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Rebecca J Brown, David Araujo-Vilar, Pik To Cheung, David Dunger, Abhimanyu Garg, Michelle Jack, Lucy Mungai, Elif A Oral, Nivedita Patni, Kristina Rother, Julia von Schnurbein, Ekaterina Sorkina, Takara Stanley, Corinne Vigouroux, Martin Wabitsch, Rachel Williams, Tohru Yorifuji
OBJECTIVE: Lipodystrophy syndromes are extremely rare disorders of deficient body fat associated with potentially serious metabolic complications, including diabetes, hypertriglyceridemia, and steatohepatitis. Due to their rarity, most clinicians are not familiar with their diagnosis and management. This practice guideline summarizes diagnosis and management of lipodystrophy syndromes not associated with HIV or injectable drugs. PARTICIPANTS: Seventeen participants were nominated by worldwide endocrine societies or selected by the committee as content experts...
October 6, 2016: Journal of Clinical Endocrinology and Metabolism
Cynthia J Musante, Saroja Ramanujan, Brian J Schmidt, Oliver G Ghobrial, James Lu, Astra Zeneca, Anne C Heatherington
No abstract text is available yet for this article.
October 6, 2016: Clinical Pharmacology and Therapeutics
John Reynolds, David Ray, M Yvonne Alexander, Ian Bruce
BACKGROUND: Patients with systemic lupus erythematosus (SLE) have endothelial dysfunction and increased risk of cardiovascular disease. Endothelium-dependent dilatation (ED) is abnormal in patients with SLE, and endothelial repair mechanisms are also impaired. Myeloid angiogenic cells (MACs) promote angiogenesis to restore damaged vessels. Vitamin D deficiency is associated with cardiovascular disease in the general population and is prevalent in SLE. We aimed to assess the effect of vitamin D on endothelial repair and function...
February 26, 2015: Lancet
Hongying Kuang, Susan Jin, Karl R Hansen, Michael P Diamond, Christos Coutifaris, Peter Casson, Gregory Christman, Ruben Alvero, Hao Huang, G Wright Bates, Rebecca Usadi, Scott Lucidi, Valerie Baker, Nanette Santoro, Esther Eisenberg, Richard S Legro, Heping Zhang
STUDY QUESTION: Can we build and validate predictive models for ovulation and pregnancy outcomes in infertile women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: We were able to develop and validate a predictive model for pregnancy outcomes in women with PCOS using simple clinical and biochemical criteria particularly duration of attempting conception, which was the most consistent predictor among all considered factors for pregnancy outcomes. WHAT IS KNOWN ALREADY: Predictive models for ovulation and pregnancy outcomes in infertile women with polycystic ovary syndrome have been reported, but such models require validation...
September 2015: Human Reproduction
Hari Shanker Sharma, Eugene A Kiyatkin, Ranjana Patnaik, José Vicente Lafuente, Dafin F Muresanu, Per-Ove Sjöquist, Aruna Sharma
In this study, we examined the influence of cold and hot environments on methamphetamine (METH) neurotoxicity in both drug-naive rats and animals previously exposed to different types of nanoparticles (NPs). Since METH induces oxidative stress, we also examined how a potential chain-breaking antioxidant H-290/51 (Astra-Zeneca, Mölndal, Sweden) affects METH-induced neurotoxicity. Exposure of drug-naive rats to METH (9 mg/kg, s.c.) at 4, 21, or 34 °C for 3 h resulted in breakdown of the blood-brain barrier (BBB), brain edema, and neuronal injuries, which all differed in severity depending upon ambient temperatures...
October 2015: Molecular Neurobiology
Adriano Henney, Hannah Coaker
Adriano Henney speaks to Hannah Coaker, Commissioning Editor. After achieving a PhD in medicine and spending many years in academic research in the field of cardiovascular disease, Adriano Henney was recruited by Zeneca Pharmaceuticals from a British Heart Foundation Senior Fellowship, where he led the exploration of new therapeutic approaches in atherosclerosis, specifically focusing on his research interests in vascular biology. Following the merger with Astra to form AstraZeneca, Henney became responsible for exploring strategic improvements to the company's approaches to pharmaceutical target identification and the reduction of attrition in early development, directing projects across research sites and across functional project teams in the USA, Sweden and the UK...
