keyword
MENU ▼
Read by QxMD icon Read
search

Wambui

keyword
https://www.readbyqxmd.com/read/29079186/investigating-the-association-between-african-spontaneously-fermented-dairy-products-faecal-carriage-of-streptococcus-infantarius-subsp-infantarius-and-colorectal-adenocarcinoma-in-kenya
#1
Dasel W M Kaindi, Wambui Kogi-Makau, Godfrey N Lule, Bernd Kreikemeyer, Pierre Renault, Bassirou Bonfoh, Esther Schelling, Jakob Zinsstag, Christophe Lacroix, Leo Meile, Christoph Jans, Jan Hattendorf
Consumption of traditional fermented dairy products (tFDP) in Africa leads to the ingestion of up to 10(8)Streptococcus infantarius subspecies infantarius (Sii) per millilitre of spontaneously fermented milk. Sii is a member of the Streptococcus bovis/Streptococcus equinus complex (SBSEC) for which some members are associated particularly with colorectal cancer or endocarditis. The extent of health risks to tFDP consumers is largely unknown. A hospital-based unmatched case-control study was conducted at Kenyatta National Hospital, Nairobi (Kenya) on 80 cases and 193 controls that were selected exhaustively from patients attending colonoscopy at the hospital...
October 25, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29074386/unlike-th1-th17%C3%A2-cells-th2-th9-cells-selectively-migrate-to-the-limbus-conjunctiva-and-initiate-an-eosinophilic-infiltration-process
#2
Cuiyan Tan, Wambui S Wandu, Anthony St Leger, Jennifer Kielczewski, Eric F Wawrousek, Chi-Chao Chan, Igal Gery
In this study we compared polarized mouse T-helper (Th) lymphocytes of four populations, sensitized against an ocular antigen, for their patterns of migration and induction of inflammatory processes in recipient mouse eyes expressing the target antigen. Th1, Th2, Th9 and Th17 cells transgenically expressing T-cell receptor (TCR) specific against hen egg lysozyme (HEL) were adoptively transferred to recipient mice expressing HEL in their eyes. Recipient eyes collected 4 or 7 days post injection were analyzed for histopathological changes...
October 24, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28991040/associations-of-muscle-mass-and-strength-with-all-cause-mortality-among-us-older-adults
#3
Ran Li, Jin Xia, Xi Zhang, Wambui Grace Gathirua-Mwangi, Jianjun Guo, Yufeng Li, Steve McKenzie, Yiqing Song
INTRODUCTION: Recent studies suggested that muscle mass and muscle strength may independently or synergistically affect aging-related health outcomes in older adults; however, prospective data on mortality in the general population are sparse. METHODS: We aimed to prospectively examine individual and joint associations of low muscle mass and low muscle strength with all-cause mortality in a nationally representative sample. This study included 4,449 participants aged 50 years and older from the National Health and Nutrition Examination Survey (NHANES) 1999-2002 with public-use 2011 linked mortality files...
October 4, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28983748/changes-in-adult-bmi-and-waist-circumference-are-associated-with-increased-risk-of-advanced-colorectal-neoplasia
#4
Wambui G Gathirua-Mwangi, Patrick Monahan, Yiqing Song, Terrell W Zollinger, Victoria L Champion, Timothy E Stump, Thomas F Imperiale
BACKGROUND: Waist circumference (WC) is a stronger predictor of colon cancer (CRC) risk than body mass index (BMI). However, how well change in either WC or BMI predicts risk of advanced colorectal neoplasia (AN) is unclear. AIMS: To determine the relationship between change in BMI and WC from early adulthood to later age and the risk of AN and which change measure is a stronger predictor. METHODS: In 4500 adults, ages 50-80, with no previous neoplasia and undergoing screening colonoscopy, BMI and WC at age 21 and at time of screening were reported...
