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Pregnancy simulation

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https://www.readbyqxmd.com/read/27891739/acardiac-twin-pregnancies-part-iv-acardiac-onset-from-unequal-embryonic-splitting-simulated-by-a-fetoplacental-resistance-model
#1
Martin J C van Gemert, Jeroen P H M van den Wijngaard, K Marieke Paarlberg, Helena M Gardiner, Peter G J Nikkels
BACKGROUND: Benirschke postulated that acardiac twinning occurs when markedly unequal embryonic splitting combines with arterioarterial (AA) and venovenous placental anastomoses. We tested this hypothesis by model simulations and by comparison of outcomes with 18 "pseudo-" (twin fetus with beating heart but otherwise with clear signs of an acardiac) and 3 "normal" acardiac cases. METHODS: The smaller/larger cell volume ratio at embryonic splitting becomes the smaller/larger embryonic/fetal blood volume ratio (a)...
November 28, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27887718/novel-centrifugal-technology-for-measuring-sperm-concentration-in-the-home
#2
Ulrich Y Schaff, Laura L Fredriksen, Jon G Epperson, Tiffany R Quebral, Sara Naab, Mark J Sarno, Michael L Eisenberg, Greg J Sommer
OBJECTIVE: To evaluate the analytical performance and usability of the Trak Male Fertility Testing System, a semiquantitative (categorical) device recently US Food and Drug Administration (FDA)-cleared for measuring sperm concentration in the home by untrained users. DESIGN: A three-site clinical trial comparing self-reported lay user results versus reference results obtained by computer-aided semen analysis (CASA). SETTING: Simulated home use environments at fertility centers and urologist offices...
November 22, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27875431/do-infant-simulators-deter-teen-pregnancy
#3
Joan Zolot
Study shows girls who took simulators home had higher subsequent pregnancy rates.
December 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27866752/selling-antimicrobials-without-prescription-far-beyond-an-administrative-problem
#4
Maria C Guinovart, Albert Figueras, Carles Llor
INTRODUCTION: Selling antibiotics without prescription is common in many countries; beyond the administrative restrictions, this practice is a risk for patients and society. The aim of the study was to evaluate the information provided by the staff of the pharmacy to a simulated patient requesting an antibiotic. MATERIAL AND METHODS: A prospective study was carried out in January 2013 - February 2014 in the Health Region of Tarragona, in which a mystery shopper visited 220 pharmacies requesting an antibiotic to be sold...
November 17, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27854395/prediction-of-stillbirth-from-placental-growth-factor-at-19-24-weeks
#5
J E Aupont, R Akolekar, A Illian, S Neonakis, K H Nicolaides
OBJECTIVES: To investigate whether the addition of maternal serum placental growth factor (PlGF) measured at 19-24 weeks' gestation improves the performance of screening for stillbirth that is achieved by a combination of maternal factors, fetal biometry and uterine artery pulsatility index (UtA-PI) and to evaluate the performance of screening with this model for all stillbirths and those due to impaired placentation and unexplained or other causes. METHODS: This was a prospective screening study of 70 003 singleton pregnancies including 268 stillbirths, carried out in two phases...
November 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27836979/a-mild-ovarian-stimulation-strategy-in-women-with-poor-ovarian-reserve-undergoing-ivf-a-multicenter-randomized-non-inferiority-trial
#6
M A Youssef, M van Wely, H Al-Inany, T Madani, N Jahangiri, S Khodabakhshi, M Alhalabi, M Akhondi, S Ansaripour, R Tokhmechy, L Zarandi, A Rizk, M El-Mohamedy, E Shaeer, M Khattab, M H Mochtar, F van der Veen
STUDY QUESTION: In subfertile women with poor ovarian reserve undergoing IVF does a mild ovarian stimulation strategy lead to comparable ongoing pregnancy rates in comparison to a conventional ovarian stimulation strategy? SUMMARY ANSWER: A mild ovarian stimulation strategy in women with poor ovarian reserve undergoing IVF leads to similar ongoing pregnancy rates as a conventional ovarian stimulation strategy. WHAT IS KNOWN ALREADY: Women diagnosed with poor ovarian reserve are treated with a conventional ovarian stimulation strategy consisting of high-dose gonadotropins and pituitary downregulation with a long mid-luteal start GnRH-agonist protocol...
November 11, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27788214/image-based-modeling-of-blood-flow-and-oxygen-transfer-in-feto-placental-capillaries
#7
Philip Pearce, Paul Brownbill, Jiří Janáček, Marie Jirkovská, Lucie Kubínová, Igor L Chernyavsky, Oliver E Jensen
During pregnancy, oxygen diffuses from maternal to fetal blood through villous trees in the placenta. In this paper, we simulate blood flow and oxygen transfer in feto-placental capillaries by converting three-dimensional representations of villous and capillary surfaces, reconstructed from confocal laser scanning microscopy, to finite-element meshes, and calculating values of vascular flow resistance and total oxygen transfer. The relationship between the total oxygen transfer rate and the pressure drop through the capillary is shown to be captured across a wide range of pressure drops by physical scaling laws and an upper bound on the oxygen transfer rate...
