keyword
https://read.qxmd.com/read/38420368/hemodynamical-behavior-analysis-of-anemic-diabetic-and-healthy-blood-flow-in-the-carotid-artery
#21
JOURNAL ARTICLE
Hashnayne Ahmed, Chinmayee Podder
The influence of blood rheology on hemodynamic parameters is investigated using Computational Fluid Dynamics on blood flow through the human carotid artery. We performed three-dimensional modeling and simulation to study blood flow through the carotid artery, which is divided into internal and exterior parts with a decreased radius. The blood flow was classified as basic pulsatile to simulate the human heart's rhythmic pulses. For hemodynamic modeling viscosity of the fluid, the Carreau model was utilized with four distinct blood instances: Anemic, diabetic, and two healthy blood types...
February 29, 2024: Heliyon
https://read.qxmd.com/read/38420320/video-based-sympathetic-arousal-assessment-via-peripheral-blood-flow-estimation
#22
JOURNAL ARTICLE
Björn Braun, Daniel McDuff, Tadas Baltrusaitis, Christian Holz
Electrodermal activity (EDA) is considered a standard marker of sympathetic activity. However, traditional EDA measurement requires electrodes in steady contact with the skin. Can sympathetic arousal be measured using only an optical sensor, such as an RGB camera? This paper presents a novel approach to infer sympathetic arousal by measuring the peripheral blood flow on the face or hand optically. We contribute a self-recorded dataset of 21 participants, comprising synchronized videos of participants' faces and palms and gold-standard EDA and photoplethysmography (PPG) signals...
December 1, 2023: Biomedical Optics Express
https://read.qxmd.com/read/38418179/-clinical-effect-of-anterolateral-thigh-flow-through-chimeric-perforator-free-flap-transplantation-in-the-treatment-of-upper-limb-complex-tissue-defects-with-main-artery-injury
#23
JOURNAL ARTICLE
F Liu, W Q Yan, Q Ma, Y B Liu, Z B Yang
Objective: To investigate the clinical effect of anterolateral thigh flow-through chimeric perforator free flap transplantation in the treatment of upper limb complex tissue defects with main artery injury. Methods: The study was a retrospective observational study. From May 2019 to January 2022, 11 patients with upper limb complex tissue defects combined with main artery injury who met the inclusion criteria were admitted to the Department of Hand, Foot and Ankle Surgery of General Hospital of Ningxia Medical University, including 7 males and 4 females, aged from 18 to 56 years...
February 20, 2024: Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
https://read.qxmd.com/read/38418174/-effects-of-cerium-oxide-nanoenzyme-gelatin-methacrylate-anhydride-hydrogel-in-the-repair-of-infected-full-thickness-skin-defect-wounds-in-mice
#24
JOURNAL ARTICLE
Y N Gu, X H Xu, Y P Wang, Y T Li, Z Liang, Z Yu, Y Z Peng, B Q Song
Objective: To investigate the effects of cerium oxide nanoenzyme-gelatin methacrylate anhydride (GelMA) hydrogel (hereinafter referred to as composite hydrogel) in the repair of infected full-thickness skin defect wounds in mice. Methods: This study was an experimental study. Cerium oxide nanoenzyme with a particle size of (116±9) nm was prepared by hydrothermal method, and GelMA hydrogel with porous network structure and good gelling performance was also prepared. The 25 μg/mL cerium oxide nanoenzyme which could significantly promote the proliferation of human skin fibroblasts and had high superoxide dismutase activity was screened out...
February 20, 2024: Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi
https://read.qxmd.com/read/38417214/modulation-of-macrophages-by-a-phillyrin-loaded-thermosensitive-hydrogel-promotes-skin-wound-healing-in-mice
#25
JOURNAL ARTICLE
Chenggang Huang, Jiajia Teng, Wei Liu, Junzhe Wang, An Liu
BACKGROUND: Impaired wound healing in traumatic skin injuries remains a severe clinical challenge due to impaired re-vascularization, harmful bacteria infection, and inflammation dysregulation. Macrophages are recognized as prominent immune cells in tissue regeneration and wound healing. Consequently, the modulation of macrophages provides a promising therapeutic target for wound healing disorders. Here, we aimed to explore whether a novel constructed combination of thermosensitive hydrogel Pluronic F-127 (PF-127) and phillyrin (PH, the main active compound of forsythia suspensa) could improve skin wound healing...
