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https://www.readbyqxmd.com/read/29869117/validating-the-use-of-bioimpedance-spectroscopy-for-assessment-of-fluid-status-in-children
#1
Indranil Dasgupta, David Keane, Elizabeth Lindley, Ihab Shaheen, Kay Tyerman, Franz Schaefer, Elke Wühl, Manfred J Müller, Anja Bosy-Westphal, Hans Fors, Jovanna Dahlgren, Paul Chamney, Peter Wabel, Ulrich Moissl
BACKGROUND: Bioimpedance spectroscopy (BIS) with a whole-body model to distinguish excess fluid from major body tissue hydration can provide objective assessment of fluid status. BIS is integrated into the Body Composition Monitor (BCM) and is validated in adults, but not children. This study aimed to (1) assess agreement between BCM-measured total body water (TBW) and a gold standard technique in healthy children, (2) compare TBW_BCM with TBW from Urea Kinetic Modelling (UKM) in haemodialysis children and (3) investigate systematic deviation from zero in measured excess fluid in healthy children across paediatric age range...
June 4, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29845936/home-haemodialysis-in-the-netherlands-state-of-the-art
#2
A A Bonenkamp, M K van Gelder, A C Abrahams, F T J Boereboom, T Cornelis, A J Luik, A Özyilmaz, F M van der Sande, A van Eck van der Sluijs, K G F Gerritsen, B C van Jaarsveld
Home haemodialysis (HHD) has gained popularity in recent years, due to improved clinical outcomes associated with frequent or prolonged haemodialysis sessions, best achievable at home. However, several barriers to HHD are perceived by the physician and patient, among which lack of experience and education, logistic difficulties and reimbursement issues seem to be the most important ones. HHD, in particular when performed with intensified frequency or duration, is associated with improved quality of life, blood pressure control and survival...
May 2018: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/29785733/left-ventricular-strain-analysis-using-cardiac-mri-in-patients-undergoing-in-centre-nocturnal-hemodialysis
#3
Jann Patrick Ong, Ron Wald, Marc B Goldstein, Jonathon Leipsic, Mercedeh Kiaii, Djeven P Deva, Anish Kirpalani, Laura Jimenez-Juan, Olugbenga Bello, Paymon M Azizi, Rachel M Wald, Graham A Wright, Ziv Harel, Kim A Connelly, Andrew T Yan
AIM: Intensified haemodialysis is associated with regression of left ventricular (LV) mass. Compared to LV ejection fraction, LV strain allows more direct assessment of LV function. We sought to assess the impact of in-centre nocturnal haemodialysis (INHD) on global LV strain (radial, circumferential, and longitudinal) and torsion by cardiac MRI (CMR). METHODS: In this prospective, 2-centre cohort study, 37 participants on conventional haemodialysis (CHD, 3-4 hours/session for 3 sessions/week) converted to INHD (7-8 hours/session for 3 sessions/week) and 30 participants continued CHD...
May 21, 2018: Nephrology
https://www.readbyqxmd.com/read/29685550/assessment-of-right-ventricular-dysfunction-in-end-stage-renal-disease-patients-on-maintenance-haemodialysis-by-cardiac-magnetic-resonance-imaging
#4
Wanlin Peng, Zhenlin Li, Huayan Xu, Chunchao Xia, Yingkun Guo, Jinge Zhang, Keling Liu, Yuming Li, Jin Pu, Huapeng Zhang, Tianlei Cui
PURPOSE: To assess right ventricular (RV) dysfunction in end-stage renal disease (ESRD) patients on maintenance haemodialysis (HD) by cardiac magnetic resonance (CMR) imaging and determined the risk factors associated with RV dysfunction. MATERIALS AND METHODS: Fifty ESRD patients on maintenance HD and 16 age- and gender-matched healthy individuals were prospectively enrolled and underwent CMR imaging. Left ventricular (LV) and RV function parameters, including end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and ejection fraction (EF), were measured and compared...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29681225/the-united-kingdom-and-ireland-experience-of-the-haemodialysis-reliable-outflow-graft-for-vascular-access
#5
James P Hunter, Simon R Knight, N Inston, D Ridway, A Tavakoli, S Suttie, D Kingsmore, T Brown, S Sultan, J Gilbert
OBJECTIVES: To describe the UK and Ireland experience of the Haemodialysis Reliable Outflow graft in complex vascular access. DESIGN: Observational, multi-centre case series. METHODS: Data from any patient undergoing Haemodialysis Reliable Outflow graft were collected from eight UK and one Irish centre. Any Haemodialysis Reliable Outflow procedure between July 2013 and May 2016 was included. Demographics, primary and secondary patency rates, and complications were analysed...
