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https://www.readbyqxmd.com/read/28339090/inhibition-of-farnesyl-pyrophosphate-synthase-attenuates-high-glucose%C3%A2-induced-vascular-smooth-muscle-cells-proliferation
#1
Guo-Ping Chen, Xiao-Qin Zhang, Tao Wu, Jie Han, Dan Ye
The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis accelerated by hyperglycemia. Our previous studies found that farnesyl pyrophosphate synthase (FPPS, EC 2.5.1.10), an essential enzyme in the mevalonate pathway, was upregulated in aorta media from diabetic mice along with the process of atherosclerosis. However, the exact role of FPPS in high glucose‑induced proliferation of VSMCs is largely unclear. In our study, we found that alendronate (an FPPS inhibitor) attenuated diabetic accelerated atherosclerosis in vivo and suppressed high glucose‑induced VSMCs proliferation in vitro...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28329789/mediterranean-diet-supplemented-with-coenzyme-q10-modulates-the-postprandial-metabolism-of-advanced-glycation-end-products-in-elderly-men-and-women
#2
Javier Lopez-Moreno, Gracia M Quintana-Navarro, Javier Delgado-Lista, Antonio Garcia-Rios, Juan F Alcala-Diaz, Francisco Gomez-Delgado, Antonio Camargo, Pablo Perez-Martinez, Francisco J Tinahones, Gary E Striker, Francisco Perez-Jimenez, Jose M Villalba, Jose Lopez-Miranda, Elena M Yubero-Serrano
Advanced glycation end products (AGEs) and oxidative stress are elevated with aging and dysmetabolic conditions. Because a Mediterranean (Med) diet reduces oxidative stress, serum AGEs levels, and gene expression related to AGEs metabolism in healthy elderly people, we studied whether supplementation with coenzyme Q10 (CoQ) was of further benefit. Twenty participants aged ≥ 65 (10 men and 10 women) were randomly assigned to each of three isocaloric diets for successive periods of 4 weeks in a crossover design: Med diet, Med + CoQ, and a Western high-saturated-fat diet (SFA diet)...
October 21, 2016: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28303649/transforming-sugars-into-fat-lipid-biosynthesis-using-different-sugars-in-yarrowia-lipolytica
#3
Piotr Hapeta, Magdalena Rakicka, Remi Dulermo, Heber Gamboa-Meléndez, Anne-Marie Cruz-Le Coq, Jean-Marc Nicaud, Zbigniew Lazar
In an era of ever-increasing energy demands, a promising technology is being developed: the use of oleaginous microorganisms such as Yarrowia lipolytica to convert waste materials into biofuels. Here, we constructed two Y. lipolytica strains that displayed both increased lipid accumulation and more efficient use of biomass-derived sugars, including glucose, fructose, galactose and inulin. The first strain, Y. lipolytica YLZ150, was derived from the French wild-type strain W29. It had inhibited triacylglycerol mobilization (∆tgl4) and β-oxidation (∆pox1-6), and it overexpressed GPD1, DGA2, HXK1, the native Leloir pathway, SUC2 from Saccharomyces cerevisiae and INU1 from Kluyveromyces marxianus...
March 17, 2017: Yeast
https://www.readbyqxmd.com/read/28272309/determination-of-the-clean-air-delivery-rate-cadr-of-photocatalytic-oxidation-pco-purifiers-for-indoor-air-pollutants-using-a-closed-loop-reactor-part-ii-experimental-results
#4
Valérie Héquet, Frédéric Batault, Cécile Raillard, Frédéric Thévenet, Laurence Le Coq, Éric Dumont
The performances of a laboratory PhotoCatalytic Oxidation (PCO) device were determined using a recirculation closed-loop pilot reactor. The closed-loop system was modeled by associating equations related to two ideal reactors: a perfectly mixed reservoir with a volume of VR = 0.42 m³ and a plug flow system corresponding to the PCO device with a volume of VP = 5.6 × 10(-3) m³. The PCO device was composed of a pleated photocatalytic filter (1100 cm²) and two 18-W UVA fluorescent tubes. The Clean Air Delivery Rate (CADR) of the apparatus was measured under different operating conditions...
March 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28173653/-coenzyme-q-10-treatment-for-one-child-with-coq6-gene-mutation-induced-nephrotic-syndrome-and-literature-review
#5
Q Cao, G M Li, H Xu, Q Shen, L Sun, X Y Fang, H M Liu, W Guo, Y H Zhai, B B Wu
Objective: To summarize the clinical manifestation and molecular characteristics of COQ6 mutation induced nephrotic syndrome, and to evaluate efficacy of CoQ(10) therapy. Method: Clinical data of the case with infantile nephrotic syndrome was summarized, including clinical manifestations, laboratory findings and family investigation. The patient received CoQ(10) 30 mg/(kg·d) therapy. Urine protein/creatinine ratio, serum albumin and creatinine were detected to assess the efficacy of the therapy. Result: (1) The 10 months old boy was presented with nephrotic level proteinuria and hypoalbuminemia...
