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https://www.readbyqxmd.com/read/29053449/thermo-acoustic-ultrasound-for-detection-of-rf-induced-device-lead-heating-in-mri
#1
Neerav Dixit, Pascal P Stang, John M Pauly, Greig C Scott
Patients who have implanted medical devices with long conductive leads are often restricted from receiving MRI scans due to the danger of RF-induced heating near the lead tips. Phantom studies have shown that this heating varies significantly on a case-by-case basis, indicating that many patients with implanted devices can receive clinically useful MRI scans without harm. However, the difficulty of predicting RF-induced lead tip heating prior to scanning prevents numerous implant recipients from being scanned...
October 17, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29051964/identification-of-quality-improvement-areas-in-pediatric-mri-from-analysis-of-patient-safety-reports
#2
Camilo Jaimes, Diana J Murcia, Karen Miguel, Cathryn DeFuria, Pallavi Sagar, Michael S Gee
BACKGROUND: Analysis of safety reports has been utilized to guide practice improvement efforts in adult magnetic resonance imaging (MRI). Data specific to pediatric MRI could help target areas of improvement in this population. OBJECTIVE: To estimate the incidence of safety reports in pediatric MRI and to determine associated risk factors. MATERIALS AND METHODS: In a retrospective HIPAA-compliant, institutional review board-approved study, a single-institution Radiology Information System was queried to identify MRI studies performed in pediatric patients (0-18 years old) from 1/1/2010 to 12/31/2015...
October 19, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/29045806/safety-of-magnetic-resonance-imaging-in-patients-with-legacy-pacemakers-and-defibrillators-and-abandoned-leads
#3
Deepak Padmanabhan, Danesh K Kella, Ramila Mehta, Suraj Kapa, Deshmukh Abhishek, Siva Mulpuru, Allan S Jaffe, Joel P Felmlee, Mary L Jondal, Connie M Dalzell, Samuel J Asirvatham, Yong-Mei Cha, Robert E Watson, Paul A Friedman
BACKGROUND: During magnetic resonance imaging (MRI), abandoned leads may act as antennae that result in tissue heating and arrhythmia induction. OBJECTIVES: To assess the safety of MRI in patients with abandoned leads, with the addition of cardiac troponin T (CTnT) assessment to screen for myocardial damage. METHODS: We reviewed our prospectively collected database of patients with CIEDs undergoing MRI between 2008-2017 at Mayo Clinic, Rochester, Minnesota and selected patients who had abandoned leads...
October 15, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29037373/fast-inverse-prediction-of-the-freezing-front-in-cryosurgery
#4
REVIEW
Mohamed Hafid, Marcel Lacroix
Cryosurgery has become a well-established technique for the ablation of undesirable tissues such as tumors and cancers. The motivation for this study is to improve the efficacy and safety of this technique. This study presents an inverse heat transfer method for monitoring the motion of the freezing front from a cryoprobe. With the help of a thermocouple inserted into the layer of diseased tissue, the inverse heat transfer method estimates simultaneously the blood perfusion rate and the thermal conductivities of both frozen and unfrozen tissues...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29037215/melanoma-brain-metastases-treated-with-stereotactic-radiosurgery-and-concurrent-pembrolizumab-display-marked-regression-efficacy-and-safety-of-combined-treatment
#5
Erik S Anderson, Michael A Postow, Jedd D Wolchok, Robert J Young, Åse Ballangrud, Timothy A Chan, Yoshiya Yamada, Kathryn Beal
BACKGROUND: Brain metastases are common in patients with metastatic melanoma. With increasing numbers of melanoma patients on anti-PD-1 therapy, we sought to evaluate the safety and initial response of brain metastases treated with concurrent pembrolizumab and radiation therapy. METHODS: From an institutional database, we retrospectively identified patients with melanoma brain metastases treated with radiation therapy (RT) who received concurrent pembrolizumab. Concurrent treatment was defined as RT during pembrolizumab administration period and up to 4 months after most recent pembrolizumab treatment...
