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https://www.readbyqxmd.com/read/29920416/aging-related-compensated-hypogonadism-role-of-metabolomic-analysis-in-physiopathological-and-therapeutic-evaluation
#1
Gustavo Monnerat, Fernando A C Seara, Joseph Albert Medeiros Evaristo, Gabriel Carneiro, Geisa Paulino Caprini Evaristo, Gilberto Domont, Jose Hamilton Matheus Nascimento, Jose Geraldo Mill, Fabio Cesar Souza Nogueira, Antonio Carlos Campos de Carvalho
Aging is a complex process that increases the risk of chronic disease development. Hormonal and metabolic alterations occur with aging, such as androgen activity decrease. Studies aim to understand the role of testosterone replacement therapy (TRT) in males, however biomarkers and the metabolic responses to TRT are not well characterized. Therefore, the present study investigated TRT effect in young adult and aged rats by metabolomics. Male Wistar rats were divided into four groups: adult and adult + testo (6months), old and old + testo (25-27months)...
June 16, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29912292/oestrogen-fuels-the-growth-of-endometrial-hyperplastic-lesions-initiated-by-overactive-wnt-%C3%AE-catenin-signalling
#2
Jyoti Goad, Yi-An Ko, Manish Kumar, M Fairuz B Jamaluddin, Pradeep S Tanwar
Unopposed oestrogen results in approximately 80% of all the endometrial cancer patients. The relationship between unopposed oestrogen and endometrial cancer was indicated by the increase in the number of endometrial cancer cases due to the widespread use of oestrogen replacement therapy. Approximately 30% of the endometrial cancer patients have mutations in the Wnt signalling pathway. How the unbalanced ratios of ovarian hormones and the mutations in Wnt signalling pathway interact to cause endometrial cancer is currently unclear...
June 15, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29910227/postoperative-growth-hormone-dynamics-in-clinically-nonfunctioning-pituitary-adenoma
#3
Nobuyuki Kobayashi, Mitsuo Yamaguchi-Okada, Kentaro Horiguchi, Noriaki Fukuhara, Hiroshi Nishioka, Shozo Yamada
Growth hormone deficiency (GHD) is an endocrine disorder characterized by insufficient production of growth hormone (GH). Non-functioning pituitary adenoma (NFPA) is one of common causes of GHD. Although most patients with NFPA have transsphenoidal surgery, the time-dependent changes in GH after operation have yet to be investigated. In this study, we analyzed patients with NFPAs that underwent transsphenoidal surgery. Postoperatively, GH secretion was evaluated in response to GH-releasing peptide-2 (GHRP2) infusion...
June 15, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29910217/hormone-replacement-therapy-for-hepatopulmonary-syndrome-and-nash-associated-with-hypopituitarism
#4
Nobuyuki Torii, Atsuhiro Ichihara, Yuki Mizuguchi, Yasufumi Seki, Etsuko Hashimoto, Katsutoshi Tokushige
The patient was a 23-year-old man who was diagnosed with severe hypoxemia and liver dysfunction after suffering from sudden difficulty breathing. At 2 years of age, he had been diagnosed with hypopituitarism, and had received hormone-replacement until he was 18 years of age. Echocardiography using micro bubbles and pulmonary scintigraphy indicated intrapulmonary shunt and a liver biopsy showed steatohepatitis. He was diagnosed with hepatopulmonary syndrome associated with nonalcoholic steatohepatitis. Hormone-replacement therapy was re-started...
2018: Internal Medicine
https://www.readbyqxmd.com/read/29910183/rhabdomyolysis-in-a-patient-complicated-with-hypopituitarism-and-multiple-organ-dysfunction-syndrome-and-the-literature-review
#5
Chuan Zhou, Shichao Lai, Yong Xie, Shu Zhang, Yiping Lu
INTRODUCTION: Muscular symptoms, including stiffness, myalgia, cramps, and fatigue, are present in the majority of the patients with hypopituitarism, adrenal insufficiency and hypothyroidism, but rhabdomyolysis, the rapid breakdown of skeletal muscle, is a rare manifestation. In most patients who develop rhabdomyolysis, precipitating factors, such as strenuous exercise or use of lipid-lowering drugs, can be identified. CASE REPORT: We report the case of a 23-year-old male with primary hypopituitarism who developed acute renal impairment (AKI) with rhabdomyolysis after strenuous physical activity (push-ups)...
June 7, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29907248/micro-rna-181a-suppresses-progestin-promoted-breast-cancer-cell-growth
#6
Muqing Gu, Lijuan Wang, Chun Yang, Xue Li, Chanwei Jia, Stephane Croteau, Xiangyan Ruan, Pierre Hardy
BACKGROUND: Recent investigations have indicated that hormone therapy may increase the risk of breast cancer (BC), and the addition of synthetic progestins may play a critical role in this. Several studies have pointed out the important role of progesterone receptor membrane component 1 (PGRMC1) in the development of BC, especially with hormone therapy using progestins. Although the deregulation of microRNA-181a (miR-181a) is often associated with human BC, the effect of miR-181a on PGRMC1 expression during hormone therapy has not been investigated...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29904910/is-the-secret-for-a-successful-aging-to-keep-track-of-cancer-pathways
#7
REVIEW
Donatella Tramontano, Francesca De Amicis
A successful aging could be gained by life satisfaction, social functioning, or psychological resources and, definitely, by increasing resistance to diverse age-related pathologies. Nowadays, cancer can be considered an age-related disease since the incidence of most cancers increases with age, rising more rapidly beginning in midlife. Although adults with extended longevity are less likely to develop cancer, it is now emerging that aging and cancer share common molecular links, and thus targeting these mechanisms may be suitable to treat multiple disorders, for the prolonging of healthy aging...
