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Nozomi Matsuda, Atsuko Taki, Atsumi Tsuji, Keisuke Nakajima, Kei Takasawa, Chikako Morioka, Yoshihiro Minosaki, Kikuko Oku, Kenichi Kashimada, Tomohiro Morio
Factors affecting growth and development in extremely low birth weight infants (ELBWIs) born small for gestational age (SGA) have not been precisely elucidated. We performed a retrospective analysis of ELBWIs born SGA who were treated in the neonatal intensive care unit of Kawaguchi Municipal Medical Centre, Japan. A total 244 ELBWIs were born from 2003 to 2010, and 31 were born with weight and height below the 10th percentile for their gestational age. Among the 31 ELBWIs born SGA, we excluded 9 who died before they reached 3 yr of age or who had severe developmental retardation...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
Kensuke Ohashi, Tsugumichi Koshinaga, Shuichiro Uehara, Takeshi Furuya, Hide Kaneda, Hiroyuki Kawashima, Taro Ikeda
OBJECTIVE: In recent years, improved survival rates of extremely low birth weight infants (ELBWIs) have led to an increasing number of enterostomy performed for those with meconium obstruction of prematurity (MOP)1,2 , spontaneous intestinal perforation (SIP)3,4 . To prevent serious stoma-related complications such as stoma side perforation, prolapse, fall and surgical site infection, we introduce our new "sutureless enterostomy" technique. METHODS: We present the procedures in detail...
November 2017: Journal of Pediatric Surgery
Sung Hoon Chung, Chong Woo Bae
The survival rate (SR) of very low birth weight infants (VLBWIs) and extremely low birth weight infants (ELBWIs) is a health indicator of neonatal intensive care unit (NICU) outcomes. The Korean Neonatal Network (KNN) was established in 2013, and a system has been launched to manage the registration and quality improvement of VLBWIs. The SR of the VLBWIs significantly increased to 85.7% in the 2010s compared with 83.0% in the 2000s. There was also a significant increase in the SR of the ELBWIs from 66.1% to 70...
August 2017: Journal of Korean Medical Science
Mayumi Matsufuji, Nozomi Sano, Hisashi Tsuru, Sachio Takashima
OBJECTIVE: To determine the morphological characteristics and pathogenic factors of cerebellar injury in extremely low birth weight infants (ELBWI). SUBJECTS AND METHODS: Neuroimaging examination was performed on 17 eligible surviving ELBWI. Their MR images were assessed and classified its pattern of cerebellar injuries. Brain pathology was examined on 15 patients, who isolated this neuroimaging subjects. The trend of brain pathologies was revealed. RESULTS: Four types of morphological pattern were recognized: (i) the absence of major portions in the cerebellum (6/17 cases); (ii) focal cerebellar tissue loss (2/17); (iii) unilateral cerebellar atrophy/hypoplasia (3/17); (iv) small cerebellum with entrapped fourth ventricle (6/17)...
May 17, 2017: Brain & Development
Hidehiko Maruyama, Shoichiro Amari, Hideshi Fujinaga, Shuhei Fujino, Junko Nagasawa, Yuka Wada, Keiko Tsukamoto, Yushi Ito
INTRODUCTION: Bone fracture is a complication of extremely low birth weight infants (ELBWIs). This study aimed to analyze risk factors for bone fracture in a population of severe small-for-gestational-age (SGA) ELBWIs. METHODS: We retrospectively studied data from ELBWIs with a birth weight <1000g and <-2 standard deviations (SDs) born at the National Center for Child Health and Development, Japan, from 2013 to 2015. Infants were divided into fracture and control groups...
March 2017: Early Human Development
M Miyata, K Toyoshima, H Yoda, M Murase, H Kawato, K Yamamoto, K Tanaka, M Kotani, M Kobayashi
National surveys were conducted in Japan to assess the current practices for circulatory management of extremely-low-birth-weight infants (ELBWIs) in acute phases. Approximately 80 and 100 institutions were surveyed in 2006 and 2011, respectively. Echocardiography was identified as an important diagnostic tool at 95% of the surveyed institutions. Furthermore, 74% of the institutions survey in 2011 used vasodilator agents. In 2011, the mean velocity of circumferential fiber shortening (mVcfc) and left ventricular end-systolic wall stress (ESWS) were used by 60% of the surveyed institutions to evaluate the relationship between afterload of the left ventricle and left ventricular contractility...
