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https://www.readbyqxmd.com/read/29355816/does-status-epilepticus-modify-the-effect-of-ifenprodil-on-cortical-epileptic-afterdischarges-in-immature-rats
#1
Kenul Abbasova, Hana Kubová, Pavel Mareš
BACKGROUND: Ifenprodil as a specific antagonist of NMDA receptors containing a dominant NR2B subunit exhibits age-dependent anticonvulsant action. Possible changes of this action due to status epilepticus (SE) elicited at early stage of development were studied using cortical epileptic afterdischarges (ADs) as a model. METHODS: Lithium-pilocarpine SE was induced at postnatal day 12 and effects of ifenprodil were studied 3, 6, 9, and 13 days after SE in rat pups with implanted epidural electrodes...
August 26, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29355640/cannabinoids-induce-apathetic-and-impulsive-patterns-of-choice-through-cb1-receptors-and-trpv1-channels
#2
Zahra Fatahi, Zahra Reisi, Gregor Rainer, Abbas Haghparast, Abbas Khani
Despite evidence from psychiatry and psychology clinics pointing to altered cognition and decision making following the consumption of cannabis, the effects of cannabis derivatives are still under dispute and the mechanisms of cannabinoid effects on cognition are not known. In this study, we used effort-based and delay-based decision tasks and showed that ACEA, a potent cannabinoid agonist induced apathetic and impulsive patterns of choice in rats in a dose-dependent manner when locally injected into the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC), respectively...
January 17, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29355599/stable-isotope-compounds-production-detection-and-application
#3
REVIEW
Vilém Zachleder, Milada Vítová, Monika Hlavová, Šárka Moudříková, Peter Mojzeš, Hermann Heumann, Johannes R Becher, Kateřina Bišová
Stable isotopes are used in wide fields of application from natural tracers in biology, geology and archeology through studies of metabolic fluxes to their application as tracers in quantitative proteomics and structural biology. We review the use of stable isotopes of biogenic elements (H, C, N, O, S, Mg, Se) with the emphasis on hydrogen and its heavy isotope deuterium. We will discuss the limitations of enriching various compounds in stable isotopes when produced in living organisms. Finally, we overview methods for measuring stable isotopes, focusing on methods for detection in single cells in situ and their exploitation in modern biotechnologies...
January 17, 2018: Biotechnology Advances
https://www.readbyqxmd.com/read/29355506/diagnostic-accuracy-of-the-veteran-affairs-traumatic-brain-injury-screen
#4
Theresa Louise-Bender Pape, Bridget Smith, Judith Babcock-Parziale, Charlesnika T Evans, Amy A Herrold, Kelly Phipps Maieritsch, Walter M High
OBJECTIVE: To comprehensively estimate the diagnostic accuracy and reliability of the Department of Veterans Affairs (VA) TBI Clinical Reminder Screen (TCRS). DESIGN: Cross-sectional, prospective, observational study using the Standards for Reporting of Diagnostic Accuracy (STARD) criteria. SETTING: Three VA Polytrauma Network Sites. PARTICIPANTS: 433 Operation Iraqi Freedom, Operation Enduring Freedom (OEF/OIF) Veterans...
January 17, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29355335/the-neuroscience-of-cognitive-motivational-styles-sign-and-goal-trackers-as-animal-models
#5
Martin Sarter, Kyra B Phillips
Cognitive-motivational styles describe predominant patterns of processing or biases that broadly influence human cognition and performance. Here we focus on the impact of cognitive-motivational styles on the response to cues predicting the availability of food or addictive drugs. An individual may preferably conduct an analysis of the motivational significance of reward cues, with the result that such cues per se are perceived as rewarding and worth approaching and working for. Alternatively, a propensity for a "cold" analysis of the behavioral utility of a reward cue may yield search behavior for food or drugs but not involve cue approach...
