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https://www.readbyqxmd.com/read/28915391/hepatitis-b-surface-antigen-incorporated-in-dissolvable-microneedle-array-patch-is-antigenic-and-thermostable
#1
Danielle Poirier, Frédéric Renaud, Vincent Dewar, Laurent Strodiot, Florence Wauters, Jim Janimak, Toshio Shimada, Tatsuya Nomura, Koki Kabata, Koji Kuruma, Takayuki Kusano, Masaki Sakai, Hideo Nagasaki, Takayoshi Oyamada
Alternatives to syringe-based administration are considered for vaccines. Intradermal vaccination with dissolvable microneedle arrays (MNA) appears promising in this respect, as an easy-to-use and painless method. In this work, we have developed an MNA patch (MNAP) made of hydroxyethyl starch (HES) and chondroitin sulphate (CS). In swines, hepatitis B surface antigen (HBsAg) formulated with the saponin QS-21 as adjuvant, both incorporated in HES-based MNAP, demonstrated the same level of immunogenicity as a commercially available aluminum-adjuvanted HBsAg vaccine, after two immunizations 28 days apart...
August 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28888883/host-responses-and-bacterial-colonization-following-inoculation-of-pasteurella-multocida-p52-strain-into-unvaccinated-and-aluminum-hydroxide-gel-hemorrhagic-septicemia-vaccinated-mice
#2
Mamta Singh, Rishendra Verma, Ramane Sangram Pandit, Najeeb Ul Tarfain
Hemorrhagic septicemia is a highly infectious and contagious disease caused by Pasteurella multocida serogroup B:2 in tropical Asian and African countries. The acute inflammatory responses induced by Pasteurella multocida are the main cause of death in hemorrhagic septicemia. Therefore, present study was undertaken to examine the blood cytokine expression profiles (TNF-α, IL-1β, and IL-6), bacterial colonization and histopathological changes of intraperitoneally and subcutaneously challenged vaccinated and unvaccinated mice with 10(2) CFU of P...
September 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28888842/evidence-refuting-the-existence-of-autoimmune-autoinflammatory-syndrome-induced%C3%A2-by-adjuvants-asia
#3
Rohan Ameratunga, David Gillis, Michael Gold, Allan Linneberg, J Mark Elwood
Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) was described in 2011. Over time the condition and its triggers have broadened to include several autoimmune disorders, the macrophagic myofasciitis syndrome, the Gulf war syndrome, the sick building syndrome, siliconosis, and the chronic fatigue syndrome. The aluminum-containing adjuvants in the hepatitis B vaccine and the human papillomavirus vaccine in particular have been stated to be the major causes of the disorder. Here, we review the specificity of the diagnostic criteria for ASIA...
September 6, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28871937/-pleurotus-ferulae-polysaccharide-adjuvant-enhances-the-immune-infertility-of-czp3dna-vaccine
#4
Junyuan Lin, Ying Wang, Jinyu Li, Fuchun Zhang
Objective To investigate the effect of Pleurotus ferulae polysaccharide (PFP) as an adjuvant on the infertility induced by canine zona pellucida 3 (CZP3) DNA vaccine (pcDNA3-CZP3). Methods Female mice were intramuscularly immunized with pcDNA3-CZP3 alone or co-immunized with pcDNA3-CZP3 and aluminum adjuvant or PFP for three times. CZP3-specific antibody titers of antiserum were determined by ELISA. The maturation of dendritic cells (DCs) and the proliferation of T lymphocytes were detected by flow cytometry...
August 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28868897/recurrent-sterile-abscesses-after-immunization-with-aluminum-adjuvant-based-vaccines
#5
Keith M Vargas, Alwyn Koil, Walter Dehority
No abstract text is available yet for this article.
September 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28814229/cell-mediated-and-humoral-immune-responses-to-bordetella-pertussis-inactivated-whole-cells-encapsulated-alginate-microspheres-as-a-new-vaccine-candidate
#6
Naser Mohammadpour Dounighi, Fereshteh Shahcheraghi, Mehdi Razzaghi-Abyaneh, Mojtaba Nofeli, Hossein Zolfagharian
BACKGROUND: Effectiveness of the whole-cell pertussis vaccine is apparent, but improvement in the quality of the vaccine is necessary to achieve strong immunogenicity with a low bacterial number content. METHODS: The inactivated Bordetella pertussis (B. pertussis) cells entrapped microspheres were prepared via an emulsification method and analyzed for morphology, size, size distribution, loading efficiency, loading capacity, release kinetic, in vivo cytokines and antigen specific antibody subclasses...
