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Magnesium in HD

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https://www.readbyqxmd.com/read/28755998/loperamide-induced-torsades-de-pointes-a-case-series
#1
Kenneth D Katz, Robert D Cannon, Matthew D Cook, Alexandra Amaducci, Ryan Day, Joshua Enyart, Glenn Burket, Lauren Porter, Timothy Roach, Jennifer Janssen, Karl E Williams
Loperamide is an over-the-counter, inexpensive, antidiarrheal opioid that can produce life-threatening toxicity at high concentrations. CASE REPORT 1: A 28-year-old man with a history of depression and substance abuse disorder (SUD) presented to the emergency department (ED) with shortness of breath and lightheadedness. He ingested large amounts of loperamide daily. The patient's initial electrocardiogram (ECG) demonstrated sinus rhythm, right axis deviation, undetectable PR interval, QRS 168 ms, and QTc 693 ms...
July 26, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28708214/hypomagnesemia-and-cause-specific-mortality-in-hemodialysis-patients-5-year-follow-up-analysis
#2
Gjulsen N Selim, Goce Spasovski, Liljana Tozija, Ljubica Georgievska-Ismail, Beti Zafirova-Ivanovska, Jelka Masin-Spasovska, Irena Rambabova-Busletic, Zvezdana Petronijevic, Pavlina Dzekova-Vidimliski, Vesna Ristovska, Vladimir Pusevski, Olivera Stojceva-Taneva
INTRODUCTION: The aim of this prospective study was to evaluate the association between serum magnesium (Mg) and mortality, in particular the cause-specific mortality of Mg and other risk factors in hemodialysis (HD) patients. METHODS: We studied a cohort of 185 HD patients receiving thrice-weekly HD treatment, on a dialysate Mg concentration of 0.5 mmol/L. We stratified 3 patient groups according to the level of Mg: lower (<1.1 mmol/L), intermediate-reference (1...
July 1, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28325719/near-death-by-milk-of-magnesia
#3
Ahmed Alaini, Carlos A Roldan, Karen Servilla, Elizabeth Sage Colombo
We report a case of hypermagnesemia associated with the use of milk of magnesia in a male patient with end-stage renal disease. After experiencing nausea and vomiting, he developed severe bradycardia and then asystole. Resuscitation efforts were successful; however, he developed atrial fibrillation with severe widening of the QRS and diffuse ST elevation, hypothermia, hypotension and apnoea requiring intubation. Initial diagnoses included ST-elevation myocardial infarction, cardiogenic and/or septic shock and hyperkalaemia...
March 21, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28265965/hypophosphatemia-nutritional-status-body-composition-and-mortality-in-hemodialysis-patients
#4
Cristina Garagarza, Ana Valente, Cristina Caetano, Telma Oliveira, Pedro Ponce, Ana Paula Silva
PURPOSE: The aim of the present study was to investigate the relationship between serum phosphate levels, clinical parameters, body composition, and mortality. METHODS: Multicenter longitudinal observational study of a cohort of 3552 patients in hemodialysis (HD) from 34 Nephrocare dialysis units in Portugal with 24 months of follow-up. Patients were divided into three groups depending on their serum phosphorus (<3.5; 3.5-5.5; >5.5 mg/dL). Statistical tests were performed with SPSS, version 20...
July 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28128490/the-role-of-holes-in-borophenes-an-ab%C3%A2-initio-study-of-their-structure-and-stability-with-and-without-metal-templates
#5
Naiwrit Karmodak, Eluvathingal D Jemmis
An electron-counting strategy starting from magnesium boride was used to show the inevitability of hexagonal holes in 2D borophene. The number (hole density, HD) and distribution of the hexagonal holes determine the binding energy per boron atom in monolayer borophenes. The relationship between binding energy and HD changes dramatically when the borophene is placed on a Ag(111) surface. The distribution of holes in borophenes on Ag(111) surfaces depends on the temperature. DFT calculations show that aside from the previously reported S1 and S2 borophene phases, other polymorphs may also be competitive...
