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Stephen Bischof

Takeshi Omura, Mohammed Asieri, Kirsten Bischof, Sharan Rambarran, Maeyane Stephens Moeng
Thoracic oesophageal gunshot injuries are uncommon, and the morbidity and mortality rates are extremely high and depend on the elapsed time, injury severity, and concomitant organ damage. Thus, early diagnosis is paramount to avoid delays, which in turn confer poorer outcomes. Current management strategies are still controversial and depend on the patient's physiologic state. We experienced two cases of thoracic oesophageal gunshot injury, both of whom were treated by primary repair and were successfully discharged...
December 2017: Trauma Case Reports
Antje Bischof, Eduardo Caverzasi, Christian Cordano, Stephen L Hauser, Roland G Henry
No abstract text is available yet for this article.
October 2017: Seminars in Neurology
Erica L Eggers, Brady A Michel, Hao Wu, Sheng-Zhi Wang, Carolyn J Bevan, Aya Abounasr, Natalie S Pierson, Antje Bischof, Max Kazer, Elizabeth Leitner, Ariele L Greenfield, Stanislas Demuth, Michael R Wilson, Roland G Henry, Bruce Ac Cree, Stephen L Hauser, H-Christian von Büdingen
A role of B cells in multiple sclerosis (MS) is well established, but there is limited understanding of their involvement during active disease. Here, we examined cerebrospinal fluid (CSF) and peripheral blood (PB) B cells in treatment-naive patients with MS or high-risk clinically isolated syndrome. Using flow cytometry, we found increased CSF lymphocytes with a disproportionate increase of B cells compared with T cells in patients with gadolinium-enhancing (Gd+) lesions on brain MRI. Ig gene heavy chain variable region (Ig-VH) repertoire sequencing of CSF and PB B cells revealed clonal relationships between intrathecal and peripheral B cell populations, which could be consistent with migration of B cells to and activation in the CNS in active MS...
November 16, 2017: JCI Insight
H-Christian von Büdingen, Antje Bischof, Erica L Eggers, Shengzhi Wang, Carolyn J Bevan, Bruce A C Cree, Roland G Henry, Stephen L Hauser
A patient with relapsing multiple sclerosis (RMS) was treated with a standard immunomodulatory therapy, but due to ongoing disease activity was switched to rituximab. Relapses ceased, but secondary progressive MS (SPMS) eventually appeared, associated with new focal spinal cord white matter lesions. Cerebrospinal fluid (CSF) showed persistent oligoclonal bands (OCB) and clonally related B cells in CSF and peripheral blood. The treatment escalation approach failed to prevent evolution to SPMS, raising the question of whether initiation of B-cell depleting therapy at the time of RMS diagnosis should be tested to more effectively address the immune pathology leading to SPMS...
January 2017: Annals of Clinical and Translational Neurology
Ryan P Goff, Stephen G Quallich, Robert A Buechler, John C Bischof, Paul A Iaizzo
Despite widespread clinical use of cryoablation, there remain questions regarding dosing and treatment times which may affect efficacy and collateral injury. Dosing and treatment times are directly related to the degree of cooling necessary for effective lesion formation. Human and swine atrial, ventricular, and lung tissues were ablated using two cryoablation systems with concurrent infrared thermography. Post freeze-thaw samples were cultured and stained to differentiate viable and non-viable tissue. Matlab code correlated viability staining to applied freeze-thaw thermal cycles, to determine injury thresholds...
April 2017: Cryobiology
Evelina A Zimovetz, Stephen M Beard, Paul Hodgkins, Matthias Bischof, Josephine A Mauskopf, Juliana Setyawan
BACKGROUND: An economic analysis from the perspective of the UK National Health Service (NHS) evaluated the cost effectiveness of lisdexamfetamine dimesylate (LDX) compared with atomoxetine in children and adolescents with attention-deficit/hyperactivity disorder who have had an inadequate response to methylphenidate. METHODS: A 1-year decision-analytic model was constructed, with the health outcomes "response", "nonresponse", and "unable to tolerate". Clinical data were taken from a head-to-head, randomized controlled trial in inadequate responders to methylphenidate...