April 1, 2018: Journal of Vascular Access
https://www.readbyqxmd.com/read/29579214/temocillin-dosing-in-haemodialysis-patients-based-on-population-pharmacokinetics-of-total-and-unbound-concentrations-and-monte-carlo-simulations
#6
Ana C Miranda Bastos, Stefaan J Vandecasteele, Anne Spinewine, Paul M Tulkens, Françoise Van Bambeke
Objectives: To develop a population model describing temocillin pharmacokinetics (PK) in patients undergoing haemodialysis and investigate how pharmacokinetic/pharmacodynamic (PD) targets can be met with different dosage regimens. Patients and methods: Sixteen patients received the currently licenced dosing of 1, 2 or 3 g of temocillin (total of 61 doses) corresponding to an inter-dialytic period of 20, 44 or 68 h, respectively, and a dialysis period of 4 h...
June 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29424935/the-effect-of-extended-hours-dialysis-on-sleep-quality-in-a-randomised-trial
#7
Jin-Lan Liao, Oliver van den Broek-Best, Brendan Smyth, Daqing Hong, Kha Vo, Li Zuo, Nicholas A Gray, Christopher T Chan, Janak de Zoysa, Vlado Perkovic, Lei Jiang, Meg Jardine
BACKGROUND: Poor sleep quality is common in haemodialysis patients and associated with worse outcomes. In this pre-specified analysis, we examined the impact of extended hours haemodialysis on sleep quality. METHODS: The ACTIVE Dialysis trial randomized 200 participants to extended (≥24 hours/week) or standard (target 12-15 hours) hours haemodialysis over 12 months. Sleep quality was measured in the Kidney Disease Quality of Life Short Form 1.3 (KDQOL-SF) by overall sleep quality score (0-10, 10 = "very good") and the sleep subscale (0-100, 100 = 'best possible sleep') every three months via blinded telephone interviewer...
February 9, 2018: Nephrology
https://www.readbyqxmd.com/read/29351783/simple-citrate-anticoagulation-protocol-for-low-flux-haemodialysis
#8
Eng Kuang Lim, Ying-Ying T Seow, Shun E Chen, Gao Yang, Min Er Liaw, Shimi Isaac
BACKGROUND: For patients unable to receive heparin anticoagulation during haemodialysis, saline flushes to reduce circuit clotting are often the norm. Regional citrate anticoagulation (RCA) although effective is not used by many centres including in Singapore. We wanted to demonstrate the superiority and safety of a simple regional citrate anticoagulation regime, compared to saline flushes, for heparin-free low flux haemodialysis. METHODS: This is a prospective, open label, cross over study on 25 sequential haemodialysis sessions for inpatients receiving heparin-free haemodialysis...
January 19, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29315736/dosing-oxaliplatin-in-a-haemodialysis-patient-with-metastatic-rectum-cancer-monitored-by-free-platinum-concentrations
#9
I R F van Berlo-van de Laar, W J Brummelhuis, A L T Imholz, J H Schellens, A D R Huitema, F G A Jansman
WHAT IS KNOWN AND OBJECTIVE: Oxaliplatin in combination with fluorouracil and folinic acid is one of the preferred chemotherapeutic options in the treatment of metastatic rectum cancer. However, oxaliplatin is contraindicated in patients with a creatinine clearance <30 mL/min and dosing guidelines in patients on haemodialysis have not been established. CASE SUMMARY: A 77-year-old haemodialysis patient with metastatic rectum cancer was treated with FOLFOX and bevacizumab (oxaliplatin 70 mg/m2 , folinic acid 200 mg/m2 , 5-FU 340 mg/m2 bolus and 2040 mg/m2 continuous infusion during 44 hours and bevacizumab 5 mg/kg) every three weeks...
