keyword
MENU ▼
Read by QxMD icon Read
search

HCC signaling pathway

keyword
https://www.readbyqxmd.com/read/28718435/agrin-to-yap-in-cancer-and-neuromuscular-junctions
#1
Wen-Cheng Xiong, Lin Mei
Agrin is utilized by motor neurons to stimulate the LRP4-MuSK receptor in muscles for neuromuscular junction (NMJ) formation. Recent studies of cancer have identified novel functions of the low-density lipoprotein receptor-related protein 4-muscle-specific kinase (LRP4-MuSK) pathway. Agrin may act as a mechanotransduction signal in the extracellular matrix (ECM) to coordinate the cross-talk between the LRP4-MuSK pathway and integrin-focal adhesion pathway. Ensuing Yes-associated protein (YAP) activation promotes hepatocellular carcinoma (HCC)...
April 2017: Trends in Cancer
https://www.readbyqxmd.com/read/28714063/microrna-206-prevents-the-pathogenesis-of-hepatocellular-carcinoma-via-modulating-expression-of-cmet-and-cdk6
#2
Heng Wu, Junyan Tao, Xiaolei Li, Tianpeng Zhang, Lei Zhao, Yao Wang, Lei Zhang, Jun Xiong, Zhi Zeng, Na Zhan, Clifford J Steer, Li Che, Mingjie Dong, Xiaomei Wang, Junqi Niu, Zhuoyu Li, Guiqing Yan, Xin Chen, Guisheng Song
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide and therapeutic agents for this malignancy are lacking. MicroRNAs play critical roles in carcinogenesis and present tremendous therapeutic potential. Here we report that microRNA-206 is a robust tumor suppressor that plays important roles in the development of HCC by regulating cell cycle progression and cMet signaling pathway. MicroRNA-206 was under-expressed in livers of two HCC mouse models, human individuals bearing HCC, and human HCC cell lines...
July 17, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28713988/coronin-3-negatively-regulates-g6pc3-in-hepg2-cells-as-identified-by-label%C3%A2-free-mass%C3%A2-spectrometry
#3
Yunzhen Gao, Ling Li, Xiaohua Xing, Minjie Lin, Yongyi Zeng, Xiaolong Liu, Jingfeng Liu
Human coronin 3 is involved in many types of cancers, but the underlying molecular mechanisms require further elucidation. The present study demonstrated that coronin 3 is significantly upregulated in clinical primary hepatocellular carcinoma (HCC) samples by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and immunohistochemical staining. Subsequently, proteins that were regulated by coronin 3 in both coronin 3 overexpressing or knocked down HepG2 cells were analyzed by label free mass spectrometry; overall, 249 proteins were identified to be closely regulated by coronin 3, and those coronin 3 regulated proteins were enriched in cellular, physiological and metabolism processes...
July 15, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28710407/role-of-insulin-receptor-substrates-in-the-progression-of-hepatocellular-carcinoma
#4
Yoshitaka Sakurai, Naoto Kubota, Iseki Takamoto, Atsushi Obata, Masahiko Iwamoto, Takanori Hayashi, Masakazu Aihara, Tetsuya Kubota, Hiroshi Nishihara, Takashi Kadowaki
Several cellular signaling pathways, including insulin/IGF signaling, are known to be activated in hepatocellular carcinoma (HCC). Here, we investigated the roles of insulin receptor substrate (Irs) 1 and Irs2, both of which are the major molecules to be responsible for transducing insulin/IGF signaling in the liver, in the development of HCC by inducing chemical carcinogenesis using diethylnitrosamine (DEN) in mice. The Irs1 mRNA and protein expressions were upregulated in the tumors, along with enhanced insulin signaling...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28706416/implication-of-the-hedgehog-pathway-in-hepatocellular-carcinoma
#5
REVIEW
Carminia Maria Della Corte, Giuseppe Viscardi, Federica Papaccio, Giovanna Esposito, Giulia Martini, Davide Ciardiello, Erika Martinelli, Fortunato Ciardiello, Floriana Morgillo
The prognosis for patients who are diagnosed with advanced stage hepatocellular carcinoma (HCC) is poor because there are few treatment options. Recent research has focused on the identification of novel molecular entities that can be targeted to inhibit oncogenic signals that are involved in the carcinogenesis, proliferation and progression of HCC. Among all of the pathways that are involved in the development of HCC, Hedgehog (HH) signalling has demonstrated a substantial role in hepatocarcinogenesis and HCC progression...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28704535/interferon-related-genetic-markers-of-necroinflammatory-activity-in-chronic-hepatitis-c
#6
Rosario López-Rodríguez, Ángel Hernández-Bartolomé, María Jesús Borque, Yolanda Rodríguez-Muñoz, Samuel Martín-Vílchez, Luisa García-Buey, Leticia González-Moreno, Yolanda Real-Martínez, Paloma Muñoz de Rueda, Javier Salmerón, José Ramón Vidal-Castiñeira, Carlos López-Larrea, Luis Rodrigo, Ricardo Moreno-Otero, Paloma Sanz-Cameno
INTRODUCTION: Chronic hepatitis C (CHC) is a major cause of liver disease worldwide which often leads to progressive liver inflammation, fibrosis, cirrhosis and hepatocellular carcinoma (HCC). CHC displays heterogeneous progression depending on a broad set of factors, some of them intrinsic to each individual such as the patient's genetic profile. This study aims to evaluate the contribution of certain genetic variants of crucial interferon alpha and lambda signaling pathways to the hepatic necroinflammatory activity (NIA) grade of CHC patients...
