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https://www.readbyqxmd.com/read/29034234/interleukin-13-in-asthma-and-other-eosinophilic-disorders
#1
Emma Doran, Fang Cai, Cécile T J Holweg, Kit Wong, Jochen Brumm, Joseph R Arron
Asthma is characterized by episodic, reversible airflow obstruction associated with variable levels of inflammation. Over the past several decades, there has been an increasing appreciation that the clinical presentation of asthma comprises a diverse set of underlying pathologies. Rather than being viewed as a single disease entity, asthma is now thought of as a clinical syndrome with the involvement of multiple pathological mechanisms. While it is appreciated that eosinophilia is present in only a subset of patients, it remains a key feature of asthma and other eosinophilic disorders such as atopic dermatitis, eosinophilic esophagitis, and chronic rhinosinusitis with nasal polyps...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29033449/symptomatology-patterns-in-children-with-allergic-rhinitis
#2
Michael Katotomichelakis, Theodoros Iliou, Ioannis Karvelis, Evangelos Giotakis, Gerasimos Daniilides, Eleni Erkotidou, Christos Lazaridis, George K Anastassopoulos
BACKGROUND Although allergic rhinitis (AR) is recognized as a growing global health disease with considerable importance for patients' lives, especially among children and adolescents, there is a lack of population studies concerning symptomatology patterns of the disease. The present study aimed to explore symptoms prevalence among school-aged children, to detect any correlation between allergen sensitivities with symptomatology patterns, and, finally, to evaluate the association of the sensitivity grade score with symptoms severity or seasonality...
October 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29033342/intentional-cyanoacrylate-ingestion-a-rare-cause-of-delayed-gastric-perforation-requiring-gastric-wedge-resection
#3
Sun Hwa Lee, Seong Jong Yun, Seokyong Ryu, Seung Won Choi, Hye Jin Kim, Tae Kyung Kang, Sung Chan Oh, Suk Jin Cho
Cyanoacrylate (LOCTITE® 401™) is a fast-acting adhesive available nationwide, with medical and household uses. Most cases of cyanoacrylate exposure are accidental and occur in children less than 5years old. Various routes of exposure have been reported including the dermal, oral, ocular, otic, nasal, and urethral routes; however, very few result in serious complication and mortality. Although a few cases of airway obstruction related to cyanoacrylate ingestion have been reported, intentional cyanoacrylate ingestion-induced gastrointestinal tract injury has scarcely been reported...
October 7, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29031172/a-parapharyngeal-space-schwannoma-arising-from-the-vagus-nerve-a-case-report
#4
Conor Carroll, Manish Jagatiya, Dia Kamel, Jamal Siddiqi
INTRODUCTION: Tumours of the parapharyngeal space are rare. Only 0.5% of head and neck tumours occur in this space. Surgical excision of parapharyngeal space lesions is challenging because of the anatomical complexity of the area. PRESENTATION OF CASE: A 31-year-old male patient was referred by his general dental practitioner for removal of lower wisdom teeth due to multiple episodes of pericoronitis. At the initial examination, an incidental finding was made of a large fluctuant posterior oropharyngeal swelling...
October 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29026961/outcome-of-in-situ-septoplasty-and-extracorporeal-subtotal-septal-reconstruction-in-crooked-noses-a-randomized-self-controlled-study
#5
Sercan Gode, Murat Benzer, Mustafa Uslu, Isa Kaya, Rasit Midilli, Bulent Karci
IMPORTANCE: Severe dorsal deviations in crooked noses are treated by either in situ septoplasty with asymmetric spreader grafts (ISS) or extracorporeal subtotal septal reconstruction (ECS). To our knowledge, except one retrospective study, there is no other that compares the objective and subjective results of these two treatment modalities. OBJECTIVE: The aim of this study was to compare the aesthetic and functional outcomes of ECS and ISS in crooked noses. DESIGN, SETTING AND PARTICIPANTS: This study was carried out on 40 patients (ISS in 20 patients and ECS in 20 patients) who underwent external rhinoplasty surgery due to crooked noses between May 2014 and January 2016...
October 12, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29018504/hmgb1-in-the-pathogenesis-of-nasal-inflammatory-diseases-and-its-inhibition-as-new-therapeutic-approach-a-review-from-the-literature
#6
REVIEW
Luisa Maria Bellussi, Serena Cocca, Giulio Cesare Passali, Desideri Passali
Introduction  This study is a systematic review on recent developments about the importance of HMGB1 protein in the pathogenesis of rhino-sinusal inflammatory diseases. We also report data on the use of 18-β-glycyrrhetic acid (GA), which has been shown able to inhibit the pro-inflammatory activities of HMGB1, in young patients affected by allergic rhinitis and complaining of nasal obstruction as main symptom. Objectives  The objective of this study was to review the literature to demonstrate the importance of HMGB1 in the pathogenesis of nasal inflammatory disorders and understand whether the inhibition of this protein may be an efficacious and innovative therapeutic strategy for patients with rhino-sinusal inflammation...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/29018500/computed-tomography-measurement-of-inferior-turbinate-in-asymptomatic-adult
#7
Mohammad Waheed El-Anwar, Atef A Hamed, Ghada Abdulmonaem, Ismail Elnashar, Inas M Elfiki
Introduction  The inferior turbinate (IT) is the most susceptible turbinate to enlargement causing nasal obstruction. The common belief ascribes most of the enlargement of the IT to mucosal elements. Objective  This study aimed to investigate the detailed computed tomography (CT) measurement of the IT in asymptomatic adult by determining the thickness of both the non-bony (mucosa) and bony parts and their relation to nasal air space in different related areas of the nose. Methods  We included in the study paranasal CT scans of 108 individuals (216 IT) that had no paranasal pathology...
