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https://www.readbyqxmd.com/read/29914842/ablative-stereotactic-neurosurgery-for-irreducible-neuroaggressive-disorder-in-pediatric-patients
#1
Manuel Hernández Salazar, Antonio Zarate Méndez, Oscar Meneses Luna, Lucía Ledesma Torres, Ramón Paniagua Sierra, Mary Carmen Sánchez Moreno, Juan Leonardo Serrato Avila
INTRODUCTION AND OBJECTIVES: The irreducible neuroaggressive disorder (IND) is a well-described entity known to be associated with impulsive and aggressive behavior. While various studies have assessed available pharmacological and non-pharmacological treatment regimens, patients with IND continue to pose a major threat to themselves and society. While targeted stereotactic therapy for IND has gained traction in recent years, there is a paucity of information describing comparative effectiveness of different validated anatomic regions...
June 15, 2018: Neurocirugía
https://www.readbyqxmd.com/read/29913906/using-fmri-to-evaluate-the-effects-of-milnacipran-on-central-pain-processing-in-patients-with-fibromyalgia
#2
F Petzke, K B Jensen, E Kosek, E Choy, S Carville, P Fransson, S C R Williams, H Marcus, Y Mainguy, M Ingvar, R H Gracely
Background In recent years, the prescription of serotonin-noradrenalin reuptake inhibitors (SNRIs) for treatment of fibromyalgia (FM) has increased with reports of their efficacy. The SNRI milnacipran is approved by the U.S. Food and Drug Administration (FDA) for treatment of FM, yet, the mechanisms by which milnacipran reduces FM symptoms are unknown. A large number of neuroimaging studies have demonstrated altered brain function in patients with FM but the effect of milnacipran on central pain processing has not been investigated...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29910056/rationale-and-design-of-the-seneca-stem-cell-injection-in-cancer-survivors-trial
#3
Roberto Bolli, Joshua M Hare, Timothy D Henry, Carrie G Lenneman, Keith L March, Kathy Miller, Carl J Pepine, Emerson C Perin, Jay H Traverse, James T Willerson, Phillip C Yang, Adrian P Gee, João A Lima, Lem Moyé, Rachel W Vojvodic, Shelly L Sayre, Judy Bettencourt, Michelle Cohen, Ray F Ebert, Robert D Simari
OBJECTIVES: SENECA (StEm cell iNjECtion in cAncer survivors) is a phase I, randomized, double-blind, placebo-controlled study to evaluate the safety and feasibility of delivering allogeneic mesenchymal stromal cells (allo-MSCs) transendocardially in subjects with anthracycline-induced cardiomyopathy (AIC). BACKGROUND: AIC is an incurable and often fatal syndrome, with a prognosis worse than that of ischemic or nonischemic cardiomyopathy. Recently, cell therapy with MSCs has emerged as a promising new approach to repair damaged myocardium...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29903424/midterm-results-of-magnum-large-head-metal-on-metal-total-hip-arthroplasty
#4
I Aguado-Maestro, E Cebrián Rodríguez, E Paredes Herrero, F Brunie Vegas, M Oñate Miranda, N Fernández García, M García Alonso
OBJECTIVES: We present the results of the prospective follow up of a sample of large head metal-metal total hip arthroplasty obtained after the safety alert regarding a higher incidence of revision of these implants. MATERIAL AND METHODS: All patients implanted with the Recap-M2a-Magnum cup between 2008 and 2011 were included. They were prospectively reviewed recording Harris Hip Score, clinical symptoms of chromium or cobalt intoxication. Serum levels of these ions were requested as well as X-Rays and ultrasonography...
June 11, 2018: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/29898747/recurrence-pattern-analysis-after-68-ga-dotatate-pet-ct-planned-radiotherapy-of-high-grade-meningiomas
#5
Barbara Zollner, Ute Ganswindt, Cornelius Maihöfer, Stefanie Corradini, Nathalie Lisa Albert, Christian Schichor, Claus Belka, Maximilian Niyazi
BACKGROUND: The aim of the present study was to evaluate the influence of the applied safety margins of modern intensity-modulated radiotherapy (IMRT) in patients with high-grade meningiomas on local control and recurrence patterns. METHODS: Twenty patients with a neuropathological diagnosis of a high-grade meningioma (WHO°II or °III) treated with adjuvant or definitive radiotherapy between 2010 and 2015 were included in the present retrospective analysis. All patients were planned PET-based...
