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Pediatric acute kidney injury

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https://www.readbyqxmd.com/read/29775446/-chronic-kidney-disease-in-children-up-to-2-years-of-age-a-single-center-data-analysis
#1
Kinga Musiał, Marta Sałamacha, Sylwia Gralec, Anna Pers, Łukasz Jacheć, Danuta Zwolińska
Although anomalies in the urinary tract are the leading cause of chronic kidney disease (CKD) in the pediatric population, there are few studies focusing on etiological discrepancies between younger and older children. AIM: The aim of the study was to perform a comparative analysis of etiology of CKD in children hospitalized in the Department of Pediatric Nephrology at the Wrocław Medical University, with reference to the patients' age and gender. MATERIALS AND METHODS: The retrospective analysis considered medical records of 174 patients aged 0-18 years, diagnosed with CKD, hospitalized in our Department in the years 2011-2017...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29766640/subclinical-inflammation-phenotypes-and-long-term-outcomes-after-pediatric-kidney-transplantation
#2
Michael E Seifert, Megan V Yanik, Daniel I Feig, Vera Hauptfeld-Dolejsek, Elizabeth C Mroczek-Musulman, David R Kelly, Frida Rosenblum, Roslyn B Mannon
The implementation of surveillance biopsies in pediatric kidney transplantation remains controversial. Surveillance biopsies detect subclinical injury prior to clinical dysfunction, which could allow for early interventions that prolong allograft survival. We conducted a single-center retrospective cohort study of 120 consecutive pediatric kidney recipients, of whom 103 had surveillance biopsies ≤ 6 months post-transplant. We tested the hypothesis that subclinical inflammation (borderline or T cell-mediated rejection without clinical dysfunction) is associated with a 5-year composite endpoint of acute rejection and allograft failure...
May 15, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29765932/fluid-overload-and-renal-angina-index-at-admission-are-associated-with-worse-outcomes-in-critically-ill-children
#3
Sidharth K Sethi, Veena Raghunathan, Shilpi Shah, Maninder Dhaliwal, Pranaw Jha, Maneesh Kumar, Sravanthi Paluri, Shyam Bansal, Maroun J Mhanna, Rupesh Raina
Objectives: We investigated the association of fluid overload and oxygenation in critically sick children, and their correlation with various outcomes (duration of ventilation, ICU stay, and mortality). We also assessed whether renal angina index (RAI) at admission can predict mortality or acute kidney injury (AKI) on day 3 after admission. Design and setting: Prospective study, pediatric intensive care in a tertiary hospital. Duration: June 2013-June 2014. Patients: Patients were included if they needed invasive mechanical ventilation for >24 h and had an indwelling arterial catheter...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29733487/the-prognostic-value-of-urinary-chemokines-at-6-months-after-pediatric-kidney-transplantation
#4
Claire Mockler, Atul Sharma, Ian W Gibson, Ang Gao, Alexander Wong, Julie Ho, Tom D Blydt-Hansen
Pediatric kidney transplantation is lifesaving, but long-term allograft survival is still limited by injury processes mediated by alloimmune inflammation that may otherwise be clinically silent. Chemokines associated with alloimmune inflammation may offer prognostic value early post-transplant by identifying patients at increased risk of poor graft outcomes. We conducted a single-center prospective cohort study of consecutive pediatric kidney transplant recipients (<19 years). Urinary CCL2 and CXCL10 measured at 6 months post-transplant were evaluated for association with long-term eGFR decline, allograft survival, and concomitant acute cellular rejection histology...
May 7, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29732396/incidence-and-outcomes-of-neonatal-acute-kidney-injury-awaken-a-multicentre-multinational-observational-cohort-study
#5
Jennifer G Jetton, Louis J Boohaker, Sidharth K Sethi, Sanjay Wazir, Smriti Rohatgi, Danielle E Soranno, Aftab S Chishti, Robert Woroniecki, Cherry Mammen, Jonathan R Swanson, Shanty Sridhar, Craig S Wong, Juan C Kupferman, Russell L Griffin, David J Askenazi
Background: Single-center studies suggest that neonatal acute kidney injury (AKI) is associated with poor outcomes. However, inferences regarding the association between AKI, mortality, and hospital length of stay are limited due to the small sample size of those studies. In order to determine whether neonatal AKI is independently associated with increased mortality and longer hospital stay, we analyzed the Assessment of Worldwide Acute Kidney Epidemiology in Neonates (AWAKEN) database...
