keyword
https://read.qxmd.com/read/32381041/a-case-report-of-fatal-disseminated-fungal-sepsis-in-a-patient-with-ards-and-extracorporeal-membrane-oxygenation
#21
JOURNAL ARTICLE
Stefanie Prohaska, Philipp Henn, Svetlana Wenz, Leonie Frauenfeld, Peter Rosenberger, Helene A Haeberle
BACKGROUND: With the following report we want to present an unusual case of a patient suffering from acute respiratory distress syndrome with early discovery of bacterial pathogens in bronchoalveolar liquid samples that developed a fatal undiscovered disseminated fungal infection. CASE PRESENTATION: A 67-year-old man was admitted to our university hospital with dyspnea. Progressive respiratory failure developed leading to admission to the intensive care unit, intubation and prone positioning was necessary...
May 7, 2020: BMC Anesthesiology
https://read.qxmd.com/read/32305203/simultaneously-transplanted-pancreas-improves-salivation-and-reduces-oral-fungal-infections-incidence-in-type-1-diabetic-renal-transplant-recipients
#22
JOURNAL ARTICLE
Mikołaj Musiał, Rafał Wiench, Aureliusz Kolonko, Piotr Choręza, Damian Niedzielski, Agnieszka Machorowska-Pieniążek, Dariusz Skaba, Andrzej Więcek, Aleksander Owczarek, Iwona Niedzielska, Robert Król, Jacek Ziaja
BACKGROUND: Long-lasting diabetes mellitus may lead to numerous pathologies in the oral cavity. The aim of the study was to assess the condition of the oral cavity, caries intensity, salivary parameters, and incidence of oral fungal infections in patients with type 1 diabetes (T1D) and end-stage renal disease (ESRD) after kidney transplantation (KTx) or simultaneous kidney and pancreas transplantation (SPK). METHODS: Twenty-one patients after SPK, 18 T1D patients after KTx, and 14 kidney recipients without diabetes (control group) were included in the study...
April 15, 2020: Transplantation Proceedings
https://read.qxmd.com/read/31981389/incidence-and-outcomes-of-invasive-fungal-infection-among-solid-organ-transplant-recipients-a-population-based-cohort-study
#23
JOURNAL ARTICLE
Seyed M Hosseini-Moghaddam, Alexandra Ouédraogo, Kyla L Naylor, Sarah E Bota, Shahid Husain, Danielle M Nash, J Michael Paterson
BACKGROUND: Invasive fungal infection (IFI) in solid organ transplant (SOT) recipients is associated with significant morbidity and mortality. The long-term probability of post-transplant IFI is poorly understood. METHODS: We conducted a population-based cohort study using linked administrative healthcare databases from Ontario, Canada, to determine the incidence rate; 1-, 5-, and 10-year cumulative probabilities of IFI; and post-IFI all-cause mortality in SOT recipients from 2002 to 2016...
January 25, 2020: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/31915816/burden-and-timeline-of-infectious-diseases-in-the-first-year-after-solid-organ-transplantation-in-the-swiss-transplant-cohort-study
#24
JOURNAL ARTICLE
Christian van Delden, Susanne Stampf, Hans H Hirsch, Oriol Manuel, Pascal Meylan, Alexia Cusini, Cédric Hirzel, Nina Khanna, Maja Weisser, Christian Garzoni, Katja Boggian, Christoph Berger, David Nadal, Michael Koller, Ramon Saccilotto, Nicolas J Mueller
BACKGROUND: The burden and timeline of posttransplant infections are not comprehensively documented in the current era of immunosuppression and prophylaxis. METHODS: In this prospective study nested within the Swiss Transplant Cohort Study (STCS), all clinically relevant infections were identified by transplant-infectious diseases physicians in persons receiving solid organ transplant (SOT) between May 2008 and December 2014 with ≥12 months of follow-up. RESULTS: Among 3541 SOT recipients, 2761 (1612 kidney, 577 liver, 286 lung, 213 heart, and 73 kidney-pancreas) had ≥12 months of follow-up; 1520 patients (55%) suffered 3520 infections during the first year posttransplantation...
October 23, 2020: Clinical Infectious Diseases
https://read.qxmd.com/read/31779493/marine-bacterial-dnase-curtails-virulence-and-disrupts-biofilms-of-candida-albicans-and-non-albicans-candida-species
#25
JOURNAL ARTICLE
Sanaulla Farisa Banu, Subbiah Thamotharan, Shanmugaraj Gowrishankar, Shunmugiah Karutha Pandian, Paramasivam Nithyanand
Candida is one of the most prevalent fungal pathogens in clinical settings which form antibiotic-resistant biofilms on biomedical devices. Hence, there is a need for non-antimicrobial alternatives to combat these infections. The present study investigates the anti-biofilm effect of marine bacterial DNase by targeting the eDNA present in the biofilms of Candida spp. A strain of Vibrio alginolyticus (AMSII) which showed enhanced DNase activity was isolated from marine sediment. Treatment of young and mature Candida biofilms with purified marine bacterial DNase (MBD) caused a 60-80% reduction in biofilm biomass, similar to treatment with DNase I from Bovine pancreas...