2017: PloS One
https://www.readbyqxmd.com/read/28700704/screening-for-the-protective-effect-target-of-deproteinized-extract-of-calf-blood-and-its-mechanisms-in-mice-with-ccl4-induced-acute-liver-injury
#7
Guangyu Xu, Xiao Han, Guangxin Yuan, Liping An, Peige Du
Liver injury is a common pathological basis of various liver diseases, and long-term liver injury is often an important initiation factor leading to liver fibrosis and even liver cirrhosis and hepatocellular carcinoma (HCC). It has been reported that deproteinized extract of calf blood (DECB) can inhibit the replication of hepatitis B virus and confers a protective effect on the liver after traumatic liver injury. However, few studies on the regulatory factors and mechanisms of DECB have been reported. In this current study, an acute mouse liver injury model was established with carbon tetrachloride (CCl4)...
2017: PloS One
https://www.readbyqxmd.com/read/28698660/hydrogen-sulfide-acts-as-a-double-edged-sword-in-human-hepatocellular-carcinoma-cells-through-egfr-erk-mmp-2-and-pten-akt-signaling-pathways
#8
Dongdong Wu, Mengling Li, Wenke Tian, Shuaiwei Wang, Longzhen Cui, Hui Li, Huijuan Wang, Ailing Ji, Yanzhang Li
Hydrogen sulfide (H2S) is involved in cancer biological processes. However, there are several controversies concerning the role of H2S in cancer development and progression. In this study, we found that the growth and migration of hepatocellular carcinoma (HCC) cells were enhanced by 10-100 μM NaHS and dose-dependently inhibited by 600-1000 μM NaHS. The apoptotic levels were reduced by 25-100 μM NaHS but increased by 400-1000 μM NaHS in HCC cells. After treatment with 25-50 μM NaHS, the protein levels of p-EGFR, p-ERK, MMP-2, and p-AKT were increased, whereas the levels of PTEN and the ratio of BAX/BCL-2 were down-regulated...
July 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28698142/a-novel-oncolytic-adenovirus-targeting-wnt-signaling-effectively-inhibits-cancer-stem-like-cell-growth-via-metastasis-apoptosis-and-autophagy-in-hcc-models
#9
Jian Zhang, Weijie Lai, Qiang Li, Yang Yu, Jin Jin, Wan Guo, Xiumei Zhou, Xinyuan Liu, Yigang Wang
Cancer stem cells (CSCs), which are highly differentiated and self-renewing, play an important role in the occurrence, therapeutic resistant and metastasis of hepatacellular carcinoma (HCC). Oncolytic adenoviruses have targeted killing effect on tumor cells, and are invoked as candidate drugs for cancer treatment. We designed a dual-regulated oncolytic adenovirus Ad.wnt-E1A(△24bp)-TSLC1 that targets Wnt and Rb signaling pathways respectively, and carries the tumor suppressor gene, TSLC1. Previous studies have demonstrated that oncolytic adenovirus mediated TSLC1can target liver cancer and exhibit significant cytotoxicity...
July 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28694105/cep131-indicates-poor-prognosis-and-promotes-cell-proliferation-and-migration-in-hepatocellular-carcinoma
#10
Xu-Hui Liu, Yu-Feng Yang, Heng-Ying Fang, Xue-Hua Wang, Mei-Fang Zhang, Dan-Chun Wu
Centrosomal proteins have been implicated in the progression of human diseases. CEP131 plays important roles in centrosome duplication and genome stability, but its role in cancers remains largely unknown. Here, we showed that CEP131 expression was increased in hepatocellular carcinoma (HCC), compared to the paracarcinoma tissues, at both mRNA and protein levels. High CEP131 expression was closely associated with tumor size (P=0.020), tumor capsule (P=0.043), TNM stage (P=0.007) and tumor differentiation (P=0...