January 5, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29301798/enhanced-elimination-of-cyclophosphamide-by-high-cut-off-haemodialysis-single-dose-pharmacokinetics-in-a-patient-with-cast-nephropathy
#10
Gabriele Eden, W Nikolaus Kühn-Velten, Carsten Hafer, Jan T Kielstein
High cut-off (HCO) haemodialysis removes free light chains in patients with multiple myeloma. This is possible as HCO dialysers allow clearance of molecules up to a molecular weight of 65 kDa. In contrast, high-flux dialysers, which are used in routine haemodialysis, only remove molecules up to a molecular weight of 20 kDa. Even though patients with advanced myeloma frequently need dialysis and alkylating agents, drug dosing recommendations in this patient population are scarce at best or absent as for cyclophosphamide dosing in patients with myeloma undergoing HCO dialysis...
January 4, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29250808/safety-and-efficacy-of-sofosbuvir-based-treatment-of-acute-hepatitis-c-in-end-stage-renal-disease-patients-undergoing-haemodialysis
#11
Y L He, S J Yang, C H Hu, J Dong, H Gao, T T Yan, J F Liu, Y Yang, D F Ren, L Zhu, Y R Zhao, T Y Chen
BACKGROUND: Hepatitis C virus (HCV) infection in patients undergoing haemodialysis is prevalent and aggressive. The treatment of chronic hepatitis C has been revolutionised by the advent of direct-acting antivirals (DAAs). However, the safety, efficacy, and tolerance of DAAs in the treatment of acute HCV infection in patients with end-stage renal disease who are on haemodialysis are unknown. AIM: To evaluate the safety and efficacy of sofosbuvir plus daclatasvir in this specific, difficult-to-treat population...
February 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29225812/the-utility-of-whole-body-vibration-exercise-in-haemodialysis-patients-a-pilot-study
#12
Arthur Doyle, Karen Chalmers, David J Chinn, Fiona McNeill, Nicola Dall, Christopher H Grant
Background: Exercise improves physical capacity in patients with end-stage renal disease on haemodialysis (HD), but few patients engage in it. Whole-body vibration exercise (WBVE) is a novel protocol that has been shown to benefit frail elderly patients' rehabilitation. We assessed the utility of WBVE before HD sessions and tested methods to inform the design of a randomized controlled trial (RCT). Methods: Physical condition and quality of life were assessed at enrolment and repeated 2 weeks later in a pilot study of 49 patients undergoing regular HD...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29225811/regular-exercise-during-haemodialysis-promotes-an-anti-inflammatory-leucocyte-profile
#13
Maurice Dungey, Hannah M L Young, Darren R Churchward, James O Burton, Alice C Smith, Nicolette C Bishop
Background: Cardiovascular disease is the most common cause of mortality in haemodialysis (HD) patients and is highly predicted by markers of chronic inflammation. Regular exercise may have beneficial anti-inflammatory effects, but this is unclear in HD patients. This study assessed the effect of regular intradialytic exercise on soluble inflammatory factors and inflammatory leucocyte phenotypes. Methods: Twenty-two HD patients from a centre where intradialytic cycling was offered thrice weekly and 16 HD patients receiving usual care volunteered...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29139052/a-validated-patient-specific-fsi-model-for-vascular-access-in-haemodialysis
#14
A M de Villiers, A T McBride, B D Reddy, T Franz, B S Spottiswoode
The flow rate inside arteriovenous fistulas is many times higher than physiological flow and is accompanied by high wall shear stress resulting in low patency rates. A fluid-structure interaction finite element model is developed to analyse the blood flow and vessel mechanics to elucidate the mechanisms that can lead to failure. The simulations are validated against flow measurements obtained from magnetic resonance imaging data.
April 2018: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/29070834/myocardial-changes-in-incident-haemodialysis-patients-over-6-months-an-observational-cardiac-magnetic-resonance-imaging-study
#15
Elaine Rutherford, Kenneth Mangion, Christie McComb, Elizabeth Bell, Samantha Cockburn, Mohammed Talle, Giles Roditi, Paul Welsh, Rosemary Woodward, Aleksandra Radjenovic, Allan D Struthers, Alan G Jardine, Colin Berry, Rajan K Patel, Patrick B Mark
Patients commencing on haemodialysis (HD) have an increased risk of cardiovascular events in the first year after starting HD compared to those patients established on HD longer. Left ventricular (LV) hypertrophy and abnormal myocardial strain predict mortality. There may be changes in the myocardium of incident HD patients over a 6-month period of HD which may explain changes in cardiovascular risk. We used CMR to consider changes in LV mass, myocardial strain and T1 mapping. We examined changes in pre-dialysis highly sensitive troponin T...
