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https://www.readbyqxmd.com/read/28454477/in-situ-analysis-of-oxygen-vacancies-and-band-alignment-in-hfo2-tin-structure-for-cmos-applications
#1
Da-Peng Xu, Lin-Jie Yu, Xu-Dong Chen, Lin Chen, Qing-Qing Sun, Hao Zhu, Hong-Liang Lu, Peng Zhou, Shi-Jin Ding, David Wei Zhang
The density of oxygen vacancies characterization in high-k/metal gate is significant for semiconductor device fabrication. In this work, a new approach was demonstrated to detect the density of oxygen vacancies by in situ x-ray photoelectron spectroscopy (XPS) and ultraviolet photoelectron spectroscopy (UPS) measurement. Moreover, the band alignment of the structure with optical band gap measured by spectroscopic ellipsometry (SE) and valence band offset by UPS were reported. The specific areal density of oxygen vacancies in high-k dielectric of HfO2/TiN was obtained by fitting the experiment data to be 8...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28454405/expression-of-b-cell-translocation-gene-2-is-associated-with-favorable-prognosis-in-hepatocellular-carcinoma-patients-and-sensitizes-irradiation-induced-hepatocellular-carcinoma-cell-apoptosis-in-vitro-and-in-nude-mice
#2
Yuanyuan Chen, Chuan Chen, Zhimin Zhang, He Xiao, Bijing Mao, Huan Huang, Chenchen Ding, Lin Lei, Hui Zhang, Jian Li, Mei Jiang, Ge Wang
B-cell translocation gene 2 (BTG2) proteins have been reported to be putative tumor suppressors in various cancer types. The present study first assessed BTG2 expression in 44 human liver cancer tissue specimens, then investigated BTG2 expression in the regulation of hepatocellular carcinoma (HCC) cell apoptosis with or without radiotherapy in vitro and in vivo. The results revealed that BTG2 protein expression was significantly reduced in HCC tissues, and associated with better survival for HCC patients (P=0...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454312/treatment-with-a-selenium-platinum-compound-induced-t-cell-acute-lymphoblastic-leukemia-lymphoma-cells-apoptosis-through-the-mitochondrial-signaling-pathway
#3
Feifei Wu, Wei Cao, Huaping Xu, Mingxia Zhu, Jing Wang, Xiaoyan Ke
T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) is an aggressive hematological disorder that is sensitive to chemotherapy; however, it exhibits frequent relapse rates. Platinum-containing therapeutics are the first-line salvage regimens used in the treatment of relapsed or refractory T-ALL/LBL. The selenium-platinum compound EG-Se/Pt is obtained from the combination of selenium-containing molecules (EG-Se) with cisplatin (CDDP); however, its anticancer properties have been poorly investigated. In the present study, the Cell Counting Kit-8 assay was used to evaluate the inhibitory effect of treatment with EG-Se/Pt on cell viability...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454230/a-subpopulation-of-cancer-stem-cells-identifies-radiographic-characteristics-in-glioblastoma
#4
Ja Eun Kim, Sung Kwon Kim, Jaekyung Shin, Young-Bem Se, Seung Hong Choi, Sung-Hye Park, Seung Ah Choi, Ji Yeoun Lee, Ji Hoon Phi, Kyu-Chang Wang, Chul-Kee Park, Seung-Ki Kim
Cancer stem cells (CSCs), defined by CD133 expression, harbor heterogeneous subpopulations of cells, including endothelial progenitor cells (EPCs). This study aimed to investigate whether a subpopulation of CSCs could affect the radiographic characteristics of glioblastoma. Tissue samples from 10 patients newly diagnosed with glioblastoma were selected according to the radiographic characteristics of their tumors. The patients were divided into two groups based on preoperative magnetic resonance imaging demonstrating contrast enhancement, necrosis and infiltrative patterns: the enhancement/necrosis group (E/N, n=5) and the non-enhancement/infiltration group (NE/I, n=5)...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454022/quantitative-analysis-of-adsorptive-interactions-of-ionic-and-neutral-pharmaceuticals-and-other-chemicals-with-the-surface-of-escherichia-coli-cells-in-aquatic-environment
#5
Chul-Woong Cho, Jeong-Soo Park, Yufeng Zhao, Yeoung-Sang Yun
Since Escherichia coli is ubiquitous in nature and has been applied to biological, chemical, and environmental processes, molecular-level understanding of adsorptive interactions between chemicals and the bacterial surface is of great importance. To characterise the adsorption properties of the surface of E. coli cells in aquatic environment, the binding affinities (log Kd) of calibration compounds were experimentally measured, and then based on the values and numerically well-defined molecular interaction forces, i...