July 8, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28693200/sorafenib-induced-alteration-of-protein-glycosylation-in-hepatocellular-carcinoma-cells
#11
Tianhua Liu, Riqiang Liu, Shu Zhang, Kun Guo, Qinle Zhang, Wei Li, Yinkun Liu
Sorafenib is a multikinase inhibitor and is effective in treating hepatocellular carcinoma (HCC). However, it remains unknown whether sorafenib induces the alteration of protein glycosylation. The present study treated HCC MHCC97L and MHCC97H cells with a 50% inhibitory concentration of sorafenib. Following this treatment, alteration of protein glycosylation was detected using a lectin microarray. Compared with the controls, the binding capacity of glycoproteins extracted from sorafenib-treated HCC cells to the lectins Bauhinia purpurea lectin, Dolichos biflorus agglutinin, Euonymus europaeus lectin, Helix aspersa lectin, Helix pomatia lectin, Jacalin, Maclura pomifera lectin and Vicia villosa lectin were enhanced; while, the binding capacities to the lectins Caragana arborescens lectin, Lycopersicon esculentum lectin, Limulus polyphemus lectin, Maackia amurensis lecin I, Phaseolus vulgaris leucoagglutinin, Ricinus communis agglutinin 60, Sambucus nigra lectin and Solanum tuberosum lectin were reduced (spot intensity median/background intensity median ≥2, P<0...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28688970/secretory-stanniocalcin-1-promotes-metastasis-of-hepatocellular-carcinoma-through-activation-of-jnk-signaling-pathway
#12
Kristy Kwan-Shuen Chan, Carmen Oi-Ning Leung, Carmen Chak-Lui Wong, Daniel Wai-Hung Ho, Kenneth Siu-Ho Chok, Ching-Lung Lai, Irene Oi-Lin Ng, Regina Cheuk-Lam Lo
The hypoxic microenvironment is well-characterized in hepatocellular carcinoma (HCC). Delineation of hypoxia-responsive events is an integral part to understand the pathogenesis of HCC. We studied the functional role and clinical relevance of Stanniocalcin 1 (STC1), a hypoxia-induced molecular target, in HCC. In our clinical cohort, STC1 transcript was up-regulated in HCC tumor tissues. Moreover, STC1 protein was detected in the sera of HCC patients. A higher serum STC1 level was correlated with larger tumor size and poorer 5-year disease-free survival...
July 6, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28685286/modulation-of-wnt-signaling-pathway-by-hepatitis-b-virus
#13
REVIEW
Muhammad Daud, Muhammad Adeel Rana, Tayyab Husnain, Bushra Ijaz
Hepatitis B virus (HBV) has a global distribution and is one of the leading causes of hepatocellular carcinoma. The precise mechanism of pathogenicity of HBV-associated hepatocellular carcinoma (HCC) is not yet fully understood. Viral-related proteins are known to take control of several cellular pathways like Wnt/β-catenin, TGF-β, Raf/MAPK and ROS for the virus's own replication. This affects cellular persistence, multiplication, migration, alteration and genomic instability. The Wnt/FZD/β-catenin signaling pathway plays a significant role in the pathology and physiology of the liver and has been identified as a main factor in HCC development...
July 6, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28685231/hybrid-polymeric-protein-nano-carriers-hppnc-for-targeted-delivery-of-tgf%C3%AE-inhibitors-to-hepatocellular-carcinoma-cells
#14
Nemany A N Hanafy, Alessandra Quarta, Riccardo Di Corato, Luciana Dini, Concetta Nobile, Vittorianna Tasco, Sonia Carallo, Mariafrancesca Cascione, Andrea Malfettone, Jitka Soukupova, Rosaria Rinaldi, Isabel Fabregat, Stefano Leporatti
TGFβ1 pathway antagonists have been considered promising therapies to attenuate TGFβ downstream signals in cancer cells. Inhibiting peptides, as P-17 in this study, are bound to either TGFβ1 or its receptors, blocking signal transduction. However, for efficient use of these TGFβ1antagonist as target therapeutic tools, improvement in their delivery is required. Here, a plasmid carrying specific shDNA (SHT-DNA), small interfering RNA (siRNA), and the peptide (P-17) were loaded separately into folic acid (FA)-functionalized nano-carriers made of Bovine Serum Albumin (BSA)...