October 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28990834/eustachian-tube-evaluation-in-patients-with-obstructive-sleep-apnea-syndrome
#8
Giuseppe Magliulo, Marco de Vincentiis, Giannicola Iannella, Andrea Ciofalo, Alessandra Manno, Benedetta Pasquariello, Diletta Angeletti, Annalisa Pace, Giampiero Gulotta, Antonella Polimeni
OBJECTIVES: Investigate the presence of Eustachian Tube Dysfunction (ETD) in Obstructive sleep apnea (OSA) patients. Correlate the ET function and the severity of the sleep apnea syndrome. Correlate nasal resistance and nasal mucociliary clearance with the onset of ETD in these patients. MATERIALS AND METHODS: Forty patients affected by OSA were enrolled in our clinical prospective study. Thirty patients were also investigated as a control group. All of the analyzed subjects underwent ENT examination, anterior rhinomanometry and test for mucociliary transport time...
October 9, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28988544/molecular-and-clinical-characterization-of-human-respiratory-syncytial-virus-in-south-korea-between-2009-and-2014
#9
E Park, P H Park, J W Huh, H J Yun, H K Lee, M H Yoon, S Lee, G Ko
Respiratory syncytial virus (RSV) can cause serious respiratory infections, second only to influenza virus. In order to know RSV's genetic changes we examined 4028 respiratory specimens from local hospital outpatients in Gyeonggi Province, South Korea over six consecutive years by real-time one-step RT-PCR; 183 patients were positive for RSV infection. To investigate the specific distribution of RSV genotypes, we performed partial sequencing of the glycoprotein gene. Of the 131 RSV-A specimens sequenced, 61 (43·3%) belonged to the ON1 genotype, 66 (46·8%) were NA1 genotype, 3 (2·1%) were GA5 genotype, and 1 (0·7%) belonged to the GA1 genotype...
October 9, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28988259/a-straight-choice-avoiding-septal-re-deviation-using-titanium-plates-a-16-year-retrospective-patient-follow-up-evaluation
#10
J M Godoy S, J M Godoy, A Godoy, C Revelo
BACKGROUND: To propose a new surgical technique for fixing the nasal septum to the midline, for long term prevention of nasal obstruction, in secondary and select cases of primary septoplasty. METHODOLOGY: Retrospective study, within hospital medical center. PATIENTS: Two hundred and twenty two patients who underwent septoplasty. Data collection occurred consecutively between March 1st of 2000 and May 1st 2016. Twenty six percent females and seventy four percent males...
October 8, 2017: Rhinology
https://www.readbyqxmd.com/read/28988100/-silent-sleep-apnea-in-dentofacial-deformities-and-prevalence-of-daytime-sleepiness-after-orthognathic-and-intranasal-surgery
#11
Jeffrey C Posnick, Anayo Adachie, Neeru Singh, Elbert Choi
PURPOSE: The purposes of this study were to determine the occurrence of undiagnosed "silent" obstructive sleep apnea (OSA) in dentofacial deformity (DFD) patients at initial surgical presentation and to report on the level of daytime sleepiness in DFD patients with OSA and chronic obstructive nasal breathing (CONB) after undergoing bimaxillary, chin, and intranasal surgery. MATERIALS AND METHODS: A retrospective cohort study of patients with a bimaxillary DFD and CONB was implemented...
September 11, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28983574/unilateral-nasal-obstruction
#12
Samantha J Mikals, Austin M McCuiston, Murugappan Ramanathan
No abstract text is available yet for this article.