June 14, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29896293/three-dimensional-transcranial-microbubble-imaging-for-guiding-volumetric-ultrasound-mediated-blood-brain-barrier-opening
#6
Ryan M Jones, Lulu Deng, Kogee Leung, Dallan McMahon, Meaghan A O'Reilly, Kullervo Hynynen
Focused ultrasound (FUS)-mediated blood-brain barrier (BBB) opening recently entered clinical testing for targeted drug delivery to the brain. Sources of variability exist in the current procedures, motivating the development of real-time monitoring and control techniques to improve treatment safety and efficacy. Here we used three-dimensional (3D) transcranial microbubble imaging to calibrate FUS exposure levels for volumetric BBB opening. Methods: Using a sparse hemispherical transmit/receive ultrasound phased array, pulsed ultrasound was focused transcranially into the thalamus of rabbits during microbubble infusion and multi-channel 3D beamforming was performed online with receiver signals captured at the subharmonic frequency...
2018: Theranostics
https://www.readbyqxmd.com/read/29887966/combined-magnetic-resonance-imaging-and-optical-surgical-navigation-system-guidance-of-percutaneous-liver-cryoablation-in-a-porcine-model
#7
Kang Zhou, Zhuoli Zhang, Matteo Figini, Junjie Shangguan, Yining Wang, Haifeng Shi, Yumei Li, Zhengyu Jin, Jie Pan
The efficacy and safety of combining open-configuration magnetic resonance imaging (MRI) and an optical surgical navigation system (OSNS) for guidance of percutaneous liver cryoablation were evaluated in a pig model. This approach was successfully executed in eight test pigs under general anesthesia. Another two pigs spared from ablation served as controls. MRI studies, blood testing, and pathologic examinations were performed at various time points. MRI-determined minimal and maximal cryolesion diameters were 19...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29885994/bevacizumab-monotherapy-reduces-radiation-induced-brain-necrosis-in-nasopharyngeal-carcinoma-patients-a-randomized-controlled-trial
#8
Yongteng Xu, Xiaoming Rong, Weihan Hu, Xiaolong Huang, Yi Li, Dong Zheng, Zhaoxi Cai, Zhiyi Zuo, Yamei Tang
PURPOSE: Studies have shown that addition of bevacizumab to corticosteroids improves outcome against radiation-induced brain necrosis (RN). Here, we aimed to evaluate the effectiveness and safety of bevacizumab monotherapy on RN in nasopharyngeal carcinoma (NPC) patients. METHODS AND MATERIALS: In this multicenter open-label study, patients with RN were randomly assigned (1:1) into a bevacizumab group (5 mg/kg intravenously every 2 weeks, for 4 cycles) or a corticosteroid group (methylprednisolone 500 mg/day intravenously for 3 consecutive days and then gradually tapered, followed by 10 mg/day oral prednisone, for 2 months in total)...
May 2, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29883828/safety-of-dynamic-mri-of-the-cervical-spine-in-children-performed-without-neurosurgical-supervision
#9
Derek Yecies, Nathaniel Fogel, Michael Edwards, Gerald Grant, Kristen W Yeom, Samuel Cheshier
OBJECT: The need for neurosurgical supervision as well as the general safety and utility of dynamic MRI of the cervical spine in children remains controversial. We present the largest descriptive cohort study of cervical flexion-extension MRIs in a pediatric population to help elucidate the safety and utility of this technique. METHODS: All cervical spine MRIs performed at Lucile Packard Children's Hospital at Stanford from 2009-2015 were retrospectively reviewed...
