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https://www.readbyqxmd.com/read/29626565/antidepressant-like-actions-by-silencing-of-neuronal-elav-like-rna-binding-proteins-hub-and-huc-in-a-model-of-depression-in-male-mice
#1
Maria Domenica Sanna, Alessandro Quattrone, Nicoletta Galeotti
Currently available antidepressant drugs often fail to achieve full remission and patients might evolve to treatment resistance, showing the need to achieve a better therapy of depressive disorders. Increasing evidence supports that post-transcriptional regulation of gene expression is important in neuronal development and survival and a relevant role is played by RNA binding proteins (RBP). To explore new therapeutic strategies, we investigated the role of the neuron-specific ELAV-like RBP (HuB, HuC, HuD) in a mouse model of depression...
April 4, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29590218/interaction-of-huda-and-pabp-at-5-utr-of-mouse-insulin2-regulates-insulin-biosynthesis
#2
Poonam R Pandey, Rucha D Sarwade, Abdul Khalique, Vasudevan Seshadri
Understanding the regulation of insulin biosynthesis is important as it plays a central role in glucose metabolism. The mouse insulin gene2 (Ins2) has two splice variants; long (Ins2L) and short (Ins2S), that differ only in their 5'UTR sequence and Ins2S is the major transcript which translate more efficiently as compared to Ins2L. Here, we show that cellular factors bind preferentially to the Ins2L 5'UTR, and that PABP and HuD can bind to Ins2 splice variants and regulate its translation. In vitro binding assay with insulin 5'UTR and different HuD isoforms indicate that the 'N' terminal region of HuD is important for RNA binding and insulin translation repression...
2018: PloS One
https://www.readbyqxmd.com/read/29565788/characteristics-and-correlates-of-cigarette-smoking-status-among-us-adults-receiving-federal-housing-assistance
#3
Teresa W Wang, Veronica E Helms, Peter J Ashley, Brian A King
This study describes patterns of cigarette smoking (current, former, never) by sociodemographic, household, and chronic disease characteristics and correlates among US adults receiving housing assistance from the US Department of Housing and Urban Development (HUD) during 2007-2012. Estimates were generated from 4,771 adults by using National Health Interview Survey and HUD-linked data. Overall, 48.4% of HUD-assisted adults were never smokers, 33.0% were current smokers, and 18.6% were former smokers; smoking status varied by sex, age, race/ethnicity, whether children were living in the household, and chronic disease status...
March 22, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29543169/driver-behavior-and-performance-with-augmented-reality-pedestrian-collision-warning-an-outdoor-user-study
#4
Hyungil Kim, Joseph L Gabbard, Alexandre Miranda Anon, Teruhisa Misu
This article investigates the effects of visual warning presentation methods on human performance in augmented reality (AR) driving. An experimental user study was conducted in a parking lot where participants drove a test vehicle while braking for any cross traffic with assistance from AR visual warnings presented on a monoscopic and volumetric head-up display (HUD). Results showed that monoscopic displays can be as effective as volumetric displays for human performance in AR braking tasks. The experiment also demonstrated the benefits of conformal graphics, which are tightly integrated into the real world, such as their ability to guide drivers' attention and their positive consequences on driver behavior and performance...
April 2018: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/29523802/polygonumins-a-a-newly-isolated-compound-from-the-stem-of-polygonum-minus-huds-with-potential-medicinal-activities
#5
Rafidah Ahmad, I Sahidin, Muhammad Taher, ChenFei Low, Normah Mohd Noor, Chanin Sillapachaiyaporn, Siriporn Chuchawankul, Tewarit Sarachana, Tewin Tencomnao, Faizah Iskandar, Nor Fadilah Rajab, Syarul Nataqain Baharum
Polygonumins A, a new compound, was isolated from the stem of Polygonum minus. Based on NMR results, the compound's structure is identical to that of vanicoside A, comprising four phenylpropanoid ester units and a sucrose unit. The structure differences were located at C-3″″'. The cytotoxic activity of polygonumins A was evaluated on several cancer cell lines by a cell viability assay using tetrazolium dye 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). The compound showed the highest antiproliferative (p < 0...