August 15, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/28790999/immunization-with-recombinant-tcdb-encapsulated-nanocomplex-induces-protection-against-clostridium-difficile-challenge-in-a-mouse-model
#7
Yi-Wen Liu, Yu-Hung Chen, Jenn-Wei Chen, Pei-Jane Tsai, I-Hsiu Huang
Clostridium difficile is considered to be one of the major cause of infectious diarrhea in healthcare systems worldwide. Symptoms of C. difficile infection are caused largely by the production of two cytotoxins: toxin A (TcdA) and toxin B (TcdB). Vaccine development is considered desirable as it would decrease the mounting medical costs and mortality associated with C. difficile infections. Biodegradable nanoparticles composed of poly-γ-glutamic acid (γ-PGA) and chitosan have proven to be a safe and effective antigen delivery system for many viral vaccines...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28780375/adjuvant-formulations-for-virus-like-particle-vlp-based-vaccines
#8
REVIEW
Velasco Cimica, Jose M Galarza
The development of virus-like particle (VLP) technology has had an enormous impact on modern vaccinology. In order to optimize the efficacy and safety of VLP-based vaccines, adjuvants are included in most vaccine formulations. To date, most licensed VLP-based vaccines utilize the classic aluminum adjuvant compositions. Certain challenging pathogens and weak immune responder subjects may require further optimization of the adjuvant formulation to maximize the magnitude and duration of the protective immunity...
August 3, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28777067/schistosoma-mansoni-cercarial-elastase-smce-differences-in-immunogenic-properties-of-native-and-recombinant-forms
#9
Marwa H El-Faham, Katherine J Wheatcroft-Francklow, Helen P Price, Jon R Sayers, Michael J Doenhoff
The Schistosoma mansoni cercarial elastase (SmCE) has previously been shown to be poorly immunogenic in mice. However, a minority of mice were able to produce antibodies against SmCE after multiple immunizations with crude preparations containing the enzyme. These mice were partially protected against challenge infections of S. mansoni. In the present study, we show that in contrast to the poor immunogenicity of the enzymatically active native form of SmCE derived from a crude preparation (cercarial transformation fluid), immunization of CBA/Ca mice with two enzymatically inactive forms, namely purified native SmCE or a recombinant SmCE fused to recombinant Schistosoma japonicum glutathione S-transferase (rSmCE-SjGST), after adsorption onto aluminum hydroxide adjuvant, induced specific anti-SmCE immunoglobulin G (IgG) in all mice within 2 weeks of the second immunization...
September 2017: Parasitology
https://www.readbyqxmd.com/read/28747172/characteristics-of-the-specific-humoral-response-in-patients-with-advanced-solid-tumors-after-active-immunotherapy-with-a-vegf-vaccine-at-different-antigen-doses-and-using-two-distinct-adjuvants
#10
Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Francisco Hernández-Bernal, Katty-Hind Selman-Housein Bernal, Ana de la Torre Santos, Eduardo Rafael Santiesteban Álvarez, Yenima Martín Bauta, Cimara H Bermúdez Badell, Josué de la Torre Pupo, Jorge V Gavilondo, Marta Ayala Avila
BACKGROUND: CIGB-247, a VSSP-adjuvanted VEGF-based vaccine, was evaluated in a phase I clinical trial in patients with advanced solid tumors (CENTAURO). Vaccination with the maximum dose of antigen showed an excellent safety profile, exhibited the highest immunogenicity and was the only one showing a reduction on platelet VEGF bioavailability. However, this antigen dose level did not achieve a complete seroconversion rate in vaccinated patients. These clinical results led us to the question whether a "reserve" of untapped immune response potential against VEGF could exist in cancer patients...
July 26, 2017: BMC Immunology
https://www.readbyqxmd.com/read/28730271/serious-adverse-events-after-hpv-vaccination-a-critical-review-of-randomized-trials-and-post-marketing-case-series
#11
Manuel Martínez-Lavín, Luis Amezcua-Guerra
This article critically reviews HPV vaccine serious adverse events described in pre-licensure randomized trials and in post-marketing case series. HPV vaccine randomized trials were identified in PubMed. Safety data were extracted. Post-marketing case series describing HPV immunization adverse events were reviewed. Most HPV vaccine randomized trials did not use inert placebo in the control group. Two of the largest randomized trials found significantly more severe adverse events in the tested HPV vaccine arm of the study...