November 2017: The lancet child & adolescent health
https://www.readbyqxmd.com/read/29715307/recognition-and-management-of-acute-kidney-injury-in-children-the-isn-0by25-global-snapshot-study
#6
Etienne Macedo, Jorge Cerdá, Sangeeta Hingorani, Jiayi Hou, Arvind Bagga, Emmanuel Almeida Burdmann, Michael Rocco V, Ravindra Mehta L
BACKGROUND: In low and middle-income countries, reliable data on the epidemiology of childhood acute kidney injury (AKI) is lacking. The Global Snapshot, conducted by the ISN "0by25" AKI initiative, was a world-wide cross-sectional, observational study to evaluate AKI in hospitalized patients. Here we report the pediatric results of this study. PATIENTS AND METHODS: We prospectively collected data on children who met the Kidney Disease Improving Global Outcomes AKI criteria during a 10-week window in late 2014...
2018: PloS One
https://www.readbyqxmd.com/read/29712717/long-term-mortality-after-acute-kidney-injury-in-the-pediatric-icu
#7
Erin Hessey, Geneviève Morissette, Jacques Lacroix, Sylvie Perreault, Susan Samuel, Marc Dorais, Philippe Jouvet, Jean-Philippe Lafrance, Jacques LeLorier, Véronique Phan, Ana Palijan, Michael Pizzi, Louise Roy, Michael Zappitelli
OBJECTIVES: (1) To evaluate the association between acute kidney injury (AKI) in the PICU and long-term mortality and (2) to determine the extent to which adding the urine output (UO)-defined AKI alters the association. METHODS: A 2-center retrospective cohort study of children (≤18 years old) admitted to the PICU between 2003 and 2005 for noncardiac surgery, with follow-up until 2010. Patients with end stage renal disease, no provincial health insurance number, who died during hospitalization, or could not be linked to administrative data were excluded...
May 2018: Hospital Pediatrics
https://www.readbyqxmd.com/read/29678895/healthcare-utilization-after-acute-kidney-injury-in-the-pediatric-intensive-care-unit
#8
Erin Hessey, Geneviève Morissette, Jacques Lacroix, Sylvie Perreault, Susan Samuel, Marc Dorais, Véronique Phan, Philippe Jouvet, Jean-Philippe Lafrance, Jacques LeLorier, Ana Palijan, Michael Pizzi, Louise Roy, Michael Zappitelli
BACKGROUND AND OBJECTIVES: Little is known about the long-term burden of AKI in the pediatric intensive care unit. We aim to evaluate if pediatric AKI is associated with higher health service use post-hospital discharge. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: This is a retrospective cohort study of children (≤18 years old) admitted to two tertiary centers in Montreal, Canada. Only the first admission per patient was included. AKI was defined in two ways: serum creatinine alone or serum creatinine and/or urine output...
April 20, 2018: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/29677008/evolution-of-acute-kidney-injury-and-its-association-with-systemic-hemodynamics-in-children-with-fluid-refractory-septic-shock
#9
Akash Deep, Hiremath Sagar, Chulananda Goonasekera, Palaniswamy Karthikeyan, Joe Brierley, Abdel Douiri
OBJECTIVES: There are no studies in pediatrics evaluating the progression of acute kidney injury in septic shock. We investigated the evolution of sepsis-associated acute kidney injury and its association with systemic hemodynamics in children with fluid-refractory septic shock. DESIGN: Prospective cohort study. SETTING: PICU of a tertiary care hospital. PATIENTS: All patients with fluid-refractory septic shock (n = 61) between September 2010 and February 2014...
