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https://www.readbyqxmd.com/read/28205494/language-deficits-as-a-preclinical-window-into-parkinson-s-disease-evidence-from-asymptomatic-parkin-and-dardarin-mutation-carriers
#1
Adolfo M García, Lucas Sedeño, Natalia Trujillo, Yamile Bocanegra, Diana Gomez, David Pineda, Andrés Villegas, Edinson Muñoz, William Arias, Agustín Ibáñez
OBJECTIVES: The worldwide spread of Parkinson's disease (PD) calls for sensitive and specific measures enabling its early (or, ideally, preclinical) detection. Here, we use language measures revealing deficits in PD to explore whether similar disturbances are present in asymptomatic individuals at risk for the disease. METHODS: We administered executive, semantic, verb-production, and syntactic tasks to sporadic PD patients, genetic PD patients with PARK2 (parkin) or LRRK2 (dardarin) mutation, asymptomatic first-degree relatives of the latter with similar mutations, and socio-demographically matched controls...
February 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28203210/auditory-and-visual-electrophysiology-of-deaf-children-with-cochlear-implants-implications-for-cross-modal-plasticity
#2
David P Corina, Shane Blau, Todd LaMarr, Laurel A Lawyer, Sharon Coffey-Corina
Deaf children who receive a cochlear implant early in life and engage in intensive oral/aural therapy often make great strides in spoken language acquisition. However, despite clinicians' best efforts, there is a great deal of variability in language outcomes. One concern is that cortical regions which normally support auditory processing may become reorganized for visual function, leaving fewer available resources for auditory language acquisition. The conditions under which these changes occur are not well understood, but we may begin investigating this phenomenon by looking for interactions between auditory and visual evoked cortical potentials in deaf children...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28195267/a-puzzling-ovarian-tumour-pregnancy-luteoma-with-diffuse-endometriosis
#3
F Limaiem, S Bouraoui, S Bouslama, A Lahmar, S Mzabi
BACKGROUND: Pregnancy luteoma is a distinctive non-neoplastic hormone dependent lesion arising in pregnancy and mimicking an ovarian tumour. Fewer than 200 cases have been described in the English-language literature. Its clinical and morphological features are characteristic and must be considered in order to prevent diagnostic misinterpretation. To the best of our knowledge the association of pregnancy luteoma with endometriosis has not been reported in literature to date. CASE REPORT: A 30-year-old pregnant woman with no particular past medical history, consulted her gynaecologist at 17 weeks gestation for routine check-up...
September 2016: Pathologica
https://www.readbyqxmd.com/read/28194104/electrophysiological-correlates-of-error-monitoring-and-feedback-processing-in-second-language-learning
#4
Sybrine Bultena, Claudia Danielmeier, Harold Bekkering, Kristin Lemhöfer
Humans monitor their behavior to optimize performance, which presumably relies on stable representations of correct responses. During second language (L2) learning, however, stable representations have yet to be formed while knowledge of the first language (L1) can interfere with learning, which in some cases results in persistent errors. In order to examine how correct L2 representations are stabilized, this study examined performance monitoring in the learning process of second language learners for a feature that conflicts with their first language...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28193245/early-disease-progression-of-hurler-syndrome
#5
Bridget T Kiely, Jennifer L Kohler, Hannah Y Coletti, Michele D Poe, Maria L Escolar
BACKGROUND: Newborn screening for mucopolysaccharidosis type I (MPS I) shows promise to improve outcomes by facilitating early diagnosis and treatment. However, diagnostic tests for MPS I are of limited value in predicting whether a child will develop severe central nervous system disease associated with Hurler syndrome, or minimal or no central nervous system involvement associated with the attenuated phenotypes (Hurler-Scheie and Scheie syndromes). Given that the optimal treatment differs between Hurler syndrome and the attenuated MPS I phenotypes, the absence of a reliable prognostic biomarker complicates clinical decision making for infants diagnosed through newborn screening...
February 14, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28188279/deaf-hard-of-hearing-and-hearing-signing-undergraduates-attitudes-toward-science-in-inquiry-based-biology-laboratory-classes
#6
Cara Gormally
For science learning to be successful, students must develop attitudes toward support future engagement with challenging social issues related to science. This is especially important for increasing participation of students from underrepresented populations. This study investigated how participation in inquiry-based biology laboratory classes affected students' attitudes toward science, focusing on deaf, hard-of-hearing, and hearing signing students in bilingual learning environments (i.e., taught in American Sign Language and English)...
2017: CBE Life Sciences Education
https://www.readbyqxmd.com/read/28185206/what-you-don-t-know-can-hurt-you-the-risk-of-language-deprivation-by-impairing-sign-language-development-in-deaf-children
#7
Wyatte C Hall
A long-standing belief is that sign language interferes with spoken language development in deaf children, despite a chronic lack of evidence supporting this belief. This deserves discussion as poor life outcomes continue to be seen in the deaf population. This commentary synthesizes research outcomes with signing and non-signing children and highlights fully accessible language as a protective factor for healthy development. Brain changes associated with language deprivation may be misrepresented as sign language interfering with spoken language outcomes of cochlear implants...