September 16, 2016: Journal of Neonatal-perinatal Medicine
Satoko Ito, Tadashi Matsuda, Haruo Usuda, Shimpei Watanabe, Ryuta Kitanishi, Takushi Hanita, Tatsuya Watanabe, Osamu Adachi
Surgical ligation for patent ductus arteriosus (PDA) in extremely low birth weight infants (ELBWIs) has been shown a possible association with neurodevelopmental impairment (NDI) because of its invasiveness. However, we have undergone surgical ligation for ELBWIs immediately after cyclooxygenase inhibitor failed to close a hemodynamically significant PDA (hsPDA) to maintain proper systemic circulation. We aimed to determine the effect of surgical ligation for hsPDA on NDI in ELBWIs. In enrolled 71 ELBWIs, the clinical parameters, including the developmental quotient (DQ), were collected and compared among three groups that were divided by closure mode: spontaneous closure (n = 11), cyclooxygenase inhibitor therapy (n = 37) and surgical ligation (n = 23)...
September 2016: Tohoku Journal of Experimental Medicine
Motofumi Torikai, Satoshi Ibara, Satoshi Ieiri, Takashi Hamada, Hiroyuki Noguchi, Kazunobu Sueyoshi, Takeo Fukuda, Kazuhiro Abeyama
PURPOSE: Intestinal perforation (IP) is a fatal complication in extremely low birth weight infants (ELBWI). We started administrating enteral miconazole (MCZ) to ELBWI in 2002. Since then, the incidence of IP has significantly decreased. The aim of this study was to elucidate the prophylactic effect of MCZ for the treatment of neonatal IP, and to establish a new prophylactic concept for this disease. METHODS: In in vivo experiments, the effects of MCZ were examined histopathologically using a mouse model of intestinal ischemia...
October 2016: Pediatric Surgery International
Masaya Yamoto, Yusuke Nakazawa, Koji Fukumoto, Hiromu Miyake, Hideaki Nakajima, Akinori Sekioka, Akiyoshi Nomura, Kei Ooyama, Yutaka Yamada, Katsushi Nogami, Yuko Van, Chisako Furuta, Reiji Nakano, Yasuhiko Tanaka, Naoto Urushihara
PURPOSE: Surgical intestinal disorders (SID), such as necrotizing enterocolitis (NEC), focal intestinal perforation (FIP), and meconium-related ileus (MRI), are serious morbidities in extremely low birth weight (ELBW, birth weight <1000 g) infants. From 2010, we performed enteral antifungal prophylaxis (EAP) in ELBWI to prevent for SID. The aim of this study was to identify disease-specific risk factors and to evaluate the efficacy of prevention for SID in ELBW infants. METHODS: A retrospective chart review of all consecutive patients between January 2006 and March 2015, which included 323 ELBW infants who were admitted to Shizuoka Children's Hospital, was conducted...
September 2016: Pediatric Surgery International
S K Bharwani, B F Green, J C Pezzullo, S S Bharwani, S S Bharwani, R Dhanireddy
OBJECTIVE: Two recent meta-analyses have studied the association of exclusive or mainly human milk intake (HMI) on retinopathy of prematurity (ROP). One of these meta-analysis found a protective effect of only or mainly HMI on Severe ROP but not on any stage ROP. However, both these meta-analyses did not find protection from any stage ROP or Severe ROP with any amount of HMI. The objective of this study was to study the association between any amount of HMI and the development of All ROP and Severe ROP in very-low birth weight infants (VLBWI) and extremely low birth weight infants (ELBWI) by systematic review using PRISMA-P guidelines and meta-analysis...
November 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Kenichi Maruyama
BACKGROUND: Extremely low-birthweight infants (ELBWI) are at greater risk of developing hepatoblastoma than are normal-weight infants. Serum α-fetoprotein (AFP) plays an important role as a tumor marker in the diagnosis of hepatoblastoma, therefore the aim of this study was to determine the changes in serum AFP concentration after birth in ELBWI. METHODS: Data were obtained for infants born between January 2005 and March 2008 with birthweight <1000 g who were followed up at Gunma Children's Medical Center with clinical examinations, including monitoring of the development of hepatoblastoma...
February 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
Tomohiko Nakamura, Naohiro Yonemoto, Masahiro Nakayama, Shinya Hirano, Hirofumi Aotani, Satoshi Kusuda, Masanori Fujimura, Masanori Tamura
OBJECTIVE: We hypothesised that a prophylactic inhaled steroid would prevent the progression of bronchopulmonary dysplasia (BPD) in extremely low birthweight infants (ELBWIs). DESIGN: This study was a multicentre, randomised, double-blinded, placebo-controlled trial. SETTING: This investigation was conducted in 12 level III neonatal intensive care units (NICUs). PATIENTS: A total of 211 ELBWIs requiring ventilator support were enrolled...
April 8, 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
Veronica Mardegan, Irene Satariano, Nicoletta Doglioni, Giulio Criscoli, Francesco Cavallin, Camilla Gizzi, Claudio Martano, Fabrizio Ciralli, Flaminia Torielli, Paolo Ernesto Villani, Sandra Di Fabio, Lorenzo Quartulli, Luigi Giannini, Daniele Trevisanuto
OBJECTIVE: International Guidelines provide a standardised approach to newborn resuscitation in the DR and, in their most recent versions, recommendations dedicated to management of ELBWI were progressively increased. It is expected that introduction in clinical practice and dissemination of the most recent evidence should be more consistent in academic than in non-academic hospitals. The aim of the study was to compare adherence to the International Guidelines and consistency of practice in delivery room management of extremely low birth weight infants between academic and non-academic institutions...
