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https://www.readbyqxmd.com/read/29025614/outcome-of-distal-tibia-physeal-fractures-a-review-of-cases-as-related-to-risk-factors
#1
Fabio D'Angelo, Giuseppe Solarino, Davide Tanas, Alessia Zani, Paolo Cherubino, Biagio Moretti
INTRODUCTION: The physeal fractures represent the 20-30% of all fractures of the child. The distal tibial physis is the third most frequently injured. The most important complication is the premature physeal closure (PPC). Aim of this study is to evaluate risk factors that can influence the outcome like fracture pattern, fracture displacement, mechanism of injury and treatment method. MATERIAL AND METHODS: The records of 46 patients treated for distal tibia physeal fractures between 2003 and 2013 were reviewed...
October 2017: Injury
https://www.readbyqxmd.com/read/29025611/carbon-fiber-reinforced-intramedullary-nailing-in-musculoskeletal-tumor-surgery-a-national-multicentric-experience-of-the-italian-orthopaedic-society-siot-bone-metastasis-study-group
#2
Andrea Piccioli, Raimondo Piana, Michele Lisanti, Alberto Di Martino, Barbara Rossi, Francesco Camnasio, Marco Gatti, Pietro Maniscalco, Franco Gherlinzoni, Maria Silvia Spinelli, Davide Maria Donati, Roberto Biagini, Rodolfo Capanna, Vincenzo Denaro
INTRODUCTION: Carbon fiber reinforced (CFR) implants have been proposed for the treatment of fractures or impending fractures of the long bones in the oncology patient. Aim of this study is to present the largest cohort of oncology patients operated by CFR nailing by the Italian Orthopaedic Society (SIOT) Bone Metastasis Study Group. METHODS: 53 adult oncology patients were operated on with a CFR-PEEK nail. All the data from adjuvants therapies were collected. Bone callus formation, response to radiotherapy, relapse or progression of the osteolysis were recorded...
October 2017: Injury
https://www.readbyqxmd.com/read/29024060/loss-of-dnmt3b-in-chondrocytes-leads-to-delayed-endochondral-ossification-and-fracture-repair
#3
Cuicui Wang, Yousef Abu-Amer, Regis J O'Keefe, Jie Shen
Despite advanced understanding of signaling mediated by local and systemic factors, the role of epigenetic factors in the regulation of bone regeneration remains vague. The DNA methyltransferases (Dnmts) Dnmt3a and Dnmt3b have tissue specific expression patterns and create unique methylation signatures to regulate gene expression. Using a stabilized murine tibia fracture model we find that Dnmt3b is induced early in fracture healing, peaks at 10 days post fracture (dpf), and declines to nearly undetectable levels by 28 dpf...
October 10, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28992803/collagen-sponge-functionalized-with-chimeric-anti-bmp-2-monoclonal-antibody-mediates-repair-of-nonunion-tibia-defects-in-a-nonhuman-primate-model-an-exploratory-study
#4
Lijia Guo, Seiko Min, Yingying Su, Jianxia Tang, Juan Du, Bee Tin Goh, Leonardo Saigo, Songlin Wang, Sahar Ansari, Alireza Moshaverinia, Homayoun H Zadeh, Yi Liu
Recombinant human bone morphogenetic protein (BMP)-2 is an FDA-approved therapy for nonunion tibia fracture, though it has a number of biological and practical disadvantages. Our research group has developed a novel tissue engineering strategy termed antibody-mediated osseous regeneration. This entails application of anti-BMP-2 monoclonal antibodies (mAbs) to capture endogenous BMP's to mediate in vivo bone formation. This has been documented in a number of animal models. The present exploratory study sought to investigate the application of antibody-mediated osseous regeneration for repair of nonunion tibia defect in a nonhuman primate model...