July 20, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28725106/development-of-porcine-circovirus-2-pcv2-open-reading-frame-2-dna-vaccine-with-different-adjuvants-and-comparison-with-commercial-pcv2-subunit-vaccine-in-an-experimental-challenge
#12
Changhoon Park, Jiwoon Jeong, Kyuhyung Choi, Su-Jin Park, Ikjae Kang, Chanhee Chae
The objective of this study was to compare the protection against challenge with porcine circovirus 2 (PCV2) induced by an experimental vaccine based on open reading frame (ORF) 2 of PCV2 DNA plus an adjuvant (aluminum hydroxide, cobalt oxide, or liposome) and a commercial PCV2 subunit vaccine. A total of 35 colostrum-fed, cross-bred, conventional piglets were randomly divided into 7 groups. The commercial vaccine was more efficacious against PCV2 challenge than the 4 experimental vaccines according to immunologic, virologic, and pathological outcomes...
July 2017: Canadian Journal of Veterinary Research, Revue Canadienne de Recherche Vétérinaire
https://www.readbyqxmd.com/read/28719287/phase-1-randomized-study-of-a-tetravalent-dengue-purified-inactivated-vaccine-in-healthy-adults-in-the-united-states
#13
RANDOMIZED CONTROLLED TRIAL
Alexander C Schmidt, Leyi Lin, Luis J Martinez, Richard C Ruck, Kenneth H Eckels, Alix Collard, Rafael De La Barrera, Kristopher M Paolino, Jean-François Toussaint, Edith Lepine, Bruce L Innis, Richard G Jarman, Stephen J Thomas
AbstractThe safety and immunogenicity of four formulations of an investigational tetravalent dengue purified inactivated vaccine (DPIV), formulated at 1 or 4 μg with aluminum hydroxide (alum) or at 1 μg with an adjuvant system (AS01E or AS03B), were evaluated in a first-time-in-human, placebo-controlled, randomized, observer-blind, phase 1 trial in the continental United States. Two doses of vaccine or placebo were administered intramuscularly 4 weeks apart to 100 healthy adults 18-39 years of age, randomized 1:1:1:1:1 to receive one of four DPIV formulations or saline placebo...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28712326/calcium-phosphate-nanoparticles-as-a-new-generation-vaccine-adjuvant
#14
Yahua Lin, Xin Wang, Xiaofen Huang, Jun Zhang, Ningshao Xia, Qinjian Zhao
Adjuvants are essential components in vaccine formulations to induce robust immunity against pathogens. The most widely used adjuvants in human vaccines are aluminum salts, that can effectively elicit a T helper type-2 (Th2)-biased humoral immune response for producing a high antibody titer but with a limited cellular immune response. Biocompatible calcium phosphate nanoparticles (CaP-NPs) with tunable characteristics have potentials to function as adjuvants for inducing more balanced T helper type-1 (Th1) and Th2 immune responses...
September 2017: Expert Review of Vaccines
https://www.readbyqxmd.com/read/28710002/diphtheria-toxoid-and-n-trimethyl-chitosan-layer-by-layer-coated-ph-sensitive-microneedles-induce-potent-immune-responses-upon-dermal-vaccination-in-mice
#15
Pim Schipper, Koen van der Maaden, Vincent Groeneveld, Mitchel Ruigrok, Stefan Romeijn, Sven Uleman, Cees Oomens, Gideon Kersten, Wim Jiskoot, Joke Bouwstra
Dermal immunization using antigen-coated microneedle arrays is a promising vaccination strategy. However, reduction of microneedle sharpness and the available surface area for antigen coating is a limiting factor. To overcome these obstacles, a layer-by-layer coating approach can be applied onto pH-sensitive microneedles. Following this approach, pH-sensitive microneedle arrays (positively charged at coating pH5.8 and nearly uncharged at pH7.4) were alternatingly coated with negatively charged diphtheria toxoid (DT) and N-trimethyl chitosan (TMC), a cationic adjuvant...