January 27, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/27965186/impact-of-sevelamer-hydrochloride-on-serum-magnesium-concentrations-in-hemodialysis-patients
#6
Ryota Ikee, Takayuki Toyoyama, Toko Endo, Masataka Tsunoda, Nobuo Hashimoto
Serum Mg levels are elevated in patients with renal insufficiency: harmful effects of hypomagnesemia have been reported in patients receiving hemodialysis (HD). In this cross-sectional study, which included 86 HD patients (male : female = 56:30, age 68 ± 12 years), we examined the clinical factors associated with serum Mg levels, with a focus on sevelamer, a phosphate binder widely used to control the hyperphosphatemia of HD patients. The mean serum Mg concentration among our patients was 2.48 ± 0.37 mg/dL (1...
April 1, 2016: Magnesium Research: Official Organ of the International Society for the Development of Research on Magnesium
https://www.readbyqxmd.com/read/27943168/hemodialysis-induced-repolarization-abnormalities-on-ecg-are-influenced-by-serum-calcium-levels-and-ultrafiltration-volumes
#7
Hande Ozportakal, Abdullah Ozkok, Ozlem Alkan, Ahmet Sait Bulut, Memduha Boyraz, Mehmet Inanir, Goksel Acar, Ali Riza Odabas
PURPOSE: Hemodialysis (HD) patients are known to have high cardiovascular mortality rate. Sudden cardiac death (SCD) due to arrhythmias causes most of the cardiac deaths. HD per se may lead to ECG abnormalities and ventricular arrhythmias. Monitoring ECG parameters such as corrected QT interval, QT dispersion (QTd), Tpe interval may be useful to stratify the patients with high risk of arrhythmia and SCD. Herein we aimed to investigate the effects of changes in serum electrolyte levels and pH on ECG parameters before and after the HD...
December 10, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27895092/characterization-of-runella-slithyformis-hd-pnk-a-bifunctional-dna-rna-end-healing-enzyme-composed-of-an-n-terminal-2-3-phosphoesterase-hd-domain-and-a-c-terminal-5-oh-polynucleotide-kinase-domain
#8
Annum Munir, Stewart Shuman
5' and 3' end healing are key steps in nucleic acid break repair in which 5' -OH ends are phosphorylated by a polynucleotide kinase and 3' -PO4 or 2',3' -cyclic-PO4 ends are hydrolyzed by a phosphoesterase to generate the 5' -PO4 and 3' -OH termini required for sealing by classic polynucleotide ligases. End healing and sealing enzymes are present in diverse bacterial taxa, often organized as modular units within a single multifunctional polypeptide or as subunits of a repair complex. Here we identify and characterize Runella slithyformis HD-Pnk as a novel bifunctional end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase P-loop domain...
November 28, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/27593873/the-relationship-between-magnesium-and-endothelial-function-in-end-stage-renal-disease-patients-on-hemodialysis
#9
Shina Lee, Jung Hwa Ryu, Seung Jung Kim, Dong Ryeol Ryu, Duk Hee Kang, Kyu Bok Choi
PURPOSE: Chronic kidney disease (CKD) patients tend to have higher serum magnesium values than healthy population due to their positive balance of magnesium in kidney. Recent studies found that magnesium level is positively correlated with endothelial function. Therefore, this study was conducted to define the relationship between magnesium level and endothelial dysfunction in end stage renal disease (ESRD) patients on hemodialysis (HD). MATERIALS AND METHODS: A total of 27 patients were included in this cross-sectional study...
November 2016: Yonsei Medical Journal
https://www.readbyqxmd.com/read/27358470/bioenergetic-and-volume-regulatory-effects-of-mitokatp-channel-modulators-protect-against-hypoxia-reoxygenation-induced-mitochondrial-dysfunction
#10
John O Onukwufor, Don Stevens, Collins Kamunde
The mitochondrial ATP-sensitive K(+) (mitoKATP) channel plays a significant role in mitochondrial physiology and protects against ischemic reperfusion injury in mammals. Although fish frequently face oxygen fluctuations in their environment, the role of the mitoKATP channel in regulating the responses to oxygen stress is rarely investigated in this class of animals. To elucidate whether and how the mitoKATP channel protects against hypoxia-reoxygenation (H-R)-induced mitochondrial dysfunction in fish, we first determined the mitochondrial bioenergetic effects of two key modulators of the channel, diazoxide and 5-hydroxydecanoate (5-HD), using a wide range of doses...