November 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28951987/ethnicity-and-breast-cancer-characteristics-in-kenya
#5
Shahin Sayed, Zahir Moloo, Ronald Wasike, Peter Bird, Raymond Oigara, Faith Wambui Njoroge, Asim Jamal Shaikh, Satya Vara Prasad, Sudhir Vinayak, Gretchen L Gierach, Sanford M Dawsey, Maya Palakal, Shaoqi Fan, Maeve Mullooly, Rajendra Chauhan, Patricia Okiro, Samuel Gakinya, Ancent Nzioka, Catherine Kyobutungi, Shukri Mohamed, Tilahun Haregu, Mustafa Mussajee, Betty Bonass, Costa Mariwa, Omar Ali Sherman, Abdihakim Mohammed, Andrew Gachii, Joseph Githaiga, Joseph Karanu, Robert Nyagah, Richard Njoroge, Irene Muramba, James Obondi Otieno, Dan Omondi Raburu, Elizabeth B Mwachiro, Innocent Abayo, Mansoor Saleh
PURPOSE: There are no published data from specific regions of sub-Saharan Africa describing the clinical and pathological characteristics and molecular subtypes of invasive breast cancer by ethnic group. The purpose of this study was to investigate these characteristics among the three major ethno-cultural groupings in Kenya. METHODS: The study included women with pathologically confirmed breast cancer diagnosed between March 2012 and May 2015 at 11 hospitals throughout Kenya...
September 26, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28946854/cervical-precancerous-changes-and-selected-cervical-microbial-infections-kiambu-county-kenya-2014-a-cross-sectional-study
#6
Evalyne Wambui Kanyina, Lucy Kamau, Margaret Muturi
BACKGROUND: Cervical cancer is the predominant cancer among women in Kenya and second most common in women in developing regions. Population-based cytological screening and early treatment reduces morbidity and mortality associated with the cancer. We determined the occurrence of cervical precancerous changes and cervical microbial infections (Trichomonas vaginalis, Candida albicans, Neisseria gonorrhea and Actinomyces) among women attending Family Health Option Kenya (FHOK) clinic in Thika...
September 25, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28706941/application-of-response-surface-methodology-to-study-the-effects-of-brisket-fat-soy-protein-isolate-and-cornstarch-on-nutritional-and-textural-properties-of-rabbit-sausages
#7
Joseph M Wambui, Edward G Karuri, Margaret M M Wanyoike
The effects of brisket fat, soy protein isolate, and cornstarch on chemical and textural properties of rabbit sausages were studied using surface response methodology. Sausage samples were prepared using a five-level three-variable Central Composite Rotatable Design with 16 combinations, including two replicates of the center point, carried out in random order. The level of brisket fat (BF), soy protein isolate (SPI), and cornstarch (CS) in the sausage formulation ranged within 8.3-16.7%, 0.7-2.3%, and 1.3-4...
2017: International journal of food science
https://www.readbyqxmd.com/read/28364623/african-fermented-dairy-products-overview-of-predominant-technologically-important-microorganisms-focusing-on-african-streptococcus-infantarius-variants-and-potential-future-applications-for-enhanced-food-safety-and-security
#8
REVIEW
Christoph Jans, Leo Meile, Dasel Wambua Mulwa Kaindi, Wambui Kogi-Makau, Peter Lamuka, Pierre Renault, Bernd Kreikemeyer, Christophe Lacroix, Jan Hattendorf, Jakob Zinsstag, Esther Schelling, Gilbert Fokou, Bassirou Bonfoh
Milk is a major source of nutrients, but can also be a vehicle for zoonotic foodborne diseases, especially when raw milk is consumed. In Africa, poor processing and storage conditions contribute to contamination, outgrowth and transmission of pathogens, which lead to spoilage, reduced food safety and security. Fermentation helps mitigate the impact of poor handling and storage conditions by enhancing shelf life and food safety. Traditionally-fermented sour milk products are culturally accepted and widely distributed in Africa, and rely on product-specific microbiota responsible for aroma, flavor and texture...
June 5, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28097473/metabolic-syndrome-and-total-cancer-mortality-in-the-third-national-health-and-nutrition-examination-survey
#9
Wambui G Gathirua-Mwangi, Patrick O Monahan, Mwangi J Murage, Jianjun Zhang
PURPOSE: Although metabolic syndrome incidence has substantially increased during the last few decades, it largely remains unclear whether this metabolic disorder is associated with total cancer mortality. The present study was carried out to investigate this important question. METHODS: A total of 687 cancer deaths were identified from 14,916 participants in the third National Health and Nutrition Examination Survey by linking them to the National Death Index database through December 31, 2006...
