William Laprade, Keirah E Bartlett, Charlotte R Christensen, Taline D Kazandjian, Rohit N Patel, Edouard Crittenden, Charlotte A Dawson, Marjan Mansourvar, Darian S Wolff, Thomas Fryer, Andreas H Laustsen, Nicholas R Casewell, José María Gutiérrez, Steven R Hall, Timothy P Jenkins
Snakebite envenoming is a global public health issue that causes significant morbidity and mortality, particularly in low-income regions of the world. The clinical manifestations of envenomings vary depending on the snake's venom, with paralysis, haemorrhage, and necrosis being the most common and medically relevant effects. To assess the efficacy of antivenoms against dermonecrosis, a preclinical testing approach involves in vivo mouse models that mimic local tissue effects of cytotoxic snakebites in humans...
December 8, 2023: Scientific Reports