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https://www.readbyqxmd.com/read/28820408/-thrombophilic-genetic-mutations-and-polymorphisms-in-women-with-infertility-and-failed-in-vitro-fertilization
#1
G Abrahamyan
Occurrence of pregnancy after in vitro fertilization depends of two components: functional adequacy of the embryo at the blastocyst stage and receptivity of endometrium, which, according to modern perception, are determinate in achieving optimal conditions of implantation. From the pregnancy occurrence point of view, as well as in regard to its further development , implantation is the most crucial phase of IVF/ICSI and ET. As the same time, this phase is also the most vulnerable. Multiple researches have proven the role of mother thrombophilia for genesis of gestation complications and early embryo losses, but in relation to this problem i the context of IVF there is still a lot to be detailed...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28807397/colorectal-endometriosis-associated-infertility-should-surgery-precede-art
#2
Sofiane Bendifallah, Horace Roman, Emmanuelle Mathieu d'Argent, Salma Touleimat, Jonathan Cohen, Emile Darai, Marcos Ballester
OBJECTIVE: To compare the impact of first-line assisted reproductive technology (ART; intracytoplasmic sperm injection [ICSI]-IVF) and first-line colorectal surgery followed by ART on fertility outcomes in women with colorectal endometriosis-associated infertility. DESIGN: Retrospective matched cohort study using propensity score (PS) matching (PSM) analysis. SETTING: University referral centers. PATIENT(S): A total of 110 women were analyzed from January 2005 to June 2014...
August 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28806905/evaluation-of-the-cervix-tissue-homogeneity-by-ultrasound-elastography-in-infertile-women-for-the-prediction-of-embryo-transfer-ease-a-diagnostic-accuracy-study
#3
Antonio Stanziano, Anna Maria Caringella, Clementina Cantatore, Giuseppe Trojano, Ettore Caroppo, Giuseppe D'Amato
BACKGROUND: Ultrasound elastography is a non-invasive medical imaging technique able to quantitatively characterize the stiffness of a given tissue. It has been shown to predict the risk for cervical insufficiency and preterm delivery, and to allow differentiation of malignancy from normal tissue. The present study sought to evaluate whether cervical tissue dishomogeneity, as assessed by cervical ultrasound elastography, may predict the embryo transfer (ET) ease in infertile women undergoing IVF/ICSI...
August 14, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28798414/comparison-of-neonatal-outcomes-following-progesterone-use-during-ovarian-stimulation-with-frozen-thawed-embryo-transfer
#4
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
Progesterone soft capsules (brand name: Utrogestan) were demonstrated to be an effective oral alternative to prevent premature LH surges both in normal-ovulatory and polycystic ovarian syndrome (PCOS) patients. However, its safety in terms of neonatal outcomes is unclear. To evaluate whether Utrogestan use increase the risk of adverse neonatal outcomes compared with short protocol in patients undergoing IVF/ICSI treatments in combination with frozen-thawed embryo transfer (FET), we performed a retrospective analysis including 1008 FET cycles, with embryos originated from either Utrogestan + hMG protocol (n = 499), or short protocol (n = 509), which led to 546 live-born infants...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28795845/analysis-of-embryo-intactness-and-developmental-potential-following-slow-freezing-and-vitrification
#5
Lan Yu, Chanwei Jia, Yonglian Lan, Rui Song, Liying Zhou, Ying Li, Yu Liang, Shuyu Wang
The aim of this study was to identify the parameters that are related to intactness and developmental potential of a day 3 embryo after warming to improve the selection criteria used to cryopreserve and transfer embryos. We also sought to compare slow freezing and vitrification methods of cryopreservation and to evaluate the viability of non-intact embryos. Embryos warmed following slow freezing (n=220) or vitrification (n=522) were divided into 3 groups according to the proportion of surviving blastomeres (I<50%; II=50-99%; and III=100%)...
August 10, 2017: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/28795049/comparison-of-clinical-outcomes-between-in-vitro-fertilization-ivf-and-intracytoplasmic-sperm-injection-icsi-in-ivf-icsi-split-insemination-cycles
#6
Sun Hee Lee, Jae Hyun Lee, Yong-Seog Park, Kwang Moon Yang, Chun Kyu Lim
OBJECTIVE: This study aimed to compare the clinical outcomes between in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) in sibling oocytes. Additionally, we evaluated whether the implementation of split insemination contributed to an increase in the number of ICSI procedures. METHODS: A total of 571 cycles in 555 couples undergoing split insemination cycles were included in this study. Among them, 512 cycles (89.7%) were a couple's first IVF cycle...