2016: PloS One
https://www.readbyqxmd.com/read/27784094/caring-for-realistic-infant-simulators-does-not-deter-teenage-pregnancy
#8
Anita Slomski
No abstract text is available yet for this article.
October 25, 2016: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/27773713/reassessing-the-importance-of-long-acting-contraception
#9
Quentin C Karpilow, Adam T Thomas
BACKGROUND: Several recent studies have highlighted the need for greater use of long-acting contraception. The most influential of these studies is the Contraceptive CHOICE Project, which was credited with substantially reducing participants' pregnancy risk by increasing their use of long-acting methods such as intrauterine devices and subdermal implants. However, because participants' rates of nonuse and condom use fell to zero at the outset of the intervention, it is possible that sizeable pregnancy reductions could still have been achieved if enrollees had chosen shorter-acting female-controlled methods such as oral contraception...
October 20, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27769989/statistical-methods-for-unusual-count-data-examples-from-studies-of-microchimerism
#10
Katherine A Guthrie, Hilary S Gammill, Mads Kamper-Jørgensen, Anne Tjønneland, Vijayakrishna K Gadi, J Lee Nelson, Wendy Leisenring
Natural acquisition of small amounts of foreign cells or DNA, referred to as microchimerism, occurs primarily through maternal-fetal exchange during pregnancy. Microchimerism can persist long-term and has been associated with both beneficial and adverse human health outcomes. Quantitative microchimerism data present challenges for statistical analysis, including a skewed distribution, excess zero values, and occasional large values. Methods for comparing microchimerism levels across groups while controlling for covariates are not well established...
October 21, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27765195/managing-pregnancy-as-an%C3%A2-interventional%C3%A2-cardiologist-fellow-in-training-my-experience-with-a-simulator
#11
Marie Hauguel-Moreau, Julien Adjedj
No abstract text is available yet for this article.
October 25, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27755062/amniotic-fluid-embolism
#12
Courtney Stanley Sundin, Lauren Bradham Mazac
Amniotic fluid embolism (AFE) is a rare but serious and potentially deadly complication of pregnancy that is unpreventable and unpredictable. Most AFE events occur during labor; however, approximately one third happen during the immediate postpartum period. Presentation is abrupt and thought to be an abnormal response to fetal materials entering maternal circulation through the placental insertion site. Care providers must recognize the signs and symptoms of AFE and react quickly in effort to treat potential complications...
October 13, 2016: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/27737599/budget-impact-analysis-of-sflt-1-plgf-ratio-as-prediction-test-in-italian-women-with-suspected-preeclampsia
#13
Tiziana Frusca, Maria-Teresa Gervasi, Davide Paolini, Matteo Dionisi, Francesca Ferre, Irene Cetin
INTRODUCTION: Preeclampsia (PE) is a pregnancy disease which represents a leading cause of maternal and perinatal mortality and morbidity. Accurate prediction of PE risk could provide an increase in health benefits and better patient management. OBJECTIVE: To estimate the economic impact of introducing Elecsys sFlt-1/PlGF ratio test, in addition to standard practice, for the prediction of PE in women with suspected preeclampsia in the Italian NHS. METHODS: A decision tree model has been developed to simulate the progression of a cohort of pregnant women from the first presentation of clinical suspicion of PE in the 2nd and 3rd trimester until delivery...
October 13, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27726304/simulation-based-team-training-for-multi-professional-obstetric-care-teams-to-improve-patient-outcome-a-multicentre-cluster-randomised-controlled-trial
#14
A F Fransen, J van de Ven, E Schuit, Aac van Tetering, B W Mol, S G Oei
OBJECTIVE: To investigate whether simulation-based obstetric team training in a simulation centre improves patient outcome. DESIGN: Multicentre, open, cluster randomised controlled trial. SETTING: Obstetric units in the Netherlands. POPULATION: Women with a singleton pregnancy beyond 24 weeks of gestation. METHODS: Random allocation of obstetric units to a 1-day, multi-professional, simulation-based team training focusing on crew resource management (CRM) in a simulation centre or to no such team training...
