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https://www.readbyqxmd.com/read/27926940/inflammasome-independent-nlrp3-restriction-of-a-protective-early-neutrophil-response-to-pulmonary-tularemia
#1
Sivakumar Periasamy, Hongnga T Le, Ellen B Duffy, Heather Chin, Jonathan A Harton
Francisella tularensis (Ft) causes a frequently fatal, acute necrotic pneumonia in humans and animals. Following lethal Ft infection in mice, infiltration of the lungs by predominantly immature myeloid cells and subsequent myeloid cell death drive pathogenesis and host mortality. However, following sub-lethal Ft challenge, more mature myeloid cells are elicited and are protective. In addition, inflammasome-dependent IL-1β and IL-18 are important for protection. As Nlrp3 appears dispensable for resistance to infection with Francisella novicida, we considered its role during infection with the virulent Type A strain SchuS4 and the attenuated Type B live vaccine strain LVS...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27926928/an-interactome-centered-protein-discovery-approach-reveals-novel-components-involved-in-mitosome-function-and-homeostasis-in-giardia-lamblia
#2
Samuel Rout, Jon Paulin Zumthor, Elisabeth M Schraner, Carmen Faso, Adrian B Hehl
Protozoan parasites of the genus Giardia are highly prevalent globally, and infect a wide range of vertebrate hosts including humans, with proliferation and pathology restricted to the small intestine. This narrow ecological specialization entailed extensive structural and functional adaptations during host-parasite co-evolution. An example is the streamlined mitosomal proteome with iron-sulphur protein maturation as the only biochemical pathway clearly associated with this organelle. Here, we applied techniques in microscopy and protein biochemistry to investigate the mitosomal membrane proteome in association to mitosome homeostasis...
December 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27926908/community-perceptions-of-biobanking-participation-a-qualitative-study-among-mexican-americans-in-three-texas-cities
#3
Natalia I Heredia, Sarah Krasny, Larkin L Strong, Laura Von Hatten, Lynne Nguyen, Belinda M Reininger, Lorna H McNeill, María E Fernández
BACKGROUND: Most biospecimens in the US are collected from non-Hispanic Whites, limiting the generalizability of findings. There is a need to increase participation in biobanking among ethnic and racial minorities. The purpose of this study was to use qualitative methods to identify factors that may influence Mexican-American individuals' willingness to participate in biobanking. METHODS: We conducted 15 focus groups in three Texas cities with Mexican-American individuals, in both Spanish and English...
December 8, 2016: Public Health Genomics
https://www.readbyqxmd.com/read/27926852/polar-localization-of-the-serine-chemoreceptor-of-escherichia-coli-is-nucleoid-exclusion-dependent
#4
Ramakanth Neeli-Venkata, Sofia Startceva, Teppo Annila, Andre S Ribeiro
We studied whether nucleoid exclusion contributes to the segregation and retention of Tsr chemoreceptor clusters at the cell poles. Using live time-lapse, single-cell microscopy measurements, we show that the single-cell spatial distributions of Tsr clusters have heterogeneities and asymmetries that are consistent with nucleoid exclusion and cannot be explained by the diffusion-and-capture mechanism supported by Tol-Pal complexes at the poles. Also, in cells subjected to ampicillin, which enhances relative nucleoid lengths, Tsr clusters locate relatively closer to the cell extremities, whereas in anucleated cells (deletion mutants for mukB), the Tsr clusters are closer to midcell...
December 6, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27926828/harnessing-cancer-cell-metabolism-for-theranostic-applications-using-metabolic-glycoengineering-of-sialic-acid-in-breast-cancer-as-a-pioneering-example
#5
REVIEW
Haitham A Badr, Dina M M AlSadek, Motawa E El-Houseini, Christopher T Saeui, Mohit P Mathew, Kevin J Yarema, Hafiz Ahmed
Abnormal cell surface display of sialic acids - a family of unusual 9-carbon sugars - is widely recognized as distinguishing feature of many types of cancer. Sialoglycans, however, typically cannot be identified with sufficiently high reproducibility and sensitivity to serve as clinically accepted biomarkers and similarly, almost all efforts to exploit cancer-specific differences in sialylation signatures for therapy remain in early stage development. In this report we provide an overview of important facets of glycosylation that contribute to cancer in general with a focus on breast cancer as an example of malignant disease characterized by aberrant sialylation...
