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Maria J O'Connell, Wesley J Kasprow, Robert A Rosenheck
OBJECTIVE: This study examined social network structure and function among a sample of 460 homeless veterans who participated in an experimental trial of the Housing and Urban Development-Veterans Affairs Supported Housing (HUD-VASH) program. METHODS: Participants were randomly assigned to HUD-VASH (housing subsidies and case management), case management only, or standard care. Mixed-model longitudinal analysis was used to compare treatment groups on social network outcomes over 18 months...
October 17, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
Mario A Pulido, Meleeneh Kazarian DerHartunian, Zhenxia Qin, Eric M Chung, Diane S Kang, Andrew W Woodham, Jeffrey A Tsou, Rinse Klooster, Omid Akbari, Lina Wang, W Martin Kast, Stephen V Liu, Jan J G M Verschuuren, Dana W Aswad, Ite A Laird-Offringa
Autoantibodies against SCLC-associated neuronal antigen ELAVL4 (HuD) have been linked to smaller tumors and improved survival, but the antigenic epitope and mechanism of autoimmunity have never been solved. We report that recombinant human ELAVL4 protein incubated under physiological conditions acquires isoaspartylation, a type of immunogenic protein damage. Specifically, the N-terminal region of ELAVL4, previously implicated in SCLC-associated autoimmunity, undergoes isoaspartylation in vitro, is recognized by sera from anti-ELAVL4 positive SCLC patients and is highly immunogenic in subcutaneously injected mice and in vitro stimulated human lymphocytes...
October 15, 2016: Journal of Neuroimmunology
Sheng-Sheng Yu, Ramanarayanan Krishnamurthy, Facundo M Fernández, Nicholas V Hud, F Joseph Schork, Martha A Grover
In this work, we introduce a kinetic model to study the effectiveness of ester-mediated amide bond formation under prebiotic conditions. In our previous work, we found that a simple system composed of α-hydroxy acids and α-amino acids is capable of forming peptide bonds via esterification followed by the ester-amide exchange reaction. To further understand the kinetic behavior of this copolymerization, we first tracked the growth of initial species from a valine/lactic acid mixture in a closed system reactor...
October 3, 2016: Physical Chemistry Chemical Physics: PCCP
Jesse V Gavette, Matthias Stoop, Nicholas V Hud, Ramanarayanan Krishnamurthy
The RNA world hypothesis posits that DNA and proteins were later inventions of early life, or the chemistry that gave rise to life. Most scenarios put forth for the emergence of DNA assume a clean separation of RNA and DNA polymer, and a smooth transition between RNA and DNA. However, based on the reality of "clutter" and lack of sophisticated separation/discrimination mechanisms in a protobiological (and/or prebiological) world, heterogeneous RNA-DNA backbone containing chimeric sequences could have been common-and have not been fully considered in models transitioning from an RNA world to an RNA-DNA world...
October 10, 2016: Angewandte Chemie
Katherine A Ahrens, Barbara A Haley, Lauren M Rossen, Patricia C Lloyd, Yutaka Aoki
OBJECTIVES: To compare blood lead levels (BLLs) among US children aged 1 to 5 years according to receipt of federal housing assistance. METHODS: In our analyses, we used 2005 to 2012 data for National Health and Nutrition Examination Survey (NHANES) respondents that were linked to 1999 to 2014 administrative records from the US Department of Housing and Urban Development (HUD). After we restricted the analysis to children with family income-to-poverty ratios below 200%, we compared geometric mean BLLs and the prevalence of BLLs of 3 micrograms per deciliter or higher among children who were living in assisted housing at the time of their NHANES blood draw (n = 151) with data for children who did not receive housing assistance (n = 1099)...
November 2016: American Journal of Public Health
Nadège Oustriere, Lilian Marchand, Jean Luc Bouchardon, Olivier Faure, Jacques Moutte, Michel Mench
Aided phytostabilization of a barren, alkaline metal(loid)-contaminated technosol developed on steel mill wastes, with high soluble Cr and Mo concentrations, was assessed in a pot experiment using (1) Ni/Cd-tolerant populations of Festuca pratensis Huds., Holcus lanatus L., and Plantago lanceolata L. sowed in mixed stand and (2) six soil treatments: untreated soil (UNT), ramial chipped wood (RCW, 500m(3)ha(-1)), composted sewage sludge (CSS, 120t DW ha(-1)), UNT soil amended with compost (5% w/w) and either vermiculite (5%, VOM) or iron grit (1%, OMZ), and an uncontaminated soil (CTRL)...