June 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29883617/3d-printed-specimens-as-a-valuable-tool-in-anatomy-education-a-pilot-study
#10
Monique Garas, Mauro Vaccarezza, George Newland, Kylie McVay-Doornbusch, Jamila Hasani
Three-dimensional (3D) printing is a modern technique of creating 3D-printed models that allows reproduction of human structures from MRI and CT scans via fusion of multiple layers of resin materials. To assess feasibility of this innovative resource as anatomy educational tool, we conducted a preliminary study on Curtin University undergraduate students to investigate the use of 3D models for anatomy learning as a main goal, to assess the effectiveness of different specimen types during the sessions and personally preferred anatomy learning tools among students as secondary aim...
June 5, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29870642/-is-second-line-immunomodulatory-treatment-effective-in-multiple-sclerosis
#11
Lilla Rácz, Ervin Berényi, Péter Barsi, Dávid Bernáth, Tünde Csépány
Background and purpose: Natalizumab is the first evidence based monoclonal antibody, which was launched for treatment in relapsing remitting multiple sclerosis in Hungary in 2010. Standardized follow-up is required to use it. Methods: Our aim was to evaluate the efficacy and to monitor the safety of natalizumab treatment by using an electronic database established for MS registry. Clinical activity was measured by annual relapse rates, functional status of patients measured by EDSS and MFSC...
July 30, 2017: Ideggyógyászati Szemle
https://www.readbyqxmd.com/read/29868638/endoscopic-electrochemotherapy-for-esophageal-cancer-a-phase-i-clinical-study
#12
Charlotte Egeland, Lene Baeksgaard, Helle Hjorth Johannesen, Johan Löfgren, Christina Caroline Plaschke, Lars Bo Svendsen, Julie Gehl, Michael Patrick Achiam
Background and study aims:  Esophageal cancer is on the rise in the western world and the disease has a poor 5-year survival prognosis below 20 %. Electrochemotherapy is a treatment where a chemotherapeutic drug is combined with locally applied electrical pulses, in order to increase the drug's cytotoxicity in malignant cells. This study presents the first results with electrochemotherapy treatment in esophageal cancer. Patients and methods:  In this first-in-human trial, six patients with advanced esophageal cancer were treated with electrochemotherapy using intravenous bleomycin...
June 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29866347/occupational-exposure-to-electromagnetic-fields-the-situation-in-greece
#13
G A Gourzoulidis, P Tsaprouni, Ν Skamnakis, C Tzoumanika, E Kalampaliki, E Karastergios, A Gialofas, A Achtipis, C Kappas, E Karabetsos
PURPOSE: The management of the occupational exposure to electromagnetic fields (EMF), an Occupational Health and Safety (OHS) issue of great scientific, social and economic significance, was under intense negotiations at European level over the last twenty years; the Directive 2013/35/EU is the new legislative tool. The presented study deals with the practical aspects of the Directive's implementation. METHODS: The appropriate, extensive measurements and the overall EMF exposure assessments (i...
May 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29862030/pre-edit-protocol-for-a-randomised-feasibility-trial-of-elastance-directed-intrapleural-catheter-or-talc-pleurodesis-edit-in-malignant-pleural-effusion
#14
Geoffrey A Martin, Selina Tsim, Andrew C Kidd, John E Foster, Philip McLoone, Anthony Chalmers, Kevin G Blyth
Introduction: Non-expansile lung (NEL) is a common cause of talc pleurodesis (TP) failure in malignant pleural effusion (MPE), but is often occult prior to drainage. Reliable detection of NEL would allow patients to be allocated between intrapleural catheter (IPC) and TP. High pleural elastance (PEL ) has been associated with NEL in observational studies. Pre-EDIT is a randomised feasibility trial of elastance-directed IPC or TP (EDIT) management using a novel, purpose-built digital pleural manometer (Rocket Medical, UK)...