March 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29493811/how-do-housing-subsidies-improve-quality-of-life-among-homeless-adults-a-mediation-analysis
#6
Maria O'Connell, Kyaw Sint, Robert Rosenheck
Supported housing, combining rent subsidies with intensive case management, is associated with improvements in quality of life of homeless adults, but factors mediating their impact on quality of life have not been studied. Twelve-month outcome data from a randomized trial of the Housing and Urban Development- Veterans Affairs Supported Housing program (HUD-VASH) showed that access to a housing rent subsidy plus intensive case management (ICM) was associated with greater improvement in subjective quality of life than ICM alone...
March 1, 2018: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29482457/barriers-and-facilitators-to-housing-access-and-maintenance-in-hud-vash-participant-and-staff-perspectives
#7
Meagan Cusack, Ann Elizabeth Montgomery
Though the U.S. Departments of Housing and Urban Development (HUD) and Veterans Affairs (VA) supportive housing (HUD-VASH) program endeavors to address barriers to Veterans accessing and maintaining housing, participants report challenges that lead to program exits. This study aims to understand participants' views on the factors contributing to their exits from HUD-VASH, as well as how program staff may respond to challenges. This mixed methods study includes four sources of data: (1) surveys with Veterans, (2) semi-structured interviews with a subsample of surveyed Veterans, (3) Veterans' administrative data from VA electronic data systems, and (4) focus groups with staff from local public housing authorities and VA case management teams...
February 26, 2018: Social Work in Health Care
https://www.readbyqxmd.com/read/29446872/does-selective-hormesis-impact-herbicide-resistance-evolution-in-weeds-accase-resistant-populations-of-alopecurus-myosuroides-huds-as-a-case-study
#8
Regina G Belz, Muhammad B Farooq, Jean Wagner
BACKGROUND: A field-evolved herbicide-resistant weed population can represent a heterogeneous composite of subpopulations that differ in their susceptibility and responsiveness to herbicide hormesis. Variable hormesis responsiveness can result in selection for and against certain subpopulations under low herbicide doses, and this has the potential to contribute to the evolution of resistance. The relevance of this hypothesis at practical field rates was studied for two field-collected acetyl-coenzyme A carboxylase (ACCase) target-site resistant (TSR) biotypes of Alopecurus myosuroides Huds...
February 15, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29376849/progression-of-alzheimer-s-disease-related-pathology-and-cell-counts-in-a-patient-with-idiopathic-normal-pressure-hydrocephalus
#9
Sylwia Libard, Katarina Laurell, Kristina Giuliana Cesarini, Irina Alafuzoff
We had an opportunity to assess the change observed in the brain regarding Alzheimer's disease (AD)-related alterations, cell count, and inflammation that took place during a period of 21 months in a subject with a definite diagnosis of AD and idiopathic Normal Pressure Hydrocephalus (iNPH). Four neuronal markers, i.e., synaptophysin, microtubule associated protein 2, non-phosphorylated neurofilament H (SMI32), and embryonic lethal abnormal visual system proteins 3/4 HuC/HuD (HuC/HuD); three microglial markers CD68, Human Leucocytic Antigen DR, ionized calcium-binding adaptor molecule 1, glial fibrillary acidic protein (GFAP); and AD-related markers, hyperphosphorylated τ (HPτ) and amyloid-β (Aβ, Aβ40, Aβ42) were assessed...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29371875/psychopathology-of-addiction-can-the-scl90-based-five-dimensional-structure-differentiate-heroin-use-disorder-from-a-non-substance-related-addictive-disorder-such-as-gambling-disorder
#10
Angelo G I Maremmani, Denise Gazzarrini, Amelia Fiorin, Valeria Cingano, Graziano Bellio, Giulio Perugi, Icro Maremmani
Background: In the Gambling Disorder (GD), there is no exogenous drug administration that acts as the central core of the traditional meaning of addiction. A specific psychopathology of Substance Use Disorders has been proposed recently. In a sample of Heroin Use Disorder (HUD) patients entering opioid agonist treatment, it became possible to identify a group of 5 mutually exclusive psychiatric dimensions: Worthlessness-Being trapped (W-BT), Somatic Symptoms (SS), Sensitivity-Psychoticism (SP), Panic Anxiety (PA) and Violence-Suicide (VS)...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29325493/simulation-based-evaluation-of-an-in-vehicle-smart-situation-awareness-enhancement-system
#11
Andreas Gregoriades, Alistair Sutcliffe
Situation awareness (SA) constitutes a critical factor in road safety, strongly related to accidents. This paper describes the evaluation of a proposed SA enhancement system (SAES) that exploits augmented reality through a head-up display (HUD). Two SAES designs were evaluation (information rich vs. minimal information) using a custom-made simulator and the Situation Awareness Global Assessment Technique with performance and EEG measures. The paper describes the process of assessing the SA of drivers using the SAES, through a series of experiments with participants in a Cave Automatic Virtual Environment...