June 15, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29904828/estrogen-migraine-and-vascular-risk
#8
Gianni Allais, Giulia Chiarle, Silvia Sinigaglia, Gisella Airola, Paola Schiapparelli, Chiara Benedetto
Migraine has a predilection for female sex and the course of symptoms is influenced by life stage (presence of menstrual cycle, pregnancy, puerperium, menopause) and use of hormone therapy, such as hormonal contraception and hormone replacement therapy. Hormonal changes figure among common migraine triggers, especially sudden estrogen drop. Moreover, estrogens can modulate neuronal excitability, through serotonin, norepinephrine, dopamine, and endorphin regulation, and they interact with the vascular endothelium of the brain...
June 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29901576/anterior-interhemispheric-approach-for-removing-large-sellar-region-tumor
#9
Shi-Yu Feng, Tao Zhou, Zheng-Hui Sun, Bo Bu, Jin-Li Jiang
The aim of the study was to explore anterior interhemispheric approach microsurgery for removing large sellar region tumors.A total of 118 patients with large sellar region tumors were treated with the anterior interhemispheric approach microsurgery. There were 58 craniopharyngioma, 37 pituitary adenoma, 5 hypothalamic glioma, 7 meningioma, and 11 other tumors cases. The maximal tumor diameter ranged from 3.0 to 8.2 cm, with a mean diameter of 4.3 cm. Diabetes insipidus and fluid and electrolyte imbalance were timely controlled after surgery...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29897458/increased-aif-1-mediated-tnf-%C3%AE-expression-during-implantation-phase-in-ivf-cycles-with-gnrh-antagonist-protocol
#10
Bufang Xu, Mingjuan Zhou, Jingwen Wang, Dan Zhang, Feng Guo, Chenchen Si, Peter C K Leung, Aijun Zhang
STUDY QUESTION: Is allograft inflammatory factor-1 (AIF-1), a cytokine associated with inflammation and allograft rejection, aberrantly elevated in in vitro fertilization (IVF) cycles with gonadotropin-releasing hormone (GnRH) antagonist protocol with potential effects on endometrial receptivity? SUMMARY ANSWER: Our findings indicated AIF-1 is increased in IVF cycles with GnRH antagonist protocol and mediates greater TNF-α expression during implantation phase, which may be unfavorable for embryo implantation...
June 12, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29895525/the-hypothalamic-pituitary-adrenal-axis-in-childhood-cancer-survivors
#11
Christina Wei, Elizabeth Crowne
Endocrine abnormalities are common among childhood cancer survivors. Abnormalities of the hypothalamic-pituitary-adrenal axis (HPAA) are the least common, but the consequences are severe if missed. Patients with tumours located and /or had surgery performed near the hypothalamic-pituitary region and those treated with an accumulative cranial radiotherapy dose of over 30 Gy are most at risk of adrenocorticotrophic hormone (ACTH) deficiency. Primary adrenal insufficiency may occur in patients with tumours located in or involving one or both adrenals...
June 12, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29895017/transition-in-pediatric-and-adolescent-hypogonadal-girls-gynecological-aspects-estrogen-replacement-therapy-and-contraception
#12
Anette Tønnes Pedersen, Line Cleemann, Katharina M Main, Anders Juul
Hypogonadism may be suspected if puberty is delayed. Pubertal delay may be caused by a normal physiological variant, by primary ovarian insufficiency (Turner syndrome), or reflect congenital hypogonadotropic hypogonadism (HH; genetic) or acquired HH (brain lesions). Any underlying chronic disease like inflammatory bowel disease, celiac disease, malnutrition (anorexia or orthorexia), or excessive physical activity may also result in functional HH. Thus, girls with delayed puberty should be evaluated for an underlying pathology before any treatment, including oral contraception, is initiated...
