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Magnesium in HD

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https://www.readbyqxmd.com/read/27895092/characterization-of-runella-slithyformis-hd-pnk-a-bifunctional-dna-rna-end-healing-enzyme-composed-of-an-n-terminal-2-3-phosphoesterase-hd-domain-and-a-c-terminal-5-oh-polynucleotide-kinase-domain
#1
Annum Munir, Stewart Shuman
: 5' and 3' end healing are key steps in nucleic acid break repair in which 5' -OH ends are phosphorylated by a polynucleotide kinase and 3' -PO4 or 2',3' -cyclic-PO4 ends are hydrolyzed by a phosphoesterase to generate the 5' -PO4 and 3' -OH termini required for sealing by classic polynucleotide ligases. End healing and sealing enzymes are present in diverse bacterial taxa, often organized as modular units within a single multifunctional polypeptide or as subunits of a repair complex...
November 28, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27593873/the-relationship-between-magnesium-and-endothelial-function-in-end-stage-renal-disease-patients-on-hemodialysis
#2
Shina Lee, Jung Hwa Ryu, Seung Jung Kim, Dong Ryeol Ryu, Duk Hee Kang, Kyu Bok Choi
PURPOSE: Chronic kidney disease (CKD) patients tend to have higher serum magnesium values than healthy population due to their positive balance of magnesium in kidney. Recent studies found that magnesium level is positively correlated with endothelial function. Therefore, this study was conducted to define the relationship between magnesium level and endothelial dysfunction in end stage renal disease (ESRD) patients on hemodialysis (HD). MATERIALS AND METHODS: A total of 27 patients were included in this cross-sectional study...
November 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27358470/bioenergetic-and-volume-regulatory-effects-of-mitokatp-channel-modulators-protect-against-hypoxia-reoxygenation-induced-mitochondrial-dysfunction
#3
John O Onukwufor, Don Stevens, Collins Kamunde
The mitochondrial ATP-sensitive K(+) (mitoKATP) channel plays a significant role in mitochondrial physiology and protects against ischemic reperfusion injury in mammals. Although fish frequently face oxygen fluctuations in their environment, the role of the mitoKATP channel in regulating the responses to oxygen stress is rarely investigated in this class of animals. To elucidate whether and how the mitoKATP channel protects against hypoxia-reoxygenation (H-R)-induced mitochondrial dysfunction in fish, we first determined the mitochondrial bioenergetic effects of two key modulators of the channel, diazoxide and 5-hydroxydecanoate (5-HD), using a wide range of doses...
September 1, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27274837/sevelamer-carbonate-reduces-the-risk-of-hypomagnesemia-in-hemodialysis-requiring-end-stage-renal-disease-patients
#4
Guillermo Rosa-Diez, Armando Luis Negri, Maria Soledad Crucelegui, Romina Philippi, Hernán Perez-Teysseyre, Carmen Sarabia-Reyes, Henry Loor-Navarrete, Ricardo Heguilen
BACKGROUND: Sevelamer has been associated with less progression of vascular calcifications. This effect could be due to a reduction in serum phosphate levels but also to other additive effects. Magnesium has been also shown to prevent vascular calcification but the effect of sevelamer on serum magnesium levels has not been thoroughly evaluated. Our aim was to analyze whether the use of sevelamer reduces the risk of hypomagnesemia in hemodialysis (HD)-requiring end-stage renal disease patients...
June 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27064679/high-flux-hemodialysis-and-high-volume-hemodiafiltration-improve-serum-calcification-propensity
#5
Marijke Dekker, Andreas Pasch, Frank van der Sande, Constantijn Konings, Matthias Bachtler, Mauro Dionisi, Matthias Meier, Jeroen Kooman, Bernard Canaud
BACKGROUND: Calciprotein particles (CPPs) may play an important role in the calcification process. The calcification propensity of serum (T50) is highly predictive of all-cause mortality in chronic kidney disease patients. Whether T50 is therapeutically improvable, by high-flux hemodialysis (HD) or hemodiafiltration (HDF), has not been studied yet. METHODS: We designed a cross-sectional single center study, and included stable prevalent in-center dialysis patients on HD or HDF...