February 27, 2024: Cytokine
https://read.qxmd.com/read/38415107/ultrasonic-features-of-automated-breast-volume-scanner-abvs-and-handheld-ultrasound-hhus-combined-with-molecular-biomarkers-in-predicting-axillary-lymph-node-metastasis-of-clinical-t1-t2-breast-cancer
#26
JOURNAL ARTICLE
Jing-Min Li, Yu-Hong Shao, Xiu-Ming Sun, Jian Shi
BACKGROUND: In the post-American College of Surgeons Oncology Group Z0011 trial era, clinicians are attempting to preoperatively evaluate axillary lymph node (ALN) status using ultrasound. However, the value of preoperative ultrasound examination remains uncertain. The study aimed to investigate the ultrasonic features of automated breast volume scanner (ABVS) and handheld ultrasound (HHUS), in combination with molecular biomarkers, to predict the risk of ALN metastasis (ALNM) in clinical T1-T2 breast cancer...
February 1, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38412078/an-implantable-magnetic-drive-mechanism-for-non-invasive-arteriovenous-conduit-blood-flow-control
#27
JOURNAL ARTICLE
Nicholas A White, Sander L van der Kroft, Koen E A van der Bogt, Timo J C Oude Vrielink, Christian Camenzuli, Jean Calleja-Agius, Juan A Sanchez-Margallo, Francisco M Sanchez-Margallo, Huybert J F van de Stadt, Jenny Dankelman, Joris I Rotmans, Tim Horeman
OBJECTIVE: Hemodialysis patients usually receive an arteriovenous fistula (AVF) in the arm as vascular access conduit to allow dialysis 2-3 times a week. This AVF introduces the high flow necessary for dialysis, but over time the ever-present supraphysiological flow is the leading cause of complications. This study aims to develop an implantable device able to non-invasively remove the high flow outside dialysis sessions. METHODS: The developed prototype features a magnetic ring allowing external coupling and torque transmission to non-invasively control an AVF valve...
February 27, 2024: IEEE Transactions on Bio-medical Engineering
https://read.qxmd.com/read/38397024/therapeutic-potential-in-wound-healing-of-allogeneic-use-of-equine-umbilical-cord-mesenchymal-stem-cells
#28
JOURNAL ARTICLE
Ailén Iribarne, María Belén Palma, Laura Andrini, Fernando Riccillo, Delfina Rodriguez, Martín Casella, Felipe Garay, Julieta Spoto Zabala, Leandro Mazza, Adriana Muro, Guillermo Buero, Santiago G Miriuka, Edgardo Carosella, Marcela N García
Wound healing after skin injury is a complex process, particularly in equines where leg wounds are prevalent and their repair is complicated due to the anatomical characteristics. Conventional treatments are not effective enough. The umbilical cord offers an unlimited source of adult mesenchymal stem cells (ucMSCs) from Wharton's jelly tissue. The present study aims to demonstrate the safety and therapeutic potential of the allogeneic use of equine ucMSCs (e-ucMSCs) in the healing of severe equine leg wounds...
February 16, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38390315/a-portable-optical-pulsatile-flowmetry-demonstrates-strong-clinical-relevance-for-diabetic-foot-perfusion-assessment
#29
JOURNAL ARTICLE
Renzhe Bi, Ruochong Zhang, Lingyan Meng, Yao Du, Julie Low, Yi Qi, Poongkulali Rajarahm, Alexis Yuen Fun Lai, Victoria Shi Ying Tan, Pei Ho, Malini Olivo
We present a robust, cost-effective (<2000 USD), and portable optical diffuse speckle pulsatile flowmetry (DSPF) device with a flexible handheld probe for deep tissue blood flow measurement in the human foot as well as a first-in-man observational clinical study using the proposed optical device for tissue ischemia assessment and peripheral artery disease (PAD) diagnosis. Blood flow in tissue is inherently pulsatile in nature. However, most conventional methods cannot measure deep tissue-level pulsatile blood flow noninvasively...
March 2024: APL Bioengineering
https://read.qxmd.com/read/38388759/observations-of-cold-induced-vasodilation-in-persons-with-spinal-cord-injuries
#30
JOURNAL ARTICLE
Yasuhisa Fujita, Yoshi-Ichiro Kamijo, Tokio Kinoshita, Takamasa Hashizaki, Kouta Murai, Tatsuya Yoshikawa, Yasunori Umemoto, Chikako Kaminaka, Manabu Shibasaki, Fumihiro Tajima, Yukihide Nishimura
STUDY DESIGN: Acute experimental study. OBJECTIVES: Cold-induced vasodilation is a local mechanism of protection against frostbite in non-injured persons. We assessed whether an increase in skin blood flow (SkBF) during local cooling (LC) was observed in individuals with spinal cord injuries (SCIs) and if the response patterns differed between region levels or sites. SETTING: Laboratory of Wakayama Medical University and the affiliated clinics, Japan...
