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https://www.readbyqxmd.com/read/28635376/advances-in-understanding-the-role-of-disease-associated-proteins-in-spinal-muscular-atrophy
#1
Seyyedmohsen Hosseinibarkooie, Svenja Schneider, Brunhilde Wirth
Spinal muscular atrophy (SMA) is a neurodegenerative disorder characterized by alpha motor neuron loss in the spinal cord due to reduced survival of motor neuron (SMN) protein level. While the genetic basis of SMA is well described, the specific molecular pathway underlying SMA is still not fully understood. Areas covered: This review discusses the recent advancements in understanding the molecular pathways in SMA using different omics approaches and genetic modifiers identified in both vertebrate and invertebrate systems...
June 21, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28591168/exploiting-repetitive-sequences-and-bac-clones-in-festuca-pratensis-karyotyping
#2
Joanna Majka, Tomasz Książczyk, Agnieszka Kiełbowicz-Matuk, David Kopecký, Arkadiusz Kosmala
The Festuca genus is thought to be the most numerous genus of the Poaceae family. One of the most agronomically important forage grasses, Festuca pratensis Huds. is treated as a model plant to study the molecular mechanisms associated with tolerance to winter stresses, including frost. However, the precise mapping of the genes governing stress tolerance in this species is difficult as its karyotype remains unrecognized. Only two F. pratensis chromosomes with 35S and 5S rDNA sequences can be easily identified, but its remaining chromosomes have not been distinguished to date...
2017: PloS One
https://www.readbyqxmd.com/read/28583959/hud-housing-assistance-associated-with-lower-uninsurance-rates-and-unmet-medical-need
#3
Alan E Simon, Andrew Fenelon, Veronica Helms, Patricia C Lloyd, Lauren M Rossen
To investigate whether receiving US Department of Housing and Urban Development (HUD) housing assistance is associated with improved access to health care, we analyzed data on nondisabled adults ages 18-64 who responded to the 2004-12 National Health Interview Survey that were linked with administrative data from HUD for the period 2002-14. To account for potential selection bias, we compared access to care between respondents who were receiving HUD housing assistance at the time of the survey interview (current recipients) and those who received HUD assistance within twenty-four months of completing the survey interview (future recipients)...
June 1, 2017: Health Affairs
https://www.readbyqxmd.com/read/28560387/reciprocal-antagonistic-regulation-of-n-myc-mrna-by-mir%C3%A2-17-and-the-neuronal-specific-rna-binding-protein-hud
#4
Leleesha Samaraweera, Barbara A Spengler, Robert A Ross
Neuroblastoma is a childhood cancer originating from embryonic neural crest cells. Amplification of the proto‑oncogene N-myc, seen in ~30% of neuroblastoma tumors, is a marker for poor prognosis. Recently discovered small regulatory RNAs, microRNAs (miRNAs), are implicated in cancers, including neuroblastoma. miRNAs downregulate the expression of genes by binding to the 3'-untranslated regions (3'-UTRs), thereby inhibiting translation or inducing degradation of cognate mRNAs. Our study sought to identify miRNAs that regulate N-myc expression and thereby malignancy in neuroblastoma...
May 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28542446/wheat-root-length-and-not-branching-is-altered-in-the-presence-of-neighbours-including-blackgrass
#5
Jessica A Finch, Gaëtan Guillaume, Stephanie A French, Renato D D R Colaço, Julia M Davies, Stéphanie M Swarbreck
The effect of neighbouring plants on crop root system architecture may directly interfere with water and nutrient acquisition, yet this important and interesting aspect of competition remains poorly understood. Here, the effect of the weed blackgrass (Alopecurus myosuroides Huds.) on wheat (Triticum aestivum L.) roots was tested, since a low density of this species (25 plants m-2) can lead to a 10% decrease in wheat yield and herbicide resistance is problematic. We used a simplified growth system based on gelled medium, to grow wheat alongside a neighbour, either another wheat plant, a blackgrass or Brachypodium dystachion individual (a model grass)...
2017: PloS One
https://www.readbyqxmd.com/read/28494392/opposed-effects-of-hyperthymic-and-cyclothymic-temperament-in-substance-use-disorder-heroin-or-alcohol-dependent-patients
#6
Luca Rovai, Angelo G I Maremmani, Silvia Bacciardi, Denise Gazzarrini, Alessandro Pallucchini, Vincenza Spera, Giulio Perugi, Icro Maremmani
INTRODUCTION: In the last decade, the comprehension of affective temperaments has helped us to outline the boundaries of mood disorders, and to expand our knowledge of nosographic areas other than those of affectivity, even if affectivity is closely related to them. In the field of substance use disorders, the temperamental profile of heroin addicts and alcoholics has been discussed elsewhere, but no comparison has yet been made between these two patient populations. Such a comparison would help to shed light on the pathogenetic mechanisms that link temperament with substance abuse...