October 5, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28980598/-differential-diagnostics-and-the-treatment-strategy-for-the-management-of-the-nasopharyngeal-cystic-lesions
#13
G Yu Tsarapkin, A S Tovmasyan, S G Arzamazov, A E Kishinevskii
The nasopharyngeal cystic lesions are quite common (affecting up to 14% of the general population) even though the majority of the cases are asymptomatic. Sometimes this condition is associated with the obstruction of nasal breathing, runny nose, hearing impairment, and other non-specific clinical manifestations. The endoscopic examination of the nasal cavity allows the preliminary clinical diagnosis to be established, however, MRI and CT visualization are necessary for more reliable differential diagnostics of this pathology and adequate planning of its treatment...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/28978272/suspected-rhinolithiasis-associated-with-endodontic-disease-in-a-cat
#14
Kevin Ng, Nadine Fiani, Santiago Peralta
Rhinoliths are rare, intranasal, mineralized masses formed via the precipitation of mineral salts around an intranasal nidus. Clinical signs are typically consistent with inflammatory rhinitis and nasal obstruction, but asymptomatic cases are possible. Rhinoliths may be classified as exogenous or endogenous depending on the origin of the nidus, with endogenous rhinoliths reportedly being less common. This case report describes a suspected case of endogenous rhinolithiasis in a cat which was detected as an incidental finding during radiographic assessment of a maxillary canine tooth with endodontic disease...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28975810/eustachian-tube-dysfunction-related-symptoms-in-chronic-nasal-obstruction-caused-by-inferior-turbinate-enlargement
#15
Teemu Harju, Ilkka Kivekäs, Jura Numminen, Markus Rautiainen
OBJECTIVE: The aim of this study was to evaluate the relationship between chronic nasal obstruction caused by inferior turbinate enlargement and Eustachian tube dysfunction-related symptoms using the Eustachian Tube Dysfunction Questionnaire (ETDQ-7) as an assessment method. METHODS: A total of 80 adults were enrolled. Group 1 comprised consecutive patients with enlarged inferior turbinates and group 2 comprised healthy controls. The ETDQ-7 scores and tympanometry results of both groups were analyzed and compared...
October 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28969258/esthesioneuroblastoma-presenting-with-bilateral-proptosis-and-blindness-in-a-child-a-case-report
#16
Mahdi Shahriari, Nader Shakibazad, Mehrpour Moradi
Esthesioneuroblastoma is a rare malignant tumour of the olfactory epithelium. The most common symptom is related to unilateral nasal obstruction. It rarely presents with bilateral proptosis and blindness. We report a 21-month-old girl with esthesioneuroblastoma in sphenoid and ethmoid sinus in a child presenting with bilateral proptosis, blindness, and irritability. The diagnosis was confirmed by histopathology.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28967532/outcomes-of-septorhinoplasty-a-new-approach-comparing-functional-and-aesthetic-results
#17
T Radulesco, M Penicaud, L Santini, J-M Thomassin, P Dessi, J Michel
The aim of this study was to compare objective and subjective functional results of septorhinoplasty with subjective aesthetic results. A prospective study was performed including global and subgroup analyses (primary versus secondary septorhinoplasty). Three instruments were used to evaluate pre- and postoperative results: rhinomanometry for the objective functional analysis, the Nasal Symptom Obstruction Evaluation (NOSE) scale for the subjective functional analysis, and the Rhinoplasty Outcome Evaluation (ROE) scale for the subjective aesthetic analysis...
September 26, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28966735/continuous-positive-airway-pressure-is-it-a-route-for-infection-in-those-with-obstructive-sleep-apnoea
#18
Liam Mercieca, Richard Pullicino, Kyra Camilleri, Rodianne Abela, Sean Apap Mangion, Julian Cassar, Matthew Zammit, Christine Gatt, Christopher Deguara, Christopher Barbara, Peter Fsadni, Stephen Montefort
INTRODUCTION: Continuous positive airway pressure (CPAP) is the standard treatment for obstructive sleep apnoea (OSA), with limited data about the prevalence of respiratory infections and microbial colonization in these patients. OBJECTIVES: The aim of this study was to determine if CPAP use is associated with respiratory infections and to identify the organisms that colonize or infect these patients. METHOD: A retrospective, case-controlled study in patients diagnosed with OSA was carried out...
January 2017: Sleep Science
https://www.readbyqxmd.com/read/28966076/sleep-apnea-metabolic-disease-and-the-cutting-edge-of-therapy
#19
Matthew Light, Karen McCowen, Atul Malhotra, Omar A Mesarwi
Obstructive sleep apnea (OSA) is common, and many cross-sectional and longitudinal studies have established OSA as an independent risk factor for the development of a variety of adverse metabolic disease states, including hypertension, insulin resistance, type 2 diabetes, nonalcoholic fatty liver disease, dyslipidemia, and atherosclerosis. Nasal continuous positive airway pressure (CPAP) has long been the mainstay of therapy for OSA, but definitive studies demonstrating the efficacy of CPAP in improving metabolic outcomes, or in reducing incident disease burden, are lacking; moreover, CPAP has variable rates of adherence...
September 28, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28962626/efficacy-and-usability-of-a-novel-nebulizer-targeting-both-upper-and-lower-airways
#20
Daniela Posa, Antonio Pizzulli, Petra Wagner, Serena Perna, Stephanie Hofmaier, Paolo Maria Matricardi, Susanne Lau
BACKGROUND: Upper and lower airways diseases share in part their pathogenic mechanisms and frequently occur simultaneously as "United Airway Disease." Local treatment with nebulizers delivers anti-symptomatic drugs in either the upper or the lower airways, according to the particle size generated by the nebulizer. To our knowledge, no nebulizer combines both application ways. The aim of this study is to test the efficacy and usability of a new nebulizer (OMRON A3 complete), generating aerosols with particles diameters of 2-4...
September 29, 2017: Italian Journal of Pediatrics
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