January 22, 2018: Behavioral Neuroscience
https://www.readbyqxmd.com/read/29355311/unexpected-behavior-of-np-in-oxo-selenate-oxo-selenite-systems
#6
Eike M Langer, Olaf Walter, Jean-Yves Colle, Dirk Bosbach, Evgeny V Alekseev
A study of neptunium (Np) chemistry in the complex oxo-selenium system has been performed. Hereby, two sets of precipitation experiments were conducted, investigating the influence of the initial oxidation state of selenium using SeIVO2 and H2SeVIO4 with NpV in alkali nitrate solution, keeping the ratio of Np/Se constant. Surprising results were observed. Five novel neptunium and selenium bearing compounds have been obtained by slow evaporation from aqueous solution. The novel NpIV phase K4-x[Np(SeO3)4-x(HSeO3)x]·(H2O)1...
January 22, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29355281/the-end-of-acquired-immunodeficiency-syndrome-aids-in-singapore-are-we-there-yet
#7
EDITORIAL
Glorijoy Se Tan, Paul A Tambyah
No abstract text is available yet for this article.
December 2017: Annals of the Academy of Medicine, Singapore
https://www.readbyqxmd.com/read/29355130/strategies-of-employees-in-the-construction-industry-to-increase-their-sustainable-employability
#8
Susanne C Tonnon, Rozan van der Veen, Anja Th C M de Kruif, Suzan J W Robroek, Hidde P van der Ploeg, Karin I Proper, Allard J van der Beek
BACKGROUND: The aging work force makes sustainable employability (SE) of workers a priority. However, it is unknown to what extent employees use implemented SE measures. OBJECTIVE: To determine the utilization of 1) SE measures offered by employers, 2) employee SE strategies, and 3) to identify barriers and facilitators of SE strategies. METHODS: Survey data were collected among 731 blue collar and 879 white collar workers to determine the utilization of employer SE measures...
January 19, 2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/29354603/is-the-location-of-the-tumor-another-prognostic-factor-for-patients-with-colon-cancer
#9
Myung-Kyu Jung, Ui Sup Shin, Young-Jun Ki, Yong-Bae Kim, Sun-Mi Moon, Se-Jin Sung
Purpose: In this study, we investigated both the characteristics of right colon cancer (RTCC) in comparison with those of left colon cancer (LTCC) and the impact of the location of the colon cancer on the prognosis. Methods: We retrospectively analyzed the cases of 974 patients with nonmetastatic colon cancer who had undergone surgery with a curative intent from January 2001 to December 2011. RTCC was defined as a tumor located proximal to the splenic flexure. The characteristics of RTCC cancer were investigated by using descriptive analyses, and their impacts on the prognosis were assessed by using a Cox multivariate regression...
December 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/29354389/computer-based-prevention-and-intervention-to-reduce-substance-use-in-youth
#10
Steven Schinke, Traci Marie Schwinn
Purpose of Review: Computer-based programs for substance use prevention and intervention among youth are on the ascendancy. Whether delivered by computer per se or by electronic tablet or smartphone, technology-driven programs are harmonious with how young people access information and interact with their worlds. This review examines recent evidence on computer-based programs aimed at substance use among youth, with particular attention to results from randomized trials. Recent Findings: Outcome studies of computer-based, substance use-related programs published over the past 5 years reveal mixed results amidst diverse intervention approaches and delivery settings...
December 2017: Current Addiction Reports
https://www.readbyqxmd.com/read/29354377/protective-role-of-selenium-against-chromium-stress-involving-metabolites-and-essential-elements-in-brassica-juncea-l-seedlings
#11
Neha Handa, Sukhmeen Kaur Kohli, Ashwani Kumar Thukral, Renu Bhardwaj, Mohammed N Alyemeni, Leonard Wijaya, Parvaiz Ahmad
The present study aimed at the potential role of selenium in providing protection to plants subjected to chromium toxicity. The study was carried out on 15-day-old seedlings of Brassica juncea raised in the solutions of Cr (300 µM) and Se (2, 4 and 6 µM), both alone and in combinations under controlled laboratory environment. The effects were studied on growth, plant metabolites (involved in osmotic homeostasis and stress protection), and essential elements. The results showed that the exposure of B. juncea seedlings to 300 µM Cr led to an increase in the contents of total sugars, reducing sugars, non-reducing sugars, total phenols and flavonoids...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29354241/the-potential-of-diffusion-weighted-magnetic-resonance-imaging-for-predicting-the-outcomes-of-chronic-subdural-hematomas
#12
Seung-Hwan Lee, Jong-Il Choi, Dong-Jun Lim, Sung-Kon Ha, Sang-Dae Kim, Se-Hoon Kim
Objective: Diffusion-weighted magnetic resonance imaging (DW-MRI) has proven useful in the study of the natural history of ischemic stroke. However, the potential of DW-MRI for the evaluation of chronic subdural hematoma (CSDH) has not been established. In this study, we investigated DW-MRI findings of CSDH and evaluated the impact of the image findings on postoperative outcomes of CSDH. Methods: We studied 131 CSDH patients who had undergone single burr hole drainage surgery...