April 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28453990/thermo-chemo-sonic-pre-digestion-of-waste-activated-sludge-for-yeast-cultivation-to-extract-lipids-for-biodiesel-production
#6
P Selvakumar, P Sivashanmugam
The low cost biosynthesis of microbial lipids are an efficient feedstock to replace plant based oil for biodiesel production. The present study objective is to explore the effect of thermo-chemo-sonic pre-digestion of municipal Waste Activated Sludge (WAS) to cultivate oleaginous L. starkeyi MTCC-1400 as a model organism to produce high yield biomass and lipid. Higher Suspended Solids (SS) reduction (20 and 15.71%) and Chemical Oxygen Demand (COD) solubilization (27.6 and 22.3%) were achieved at a Specific Energy (SE) input of 5569 kJ/kg for WAS digested with NaOH and KOH, respectively...
April 25, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28453936/metallic-twin-grain-boundaries-embedded-in-mose2-monolayers-grown-by-molecular-beam-epitaxy
#7
Yujing Ma, Sadhu Kolekar, Horacio Coy Diaz, Johannes Aprojanz, Ilio Miccoli, Christoph Tegenkamp, Matthias Batzill
Twin grain boundaries in MoSe2 are metallic and undergo a metal to insulator Peierls transition at low temperature. Growth of MoSe2 by molecular beam epitaxy results in the spontaneous formation of a high density of these twin grain boundaries, likely as a mechanism to incorporation Se-deficiency in the film. Using scanning tunneling microscopy, we study the grain boundary network that is formed in homoepitaxially grown MoSe2, and for MoSe2 grown heteroepitaxially on MoS2- and HOPG- substrates. No statistically relevant variation of the grain boundary concentration has been found for the different substrates, indicating that the grain boundary formation is substrate independent and depends mainly on the growth conditions...
April 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28453877/asymmetric-changes-in-circulating-insulin-levels-after-an-increase-compared-with-a-reduction-in-insulin-pump-basal-rate-in-people-with-type-1-diabetes
#8
S A McAuley, G M Ward, J C Horsburgh, J L Gooley, A J Jenkins, R J MacIsaac, D N O'Neal
AIMS: To investigate circulating insulin profiles after a clinically relevant insulin pump basal rate increase vs a reduction, and the associated glucose responses. METHODS: A cohort of 12 adults with Type 1 diabetes undertook this two-stage university hospital study using Accu-Chek pumps (Roche Diagnostics, Mannheim, Germany) and insulin aspart. An insulin basal rate change of 0.2 unit/h (increase in first stage, reduction in second stage) was implemented at ~09:30 h, after a single overnight basal rate (without bolus insulin), while fasting participants rested...
April 28, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28453793/impact-of-gender-on-long-term-outcomes-after-surgical-repair-for-acute-stanford-a-aortic-dissection-a-propensity-score-matched-analysis%C3%A2
#9
Anton Sabashnikov, Stephanie Heinen, Antje Christin Deppe, Mohamed Zeriouh, Alexander Weymann, Ingo Slottosch, Kaveh Eghbalzadeh, Aron-Frederik Popov, Oliver Liakopoulos, Parwis B Rahmanian, Navid Madershahian, Axel Kroener, Yeong-Hoon Choi, Ferdinand Kuhn-Régnier, André R Simon, Thorsten Wahlers, Jens Wippermann
OBJECTIVES: Previous research suggests that female gender is associated with increased mortality rates after surgery for Stanford A acute aortic dissection (AAD). However, women with AAD usually present with different clinical symptoms that may bias outcomes. Moreover, there is a lack of long-term results regarding overall mortality and freedom from major cerebrovascular events. We analysed the impact of gender on long-term outcomes after surgery for Stanford A AAD by comparing genders with similar risk profiles using propensity score matching...
May 1, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28453779/first-record-of-lutzomyia-lutzomyia-longipalpis-diptera-psychodidae-phlebotominae-on-the-trinational-frontier-brazil-peru-bolivia-of-south-western-amazonia
#10
Diones Antonio Borges, Silvia Maria Guerra Molina, Mara Cristina Pinto, Eunice Aparecida Bianchi Galati, Manuel Cesario, Dennys Ghenry Samillan Ortiz
Na América do Sul, a principal espécie de flebotomíneo envolvido na transmissão de Leishmania infantum chagasi , agente etiológico da Leishmaniose visceral (VL), é Lutzomyia longipalpis (Lutz & Neiva, 1912). Esta espécie já foi registrada na Colômbia, Venezuela, Bolívia, Argentina, Paraguai, Uruguai e Brasil, onde foram registradas em 24 dos 27 estados brasileiros, com exceção do Acre, Amazonas e Santa Catarina. As coletas foram realizadas por um ano (abril de 2013 a março de 2014) utilizando-se armadilhas de luz tipo de CDC em diferentes ambientes no município de Assis Brasil, estado do Acre...
April 25, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28453774/effect-of-dietary-bacteriophage-supplementation-on-internal-organs-fecal-excretion-and-ileal-immune-response-in-laying-hens-challenged-by-salmonella-enteritidis
#11
P A Adhikari, D E Cosby, N A Cox, J H Lee, W K Kim
With the current researches on replacing antibiotics with different dietary interventions, bacteriophages (BP) are potential antimicrobial intervention because of their ability to affect specific bacteria. A study was conducted to evaluate the role of BP against Salmonella enterica serovar Enteritidis (SE) on SE internal organs colonization and ileum immune response in laying hens. Hens were challenged both orally and intracloacally with 108 cfu/mL cells of nalidixic acid resistant Salmonella Enteritidis (SENAR)...
