keyword
MENU ▼
Read by QxMD icon Read
search

HCC signaling pathway

keyword
https://www.readbyqxmd.com/read/28077802/nmi-promotes-hepatocellular-carcinoma-progression-via-bdkrb2-and-mapk-erk-pathway
#1
Jing Zhao, Qiong-Zhu Dong, Fan Zhong, Li-Li Cai, Zhao-Yu Qin, Yang Liu, Cheng-Zhao Lin, Lun-Xiu Qin, Fu-Chu He
Hepatocellular carcinoma (HCC) is one of the most prevalent and aggressive malignant tumors. The involvement of N-myc (and STAT) interactor (NMI) and its possible functional mechanisms in HCC progression still remain to be elucidated. In this study, we found that NMI was overexpressed in metastatic HCC cell lines compared with non-metastatic ones; and the expression levels of NMI in the HCC samples with metastasis were higher than that in the non-metastatic specimens. Furthermore, NMI depletion significantly decreased HCC cell proliferation and invasiveness in vitro, and also inhibited tumor growth and lung metastasis in vivo in nude mice models bearing human HCC...
January 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28076852/mir-874-3p-is-down-regulated-in-hepatocellular-carcinoma-and-negatively-regulates-pin1-expression
#2
Ka-Wai Leong, Chi-Wai Cheng, Chun-Ming Wong, Irene Oi-Lin Ng, Yok-Lam Kwong, Eric Tse
PIN1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that regulates multiple signaling pathways to control cell fate and is found to be over-expressed in cancers, including hepatocellular carcinoma (HCC). However, the regulation of PIN1 in HCC remains poorly defined. Micro-RNAs (miRNAs) have been reported to play a pivotal role in oncogenesis by targeting the 3'-untranslated region (UTR) of mRNAs encoded by oncogenes and tumour suppressor genes, thereby suppressing the levels of both oncoproteins and tumour suppressors...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28076850/transforming-growth-factor-beta1-suppresses-hepatocellular-carcinoma-proliferation-via-activation-of-hippo-signaling
#3
Xiaodong Zhang, Qing Fan, Yan Li, Zhaoguo Yang, Liang Yang, Zhihong Zong, Biao Wang, Xin Meng, Qin Li, Jingang Liu, Hangyu Li
In this study, we examined the expression of core proteins of the Hippo signaling pathway in hepatocellular carcinoma (HCC) cells treated with transforming growth factor-β 1(TGF-β1) and investigated the relationship between TGF-β1 and the Hippo signaling pathway, in order to better understand their roles in HCC and their potential implications for cancer therapy. We prove that the Hippo signaling pathway is involved in the TGF-β1-induced inhibition of the growth of HCC cells. Large tumor suppressor expression (LATS1) was overexpression and yes association protein 1(YAP1) translocated from the nucleus to the cytoplasm in HCC cells treated with TGF-β1...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28075467/resveratrol-suppresses-human-hepatocellular-carcinoma-via-targeting-hgf-c-met-signaling-pathway
#4
Feng Gao, Gang Deng, Wenbin Liu, Kechao Zhou, Ming Li
Resveratrol, one of the major polyphenols found in red wine, is suggested to have a role as a chemo-prevention or chemotherapy agent in various human cancer models. Herein, we report that resveratrol has a profound antitumor effect on human hepatocellular carcinoma (HCC) cells by down-regulation of the HGF-c-Met signaling pathway. Resveratrol inhibited anchorage-dependent and -independent growth of HCC cells in a dose-dependent manner. Short-term resveratrol exposure substantially decreased HGF-induced c-Met signaling pathway activation, and long-term exposure to resveratrol markedly inhibited c-Met expression on the cell membrane...
January 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28074862/hypoxia-activates-wnt-%C3%AE-catenin-signaling-by-regulating-the-expression-of-bcl9-in-human-hepatocellular-carcinoma
#5
Wei Xu, Wang Zhou, Mo Cheng, Jing Wang, Zhian Liu, Shaohui He, Xiangji Luo, Wending Huang, Tianrui Chen, Wangjun Yan, Jianru Xiao
The Wnt/β-catenin signaling is abnormally activated in the progression of hepatocellular carcinoma (HCC). BCL9 is an essential co-activator in the Wnt/β-catenin signaling. Importantly, BCL9 is absent from tumors originating from normal cellular counterparts and overexpressed in many cancers including HCC. But the mechanism for BCL9 overexpression remains unknown. Ample evidence indicates that hypoxia inducible factors (HIFs) play a role in the development of HCC. It was found in our study that BCL9 was overexpressed in both primary HCC and bone metastasis specimens; loss of BCL9 inhibited the proliferation, migration and angiogenesis of HCC; and that that hypoxia mechanically induced the expression of BCL9...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073674/inhibition-of-invasion-by-n-trans-feruloyloctopamine-via-akt-p38mapk-and-emt-related-signals-in-hepatocellular-carcinoma-cells
#6
Zhong-Tian Bai, Zheng-Rong Wu, Li-Li Xi, Xun Li, Peng Chen, Fu-Qiang Wang, Wen-Bo Meng, Wen-Ce Zhou, Xin-An Wu, Xiao-Jun Yao, Min Zhang
N-trans-feruloyloctopamine (FO) isolated from Garlic skin was identified as the primary antioxidant constituents, however, the effect of which on HCC invasion is still unclear. Herein, the FO was synthesized and its antitumor activities were evaluated in HCC cell lines. Cellular functional analyses have revealed that the reformed FO owns strong abilities of inhibiting cell proliferation and invasion in HCC cells. Molecular data have further showed that FO could significantly decrease the phosphorylation levels of Akt and p38 MAPK...