January 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29354239/comparative-analysis-of-spontaneous-infectious-spondylitis-pyogenic-versus-tuberculous
#13
Yangwon Lee, Bum-Joon Kim, Se-Hoon Kim, Seung-Hwan Lee, Won-Hyung Kim, Sung-Won Jin
Objective: Spondylitis is often chemotherapy resistant and requires long-term treatment. Without adequate chemotherapy, the outcome can be fatal or result in severe neurologic damage. Therefore, differentiating the etiology of spondylitis is very important, particularly in spontaneous cases. As the prevalence of tuberculosis in Korea has decreased in recent years, updated clinical research about spondylitis is warranted. Methods: From April 2010 to March 2016, data from spondylitis patients were collected retrospectively...
January 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29354236/gamma-knife-radiosurgery-for-cancer-metastasized-to-the-ocular-choroid
#14
Kyung Rae Cho, Kyung Min Lee, Gyule Han, Se Woong Kang, Jung-Il Lee
Objective: Choroidal metastases (CMs) are the most common intraocular tumor. Management is mainly radiation therapy with goals of pain control and visual improvement. However, many radiation-related complications are reported. Since gamma knife radiosurgery (GKS) for CM was first reported in 1995, few cases have been reported. We report 7 cases of CMs treated with GKS. Methods: From April 2011 to November 2014, 7 patients with CM underwent GKS. Their median age at treatment was 64 years (range, 51-71 years)...
January 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/29354017/modelling-vocabulary-development-among-multilingual-children-prior-to-and-following-the-transition-to-school-entry
#15
Andrea A N MacLeod, Natalie Castellanos-Ryan, Sophie Parent, Sophie Jacques, Jean R Séguin
Differences between monolingual and multilingual vocabulary development have been observed but few studies provide a longitudinal perspective on vocabulary development before and following school entry. This study compares vocabulary growth profiles of 106 multilingual children to 211 monolingual peers before and after school entry to examine whether: (1) school entry coincides with different rates of vocabulary growth compared to prior to school entry, (2) compared to monolingual peers, multilingual children show different vocabulary sizes or rates of vocabulary growth, (3) the age of onset of second-language acquisition for multilingual children is associated with vocabulary size or rate of vocabulary growth, and (4) the sociolinguistic context of the languages spoken by multilingual children is associated with vocabulary size or rate of vocabulary growth...
2018: International Journal of Bilingual Education and Bilingualism
https://www.readbyqxmd.com/read/29353781/age-dependent-changes-in-essential-elements-and-oxidative-stress-biomarkers-in-blood-of-red-deer-and-vulnerability-to-nutritional-deficiencies
#16
Jennifer Pareja-Carrera, Jaime Rodríguez-Estival, Mónica Martinez-Haro, José A Ortiz, Rafael Mateo
Changes in the concentration of circulating essential elements in animals over life may be indicative of periods of vulnerability to deficiencies and associated diseases. Here we studied age-related variations in essential elements (Se, Cu, Zn and Mn) and some selected oxidative stress biomarkers (GPx, SOD, vitamin A and vitamin E) in blood of an Iberian red deer (Cervus elaphus hispanicus) population living in semicaptive conditions. Animals during their first year of life showed to be especially vulnerable to suffer Se- and Cu-related diseases and disorders...