November 29, 2019: Biofouling
https://read.qxmd.com/read/31691173/infectious-complications-in-severe-acute-pancreatitis-pathogens-drug-resistance-and-status-of-nosocomial-infection-in-a-university-affiliated-teaching-hospital
#26
JOURNAL ARTICLE
Hao Tian, Lang Chen, XingDa Wu, FuXing Li, Yi Ma, YiTong Cai, ShaoWei Song
BACKGROUND: Secondary infection is an important factor affecting mortality and quality of life in patients with severe acute pancreatitis. The characteristics of secondary infection, which are well known to clinicians, need to be re-examined in detail, and their understanding among clinicians needs to be updated accordingly. AIM: This study aims to investigate the characteristics and drug resistance of pathogens causing severe acute pancreatitis (SAP) secondary infection, to objectively present infection situation, and to provide reference for improved clinical management...
July 2020: Digestive Diseases and Sciences
https://read.qxmd.com/read/31670651/alemtuzumab-induction-for-retransplantation-after-primary-transplant-with-alemtuzumab-induction
#27
COMPARATIVE STUDY
Jillian L Descourouez, Margaret R Jorgenson, Sandesh Parajuli, Didier A Mandelbrot, Glen E Leverson, Jon S Odorico, Robert R Redfield
BACKGROUND: Lymphocyte-depleting induction with alemtuzumab (ALEM) or rabbit antithymocyte-globulin (rATG) is commonly used at retransplantation. It is unknown which agent is preferable, particularly when ALEM was used at primary transplant. OBJECTIVE: Evaluate outcomes after ALEM at retransplant following primary transplant with ALEM induction (ALEM-ALEM) as compared to retransplant with rATG (ALEM-rATG). MATERIALS AND METHODS: Single-center, observational cohort study of adult patients receiving kidney or pancreas transplant between January 1, 2001 and December 12, 2016...
February 2020: Clinical Nephrology
https://read.qxmd.com/read/31400149/the-incidence-of-fungal-infections-in-pancreas-transplant-recipients-in-the-absence-of-systemic-antifungal-prophylaxis
#28
JOURNAL ARTICLE
Suhail A Shaikh, Asha Zimmerman, Annelise Nolan, Matthew Cooper, Peter L Abrams
BACKGROUND: There is a lack of high-level evidence identifying meaningful outcomes and the place in therapy for systemic perioperative antifungal prophylaxis (ppx) in pancreas transplant recipients. As our program does not routinely utilize systemic perioperative antifungal ppx in pancreas transplant recipients, we assessed the incidence of post-transplant infectious complications. METHODS: This was a single-center, retrospective cohort study of consecutive adult pancreas transplant recipients between 01/2016 and 04/2018 to describe the incidence of fungal infections...
October 2019: Clinical Transplantation
https://read.qxmd.com/read/31169671/acute-lymphoblastic-leukemia-with-pancreas-involvement-in-an-adult-patient-mimicking-pancreatic-tumor-a-case-report
#29
JOURNAL ARTICLE
Yinghao Wang, Xuzhao Zhang, Linping Dong, Kezhong Tang, Heqing Fang, Zhe Tang, Bo Zhang
RATIONALE: Acute lymphoblastic leukemia (ALL) is a malignant disease originating from abnormal proliferation of B or T lymphocytes in bone marrow (BM). Invasion of the pancreas is extremely rare in adults. PATIENT CONCERNS: In this article, we report a case presenting that ALL invades the pancreas, as well as liver, kidney, and duodenum detected by magnetic resonance image. The patient was misdiagnosed as pancreatic tumor at initial since hemogram was unremarkable...
June 2019: Medicine (Baltimore)
https://read.qxmd.com/read/30722724/extrahepatic-nonreticuloendothelial-siderosis-is-not-specific-to-gestational-alloimmune-liver-disease
#30
JOURNAL ARTICLE
Hao Wu, William Ferguson, Eumenia Castro, Debra Kearney, Milton Finegold, Kalyani Patel
Autopsy reports of 78 stillbirths and early infant deaths (up to age 8 weeks) were reviewed to investigate the prevalence of extrahepatic nonreticuloendothelial siderosis (EHNRS) in the context of neonatal liver failure. Of these, 10 liveborns (12.8%), M:F 3:2, with mean gestational age 37.6 weeks (range: 35-39) and mean age at the time of demise 19.1 days (range: 7-42), showed significant liver injury: infection (n = 7, viral > fungal), congenital malformations (n = 2), and ischemia (n = 1)...