2016: Journal of Maternal-fetal & Neonatal Medicine
Francesca Rech Morassutti, Francesco Cavallin, Patrizia Zaramella, Renata Bortolus, Matteo Parotto, Daniele Trevisanuto
OBJECTIVE: To explore the possible association between rewarming rate and neonatal outcomes in extremely low birth weight infants (ELBWIs) with hypothermia. STUDY DESIGN: All ELBWIs with hypothermia (temperature < 36.0°C) on neonatal intensive care unit (NICU) admission were retrospectively evaluated. Rewarming rate was analyzed as both a dichotomous (≥ 0.5°C/h rapid group; < 0.5°C/h slow group) and a continuous variable. Multivariable analysis was performed to explore the relation between rewarming rate and several outcomes, adjusting for clinically relevant confounders...
September 2015: Journal of Pediatrics
(no author information available yet)
OBJECTIVE: Extremely preterm (EP) and extremely low birth weight infants (ELBWI) tended to suffer from some serious complications. How to treat and make them survive reflect the progress of perinatal medicine and neonatal treatment technology. But in our country, there was still lack of data analysis about the morbidities and interventions of large sample survey on such infants. This study was designed to survey the in-hospital morbidities of EP and ELBWI who had been admitted to neonatology departments...
May 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Hye Soo Yoo, Se In Sung, Yu Jin Jung, Myung Sook Lee, Young Mi Han, So Yoon Ahn, Yun Sil Chang, Won Soon Park
PURPOSE: Extremely low birth weight infants (ELBWIs) have a high risk of acquiring cytomegalovirus (CMV) infection via breast milk and consequently developing serious symptoms. We evaluated whether freeze-thawing or pasteurization could prevent postnatal CMV infection transmitted through breast milk in ELBWIs. MATERIALS AND METHODS: Medical records of 385 ELBWIs with whole milk feeding, and freeze-thawed or pasteurized breast milk feeding were reviewed retrospectively...
July 2015: Yonsei Medical Journal
Katsuhisa Hirano, Akio Kubota, Masahiro Nakayama, Hisayoshi Kawahara, Akihiro Yoneda, Yuko Tazuke, Gakuto Tani, Tomohiro Ishii, Taro Goda, Satoshi Umeda, Shinya Hirno, Jun Shiraishi, Hirnoyuki Kitajima
BACKGROUND: The aim of this study was to investigate factors associated with the development of parenteral nutrition-associated liver disease (PNALD) and to examine the clinicopathological relationship of PNALD in extremely low-birthweight infants (ELBWI). METHODS: The subjects were 13 ELBWI who had received PN because of intestinal perforation or functional ileus between 2000 and 2013. We measured the serum levels of biochemical parameters, including aspartate aminotransferase, alanine aminotransferase, and direct bilirubin...
August 2015: Pediatrics International: Official Journal of the Japan Pediatric Society
Yan Zhuang, Xirong Gao, Xinhui Liu, Yuee Xiong, Yu Liu, Qiong Zhang
OBJECTIVE: To analyze the clinical features and prognosis of extremely low birth weight infants (ELBWI). METHOD: Data of totally 165 hospitalized ELBWI between August 1st, 2008 and November 30th, 2013 in Hunan Children's Hospital were analyzed. The information of general data and births, prenatal care, delivery room stabilization, transfer information, complications, treatment, outcome and follow up were summarized. RESULT: (1) One hundred and sixty-five ELBWI were involved, their mean gestational age was (28...
October 2014: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
(no author information available yet)
OBJECTIVE: With the progress of perinatal medicine and neonatal treatment technology, more and more extremely preterm (EP) and extremely low birth weight infant (ELBWI) survived all over the world. But in our country, there is still lack of survival analysis of large sample survey in this field. This study was designed to survey the survival and mortality rate of EP and ELBWI who were admitted to neonatology departments. METHOD: Clinical data of EP and ELBWI, who were discharged from January 1, 2008 to December 31, 2012, were collected retrospectively from twenty tertiary neonatology departments in Guangdong province...
October 2014: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Lian Wang, Juan Li, Jian Mao, Jing Zhang, Dan Chen
OBJECTIVE: To analyze the clinical data of very low birth weight infants (VLBWIs) and extremely low birth weight infants (ELBWIs) (birth weight ≤1 200 g) and to provide prewarning indicators for prognostic evaluation and clinical intervention. METHODS: A retrospective analysis was performed on the clinical data of 108 VLBWIs and ELBWIs to investigate the maternal history of diseases during pregnancy, neonatal birth status, the process of diagnosis and treatment, and prognosis...
June 2014: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
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