June 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28795048/evaluation-of-human-embryo-development-in-in-vitro-fertilization-and-intracytoplasmic-sperm-injection-fertilized-oocytes-a-time-lapse-study
#7
Hyung Jun Kim, Hye Jin Yoon, Jung Mi Jang, Won Don Lee, San Hyun Yoon, Jin Ho Lim
OBJECTIVE: We investigated whether the insemination method (in vitro fertilization [IVF] or intracytoplasmic sperm injection [ICSI]) affected morphokinetic events and abnormal cleavage events in embryonic development. METHODS: A total of 1,830 normal fertilized embryos were obtained from 272 IVF and ICSI cycles that underwent ovum retrieval culture using a time-lapse system (Embryoscope) from June 2013 to March 2015. All embryos were investigated by a detailed time-lapse analysis that measured the developmental events in the hours after IVF or ICSI insemination...
June 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28795047/influence-of-the-insemination-method-on-the-outcomes-of-elective-blastocyst-culture
#8
Caizhu Wang, Guixue Feng, Bo Zhang, Jinhui Shu, Hong Zhou, Xianyou Gan, Ruoyun Lin
OBJECTIVE: The aim of this study was to explore the effects of the insemination method on the outcomes of elective blastocyst culture. METHODS: We retrospectively analyzed the outcomes of elective blastocyst culture performed between January 2011 and December 2014. RESULTS: There were 2,003 cycles of conventional in vitro fertilization (IVF) and 336 cycles of intracytoplasmic sperm injection (ICSI), including 25,652 and 4,164 embryos that underwent sequential blastocyst culture, respectively...
June 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28776117/gnrh-antagonist-administered-twice-the-day-before-hcg-trigger-combined-with-a-step-down-protocol-may-prevent-ohss-in-ivf-icsi-antagonist-cycles-at-risk-for-ohss-without-affecting-the-reproductive-outcomes-a-prospective-randomized-control-trial
#9
Yannis Prapas, Konstantinos Ravanos, Stamatios Petousis, Yannis Panagiotidis, Achilleas Papatheodorou, Chrysoula Margioula-Siarkou, Assunta Iuliano, Giuseppe Gullo, Nikos Prapas
PURPOSE: The purpose this study is to investigate whether a double antagonist dose (0.25 mg/12 h) administered the day before hCG trigger is effective in preventing ovarian hyperstimulation syndrome (OHSS) in GnRH antagonist IVF/intracytoplasmic sperm injection (ICSI) cycles at risk for OHSS. METHODS: This is a prospective randomized control study, conducted from November 2012 to January 2016. A total of 194 patients undergoing a IVF/ICSI GnRH antagonist cycle that were at risk of OHSS and chose to proceed with embryo transfer and avoid cycle cancellation or embryo cryopreservation were allocated into two groups...