October 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28986074/finite-element-analysis-of-the-stability-of-ao-ota-43-c1-type-distal-tibial-fractures-treated-with-distal-tibia-medial-anatomic-plate-versus-anterolateral-anatomic-plate
#5
O Fuad Oken, A Ozgur Yildirim, Mehmet Asilturk
BACKGROUND: The treatment of a pilon fracture type is possible from a medial, an anterolateral approach or both medial and lateral. The aim of study was compare the stability of two different plate fixation of a tibia pilon AO-43C1 type fractures. MATERIAL AND METHODS: In this study, three-dimensional finite element stress analysis was applied using isotropic materials and static linear analysis. Loading of 400 N force was applied to the model of a patient fixed in a standing position...
October 3, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28982680/chronic-psychosocial-stress-disturbs-long-bone-growth-in-adolescent-mice
#6
S Foertsch, M Haffner-Luntzer, J Kroner, F Gross, K Kaiser, M Erber, S O Reber, A Ignatius
Although a strong association between psychiatric and somatic disorders is generally accepted, little is known regarding the interrelation between mental and skeletal health. While depressive disorders were shown to be strongly associated with osteoporosis and increased fracture risk, evidence from post-traumatic stress disorder (PTSD) patients is less consistent. Therefore, the present study investigated the influence of chronic psychosocial stress on bone using a well-established murine model for PTSD. 7-week-old C57BL/6N mice were subjected to chronic subordinate colony housing (CSC) for 19 days, whereas control mice were singly housed...
October 5, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28979992/reproduction-differentially-affects-trabecular-bone-depending-on-its-mechanical-versus-metabolic-role
#7
Chantal M J de Bakker, Wei-Ju Tseng, Yihan Li, Hongbo Zhao, Allison R Altman-Singles, Yonghoon Jeong, Juhanna Robberts, Lin Han, Do-Gyoon Kim, X Sherry Liu
During pregnancy and lactation, the maternal skeleton provides calcium for fetal/infant growth, resulting in substantial bone loss, which partially recovers after weaning. However, the amount of bone that is lost and the extent of post-weaning recovery are highly variable among different skeletal sites, and, despite persistent alterations in bone structure at some locations, reproductive history does not increase postmenopausal fracture risk. To explain this phenomenon, we hypothesized that the degree of reproductive bone loss/recovery at trabecular sites may vary depending on the extent to which the trabecular compartment is involved in the bone's load-bearing function...
November 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28979747/diagnostic-accuracy-of-ultrasound-in-upper-and-lower-extremity-long-bone-fractures-of-emergency-department-trauma-patients
#8
Arash Frouzan, Kambiz Masoumi, Ali Delirroyfard, Behnaz Mazdaie, Elnaz Bagherzadegan
BACKGROUND: Long bone fractures are common injuries caused by trauma. Some studies have demonstrated that ultrasound has a high sensitivity and specificity in the diagnosis of upper and lower extremity long bone fractures. OBJECTIVE: The aim of this study was to determine the accuracy of ultrasound compared with plain radiography in diagnosis of upper and lower extremity long bone fractures in traumatic patients. METHODS: This cross-sectional study assessed 100 patients admitted to the emergency department of Imam Khomeini Hospital, Ahvaz, Iran with trauma to the upper and lower extremities, from September 2014 through October 2015...
August 2017: Electronic Physician
https://www.readbyqxmd.com/read/28976591/effect-of-mechanical-strain-on-the-pluripotency-of-murine-embryonic-stem-cells-seeded-in-a-collagen-i-scaffold
#9
Olesja Hazenbiller, Saghar Nasr, Roman J Krawetz, Neil A Duncan
The use of embryonic stem cells (ESC) in regenerative medicine is restricted due to the possibility of tumorigenicity after inefficient or incomplete differentiation. Studies from our group, and others, suggest that mechanical stimuli may have a suppressive effect on the pluripotency/tumorigenesis of murine ESC (mESC). Furthermore, we have demonstrated that mESC seeded in a type I collagen scaffold, and transplanted into a murine bone fracture model, demonstrated repair without tumor formation. However, it remains unknown if mechanical factors were involved in blocking tumorigenicity of the mESC...
