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https://www.readbyqxmd.com/read/29040677/navigation-linked-heads-up-display-in-intracranial-surgery-early-experience
#1
Justin R Mascitelli, Leslie Schlachter, Alexander G Chartrain, Holly Oemke, Jeffrey Gilligan, Anthony B Costa, Raj K Shrivastava, Joshua B Bederson
BACKGROUND: The use of intraoperative navigation during microscope cases can be limited when attention needs to be divided between the operative field and the navigation screens. Heads-up display (HUD), also referred to as augmented reality, permits visualization of navigation information during surgery workflow. OBJECTIVE: To detail our initial experience with HUD. METHODS: We retrospectively reviewed patients who underwent HUD-assisted surgery from April 2016 through April 2017...
October 10, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28944277/secondhand-smoke-exposure-and-smoke-free-policy-in-philadelphia-public-housing
#2
Ann C Klassen, Nora L Lee, Aaron Pankiewicz, Rikki Ward, Michelle Shuster, Bethany Townsend Ogbenna, Anita Wade, Maxwell Boamah, Olufunlayo Osayameh, Ana M Rule, Dorota Szymkowiak, Ryan Coffman, Virginius Bragg, Giridhar Mallya
OBJECTIVES: Multi-unit housing environments remain significant sources of secondhand smoke (SHS) exposure, especially for vulnerable populations in subsidized housing. In Philadelphia, the largest US housing authority to implement smoke-free policies, we measured baseline resident smoking-related behaviors and attitudes, and longitudinal exposures to airborne nicotine, during policy development and implementation. METHODS: In 4 communities, we collected data in 2013, 2014, and 2016, before and after introduction of comprehensive smoke-free policies, interviewing persons in 172 households, and monitoring air-borne nicotine in non-smoking homes and public areas...
April 2017: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28935182/eudesmane-sesquiterpenes-from-chinese-liverwort-are-substrates-of-cdrs-and-display-antifungal-activity-by-targeting-erg6-and-erg11-of-candida-albicans
#3
Siwen Li, Hongzhuo Shi, Wenqiang Chang, Yi Li, Ming Zhang, Yanan Qiao, Hongxiang Lou
We isolated twelve sesquiterpenes from Chinese liverwort Tritomaria quinquedentata (Huds.) Buch., including four new compounds. Among them, five eudesmane sesquiterpenes were ineffective against Candida albicans wild strain SC5314 but active towards efflux pumps-deficient strain DSY654 using Alamar blue assay. Further test of the most active agent of ent-isoalantolactone (8, ent-iLL) showed that it also inhibited the yeast-to-hyphal switch of DSY654 cells. The intracellular content measurement using high performance liquid chromatography (HPLC) revealed that ent-iLL was intracellularly accumulated in C...
September 9, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28931264/assessment-of-the-accuracy-and-errors-of-head-up-display-by-an-optical-neuronavigation-system-in-brain-tumor-surgery
#4
Kenichiro Asano, Kosuke Katayama, Kiyohide Kakuta, Kanae Oyama, Hiroki Ohkuma
BACKGROUND: A head-up display (HUD) in which navigational information is projected into the microscope view may enable surgeons to perform operations more efficiently. Projecting depictions of both tumor and important intracranial structures on the HUD may facilitate safe surgery. OBJECTIVE: To investigate accuracy and errors regarding important intracranial structures, errors due to brain shifts, and preservation rates for important intracranial structures. METHODS: A total of 184 surgeries in 172 patients were performed using this operation system...
February 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28930381/intraocular-pressure-and-big-bubble-diameter-in-deep-anterior-lamellar-keratoplasty-an-ex-vivo-microscope-integrated-oct-with-heads-up-display-study
#5
Paramjit K Bhullar, Oscar M Carrasco-Zevallos, Alexandria Dandridge, Neel D Pasricha, Brenton Keller, Liangbo Shen, Joseph A Izatt, Cynthia A Toth, Anthony N Kuo
PURPOSE: To investigate the relationship between intraocular pressure (IOP) and big bubble (BB) formation in a model of deep anterior lamellar keratoplasty (DALK). DESIGN: Ex-vivo. METHODS: Corneoscleral buttons from human donors were loaded onto an artificial anterior chamber connected to a column of balanced salt solution. A surgeon-in-training learned to perform DALK via the BB technique using swept-source microscope-integrated optical coherence tomography (SS-MIOCT) with heads-up display (HUD)...