November 25, 2016: Biomaterials
https://www.readbyqxmd.com/read/27926826/potential-of-a-bpv1-l1-vlp-vaccine-to-prevent-bpv1-or-bpv2-induced-pseudo-sarcoid-formation-and-safety-and-immunogenicity-of-ecpv2-l1-vlps-in-the-horse
#6
Edmund K Hainisch, Hans Abel-Reichwald, Saeed Shafti-Keramat, Barbara Pratscher, Annunziata Corteggio, Giuseppe Borzacchiello, Maria Wetzig, Christoph Jindra, Alexander Tichy, Reinhard Kirnbauer, Sabine Brandt
We have previously shown that immunization of horses with BPV1 L1 virus-like particles (VLP) is safe and highly immunogenic, and that bovine papillomavirus types 1 and 2 (BPV1, BPV2) are closely related serotypes. Here we evaluated the protective potential of a BPV1 L1 VLP vaccine against experimental BPV1 and BPV2 challenge, and studied the safety and immunogenicity of a bivalent EcPV2/BPV1 L1 VLP vaccine. Fourteen healthy horses were immunized with BPV1 L1 VLPs (100 µg/injection) plus adjuvant on days 0 and 28, whilst seven remained unvaccinated...
December 7, 2016: Journal of General Virology
https://www.readbyqxmd.com/read/27926807/evaluation-of-a-national-e-mentoring-program-for-ethnically-diverse-student-nurse-midwives-and-student-midwives
#7
Maria Valentin-Welch
INTRODUCTION: The US racial profile is changing rapidly, yet the nursing and midwifery professions are not evolving accordingly. The lack of racial and ethnic diversity within these health professions negatively affects efforts to eliminate persistent health disparities. To address this issue, the Midwives of Color Committee (MOCC) of the American College of Nurse-Midwives (ACNM) created a national online mentoring program in 2011 to support midwifery students of color. An evaluation of the program is reported here...
November 2016: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/27926787/comparison-of-the-effects-of-a-balanced-crystalloid-based-and-a-saline-based-tetrastarch-solution-on-canine-whole-blood-coagulation-and-platelet-function
#8
Annina Reuteler, Shannon Axiak-Flammer, Judith Howard, Katja-Nicole Adamik
OBJECTIVE: To evaluate the effects of a 6% hydroxyethyl starch (130/0.42) solution in either a buffered, electrolyte-balanced (HES-BAL), or a saline (HES-SAL) carrier solution on canine platelet function and whole blood coagulation. DESIGN: Prospective, randomized study. SETTING: University teaching hospital. ANIMALS: Thirty-seven client-owned dogs undergoing general anesthesia for arthroscopy or imaging studies. INTERVENTIONS: Dogs received a 15 mL/kg intravenous bolus of HES-SAL (n = 13), HES-BAL (n = 14), or a modified Ringer's solution (n = 10) over 30-40 minutes...
December 7, 2016: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/27926743/antecedents-of-new-onset-major-depressive-disorder-in-children-and-adolescents-at-high-familial-risk
#9
Frances Rice, Ruth Sellers, Gemma Hammerton, Olga Eyre, Rhys Bevan-Jones, Ajay K Thapar, Stephan Collishaw, Gordon T Harold, Anita Thapar
Importance: Early-onset major depressive disorder (MDD) is common in individuals at high familial risk of depression and is associated with poor long-term mental health, social, and educational outcomes. Objectives: To examine the developmental pathways that lead to first-episode adolescent-onset MDD (incident cases) in those at high familial risk and to postulate a theoretically informed model that enables simultaneous testing of different pathways to incident adolescent-onset MDD composed of contributions from familial/genetic and social risk factors, as well as effects via specific clinical antecedents...