October 17, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/29035208/an-efficient-integral-based-method-for-three-dimensional-mr-ept-and-the-calculation-of-the-rf-coil-induced-field
#6
Lei Guo, Jin Jin, Chunyi Liu, Feng Liu, Stuart Crozier
Magnetic resonance electrical property tomography (MR-EPT) has significant potential for the estimation of the electrical properties (EPs) of tissue, which are essential for the calculation of specific absorption rates (SAR), a critical safety factor requiring monitoring and controlling in applications of ultra-high field magnetic resonance imaging (MRI). In this paper, a novel, efficient method based on integral equations is proposed for the calculation of the EPs and the RF-coil induced field. An inverse problem framework is first constructed to include the forward problem operator, while the EPs are reconstructed by using a non-linear conjugate gradient method (NLCG)...
October 16, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29024404/removal-of-sacral-nerve-stimulation-devices-for-magnetic-resonance-imaging-what-happens-next
#7
Jessica C Lloyd, Bradley C Gill, Javier Pizarro-Berdichevsky, Howard B Goldman
INTRODUCTION: Sacral neuromodulation (SNM) devices (Medtronic, Minneapolis, MN, USA) are not approved to undergo magnetic resonance imaging (MRI) of sites other than the head. When MRIs are required, devices are often removed prior to imaging. We reviewed the prevalence of device removal for MRI at a large academic institution and the subsequent clinical course of these patients. METHODS: A retrospective review of all SNM explants from 2009-2015 was performed. Cases explanted for MRI were analyzed to collect demographics, clinical characteristics, and postremoval management...
October 11, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29021849/feasibility-safety-and-potential-demand-of-emergent-brain-magnetic-resonance-imaging-of-patients-with-cardiac-implantable-electronic-devices
#8
Maki Ono, Makoto Suzuki, Mitsuaki Isobe
BACKGROUND: The feasibility, safety, and potential demand of emergent magnetic resonance imaging (MRI) of patients with a cardiac implantable electronic device (CIED) in emergency situations are unknown. METHODS: We retrospectively compared emergent and scheduled MRI orders for patients with CIEDs at Kameda General Hospital, a tertiary hospital in Japan, from October 2012 to September 2016. RESULTS: We identified 11 emergent MRI orders via the emergency room and 38 scheduled MRI orders...
October 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/29017930/cardiac-magnetic-resonance-imaging-using-wideband-sequences-in-patients-with-non-conditional-cardiac-implanted-electronic-devices
#9
Duc H Do, Vaughn Eyvazian, Aileen J Bayoneta, Peng Hu, J Paul Finn, Jason S Bradfield, Kalyanam Shivkumar, Noel G Boyle
BACKGROUND: Magnetic resonance imaging (MRI) has been performed safely in patients without MRI-conditional cardiac implantable electronic devices (CIED), but experience specifically with cardiac magnetic resonance imaging (CMR) is limited in this patient population. OBJECTIVE: Evaluate the safety of CMR in non-MRI-conditional CIED and the interpretability of images using wideband sequences. METHODS: We performed 114 consecutive CMR studies in 111 patients (mean age 59±14 years with 12 pacemakers, 73 implantable cardioverter defibrillators, 29 biventricular defibrillators) utilizing a wideband pulse sequence for late gadolinium enhancement (LGE) imaging...
October 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29016185/clinical-outcomes-of-knee-osteoarthritis-treated-with-an-autologous-protein-solution-injection-a-1-year-pilot-double-blinded-randomized-controlled-trial
#10
Elizaveta Kon, Lars Engebretsen, Peter Verdonk, Stefan Nehrer, Giuseppe Filardo
BACKGROUND: Osteoarthritis (OA) is a debilitating disease resulting in substantial pain and functional limitations. A novel blood derivative has been developed to concentrate both growth factors and antagonists of inflammatory cytokines, with promising preliminary findings in terms of safety profile and clinical improvement. PURPOSE: To investigate if one intra-articular injection of autologous protein solution (APS) can reduce pain and improve function in patients affected by knee OA in a multicenter, randomized, double-blind, saline-controlled study...
