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Hormone replacement therapy

Anika Westphal, Ralf Mrowka
Hormones: They control the human circadian rhythm, cause happiness after physical exercise, cause butterflies in one's stomach and contribute to the chemistry of love, turn a pregnant woman's life upside down and influence the growth of the fetus, in short, they are essential in the human individual development and homeostasis of organs. Hormones are mainly produced in the brain, pancreas, thyroid, kidney and the genital organs and represent the most important chemical messengers in the human organism. Hormone-dependent pathologic conditions are manifold and dysregulations need to be treated in order to warrant a healthy human body...
September 21, 2018: Acta Physiologica
Dong Won Byun, Seong-Hwan Moon, Tak Kim, Hae-Hyeog Lee, Hyoung Moo Park, Moo-Il Kang, Yong-Chan Ha, Ho-Yeon Chung, Byung-Koo Yoon, Tae-Young Kim, Soo Uk Chae, Chan Soo Shin, Kyu-Hyun Yang, Jae Hyup Lee, Jae Suk Chang, Sung Hoon Kim, In Joo Kim, Jung-Min Koh, Jung Hwa Jung, Kyong Wook Yi, Jeong Joon Yoo, Dong Jin Chung, Young-Kyun Lee, Hyun-Koo Yoon, Seongbin Hong, Deog-Yoon Kim, Ki Hyun Baek, Hyun-Joo Kim, Young-Joo Kim, Seongsik Kang, Yong-Ki Min
Patient-reported outcomes (PROs) provide practical guides for treatment; however, studies that have evaluated PROs of women in Korea with postmenopausal osteoporosis (PMO) are lacking. This cross-sectional, multi-center (29 nationwide hospitals) study, performed from March 2013 to July 2014, aimed to assess PROs related to treatment satisfaction, medication adherence, and quality of life (QoL) in Korean PMO women using osteoporosis medication for prevention/treatment. Patient demographics, clinical characteristics, treatment patterns, PROs, and experience using medication were collected...
September 20, 2018: Journal of Bone and Mineral Metabolism
Linxin Xu, Yi Ren, Jianhong Yin, Jing Yang, Yunfeng Liu, Jin Zhang, Yi Zhang, Chenyu Xiang, Luyang Yang
RATIONALE: Mucopolysaccharidosis IVA (Morquio A) is a catabolic mucopolysaccharide disorder caused by galactose-6-sulfate sulfatase deficiency. It is an autosomal recessive inherited disease. Previous reports on clinical characteristics of Morquio A mainly focused on growth retardation, skeletal deformities, and organ damage in children and adolescents, while the effects of mucopolysaccharide metabolism disorders on endocrine hormone metabolism level have not been reported. Herein, we reported the endocrine hormone metabolism in a case diagnosed as Morquio A...
September 2018: Medicine (Baltimore)
B Nagaraju Naik, Ashish Bhalla, Navneet Sharma, Jitender Mokta, Surjit Singh, Prakamya Gupta, Ashutosh Rai, Sridhar Subbiah, Anil Bhansali, Pinaki Dutta
Purpose: Endocrinal insufficiency caused by vasculotoxic snake envenomation is under-recognized and is mostly confined to a specific geographic area. We conducted a prospective study to determine the prevalence and pattern of pituitary-target gland insufficiencies caused by snake envenomation. Materials and Methods: The hormonal evaluation of patients who had suffered from vasculotoxic snake envenomation was done at baseline and at 6 months of follow-up. Those patients with a documented hormonal insufficiency underwent magnetic resonance imaging (MRI) of the hypothalamo-pituitary area...
September 2018: Neurology India
Tsubasa Aiyoshi, Toshihiro Muraji, Isho Izumi, Miki Toma, Kazuto Suda, Toshihiro Yanai, Kouji Masumoto
BACKGROUND: Currently, there is no consensus regarding the optimal therapeutic strategy for the management of an ectopic lingual thyroid. A surgical approach is suggested when airway obstructive symptoms cannot be tolerated at all, or when bleeding or malignancy occurs. However, for patients in whom ectopic thyroid is the only functioning thyroid tissue, complete surgical excision needs to be followed by lifelong hormone replacement therapy. We report the case of an infant with ectopic lingual thyroid obstructing the airway that was treated using our novel surgical procedure...
September 19, 2018: Surgical Case Reports
Hugh-Owen Colhoun, Estela M Rubio Gozalbo, Annet M Bosch, Ina Knerr, Charlotte Dawson, Jennifer Brady, Marie Galligan, Karolina Stepien, Roisin O'Flaherty, C Catherine Moss, P Peter Barker, Maria Fitzgibbon, Peter P Doran, Eileen P Treacy
BACKGROUND: Classical Galactosaemia (CG) (OMIM #230400) is a rare inborn error of galactose metabolism caused by deficiency of the enzyme galactose-1-phosphate uridylyltransferase (GALT). Long-term complications persist in treated patients despite dietary galactose restriction with significant variations in outcomes suggesting epigenetic glycosylation influences. Primary Ovarian Insufficiency (POI) is a very significant complication affecting females with follicular depletion noted in early life...
