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Jacquelyn Gerhart, Colleen Withers, Colby Gerhart, Liliana Werner, Nick Mamalis, Arturo Bravo-Nuevo, Victoria Scheinfeld, Paul FitzGerald, Robert Getts, Mindy George-Weinstein
Myo/Nog cells, named for their expression of MyoD and noggin, enter the eye during early stages of embryonic development. Their release of noggin is critical for normal morphogenesis of the lens and retina. Myo/Nog cells are also present in adult eyes. Single nucleated skeletal muscle cells designated as myofibroblasts arise from Myo/Nog cells in cultures of lens tissue. In this report we document the presence of Myo/Nog cells in the lens, ciliary body and on the zonule of Zinn in mice, rabbits and humans. Myo/Nog cells were rare in all three structures...
March 17, 2018: Experimental Eye Research
Alain Cunqueiro, Meir H Scheinfeld
Intracranial gas is commonly detected on neuroimaging. The recognition of this finding can at first blush be unsettling. Being able to localize this gas to a specific compartment: intraarterial, intravenous, intraparenchymal, subdural, epidural, subarachnoid and intraventricular, is the first step in determining the importance of the gas. Determination of the route of entry: through the skull, extension from a paranasal sinus or the mastoid air cells, via the spine, or trans-vascular, is the other important factor in determining potential consequences...
March 15, 2018: Emergency Radiology
Joanna E Bettmann, David E Scheinfeld, Kort C Prince, Eric L Garland, Katherine V Ovrom
When veterans need effective mental health treatment, many are reluctant to engage in traditional treatment modalities because of stigma. Therapeutic adventure shows promise as a way to engage veterans and enact positive changes in functioning, but little is known about how therapeutic adventure impacts mental health symptoms among veterans. This study examined changes in mental health symptoms and related psychological processes over the course of a 6-day Outward Bound for Veterans (OB4V) program and at a 1-month follow-up...
February 8, 2018: Psychological Services
Fan Li, Liying Ma, Yi Feng, Yuhua Ruan, Jing Hu, Hongshuo Song, Pengtao Liu, Jun Ma, Baolin Rui, Kate Kerpen, Benjamin Scheinfeld, Tuhina Srivastava, David Metzger, Hui Li, Katharine J Bar, Yiming Shao
OBJECTIVES: For both HIV-1 and hepatitis C virus (HCV), assessing the stringency of the transmission process is a scientific priority. Enumerations of transmitted/founder (TF) viruses have shown a strict transmission bottleneck in sexual transmission of HIV-1 and a wide range in the multiplicity of infection in HCV. Here, we aim to determine the stringency of parenteral transmission for HIV-1 and HCV in people who inject drugs (PWID). DESIGN: We used molecular sequencing and several complementary analyses to enumerate the TF HIV-1 and HCV variants in a well described cohort of PWID in Xinjiang, China...
January 28, 2018: AIDS
Meir H Scheinfeld, Daniel A Krieger, Deepa Bhupali, Richard L Zampolin, Amichai J Erdfarb
No abstract text is available yet for this article.
September 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Emily Scheinfeld, Minsun Shim
OBJECTIVE: Emerging adulthood (EA) is an important yet overlooked period for developing long-term health behaviors. During these years, emerging adults adopt health behaviors that persist throughout life. This study applies the Integrative Model of Behavioral Prediction (IMBP) to examine the role of childhood parental communication in predicting engagement in healthful eating during EA. METHODS: Participants included 239 college students, ages 18 to 25, from a large university in the southern United States...
May 1, 2017: American Journal of Health Behavior
Shlomit Goldberg-Stein, David Gutman, Oleg Kaplun, Dan Wang, Abdissa Negassa, Meir H Scheinfeld
No abstract text is available yet for this article.
May 2017: Journal of the American College of Radiology: JACR
Shlomit Goldberg-Stein, William R Walter, E Stephen Amis, Meir H Scheinfeld
PURPOSE: To describe the successful implementation of a structured reporting initiative in a large urban academic radiology department. METHODS: We describe our process, compromises, and top 10 lessons learned in overhauling traditional reporting practices and comprehensively implementing structured reporting at our institution. To achieve our goals, we took deliberate steps toward consensus building, undertook multistep template refinement, and achieved close collaboration with the technical staff, department coders, and hospital information technologists...
July 2017: Current Problems in Diagnostic Radiology
Katharine J Bar, Michael C Sneller, Linda J Harrison, J Shawn Justement, Edgar T Overton, Mary E Petrone, D Brenda Salantes, Catherine A Seamon, Benjamin Scheinfeld, Richard W Kwan, Gerald H Learn, Michael A Proschan, Edward F Kreider, Jana Blazkova, Mark Bardsley, Eric W Refsland, Michael Messer, Katherine E Clarridge, Nancy B Tustin, Patrick J Madden, KaSaundra Oden, Sijy J O'Dell, Bernadette Jarocki, Andrea R Shiakolas, Randall L Tressler, Nicole A Doria-Rose, Robert T Bailer, Julie E Ledgerwood, Edmund V Capparelli, Rebecca M Lynch, Barney S Graham, Susan Moir, Richard A Koup, John R Mascola, James A Hoxie, Anthony S Fauci, Pablo Tebas, Tae-Wook Chun
BACKGROUND: The discovery of potent and broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) has made passive immunization a potential strategy for the prevention and treatment of HIV infection. We sought to determine whether passive administration of VRC01, a bNAb targeting the HIV CD4-binding site, can safely prevent or delay plasma viral rebound after the discontinuation of antiretroviral therapy (ART). METHODS: We conducted two open-label trials (AIDS Clinical Trials Group [ACTG] A5340 and National Institutes of Health [NIH] 15-I-0140) of the safety, side-effect profile, pharmacokinetic properties, and antiviral activity of VRC01 in persons with HIV infection who were undergoing interruption of ART...
