation...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28993020/corrigendum-to-crystal-structure-of-human-transglutaminase-2-in-complex-with-adenosine-triphosphate-int-j-biol-macromol-47-2010-190-195
#9
Byeong-Gu Han, Jea-Won Cho, Young Doo Cho, Kyung-Chae Jeong, Soo-Youl Kim, Byung Il Lee
No abstract text is available yet for this article.
October 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28992079/sustained-activation-of-p2x7-induces-mmp-2-evoked-cleavage-and-functional-purinoceptor-inhibition
#10
Christopher N J Young, Natalia Chira, Justyna Róg, Rasha Al-Khalidi, Magalie Benard, Ludovic Galas, Philippe Chan, David Vaudry, Krzysztof Zablocki, Dariusz C Górecki
P2X7 purinoceptor promotes survival or cytotoxicity depending on extracellular adenosine triphosphate (ATP) stimulus intensity controlling its ion channel or P2X7-dependent large pore (LP) functions. Mechanisms governing this operational divergence and functional idiosyncrasy are ill-understood. We have discovered a feedback loop where sustained activation of P2X7 triggers release of active matrix metalloproteinase 2 (MMP-2), which halts ion channel and LP responses via the MMP-2-dependent receptor cleavage...
August 18, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28987709/impact-of-levosimendan-on-platelet-function
#11
Joanna Sikora, Krzysztof Pstrągowski, Natalia Skibińska, Przemysław Sobczak, Adam Sikora, Michał Piotr Marszałł, Tomasz Fabiszak, Grzegorz Grześk, Jacek Kubica
Levosimendan has been developed for treatment of severe heart failure. The favorable hemodynamic effect of levosimendan is related to its unique dual mechanism of action - increase of the contractile force of the myocardium caused by enhanced sensitivity of myofilaments to calcium combined with vasodilatation caused by the opening of adenosine triphosphate - dependent potassium channels. Due to the structural similarities to phosphodiesterase inhibitors it may partly exert its action via inhibition of phosphodiesterase inhibitors III...
October 2, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28986142/limonene-protects-osteoblasts-against-methylglyoxal-derived-adduct-formation-by-regulating-glyoxalase-oxidative-stress-and-mitochondrial-function
#12
Kwang Sik Suh, Suk Chon, Eun Mi Choi
Methylglyoxal (MG) is a potent protein glycating agent and an important precursor of advanced glycation end products, which are involved in the pathogenesis of diabetic osteopathy. In this study, we investigated the effects of limonene on MG-induced damage in osteoblastic MC3T3-E1 cells. Pretreating cells with limonene prevented MG-induced protein adduct formation, tumor necrosis factor alpha and interleukin-6 release, mitochondrial superoxide production, and cardiolipin peroxidation. In addition, limonene increased glyoxalase I activity, and glutathione and heme oxygenase-1 levels in the presence of MG...
October 3, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28983542/a-versatile-covalent-organic-framework-based-platform-for-sensing-biomolecules
#13
Wei Li, Cheng-Xiong Yang, Xiu-Ping Yan
We herein report the design of a versatile covalent organic framework (COF)-based platform for sensing biomolecules. As a proof of concept, a highly sensitive and selective COF-based fluorescence turn-on detection of DNA and adenosine 5'-triphosphate is demonstrated.