September 19, 2018: Orphanet Journal of Rare Diseases
R S Du Puy, I Postmus, D J Stott, M R Blum, R K E Poortvliet, W P J Den Elzen, R P Peeters, B C van Munster, B H R Wolffenbuttel, R G J Westendorp, P M Kearney, I Ford, S Kean, C M Messow, T Watt, J W Jukema, O M Dekkers, J W A Smit, N Rodondi, J Gussekloo, S P Mooijaart
BACKGROUND: Subclinical hypothyroidism is common in older people and its contribution to health and disease needs to be elucidated further. Observational and clinical trial data on the clinical effects of subclinical hypothyroidism in persons aged 80 years and over is inconclusive, with some studies suggesting harm and some suggesting benefits, translating into equipoise whether levothyroxine therapy provides clinical benefits. This manuscript describes the study protocol for the Institute for Evidence-Based Medicine in Old Age (IEMO) 80-plus thyroid trial to generate the necessary evidence base...
September 19, 2018: BMC Endocrine Disorders
Michael Zitzmann
Testosterone is a natural hormone which is essential to maintain physical and emotional wellbeing in men. Male hypogonadism is an endocrine condition of testosterone deficiency with the potential to cause multiple morbidities and psychosocial complaints. The condition can be of primary (testicular), secondary (hypothalamic-pituitary) or so-called functional origin (as a result of inflammatory conditions, obesity or chronic illness). Testosterone deficiency can cause symptoms of sexual nature, insulin resistance, osteoporosis, anemia among others...
September 2018: Deutsche Medizinische Wochenschrift
Aravinth P Jawahar, Siddharth Narayanan, Gopalakrishnan Loganathan, Jithu Pradeep, Gary C Vitale, Michael G Hughes, Stuart K Williams, Appakalai N Balamurugan
Islet cell auto-transplantation is a novel strategy for maintaining blood glucose levels and improving the quality of life in patients with chronic pancreatitis (CP). Despite the many recent advances associated with this therapy, obtaining a good yield of islet infusate still remains a pressing challenge. Reprogramming technology, by making use of the pancreatic exocrine compartment, can open the possibility of generating novel insulin-producing cells. Several lineage-tracing studies present evidence that exocrine cells undergo dedifferentiation into a progenitor-like state from which they can be manipulated to form insulin-producing cells...
September 17, 2018: Current Stem Cell Research & Therapy
Hassan Dehaini, Manal Fardoun, Haissam Abou Saleh, Ahmed El-Yazbi, Assaad A Eid, Ali H Eid
Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. The effect of estrogen on these diseases has been assessed in in vitro and in vivo models, as well as in observational studies. Collectively, these studies alluded to a cardiovasculo-protective effect of estrogen. However, comprehensive clinical investigation failed to produce concrete proof of a cardiovascular protective effect for hormone replacement therapy (HRT), let alone rule out potential harm. These seemingly paradoxical effects of estrogen were explained by the 'theory of timing and opportunity'...
September 15, 2018: Vascular Pharmacology
Ellen J Hoekman, Dan Knoester, Alexander A W Peters, Frank W Jansen, Cornelis D de Kroon, Carina G J M Hilders
PURPOSE: To evaluate the effectiveness of ovarian transposition (OT) prior to radiation therapy (RT) and to evaluate the effect of age on ovarian survival (OS) after OT. METHODS: We performed a retrospective control study, with women (aged < 45 years) who underwent OT prior to pelvic radiation, versus women diagnosed with cervical cancer and treated with hysterectomy/trachelectomy and radiation therapy. All women were treated between 1989 and 2010. The 5 years OS rate was calculated, with a sub-analysis for age (25-30; 31-35 and 36-40 years)...
September 14, 2018: Archives of Gynecology and Obstetrics
İsmail Zihni, Volkan Soysal, Adam Uslu, Baha Zengel, Gökalp Okut, Ahmet Aykas, Ali Duran, Erhan Tatar
OBJECTIVES: The literature about the frequency of metabolic syndrome in patients with multinodular goitre and a new onset of metabolic syndrome after total thyroidectomy is limited. The aim of this study was to investigate the effects of total thyroidectomy and thyroid hormones on a new onset of metabolic syndrome in patients who underwent total thyroidectomy and have received thyroid hormone replacement. MATERIAL AND METHODS: Fifty-nine patients who underwent total thyroidectomy for multinodular goitre were included in this prospective study...
August 28, 2018: Turkish Journal of Surgery
Robert C Speth, Mikayla D'Ambra, Hong Ji, Kathryn Sandberg
The issue of cardiovascular and cognitive health in women is complex. During the premenopausal phase of life women have healthy blood pressure (BP) levels that are lower than age-matched men and they have less cardiovascular disease. However, in the post-menopausal stage of life women's BP increases and they are increasingly susceptible to cardiovascular disease, cognitive impairments and dementia, exceeding the incidence in men. The major difference between pre- and post-menopausal women is the loss of estrogen...