2018: Endocrine Development
https://www.readbyqxmd.com/read/29894991/metabolic-complications-in-adrenal-insufficiency
#13
Grethe A Ueland, Eystein S Husebye
Pharmacological glucocorticoid treatment is associated with adverse metabolic consequences such as hypertension, overweight, reduced glucose tolerance, diabetes mellitus and ultimately increased mortality in cardiovascular disease. Here we review the evidence of detrimental effects of hormone replacement therapy in adrenal insufficiency (AI). Registry studies indicate increased cardiovascular mortality, hypertension, diabetes, and dyslipidemia in both primary and secondary AI, but when cohorts with carefully characterized patients are studied the picture is less clear, and recently patients with primary AI was reported to have less hypertension and lower body mass index than controls...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29891459/-effect-of-serum-estradiol-level-before-progesterone-administration-on-pregnancy-outcomes-of-frozen-thawed-embryo-transfer-cycles
#14
Ling Deng, Xin Chen, De-Sheng Ye, Shi-Ling Chen
OBJECTIVE: To explore whether a high serum estradiol (E2) level before progesterone administration adversely affects the pregnancy outcomes of frozen-thawed embryo transfer (FET) cycles. METHODS: We retrospectively analyzed 205 hormone replacement therapy (HRT)-FET cycles in our Center between February, 2017 and August, 2017. With a cutoff value of serum E2 level of 600 pg/mL before progesterone administration, the cases were divided into high E2 level group and control group with normal E2 level, and the clinical characteristics and pregnancy outcomes were compared between the two groups...
May 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29886502/management-of-hypothalamic-obesity-during-transition-from-childhood-to-adulthood
#15
Marion Bretault, Claire Carette, Charles Barsamian, Sébastien Czernichow
Hypothalamic obesity (HO) is a rare and serious disease of various origins: tumor, traumatism, radiotherapy, vascular, genetic, or even psychotropic drug use. HO usually begins in childhood with eating disorders and progresses with an aggregate of severe comorbidities. Transition from pediatric to adult health care is a critical period to assure weight stability and a good management of comorbidities. In case of loss to follow-up, there is an increased risk of major weight gain and long-term complications with severe obesity...
2018: Endocrine Development
https://www.readbyqxmd.com/read/29886487/transition-of-care-from-childhood-to-adulthood-congenital-adrenal-hyperplasia
#16
Anne Bachelot
Deficiency of the 21-hydroxylase enzyme is the most common form of congenital adrenal hyperplasia (CAH), accounting for more than 95% of the cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into adulthood. Adolescents and adults with CAH experience a number of complications, including short stature, obesity, infertility, impaired bone mineral density, and reduced quality of life. Transition from pediatric to adult care and management of long-term complications are challenging for both patients and practitioners...
2018: Endocrine Development
https://www.readbyqxmd.com/read/29886481/growth-hormone-deficiency-in-the-transition-age
#17
Sandro Loche, Natascia Di Iorgi, Giuseppa Patti, Serena Noli, Marta Giaccardi, Irene Olivieri, Anastasia Ibba, Mohamad Maghnie
Growth hormone (GH) is essential not only for normal growth during childhood, but also for the acquisition of bone mass and muscle strength in both sexes. This process is completed after the achievement of adult height in the phase of transition from adolescence to adulthood. Adolescents with childhood onset GH deficiency (GHD) show reduction of bone mineral density, decrease in lean body mass, increase in fat mass, and deterioration of the lipid profile. For this reason, continuation of GH replacement therapy in the transition age is recommended in all patients with a confirmed diagnosis of GHD...
2018: Endocrine Development
https://www.readbyqxmd.com/read/29880706/management-of-endocrine-disease-hypophysitis-diagnosis-and-treatment
#18
Mamta N Joshi, Benjamin Whitelaw, Paul V Carroll
Hypophysitis is a rare condition characterised by inflammation of the pituitary gland, usually resulting in hypopituitarism and pituitary enlargement. Pituitary inflammation can occur as a primary hypophysitis (most commonly lymphocytic, granulomatous or xanthomatous disease) or as secondary hypophysitis (as a result of systemic diseases, immunotherapy or alternative sella based pathologies). Hypophysitis can be classified using anatomical, histopathological and aetiological criteria. Non-invasive diagnosis of hypophysitis remains elusive, and the use of currently available serum anti-pituitary antibodies are limited by low sensitivity and specificity...
June 7, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/29878886/establishing-a-rationale-for-compounding-hormone-replacement-therapy
#19
Bruce Biundo
Why compound bioidentical hormones? Are there no similar commercial products? What is unique about the options compounding pharmacists offer compared with what is out in the marketplace? These are questions that physicians and other practitioners are asking, and it is very important that we have intelligent, well-thought answers when we respond. Times have changed, and the challenges we face today in marketing our compounded therapies are not the same as those of twenty years ago. Premarin is no longer at the top of the heap, and there are topical, commercial products that contain bioidentical estradiol, and capsules that contain the same progesterone that we use...
May 2018: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/29876983/phytoestrogens-the-current-state-of-research-emphasizing-breast-pathophysiology
#20
REVIEW
Harini Anandhi Senthilkumar, Jimmie E Fata, Edward J Kennelly
Phytoestrogens, a class of plant-derived compounds that are structural mimics of estrogen, can bind to estrogen receptors, acting as either agonists or antagonists. They have been implicated in estrogen-mediated physiology, which makes them interesting targets of study, especially for biomedical applications in woman's health. The 1998 Women's Health Initiative sparked considerable interest in natural alternatives to hormone replacement therapy, thereby triggering many additional studies on phytoestrogens. In this review, key advancements in dietary phytoestrogens are addressed, emphasizing their relation to breast pathophysiology...
June 7, 2018: Phytotherapy Research: PTR
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