August 3, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28758852/dehydroepiandrosterone-supplementation-in-women-undergoing-assisted-reproductive-technology-with-poor-ovarian-response-a-prospective-case-control-study
#10
Haifa A Al-Turki
Objective The effects of dehydroepiandrosterone (DHEA) supplementation in Saudi Arabian women with poor ovarian response (POR) is presently unknown. The present study aimed to assess the benefits of DHEA supplementation in women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Methods This was a prospective case-control study involving 62 women who were diagnosed with POR and underwent IVF/ICSI between January 2012 and June 2016. The positive influence of DHEA in 34 women, compared with 28 women without supplementation, was defined as improvements in the number of oocytes retrieved, the fertilization rate, the number of grade I embryos generated and the pregnancy rate...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28732531/endometrial-scratching-in-women-with-implantation-failure-after-a-first-ivf-icsi-cycle-does-it-lead-to-a-higher-live-birth-rate-the-scratch-study-a-randomized-controlled-trial-ntr-5342
#11
RANDOMIZED CONTROLLED TRIAL
N E van Hoogenhuijze, H L Torrance, F Mol, J S E Laven, E Scheenjes, M A F Traas, C Janssen, B Cohlen, G Teklenburg, J P de Bruin, R van Oppenraaij, J W M Maas, E Moll, K Fleischer, M H van Hooff, C de Koning, A Cantineau, C B Lambalk, M Verberg, M Nijs, A P Manger, M van Rumste, L F van der Voet, A Preys-Bosman, J Visser, E Brinkhuis, J E den Hartog, A Sluijmer, F W Jansen, W Hermes, M L Bandell, M J Pelinck, J van Disseldorp, M van Wely, J Smeenk, Q D Pieterse, J C Boxmeer, E R Groenewoud, M J C Eijkemans, J C Kasius, F J M Broekmans
BACKGROUND: Success rates of assisted reproductive techniques (ART) are approximately 30%, with the most important limiting factor being embryo implantation. Mechanical endometrial injury, also called 'scratching', has been proposed to positively affect the chance of implantation after embryo transfer, but the currently available evidence is not yet conclusive. The primary aim of this study is to determine the effect of endometrial scratching prior to a second fresh in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle on live birth rates in women with a failed first IVF/ICSI cycle...
July 21, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28724477/oliver-sacks-our-correspondence-about-twins-twin-research-vanishing-twins-syndrome-discordant-sex-in-mz-twins-pregnancy-outcomes-in-ivf-and-icsi-conceived-twins-print-and-media-superfetated-twins-twins-discordant-for-smoking-twins-in-fashion-yale-university
#12
Nancy L Segal
The late neurologist and author, Oliver Sacks, published an insightful 1986 review of Marjorie Wallace's book, The Silent Twins, in the New York Times. Taking exception to his assertion about Sir Francis Galton, I wrote a letter to the Times' editor. The letter was unpublished, but it brought a wonderful response from Sacks himself that is reproduced and examined. Next, brief reviews of twin research concerning the vanishing twin syndrome (VTS), discordant sex in a monozygotic (MZ) twin pair, and multiple pregnancy outcomes from assisted reproductive technology (ART) are presented...
August 2017: Twin Research and Human Genetics: the Official Journal of the International Society for Twin Studies
https://www.readbyqxmd.com/read/28718082/low-first-trimester-papp-a-in-ivf-fresh-and-frozen-thawed-pregnancies-likely-due-to-a-biological-cause
#13
Lauren P Hunt, A M McInerney-Leo, S Sinnott, B Sutton, R Cincotta, G Duncombe, J Chua, M Peterson
PURPOSE: The purpose of this study is to confirm a difference in the first-trimester screen maternal biochemistry and false-positive rates (FPR) between pregnancies conceived spontaneously and those conceived via assisted reproductive technologies (ART). METHODS: Retrospective analysis of the complete population of women (17,889 pregnancies) who had undergone first-trimester screening between January 2004 and September 2009 at three private ultrasound clinics in Queensland, Australia was used in the study...
July 17, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28715980/clinical-aspects-of-infertile-47-xyy-patients-a-retrospective-study
#14
Parnaz Borjian Boroujeni, Marjan Sabbaghian, Ahmad Vosough Dizaji, Shabnam Zarei Moradi, Navid Almadani, Faranak Mohammadpour Lashkari, Mohamad Reza Zamanian, Anahita Mohseni Meybodi
47,XYY syndrome is a sex chromosomal anomaly in men, which may be associated with infertility and has an incidence of 0.1% of male births. The clinical and paraclinical characteristics of men suffering from this anomaly have not been fully described. In this retrospective study, we present 37 cases of 47,XYY infertile men with sperm counts varying from normal to azoospermia, referred to the Genetics Laboratory at the Royan Institute, Iran. Thirteen individuals were mosaic and 24 non-mosaics. Non-mosaic patients were classified as azoospermic (nine cases) and normospermic/oligozoospermic men (15 cases)...
July 18, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28706366/gnrh-antagonist-cetrorelix-administration-before-hcg-for-protection-of-ovarian-hyperstimulation-syndrome
#15
Sherif A Hebisha, Banan A Aboelazm, H N Sallam
OBJECTIVE: Studying the effect of GnRH antagonist administration on the day of hCG to cases of IVF/ICSI with estradiol level above 5000 ng/dl for protection of ovarian hyperstimulation syndrome. DESIGN: Prospective study. MATERIALS AND METHODS: Sixty patients undergoing controlled hyperstimulation COH, for IVF/ICSI using long agonist and E2 level on the day of hCG, are above 5000 ng/dl, 52 patients received single dose of cetrorelix 0.25 mg on the day of hCG, and 8 patients received two doses of 0...