February 7, 2018: Ergonomics
https://www.readbyqxmd.com/read/29321433/a-case-of-cv2-crmp5-antibody-related-paraneoplastic-optic-neuropathy-associated-with-small-cell-lung-cancer
#12
Masanori Nakajima, Ayumi Uchibori, Yuki Ogawa, Tai Miyazaki, Yaeko Ichikawa, Kimihiko Kaneko, Toshiyuki Takahashi, Ichiro Nakashima, Hirokazu Shiraishi, Masakatsu Motomura, Atsuro Chiba
A 61-year-old woman who had smoked for 40 years developed subacute dizziness, ataxic gait, opsoclonus, and right visual impairment. She had right optic disc swelling and optic nerve gadolinium enhancement on magnetic resonance imaging. She had small-cell lung cancer (SCLC), with CV2/collapsin response mediator protein (CRMP) 5 and HuD antibodies in her serum and cerebrospinal fluid. She was diagnosed with paraneoplastic optic neuropathy (PON) accompanied by paraneoplastic opsoclonus-ataxia syndrome. Her symptoms improved after removing the SCLC...
January 11, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29283498/neuronal-rna-binding-protein-hud-regulates-addiction-related-gene-expression-and-behavior
#13
R J Oliver, J L Brigman, F Bolognani, A M Allan, J L Neisewander, N I Perrone-Bizzozero
The neuronal RNA-binding protein HuD is involved in synaptic plasticity and learning and memory mechanisms. These effects are thought to be due to HuD-mediated stabilization and translation of target mRNAs associated with plasticity. To investigate the potential role of HuD in drug addiction, we first used bioinformatics prediction algorithms together with microarray analyses to search for specific genes and functional networks upregulated within the forebrain of HuD overexpressing mice (HuDOE ). When this set was further limited to genes in the knowledgebase of addiction-related genes database (KARG) that contains predicted HuD-binding sites in their 3' untranslated regions (3'UTRs), we found that HuD regulates networks that have been associated with addiction-like behavior...
December 28, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29277384/effectiveness-of-visual-warnings-on-young-drivers-hazard-anticipation-and-hazard-mitigation-abilities
#14
Foroogh Hajiseyedjavadi, Tingru Zhang, Ravi Agrawal, Michael Knodler, Donald Fisher, Siby Samuel
Previous studies have demonstrated that young drivers fail both to scan for and mitigate latent hazards mostly due to their cluelessness. This study aims to investigate whether these skills could be improved by providing young drivers with alerts in advance of the upcoming threat using a driving simulator experiment. In particular, the warning was presented on the head-up displays (HUD) either 2 s, 3 s or 4 s in advance of a latent threat. The hazard anticipation, hazard mitigation and attention maintenance performance of forty-eight young drivers aged 18-25 was evaluated across eight unique scenarios either in the presence or in the absence of latent threat alerts displayed on a HUD...