2016: PloS One
https://www.readbyqxmd.com/read/27023929/calcium-acetate-magnesium-carbonate-and-cardiovascular-risk-factors-in-chronic-hemodialysis-patients
#6
Patrícia João Matias, Cristina Jorge, Ana Azevedo, Ivo Laranjinha, David Navarro, Marco Mendes, Tiago Amaral, Carina Ferreira, Inês Aires, Célia Gil, Stefano Stuard, Aníbal Ferreira
BACKGROUND/AIM: Calcium acetate/magnesium carbonate (CaMg) is a recent phosphate binder that has been shown to have protective cardiovascular (CV) effects in animal models. The aim of this study was to evaluate the relationship between CaMg therapy and CV risk markers like pulse pressure (PP), left ventricular mass index (LVMI) and valvular calcifications compared to sevelamer or no phosphate binder (NPB) therapy in chronic hemodialysis (HD) patients. METHODS: We performed a 48-month prospective study in 138 HD patients under hemodiafiltration with a dialysate Mg concentration of 0...
2016: Nephron
https://www.readbyqxmd.com/read/26997375/serum-magnesium-level-and-vascular-stiffness-in-children-with-chronic-kidney-disease-on-regular-hemodialysis
#7
Manal Mohamed Zaher, Manal Abdel-Salam, Ragaa Abdel-Salam, Randa Sabour, Amal Abd El-Aleem Morsy, Dina Gamal
Chronic kidney disease (CKD) patients have a high prevalence of vascular calcifications, and cardiovascular disease is the leading cause of death in this population. Magnesium (Mg) depletion may be the missing link between multiple cardiovascular risk factors and the development of atherosclerosis. In this study, we aimed to assess the relationship between serum Mg levels and vascular stiffness in children with CKD on regular hemodialysis (HD). The study included 25 children with CKD on regular HD in our center; the study included also 25 healthy children age-and sex-matched as a control group...
March 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/26905320/is-there-a-relationship-between-hypomagnesemia-and-proton-pump-inhibitors-in-patients-on-chronic-hemodialysis
#8
I Mikolasevic, S Milic, D Stimac, L Zaputovic, V Lukenda Zanko, T Gulin, I Jakopcic, D Klaric, M Gulin, L Orlic
AIM: We investigated the association among long-term proton-pump inhibitors (PPIs) use with serum magnesium (Mg) levels in chronic hemodialysis (HD) patients, as well as possible association among PPI use and increased risk of cardiovascular (CVD) morbidity in HD patients. METHODS: Of 418 HD patients that were screened for inclusion, 136 were excluded due to incomplete medical data, duration of renal replacement therapy (RRT) for less than 12months, use of Mg-based-phosphate binders or other Mg-based medications or either to presence of chronic increased GI losses...
May 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/26814105/-risk-factors-for-coronary-artery-calcification-in-patients-with-end-stage-renal-disease
#9
Liwen Cui, Jinsheng Xu, Yaling Bai, Junxia Zhang
OBJECTIVE: To explore risk factors for coronary artery calcification (CAC) inpatients with end-stage renal disease (ESRD). METHODS: A total of 53 ESRD patients undergoing regular hemodialysis (3 times a week) from August 2014 to March 2015 in the Fourth Hospital of Hebei Medical University were enrolled in the study. The patients were divided into the negative control group (13 cases) and three positive groups (11 mild calcification cases, 12 moderate calcification cases and 17 severe calcification cases) based on coronary artery calcification score (CACs)...
October 13, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26702005/chronic-kidney-disease-mineral-bone-disorder-in-the-elderly-peritoneal-dialysis-patient
#10
REVIEW
James Goya Heaf
PURPOSE: The purpose of this paper was to review the literature concerning the treatment of chronic kidney disease-mineral bone disorder (CKD-MBD) in the elderly peritoneal dialysis (PD) patient. RESULTS: Chronic kidney disease-mineral bone disorder is a major problem in the elderly PD patient, with its associated increased fracture risk, vascular calcification, and accelerated mortality fracture risk. Peritoneal dialysis, however, bears a lower risk than hemodialysis (HD)...