September 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28871047/axonal-localization-of-neuritin-cpg15-mrna-is-limited-by-competition-for-hud-binding
#6
Cynthia Gomes, Seung Joon Lee, Amy S Gardiner, Terika Smith, Pabitra K Sahoo, Priyanka Patel, Elizabeth Thames, Reycel Rodriguez, Ross Taylor, Soonmoon Yoo, Tilman Heise, Amar N Kar, Nora Perrone-Bizzozero, Jeffery L Twiss
HuD protein has been shown to stabilize mRNAs with AU-rich elements (ARE) in their 3'UTRs, including Gap43 that has been linked to axon growth. HuD also binds to Neuritin (Nrn1), whose 3'UTR contains ARE sequences. Although Nrn1's 3'UTR was shown to have axonal localizing activity in embryonic hippocampal neurons, it was not active in adult DRG neurons. Here, we asked why the 3'UTR is not sufficient to localize Nrn1 mRNA into DRG axons. HuD overexpression increases the axonal localizing activity of Nrn1's 3'UTR in DRG...
September 4, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28860962/cell-proliferation-migration-and-neurogenesis-in-the-adult-brain-of-the-pulse-type-weakly-electric-fish-gymnotus-omarorum
#7
Valentina Olivera-Pasilio, Moira Lasserre, María E Castelló
Adult neurogenesis, an essential mechanism of brain plasticity, enables brain development along postnatal life, constant addition of new neurons, neuronal turnover, and/or regeneration. It is amply distributed but negatively modulated during development and along evolution. Widespread cell proliferation, high neurogenic, and regenerative capacities are considered characteristics of teleost brains during adulthood. These anamniotes are promising models to depict factors that modulate cell proliferation, migration, and neurogenesis, and might be intervened to promote brain plasticity in mammals...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28851914/simulated-forward-and-backward-self-motion-based-on-realistic-parameters-causes-motion-induced-blindness
#8
Victoria Thomas, Matthew Davidson, Parisa Zakavi, Naotsugu Tsuchiya, Jeroen van Boxtel
Motion Induced Blindness (MIB) is a well-established visual phenomenon whereby highly salient targets disappear when viewed against a moving background mask. No research has yet explored whether contracting and expanding optic flow can also trigger target disappearance. We explored MIB using mask speeds corresponding to driving at 35, 50, 65 and 80 km/h in simulated forward (expansion) and backward (contraction) motion as well as 2-D radial movement, random, and static mask motion types. Participants (n = 18) viewed MIB targets against masks with different movement types, speed, and target locations...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28825670/further-evidence-of-a-specific-psychopathology-of-addiction-differentiation-from-other-psychiatric-psychopathological-dimensions-such-as-obesity
#9
Angelo G I Maremmani, Luca Cerniglia, Silvia Cimino, Silvia Bacciardi, Luca Rovai, Alessandro Pallucchini, Vincenza Spera, Giulio Perugi, Icro Maremmani
Introduction: In this study, we used a symptomatology checklist (SCL-90) to substantiate the hypothesis that Substance Use Disorder (SUD) has its own five-dimensional psychopathology. The aim of the present study was to test whether this psychopathology can be differentiated from other psychiatric psychopathological dimensions (such as obesity). Methods: The severity and frequency of each of the five dimensions were investigated, at univariate and multivariate levels, by comparing 972 Heroin Use Disorder (HUD) patients (83...