October 2016: CNS Drugs
Anisha Keshavan, Friedemann Paul, Mona K Beyer, Alyssa H Zhu, Nico Papinutto, Russell T Shinohara, William Stern, Michael Amann, Rohit Bakshi, Antje Bischof, Alessandro Carriero, Manuel Comabella, Jason C Crane, Sandra D'Alfonso, Philippe Demaerel, Benedicte Dubois, Massimo Filippi, Vinzenz Fleischer, Bertrand Fontaine, Laura Gaetano, An Goris, Christiane Graetz, Adriane Gröger, Sergiu Groppa, David A Hafler, Hanne F Harbo, Bernhard Hemmer, Kesshi Jordan, Ludwig Kappos, Gina Kirkish, Sara Llufriu, Stefano Magon, Filippo Martinelli-Boneschi, Jacob L McCauley, Xavier Montalban, Mark Mühlau, Daniel Pelletier, Pradip M Pattany, Margaret Pericak-Vance, Isabelle Cournu-Rebeix, Maria A Rocca, Alex Rovira, Regina Schlaeger, Albert Saiz, Till Sprenger, Alessandro Stecco, Bernard M J Uitdehaag, Pablo Villoslada, Mike P Wattjes, Howard Weiner, Jens Wuerfel, Claus Zimmer, Frauke Zipp, Stephen L Hauser, Jorge R Oksenberg, Roland G Henry
A concern for researchers planning multisite studies is that scanner and T1-weighted sequence-related biases on regional volumes could overshadow true effects, especially for studies with a heterogeneous set of scanners and sequences. Current approaches attempt to harmonize data by standardizing hardware, pulse sequences, and protocols, or by calibrating across sites using phantom-based corrections to ensure the same raw image intensities. We propose to avoid harmonization and phantom-based correction entirely...
July 1, 2016: NeuroImage
Johanna E Bischof, Christine Worrall, Peter Thompson, David Marti, Stephen W Smith
BACKGROUND: ST-segment elevation (STE) due to inferior STE myocardial infarction (STEMI) may be misdiagnosed as pericarditis. Conversely, this less life-threatening etiology of ST elevation may be confused for inferior STEMI. We sought to determine if the presence of any ST-segment depression in lead aVL would differentiate inferior STEMI from pericarditis. METHODS: Retrospective study of 3 populations. Cohort 1 included patients coded as inferior STEMI, cohort 2 included patients with a discharge diagnosis of pericarditis who presented with chest pain and at least 0...
February 2016: American Journal of Emergency Medicine
Josh B Ballard, Don D Dick, Stephen J McDonnell, Maia Bischof, Joseph Fu, James H G Owen, William R Owen, Justin D Alexander, David L Jaeger, Pradeep Namboodiri, Ehud Fuchs, Yves J Chabal, Robert M Wallace, Richard Reidy, Richard M Silver, John N Randall, James Von Ehr
Reducing the scale of etched nanostructures below the 10 nm range eventually will require an atomic scale understanding of the entire fabrication process being used in order to maintain exquisite control over both feature size and feature density. Here, we demonstrate a method for tracking atomically resolved and controlled structures from initial template definition through final nanostructure metrology, opening up a pathway for top-down atomic control over nanofabrication. Hydrogen depassivation lithography is the first step of the nanoscale fabrication process followed by selective atomic layer deposition of up to 2...
July 17, 2015: Journal of Visualized Experiments: JoVE
Jing Jiang, Raghav Goel, Stephen Schmechel, Gregory Vercellotti, Colleen Forster, John Bischof
Cryosurgery is increasingly being used to treat prostate cancer; however, a major limitation is local recurrence of disease within the previously frozen tissue. We have recently demonstrated that tumor necrosis factor alpha (TNF-α), given 4h prior to cryosurgery can yield complete destruction of prostate cancer within a cryosurgical iceball. The present work continues the investigation of the cellular and molecular mechanisms and dynamics of TNF-α enhancement on cryosurgery. In vivo prostate tumor (LNCaP Pro 5) was grown in a dorsal skin fold chamber (DSFC) on a male nude mouse...
December 2010: Cryobiology
Daniela Bischof, Sherine F Elsawa, George Mantchev, Juhan Yoon, Grace E Michels, Allan Nilson, Shari L Sutor, Jeffrey L Platt, Stephen M Ansell, Gotz von Bulow, Richard J Bram
B-lymphocyte homeostasis and function are regulated by complementary actions of the TNFR family members TACI, BCMA, and BAFF-R, which are expressed by mature B cells. How these receptors are differentially activated is not entirely understood, because the primary ligand BAFF binds to all three. We searched for alternative ligands for TACI using recombinant TACI-Fc fusion protein as a probe and identified syndecan-2 as a new binding partner. TACI binding appears to require heparan sulfate posttranslational modifications of syndecan-2, because free heparin or pretreatment with heparitinase blocked the interaction...
April 15, 2006: Blood
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