August 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28697910/duphaston-and-human-menopausal-gonadotropin-protocol-in-normally-ovulatory-women-undergoing-controlled-ovarian-hyperstimulation-during-in%C3%A2-vitro-fertilization-intracytoplasmic-sperm-injection-treatments-in-combination-with-embryo-cryopreservation
#16
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
OBJECTIVE: To evaluate endocrine characteristics and clinical outcomes in normal ovulatory patients undergoing controlled ovarian hyperstimulation (COH) with the use of a Duphaston and hMG protocol during in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments in combination with frozen-thawed embryo transfer (FET) compared with the characteristics and outcomes of patients undergoing an Utrogestan and hMG protocol. DESIGN: Prospective controlled study...
July 8, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28697346/-necrozoospermia-from-etiologic-diagnosis-to-therapeutic-management
#17
A Dumont, A-L Barbotin, V Lefebvre-Khalil, V Mitchell, J-M Rigot, F Boitrelle, G Robin
This review describes necrospermia, its diagnosis, causes and management. Sperm vitality is commonly assessed in the laboratory of reproductive biology, with the eosin test or with the hypo-osmotic swelling test. Necrospermia is defined by a percentage of living spermatozoa inferior to 58%, and can be related to male infertility. Several pathological mechanisms may be involved and can be classified either in testicular causes (hyperthyroidism, local hyperthermia, varicocele), or post-testicular causes (epididymal necrospermia, dysregulation of seminal plasma, adult polycystic kidney disease, vasectomy reversal, anti-sperm antibodies) or both (infection, toxic, age, spinal cord injury)...
April 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28687208/assisted-reproduction-techniques-in-latin-america-the-latin-american-registry-2014
#18
Fernando Zegers-Hochschild, Juan Enrique Schwarze, Javier Crosby, Carolina Musri, Maria Teresa Urbina
Multinational data on assisted reproduction techniques (IVF and intractytoplasmic sperm injection [ICSI], frozen embryo transfer, oocyte donation, preimplantation genetic diagnosis and fertility preservation) were collected from 159 institutions in 15 Latin American countries. A total of 41.34% of IVF-ICSI cycles were conducted in women aged 35-39 years and 23.35% in women aged 40 years and older. After removing freeze-all cases, delivery rate per oocyte retrieval was 25.05% for ICSI and 27.41% for IVF. Multiple births included 20...
September 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28675921/cycle-regimens-for-frozen-thawed-embryo-transfer
#19
REVIEW
Tarek Ghobara, Tarek A Gelbaya, Reuben Olugbenga Ayeleke
BACKGROUND: Among subfertile couples undergoing assisted reproductive technology (ART), pregnancy rates following frozen-thawed embryo transfer (FET) treatment cycles have historically been found to be lower than following embryo transfer undertaken two to five days following oocyte retrieval. Nevertheless, FET increases the cumulative pregnancy rate, reduces cost, is relatively simple to undertake and can be accomplished in a shorter time period than repeated in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) cycles with fresh embryo transfer...
July 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28674785/follicular-sensitivity-index-fsi-a-novel-tool-to-predict-clinical-pregnancy-rate-in-ivf-icsi-cycles
#20
AbdelGany M A Hassan, Mohamed M M Kotb, Ahmed M A AwadAllah, Nesreen A A Shehata, Amr Wahba
PURPOSE: This study aims to introduce a new tool (the Follicular Sensitivity Index; FSI) for objective assessment of follicular responsiveness to exogenous gonadotropins and to evaluate its ability to predict the clinical pregnancy rate in women with unexplained infertility or tubal factor undergoing IVF/ICSI. METHODS: FSI was calculated as preovulatory follicle count (PFC) × 100,000/[antral follicle count (AFC) × total received FSH doses]. One thousand women were included and were divided according to the FSI tertile values into three groups...
July 3, 2017: Journal of Assisted Reproduction and Genetics
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