April 19, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29657372/targeted-interventions-in-critically-ill-children-with-severe-dengue
#10
Suchitra Ranjit, Gokul Ramanathan, Balasubramaniam Ramakrishnan, Niranjan Kissoon
Background: The World Health Organization guidelines provide suggestions on early recognition and treatment of severe dengue (SD); however, mortality in this group can be high and is related both to disease severity and the treatment complications. Subjects and Methods: In this prospective observational study, we report our results where standard therapy (ST) was enhanced by Intensive Care Unit (ICU) supportive measures that have proven beneficial in other conditions that share similar pathophysiology of capillary leak and fluid overload...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29643892/association-of-in-hospital-outcome-of-acute-kidney-injury-aki-with-etiology-among-newborns-at-a-tertiary-care-unit
#11
Muhammad Asghar Ali, Abdur Rehman, Ejaz Ahmed
Objective: To determine association of in-hospital outcome of AKI with etiology in newborns at a tertiary care hospital. Methods: This descriptive cross-sectional study was conducted at Department of Pediatric Neonatology, The Children's Hospital and Institute of the Child Health, Multan by using non-probability purposive sampling technique from June 2016 to June 2017. A total of 101 newborns diagnosed with acute kidney injury were registered. Etiological factors were assessed and these patients were followed till discharge to monitor in-hospital outcomes...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29643888/spectrum-of-complications-of-severe-dka-in-children-in-pediatric-intensive-care-unit
#12
Qalab Abbas, Saba Arbab, Anwar Ul Haque, Khadija Nuzhat Humayun
Objectives: To describe the spectrum of complications of Diabetic Ketoacidosis (DKA) observed in children admitted with severe DKA. Methods: Retrospective review of the medical records of all children admitted with the diagnosis of severe DKA in Pediatric Intensive Care Unit (PICU) of the Aga Khan University Hospital, from January 2010 to December 2015 was done. Data was collected on a structured proforma and descriptive statistics were applied. Results: Total 37 children were admitted with complicated DKA (1...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29630083/renal-microsporidiosis-in-pediatric-bone-marrow-transplant-recipients-a-case-series
#13
Saloni Shah, Sheba Sweetline Jacob, Rama Mani, Ashok Parameswaran, Sunil Kumar, Rajeev A Annigeri, Raja Mahesh, Ramya Uppuluri
Microsporidiosis is a rare, but emerging opportunistic infection in solid organ transplant and stem cell transplant recipients. Renal involvement in microsporidiosis is very rarely seen in these recipients. We describe two cases of pediatric renal microsporidiosis, diagnosed on renal biopsies, following bone marrow transplantation presenting as severe acute kidney injury. The first patient died, whereas the second survived due to early diagnosis based on high index of suspicion and prompt treatment with Albendazole...
April 9, 2018: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/29628970/acute-kidney-injury-in-pediatric-patients-with-rhabdomyolysis
#14
Young Shin Lim, Heeyeon Cho, Sang Taek Lee, Yeonhee Lee
Purpose: This study aimed to evaluate the clinical findings in pediatric rhabdomyolysis and the predictive factors for acute kidney injury (AKI) in Korean children. Methods: Medical records of 39 Korean children, who were newly diagnosed with rhabdomyolysis from January 2008 to December 2015, were retrospectively analyzed. The diagnosis was made from the medical history, elevated serum creatinine kinase level >1,000 IU/L, and plasma myoglobin level >150 ng/mL...
March 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29620706/furosemide-response-predicts-acute-kidney-injury-after-cardiac-surgery-in-infants-and-neonates
#15
Santiago Borasino, Kevin M Wall, Jack H Crawford, Kristal M Hock, David C Cleveland, Fazlur Rahman, Kimberly D Martin, Jeffrey A Alten
OBJECTIVE: Cardiac surgery-induced acute kidney injury occurs frequently in neonates and infants and is associated with postoperative morbidity/mortality; early identification of cardiac surgery-induced acute kidney injury may be crucial to mitigate postoperative morbidity. We sought to determine if hourly or 6-hour cumulative urine output after furosemide in the first 24 hours after cardiopulmonary bypass could predict development of cardiac surgery-induced acute kidney injury and other deleterious outcomes...