2014: Future Medicinal Chemistry
Helgo Magnussen, Bernd Disse, Roberto Rodriguez-Roisin, Anne Kirsten, Henrik Watz, Kay Tetzlaff, Lesley Towse, Helen Finnigan, Ronald Dahl, Marc Decramer, Pascal Chanez, Emiel Wouters, Peter Calverley
SESSION TITLE: COPD TreatmentSESSION TYPE: Original Investigation SlidePRESENTED ON: Sunday, October 26, 2014 at 01:30 PM - 03:00 PMPURPOSE: The WISDOM study demonstrated ICS may be successfully withdrawn in patients receiving LAMA+LABA without significantly increasing COPD exacerbation risk (Chest 2014). We report change in FEV1 and symptoms.METHODS: All patients in the 12-month, double-blind, parallel-group, active-controlled WISDOM study (NCT00975195) received triple therapy (tiotropium 18 µg QD, salmeterol 50 µg BID, and fluticasone 500 µg BID) for a 6-week run-in period...
October 1, 2014: Chest
Stephen Rennard, Gary Ferguson, Edward Kerwin, Ludmyla Rekeda, Esther Garcia Gil
SESSION TITLE: COPD LAMA/LABASESSION TYPE Original Investigation SlidePRESENTED ON: Monday, October 27, 2014 at 01:30 PM - 02:30 PMPURPOSE: To assess long-term safety and efficacy of aclidinium bromide (AB) in moderate to severe COPD patients.METHODS: In this open-label, 40-week extension study, patients completing a 12-week double-blind lead-in trial (ACCORD II) were transitioned from randomized treatment (twice-daily [BID] placebo [PBO], AB 200µg, or AB 400µg) to AB 400µg BID. Safety, the primary outcome, was assessed via adverse events (AEs) of new or increased intensity during this extension study...
October 1, 2014: Chest
Roland Buhl, Roger Abrahams, Leif Bjermer, Eric Derom, Matjaz Flezar, Jacques Hébert, Anthony Veale, Lars Groenke, Kay Tetzlaff, Lawrence Korducki, Holger Huisman, Stella Waitere-Wijker, Lorcan McGarvey
COPD Treatment PostersSESSION TYPE: Original Investigation PosterPRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PMPURPOSE: Tiotropium, a long-acting muscarinic antagonist, has recently been assessed in fixed-dose combination (FDC) with olodaterol, a once-daily, long-acting β2-agonist, for treatment of chronic obstructive pulmonary disease (COPD). We present pooled safety data from two pivotal, replicate, Phase III studies assessing efficacy and safety of FDCs of tiotropium and olodaterol(T+O) delivered via Respimat® inhaler in patients with GOLD stage 2-4 COPD...
October 1, 2014: Chest
Florin Mihaltan, Dragos Ungureanu
SESSION TITLE: COPD Diagnosis and Evaluation Posters IISESSION TYPE: Original Investigation PosterPRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PMPURPOSE: Patient-perceived COPD symptoms vary over the day and the week with impact on daily activities, morning being the worst time of day. The study aimed to identify the correlation between patient perceptions of their ability to perform morning activities and the general health status visual scale, as assessed by the physician during physical examination...
October 1, 2014: Chest
Thomas Siler, Edward Kerwin, Ana Sousa, Alison Donald, Rehan Ali, Alison Church
Late-Breaking AbstractsSESSION TYPE: Original Investigation SlidePRESENTED ON: Tuesday, October 28, 2014 at 08:45 AM - 10:00 AMPURPOSE: Umeclidinium (UMEC) is a long-acting muscarinic antagonist approved in the US and EU for maintenance treatment of chronic obstructive pulmonary disease (COPD). Fluticasone furoate/vilanterol (FF/VI; combination inhaled corticosteroid [ICS] + long-acting beta2 agonist [LABA]) is indicated for long-term, once-daily maintenance treatment of airflow obstruction in COPD. These two replicate studies evaluated efficacy and safety of UMEC added to FF/VI in patients with COPD...