February 9, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28182997/assessing-language-skills-in-adult-key-word-signers-with-intellectual-disabilities-insights-from-sign-linguistics
#8
REVIEW
Nicola Grove, Bencie Woll
Manual signing is one of the most widely used approaches to support the communication and language skills of children and adults who have intellectual or developmental disabilities, and problems with communication in spoken language. A recent series of papers reporting findings from this population raises critical issues for professionals in the assessment of multimodal language skills of key word signers. Approaches to assessment will differ depending on whether key word signing (KWS) is viewed as discrete from, or related to, natural sign languages...
February 6, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28181684/exercise-based-cardiac-rehabilitation-for-adults-with-atrial-fibrillation
#9
REVIEW
Signe S Risom, Ann-Dorthe Zwisler, Pernille P Johansen, Kirstine L Sibilitz, Jane Lindschou, Christian Gluud, Rod S Taylor, Jesper H Svendsen, Selina K Berg
BACKGROUND: Exercise-based cardiac rehabilitation may benefit adults with atrial fibrillation or those who had been treated for atrial fibrillation. Atrial fibrillation is caused by multiple micro re-entry circuits within the atrial tissue, which result in chaotic rapid activity in the atria. OBJECTIVES: To assess the benefits and harms of exercise-based rehabilitation programmes, alone or with another intervention, compared with no-exercise training controls in adults who currently have AF, or have been treated for AF...
February 9, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28170093/topical-treatments-for-blepharokeratoconjunctivitis-in-children
#10
REVIEW
Michael O'Gallagher, Catey Bunce, Melanie Hingorani, Frank Larkin, Stephen Tuft, Annegret Dahlmann-Noor
BACKGROUND: Blepharokeratoconjunctivitis (BKC) is a type of inflammation of the surface of the eye and eyelids that involves changes of the eyelids, dysfunction of the meibomian glands, and inflammation of the conjunctiva and cornea. Chronic inflammation of the cornea can lead to scarring, vascularisation and opacity. BKC in children can cause significant symptoms including irritation, watering, photophobia and loss of vision from corneal opacity, refractive error or amblyopia.Treatment of BKC is directed towards modification of meibomian gland disease and the bacterial flora of lid margin and conjunctiva, and control of ocular surface inflammation...
February 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28158958/the-responsiveness-and-interpretability-of-the-shoulder-pain-and-disability-index
#11
Marloes Thoomes-de Graaf, Wendy Scholten-Peeters, Edwin Duijn, Yasmaine Karel, Henrica C W de Vet, Bart Koes, Arianne Verhagen
Study Design Clinical measurement study; prospective cohort design. Background Shoulder pain is a common disorder and treatment is most often focused on a reduction of pain and functional disabilities. Several reviews have encouraged the use of the Shoulder Pain and Disability Index (SPADI) to objectify functional disabilities. It is important to assess the responsiveness and interpretability of the SPADI when it is used by patients seeking help by a physical therapist for their shoulder pain in primary care setting...
February 3, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28152954/hepatitis-b-reactivation-in-patients-with-solid-tumors-a-systematic-review-and-meta-analysis
#12
Jordan J Feld, Ronak Saluja, Judy Truong, Adam E Haynes, Kelvin K Chan
: 138 Background: Hepatitis B virus (HBV) affects over 250 million people worldwide. Most people with chronic HBV (HBsAg positive) have no signs or symptoms of infection. However, when exposed to immunosuppression they are at risk of HBV reactivation which can cause hepatitis, liver failure and death. The risk of HBV reactivation in patients receiving chemotherapy for solid tumors, the efficacy of antiviral prophylaxis, and the clinical impact of HBV reactivation in this setting are uncertain...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152342/ambient-intelligence-framework-for-real-time-speech-to-sign-translation
#13
Mwaffaq Otoom, Mohammad A Alzubaidi
Sign language can be used to facilitate communication with and between deaf or hard of hearing (Deaf/HH). With the advent of video streaming applications in smart TVs and mobile devices, it is now possible to use sign language to communicate over worldwide networks. In this article, we develop a prototype assistive device for real-time speech-to-sign translation. The proposed device aims at enabling Deaf/HH people to access and understand materials delivered in mobile streaming videos through the applications of pipelined and parallel processing for real-time translation, and the application of eye-tracking based user-satisfaction detection to support dynamic learning to improve speech-to-signing translation...