October 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29028161/effect-of-haemodialysis-and-residual-renal-function-on-serum-levels-of-galectin-3-b-type-natriuretic-peptides-and-cardiac-troponin-t
#16
Matthew A Roberts, Piyush M Srivastava, David L Hare, Francesco L Ierino
AIM: Levels of plasma markers of myocardial fibrosis (galectin-3), stretch (B-type natriuretic peptide (BNP)) and injury (troponin T (TnT)) may be affected by haemodialysis and residual renal function (RRF) in addition to cardiac pathology. We aimed to determine the association of RRF, urine output and haemodialysis itself on clinically important cardiac biomarkers in haemodialysis patients. METHODS: Adult haemodialysis patients underwent venesection pre- and post- haemodialysis followed by echocardiography and inter-dialytic urine collection to calculate RRF (mL/minute/1...
October 13, 2017: Nephrology
https://www.readbyqxmd.com/read/28992140/inflammation-induces-osteoclast-differentiation-from-peripheral-mononuclear-cells-in-chronic-kidney-disease-patients-crosstalk-between-the-immune-and-bone-systems
#17
Cesira Cafiero, Margherita Gigante, Giacomina Brunetti, Simona Simone, Nada Chaoul, Angela Oranger, Elena Ranieri, Silvia Colucci, Giovanni B Pertosa, Maria Grano, Loreto Gesualdo
Background: Inflammation and immune system alterations contribute to bone damage in many pathologies by inducing the differentiation of osteoclasts (OCs), the bone resorbing cells. This link is largely unexplored in chronic kidney disease (CKD) and haemodialysis (HD) patients, in which reduced renal function is accompanied by an increased inflammatory state and skeletal abnormality. Methods: We used ex vivo culture experiments to investigate the osteoclastogenic potential of peripheral blood mononuclear cells (PBMCs) of CKD and HD patients, focusing on immune cell subsets and inflammatory cytokines such as LIGHT and receptor activator of nuclear factor κB ligand (RANKL)...
July 21, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28701203/discovery-of-a-novel-dominant-mutation-in-the-ren-gene-after-forty-years-of-renal-disease-a-case-report
#18
Rhian L Clissold, Helen C Clarke, Olivera Spasic-Boskovic, Kim Brugger, Stephen Abbs, Coralie Bingham, Charles Shaw-Smith
BACKGROUND: Heterozygous mutations in the gene encoding renin (REN) cause autosomal dominant tubulointerstitial kidney disease (ADTKD), early-onset anaemia and hyperuricaemia; only four different mutations have been described in the published literature to date. We report a novel dominant REN mutation discovered in an individual after forty years of renal disease. CASE PRESENTATION: A 57 year old Caucasian woman with chronic kidney disease stage five was reviewed in a regional joint renal genetics clinic...
July 12, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28666310/effectiveness-of-self-management-support-in-maintenance-haemodialysis-patients-with-hypertension-a-pilot-cluster-randomized-controlled-trial
#19
Baoyan Huang, Zheng Li, Ying Wang, Jinghua Xia, Tao Shi, Jingmei Jiang, Nolan T Marie, Xuemei Li, Sagar U Nigwekar, Limeng Chen
BACKGROUND: Uncontrolled hypertension is an independent risk factor for cardiovascular disease and is the leading cause of mortality in haemodialysis patients. The aim of this study was to examine the effectiveness of self-management support SMS) for blood pressure (BP) control and health behaviors. METHODS: We conducted a cluster randomized controlled trial (RCT) in which 90 adult haemodialysis patients were assigned to either an SMS or common intervention (CI) group...
June 30, 2017: Nephrology
https://www.readbyqxmd.com/read/28653946/the-truth-on-current-peritoneal-dialysis-state-of-the-art
#20
REVIEW
R T Krediet, A C Abrahams, C W H de Fijter, M G H Betjes, W H Boer, B C van Jaarsveld, C J A M Konings, F W Dekker
The share of peritoneal dialysis (PD) in the spectrum of chronic dialysis has decreased markedly in the Netherlands in the last 15 years. Consequently, the knowledge of nephrologists and nursing staff on PD has declined leading to a negative spiral in which loss of experience resulted in loss of enthusiasm to offer PD to patients and also in less interest in the new PD developments. All these changes took place while the results of PD improved and patient survival was at least similar to that on haemodialysis...
June 2017: Netherlands Journal of Medicine
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