October 4, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28960481/comparison-of-the-effects-of-once-weekly-and-once-daily-rhpth-1-34-injections-on-promoting-fracture-healing-in-rodents
#10
Wen Zhang, Junxiong Zhu, Teng Ma, Can Liu, Bao Hai, Guohong Du, Hong Wang, Nan Li, Huijie Leng, Yingsheng Xu, Chunli Song
To compare the efficacy of once-weekly and once-daily subcutaneous injections of teriparatide (recombinant human parathyroid hormone 1-34) on fracture healing, 50 adult male Sprague-Dawley rats were subjected to a unilateral tibia fracture and received internal fixation with a Kirschner needle. Based on the injection dose and frequency, the rats were randomly divided into five groups (n = 10 each): subcutaneous injections of saline or 10 µg/kg/w, 20 µg/kg/w, 10 µg/kg/d and 20 µg/kg/d teriparatide...
September 28, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28956091/strontium-ranelate-stimulates-trabecular-bone-formation-in-a-rat-tibial-bone-defect-healing-process
#11
C Lavet, G Mabilleau, D Chappard, R Rizzoli, P Ammann
Strontium ranelate treatment is known to prevent fractures. Here, we showed that strontium ranelate treatment enhances bone healing and affects bone cellular activities differently in intact and healing bone compartments: Bone formation was increased only in healing compartment, while resorption was reduced in healing and normal bone compartments. INTRODUCTION: Systemic administration of strontium ranelate (SrRan) accelerates the healing of bone defects; however, controversy about its action on bone formation remains...
September 28, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28954524/impact-of-computed-tomography-on-operative-planning-for-ankle-fractures-involving-the-posterior-malleolus
#12
Steven Donohoe, R Kiran Alluri, J Ryan Hill, Mark Fleming, Eric Tan, Geoffrey Marecek
BACKGROUND: The purpose of this study was to (1) Determine the effect of computed tomography (CT) on identification of fractures involving the posterior malleolus, (2) determine its effect on operative indications, and (3) determine its effect on the overall operative plan. METHODS: Patients with ankle fractures involving the posterior malleolus were identified. Only injuries with complete preoperative plain radiographs and a CT scan were included. Spiral tibia fractures and pilon variants were excluded...
September 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28951646/inpatient-orthopaedic-hardware-removal-in-children-a-cross-sectional-study
#13
Alexandre Boulos, Steven F DeFroda, Justin E Kleiner, Nathan Thomas, Joseph A Gil, Aristides I Cruz
INTRODUCTION: Few data describe the specific reasons for inpatient hardware removal in the pediatric population. This study was designed to understand the conditions necessitating inpatient removal following fracture surgery. Cost data was analyzed to understand the financial implications of these procedures. METHODS: The Kids' Inpatient Database (KID) was evaluated for the year 2012. Patients undergoing open reduction internal fixation following upper and lower extremity fractures as well as those undergoing hardware removal due to hardware complications were identified using ICD-9 CM diagnosis and procedure codes...
July 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28948328/open-fracture-management-in-low-resource-settings-a-medical-training-experience-in-cambodian-hospitals
#14
Nenad B Tajsic, Puon Sambath, Sophy Nguon, Vannara Sokh, Virak Chheang, Gaute Landsem, Ivan Zaletel, Hans Husum
INTRODUCTION: A prospective interventional study has been carried out on the teaching effect and sustainability of low-cost trauma training program in open tibia fracture management for health workers. MATERIALS AND METHODS: In 2007, an external fixator and a patella-bearing orthosis were developed at a rural workshop in Cambodia. From 2010 to 2016, a core group of nine Cambodian health workers was trained in open fracture management by Norwegian senior surgeons, using the locally made fixator and brace...
September 25, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28948197/sequential-treatment-with-zoledronic-acid-followed-by-teriparatide-or-vice-versa-increases-bone-mineral-density-and-bone-strength-in-ovariectomized-rats
#15
T Shimizu, T Tanaka, T Kobayashi, I Kudo, M Nakatsugawa, A Takakura, R Takao-Kawabata, T Ishizuya
Bisphosphonates (BPs) and teriparatide (TPTD) are both effective treatments for osteoporosis, but BP treatment prior to daily TPTD treatment has been shown to impair the effect of TPTD in some clinical studies. In contrast, the loss of bone mineral density (BMD) that occurs after withdrawal of TPTD can be prevented by BP treatment. Although various studies have investigated the combination and/or sequential use of BP and TPTD, there have been no clinical studies investigating sequential treatment with zoledronic acid (ZOL) and TPTD (or vice versa)...