December 22, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29234334/no-vegetative-and-fecundity-fitness-cost-associated-with-acetyl-coenzyme-a-carboxylase-non-target-site-resistance-in-a-black-grass-alopecurus-myosuroides-huds-population
#15
Eshagh Keshtkar, Solvejg K Mathiassen, Per Kudsk
Attention should be devoted to weeds evolving herbicide resistance with non-target-site resistance (NTSR) mechanism due to their unpredictable resistance patterns. Quantification of fitness cost can be used in NTSR management strategies to determine the long-term fate of resistant plants in weed populations. To our knowledge, this is the first report evaluating potential fecundity and vegetative fitness of a NTSR black-grass ( Alopecurus myosuroides Huds), the most important herbicide resistant weed in Europe, with controlled genetic background...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29214572/incentivizing-orphan-product-development-united-states-food-and-drug-administration-orphan-incentive-programs
#16
Tran T Le
Over 30 years ago, the United States (US) Congress passed the Orphan Drug Act (ODA) to encourage the development of products for rare diseases or conditions ("orphan products"). The Act provided incentives to sponsors for developing products with orphan designation and established a grant program to fund studies of orphan products. Since its enactment in 1983, the ODA has been credited for bringing more than 590 orphan drugs to the market, inspiring the implementation of orphan legislation globally, and enabling the creation of other programs that extend existing knowledge of the natural history of rare diseases and stimulate the development of medical devices for children and patients with rare diseases...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29206624/use-of-highways-in-the-sky-and-a-virtual-pad-for-landing-head-up-display-symbology-to-enable-improved-helicopter-pilots-situation-awareness-and-workload-in-degraded-visual-conditions
#17
Neville A Stanton, Katherine L Plant, Aaron P Roberts, Craig K Allison
Flight within degraded visual conditions is a great challenge to pilots of rotary-wing craft. Environmental cues typically used to guide interpretation of speed, location and approach can become obscured, forcing the pilots to rely on data available from in-cockpit instrumentation. To ease the task of flight during degraded visual conditions, pilots require easy access to flight critical information. The current study examined the effect of 'Highways in the Sky' symbology and a conformal virtual pad for landing presented using a Head Up Display (HUD) on pilots' workload and situation awareness for both clear and degraded conditions across a series of simulated rotary-wing approach and landings...
December 15, 2017: Ergonomics
https://www.readbyqxmd.com/read/29192858/head-up-display-may-facilitate-safe-keyhole-surgery-for-cerebral-aneurysm-clipping
#18
Terushige Toyooka, Naoki Otani, Kojiro Wada, Arata Tomiyama, Satoru Takeuchi, Kazuya Fujii, Kosuke Kumagai, Takashi Fujii, Kentaro Mori
OBJECTIVE The head-up display (HUD) is a modern technology that projects images or numeric information directly into the observer's sight line. Surgeons will no longer need to look away from the surgical view using the HUD system to confirm the preoperative or navigation image. The present study investigated the usefulness of the HUD system for performing cerebral aneurysm clipping surgeries. METHODS Thirty-five patients underwent clipping surgery, including 20 keyhole surgeries for unruptured cerebral aneurysm, using the HUD system...
December 1, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29168866/chemical-composition-and-bioactive-properties-of-the-wild-mushroom-polyporus-squamosus-huds-fr-a-study-with-samples-from-romania
#19
Andrei Mocan, Ângela Fernandes, Lillian Barros, Gianina Crişan, Marija Smiljković, Marina Soković, Isabel C F R Ferreira
In Eastern Europe, wild mushrooms are widely collected in mountain areas and used for their medicinal properties or as healthy foods. This study aimed at determining the chemical composition (nutritional value, free sugars, organic acids, phenolic compounds, fatty acids and tocopherols) and bioactive properties (antioxidant, antimicrobial and antiquorum sensing) of wild Polyporus squamosus (Huds.) Fr from Romania. The results indicate that the fruiting bodies of P. squamosus are rich in carbohydrates (74.22 g per 100 g dw) and proteins (18...
January 24, 2018: Food & Function
https://www.readbyqxmd.com/read/29161650/how-the-morphological-properties-of-mentha-longifolia-l-huds-may-be-affected-by-geographical-differences
#20
Mohammad Mohammadi, Hossein Ali Asadi-Gharneh
With respect to the benefits of medicinal plants for human health and their use as food, they are extensively being researched and planted in different parts of the world including Iran. Among the most important parameters, which may affect the growth and the yield of medicinal plants is their geographical (ecotype) properties. Accordingly, a research work was proposed to investigate the effects of 10 different regions or ecotypes on the morphological properties of pennyroyal [Mentha longifolia. (L.) Huds.] from the Lamiaceae family in one of the Iranian provinces, namely Ilam...
January 2018: Journal of Photochemistry and Photobiology. B, Biology
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