Koshiro Sugita, Mitsuru Muto, Masakazu Murakami, Keisuke Yano, Toshio Harumatsu, Shun Onishi, Koji Yamada, Waka Yamada, Makoto Matsukubo, Takafumi Kawano, Seiro Machigashira, Motofumi Torikai, Chie Ishihara, Takuya Tokuhisa, Satoshi Ibara, Satoshi Ieiri
PURPOSE: Our previous clinical pilot study reported that miconazole (MCZ) prevented morbidity from surgical necrotizing enterocolitis (NEC). The present study re-investigated this effect in a long-term cohort over 20 years. METHODS: We conducted a retrospective cohort study from April 1998 to March 2020. A total of 1169 extremely low-birth-weight infants (ELBWIs) admitted to our neonatal intensive care unit, including 45 with NEC (3.8%), underwent surgery. Since 2002, protocol MCZ administration for 3 weeks has been applied for neonates born before 26 weeks' gestation or weighing under 1000 g...
February 4, 2023: Pediatric Surgery International