February 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27503795/a-clock-network-for-geodesy-and-fundamental-science
#6
C Lisdat, G Grosche, N Quintin, C Shi, S M F Raupach, C Grebing, D Nicolodi, F Stefani, A Al-Masoudi, S Dörscher, S Häfner, J-L Robyr, N Chiodo, S Bilicki, E Bookjans, A Koczwara, S Koke, A Kuhl, F Wiotte, F Meynadier, E Camisard, M Abgrall, M Lours, T Legero, H Schnatz, U Sterr, H Denker, C Chardonnet, Y Le Coq, G Santarelli, A Amy-Klein, R Le Targat, J Lodewyck, O Lopez, P-E Pottie
Leveraging the unrivalled performance of optical clocks as key tools for geo-science, for astronomy and for fundamental physics beyond the standard model requires comparing the frequency of distant optical clocks faithfully. Here, we report on the comparison and agreement of two strontium optical clocks at an uncertainty of 5 × 10(-17) via a newly established phase-coherent frequency link connecting Paris and Braunschweig using 1,415 km of telecom fibre. The remote comparison is limited only by the instability and uncertainty of the strontium lattice clocks themselves, with negligible contributions from the optical frequency transfer...
2016: Nature Communications
https://www.readbyqxmd.com/read/27464616/impact-of-surgical-technique-on-long-term-complication-rate-after-laparoscopic-adjustable-gastric-banding-lagb-results-of-a-single-blinded-randomized-controlled-trial-anosean-study
#7
Benjamin Le Coq, Vincent Frering, Mohammed Ghunaim, Pierre Campan, André Dabrowski, Emmanuel Mulliez, Eric Loridan, Frédéric Combemale, Franck Denimal, Fanelly Torres, Gregory Baud, Camille Thibault, Guelareh Dezfoulian, Laurent Arnalsteen, Alain Duhamel, François Pattou, Robert Caiazzo
OBJECTIVE: The aim of the study was to explore the impact of the absence of band fixation on the reoperation rate and to identify other risk factors for long-term complications. BACKGROUND: Laparoscopic adjustable gastric banding has been demonstrated to permit important weight loss and comorbidity improvement, but some bands will have to be removed mainly for failure or in case of planned 2-step surgery. Then, the absence of a gastro-gastric suture (GGS) would allow easier band removal...
November 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27353847/resection-of-hepatocellular-carcinoma-in-elderly-patients-and-the-role-of-energy-balance
#8
Marco Cannistrà, Raffaele Grande, Michele Ruggiero, Matteo Novello, Alessandra Zullo, Elisabetta Bonaiuto, Sebastiano Vaccarisi, Giuseppe Cavallari, Raffaele Serra, Bruno Nardo
INTRODUCTION: Progressive functional impairment with age has a significant impact on perioperative risk management. Chronic liver diseases induce a strong oxidative stress; in the elderly, in particular, impaired elimination of free radicals leads to insufficient DNA repair. The events associated with a weak response to growth factors after hepatectomy leads to a decline in liver regeneration. Hypercholesterolemia is highly prevalent in the elderly, which may alter the coenzyme Q10 (CoQ) levels and in turn the cellular energy balance...
September 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27155576/disruption-of-the-human-coq5-containing-protein-complex-is-associated-with-diminished-coenzyme-q10-levels-under-two-different-conditions-of-mitochondrial-energy-deficiency
#9
Hsiu-Chuan Yen, Yi-Chun Liu, Chia-Chi Kan, Hsing-Ju Wei, Szu-Hsien Lee, Yau-Huei Wei, Yu-Hsiu Feng, Chih-Wei Chen, Chin-Chang Huang
BACKGROUND: The Coq protein complex assembled from several Coq proteins is critical for coenzyme Q6 (CoQ6) biosynthesis in yeast. Secondary CoQ10 deficiency is associated with mitochondrial DNA (mtDNA) mutations in patients. We previously demonstrated that carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP) suppressed CoQ10 levels and COQ5 protein maturation in human 143B cells. METHODS: This study explored the putative COQ protein complex in human cells through two-dimensional blue native-polyacrylamide gel electrophoresis and Western blotting to investigate its status in 143B cells after FCCP treatment and in cybrids harboring the mtDNA mutation that caused myoclonic epilepsy with ragged-red fibers (MERRF) syndrome...