April 23, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28481597/housing-first-on-a-large-scale-fidelity-strengths-and-challenges-in-the-va-s-hud-vash-program
#7
Stefan G Kertesz, Erika L Austin, Sally K Holmes, Aerin J DeRussy, Carol Van Deusen Lukas, David E Pollio
Housing First (HF) combines permanent supportive housing and supportive services for homeless individuals and removes traditional treatment-related preconditions for housing entry. There has been little research describing strengths and shortfalls of HF implementation outside of research demonstration projects. The U.S. Department of Veterans Affairs (VA) has transitioned to an HF approach in a supportive housing program serving over 85,000 persons. This offers a naturalistic window to study fidelity when HF is adopted on a large scale...
May 2017: Psychological Services
https://www.readbyqxmd.com/read/28427913/predicting-the-stone-composition-of-children-preoperatively-by-hounsfield-unit-detection-on-non-contrast-computed-tomography
#8
Mesut Altan, Burak Çitamak, Ali Cansu Bozaci, Altan Güneş, Hasan Serkan Doğan, Mithat Haliloğlu, Serdar Tekgül
INTRODUCTION: Many studies have been performed on adult patients to reveal the relationship between Hounsfield unit (HU) value and composition of stone, but none have focused on childhood. OBJECTIVE: We aimed to predict stone composition by HU properties in pre-intervention non-contrast computed tomography (NCCT) in children. This could help to orient patients towards more successful interventions. MATERIALS AND METHODS: Data of 94 children, whose pre-intervention NCCT and post-interventional stone analysis were available were included...
March 31, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28389784/findings-from-the-initial-use-of-the-healthy-homes-rating-system-hhrs-in-three-american-cities
#9
Katelyn Burkart, Jonatan Martinez, Alicia Streater, Lyke Thompson
HUD's Healthy Homes Rating System (HHRS) is a modification of the English version, using scoring values developed in England. The goal of the HUD Three-City Healthy Homes Rating System (HHRS) study was to create a baseline of the prevalence and severity of 29 home health hazards in three cities-Detroit, MI; Greensboro, NC; and Alameda County, CA-and to compare the results to the prevalence and severity found in England. We analyzed 978 housing assessments over 3 years. Hygrothermal hazards (e.g., excess cold) were the most prevalent across the sites...
April 7, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28338690/a-viscous-solvent-enables-information-transfer-from-gene-length-nucleic-acids-in-a-model-prebiotic-replication-cycle
#10
Christine He, Isaac Gállego, Brandon Laughlin, Martha A Grover, Nicholas V Hud
Many hypotheses concerning the nature of early life assume that genetic information was once transferred through the template-directed synthesis of RNA, before the emergence of coded enzymes. However, attempts to demonstrate enzyme-free, template-directed synthesis of nucleic acids have been limited by 'strand inhibition', whereby transferring information from a template strand in the presence of its complementary strand is inhibited by the stability of the template duplex. Here, we use solvent viscosity to circumvent strand inhibition, demonstrating information transfer from a gene-length template (>300 nt) within a longer (545 bp or 3 kb) duplex...
April 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28334877/iron-mediates-catalysis-of-nucleic-acid-processing-enzymes-support-for-fe-ii-as-a-cofactor-before-the-great-oxidation-event
#11
C Denise Okafor, Kathryn A Lanier, Anton S Petrov, Shreyas S Athavale, Jessica C Bowman, Nicholas V Hud, Loren Dean Williams
Life originated in an anoxic, Fe2+-rich environment. We hypothesize that on early Earth, Fe2+ was a ubiquitous cofactor for nucleic acids, with roles in RNA folding and catalysis as well as in processing of nucleic acids by protein enzymes. In this model, Mg2+ replaced Fe2+ as the primary cofactor for nucleic acids in parallel with known metal substitutions of metalloproteins, driven by the Great Oxidation Event. To test predictions of this model, we assay the ability of nucleic acid processing enzymes, including a DNA polymerase, an RNA polymerase and a DNA ligase, to use Fe2+ in place of Mg2+ as a cofactor during catalysis...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334706/repetitive-dna-a-versatile-tool-for-karyotyping-in-festuca-pratensis-huds
#12
Anna Křivánková, David Kopecký, Štěpán Stočes, Jaroslav Doležel, Eva Hřibová
FISH is a useful method to identify individual chromosomes in a karyotype and to discover their structural changes accompanying genome evolution and speciation. DNA probes for FISH should be chromosome specific and/or exhibit specific patterns of distribution along each chromosome. Such probes are not available in many plants including meadow fescue (Festuca pratensis Huds.), an important forage grass species. In the present study, various DNA repeats identified in Illumina shotgun sequences specific to chromosome 4F of F...
2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28207335/housing-assistance-programs-and-adult-health-in-the-united-states
#13
Andrew Fenelon, Patrick Mayne, Alan E Simon, Lauren M Rossen, Veronica Helms, Patricia Lloyd, Jon Sperling, Barry L Steffen
OBJECTIVES: To examine whether access to housing assistance is associated with better health among low-income adults. METHODS: We used National Health Interview Survey data (1999-2012) linked to US Department of Housing and Urban Development (HUD) administrative records (1999-2014) to examine differences in reported fair or poor health and psychological distress. We used multivariable models to compare those currently receiving HUD housing assistance (public housing, housing choice vouchers, and multifamily housing) with those who will receive housing assistance within 2 years (the average duration of HUD waitlists) to account for selection into HUD assistance...