August 21, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28739747/application-of-serum-elavl4-hud-antigen-assay-for-small-cell-lung-cancer-diagnosis
#10
Feifei Wang, Jianyi Lu, Shentao Li, Xueyun Huo, Xin Liu, Xiaoyan Du, Changlong Li, Jinghui Wang, Zhenwen Chen
BACKGROUND/AIM: The ELAVL4 (HuD) is a neuron-specific RNA-binding protein expressed in 100% of small cell lung cancer (SCLC) cells and over 50% of neuroblastoma cells. The aim of this study was to investigate the serum HuD concentration in SCLC patients and the possibility of its utilization as a biomarker of small cell lung cancer. MATERIALS AND METHODS: Our study included 47 SCLC cases and 29 normal controls. Indirect competitive inhibition ELISA method was established to detect HuD antigen of serum samples...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28704196/antioxidant-capacity-and-phenolic-content-of-two-algerian-mentha-species-m-rotundifolia-l-huds-m-pulegium-l-extracted-with-different-solvents
#11
Fatiha Brahmi, Farid Dahmoune, Nabil Kadri, Mohmed Chibane, Soufiane Dairi, Hocine Remini, Sonia Oukmanou-Bensidhoum, Lotfi Mouni, Khodir Madani
Background It is important to consider the optimum conditions and processing factors (like solvent type) influencing activity of plant antioxidants for utilization in food and biological systems. Methods The antioxidant capacity and phenolic content of two Mentha species, namely, Mentha pulegium L. (MP) and Mentha rotundifolia (L.) Huds (MR), were studied and six solvent systems were used. The total antioxidant capacity of the mint species extracts was evaluated using phosphomolybdenum method and the free radical-scavenging capacity by 2,2-diphenyl-1-picrylhydrazyl radical-scavenging assay...
July 8, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28661422/silicate-promoted-phosphorylation-of-glycerol-in-non-aqueous-solvents-a-prebiotically-plausible-route-to-organophosphates
#12
Maheen Gull, Brian J Cafferty, Nicholas V Hud, Matthew A Pasek
Phosphorylation reactions of glycerol were studied using different inorganic phosphates such as sodium phosphate, trimetaphosphate (a condensed phosphate), and struvite. The reactions were carried out in two non-aqueous solvents: formamide and a eutectic solvent consisting of choline-chloride and glycerol in a ratio of 1:2.5. The glycerol reacted in formamide and in the eutectic solvent with phosphate to yield its phosphorylated derivatives in the presence of silicates such as quartz sand and kaolinite clay...
June 29, 2017: Life
https://www.readbyqxmd.com/read/28635376/advances-in-understanding-the-role-of-disease-associated-proteins-in-spinal-muscular-atrophy
#13
Seyyedmohsen Hosseinibarkooie, Svenja Schneider, Brunhilde Wirth
Spinal muscular atrophy (SMA) is a neurodegenerative disorder characterized by alpha motor neuron loss in the spinal cord due to reduced survival motor neuron (SMN) protein level. While the genetic basis of SMA is well described, the specific molecular pathway underlying SMA is still not fully understood. Areas covered: This review discusses the recent advancements in understanding the molecular pathways in SMA using different omics approaches and genetic modifiers identified in both vertebrate and invertebrate systems...
June 30, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28591168/exploiting-repetitive-sequences-and-bac-clones-in-festuca-pratensis-karyotyping
#14
Joanna Majka, Tomasz Książczyk, Agnieszka Kiełbowicz-Matuk, David Kopecký, Arkadiusz Kosmala
The Festuca genus is thought to be the most numerous genus of the Poaceae family. One of the most agronomically important forage grasses, Festuca pratensis Huds. is treated as a model plant to study the molecular mechanisms associated with tolerance to winter stresses, including frost. However, the precise mapping of the genes governing stress tolerance in this species is difficult as its karyotype remains unrecognized. Only two F. pratensis chromosomes with 35S and 5S rDNA sequences can be easily identified, but its remaining chromosomes have not been distinguished to date...
2017: PloS One
https://www.readbyqxmd.com/read/28583959/hud-housing-assistance-associated-with-lower-uninsurance-rates-and-unmet-medical-need
#15
Alan E Simon, Andrew Fenelon, Veronica Helms, Patricia C Lloyd, Lauren M Rossen
To investigate whether receiving US Department of Housing and Urban Development (HUD) housing assistance is associated with improved access to health care, we analyzed data on nondisabled adults ages 18-64 who responded to the 2004-12 National Health Interview Survey that were linked with administrative data from HUD for the period 2002-14. To account for potential selection bias, we compared access to care between respondents who were receiving HUD housing assistance at the time of the survey interview (current recipients) and those who received HUD assistance within twenty-four months of completing the survey interview (future recipients)...