November 2015: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/26600017/serum-magnesium-and-sudden-death-in-european-hemodialysis-patients
#11
RANDOMIZED CONTROLLED TRIAL
Camiel L M de Roij van Zuijdewijn, Muriel P C Grooteman, Michiel L Bots, Peter J Blankestijn, Sonja Steppan, Janine Büchel, Rolf H H Groenwold, Vincent Brandenburg, Marinus A van den Dorpel, Piet M Ter Wee, Menso J Nubé, Marc G Vervloet
Despite suggestions that higher serum magnesium (Mg) levels are associated with improved outcome, the association with mortality in European hemodialysis (HD) patients has only scarcely been investigated. Furthermore, data on the association between serum Mg and sudden death in this patient group is limited. Therefore, we evaluated Mg in a post-hoc analysis using pooled data from the CONvective TRAnsport STudy (CONTRAST, NCT00205556), a randomized controlled trial (RCT) evaluating the survival risk in dialysis patients on hemodiafiltration (HDF) compared to HD with a mean follow-up of 3...
2015: PloS One
https://www.readbyqxmd.com/read/26571490/got-milk-breastfeeding-and-milk-analysis-of-a-mother-on-chronic-hemodialysis
#12
Michael S Balzer, Mechthild M Gross, Ralf Lichtinghagen, Hermann Haller, Roland Schmitt
PURPOSE: Women on dialysis rarely become pregnant. However, the overall rate of successful pregnancies is increasing in this patient population and breastfeeding becomes an option for mothers on dialysis. In this study we performed a systematic breast milk composition analysis of a mother on chronic hemodialysis (HD). METHODS: Specimens of breast milk and blood were collected in regular intervals before and after HD from a 39-year old woman starting on day 10 postpartum...
2015: PloS One
https://www.readbyqxmd.com/read/26479205/application-of-phenol-amine-copolymerized-film-modified-magnesium-alloys-anticorrosion-and-surface-biofunctionalization
#13
Si Chen, Jiang Zhang, Yingqi Chen, Sheng Zhao, Meiyun Chen, Xin Li, Manfred F Maitz, Jin Wang, Nan Huang
Magnesium metal as degradable metallic material is one of the most researched areas, but its rapid degradation rate restricts its development. The current anticorrosion surface modification methods require expensive equipment and complicated operation processes and cannot continue to introduce biofunction on modified surface. In this study, the GAHD conversion coatings were fabricated on the surface of magnesium alloys (MZM) by incubating in the mixture solution of gallic acid (GA) and hexamethylenediamine (HD) to decrease the corrosion rate and provide primary amines (-NH2), carboxyl (-COOH), and quinone groups, which is supposed to introduce biomolecules on MZM...
November 11, 2015: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26413285/optimizing-haemodialysate-composition
#14
REVIEW
Francesco Locatelli, Vincenzo La Milia, Leano Violo, Lucia Del Vecchio, Salvatore Di Filippo
Survival and quality of life of dialysis patients are strictly dependent on the quality of the haemodialysis (HD) treatment. In this respect, dialysate composition, including water purity, plays a crucial role. A major aim of HD is to normalize predialysis plasma electrolyte and mineral concentrations, while minimizing wide swings in the patient's intradialytic plasma concentrations. Adequate sodium (Na) and water removal is critical for preventing intra- and interdialytic hypotension and pulmonary edema. Avoiding both hyper- and hypokalaemia prevents life-threatening cardiac arrhythmias...
October 2015: Clinical Kidney Journal
https://www.readbyqxmd.com/read/26351590/novel-therapies-for-myocardial-irritability-following-extreme-hydroxychloroquine-toxicity
#15
Paul B McBeth, Perseus I Missirlis, Harry Brar, Vinay Dhingra
Introduction. Hydroxychloroquine (HCQ) overdose is rare and potentially deadly when consumed in large doses. Management of severe HCQ toxicity is limited and infrequently reported. This report presents the case of a massive ingestion of HCQ. Case Report. A 23-year-old female presents following an intentional ingestion of approximately 40 g of HCQ. Within six hours after ingestion, she developed severe hemodynamic instability resulting from myocardial irritability with frequent ventricular ectopic activity leading to runs of polymorphic ventricular tachycardia (PMVT) and ventricular fibrillation (VF) requiring multiple defibrillations...