April 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29617846/eresearch-in-acute-kidney-injury-a-primer-for-electronic-health-record-research
#16
Emily L Joyce, Dilhari R DeAlmeida, Dana Y Fuhrman, Priyanka Priyanka, John A Kellum
Acute kidney injury (AKI) has a significant impact on patient morbidity and mortality as well as overall health care costs. eResearch, which integrates information technology and information management to optimize research strategies, provides a perfect platform for necessary ongoing AKI research. With the recent adoption of a widely accepted definition of AKI and near-universal use of electronic health records, eResearch is becoming an important tool in AKI research. Conducting eResearch in AKI should ideally be based on a relatively uniform methodology...
March 30, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29597226/pediatric-continuous-renal-replacement-therapy-for-40-years-of-continuous-renal-replacement-therapy
#17
Stuart L Goldstein
The provision of continuous renal replacement therapy (CRRT) to pediatric patients presents numerous clinical and technical challenges that have been addressed over the past 40 years. Children provide an informative population for acute kidney injury and CRRT study, as pediatric subspecialists practice with a preventive perspective and children often do not have the multiple severe chronic comorbidities that confound adult studies. In addition, the relatively small number of patients treated at any one pediatric center has engendered successful multicenter collaboration to advance the clinical and technical studies of CRRT provision...
2018: Contributions to Nephrology
https://www.readbyqxmd.com/read/29593188/risk-factor-of-mortality-in-indonesian-children-with-cerebral-palsy
#18
Indra Gunawan Prastiya, Vitria Prasetyo Risky, Irmawati Mira, Asih Setyoningrum Retno, Saharso Darto, Prasetyo Erny
OBJECTIVE: Individuals with CP have a lower life expectancy than the general population. The objective of the study is to investigate the risk factor of mortality in Indonesian children with CP. METHODS: An observational analytic study was conducted using medical records at pediatric ward Dr. Soetomo Hospital, Surabaya, Indonesia, from January 2014 to December 2016. Inclusion criteria was all of CP patients in that were hospitalized from 6 months to 14 year of age...
2018: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/29590376/incidence-of-nephrotoxicity-among-pediatric-patients-receiving-vancomycin-with-either-piperacillin-tazobactam-or-cefepime-a-cohort-study
#19
Kathryn M Cook, Jessica Gillon, Alison G Grisso, Ritu Banerjee, Natalia Jimenez-Truque, Elizabeth J Phillips, Sara L Van Driest
Background: Recent studies in adults have found an incidence of acute kidney injury (AKI) in patients treated with a combination of vancomycin and piperacillin-tazobactam (TZP) that is greater than that expected with either medication alone. The purpose of this study was to determine whether combination therapy with vancomycin and TZP is associated with an incidence of AKI in pediatric patients higher than that in those on combination therapy with vancomycin and cefepime. Methods: We performed a retrospective single-center matched-cohort study of pediatric patients who received vancomycin in combination with TZP or cefepime between January 2015 and June 2016...
March 26, 2018: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/29572749/eculizumab-treatment-in-severe-pediatric-stec-hus-a-multicenter-retrospective-study
#20
Lucas Percheron, Raluca Gramada, Stéphanie Tellier, Remi Salomon, Jérôme Harambat, Brigitte Llanas, Marc Fila, Emma Allain-Launay, Anne-Laure Lapeyraque, Valerie Leroy, Anne-Laure Adra, Etienne Bérard, Guylhène Bourdat-Michel, Hassid Chehade, Philippe Eckart, Elodie Merieau, Christine Piètrement, Anne-Laure Sellier-Leclerc, Véronique Frémeaux-Bacchi, Chloe Dimeglio, Arnaud Garnier
BACKGROUND: Hemolytic uremic syndrome related to Shiga-toxin-secreting Escherichia coli infection (STEC-HUS) remains a common cause of acute kidney injury in young children. No specific treatment has been validated for this severe disease. Recently, experimental studies highlight the potential role of complement in STEC-HUS pathophysiology. Eculizumab (EC), a monoclonal antibody against terminal complement complex, has been used in severe STEC-HUS patients, mostly during the 2011 German outbreak, with conflicting results...
March 23, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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