April 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28192095/cigarette-smoking-and-adverse-health-outcomes-among-adults-receiving-federal-housing-assistance
#14
Veronica E Helms, Brian A King, Peter J Ashley
Cigarette smoking is higher among low-income adults and individuals who reside in federally assisted housing are particularly susceptible to the adverse effects of smoking and secondhand smoke exposure. This study assessed smoking-related behaviors and health outcomes among U.S. adults who received federal housing assistance during 2006-2012. National Health Interview Survey data linked with administrative data from the U.S. Department of Housing and Urban Development were analyzed; 5218 HUD-assisted adults were assessed...
February 10, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28186420/driving-while-interacting-with-google-glass-investigating-the-combined-effect-of-head-up-display-and-hands-free-input-on-driving-safety-and-multitask-performance
#15
Kathryn G Tippey, Elayaraj Sivaraj, Thomas K Ferris
OBJECTIVE: This study evaluated the individual and combined effects of voice (vs. manual) input and head-up (vs. head-down) display in a driving and device interaction task. BACKGROUND: Advances in wearable technology offer new possibilities for in-vehicle interaction but also present new challenges for managing driver attention and regulating device usage in vehicles. This research investigated how driving performance is affected by interface characteristics of devices used for concurrent secondary tasks...
June 2017: Human Factors
https://www.readbyqxmd.com/read/28182604/announcement-federally-assisted-housing-standards-for-blood-lead-levels-aligned-with-cdc-recommended-threshold
#16
(no author information available yet)
On January 13, 2017, the U.S. Department of Housing and Urban Development (HUD) lowered the threshold of lead in young children's blood that triggers interventions to evaluate and control exposure hazards from 20 μg/dL to 5 μg/dL, matching the reference level used by CDC (1). The rule includes a process to continue HUD alignment with any future updates to CDC's reference level (1).
February 10, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28150176/health-hazards-in-the-home-an-assessment-of-a-southern-nevada-community
#17
Amanda Sokolowsky, Erika Marquez, Erin Sheehy, Casey Barber, Shawn Gerstenberger
As a sub-grantee of a Department of Housing and Urban Development (HUD) Lead Hazard Control and Healthy Homes Program, the University of Nevada, Las Vegas' Department of Environmental and Occupational Health performed lead and Healthy Homes investigations and collected data regarding conditions in the home environment in Henderson, Nevada. The purpose of this research is to characterize housing conditions in southern Nevada, compare data to census data, and to highlight the health outcomes associated with adverse housing conditions...
February 1, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28113076/expression-of-flhma3-a-p1b2-atpase-from-festulolium-loliaceum-correlates-with-response-to-cadmium-stress
#18
Qiang Guo, Lin Meng, Mike W Humphreys, John Scullion, Luis A J Mur
Heavy metal ATPase 3 (HMA3), a P1B2-ATPase, is a key tonoplast transporter involved in mediating the vacuolar sequestration of cadmium (Cd) to detoxify the intake of this element by plants. HMA3 expression in response to Cd stress has not been previously examined in the grass hybrid species Festulolium loliaceum (Huds.) P. Fourn. In this study, FlHMA3 isolated from F. loliaceum was found to comprise 833 amino acid residues with 77% homology to the rice OsHMA3. Transient expression of FlHMA3 fused to enhanced green fluorescent protein in Arabidopsis protoplasts suggested its localization to vacuolar membranes...
March 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28111162/hud-mediated-distinct-bdnf-regulatory-pathways-promote-regeneration-after-nerve-injury
#19
Maria Domenica Sanna, Carla Ghelardini, Nicoletta Galeotti
Up-regulation of brain-derived neurotrophic factor (BDNF)synthesis is an important mechanism of peripheralnerveregenerationafterinjury.However, the cellular and molecular mechanisms underlying this process are not fully understood. This study examines the role of BDNF in the spared nerve injury (SNI) mice model. Protein expression and cellular localization were investigated in the dorsal root ganglia (DRG) and spinal cord by western blotting and immunofluorescence experiments respectively. BDNF protein was markedly increased 3 and 7 days post-injury in the spinal cord and DRG...
January 19, 2017: Brain Research
https://www.readbyqxmd.com/read/28108383/traditional-uses-of-medicinal-plants-reported-by-the-indigenous-communities-and-local-herbal-practitioners-of-bajaur-agency-federally-administrated-tribal-areas-pakistan
#20
Muhammad Abdul Aziz, Amir Hasan Khan, Muhammad Adnan, Izatullah Izatullah
ETHNOPHARMACOLOGICAL RELEVANCE: In the study area, knowledge related to the traditional uses of medicinal plants is totally in the custody of elder community members and local herbalists. The younger generation is unaware of the traditional knowledge, however with only few exceptions. Therefore, this study was planned with objective to document the medicinal importance of plants, conserve this precious indigenous knowledge, and share it among other communities through published literature...
January 17, 2017: Journal of Ethnopharmacology
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