August 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28684878/hepatocyte-nuclear-factor-1beta-enhances-the-stemness-of-hepatocellular-carcinoma-cells-through-activation-of-the-notch-pathway
#15
Jing-Ni Zhu, Lu Jiang, Jing-Hua Jiang, Xue Yang, Xiao-Yong Li, Jian-Xin Zeng, Rong-Yu Shi, Yang Shi, Xiao-Rong Pan, Zhi-Peng Han, Li-Xin Wei
Hepatocyte nuclear factor-1beta plays an important role in the development and progression of liver cancer. In recent years, the expression of HNF-1β has been reported to be associated with risk for a variety of cancers. The purpose of this study is to investigate whether the expression of HNF-1β promotes the malignancy of HCC and its mechanism. We retrospectively investigated the expression of HNF-1β in 90 patients with hepatocellular carcinoma and found that the high expression of HNF-1β indicated poor prognosis...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28684299/cyperus-amuricus-induces-g1-arrest-and-apoptosis-through-endoplasmic-reticulum-stress-and-mitochondrial-signaling-in-human-hepatocellular-carcinoma-hep3b-cells
#16
Hai Ha Thi Pham, Yeong-Ae Seong, Daniel Ngabire, Chul-Woong Oh, Gun-Do Kim
ETHNOPHARMACOLOGY RELEVANCE: Cyperus amuricus (C. amuricus), belongs to the family Cyperaceae, was used to exert wound healing, diuretic, astringent and other intestinal problems in oriental medicine. However, only a few studies have reported its anticancer activities. AIM OF THE STUDY: In this study, we determined the activity of C. amuricus on ER stress-induced cell death and G1 cell cycle arrest in human hepatocellular carcinoma (HCC) Hep3B cells. MATERIALS AND METHODS: The in vitro cell proliferation assay of C...
July 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28682433/mir-130b-functions-as-a-tumor-promoter-in-glioma-via-regulation-of-erk-mapk-pathway
#17
B Li, Y-H Liu, A-G Sun, L-C Huan, H-D Li, D-M Liu
OBJECTIVE: To investigate the miR-130b expression in patients with glioma and to analyze its role and underlying molecular mechanism on the carcinogenesis. PATIENTS AND METHODS: The expression levels of miR-130b were detected with quantitative Real-time PCR. The relationship between miR-130b expression and clinicopathologic characteristics were analyzed. MiR-130b inhibitor was transfected into glioma cell lines to investigate its role in HCC. MTT assays were conducted to explore the impact of miR-130b down-expression on the proliferation of human glioma cells...
June 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28680363/induction-of-apoptosis-and-proliferation-inhibition-of-hepatocellular-carcinoma-by-6-chloro-2-methoxy-n-phenylmethyl-9-acridinamine-ba-in-vitro-and-vivo-studies
#18
Yun Huang, Guohua Liu, Feng Yang, Xiaowei Xing, Ying Li, Zhijun Huang, Hong Yuan
BACKGROUND: 6-Chloro-2-methoxy-N-(phenylmethyl)-9-acridinamine (BA), a novel sponge-derived compound, has been reported to elicit a cytotoxic effect by inhibiting cell proliferation. METHODS: In this study, we investigated the anti-tumor effect of BA in human hepatocellular carcinoma (HCC) in vitro and in vivo using SMMC-7721 cells. The impact of BA on SMMC-7721 cells was determined by proliferation (clonogenicity and MTT), apoptosis (flow cytometry with annexin V-FITC labeling) and tumor cell migration (Transwell)...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28677802/norcantharidin-inhibits-il-6-induced-epithelial%C3%A2-mesenchymal-transition-via-the-jak2-stat3-twist-signaling-pathway-in-hepatocellular-carcinoma-cells
#19
Yebo Gao, Weidong Li, Rui Liu, Qiujun Guo, Jie Li, Yanju Bao, Honggang Zheng, Shulong Jiang, Baojin Hua
Epithelial-mesenchymal transition (EMT), plays a vital role in hepatocellular carcinoma (HCC) development and metastasis. Norcantharidin (NCTD; 7-oxabicyclo (2.2.1) heptane-2,3-dicarboxylic anhydride) plays anticancer roles in the regulation of tumor cell proliferation, apoptosis and migration. However, the molecular mechanism of HCC EMT and the effects of NCTD in the HCC EMT process have been either poorly elucidated or not studied. In this study, HCC EMT was induced by the treatment of IL-6 and various concentrations of NCTD (0, 30, 60 and 120 µM) were treated with HCC cell lines, HCCLM3 and SMMC-7721...
June 30, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28677801/modulation-of-igf2bp1-by-long-non-coding-rna-hcg11-suppresses-apoptosis-of-hepatocellular-carcinoma-cells-via-mapk-signaling-transduction
#20
Yantian Xu, Yuanwen Zheng, Hongyan Liu, Tao Li
Hepatocellular carcinoma (HCC) is a common malignancy of the liver. HCG11 is a member of long non‑coding family, upregulation of which in HCC was proved by our previous study. In the present study, the role of HCG11 in the development of HCC was detected by focusing on the interaction between HCG11 and its target protein insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1). The expression status of HCG11 and IGF2BP1 was first investigated with clinical HCC samples. Then the expressions of HCG11 and IGF2BP1 were both inhibited in the human HCC cell line HepG2 and the cell viability, proliferation, apoptosis and metastasis potential of HepG2 cells were assessed...
July 5, 2017: International Journal of Oncology
keyword
keyword
51705
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"