December 15, 2016: Journal of Hazardous Materials
Bradley Burcar, Matthew Pasek, Maheen Gull, Brian J Cafferty, Francisco Velasco, Nicholas V Hud, César Menor-Salván
The poor reactivity of insoluble phosphates, such as apatite-group minerals, has been a long-appreciated obstacle for proposed models of prebiotic organophosphate formation. This obstacle presents a significant challenge to the nascent development of an RNA world and other models for the origins of life on Earth. Herein, we demonstrate that a scenario based on the formation of a urea/ammonium formate/water (UAFW) eutectic solution leads to an increase in phosphorylation when compared to urea alone for phosphate sources of varying solubility...
October 10, 2016: Angewandte Chemie
Barbara L Brush, Laura E Gultekin, Elizabeth C Grim
Current estimates of homelessness in the U.S. are biased toward counts of sheltered or visibly unsheltered individuals. Those who remain out of sight during counts and/or live in places or circumstances that elude the United States Department of Housing and Urban Development's (HUD) definition of homelessness remain undercounted. Underreporting the unique characteristics associated with subgroups of people experiencing homelessness also limits access to the services that best meet their needs. As national counts drive policy and funding for housing-related services, front-line providers have too few resources to treat less visible and understood populations...
2016: Journal of Health Care for the Poor and Underserved
Nicoletta Marchesi, Marialaura Amadio, Claudia Colombrita, Stefano Govoni, Antonia Ratti, Alessia Pascale
Neuronal ELAV/Hu (nELAV) are RNA-binding proteins that mainly regulate gene expression by increasing the stability and/or translation rate of target mRNAs bearing ARE (adenine and uracil-rich elements) sequences. Among nELAV target transcripts there is ADAM10, an α-secretase involved in the non-amyloidogenic processing of the amyloid-β protein precursor (AβPP) which leads to the production of the neuroprotective sAβPPα peptide. The aim of this study was to evaluate if nELAV depletion affects ADAM10 expression in human SH-SY5Y neuroblastoma cells...
September 6, 2016: Journal of Alzheimer's Disease: JAD
Haihui Wang, Fika Tri Anggraini, Xuequn Chen, Donald J DeGracia
Prolonged translation arrest correlates with delayed neuronal death of hippocampal CA1 neurons following global cerebral ischemia and reperfusion. Many previous studies investigated ribosome molecular biology, but mRNA regulatory mechanisms after brain ischemia have been less studied. Here we investigated the embryonic lethal abnormal vision/Hu isoforms HuR, HuB, HuC, and HuD, as well as expression of mRNAs containing adenine and rich uridine elements following global ischemia in rat brain. Proteomics of embryonic lethal abnormal vision immunoprecipitations or polysomes isolated from rat hippocampal CA1 and CA3 from controls or following 10 min ischemia plus 8 h of reperfusion showed distinct sets of mRNA-binding proteins, suggesting differential mRNA regulation in each condition...
July 5, 2016: Journal of Cerebral Blood Flow and Metabolism
(no author information available yet)
On July 31, 2012, HUD published an interim rule entitled "Homeless Emergency Assistance and Rapid Transition to Housing: Continuum of Care Program." The Continuum of Care (CoC) program is designed to address the critical problem of homelessness through a coordinated community-based process of identifying needs and building a system of housing and services to address those needs. This rule amends the CoC program regulations to allow individuals and families to choose housing outside of a CoC's geographic area, subject to certain conditions, and to retain the tenant-based rental assistance under the CoC program...
June 14, 2016: Federal Register
C Li, B J Cafferty, S C Karunakaran, G B Schuster, N V Hud
The free nucleobases and mononucleotides of RNA do not form Watson-Crick base pairs in water, a fact that presents several challenges for the prebiotic synthesis of RNA. 2,6-Diaminopurine and adenosine-5'-monophosphate (AMP) are shown to form supramolecular assemblies with cyanuric acid in water. These assemblies and their propensity to form liquid crystals suggest a possible means by which non-covalent structures might have originally selected the shape of the Watson-Crick base pairs.