2018: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29858946/homologous-cryopreserved-amniotic-membrane-in-the-repair-of-myelomeningocele-preliminary-experience
#15
Elisabetta Marton, Enrico Giordan, Giorgio Gioffrè, Giuseppe Canova, Adolfo Paolin, Marina Grazia Mazzucco, Pierluigi Longatti
OBJECTIVE: Surgical management of spinal dysraphism often requires the use of dural substitutes. Amniotic membrane (AM) has drawn the interest of clinicians for its valuable concentration of cytokines and factors capable of promoting wound healing, re-epithelialization, inhibiting fibrosis and regulating angiogenesis. These beneficial qualities could make AM an interesting dural substitute for spina bifida repair. In this study, we describe the use of banked homologous AM as a dural substitute for the repair of spinal dysraphism in newborns...
June 1, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29852181/can-lumbosacral-magnetic-resonance-imaging-be-performed-safely-in-patients-with-a-sacral-neuromodulation-device-an-in-vivo-prospective-study
#16
Juan M Guzman-Negron, Javier Pizarro-Berdichevsky, Bradley C Gill, Howard B Goldman
PURPOSE: To determine the safety of sacral neuromodulation (SNM) in patients during lumbosacral 1.5 T magnetic resonance imaging (MRI). METHODS: We prospectively recruited SNM-implanted patients requiring lumbosacral 1.5 T MRI. Before imaging, patients completed validated urinary symptom questionnaires and a survey regarding their usual SNM sensation. The implantable pulse generator (IPG) was interrogated, with impedances, battery life, and stimulus amplitude sensory thresholds assessed pre and post-MRI...
May 28, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29850940/pituitary-adenomas-in-children-and-young-adults
#17
Kara Leigh Krajewski, Roman Rotermund, Jörg Flitsch
PURPOSE: Pituitary adenomas are rare in the pediatric population. We present a recent cohort of children operated transsphenoidally on pituitary adenoma from a single center. METHODS: Inclusion criteria were age < 21 years and histopathological diagnosis of adenoma after transsphenoidal surgery. The electronic file was used for prospective and retrospective data collection on symptoms, pituitary function before/after surgical intervention, and surgical complications...
May 30, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29850938/intramuscular-venous-malformations-of-the-upper-and-lower-limbs-indications-and-outcomes-of-sclerotherapy
#18
Giuseppe Bianchini, Daniele Camilli, Sergio Furgiuele
PURPOSE: Multiple treatment options have been described for intramuscular venous malformations (VMs) of the limbs. At the current time, there are no clear management guidelines. The aim was to evaluate efficacy and safety of sclerotherapy in this type of VMs. MATERIALS AND METHODS: This is a single-center, retrospective review of patients treated for extremity intramuscular VMs between January 2013 and June 2017. The primary outcomes were the improvement of symptoms self-assessed by questionnaires, and the reduction in VM size measured by magnetic resonance (MRI)...
May 30, 2018: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/29850561/functional-assessment-of-intermediate-vascular-disease
#19
REVIEW
Teodora Yaneva-Sirakova, Ivanichka Serbezova, Dobrin Vassilev
Interventional treatment in various vascular beds has advanced tremendously. However, there are several problems to be considered. We searched the literature and tried to analyze major parts of it. One is safety and applicability of coronary proven methods in other vascular beds. An unresolved problem is the functional assessment of intermediate lesions, as far as various target organs have quite different circulation from the coronary one and the functional tests should be modified in order to be applicable and meaningful...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29848399/safety-of-ferumoxytol-in-children-undergoing-cardiac-mri-under-general-anaesthesia
#20
Lisa Wise-Faberowski, Nathalia Velasquez, Frandics Chan, Shreyas Vasanawala, Doff B McElhinney, Chandra Ramamoorthy
BACKGROUND: Ferumoxytol, an "off-label" contrast agent, allows for better cardiac MRI quality as compared with gadolinium-based contrast agents. However, hypotension has been reported with the use of ferumoxytol for indications other than cardiac MRI. The purpose of our investigation was to evaluate the safety of ferumoxytol in children undergoing general anaesthesia for cardiac MRI. METHODS: Medical records of children undergoing general anaesthesia for cardiac MRI were reviewed...
July 2018: Cardiology in the Young
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