February 22, 2024: Spinal Cord
https://read.qxmd.com/read/38379484/impact-of-topical-capsaicin-cream-on-thermoregulation-and-perception-while-walking-in-the-cold
#31
JOURNAL ARTICLE
Alejandro M Rosales, Jessica L Moler, Andrew C Engellant, Alice L Held, Dustin R Slivka
INTRODUCTION: Capsaicin, a chili pepper extract, can stimulate increased skin blood flow (SkBF) with a perceived warming sensation on application areas. Larger surface area application may exert a more systemic thermoregulatory response. Capsaicin could assist with maintaining heat transport to the distal extremities, minimizing cold weather injury risk. However, the thermoregulatory and perceptual impact of topical capsaicin cream application prior to exercise in the cold is unknown...
January 22, 2024: Wilderness & Environmental Medicine
https://read.qxmd.com/read/38378732/microcirculatory-changes-in-the-skin-after-postmastectomy-radiotherapy-in-women-with-breast-cancer
#32
JOURNAL ARTICLE
Sherif Elawa, Robin Mirdell, Aristotelis Stefanis, Erik Tesselaar, Simon Farnebo
Postmastectomy radiotherapy (PMRT) increases the risk for complications after breast reconstruction. The pathophysiological mechanism underlying this increased risk is not completely understood. The aim of this study was to examine if there is a relationship between PMRT and microvascular perfusion in the skin directly after, and at 2 and 6 months after PMRT and to assess if there is impaired responsiveness to a topically applied vasodilator (Methyl nicotinate-MN) after PMRT. Skin microvascular responses after PMRT were measured on two sites in the irradiated chest wall of 22 women before, immediately after, and at 2 and 6 months after unilateral PMRT with the contralateral breast as a control...
February 20, 2024: Scientific Reports
https://read.qxmd.com/read/38377858/erk-stat3-activation-through-ccl17-ccr4-axis-mediated-type-2-cytokine-involved-signaling-pathways-in-th2-cells-regulates-cutaneous-drug-reactions
#33
JOURNAL ARTICLE
Jun-Ting Tang, Kai-Cheng Gao, Yi Zhang, Xiao-Yan Zhou, Lu-Hui Yang, Yi-Qun Kuang, Yu-Ye Li
Cutaneous drug reactions (CDRs) are common drug-induced allergic reactions that cause severe consequences in HIV/AIDS patients. The CCL17/CCR4 axis is involved in the immune mechanism of allergic diseases, but its role in the CDRs has not been determined. Here, we aimed to determine the role of the CCL17/CCR4 axis and the underlying mechanism involved in CDRs. In this study, the serum cytokine levels in patients with CDR and healthy controls were measured. The CCL17-triggered allergic profile was screened via a PCR array...
February 19, 2024: International Immunopharmacology
https://read.qxmd.com/read/38375226/-in%C3%A2-vivo-laser-speckle-contrast-imaging-of-microvascular-blood-perfusion-using-a-chip-on-tip-camera
#34
JOURNAL ARTICLE
Lukas Markwalder, Rodney Gush, Faisel Khan, Colin E Murdoch, Nikola Krstajić
Laser speckle contrast imaging (LSCI) is an important non-invasive capability for real-time imaging for tissue-perfusion assessment. Yet, the size and weight of current clinical standard LSCI instrumentation restricts usage to mainly peripheral skin perfusion. Miniaturization of LSCI could enable hand-held instrumentation to image internal organ/tissue to produce accurate speckle-perfusion maps. We characterized a 1mm2 chip-on-tip camera for LSCI of blood perfusion in vivo and with a flow model. A dedicated optical setup was built to compare chip-on-tip camera to a high specification reference camera (GS3) for LSCI...
March 15, 2024: IScience
https://read.qxmd.com/read/38372608/-a-clinical-case-of-piloleiomyoma
#35
JOURNAL ARTICLE
N S Alekseeva, A A Ivina, A G Nadtochiy, I I Babichenko
The article describes a clinical case of a benign tumor from smooth muscle cells - piloleiomyoma. The incidence of leiomyoma in the skin is 3-5% of all leiomyomas. A 27-year-old patient applied to a medical institution with complaints about an intradermal formation in the ear region that occurred repeatedly within 5 months after surgical treatment. After the first surgical intervention, the patient was consulted in various medical organizations, where the following diagnoses were made: «nodular fasciitis», «smooth muscle tumor without signs of malignancy» and «non-epithelial spindle cell neoplasm»...