December 30, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28065785/a-positive-feedback-loop-between-ros-and-mxi1-0-promotes-hypoxia-induced-vegf-expression-in-human-hepatocellular-carcinoma-cells
#7
Zhenzhen Hu, Na Dong, Dian Lu, Xiuqin Jiang, Jinjin Xu, Zhiwei Wu, Datong Zheng, Daniel S Wechsler
VEGF expression induced by hypoxia plays a critical role in promoting tumor angiogenesis. However, the molecular mechanism that modulates VEGF expression under hypoxia is still poorly understood. In this study, we found that VEGF induction in hypoxic HepG2 cells is ROS-dependent. ROS mediates hypoxia-induced VEGF by upregulation of Mxi1-0. Furthermore, PI3K/AKT/HIF-1α signaling pathway is involved in ROS-mediated Mxi1-0 and VEGF expression in hypoxic HepG2 cells. Finally, Mxi1-0 could in turn regulate ROS generation in hypoxic HepG2 cells, creating a positive feedback loop...
January 6, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28061318/hepatitis-b-surface-antigen-promotes-the-invasion-of-hepatitis-b-virus-related-hepatocellular-carcinoma-cells-by-upregulation-of-toll-like-receptor-2
#8
Shan Cheng, Bin Zhang, Ji-Ying Du, Yu-Hong Jin, Hai-Yang Lang, Li-Hua Zeng
Hepatitis B virus (HBV) infection is one of the major risk factors leading to the development of hepatocellular carcinoma (HCC). Hepatitis B surface antigen (HBsAg) plays a pivotal role in HBV-related HCC pathogenesis, and Toll-like receptor (TLR) 2 is also considered to mediate tumor progression. However, the interaction between HBsAg and TLR2 in HCC progression remains unclear. Thus, the aim of the study was to explore the effect of HBsAg-TLR2 pathway on growth and invasion of HBV-related HCC cells and examine the potential mechanisms been involved...
January 6, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28058860/liposome-mediated-rna-interference-delivery-against-erk1-and-erk2-does-not-equally-promote-chemosensitivity-in-human-hepatocellular-carcinoma-cell-line-hepg2
#9
Amir Mehdizadeh, Mohammad Hossein Somi, Masoud Darabi, Safar Farajnia, Abolfazl Akbarzadeh, Soheila Montazersaheb, Mehdi Yousefi, Mortaza Bonyadi
BACKGROUND: Extracellular signal-regulated kinase (Erk)1 and Erk2 are central mediators of mitogen-activated protein kinase signaling pathway, which plays a key role in proliferation and chemoresistance of cancer cells. However, the effect of Erk1 and Erk2 in these processes may not be the same. The aim of this study was to investigate differential effect of Erk1 and Erk2 down-regulation on chemoresistance in human hepatocellular carcinoma (HCC) cells. Expression level and relative expression analysis in HepG2 cells were performed using RT-PCR and qRT-PCR, respectively...
January 6, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28051262/bioinformatic-identification-of-igf1-as-a-hub-gene-in-hepatocellular-carcinoma-hcc-and-in-vitro-analysis-of-the-chemosensitizing-effect-of-mir-379-via-suppressing-the-igf1-igf1r-signaling-pathway
#10
D-J Huang, J-Z Huang, J Yang, Y-H Li, Y-C Luo, H-Y He, H-J Huang
OBJECTIVE: We investigated the interactions among the dysregulated genes in hepatocellular carcinoma (HCC) and identified the hub genes in the protein-protein interaction (PPI) network. Also, we also investigated the regulative effect of miR-379 on the IGF1/IGF1R signaling pathway and chemoresistance in HCC. MATERIALS AND METHODS: Raw data of a microarray that compared transcriptional gene profile between 3-paired HCC tissue samples and adjacent normal tissues were downloaded from Expression Atlas (E-GEOD-33006)...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28043148/analysis-of-differentially-co-expressed-genes-based-on-microarray-data-of-hepatocellular-carcinoma
#11
Y Wang, T Jiang, Z Li, L Lu, R Zhang, D Zhang, X Wang, J Tan
Hepatocellular carcinoma (HCC) is the third leading cause of cancer related death worldwide. Although great progress in diagnosis and management of HCC have been made, the exact molecular mechanisms remain poorly understood. The study aims to identify potential biomarkers for HCC progression, mainly at transcription level. In this study, chip data GSE 29721 was utilized, which contains 10 HCC samples and 10 normal adjacent tissue samples. Differentially expressed genes (DEGs) between two samples types were selected by t-test method...