July 2019: Pediatric and Developmental Pathology
https://read.qxmd.com/read/30463516/pneumocystis-jiroveci-pneumonia-in-kidney-and-simultaneous-pancreas-kidney-transplant-recipients-in-the-present-era-of-routine-post-transplant-prophylaxis-risk-factors-and-outcomes
#31
JOURNAL ARTICLE
Neetika Garg, Margaret Jorgenson, Jillian Descourouez, Christopher M Saddler, Sandesh Parajuli, Brad C Astor, Arjang Djamali, Didier Mandelbrot
BACKGROUND: The goal of this study was to identify predictors for development of Pneumocystis jirovecii pneumonia (PJP) in kidney and simultaneous kidney and pancreas transplant recipients in the present era of universal primary prophylaxis. METHODS: We reviewed adult recipients of kidney transplant or simultaneous pancreas and kidney transplant at the University of Wisconsin between January 1, 1994 and December 31, 2016. Patients diagnosed with PJP during this time frame were included...
November 21, 2018: BMC Nephrology
https://read.qxmd.com/read/29359836/factors-and-outcomes-in-association-with-sepsis-differ-between-simultaneous-pancreas-kidney-and-single-kidney-transplant-recipients
#32
JOURNAL ARTICLE
Thomas Schachtner, Marina Zaks, Natalie M Otto, Andreas Kahl, Petra Reinke
BACKGROUND: As immunosuppressive therapy has improved in simultaneous pancreas/kidney transplant recipients (SPKTRs), infection has become the major limitation of disease-free survival. METHODS: We studied all SPKTRs and deceased-donor kidney transplant recipients (KTRs) between 2003 and 2015. Thirty-six of 134 SPKTRs (26.9%) were diagnosed with sepsis among which 13/36 SPKTRs (36.1%) developed severe sepsis/septic shock. A control group of 98 SPKTRs without sepsis and 61/538 KTRs (11...
April 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/28459079/pancreatic-fungal-ball-presenting-as-pseudomass
#33
JOURNAL ARTICLE
Naomi Chou, Rebecca Burbridge, Sarah Karram
Fungal infections of the pancreas have been shown to occur most commonly in the setting of necrotizing pancreatitis, pancreatic cysts, or pancreatic abscesses. Pancreatic fungal infections are rare without these predisposing factors, and may present similarly to pancreatic neoplasm. We report the case of a 48-year-old man who presented with epigastric abdominal pain, nausea, vomiting, and weight loss, with a potential mass in the head of the pancreas. The mass was resected via the Whipple procedure and was found to be a fungal collection with inflammatory cells and no malignancy...
2017: ACG Case Reports Journal
https://read.qxmd.com/read/28390190/systemic-scedosporium-prolificans-infection-in-an-11-month-old-border-collie-with-cobalamin-deficiency-secondary-to-selective-cobalamin-malabsorption-canine-imerslund-gr%C3%A3-sbeck-syndrome
#34
K Erles, A Mugford, D Barfield, T Leeb, P H Kook
An 11-month-old Border collie presented collapsed and continued to deteriorate rapidly despite supportive treatment. The dog had a history of failure to thrive and recurring respiratory infection. Laboratory abnormalities included neutrophilic leucocytosis, Heinz body anaemia, hyperammonaemia, hyperbilirubinaemia, proteinuria and hypocobalaminaemia. Post-mortem examination revealed multi-focal necrosis within the heart, kidneys, pancreas, liver, meninges and cerebral cortex. Fungal hyphae in lesions were identified as Scedosporium prolificans following culture...
April 2018: Journal of Small Animal Practice
https://read.qxmd.com/read/28193098/nanoparticle-formulation-increases-syzygium-cumini-antioxidant-activity-in-candida-albicans-infected-diabetic-rats
#35
JOURNAL ARTICLE
Paula E R Bitencourt, Lariane O Cargnelutti, Carolina S Stein, Raquel Lautenchleger, Luana M Ferreira, Manuela Sangoi, Laura Denardi, Raphaela M Borges, Aline Boligon, Rafael N Moresco, Letícia Cruz, Régis A Zanette, Sydney H Alves, Maria Beatriz Moretto
CONTEXT: Syzygium cumini (L.) Skeels (Myrtaceae) is a medicinal plant widely used in folk medicine for the treatment of diabetes mellitus (DM). However, studies on the use of this plant and of nanoparticle formulations against DM-related fungal infections are scarce. OBJECTIVE: To evaluate the effect of the treatments with aqueous seed extract of S. cumini (ASc) and ASc-loaded polymeric nanoparticles (NPASc) on biochemical parameters in Candida albicans-infected diabetic rats...