September 1, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27274837/sevelamer-carbonate-reduces-the-risk-of-hypomagnesemia-in-hemodialysis-requiring-end-stage-renal-disease-patients
#11
Guillermo Rosa-Diez, Armando Luis Negri, Maria Soledad Crucelegui, Romina Philippi, Hernán Perez-Teysseyre, Carmen Sarabia-Reyes, Henry Loor-Navarrete, Ricardo Heguilen
BACKGROUND: Sevelamer has been associated with less progression of vascular calcifications. This effect could be due to a reduction in serum phosphate levels but also to other additive effects. Magnesium has been also shown to prevent vascular calcification but the effect of sevelamer on serum magnesium levels has not been thoroughly evaluated. Our aim was to analyze whether the use of sevelamer reduces the risk of hypomagnesemia in hemodialysis (HD)-requiring end-stage renal disease patients...
June 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27064679/high-flux-hemodialysis-and-high-volume-hemodiafiltration-improve-serum-calcification-propensity
#12
Marijke Dekker, Andreas Pasch, Frank van der Sande, Constantijn Konings, Matthias Bachtler, Mauro Dionisi, Matthias Meier, Jeroen Kooman, Bernard Canaud
BACKGROUND: Calciprotein particles (CPPs) may play an important role in the calcification process. The calcification propensity of serum (T50) is highly predictive of all-cause mortality in chronic kidney disease patients. Whether T50 is therapeutically improvable, by high-flux hemodialysis (HD) or hemodiafiltration (HDF), has not been studied yet. METHODS: We designed a cross-sectional single center study, and included stable prevalent in-center dialysis patients on HD or HDF...
2016: PloS One
https://www.readbyqxmd.com/read/27023929/calcium-acetate-magnesium-carbonate-and-cardiovascular-risk-factors-in-chronic-hemodialysis-patients
#13
Patrícia João Matias, Cristina Jorge, Ana Azevedo, Ivo Laranjinha, David Navarro, Marco Mendes, Tiago Amaral, Carina Ferreira, Inês Aires, Célia Gil, Stefano Stuard, Aníbal Ferreira
BACKGROUND/AIM: Calcium acetate/magnesium carbonate (CaMg) is a recent phosphate binder that has been shown to have protective cardiovascular (CV) effects in animal models. The aim of this study was to evaluate the relationship between CaMg therapy and CV risk markers like pulse pressure (PP), left ventricular mass index (LVMI) and valvular calcifications compared to sevelamer or no phosphate binder (NPB) therapy in chronic hemodialysis (HD) patients. METHODS: We performed a 48-month prospective study in 138 HD patients under hemodiafiltration with a dialysate Mg concentration of 0...
2016: Nephron
https://www.readbyqxmd.com/read/26997375/serum-magnesium-level-and-vascular-stiffness-in-children-with-chronic-kidney-disease-on-regular-hemodialysis
#14
Manal Mohamed Zaher, Manal Abdel-Salam, Ragaa Abdel-Salam, Randa Sabour, Amal Abd El-Aleem Morsy, Dina Gamal
Chronic kidney disease (CKD) patients have a high prevalence of vascular calcifications, and cardiovascular disease is the leading cause of death in this population. Magnesium (Mg) depletion may be the missing link between multiple cardiovascular risk factors and the development of atherosclerosis. In this study, we aimed to assess the relationship between serum Mg levels and vascular stiffness in children with CKD on regular hemodialysis (HD). The study included 25 children with CKD on regular HD in our center; the study included also 25 healthy children age-and sex-matched as a control group...
March 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/26905320/is-there-a-relationship-between-hypomagnesemia-and-proton-pump-inhibitors-in-patients-on-chronic-hemodialysis
#15
I Mikolasevic, S Milic, D Stimac, L Zaputovic, V Lukenda Zanko, T Gulin, I Jakopcic, D Klaric, M Gulin, L Orlic
AIM: We investigated the association among long-term proton-pump inhibitors (PPIs) use with serum magnesium (Mg) levels in chronic hemodialysis (HD) patients, as well as possible association among PPI use and increased risk of cardiovascular (CVD) morbidity in HD patients. METHODS: Of 418 HD patients that were screened for inclusion, 136 were excluded due to incomplete medical data, duration of renal replacement therapy (RRT) for less than 12months, use of Mg-based-phosphate binders or other Mg-based medications or either to presence of chronic increased GI losses...