October 1, 2014: Chest
Gary W K Wong, Bert Brunekreef, Philippa Ellwood, H Ross Anderson, M Innes Asher, Julian Crane, Christopher K W Lai
BACKGROUND: Indoor air pollution from a range of household cooking fuels has been implicated in the development and exacerbation of respiratory diseases. In both rich and poor countries, the effects of cooking fuels on asthma and allergies in childhood are unclear. We investigated the association between asthma and the use of a range of cooking fuels around the world. METHODS: For phase three of the International Study of Asthma and Allergies in Childhood (ISAAC), written questionnaires were self-completed at school by secondary school students aged 13-14 years, 244,734 (78%) of whom were then shown a video questionnaire on wheezing symptoms...
July 2013: Lancet Respiratory Medicine
Gwenaelle Gravis, Patricia Marino, Florence Joly, Stéphane Oudard, Franck Priou, Benjamin Esterni, Igor Latorzeff, Remy Delva, Ivan Krakowski, Brigitte Laguerre, Fréderic Rolland, Christine Théodore, Gael Deplanque, Jean Marc Ferrero, Damien Pouessel, Loïc Mourey, Philippe Beuzeboc, Sylvie Zanetta, Muriel Habibian, Jean François Berdah, Jerome Dauba, Marjorie Baciuchka, Christian Platini, Claude Linassier, Jean Luc Labourey, Jean Pascal Machiels, Claude El Kouri, Alain Ravaud, Etienne Suc, Jean Christophe Eymard, Ali Hasbini, Guilhem Bousquet, Michel Soulie, Karim Fizazi
BACKGROUND: Toxicity, which is a key parameter in the evaluation of cancer treatments, can be underestimated by clinicians. We investigated differences between patients and physicians in reporting adverse events of androgen deprivation therapy (ADT) with or without docetaxel in a multicentre phase III trial in non-castrate metastatic prostate cancer. METHODS: The 385 patients included were invited to complete a 26-symptom questionnaire 3 and 6 months after the start of treatment, among which eighteen symptoms were also assessed by physicians, reported in medical records and graded using the Common Toxicity Criteria of the National Cancer Institute...
March 2014: European Journal of Cancer
Morgan Le Guen, Stanislas Grassin-Delyle, Camille Cornet, Antoine Genty, Thierry Chazot, Dominique Dardelle, Ngai Liu, Jean-François Dreyfus, Jean-Xavier Mazoit, Philippe Devillier, Jean-Claude Alvarez, Daniel I Sessler, Marc Fischler
BACKGROUND: Several commercial formulations of propofol are available. The primary outcome of this study was the required dose of propofol alone or combined with lidocaine to achieve induction of general anesthesia. METHODS: This multicenter, double-blinded trial randomized patients (American Society of Anesthesiologists physical status I-III) just before elective surgery with the use of a computer-generated list. Three different propofol 1% formulations-Diprivan (Astra-Zeneca, Cheshire, United Kingdom), Propoven (Fresenius-Kabi AG, Bad Homburg, Germany), and Lipuro (B-Braun, Melshungen AG, Germany)-were compared with either placebo (saline solution) or lidocaine 1% mixed to the propofol solution...
February 2014: Anesthesiology
Nicola Hanania, Jill Karpel, Udo-Michael Goehring, Manja Brose, Dirk Bredenbroker, Hassan Lakkis, Paul Rowe, Leonardo Fabbri
SESSION TYPE: COPD: Safety and Effectiveness of Newer TherapiesPRESENTED ON: Tuesday, October 23, 2012 at 02:45 PM - 04:15 PMPURPOSE: Roflumilast is approved to reduce the risk of exacerbations in patients with severe COPD associated with chronic bronchitis and a history of exacerbations. Improvement in lung function has also been noted with roflumilast treatment. This analysis examined changes in lung function among COPD subjects from a pool of seven 6-month roflumilast studies.METHODS: Data were pooled from seven 6-month randomized, placebo-controlled studies in subjects with moderate-to-severe COPD treated with roflumilast 500μg...