September 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26833278/dna-damage-and-antioxidants-in-treatment-na%C3%A3-ve-children-with-obsessive-compulsive-disorder
#10
Şeref Şimşek, Salih Gençoğlan, Tuğba Yüksel
The current study aimed to investigate whether serum antioxidant levels and DNA damage differ between the children and adolescents with Obsessive Compulsive Disorder (OCD) and healthy controls. The study included 31 children (Male/Female, 22/9; age range 7-17 years), with treatment naïve OCD diagnosed according to Diagnostic and Statistical Manual of Mental Disorders-V (DSM-V) and 28 age- and gender-matched healthy control subjects. Children's Yale Brown Obsession Compulsion Scale (CY-BOC) was applied to the children...
March 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/26768296/determination-of-urinary-coenzyme-q10-by-hplc-with-electrochemical-detection-reference-values-for-a-paediatric-population
#11
Dèlia Yubero, Raquel Montero, Maria Ramos, Viruna Neergheen, Plácido Navas, Rafael Artuch, Iain Hargreaves
Kidney dysfunction is being increasingly associated with mitochondrial diseases and coenzyme Q10 (CoQ) deficiency. The assessment of CoQ status requires the biochemical determination of CoQ in biological fluids and different cell types, but no methods have been developed as yet for the analysis of CoQ in excretory systems. The aim of this study was to standardize a new procedure for urinary CoQ determination and to establish reference values for a paediatric population. Urinary CoQ was analyzed by HPLC with electrochemical detection...
November 2015: BioFactors
https://www.readbyqxmd.com/read/26674282/participation-of-heart-mitochondria-in-myocardial-protection-against-ischemia-reperfusion-injury-benefit-effects-of-short-term-adaptation-processes
#12
M Ferko, I Kancirová, M Jašová, I Waczulíková, S Čarnická, J Kucharská, O Uličná, O Vančová, M Muráriková, T Ravingerová, A Ziegelhöffer
Acute streptozotocin diabetes mellitus (DM) as well as remote ischemic preconditioning (RPC) has shown a favorable effect on the postischemic-reperfusion function of the myocardium. Cardioprotective mechanisms offered by these experimental models involve the mitochondria with the changes in functional properties of membrane as the end-effector. The aim was to find out whether separate effects of RPC and DM would stimulate the mechanisms of cardioprotection to a maximal level or whether RPC and DM conditions would cooperate in stimulation of cardioprotection...
2015: Physiological Research
https://www.readbyqxmd.com/read/26636879/erratum-neutral-atom-frequency-reference-in-the-deep-ultraviolet-with-fractional-uncertainty-5-7%C3%A3-10-15-phys-rev-lett-108-183004-2012
#13
J J McFerran, L Yi, S Mejri, S Di Manno, W Zhang, J Guéna, Y Le Coq, S Bize
No abstract text is available yet for this article.
November 20, 2015: Physical Review Letters
https://www.readbyqxmd.com/read/26548719/coenzyme-q0-regulates-nf%C3%AE%C2%BAb-ap-1-activation-and-enhances-nrf2-stabilization-in-attenuation-of-lps-induced-inflammation-and-redox-imbalance-evidence-from-in-vitro-and-in-vivo-studies
#14
Hsin-Ling Yang, Ming-Wei Lin, Mallikarjuna Korivi, Jia-Jiuan Wu, Chun-Huei Liao, Chia-Ting Chang, Jiunn-Wang Liao, You-Cheng Hseu
Coenzyme Q (CoQ) analogs with variable number of isoprenoid units have been demonstrated as anti-inflammatory and antioxidant/pro-oxidant molecules. In this study we used CoQ0 (2,3-dimethoxy-5-methyl-1,4-benzoquinone, zero isoprenoid side-chains), a novel quinone derivative, and investigated its molecular actions against LPS-induced inflammation and redox imbalance in murine RAW264.7 macrophages and mice. In LPS-stimulated macrophages, non-cytotoxic concentrations of CoQ0 (2.5-10 μM) inhibited iNOS/COX-2 protein expressions with subsequent reductions of NO, PGE2, TNF-α and IL-1β secretions...
February 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/26436041/effectiveness-of-coq10-oral-supplements-as-an-adjunct-to-scaling-and-root-planing-in-improving-periodontal-health
#15
Sathish Manthena, Mulpuri Venkata Ramoji Rao, Lakshmi Preethi Penubolu, Madhusudhan Putcha, Anumolu Venkata Naga Sri Harsha
INTRODUCTION: Deficiency of CoQ 10 was found in human inflamed gingiva and has been found to be responsible for periodontal destruction. AIM: To evaluate the effectiveness of CoQ 10 supplementation as an adjunct to scaling and rootplaning in reducing gingival inflammation and periodontal pocket depth. MATERIALS AND METHODS: The study was a randomized, double-blind, controlled, parallel group design clinical trial. Thirty subjects with plaque induced gingival inflammation and having atleast three nonadjacent interproximal sites with a probing pocket depth ≥ 5mm were included in the study...