November 24, 2016: New England Journal of Medicine
Meir H Scheinfeld, R Joshua Dym, Seymour Sprayregen, Elina Jerschow
No abstract text is available yet for this article.
November 2016: Radiology
Noah Scheinfeld
Combinations of rifampin and clindamycin or rifampin, metronidazole, and moxifloxcin have been reported as effective treatments for hidradenitis suppurativa (HS) Hurley Stage 1 and Hurley Stage 2.  Clinical trials suggest that for stage 1 and mild stage 2 HS, clindamycin 300 mg twice daily and rifampin 300 mg twice daily for 10 weeks can substantially abate HS in ~80% of cases and remit HS in ~50% of cases.  Another study notes use of rifampin-moxifloxacin-metronidazole given for 6 weeks, dosed as rifampin (10 mg/kg once daily), moxifloxacin (400 mg daily), and metronidazole (500 mg thrice daily) with the metronidazole stopped at week 6...
June 15, 2016: Dermatology Online Journal
K Burns, V Chernyak, M H Scheinfeld
AIM: To identify weather and calendar factors that would enable prediction of daily emergency department (ED) imaging volume to aid appropriate scheduling of imaging resources for efficient ED function. MATERIALS AND METHODS: Daily ED triage and imaging volumes for radiography, computed tomography (CT), and ultrasound were obtained from hospital databases for the period between January 2011 and December 2013 at a large tertiary urban hospital with a Level II trauma centre...
December 2016: Clinical Radiology
Meir H Scheinfeld, Amichai J Erdfarb, Daniel A Krieger, Deepa Bhupali, Richard L Zampolin
In 2015, five trials demonstrated the efficacy of endovascular treatment for acute stroke, culminating in the revised American Heart Association/American Stroke Association (AHA/ASA) recommendations for stroke management. The different clinical scales used in these trials may be unfamiliar to emergency and on-call radiologists. The modified Rankin Scale was used to describe patient disability for prestroke assessment in three of the trials and for the 90-day follow up in all five trials. The Barthel index was used in one trial to score prestroke ability to perform activities of daily living...
October 2016: Emergency Radiology
Noah Scheinfeld, Murali Sundaram, Henrique Teixeira, Yihua Gu, Martin Okun
BACKGROUND: Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin disease with frequent comorbidities of painand depression. Adalimumab treatment for 16 weeks improved HS lesions significantly versus placebo (NCT00918255). OBJECTIVE: The relationship between pain and depressive symptoms and the effects of adalimumab on each was examined in this post hoc analysis. METHODS: Patients with moderate to severe HS (N=154) were randomized 1:1:1 to adalimumab 40 mg weekly (ew), adalimumab 40 mg every other week (eow), or placebo...
March 16, 2016: Dermatology Online Journal
Erin E Donovan, Erin C Nelson, Emily Scheinfeld
Although scholarship on coping with cancer implies many ways that coping is communicative, the discursive features of coping have been understudied. The purpose of the present investigation was to theorize the content of cancer blogs, a form of cybercoping, by examining valenced coping-relevant frames that bloggers use to describe their experiences with cancer. This research is both theoretically and methodologically innovative. Theoretically, we advance the concept of cyberframing by connecting the rather disconnected literatures on coping and framing and by studying this topic from a communication perspective...
April 29, 2016: Health Communication
Arturo Bravo-Nuevo, Alice A Brandli, Jacquelyn Gerhart, Jennifer Nichols, Meghan Pitts, Christopher K Sutera, Sarah Assali, Victoria Scheinfeld, George C Prendergast, Jonathan Stone, Mindy George-Weinstein
Myo/Nog cells are essential for eye development in the chick embryo and respond to injury in adult tissues. These cells express mRNA for the skeletal muscle specific transcription factor MyoD, the bone morphogenetic protein (BMP) inhibitor Noggin and the cell surface protein recognized by the G8 monoclonal antibody (mAb). In this study, we determined that Myo/Nog cells are present in low numbers in the retina of the mouse eye. G8-positive Myo/Nog cells were distinguished from neuronal, Müller and microglial cells that were identified with antibodies to calretinin, Chx10, glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1, respectively...
May 2016: Experimental Eye Research
Noah Scheinfeld
No abstract text is available yet for this article.
May 2015: Skinmed
Noah Scheinfeld
No abstract text is available yet for this article.
May 2015: Skinmed
Andrew Friedman, Judah Burns, Meir H Scheinfeld
Our goal was to test the predictive value of high-attenuation material within the maxillary sinus for adjacent facial bone fracture. After IRB approval, all blunt trauma facial CTs performed over a 5-month period at a level II trauma center were reviewed in consensus by three radiologists for the presence of facial fractures or high attenuation maxillary sinus opacity (≥30HU, ≥40HU, or ≥50HU). Three classes of fractures were analyzed: any fracture, any fracture contiguous with the maxillary sinus, and only fractures not contiguous with the maxillary sinus...
December 2015: Emergency Radiology
Allison J Lazard, Emily Scheinfeld, Jay M Bernhardt, Gary B Wilcox, Melissa Suran
A diagnosis of Ebola on US soil triggered widespread panic. In response, the Centers for Disease Control and Prevention held a live Twitter chat to address public concerns. This study applied a textual analytics method to reveal insights from these tweets that can inform communication strategies. User-generated tweets were collected, sorted, and analyzed to reveal major themes. The public was concerned with symptoms and lifespan of the virus, disease transfer and contraction, safe travel, and protection of one's body...
October 1, 2015: American Journal of Infection Control
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