2015: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/26268579/the-relationship-between-proton-pump-inhibitor-use-and-serum-magnesium-concentration-among-hemodialysis-patients-a-cross-sectional-study
#16
Paraish S Misra, Ahsan Alam, Mark L Lipman, Sharon J Nessim
BACKGROUND: Observational data suggest that serum magnesium (Mg) concentration is inversely related to vascular calcification and hyperparathyroidism among patients with end-stage renal disease (ESRD). In recent years, there have been several case reports of hypomagnesemia due to use of proton-pump inhibitors (PPI), with the hypomagnesemia attributed to inappropriate gastrointestinal (GI) Mg loss. We hypothesized that the tendency to GI Mg loss is more common than is currently reported...
2015: BMC Nephrology
https://www.readbyqxmd.com/read/26190226/serum-magnesium-and-mortality-in-hemodialysis-patients-in-the-united-states-a-cohort-study
#17
Eduardo Lacson, Weiling Wang, Lin Ma, Jutta Passlick-Deetjen
BACKGROUND: Low serum magnesium levels in patients with kidney disease have been linked to increased mortality. This study investigated whether similar associations existed in maintenance hemodialysis (HD) patients. STUDY DESIGN: Cohort study. SETTING & PARTICIPANTS: All Fresenius Medical Care North America in-center HD patients with available serum magnesium measurements were studied. The initial exploratory study in 21,534 HD patients evaluated associations among serum magnesium level, dialysate magnesium concentration, and mortality from April 2007 through June 2008...
December 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26184377/hypomagnesemia-and-mortality-in-incident-hemodialysis%C3%A2-patients
#18
Lin Li, Elani Streja, Connie M Rhee, Rajnish Mehrotra, Melissa Soohoo, Steven M Brunelli, Csaba P Kovesdy, Kamyar Kalantar-Zadeh
BACKGROUND: In the general population, low serum magnesium levels are associated with poor outcomes and death. While limited data suggest that low baseline magnesium levels may be associated with higher mortality in hemodialysis (HD) patients, the impact of changes in magnesium levels over time is unknown. STUDY DESIGN: We examined the association of time-varying serum magnesium levels with all-cause mortality using multivariable time-varying survival models adjusted for clinical characteristics and other time-varying laboratory measures...
December 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26007218/prevalence-and-clinical-impact-of-magnesium-disorders-in-end-stage-renal-disease-a-protocol-for-a-systematic-review
#19
REVIEW
John Floridis, Asanga Abeyaratne, Sandawana William Majoni
BACKGROUND: Magnesium plays a key role in maintaining internal homeostasis through actions in the musculoskeletal, nervous, endocrine and cellular messenger systems. Renal excretion is the major route of magnesium elimination from the body. A positive magnesium balance would be expected in renal failure. However, a compensatory decrease in tubular reabsorption is expected to operate to maintain adequate urinary magnesium excretion even when glomerular filtration rate is very low. Patients with end-stage renal disease and those on dialysis have impaired regulatory mechanisms, predisposing them to disturbances in magnesium levels...
2015: Systematic Reviews
https://www.readbyqxmd.com/read/25828570/dialysate-and-serum-potassium-in-hemodialysis
#20
REVIEW
Adriana M Hung, Raymond M Hakim
Most patients with end-stage renal disease depend on intermittent hemodialysis to maintain levels of serum potassium and other electrolytes within a normal range. However, one of the challenges has been the safety of using a low-potassium dialysate to achieve that goal, given the concern about the effects that rapid and/or large changes in serum potassium concentrations may have on cardiac electrophysiology and arrhythmia. Additionally, in this patient population, there is a high prevalence of structural cardiac changes and ischemic heart disease, making them even more susceptible to acute arrhythmogenic triggers...
July 2015: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
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