October 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28992723/severe-cerebellar-hemorrhage-following-transverse-sinus-stenting-for-idiopathic-intracranial-hypertension
#11
Pascale Lavoie, Marie-Ève Audet, Jean-Luc Gariepy, Martin Savard, Steve Verreault, Alain Gourdeau, Geneviève Milot, Sylvine Carrondo Cottin
We report a severe adverse event occurring in the course of a cohort study (ISRCTN13784335) aimed at measuring the efficacy and safety of venous stenting in the treatment of patients with medically refractory idiopathic intracranial hypertension (IIH). The patient was a 41-year-old woman who was not overweight, who presented with severe headache, grade 1 bilateral papilledema and transient tinnitus, refractory to medical treatment. Right transverse sinus stenting was successfully performed. Following surgery, the patient's state of consciousness decreased acutely with rapid and progressive loss of brainstem reflex...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28983222/transoral-approach-for-odontoidectomy-efficacy-and-safety
#12
Ahmed Mohamed Elbadrawi, Tameem Mohamed Elkhateeb
BACKGROUND: Odontoid process pathologies can cause upper motor neuron lesions. These pathologies can be approached through either a high retropharyngeal approach or a transoral approach. The introduction of the surgical microscope, proper instrumentations, and proper antibiotics has increased utilization of the transoral approach. QUESTIONS/PURPOSES: Our approach to anterior odontoid resection through transoral approach for different pathologies resulting in compression the cervical cord or causing craniocervical instability is described here...
October 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28977797/evaluation-of-magnetic-resonance-imaging-safety-and-imaging-issues-associated-with-the-occlusion-balloon-used-during-fetoscopic-endoluminal-tracheal-occlusion
#13
Teresa Victoria, Ann M Johnson, N Scott Adzick, Holly L Hedrick, Frank G Shellock
INTRODUCTION: Congenital diaphragmatic hernias can be successfully treated by fetoscopic tracheal occlusion (FETO), a minimally invasive procedure that may improve postnatal survival. The endoluminal balloon utilized for FETO contains a metallic component that may pose possible risks for the fetus and mother related to the use of magnetic resonance imaging (MRI). The objective of this study is to evaluate MRI-related imaging and safety issues (magnetic field interactions, heating, and artifacts) for the occlusion balloon used in FETO...
October 5, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28976817/hematopoietic-stem-cell-gene-therapy-for-cerebral-adrenoleukodystrophy
#14
Florian Eichler, Christine Duncan, Patricia L Musolino, Paul J Orchard, Satiro De Oliveira, Adrian J Thrasher, Myriam Armant, Colleen Dansereau, Troy C Lund, Weston P Miller, Gerald V Raymond, Raman Sankar, Ami J Shah, Caroline Sevin, H Bobby Gaspar, Paul Gissen, Hernan Amartino, Drago Bratkovic, Nicholas J C Smith, Asif M Paker, Esther Shamir, Tara O'Meara, David Davidson, Patrick Aubourg, David A Williams
Background In X-linked adrenoleukodystrophy, mutations in ABCD1 lead to loss of function of the ALD protein. Cerebral adrenoleukodystrophy is characterized by demyelination and neurodegeneration. Disease progression, which leads to loss of neurologic function and death, can be halted only with allogeneic hematopoietic stem-cell transplantation. Methods We enrolled boys with cerebral adrenoleukodystrophy in a single-group, open-label, phase 2-3 safety and efficacy study. Patients were required to have early-stage disease and gadolinium enhancement on magnetic resonance imaging (MRI) at screening...
October 4, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28976586/an-8-channel-transceiver-7-channel-receive-rf-coil-setup-for-high-snr-ultrahigh-field-mri-of-the-shoulder-at-7t
#15
Stefan H G Rietsch, Viktor Pfaffenrot, Andreas K Bitz, Stephan Orzada, Sascha Brunheim, Andrea Lazik-Palm, Jens M Theysohn, Mark E Ladd, Harald H Quick, Oliver Kraff
PURPOSE: In this work, we present an 8-channel transceiver (Tx/Rx) 7-channel receive (Rx) radiofrequency (RF) coil setup for 7T ultrahigh-field MR imaging of the shoulder. METHODS: A C-shaped 8-channel Tx/Rx coil was combined with an anatomically close-fitting 7-channel Rx-only coil. The safety and performance parameters of this coil setup were evaluated on the bench and in phantom experiments. The 7T MR imaging performance of the shoulder RF coil setup was evaluated in in vivo measurements using a 3D DESS, a 2D PD-weighted TSE sequence, and safety supervision based on virtual observation points...