October 6, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28977611/peptide-based-regulation-of-metabolism-as-related-to-obesity
#14
Werner G Bergen
Currently there are few, if any, approved and effective medicines for the attenuation of obesity, diabetes, and insulin resistance. This commentary addresses a communication describing the effect on glucose dynamics and obesity of a peptide monoclonal antibody for fibroblast growth factor (FGF) receptor 1c isoform (FGFR1c). The general lack of suitable, effective drugs is discussed, as is the treatment potential of FGF family receptors. The FGFR1c monoclonal antibody developed by the authors lowers body weight gain, blood glucose, and adipose tissue weight...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28977595/glucose-sensitive-cftr-suppresses-glucagon-secretion-by-potentiating-katp-channels-in-pancreatic-islet-%C3%AE-cells
#15
Wen Qing Huang, Jing Hui Guo, Xiao Hu Zhang, Mei Kuen Yu, Yiu Wa Chung, Ye Chun Ruan, Hsiao Chang Chan
The secretion of glucagon by islet α cells is normally suppressed by high blood glucose, but this suppressibility is impaired in patients with diabetes or cystic fibrosis (CF), a disease caused by mutations in the gene encoding CF transmembrane conductance regulator (CFTR), a cyclic adenosine monophosphate-activated Cl- channel. However, precisely how glucose regulates glucagon release remains controversial. Here we report that elevated glucagon secretion, together with increased glucose-induced membrane depolarization and Ca2+ response, is found in CFTR mutant (DF508) mice/islets compared with the wild-type...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28977592/cftr-influences-beta-cell-function-and-insulin-secretion-through-non-cell-autonomous-exocrine-derived-factors
#16
Xingshen Sun, Yaling Yi, Weiliang Xie, Bo Liang, Michael C Winter, Nan He, Xiaoming Liu, Meihui Luo, Yu Yang, Katie Larson Ode, Aliye Uc, Andrew W Norris, John F Engelhardt
Although β-cell dysfunction in cystic fibrosis (CF) leads to diabetes, the mechanism by which the cystic fibrosis transmembrane conductance regulator (CFTR) channel influences islet insulin secretion remains debated. We investigated the CFTR-dependent islet-autonomous mechanisms affecting insulin secretion by using islets isolated from CFTR knockout ferrets. Total insulin content was lower in CF as compared with wild-type (WT) islets. Furthermore, glucose-stimulated insulin secretion (GSIS) was impaired in perifused neonatal CF islets, with reduced first, second, and amplifying phase secretion...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28976496/development-of-contractile-properties-in-the-fetal-porcine-urinary-bladder
#17
Lotte K Jakobsen, Karina F Trelborg, Ulf Simonsen, Karl-Erik Andersson, L H Olsen
BackgroundIn early fetal life, the bladder is merely a conduit allowing urine to pass through freely into the amniotic cavity. As the striated external urethral sphincter evolves, the bladder acquires its reservoir and voiding functions. We characterized the myogenic and neurogenic contractions of the normal fetal porcine bladder from midterm until close to full-term gestation.MethodsContractile responses were measured in vitro using bladder strips from fetuses at 60 (N=23) and 100 days (N=21) of gestation...
October 4, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28975969/research-on-biogenesis-of-mitochondria-in-astrocytes-in-sepsis-associated-encephalopathy-models
#18
Y-Z Zhao, Z-Y Gao, L-Q Ma, Y-Y Zhuang, F-L Guan
OBJECTIVE: To study the structural and functional changes in mitochondria in astrocytes of the cerebral cortex of the rats in the simulated sepsis environment in vitro and the relationship between these changes and the biogenesis of mitochondria in astrocytes by establishing models of sepsis astrocytes. MATERIALS AND METHODS: The structural and functional changes in mitochondria in astrocytes of the cerebral cortex of the rats were evaluated. The ultra structural changes in the mitochondria, astrocytes, and ultrathin sections, were observed with a transmission electron microscope...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28973906/kinesin-rotates-unidirectionally-and-generates-torque-while-walking-on-microtubules
#19
Avin Ramaiya, Basudev Roy, Michael Bugiel, Erik Schäffer
Cytoskeletal motors drive many essential cellular processes. For example, kinesin-1 transports cargo in a step-wise manner along microtubules. To resolve rotations during stepping, we used optical tweezers combined with an optical microprotractor and torsion balance using highly birefringent microspheres to directly and simultaneously measure the translocation, rotation, force, and torque generated by individual kinesin-1 motors. While, at low adenosine 5'-triphosphate (ATP) concentrations, motors did not generate torque, we found that motors translocating along microtubules at saturating ATP concentrations rotated unidirectionally, producing significant torque on the probes...
September 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28966635/modulation-of-valosin-containing-protein-by-kyoto-university-substances-kus-as-a-novel-therapeutic-strategy-for-ischemic-neuronal-diseases
#20
REVIEW
Masayuki Hata, Hanako Ohashi Ikeda
Retinal ischemia causes several vision-threatening diseases, including diabetic retinopathy, retinal artery occlusion, and retinal vein occlusion. Intracellular adenosine triphosphate (ATP) depletion and subsequent induced endoplasmic reticulum (ER) stress are proposed to be the underlying mechanisms of ischemic retinal cell death. Recently, we found that a naphthalene derivative can inhibit ATPase activity of valosin-containing protein, universally expressed within various types of cells, including retinal neural cells, with strong cytoprotective activity...
August 2017: Neural Regeneration Research
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