May 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/26814105/-risk-factors-for-coronary-artery-calcification-in-patients-with-end-stage-renal-disease
#16
Liwen Cui, Jinsheng Xu, Yaling Bai, Junxia Zhang
OBJECTIVE: To explore risk factors for coronary artery calcification (CAC) inpatients with end-stage renal disease (ESRD). METHODS: A total of 53 ESRD patients undergoing regular hemodialysis (3 times a week) from August 2014 to March 2015 in the Fourth Hospital of Hebei Medical University were enrolled in the study. The patients were divided into the negative control group (13 cases) and three positive groups (11 mild calcification cases, 12 moderate calcification cases and 17 severe calcification cases) based on coronary artery calcification score (CACs)...
October 13, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26702005/chronic-kidney-disease-mineral-bone-disorder-in-the-elderly-peritoneal-dialysis-patient
#17
REVIEW
James Goya Heaf
PURPOSE: The purpose of this paper was to review the literature concerning the treatment of chronic kidney disease-mineral bone disorder (CKD-MBD) in the elderly peritoneal dialysis (PD) patient. RESULTS: Chronic kidney disease-mineral bone disorder is a major problem in the elderly PD patient, with its associated increased fracture risk, vascular calcification, and accelerated mortality fracture risk. Peritoneal dialysis, however, bears a lower risk than hemodialysis (HD)...
November 2015: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/26600017/serum-magnesium-and-sudden-death-in-european-hemodialysis-patients
#18
RANDOMIZED CONTROLLED TRIAL
Camiel L M de Roij van Zuijdewijn, Muriel P C Grooteman, Michiel L Bots, Peter J Blankestijn, Sonja Steppan, Janine Büchel, Rolf H H Groenwold, Vincent Brandenburg, Marinus A van den Dorpel, Piet M Ter Wee, Menso J Nubé, Marc G Vervloet
Despite suggestions that higher serum magnesium (Mg) levels are associated with improved outcome, the association with mortality in European hemodialysis (HD) patients has only scarcely been investigated. Furthermore, data on the association between serum Mg and sudden death in this patient group is limited. Therefore, we evaluated Mg in a post-hoc analysis using pooled data from the CONvective TRAnsport STudy (CONTRAST, NCT00205556), a randomized controlled trial (RCT) evaluating the survival risk in dialysis patients on hemodiafiltration (HDF) compared to HD with a mean follow-up of 3...
2015: PloS One
https://www.readbyqxmd.com/read/26571490/got-milk-breastfeeding-and-milk-analysis-of-a-mother-on-chronic-hemodialysis
#19
Michael S Balzer, Mechthild M Gross, Ralf Lichtinghagen, Hermann Haller, Roland Schmitt
PURPOSE: Women on dialysis rarely become pregnant. However, the overall rate of successful pregnancies is increasing in this patient population and breastfeeding becomes an option for mothers on dialysis. In this study we performed a systematic breast milk composition analysis of a mother on chronic hemodialysis (HD). METHODS: Specimens of breast milk and blood were collected in regular intervals before and after HD from a 39-year old woman starting on day 10 postpartum...
2015: PloS One
https://www.readbyqxmd.com/read/26479205/application-of-phenol-amine-copolymerized-film-modified-magnesium-alloys-anticorrosion-and-surface-biofunctionalization
#20
Si Chen, Jiang Zhang, Yingqi Chen, Sheng Zhao, Meiyun Chen, Xin Li, Manfred F Maitz, Jin Wang, Nan Huang
Magnesium metal as degradable metallic material is one of the most researched areas, but its rapid degradation rate restricts its development. The current anticorrosion surface modification methods require expensive equipment and complicated operation processes and cannot continue to introduce biofunction on modified surface. In this study, the GAHD conversion coatings were fabricated on the surface of magnesium alloys (MZM) by incubating in the mixture solution of gallic acid (GA) and hexamethylenediamine (HD) to decrease the corrosion rate and provide primary amines (-NH2), carboxyl (-COOH), and quinone groups, which is supposed to introduce biomolecules on MZM...
November 11, 2015: ACS Applied Materials & Interfaces
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