2024: Stomatologii︠a︡
https://read.qxmd.com/read/38367251/hormonal-intrauterine-devices-and-heat-exchange-during-exercise
#36
JOURNAL ARTICLE
Nathalie V Kirby, Robert D Meade, Brodie J Richards, Sean R Notley, Glen P Kenny
Synthetic progestins in oral contraceptives are thought to blunt heat dissipation by reducing skin blood flow and sweating. However, whether progestin-releasing intrauterine devices (IUDs) modulate heat loss during exercise-heat stress is unknown. We used direct calorimetry to measure whole-body total (dry + evaporative) heat loss in young, physically active women (mean (SD); aged 24 (4) years, <mml:math xmlns:mml="https://www.w3.org/1998/Math/MathML"> <mml:semantics> <mml:msub><mml:mover><mml:mi>V</mml:mi> <mml:mo>̇</mml:mo></mml:mover> <mml:mrow><mml:msub><mml:mi>O</mml:mi> <mml:mn>2</mml:mn></mml:msub> <mml:mi>peak</mml:mi></mml:mrow> </mml:msub> <mml:annotation>${\dot V_{{{\mathrm{O}}_{\mathrm{2}}}{\mathrm{peak}}}}$</mml:annotation></mml:semantics> </mml:math> 39...
February 17, 2024: Journal of Physiology
https://read.qxmd.com/read/38366149/predicting-human-dermal-drug-concentrations-using-pbpk-modeling-and-simulation-clobetasol-propionate-case-study
#37
JOURNAL ARTICLE
William W van Osdol, Jasmina Novakovic, Maxime Le Merdy, Eleftheria Tsakalozou, Priyanka Ghosh, Jessica Spires, Viera Lukacova
Quantitative in silico tools may be leveraged to mechanistically predict the dermato-pharmacokinetics of compounds delivered from topical and transdermal formulations by integrating systems of rate equations that describe permeation through the formulation and layers of skin and pilo-sebaceous unit, and exchange with systemic circulation via local blood flow. Delivery of clobetasol-17 propionate (CP) from DermovateTM cream was simulated using the Transdermal Compartmental Absorption & Transit (TCATTM ) Model in GastroPlus® ...
February 17, 2024: AAPS PharmSciTech
https://read.qxmd.com/read/38365092/reticulated-livedoid-skin-patterns-after-soft-tissue-filler-related-vascular-adverse-events
#38
JOURNAL ARTICLE
L W Schelke, P J Velthuis, A Mojallal, G Henry, S O P Hofer, S C Cotofana
BACKGROUND: For the treatment of vascular adverse events caused by filler injections, duplex ultrasound imaging may be used. The findings of duplex ultrasound examination and the clinical features of reticulated livedoid skin patterns were compared to the hemifaces anatomy. OBJECTIVE: to link the reticulated livedoid skin patterns, to the corresponding duplex ultrasound findings and the facial perforasomes. METHODS: duplex ultrasound imaging was used for diagnosis and treatment of vascular adverse events...
February 14, 2024: Journal of the American Academy of Dermatology
https://read.qxmd.com/read/38357060/painful-tender-localized-idiopathic-livedo-reticularis
#39
Yanci A Algarin, Robert Pariser
Livedo reticularis (LR) is a unique cutaneous condition characterized by a reddish-blue to purple, net-like cyanosis of the skin, often associated with disturbances in cutaneous blood flow. This case report discusses a 30-year-old woman with a history of Hashimoto thyroiditis, vitamin D deficiency, migraines, and goiter who presents with painful, localized LR on her right flank. Despite her extensive medical history, there were no significant findings in her laboratory and imaging studies, including a normal epidermis in skin biopsies...
January 2024: Curēus
https://read.qxmd.com/read/38356253/effects-of-alternating-pressure-patterns-on-sacral-skin-blood-flow-responses-in-people-with-spinal-cord-injury
#40
JOURNAL ARTICLE
Serah Pauly, Pu-Chun Mo, Jeannette Elliott, Adam Bleakney, Suguna Pappu, Yih-Kuen Jan
Alternating pressure support surface (APSS) is a common support surface for treating pressure injury in individuals with spinal cord injury (SCI). However, conflicting results on the effectiveness of APSS have been reported and may be associated with inappropriate configurations of APSS. The objectives of this study were to compare the different pressure amplitudes (75/5 mmHg [alternating between 75 and 5 mmHg] vs. 65/15 mmHg) and cycle periods (5 min [4 cycles] vs. 2.5 min [8 cycles]) of alternating pressure on sacral skin blood flow responses in 10 individuals with SCI...
February 2024: International Wound Journal
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