September 14, 2018: American Journal of Physiology. Heart and Circulatory Physiology
André Tchernof, Dannick Brochu, Ina Maltais-Payette, Mohamed Fouad Mansour, Geneviève B Marchand, Anne-Marie Carreau, Jordanna Kapeluto
The sexual dimorphism in human body fat distribution suggests a causal role for sex hormones. This is of particular importance when considering the role of excess visceral adipose tissue accumulation as a critical determinant of obesity-related cardiometabolic alterations. Scientific literature on the modulation of body fat distribution by androgens in humans is abundant, remarkably inconsistent and difficult to summarize. We reviewed relevant literature on this topic, with a particular emphasis on androgen replacement, androgen effects on selected parameters of adipose tissue function and adipose tissue steroid-converting enzymes...
September 14, 2018: Comprehensive Physiology
Xin Lian, Xiaorong Hou, Junfang Yan, Shuai Sun, Zheng Miao, Zhikai Liu, Weiping Wang, Jing Shen, Jie Shen, Ke Hu, Fuquan Zhang
PURPOSE: To perform a retrospective analysis of patients with intracranial germinoma treated in our department to evaluate treatment outcomes and determine optimal treatment strategies. METHODS: We reviewed the treatment outcomes of 170 patients with intracranial germinoma who were treated in our department from January 1996 to January 2017. The median patient age was 15 years old. Among the patients, 56 (33%) were pathologically diagnosed, and 114 (67%) were diagnosed clinically...
September 12, 2018: Journal of Cancer Research and Clinical Oncology
Adel A Hagag, Hassan M El-Asy, Ibrahim M Badraia, Nahed M Hablas, Amal Ezzat Abd El-Latif
BACKGROUND: 'Sickle cell disease (SCD) is characterized by defective hemoglobin synthesis, hemolytic anemia, frequent thrombosis and chronic organ damage including endocrine organs'. AIM OF THE WORK: to assess thyroid function in children with SCD in correlation with iron load. PATIENTS AND METHODS: This study was conducted on 40 children with SCD with iron overload (serum ferritin more than 1000 ng/ml) including 22 males and 18 females with their ages ranging from 11-14 years and mean age value of 11...
September 12, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Evangelia Mareti, Christina Ampatzi, Stavroula A Paschou, Evangelia Voziki, Dimitrios G Goulis
INTRODUCTION: Menopause is associated with adverse effects on quality of life of peri-menopausal and post-menopausal women. It also has an impact on the development of cardiovascular disease (CVD). Hormonal treatments are the most effective medications for menopausal symptoms relief. Given the fact that hormonal treatments are contraindicated for many women, non-hormonal treatment, such as Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs), gabapentin, pregabalin, clonidine and phytoestrogens, constitute alternative treatments...
September 10, 2018: Current Vascular Pharmacology
Sitraka Angelo Raharinavalona, Iandry Michella Razafinjatovo, Rija Eric Raherison, Thierry Razanamparany, Andriamparany Rasata Ravelo, Andrinirina Dave Patrick Rakotomalala
Thyroid ectopia is rare. It results from a failure of migration of the thyroid gland during its embryonic development. It is most often asymptomatic. We here report a case of thyroid ectopia in the hyoid region in a young Malagasy girl, presenting as aesthetic discomfort associated with subclinical hypothyroidism. Diagnosis was confirmed using cervical ultrasound and scintigraphy with technetium-99m. Hormone replacement therapy is the gold standard even in patients with subclinical hypothyroidism because it results in physiologic euthyroidism and good clinical evolution...
2018: Pan African Medical Journal
Naouel Tifaoui, Thierry Maudelonde, Jacques Combecal, Roselyne Vallo, Sylviane Doutre, Marie-Noëlle Didelot, Nicolas Nagot, Michel Segondy, Nathalie Boulle
BACKGROUND: With population ageing, post-menopausal women represent a new group to be considered in cervical cancer screening strategies, including the significance of High Risk (HR)-HPV detection. OBJECTIVES: A retrospective analysis was conducted in a cohort of 406 menopausal women attending routine gynaecological consultation at the Hospital of Montpellier (France). STUDY DESIGN: All women benefited from a cervical smear and HR-HPV detection using Hybrid Capture 2 (HC2) test...
August 31, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Johanna Marie Richey, Miranda Lucia Ritterman Weintraub, John M Schuberth
BACKGROUND: The incidence rate of venous thrombotic events (VTEs) following foot and ankle surgery is low. Currently, there is no consensus regarding postoperative prophylaxis or evidence to support risk stratification. METHODS: A 2-part study assessing the incidence and factors for the development of VTE was conducted: (1) a retrospective observational cohort study of 22 486 adults to calculate the overall incidence following foot and/or ankle surgery from January 2008 to May 2011 and (2) a retrospective matched case-control study to identify risk factors for development of VTE postsurgery...
September 7, 2018: Foot & Ankle International
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