August 2015: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/26348871/anti-angiogenic-properties-of-coenzyme-q0-through-downregulation-of-mmp-9-nf-%C3%AE%C2%BAb-and-upregulation-of-ho-1-signaling-in-tnf-%C3%AE-activated-human-endothelial-cells
#16
Hsin-Ling Yang, Mallikarjuna Korivi, Ming-Wei Lin, Ssu-Ching Chen, Chih-Wei Chou, You-Cheng Hseu
Various coenzyme Q (CoQ) analogs have been reported as anti-inflammatory and antioxidant substances. However, coenzyme Q0 (CoQ0, 2,3-dimethoxy-5-methyl-1,4-benzoquinone), a novel quinone derivative, has not been well studied for its pharmacological efficacies, and its response to cytokine stimulation remains unclear. Therefore, we investigated the potential anti-angiogenic properties of CoQ0 in human endothelial (EA.hy 926) cells against tumor necrosis factor-α (TNF-α) stimulation. We found that the non-cytotoxic concentrations of CoQ0 (2...
November 1, 2015: Biochemical Pharmacology
https://www.readbyqxmd.com/read/26306151/inhibition-of-coenzyme-qs-accumulation-in-engineered-escherichia-coli-by-high-concentration-of-farnesyl-diphosphate
#17
Mojtaba Samoudi, Negar Omid Yeganeh, Hossein Shahbani Zahiri, Parvin Shariati, Reza Hajhosseini
BACKGROUND: Coenzyme Q 10 (CoQ 10 ) is an isoprenoid component used widely in nutraceutical industries. Farnesyl diphosphate synthase (FPPS) is a responsible enzyme for biosynthesis of farnesyl diphosphate (FPP), a key precursor for CoQs production. This research involved investigating the effect of FPPS over-expression on CoQs production in engineered CoQ 10 -producing Escherichia coli (E. coli). METHODS: Two CoQ 10 -producing strains, as referred to E. coli Ba and E...
July 2015: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/26251450/structural-and-biochemical-studies-reveal-ubig-coq3-as-a-class-of-novel-membrane-binding-proteins
#18
Yuwei Zhu, Bo Wu, Xu Zhang, Xiaojiao Fan, Liwen Niu, Xu Li, Junfeng Wang, Maikun Teng
UbiG and Coq3 (orthologue in eukaryotes) are SAM-MTases (S-adenosylmethionine-dependent methyltransferases) that catalyse both O-methylation steps in CoQ biosynthesis from prokaryotes to eukaryotes. However, the detailed molecular mechanism by which they function remains elusive. In the present paper, we report that UbiG/Coq3 defines a novel class of membrane-binding proteins. Escherichia coli UbiG binds specifically to liposomes containing PG (phosphatidylglycerol) or CL (cardiolipin, or diphosphatidylglycerol), two major lipid components of the E...
August 15, 2015: Biochemical Journal
https://www.readbyqxmd.com/read/26049051/coenzyme-q-dependent-mitochondrial-respiratory-chain-activity-in-granulosa-cells-is-reduced-with-aging
#19
COMPARATIVE STUDY
Assaf Ben-Meir, Shlomi Yahalomi, Brit Moshe, Yoel Shufaro, Benjamin Reubinoff, Ann Saada
OBJECTIVE: To examine coenzyme Q10 (CoQ10)-dependent mitochondrial respiratory chain (MRC) activity in granulosa cells (GC) with aging and examine the effect of in vitro CoQ supplementation. DESIGN: Experimental study. SETTING: Hospital laboratory. PATIENT(S): Ten younger (<32 years) and 10 older (>39 years) patients undergoing in vitro fertilization (IVF) treatment. INTERVENTION(S): Measurement of succinate-cytochrome c reductase (MRC complex II + III) activity in the presence and absence of CoQ1 (a soluble CoQ analog)...
September 2015: Fertility and Sterility
https://www.readbyqxmd.com/read/25669678/remote-ischemic-preconditioning-of-the-heart-protective-responses-in-functional-and-biophysical-properties-of-cardiac-mitochondria
#20
M Ferko, I Kancirová, M Jašová, S Čarnická, M Muráriková, I Waczulíková, Z Sumbalová, J Kucharská, O Uličná, T Ravingerová, A Ziegelhöffer
UNLABELLED: Remote ischemic preconditioning (RIP)-induced protection of myocardial energetics was well documented on the level of tissue, but data concerning the involvement of mitochondria were missing. We aimed at the identification of changes in membrane properties and respiratory functions induced in rat heart mitochondria by RIP. Experiments were performed on 46 male Wistar rats divided into control and RIP-treated groups of 21 animals each. Blood flow in the occluded area was recorded by MRI angiography in four animals...
2014: Physiological Research
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