June 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28560387/reciprocal-antagonistic-regulation-of-n-myc-mrna-by-mir%C3%A2-17-and-the-neuronal-specific-rna-binding-protein-hud
#16
Leleesha Samaraweera, Barbara A Spengler, Robert A Ross
Neuroblastoma is a childhood cancer originating from embryonic neural crest cells. Amplification of the proto‑oncogene N-myc, seen in ~30% of neuroblastoma tumors, is a marker for poor prognosis. Recently discovered small regulatory RNAs, microRNAs (miRNAs), are implicated in cancers, including neuroblastoma. miRNAs downregulate the expression of genes by binding to the 3'-untranslated regions (3'-UTRs), thereby inhibiting translation or inducing degradation of cognate mRNAs. Our study sought to identify miRNAs that regulate N-myc expression and thereby malignancy in neuroblastoma...
July 2017: Oncology Reports
https://www.readbyqxmd.com/read/28542446/wheat-root-length-and-not-branching-is-altered-in-the-presence-of-neighbours-including-blackgrass
#17
Jessica A Finch, Gaëtan Guillaume, Stephanie A French, Renato D D R Colaço, Julia M Davies, Stéphanie M Swarbreck
The effect of neighbouring plants on crop root system architecture may directly interfere with water and nutrient acquisition, yet this important and interesting aspect of competition remains poorly understood. Here, the effect of the weed blackgrass (Alopecurus myosuroides Huds.) on wheat (Triticum aestivum L.) roots was tested, since a low density of this species (25 plants m-2) can lead to a 10% decrease in wheat yield and herbicide resistance is problematic. We used a simplified growth system based on gelled medium, to grow wheat alongside a neighbour, either another wheat plant, a blackgrass or Brachypodium dystachion individual (a model grass)...
2017: PloS One
https://www.readbyqxmd.com/read/28494392/opposed-effects-of-hyperthymic-and-cyclothymic-temperament-in-substance-use-disorder-heroin-or-alcohol-dependent-patients
#18
Luca Rovai, Angelo G I Maremmani, Silvia Bacciardi, Denise Gazzarrini, Alessandro Pallucchini, Vincenza Spera, Giulio Perugi, Icro Maremmani
INTRODUCTION: In the last decade, the comprehension of affective temperaments has helped us to outline the boundaries of mood disorders, and to expand our knowledge of nosographic areas other than those of affectivity, even if affectivity is closely related to them. In the field of substance use disorders, the temperamental profile of heroin addicts and alcoholics has been discussed elsewhere, but no comparison has yet been made between these two patient populations. Such a comparison would help to shed light on the pathogenetic mechanisms that link temperament with substance abuse...
April 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28481597/housing-first-on-a-large-scale-fidelity-strengths-and-challenges-in-the-va-s-hud-vash-program
#19
Stefan G Kertesz, Erika L Austin, Sally K Holmes, Aerin J DeRussy, Carol Van Deusen Lukas, David E Pollio
Housing First (HF) combines permanent supportive housing and supportive services for homeless individuals and removes traditional treatment-related preconditions for housing entry. There has been little research describing strengths and shortfalls of HF implementation outside of research demonstration projects. The U.S. Department of Veterans Affairs (VA) has transitioned to an HF approach in a supportive housing program serving over 85,000 persons. This offers a naturalistic window to study fidelity when HF is adopted on a large scale...
May 2017: Psychological Services
https://www.readbyqxmd.com/read/28427913/predicting-the-stone-composition-of-children-preoperatively-by-hounsfield-unit-detection-on-non-contrast-computed-tomography
#20
Mesut Altan, Burak Çitamak, Ali Cansu Bozaci, Altan Güneş, Hasan Serkan Doğan, Mithat Haliloğlu, Serdar Tekgül
INTRODUCTION: Many studies have been performed on adult patients to reveal the relationship between Hounsfield unit (HU) value and composition of stone, but none have focused on childhood. OBJECTIVE: We aimed to predict stone composition by HU properties in pre-intervention non-contrast computed tomography (NCCT) in children. This could help to orient patients towards more successful interventions. MATERIALS AND METHODS: Data of 94 children, whose pre-intervention NCCT and post-interventional stone analysis were available were included...
March 31, 2017: Journal of Pediatric Urology
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