January 16, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29353768/leukocytes-in-peripheral-blood-in-patients-with-bipolar-disorder-trait-and-state-alterations-and-association-with-levels-of-cytokines-and-c-reactive-protein
#17
Klaus Munkholm, Anne Sophie Jacoby, Toke Lenskjold, Helle Bruunsgaard, Maj Vinberg, Lars Vedel Kessing
Low-grade inflammation has been found in patients with bipolar disorder (BD), but rarely assessed using leukocyte counts and findings are limited by lack of control for confounding factors. As a result, it is unclear whether BD per se is associated with peripheral inflammation. We pooled populations from two studies using similar longitudinal designs, including 300 blood samples from a total of 97 patients with BD and 133 blood samples from a total of 72 healthy control individuals (HC). Total leukocyte and neutrophil counts were measured together with interleukin (IL) - 6, IL-8, IL-18, tumor necrosis factor (TNF) - α and high sensitivity C-reactive protein (hsCRP)...
January 11, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29353380/crystal-structure-of-the-nadp-and-tartrate-bound-complex-of-l-serine-3-dehydrogenase-from-the-hyperthermophilic-archaeon-pyrobaculum-calidifontis
#18
Kazunari Yoneda, Haruhiko Sakuraba, Tomohiro Araki, Toshihisa Ohshima
A gene encoding L-serine dehydrogenase (L-SerDH) that exhibits extremely low sequence identity to the Agrobacterium tumefaciens L-SerDH was identified in the hyperthermophilic archaeon Pyrobaculum calidifontis. The predicted amino acid sequence showed 36% identity with that of Pseudomonas aeruginosa L-SerDH, suggesting that P. calidifontis L-SerDH is a novel type of L-SerDH, like Ps. aeruginosa L-SerDH. The overexpressed enzyme appears to be the most thermostable L-SerDH described to date, and no loss of activity was observed by incubation for 30 min at temperatures up to 100 °C...
January 20, 2018: Extremophiles: Life Under Extreme Conditions
https://www.readbyqxmd.com/read/29353302/-diazepam-loading-%C3%A2-can-a-strategy-for-preventing-alcohol-withdrawal-be-used-to-treat-benzodiazepine-use-disorder
#19
Clara Oliveras, Adriana Fortea, Laura Espinosa, Pablo Barrio, Anna Lligoña, Mercè Balcells-Olivero
Las benzodiacepinas se usan para tratar la abstinencia alcohólica siguiendo varias estrategias: dosis descendiente, dosis de carga, tratamiento en función de sintomatología. La carga de diazepam ha demostrado ser un tratamiento válido para la abstinencia alcohólica en ensayos controlados aleatorizados. Tras una búsqueda bibliográfica no sistemática, no hemos encontrado antecedentes en la literatura de una estrategia de carga de diazepam sin posterior administración de benzodiacepinas para el tratamiento de la abstinencia a éstas...
January 15, 2018: Adicciones
https://www.readbyqxmd.com/read/29353169/integrated-biomarkers-response-confirm-the-antioxidant-role-of-diphenyl-diselenide-against-atrazine
#20
Aline Teixeira Marins, Cíntia Côrte Real Rodrigues, Charlene Cavalheiro de Menezes, Jeane de Lima Costa Gomes, Maiara Dorneles Costa, Mauro Eugênio Medina Nunes, Mariela de Souza Vieira, Filipe Fagan Donato, Renato Zanella, Leila Picolli da Silva, Vania Lucia Loro
Atrazine (ATZ) is a herbicide worldwide used. That can cause oxidative damage in non-target organisms, such as fish. Furthermore, the threat of exposure to pesticides together with poor nutrition is hazardous to the normal development of fish, and supplementation of the fish diet with antioxidants compounds is an alternative approach to prevent the hazardous effects of pesticide exposure. Here we aimed to investigate the capacity of diphenyl diselenide (PhSe)2 diet supplementation to improve the antioxidant defense of Cyprinus carpio (carp) exposed to environmental concentrations of ATZ...
January 16, 2018: Ecotoxicology and Environmental Safety
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