February 2, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28144823/abuse-and-misuse-of-pregabalin-and-gabapentin
#14
REVIEW
Kirk E Evoy, Megan D Morrison, Stephen R Saklad
BACKGROUND: Gabapentinoid (pregabalin and gabapentin) abuse is increasingly being reported. OBJECTIVE: To assess the extent of gabapentinoid abuse, characteristics of typical abusers, patterns of abuse, and potential harms in order to bring this trend to providers' attention. METHODS: A systematic review of MEDLINE, Cochrane Library, ClinicalTrials.gov, and US FDA data, indexed through 28 July 2016, utilizing the following searches: pregabalin OR gabapentin OR gabapentinoid AND one of the following: abuse, misuse, overdose, or substance-related disorders[MESH], was conducted...
February 1, 2017: Drugs
https://www.readbyqxmd.com/read/28140670/speech-in-adults-treated-for-unilateral-cleft-lip-and-palate-long-term-follow-up-after-one-or-two-stage-palate-repair
#15
Staffan Morén, Maria Mani, Stålhammar Lilian, Per Åke Lindestad, Mats Holmström
OBJECTIVE:   To evaluate speech in adults treated for unilateral cleft lip and palate with one-stage or two-stage palate closure and compare the speech of the patients with that of a noncleft control group. DESIGN:   Cross-sectional study with long-term follow-up. PARTICIPANTS/SETTING:   All unilateral cleft lip and palate patients born from 1960 to 1987 and treated at Uppsala University Hospital, Sweden, were invited (n = 109). Participation rate was 67% (n = 73) at a mean of 35 years after primary surgery...
January 31, 2017: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/28138351/a-pilot-study-of-deaf-trauma-survivors-experiences-early-traumas-unique-to-being-deaf-in-a-hearing-world
#16
Melissa L Anderson, Kelly S Wolf Craig, Wyatte C Hall, Douglas M Ziedonis
Conducting semi-structured American Sign Language interviews with 17 Deaf trauma survivors, this pilot study explored Deaf individuals' trauma experiences and whether these experiences generally align with trauma in the hearing population. Most commonly reported traumas were physical assault, sudden unexpected deaths, and "other" very stressful events. Although some "other" events overlap with traumas in the general population, many are unique to Deaf people (e.g., corporal punishment at oral/aural school if caught using sign language, utter lack of communication with hearing parents)...
December 2016: Journal of Child & Adolescent Trauma
https://www.readbyqxmd.com/read/28131184/confined-anterior-cerebral-artery-infarction-manifesting-as-isolated-unilateral-axial-weakness
#17
Asaf Honig, Ruth Eliahou, Eitan Auriel
We describe isolated unilateral axial weakness in three patients eventually diagnosed with anterior cerebral artery infarction (ACAI), a new clinical observation. Files of three ACAI patients (2 females, 1 male, ages 55-80) were retrospectively reviewed. All three presented to the ED with sudden unsteadiness. On initial neurological examination, all three patients manifested unilateral truncal deviation to the side contralateral to the weakness, even while seated. There was significant unilateral hypotonia due to substantial paravertebral weakness...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28124383/-there-s-something-in-their-eyes-child-health-services-nurses-experiences-of-identifying-signs-of-postpartum-depression-in-non-swedish-speaking-immigrant-mothers
#18
Malin Skoog, Inger Hallström, Vanja Berggren
BACKGROUND: Due to the current world situation, Sweden has one of the highest asylum applications within the European Union. Immigrant mothers, specifically those who have immigrated during the last ten years and do not speak the language of the new country, are found to be at particular risk of being effected by postpartum depression. AIM: In this study, we elucidate Swedish Child Health Services nurses' experiences of identifying signs of postpartum depression in non-Swedish-speaking immigrant mothers...
January 25, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28123193/5-aminosalicylic-acid-associated-myocarditis-and-pericarditis-a-narrative-review
#19
REVIEW
Glen Brown
BACKGROUND: Use of medications containing the 5-aminosalicylic acid (5-ASA) moiety may cause a rare but potentially lethal side effect involving inflammation of the heart (myocarditis) or pericardium (pericarditis) or both (myopericarditis). Early recognition of 5-ASA as the cause is important to prevent progression of the inflammation. OBJECTIVE: To provide clinicians with information to assist in recognizing the signs and symptoms of 5-ASA-induced cardiac inflammation and the characteristics of the suspected therapy, and in determining the appropriate approach to treatment...
November 2016: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28077059/ignorance-is-not-bliss-the-effect-of-systematic-information-on-immigrants-knowledge-of-and-satisfaction-with-the-danish-healthcare-system
#20
Signe Smith Jervelund, Thomas Maltesen, Camilla Lawaetz Wimmelmann, Jørgen Holm Petersen, Allan Krasnik
AIMS: Suboptimal healthcare utilisation and lower satisfaction with the patient-doctor encounter among immigrants has been documented. Immigrants' lack of familiarity with the healthcare system has been proposed as an explanation for this. This study investigated whether a systematic delivery of information affected immigrants' knowledge of and satisfaction with the Danish healthcare system. METHODS: A prospective, randomised intervention study of 1158 adult immigrants attending two language schools in Copenhagen was conducted...
January 1, 2017: Scandinavian Journal of Public Health
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