January 3, 2017: Neoplasma
https://www.readbyqxmd.com/read/28042950/ccl24-contributes-to-hcc-malignancy-via-rhob-vegfa-vegfr2-angiogenesis-pathway-and-indicates-poor-prognosis
#12
Lei Jin, Wei-Ren Liu, Meng-Xin Tian, Xi-Fei Jiang, Han Wang, Pei-Yun Zhou, Zhen-Bin Ding, Yuan-Fei Peng, Zhi Dai, Shuang-Jian Qiu, Jian Zhou, Jia Fan, Ying-Hong Shi
CCL24 is one chemotactic factor extensively studied in airway inflammation and colorectal cancer but less studied in hepatocellular carcinoma (HCC) retrospectively. So HCC tissue microarray (TMA) was used to estimate relationship between CCL24 and prognosis, cell experiments were conducted to study its influence for HCC cell biological behavior. CCL24 was injected to nude mice to monitor tumor formation and pulmonary metastasis; qRT-PCR, western blot and Immunohistochemistry were used to explore potential mechanism...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28035485/action-and-function-of-wnt-%C3%AE-catenin-signaling-in-the-progression-from-chronic-hepatitis-c-to-hepatocellular-carcinoma
#13
REVIEW
Wenhui Wang, Qiuwei Pan, Gwenny M Fuhler, Ron Smits, Maikel P Peppelenbosch
Hepatitis C virus (HCV) infection is one of the leading causes of hepatocellular carcinoma (HCC) worldwide but the mechanistic basis as to how chronic HCV infection furthers the HCC process remains only poorly understood. Accumulating evidence indicates that HCV core and nonstructural proteins provoke activation of the Wnt/β-catenin signaling pathway, and the evidence supporting a role of Wnt/β-catenin signaling in the onset and progression of HCC is compelling. Convincing molecular explanations as to how expression of viral effectors translates into increased activity of the Wnt/β-catenin signaling machinery are still largely lacking, hampering the design of rational strategies aimed at preventing HCC...
December 29, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28035421/digitoxin-synergizes-with-sorafenib-to-inhibit-hepatocelluar-carcinoma-cell-growth-without-inhibiting-cell-migration
#14
Yijun Xiao, Wei Yan, Libin Guo, Chen Meng, Bin Li, Henrique Neves, Peng-Chen Chen, Ling Li, Yide Huang, Hang Fai Kwok, Yao Lin
Sorafenib is a chemotherapeutic agent approved for the treatment of hepatocellular carcinoma (HCC) in China. Digitoxin is a cardiotonic drug, which has been demonstrated to exhibit anticancer effects in a number of cancers, but not in HCC. The aim of the present study was to evaluate the combinational effect of sorafenib and digitoxin on the treatment of HCC and to investigate the relevant molecular mechanisms of action that underlie these effects. The proliferation, cell death and migration of HCC cell lines, HepG2 and BEL‑7402, were examined using MTT, acridine orange/ethidium bromide staining and scratch wound healing assays, respectively...
February 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28027570/aldehyde-dehydrogenase-2-aldh2-opposes-hcc-progression-by-regulating-ampk-signaling
#15
Guojun Hou, Lei Chen, Gang Liu, Liang Li, Yuan Yang, He-Xin Yan, Hui-Lu Zhang, Jing Tang, Ying Cheng Yang, Ximeng Lin, Xin Chen, Gui Juan Luo, Yanjing Zhu, Shanhua Tang, Jin Zhang, Hui Liu, Qingyang Gu, Ling-Hao Zhao, Yixue Li, Lei Liu, Weiping Zhou, Hongyang Wang
: Potential biomarkers that can be used to determine prognosis and perform targeted therapies are urgently needed to treat patients with hepatocellular carcinoma (HCC). To meet this need, we performed a screen to identify functional genes associated with hepatocellular carcinogenesis and its progression at the transcriptome and proteome levels. We identified Aldehyde Dedydrogenase-2 (ALDH2) as a gene of interest for further study. ALDH2 levels were significantly lower at the mRNA and protein level in tumor tissues than in normal tissues, and they were even lower in tissues that exhibited increased migratory capacity...
