Keisuke Kamiya, Naoyuki Hatayama, Mitsuhiro Tawada, Akimasa Asai, Mai Yamauchi, Hiroshi Kinashi, Shunnosuke Kunoki, Makoto Yamaguchi, Masashi Mizuno, Yasuhiro Suzuki, Masataka Banshodani, Takuji Ishimoto, Munekazu Naito, Hideki Kawanishi, Yasuhiko Ito
Peritoneal membrane dysfunction in peritoneal dialysis (PD) is primarily attributed to angiogenesis; however, the integrity of vascular endothelial cells can affect peritoneal permeability. Hyaluronan, a component of the endothelial glycocalyx, is reportedly involved in preventing proteinuria in the normal glomerulus. One hypothesis suggests that development of encapsulating peritoneal sclerosis (EPS) is triggered by protein leakage due to vascular endothelial injury. We therefore investigated the effect of hyaluronan in the glycocalyx on peritoneal permeability and disease conditions...
March 28, 2024: Scientific Reports