October 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28975718/effects-of-febuxostat-in-early-gout-a-randomized-double-blind-placebo-controlled-study
#16
Nicola Dalbeth, Kenneth G Saag, William E Palmer, Hyon K Choi, Barbara Hunt, Patricia A MacDonald, Ulrich Thienel, Lhanoo Gunawardhana
OBJECTIVES: To assess the effect of treatment with febuxostat vs placebo on joint damage in hyperuricemic subjects with early gout (experienced ≤2 gout flares). METHODS: In this double-blind, placebo-controlled study, subjects (n = 314) with hyperuricemia (serum uric acid [sUA] ≥7.0 mg/dL) and early gout were randomized 1:1 to receive once-daily febuxostat 40 mg (increased to 80 mg if sUA ≥6.0 mg/dL at day 14) or placebo. The primary efficacy endpoint was mean change from baseline (CFB) to month 24 in the modified Sharp-van der Heijde (mSvdH) erosion score from the single affected joint X-rays...
October 4, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28972742/ultra-small-paramagnetic-iron-oxide-nanoprobe-targeting-egfr-for-in-vivo-mr-imaging-of-hepatocellular-carcinoma
#17
Yan Chen, Quan Zhou, Xue Li, Fa Wang, Kevin Heist, Rork D Kuick, Scott Owens, Thomas Wang
Hepatocellular carcinoma (HCC) is a common worldwide cancer that is rising rapidly in incidence. MRI is a powerful non-invasive imaging modality for HCC detection but lack of specific contrast agents limits visualization of small tumors. EGFR is frequently overexpressed in HCC and is a promising target. Peptides have fast binding kinetics, short circulatory half-life, low imaging background, high vascular permeability, and enhanced tissue diffusion for deep tumor penetration. We demonstrate a peptide specific for EGFR labeled with an ultra-small paramagnetic iron oxide (UPIO) nanoparticle with 3...
October 3, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28970702/generic-direct-acting-antivirals-in-treatment-of-chronic-hepatitis-c-infection-in-patients-of-thalassemia-major
#18
Aabha Nagral, Smita Sawant, Nishtha Nagral, Pathik Parikh, Priya Malde, Rashid Merchant
BACKGROUND: There is no published data of treating hepatitis C in thalassemia major patients with any sofosbuvir based direct acting antivirals (DAAs). This study was performed to determine the efficacy and safety of these regimes using generic drugs in the thalassemia major population. METHODS: In this observational study, 902 patients of thalassemia major from five transfusion centres in Mumbai were screened for HCV antibody. Of the 120 positive patients, HCV RNA was detected in 50%...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28962909/phase-i-ii-trial-of-combined-kyphoplasty-and-intraoperative-radiotherapy-in-spinal-metastases
#19
Frederic Bludau, Grit Welzel, Tina Reis, Frank Schneider, Elena Sperk, Christian Neumaier, Michael Ehmann, Sven Clausen, Udo Obertacke, Frederik Wenz, Frank A Giordano
BACKGROUND CONTEXT: Spinal metastases occur in 30-50% of patients with systemic cancer. The primary goals of palliation are pain control and prevention of local recurrence. PURPOSE: To test the safety and efficacy of a combined modality approach consisting of kyphoplasty and intraoperative radiotherapy (kypho-IORT). STUDY DESIGN/SETTING: Kypho-IORT was a prospective, single center phase I/II trial. Patients were enrolled in a classical 3+3 scheme within the initial phase I part, where Kypho-IORT was applied using a needle-shaped 50 kV X-ray source at three radiation dose levels (8 Gy in 8 mm, 8 Gy in 11 mm and 8 Gy in 13 mm depth)...
September 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28961381/mesenchymal-stem-cells-and-conditioned-media-in-the-treatment-of-multiple-sclerosis-patients-clinical-ophthalmological-and-radiological-assessments-of-safety-and-efficacy
#20
Said Dahbour, Fatima Jamali, Dana Alhattab, Ali Al-Radaideh, Osama Ababneh, Nosaiba Al-Ryalat, Muawyeh Al-Bdour, Bayan Hourani, Mohammed Msallam, Murad Rasheed, Ammar Huneiti, Yacoub Bahou, Emad Tarawneh, Abdalla Awidi
AIMS: This open-label prospective phase I/IIa clinical study used autologous bone marrow-derived mesenchymal stromal cells (BM-MSCs) followed by mesenchymal stromal cells conditioned media (MSC-CM) for the first time to treat multiple sclerosis (MS) patients. The primary goal was to assess the safety and feasibility and the secondary was efficacy. The correlation between the MSC-CM content and treatment outcome was investigated. METHODS: Ten MS patients who failed conventional therapy were enrolled...
November 2017: CNS Neuroscience & Therapeutics
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