July 27, 2016: Physical Chemistry Chemical Physics: PCCP
M D Sanna, D Peroni, T Mello, C Ghelardini, A Quattrone, N Galeotti
Nucleoside reverse transcriptase inhibitors (NRTIs) are key components of HIV/AIDS treatment to reduce viral load. However, antiretroviral toxic neuropathy has become a common peripheral neuropathy among HIV/AIDS patients leading to discontinuation of antiretroviral therapy, for which the underlying pathogenesis is uncertain. This study examines the role of neurofilament (NF) proteins in the spinal dorsal horn, DRG and sciatic nerve after NRTI neurotoxicity in mice treated with zalcitabine (2',3'-dideoxycitidine; ddC)...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Liangbo Shen, Oscar Carrasco-Zevallos, Brenton Keller, Christian Viehland, Gar Waterman, Paul S Hahn, Anthony N Kuo, Cynthia A Toth, Joseph A Izatt
Intra-operative optical coherence tomography (OCT) requires a display technology which allows surgeons to visualize OCT data without disrupting surgery. Previous research and commercial intrasurgical OCT systems have integrated heads-up display (HUD) systems into surgical microscopes to provide monoscopic viewing of OCT data through one microscope ocular. To take full advantage of our previously reported real-time volumetric microscope-integrated OCT (4D MIOCT) system, we describe a stereoscopic HUD which projects a stereo pair of OCT volume renderings into both oculars simultaneously...
May 1, 2016: Biomedical Optics Express
Rebecca L Robinson, Michael Grabner, Swetha Rao Palli, Douglas Faries, Judith J Stephenson
OBJECTIVE: To characterize healthcare costs, resource use, and treatment patterns of survey respondents with a history of depression who are high utilizers (HUds) of healthcare and to identify factors associated with high utilization. METHODS: Adults with two or more depression diagnoses identified from the HealthCore Integrated Research Database were invited to participate in the CODE study, which links survey data with 12-month retrospective claims data. Patient surveys provided data on demographics, general health, and symptoms and/or comorbidities associated with depression...
June 2016: Journal of Psychosomatic Research
F Giancola, F Fracassi, A Gallucci, J Sadeghinezhad, G Polidoro, E Zini, M Asti, R Chiocchetti
Diabetes mellitus (DM) determines a wide array of severe clinical complications including gastrointestinal motility disorders. The present study investigates the effects of spontaneous DM on the intramural innervation and in particular on nitrergic neurons of the myenteric plexus (MP) of the canine gastric antrum and ileum. Specimens of antrum and ileum from eight control-dogs and five insulin-dependent DM-dogs were collected. MP neurons were immunohistochemically identified with the anti-HuC/HuD antibody, while nitrergic neurons were identified with the antibody anti-neuronal nitric oxide synthase (nNOS)...
May 2016: Autonomic Neuroscience: Basic & Clinical
Pier Paolo Pani, Angelo G I Maremmani, Emanuela Trogu, Federica Vigna-Taglianti, Federica Mathis, Roberto Diecidue, Ursula Kirchmayer, Laura Amato, Joli Ghibaudi, Antonella Camposeragna, Alessio Saponaro, Marina Davoli, Fabrizio Faggiano, Icro Maremmani
BACKGROUND: We previously found a five cluster of psychological symptoms in heroin use disorder (HUD) patients: 'worthlessness-being trapped', 'somatic-symptoms', 'sensitivity-psychoticism', 'panic-anxiety', and 'violence-suicide'. We demonstrated that this aggregation is independent of the chosen treatment, of intoxication status and of the presence of psychiatric problems. METHODS: 2314 Subjects, with alcohol, heroin or cocaine dependence were assigned to one of the five clusters...
2016: Annals of General Psychiatry
Brian J Cafferty, David M Fialho, Jaheda Khanam, Ramanarayanan Krishnamurthy, Nicholas V Hud
The RNA World hypothesis presupposes that abiotic reactions originally produced nucleotides, the monomers of RNA and universal constituents of metabolism. However, compatible prebiotic reactions for the synthesis of complementary (that is, base pairing) nucleotides and mechanisms for their mutual selection within a complex chemical environment have not been reported. Here we show that two plausible prebiotic heterocycles, melamine and barbituric acid, form glycosidic linkages with ribose and ribose-5-phosphate in water to produce nucleosides and nucleotides in good yields...
2016: Nature Communications
Stephen Vesper, Larry Wymer, David Cox, Gary Dewalt
Starting in the 1940s, gypsum drywall began replacing plaster and lathe in the U.S. home construction industry. Our goal was to evaluate whether some mold populations differ in water- damaged homes primarily constructed with gypsum drywall compared to plaster. The dust samples from the 2006 Department of Housing and Urban Development's (HUD) American Health Homes Survey (AHHS) were the subject of this analysis. The concentrations of the 36 Environmental Relative Moldiness Index (ERMI) molds were compared in homes of different ages...
August 15, 2016: Science of the Total Environment
Louise Pagh Winther, Jesper Fenger-Grøn
No abstract text is available yet for this article.
April 18, 2016: Ugeskrift for Laeger
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