December 27, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28025149/substrate-stiffness-promotes-latent-tgf-%C3%AE-1-activation-in-hepatocellular-carcinoma
#16
Mingshu Pang, Yao Teng, Jianyong Huang, Yuan Yuan, Feng Lin, Chunyang Xiong
Hepatocellular carcinoma (HCC) was usually coupled with increased stiffness of the extracellular matrix (ECM) and elevated level of transforming growth factor-β1 (TGF-β1). However, the mechanism by which substrate rigidity modulated TGF-β1 signaling transduction remained unknown. This paper investigated the molecular mechanism of how matrix stiffness regulating TGF-β1 signaling in HCC cells. By means of stiffness tunable collagen I-coated polyacrylamide (PA) gels, we found that the expressions of β1 integrin, p-FAK (Y397) and p-Smad2 upregulated on stiffer gels as well as the content of TGF-β1 in culture media of HCC cells, which were inhibited by RGD blocking peptides, Y-27632 (ROCK inhibitor) or Blebbistatin (myosin II inhibitor)...
December 24, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28018100/reprogramming-of-glucose-metabolism-in-hepatocellular-carcinoma-progress-and-prospects
#17
REVIEW
Run-Ze Shang, Shi-Bin Qu, De-Sheng Wang
Hepatocellular carcinoma (HCC) is one of the most lethal cancers, and its rate of incidence is rising annually. Despite the progress in diagnosis and treatment, the overall prognoses of HCC patients remain dismal due to the difficulties in early diagnosis and the high level of tumor invasion, metastasis and recurrence. It is urgent to explore the underlying mechanism of HCC carcinogenesis and progression to find out the specific biomarkers for HCC early diagnosis and the promising target for HCC chemotherapy...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28012230/targeting-muc1-and-jnk-by-rna-interference-and-inhibitor-inhibit-the-development-of-hepatocellular-carcinoma
#18
Juan Wang, Wei-Hua Ni, Ke-Bang Hu, Xiao-Yu Zhai, Fei Xie, Jing Jie, Nan-Nan Zhang, Li-Na Jiang, Hong-Yan Yuan, Gui-Xiang Tai
Mucin 1 (MUC1), as an oncogene, is overexpressed in hepatocellular carcinoma (HCC) cells and promotes the progression and tumorigenesis of HCC through JNK/TGF-β signaling pathway. In the present study, RNA interference (RNAi) and JNK inhibitor SP600125, which target MUC1 and/or JNK, were used to treat HCC cells in vitro, and the results showed that both silencing the expression of MUC1 and blocking the activity of JNK inhibited the proliferation of HCC cells. In addition, MUC1-stable-knockdown and SP600125 significantly inhibited the growth of tumors in the subcutaneous transplant tumor models that established in BALB/c nude mice rather than MUC1 or JNK siRNAs transiently transfection...
December 23, 2016: Cancer Science
https://www.readbyqxmd.com/read/28011486/hyperforin-inhibits-cell-growth-by-inducing-intrinsic-and-extrinsic-apoptotic-pathways-in-hepatocellular-carcinoma-cells
#19
I-Tsang Chiang, Wei-Ting Chen, Chih-Wei Tseng, Yen-Chung Chen, Yu-Cheng Kuo, Bi-Jhih Chen, Mao-Chi Weng, Hwai-Jeng Lin, Wei-Shu Wang
The aim of the present study was to investigate the antitumor effect and mechanism of action of hyperforin in hepatocellular carcinoma (HCC) SK-Hep1 cells in vitro. Cells were treated with different concentrations of hyperforin for different periods of time. Effects of hyperforin on cell viability, apoptosis signaling, and expression of anti-apoptotic and proliferative proteins [cellular FLICE-like inhibitory protein (c-FLIP), X-linked inhibitor of apoptosis protein (XIAP), myeloid cell leukemia 1(MCL1), and cyclin-D1] were investigated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, flow cytometry, and western blotting...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/28007318/suberoylanilide-hydroxamic-acid-a-histone-deacetylase-inhibitor-alters-multiple-signaling-pathways-in-hepatocellular-carcinoma-cell-lines
#20
Selvi Kunnimalaiyaan, Kevin Sokolowski, T Clark Gamblin, Muthusamy Kunnimalaiyaan
INTRODUCTION: Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, has preclinical efficacy in hepatocellular carcinoma (HCC), despite an unclear molecular mechanism. We sought to further investigate the effects of SAHA on HCC. We hypothesize SAHA will inhibit HCC cellular proliferation through apoptosis and aid in further profiling SAHA's effect on HCC oncogenic pathways. METHODS: HCC cell lines were treated with various concentrations of SAHA...
December 11, 2016: American Journal of Surgery
keyword
keyword
51705
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"