October 1, 2012: Chest
Lucie Blais, Fatima-Zohra Kettani, Amélie Forget
STUDY QUESTION: Are women with asthma, and more specifically those with severe or uncontrolled asthma, at higher risk of spontaneous and induced abortions? SUMMARY ANSWER: Pregnant women with asthma, notably when uncontrolled, are at higher risk of spontaneous abortion. WHAT IS KNOWN ALREADY: Only one study has examined the association between asthma and spontaneous and induced abortions and revealed a modest increase in the risk of spontaneous abortions, particularly in women with more severe asthma and those with previous exacerbations, and a marginal decrease in the risk of induced abortions...
April 2013: Human Reproduction
Nils Degrauwe, Julie Ann Sosa, Sanziana Roman, Hari A Deshpande
Medullary thyroid cancer (MTC) represents an aggressive form of thyroid malignancy. Some may occur spontaneously or can be associated with Multiple Endocrine Neoplasia syndromes, or Familial Medullary Thyroid Cancer syndrome. In these patients, the protooncogene RET (rearranged during transfection) is mutated. In patients who have unresectable or metastatic disease, the long term prognosis is poor. New treatments for this disease have focused on the use of targeted agents that inhibit the receptor tyrosine kinase of RET...
2012: Clinical Medicine Insights. Oncology
Radhika Iyer, Carly R Varela, Jane E Minturn, Ruth Ho, Anisha M Simpson, Jennifer E Light, Audrey E Evans, Huaqing Zhao, Kenneth Thress, Jeffrey L Brown, Garrett M Brodeur
Neuroblastoma is a common pediatric tumor characterized by clinical heterogeneity. Because it is derived from sympathetic neuroblasts, the NTRK family of neurotrophin receptors plays an integral role in neuroblastoma cell survival, growth, and differentiation. Indeed, high expression of NTRK1 is associated with favorable clinical features and outcome, whereas expression of NTRK2 and its ligand, brain-derived neurotrophic factor (BDNF), are associated with unfavorable features and outcome. AZ64 (Astra Zeneca) is a potent and selective inhibitor of the NTRK tyrosine kinases that blocks phosphorylation at nanomolar concentrations...
September 2012: Cancer Chemotherapy and Pharmacology
Hans Jørgen Timm Guthe, Torbjørn Nedrebø, Olav Tenstad, Helge Wiig, Ansgar Berg
OBJECTIVES: To measure colloid osmotic pressure in interstitial fluid (COP(i)) from human subcutaneous tissue with the modified wick technique in order to determine influence of topical application of anaesthetics, dry vs. wet wick and implantation time on COP(i). MATERIAL AND METHODS: In 50 healthy volunteers interstitial fluid (IF) was collected by subcutaneous implantation of multi-filamentous nylon wicks. Study subjects were allocated to two groups; one for comparing COP(i) obtained from dry and saline soaked wicks, and one for comparing COP(i) from unanaesthetized skin, and skin after application of a eutectic mixture of local anaesthetic (EMLA®, Astra Zeneca) cream...
2012: PloS One
(no author information available yet)
Current guidelines from the National Institute for Clinical Excellence (NICE) recommend antiplatelet therapy comprising aspirin plus either clopidogrel or prasugrel for patients with acute coronary syndrome (ACS). However, such dual therapy increases the likelihood of bleeding compared to that with aspirin alone. Ticagrelor (Brilique - Astra-Zeneca) is a new oral antiplatelet drug recently licensed in the UK (since publication of the NICE guidelines) for use with aspirin in patients with ACS, including those managed medically or undergoing percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)...
June 2011: Drug and Therapeutics Bulletin
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