December 2017: Bone Reports
https://www.readbyqxmd.com/read/28939032/preoperative-diagnosis-can-predict-conversion-total-knee-arthroplasty-outcomes
#16
David H Ge, Afshin A Anoushiravani, Benjamin S Kester, Jonathan M Vigdorchik, Ran Schwarzkopf
BACKGROUND: Compared to total knee arthroplasty (TKA) for primary osteoarthritis, conversion TKAs in the post-traumatic setting are associated with increased operative times, infection rates, and readmissions. We aim at determining how post-traumatic osteoarthritis and previous knee surgery influence postoperative outcomes in conversion TKA. METHODS: Seventy-two conversion TKA procedures with prior knee trauma at a single institution between April 2012 and 2016 were examined...
August 24, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28938787/influence-of-age-and-housing-systems-on-properties-of-tibia-and-humerus-of-lohmann-white-hens1-bone-properties-of-laying-hens-in-commercial-housing-systems
#17
P Regmi, N Nelson, R C Haut, M W Orth, D M Karcher
This study was aimed at analyzing bone properties of Lohmann White hens in different commercial housing systems at various points throughout production. Pullets reared in conventional cages (CC) were either continued in CC or moved to enriched colony cages (EN) at 19 weeks. Pullets reared in cage-free aviaries (AV) were moved to AV hen houses. Bone samples were collected from 60 hens at each of 18 and 72 wk and 30 hens at 26 and 56 wk from each housing system. Left tibiae and humeri were broken under uniform bending to analyze mechanical properties...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938394/risk-factors-for-failure-of-bone-grafting-of-tibia-nonunions-and-segmental-bone-defects-a-new-preoperative-risk-assessment-score
#18
Michael A Maceroli, Mark J Gage, Brent T Wise, Daniel Connelly, Katherine Ordonio, Renan C Castillo, Molly P Jarman, Jason W Nascone, Robert V OʼToole, Marcus F Sciadini
OBJECTIVE: To develop a clinically useful prediction model of success at the time of surgery to promote bone healing for established tibial nonunion or traumatic bone defects. DESIGN: Retrospective case controlled. SETTING: Level 1 trauma center. PATIENTS: Adult patients treated with surgery for established tibia fracture nonunion or traumatic bone defects from 2007 to 2016. Two hundred three patients met the inclusion criteria and were available for final analysis...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28937802/epidemiology-of-stress-fractures-in-collegiate-student-athletes-2004-2005-through-2013-2014-academic-years
#19
Katherine H Rizzone, Kathryn E Ackerman, Karen G Roos, Thomas P Dompier, Zachary Y Kerr
CONTEXT:   Stress fractures are injuries caused by cumulative, repetitive stress that leads to abnormal bone remodeling. Specific populations, including female athletes and endurance athletes, are at higher risk than the general athletic population. Whereas more than 460 000 individuals participate in collegiate athletics in the United States, no large study has been conducted to determine the incidence of stress fractures in collegiate athletes. OBJECTIVE:   To assess the incidence of stress fractures in National Collegiate Athletic Association (NCAA) athletes and investigate rates and patterns overall and by sport...
September 22, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28932487/intra-articular-fractures-of-the-distal-tibia-current-concepts-of-management
#20
REVIEW
Alexandre Sitnik, Aleksander Beletsky, Steven Schelkun
Results of the treatment of intra-articular fractures of the distal tibia have improved significantly during the last two decades.Recognition of the role of soft tissues has led to the development of a staged treatment strategy. At the first stage, joint-bridging external fixation and fibular fixation are performed. This leads to partial reduction of the distal tibial fracture and allows time for the healing of soft tissues and detailed surgical planning.Definitive open reduction and internal fixation of the tibial fracture is performed at a second stage, when the condition of the soft tissues is safe...
August 2017: EFORT open reviews
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