October 10, 2016: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27685488/early-pregnancy-ultrasound-and-management-effect-of-a-multifaceted-training-on-physician-knowledge
#15
B O'Leary, A Khalid, M Higgins
Vaginal bleeding is a common event in early pregnancy, with 20-40% of pregnancies affected. Prompt diagnosis and management of bleeding is important, both to reduce morbidity and to avoid excessive emotional distress. This was a prospective study of an educational programme aimed at Obstetrics and Gynaecology BST trainees in the National Maternity Hospital, Dublin. The educational programme consisted of didactic lectures, and simulation and practical sessions. A questionnaire reviewing early pregnancy complications was used to assess participant knowledge...
2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27685136/spot-scanning-proton-therapy-minimizes-neutron-dose-in-the-setting-of-radiation-therapy-administered-during-pregnancy
#16
Xin Wang, Falk Poenisch, Narayan Sahoo, Ronald X Zhu, MingFwu Lii, Michael T Gillin, Jing Li, David Grosshans
This is a real case study to minimize the neutron dose equivalent (H) to a fetus using spot scanning proton beams with favorable beam energies and angles. Minimum neutron dose exposure to the fetus was achieved with iterative planning under the guidance of neutron H measurement. Two highly conformal treatment plans, each with three spot scanning beams, were planned to treat a 25-year-old pregnant female with aggressive recurrent chordoma of the base of skull who elected not to proceed with termination. Each plan was scheduled for delivery every other day for robust target coverage...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27663678/cost-effectiveness-of-intermittent-screening-followed-by-treatment-versus-intermittent-preventive-treatment-during-pregnancy-in-west-africa-analysis-and-modelling-of-results-from-a-non-inferiority-trial
#17
Silke Fernandes, Elisa Sicuri, Diawara Halimatou, James Akazili, Kalifa Boiang, Daniel Chandramohan, Sheikh Coulibaly, Sory Ibrahim Diawara, Kassoum Kayentao, Feiko Ter Kuile, Pascal Magnussen, Harry Tagbor, John Williams, Arouna Woukeu, Matthew Cairns, Brian Greenwood, Kara Hanson
BACKGROUND: Emergence of high-grade sulfadoxine-pyrimethamine (SP) resistance in parts of Africa has led to growing concerns about the efficacy of intermittent preventive treatment of malaria during pregnancy (IPTp) with SP. The incremental cost-effectiveness of intermittent screening and treatment (ISTp) with artemether-lumefantrine (AL) as an alternative strategy to IPTp-SP was estimated followed by a simulation of the effects on cost-effectiveness of decreasing efficacy of IPTp-SP due to SP resistance...
2016: Malaria Journal
https://www.readbyqxmd.com/read/27661999/furthering-the-validity-of-a-tool-to-assess-simulated-pregnancy-options-counseling-skills
#18
Carla Lupi, Melissa Ward-Peterson, Stefany Coxe, Suzanne Minor, Irmanie Eliacin, Vivian Obeso
OBJECTIVE: To further the validity of a tool to assess nondirective pregnancy options counseling skills. METHODS: Using a cross-sectional design, we explored four sources of construct validity evidence for an objective structured clinical examination for training and assessment of nondirective pregnancy options counseling: content, response process, internal structure, and relations to other variables. Content of the previously developed tool was enhanced through input from five family medicine educators...
October 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27645287/radiation-doses-for-pregnant-women-in-the-late-pregnancy-undergoing-fetal-computed-tomography-a-comparison-of-dosimetry-and-monte-carlo-simulations
#19
Yuta Matsunaga, Ai Kawaguchi, Masanao Kobayashi, Shigetaka Suzuki, Shoichi Suzuki, Koichi Chida
The purposes of this study were (1) to compare the radiation doses for 320- and 80-row fetal-computed tomography (CT), estimated using thermoluminescent dosimeters (TLDs) and the ImPACT Calculator (hereinafter referred to as the "CT dosimetry software"), for a woman in her late pregnancy and her fetus and (2) to estimate the overlapped fetal radiation dose from a 320-row CT examination using two different estimation methods of the CT dosimetry software. The direct TLD data in the present study were obtained from a previous study...
September 19, 2016: Radiological Physics and Technology
https://www.readbyqxmd.com/read/27633979/is-there-a-critical-period-for-the-developmental-neurotoxicity-of-low-level-tobacco-smoke-exposure
#20
Theodore A Slotkin, Ashley Stadler, Samantha Skavicus, Jennifer Card, Jonathan Ruff, Edward D Levin, Frederic J Seidler
Secondhand tobacco smoke exposure in pregnancy increases the risk of neurodevelopmental disorders. We evaluated in rats whether there is a critical period during which tobacco smoke extract (TSE) affects the development of acetylcholine and serotonin systems, prominent targets for adverse effects of nicotine and tobacco smoke. We simulated secondhand smoke exposure by administering TSE so as to produce nicotine concentrations one-tenth those in active smoking, with three distinct, ten-day windows: premating, early gestation or late gestation...
September 14, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
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