December 7, 2016: JAMA Psychiatry
https://www.readbyqxmd.com/read/27926681/influence-of-immediate-and-delayed-lower-limb-amputation-compared-with-lower-limb-salvage-on-functional-and-mental-health-outcomes-post-rehabilitation-in-the-u-k-military
#10
Peter Ladlow, Rhodri Phillip, Russell Coppack, John Etherington, James Bilzon, M Polly McGuigan, Alexander N Bennett
BACKGROUND: Medical practitioners face difficult decisions over whether to amputate or to salvage a lower limb that has undergone trauma. To our knowledge, there has been little evidence reporting the impact of different surgical decisions on functional and mental health outcomes following intensive rehabilitation that might inform decision-making. METHODS: This study is a retrospective, independent-group comparison of rehabilitation outcomes from a U.K. military complex trauma rehabilitation center...
December 7, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27926668/brief-report-interpersonal-and-intrapersonal-factors-as-parallel-independent-mediators-in-the-association-between-internalized-hiv-stigma-and-art-adherence
#11
Victoria C Seghatol-Eslami, Heather E Dark, James L Raper, Michael J Mugavero, Janet M Turan, Bulent Turan
INTRODUCTION: People living with HIV (PLWH) need to adhere to antiretroviral therapy (ART) to achieve optimal health. One reason for ART nonadherence is HIV-related stigma. OBJECTIVES: We aimed to examine whether HIV treatment self-efficacy (an intrapersonal mechanism) mediates the stigma-adherence association. We also examined whether self-efficacy and the concern about being seen while taking HIV medication (an interpersonal mechanism) are parallel mediators independent of each other...
January 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27926651/factors-underlying-the-temporal-increase-in-maternal-mortality-in-the-united-states
#12
K S Joseph, Sarka Lisonkova, Giulia M Muraca, Neda Razaz, Yasser Sabr, Azar Mehrabadi, Enrique F Schisterman
OBJECTIVE: To identify the factors underlying the recent increase in maternal mortality ratios (maternal deaths per 100,000 live births) in the United States. METHODS: We carried out a retrospective study with data on maternal deaths and live births in the United States from 1993 to 2014 obtained from the birth and death files of the Centers for Disease Control and Prevention. Underlying causes of death were examined between 1999 and 2014 using International Classification of Diseases, 10th Revision (ICD-10) codes...
December 2, 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27926598/acculturation-and-postpartum-depressive-symptoms-among-hispanic-women-in-the-united-states-systematic-review
#13
Dalia Alhasanat, Carmen Giurgescu
PURPOSE: The purpose of this review was to evaluate studies that examined the relationship between acculturation and postpartum depression (PPD) among immigrant and/or refugee women in the United States. METHODS: A systematic, computer-assisted search of quantitative, English-language, peer-reviewed, published research articles was conducted in the Scopus, PsycINFO, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Maternity and Infant Care databases using the keyword terms of "postpartum depression" and "perinatal depression" in combination with "acculturation...
January 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/27926595/impact-of-skeletal-muscle-mass-index-intramuscular-adipose-tissue-content-and-visceral-to-subcutaneous-adipose-tissue-area-ratio-on-early-mortality-of-living-donor-liver-transplantation
#14
Yuhei Hamaguchi, Toshimi Kaido, Shinya Okumura, Atsushi Kobayashi, Hisaya Shirai, Shintaro Yagi, Naoko Kamo, Hideaki Okajima, Shinji Uemoto
BACKGROUND: Skeletal muscle depletion has been shown to be an independent risk factor for poor survival in various diseases. However, in surgery, the significance of other body components including visceral and subcutaneous adipose tissue remains unclear. METHODS: This retrospective study included 250 adult patients undergoing living donor liver transplantation (LDLT) between January 2008 and April 2015. Using preoperative plain CT imaging at the third lumbar vertebra level, skeletal muscle mass, muscle quality, and visceral adiposity were evaluated by the skeletal muscle mass index (SMI), intramuscular adipose tissue content (IMAC), and visceral to subcutaneous adipose tissue area ratio (VSR), respectively...