December 2017: Pharmaceutical Biology
https://read.qxmd.com/read/27965724/enterogenous-infection-of-candida-albicans-in-immunocompromised-rats-under-severe-acute-pancreatitis
#36
JOURNAL ARTICLE
Xiang-Wang Zhao, Lei Yan, Dan Xu, Yu-Hui Cui, Chun-Hui Yang, Yan-Jun Zhou, Jian-Guo Tang
BACKGROUND: Opportunistic infection of Candida albicans (C. albicans) has become a serious problem in immunocompromised patients. The study aimed to explore the mechanism of enterogenous infection of C. albicans in immunocompromised rats under severe acute pancreatitis (SAP). METHODS: Sprague Dawley (SD) rats (n=100) were randomly assigned into 5 groups as the following: blank group, cyclophosphamide+ceftriaxone+SAP group, cyclophosphamide+ceftriaxone group, cyclophosphamide+SAP group, and cyclophosphamide group...
2016: World Journal of Emergency Medicine
https://read.qxmd.com/read/27849440/use-of-cidofovir-for-cytomegalovirus-disease-refractory-to-ganciclovir-in-solid-organ-recipients
#37
JOURNAL ARTICLE
Hugo Bonatti, Costi D Sifri, Clara Larcher, Stefan Schneeberger, Camille Kotton, Christian Geltner
BACKGROUND: Solid organ transplantation (SOT) frequently is complicated by cytomegalovirus (CMV) infections. Cidofovir (CDV) is active against CMV, including many ganciclovir (GCV)-resistant mutants, but often is considered to be too nephrotoxic for use after organ transplantation. PATIENTS AND METHODS: Seven males and two females (median age 50.1 years), including two kidney/pancreas, four lung, one small bowel, and two hand recipients, received CDV for refractory CMV disease...
February 2017: Surgical Infections
https://read.qxmd.com/read/27742285/invasive-fungal-disease-in-renal-transplant-recipients-at-a-brazilian-center-local-epidemiology-matters
#38
JOURNAL ARTICLE
L F A Guimarães, M Halpern, A S de Lemos, E F de Gouvêa, R T Gonçalves, M A A da Rosa Santos, M Nucci, G Santoro-Lopes
INTRODUCTION: Invasive fungal disease (IFD) is an important complication after solid organ transplantation (SOT). A marked geographic variation in the epidemiology of IFD after kidney transplantation (KT) has been suggested by the results of previous studies. Nevertheless, data from Latin American centers are scarce. OBJECTIVE: This study sought to describe the epidemiology of IFD at a Brazilian KT center. METHODS: This study was a retrospective single-center cohort study that included patients who underwent KT between 1998 and 2009 and were followed up until July 2015...
September 2016: Transplantation Proceedings
https://read.qxmd.com/read/27332898/decision-making-in-necrotizing-pancreatitis
#39
JOURNAL ARTICLE
Thilo Hackert, Markus Wolfgang Büchler
The management of acute necrotizing pancreatitis (ANP) has undergone a change of paradigms during the last 2 decades with a decreasing impact of surgical interventions. Modern ANP management is done conservatively as long as possible and therapeutic approaches aim at volume resuscitation, pain management and early enteral nutrition. The diagnostic gold standard of contrast-enhanced CT scan helps to evaluate the extent of necrosis of the pancreas, which correlates with the risk of tissue infection. The crucial point for decision making is the proven existence of infected pancreatic necrosis...
2016: Digestive Diseases
https://read.qxmd.com/read/27067875/epico-3-0-antifungal-prophylaxis-in-solid-organ-transplant-recipients
#40
JOURNAL ARTICLE
Rafael Zaragoza, José María Aguado, Ricard Ferrer, Alejandro H Rodríguez, Emilio Maseda, Pedro Llinares, Santiago Grau, Patricia Muñoz, Jesús Fortún, Mercedes Bouzada, Juan Carlos Del Pozo, Rafael León
BACKGROUND: Although over the past decade the management of invasive fungal infection has improved, considerable controversy persists regarding antifungal prophylaxis in solid organ transplant recipients. AIMS: To identify the key clinical knowledge and make by consensus the high level recommendations required for antifungal prophylaxis in solid organ transplant recipients. METHODS: Spanish prospective questionnaire, which measures consensus through the Delphi technique, was conducted anonymously and by e-mail with 30 national multidisciplinary experts, specialists in invasive fungal infections from six national scientific societies, including intensivists, anesthetists, microbiologists, pharmacologists and specialists in infectious diseases that responded to 12 questions prepared by the coordination group, after an exhaustive review of the literature in the last few years...
2016: Revista Iberoamericana de Micología
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