July 11, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28697661/safety-of-a-proteoliposome-from-neisseria-meningitides-as-adjuvant-for-a-house-dust-mite-allergy-vaccine
#16
Wendy Ramírez, Virgilio Bourg, Damaris Torralba, Elisa Facenda, Beatriz Tamargo, Bárbara O González, Gustavo Sierra, Oliver Pérez, Yordanis Perez-Llano, Alexis Labrada
The proteoliposome (PL) of Neisseria meningitidis serogroup B has been reported as a safe and potent vaccine adjuvant, inducing a TH1-skewed response. The present study describes a pre-clinical safety evaluation of an allergy therapeutic vaccine candidate based on purified allergens from Dermatophagoides siboney house dust mite and PL as adjuvant, both components adsorbed onto aluminum hydroxide gel. Two separate studies of acute toxicity evaluation were performed in mice and rabbits, and two repeat-dose studies were conducted in non-sensitized and allergen-sensitized Balb/c mice, respectively...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28687406/comparative-efficacy-and-toxicity-of-two-vaccine-candidates-against-sporothrix-schenckii-using-either-montanide%C3%A2-pet-gel-a-or-aluminum-hydroxide-adjuvants-in-mice
#17
Deivys Leandro Portuondo, Alexander Batista-Duharte, Lucas Souza Ferreira, Cleverton Roberto de Andrade, Camila Quinello, Damiana Téllez-Martínez, Maria Luiza de Aguiar Loesch, Iracilda Zeppone Carlos
Sporotrichosis is an important zoonosis in Brazil and the most frequent subcutaneous mycosis in Latin America, caused by different Sporothrix species. Currently, there is no effective vaccine available to prevent this disease. In this study, the efficacy and toxicity of the adjuvant Montanide™ Pet Gel A (PGA) formulated with S. schenckii cell wall proteins (ssCWP) was evaluated and compared with that of aluminum hydroxide (AH). Balb/c mice received two subcutaneous doses (1st and 14th days) of either the unadjuvanted or adjuvanted vaccine candidates...
July 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28675247/protection-by-humoral-elements-independent-of-virus-neutralization-activity-against-an-influenza-virus-challenge
#18
Julia Sarkadi, David Kuti, Mate Jankovics, Eva Pallinger, Kinga Fodor, Zoltan Kis, Eva Gonczol, Ildiko Visontai, Istvan Jankovics
To investigate the protective efficacy of a seasonal trivalent inactivated whole virion influenza vaccine (TIV) adjuvanted with aluminum phosphate (Fluval AB, referred to here as TIV+Al), we immunized mice with the TIV+Al, and as controls, with TIV, TIV+Al combined with Freund adjuvant (TIV+Al+F), inactivated A/PR/8/34(H1N1) (PR8) strain or PBS, and challenged them with a lethal dose of a mouse-adapted PR8 virus. Serum pools from immunized mice were passively transferred to recipient mice that were then challenged similarly...
July 4, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28668573/safety-and-immunogenicity-of-an-inactivated-cell-culture-derived-h7n9-influenza-vaccine-in-healthy-adults-a-phase-i-ii-prospective-randomized-open-label-trial
#19
Un-In Wu, Szu-Min Hsieh, Wen-Sen Lee, Ning-Chi Wang, Hsiang-Chi Kung, Tsong-Yih Ou, Fu-Lun Chen, Te-Yu Lin, Yee-Chun Chen, Shan-Chwen Chang
BACKGROUND: We conducted a phase I/II clinical trial to evaluate the safety and immunogenicity of a Madin-Darby canine kidney (MDCK) cell-grown inactivated H7N9 influenza vaccine for pandemic preparedness purposes. METHODS: Between April 7, 2015 and May 27, 2016, healthy adults aged 20-60years were enrolled sequentially in phase I (n=40) and phase II (n=160) from three hospitals in Taiwan and randomized to receive 2 doses of whole-virus H7N9 vaccine (15 or 30μg hemagglutinin antigen (HA) with or without an aluminum hydroxide adjuvant) at 21-day intervals...
June 28, 2017: Vaccine
https://www.readbyqxmd.com/read/28645718/optimizing-adjuvants-for-intradermal-delivery-of-menc-glycoconjugate-vaccine
#20
Agnese Donadei, Cristiana Balocchi, Maria R Romano, Luigi Panza, Roberto Adamo, Francesco Berti, Derek T O'Hagan, Simona Gallorini, Barbara C Baudner
Intradermal vaccine delivery is a promising alternative to the conventional intramuscular route. The skin layer is immunologically supported by a densely network of antigen presenting cells, while the skeletal muscle is loaded with a relatively sparse population of APCs. Nevertheless, the vaccine to be suitable for intradermal delivery needs a new formulation to facilitate either smaller injection volumes or the introduction into new delivery devises as micro-needles. This study presents a proof of concept for intradermal delivery of the MenC-CRM197 glycoconjugate vaccine using a mouse model...
July 13, 2017: Vaccine
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