December 6, 2016: Transplantation
https://www.readbyqxmd.com/read/27926554/intraoperative-archive-of-right-colonic-vascular-variability-aids-central-vascular-ligation-and-redefines-gastrocolic-trunk-of-henle-variants
#15
Jamal F Alsabilah, Syed A Razvi, Mahdi H Albandar, Nam K Kim
BACKGROUND: Vascular supply to the right colon has become an issue because of high variability and subsequent impact on minimally invasive surgery. Past cadaveric or radiologic anatomic assessments are noncomprehensive. OBJECTIVE: Intraoperative charting of right colonic arteriovenous anatomy was undertaken to determine the incidence and scope of vascular variations. DESIGN: Vascular anatomy variations were documented in snapshot images, captured during laparoscopic video recordings or through open surgical digital photography...
January 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/27926501/abdominal-radical-trachelectomy-guided-by-sentinel-lymph-node-biopsy-for-stage-ib1-cervical-cancer-with-tumors-2-cm
#16
Xiangyun Deng, Ying Zhang, Dapeng Li, Xiaoling Zhang, Hui Guo, Fei Wang, Xiugui Sheng
Accuracy of prediction of pelvic lymph node status using sentinel lymph node biopsy (SLNB), and outcomes of SLNB-guided abdominal radical trachelectomy (ART) were assessed. Patients with stage IB1 (Figure 2009) cervical cancer and with tumors >2 cm were enrolled. Prior to fertility-sparing surgery 99mTc-labeled phytate was administered. SLNs were intraoperatively identified, excised, and assessed using fast-frozen sections. Systematic bilateral pelvic lymphadenectomy with or without para-aortic lymphadenectomy was subsequently undertaken...
December 3, 2016: Oncotarget
https://www.readbyqxmd.com/read/27926488/blocking-ezh2-methylation-transferase-activity-by-gsk126-decreases-stem-cell-like-myeloma-cells
#17
Delong Zeng, Maoxing Liu, Jingxuan Pan
EZH2 is a critical epigenetic regulator that is deregulated in various types of cancers including multiple myeloma (MM). In the present study, we hypothesized that targeting EZH2 might induce apoptosis in myeloma cells including stem cell-like cells (CSCs). We investigated the effect of EZH2 inhibition on MM cells using a potent inhibitor (GSK126). The results showed that GSK126 effectively abrogated the methylated histone 3 (H3K27me3) level in MM.1S and LP1 cells, and inhibited the number of live cells and colony formation in soft agar of six MM cell lines...
December 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27926450/changing-health-behavior-motivation-from-i-must-to-i-want
#18
S Knecht, P Kenning
In the past, medicine was dominated by acute diseases. Since treatments were unknown to patients they followed their medical doctors´ directives-at least for the duration of the disease. Behavior was thus largely motivated by avoiding expected costs associated with alternative behaviors (I-must). The health challenges prevailing today are chronic conditions resulting from the way we chose to live. Traditional directive communication has not been successful in eliciting and maintaining appropriate lifestyle changes...
2016: Progress in Brain Research
https://www.readbyqxmd.com/read/27926386/we-dream-in-data-but-we-live-in-letters-the-jvir-letters-issue
#19
EDITORIAL
Ziv J Haskal
No abstract text is available yet for this article.
November 2016: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/27926353/roles-of-body-image-related-experiential-avoidance-and-uncommitted-living-in-the-link-between-body-image-and-women-s-quality-of-life
#20
Inês A Trindade, Cláudia Ferreira, José Pinto-Gouveia
The current study aimed to test whether the associations of body mass index, body image discrepancy, and social comparison based on physical appearance with women's psychological quality of life (QoL) would be explained by the mechanisms of body image-related experiential avoidance and patterns of uncommitted living. The sample was collected from October 2014 to March 2015 and included 737 female college students (aged between 18 and 25 years) who completed validated self-report measures. Results demonstrated that the final path model explained 43% of psychological QoL and revealed an excellent fit...
December 7, 2016: Women & Health
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