February 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27986906/shedding-new-light-on-the-process-of-licensing-for-pathogenicity-by-th-lymphocytes
#10
Cuiyan Tan, Wambui S Wandu, R Steven Lee, Samuel H Hinshaw, Dennis M Klinman, Eric Wawrousek, Igal Gery
Th cells sensitized against autoantigens acquire pathogenicity following two sequential events, namely activation by their target Ag and a process named "licensing." In this study, we analyzed these processes in a transgenic mouse system in which TCR-transgenic Th cells specific to hen egg lysozyme (HEL) are adoptively transferred to recipients and induce inflammation in eyes expressing HEL. Our data show that the notion that the lung is the organ where "licensing" for pathogenicity takes place is based on biased data collected with cells injected i...
January 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27918845/application-of-probabilistic-modeling-to-quantify-the-reduction-levels-of-hepatocellular-carcinoma-risk-attributable-to-chronic-aflatoxins-exposure
#11
Joseph M Wambui, Edward G Karuri, Julia A Ojiambo, Patrick M K Njage
Epidemiological studies show a definite connection between areas of high aflatoxin content and a high occurrence of human hepatocellular carcinoma (HCC). Hepatitis B virus in individuals further increases the risk of HCC. The two risk factors are prevalent in rural Kenya and continuously predispose the rural populations to HCC. A quantitative cancer risk assessment therefore quantified the levels at which potential pre- and postharvest interventions reduce the HCC risk attributable to consumption of contaminated maize and groundnuts...
January 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/27906029/trends-in-clinical-characteristics-and-outcomes-of-pre-art-care-at-a-large-hiv-clinic-in-nairobi-kenya-a-retrospective-cohort-study
#12
Jared O Mecha, Elizabeth N Kubo, Lucy W Nganga, Peter N Muiruri, Lilian N Njagi, Immaculate N Mutisya, Justine J Odionyi, Syokau C Ilovi, Mary Wambui, Christopher Githu, Richard Ngethe, Elizabeth M Obimbo, Zipporah W Ngumi
BACKGROUND: The success of antiretroviral therapy in resource-scarce settings is an illustration that complex healthcare interventions can be successfully delivered even in fragile health systems. Documenting the success factors in the scale-up of HIV care and treatment in resource constrained settings will enable health systems to prepare for changing population health needs. This study describes changing demographic and clinical characteristics of adult pre-ART cohorts, and identifies predictors of pre-ART attrition at a large urban HIV clinic in Nairobi, Kenya...
November 14, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27895697/trends-in-clinical-characteristics-and-outcomes-of-pre-art-care-at-a-large-hiv-clinic-in-nairobi-kenya-a-retrospective-cohort-study
#13
Jared O Mecha, Elizabeth N Kubo, Lucy W Nganga, Peter N Muiruri, Lilian N Njagi, Immaculate N Mutisya, Justine J Odionyi, Syokau C Ilovi, Mary Wambui, Christopher Githu, Richard Ngethe, Elizabeth M Obimbo, Zipporah W Ngumi
BACKGROUND: The success of antiretroviral therapy in resource-scarce settings is an illustration that complex healthcare interventions can be successfully delivered even in fragile health systems. Documenting the success factors in the scale-up of HIV care and treatment in resource constrained settings will enable health systems to prepare for changing population health needs. This study describes changing demographic and clinical characteristics of adult pre-ART cohorts, and identifies predictors of pre-ART attrition at a large urban HIV clinic in Nairobi, Kenya...
2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27823100/managing-encephalitis
#14
Hellen Wambui
What was the nature of the CPD activity, practice-related feedback and/or event and/or experience in your practice? The CPD article provided an overview of the signs and symptoms of encephalitis, and the treatment and management of this condition. It also discussed the different aspects of nursing care required for these patients.
October 5, 2016: Nursing Standard
https://www.readbyqxmd.com/read/27660116/the-effect-of-declining-exposure-on-t-cell-mediated-immunity-to-plasmodium-falciparum-an-epidemiological-natural-experiment
#15
Yaw Bediako, Joyce Mwongeli Ngoi, George Nyangweso, Juliana Wambua, Michael Opiyo, Eunice Wambui Nduati, Philip Bejon, Kevin Marsh, Francis Maina Ndungu
BACKGROUND: Naturally acquired immunity to malaria may be lost with lack of exposure. Recent heterogeneous reductions in transmission in parts of Africa mean that large populations of previously protected people may lose their immunity while remaining at risk of infection. METHODS: Using two ethnically similar long-term cohorts of children with historically similar levels of exposure to Plasmodium falciparum who now experience very different levels of exposure, we assessed the effect of decreased parasite exposure on antimalarial immunity...
September 22, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27386244/effect-of-water-stress-on-growth-of-three-linseed-linum-usitatissimum-l-varieties
#16
Lilian Wambui Kariuki, Peter Masinde, Stephen Githiri, Arnold N Onyango
Linseed (Linum usitatissimum L.) is an annual oil crop that accounts for approximately 1 % of the world's oilseed supplies. It produces seeds that are rich in the health-promoting ω-3 fatty acid, α-linolenic. In Kenya, linseed is grown in the Rift Valley and Western regions, places which often experience drought. This study was aimed at evaluating the effect of water stress on growth of three linseed cultivars and to establish the extent of drought tolerance in the three cultivars. A greenhouse pot experiment in a completely randomized design was conducted at Jomo Kenyatta University of Agriculture and Technology, Kenya...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27329036/phylogenetic-epidemiological-and-functional-analyses-of-the-streptococcus-bovis-streptococcus-equinus-complex-through-an-overarching-mlst-scheme
#17
Christoph Jans, Tomas de Wouters, Bassirou Bonfoh, Christophe Lacroix, Dasel Wambua Mulwa Kaindi, Janine Anderegg, Désirée Böck, Sabrina Vitali, Thomas Schmid, Julia Isenring, Fabienne Kurt, Wambui Kogi-Makau, Leo Meile
BACKGROUND: The Streptococcus bovis/Streptococcus equinus complex (SBSEC) comprises seven (sub)species classified as human and animal commensals, emerging opportunistic pathogens and food fermentative organisms. Changing taxonomy, shared habitats, natural competence and evidence for horizontal gene transfer pose difficulties for determining their phylogeny, epidemiology and virulence mechanisms. Thus, novel phylogenetic and functional classifications are required. An SBSEC overarching multi locus sequence type (MLST) scheme targeting 10 housekeeping genes was developed, validated and combined with host-related properties of adhesion to extracellular matrix proteins (ECM), activation of the immune responses via NF-KB and survival in simulated gastric juice (SGJ)...
June 21, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27159353/research-progress-in-phytochemistry-and-biology-of-aframomum-species
#18
REVIEW
Sarah Wambui Amadi, Yan Zhang, Guanzhong Wu
CONTEXT: The African genus Aframomum (Zingiberaceae) is a group of diverse tropical plants frequently collected yet largely neglected taxonomically. The current and unprecedented loss of species due to man-made habitat destruction and climate change adds a desperate urgency not only to understand the phylogenetics, chemotaxonomy and biology, but also to preserve the quickly disappearing species. OBJECTIVES: The present systematic review reports on the research progress in phytochemistry, pharmacology and toxicology of Aframomum species...
November 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27028065/digoxin-inhibits-induction-of-experimental-autoimmune-uveitis-in-mice-but-causes-severe-retinal-degeneration
#19
Samuel J H Hinshaw, Osato Ogbeifun, Wambui S Wandu, Cancan Lyu, Guangpu Shi, Yichao Li, Haohua Qian, Igal Gery
PURPOSE: Digoxin, a major medication for heart disease, was recently reported to have immunosuppressive capacity. Here, we determined the immunosuppressive capacity of digoxin on the development of experimental autoimmune uveitis (EAU) and on related immune responses. METHODS: The B10.A mice were immunized with interphotoreceptor retinoid-binding protein (IRBP) and were treated daily with digoxin or vehicle control. On postimmunization day 14, the mouse eyes were examined histologically, while spleen cells were tested for cytokine production in response to IRBP and purified protein derivative...
March 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/26911274/hydroxychloroquine-in-patients-with-systemic-lupus-erythematosus-with-end-stage-renal-disease
#20
Monique Bethel, Frances M Yang, Shuang Li, N Stanley Nahman, Alyce M Oliver, Wambui Machua, Laura D Carbone
OBJECTIVES: To determine dosing patterns and examine predictors of filled hydroxychloroquine (HCQ) prescriptions in patients with systemic lupus erythematosus (SLE) with end-stage renal disease (ESRD). METHODS: This was a retrospective cohort study of patients with SLE in the US Renal Data System (USRDS) database in fiscal year 2011. All patients were Medicare Part D beneficiaries. Patients with a diagnosis of SLE were identified by the International Classification of Diseases, 9th revision code 710...
April 2016: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
keyword
keyword
51755
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"