April 26, 2017: Poultry Science
https://www.readbyqxmd.com/read/28453479/cognitive-domain-dispersion-association-with-alzheimer-s-disease-pathology
#12
Michael Malek-Ahmadi, Sophie Lu, YanYan Chan, Sylvia E Perez, Kewei Chen, Elliott J Mufson
Within neuropsychology, the term dispersion refers to the degree of variation in performance between different cognitive domains for an individual. Previous studies have demonstrated that cognitively normal individuals displaying higher dispersion are at an increased risk for progressing to mild cognitive impairment (MCI) and Alzheimer's disease (AD). Therefore, we determined 1) whether increased dispersion in older adults was associated with amyloid plaques and neurofibrillary tangles (NFTs) and 2) whether increased cognitive dispersion accurately differentiated MCI and AD from non-cognitively impaired (NCI) individuals...
April 28, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28453332/long-term-intermittent-exposure-to-high-altitude-elevates-asymmetric-dimethylarginine-in-first-exposed-young-adults
#13
Nicole Lüneburg, Patricia Siques, Julio Brito, Juan José De La Cruz, Fabiola León-Velarde, Juliane Hannemann, Cristian Ibanez, Rainer H Böger
Lüneburg, Nicole, Patricia Siques, Julio Brito, Juan José De La Cruz, Fabiola León-Velarde, Juliane Hannemann, Cristian Ibanez, and Rainer Böger. Long-term intermittent exposure to high altitude elevates asymmetric dimethylarginine in first exposed young adults. High Alt Med Biol 00:000-000, 2017.-Hypoxia-induced dysregulation of pulmonary and cerebral circulation may be related to an impaired nitric oxide (NO) pathway. We investigated the effect of chronic intermittent hypobaric hypoxia (CIH) on metabolites of the NO pathway...
April 28, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28453246/robust-and-flexible-aramid-nanofiber-graphene-layer-by-layer-electrodes
#14
Se Ra Kwon, Meagan Elinski, James D Batteas, Jodie L Lutkenhaus
Aramid nanofibers (ANFs), or nanoscale Kevlar® fibers, are of interest for its high mechanical performance and functional nanostructure. The dispersible nature of ANFs opens up processing opportunities for creating mechanically robust and flexible nanocomposites, particularly for energy and power applications. The challenge is to manipulate ANFs into an electrode structure that balances mechanical and electrochemical performance to yield a robust and flexible electrode. Here, ANFs and graphene oxide (GO) sheets are blended using layer-by-layer (LbL) assembly to achieve mechanically flexible supercapacitor electrodes...
April 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28448631/biofortification-se-does-it-increase-the-content-of-phenolic-compounds-in-virgin-olive-oil-voo
#15
Roberto D'Amato, Primo Proietti, Andrea Onofri, Luca Regni, Sonia Esposto, Maurizio Servili, Daniela Businelli, Roberto Selvaggini
Extra-Virgin Olive Oil (EVOO) is a fundamental component of the Mediterranean diet and it may contain several anti-oxidant substances, such as phenols. Previous research has shown that this food may be enriched in phenols by spraying a sodium-selenate solution (100 mg L-1 Se) onto the crop canopy before flowering. The aim of this research was to evaluate the effect of this Se-fertilization before flowering (cv. Leccino) on the phenolic profile of EVOOs, and test to what extent such effects depend on the weather pattern, as observed in two contrasting experimental seasons (2013 and 2014)...
2017: PloS One
https://www.readbyqxmd.com/read/28448590/significant-changes-in-circulating-microrna-by-dietary-supplementation-of-selenium-and-coenzyme-q10-in-healthy-elderly-males-a-subgroup-analysis-of-a-prospective-randomized-double-blind-placebo-controlled-trial-among-elderly-swedish-citizens
#16
Urban Alehagen, Peter Johansson, Jan Aaseth, Jan Alexander, Dick Wågsäter
BACKGROUND: Selenium and coenzyme Q10 is essential for important cellular functions. A low selenium intake is reported from many European countries, and the endogenous coenzyme Q10 production is decreasing in the body with increasing age. Supplementation with selenium and coenzyme Q10 in elderly have shown reduced cardiovascular mortality and reduced levels of markers of inflammation. However, microRNA analyses could give important information on the mechanisms behind the clinical effects of supplementation...
2017: PloS One
https://www.readbyqxmd.com/read/28448092/handgrip-strength-predicts-longitudinal-changes-in-clock-drawing-test-performance-an-observational-study-in-a-sample-of-older-non-demented-adults
#17
G Viscogliosi, M G Di Bernardo, E Ettorre, I M Chiriac
OBJECTIVE: Impairment of physical performance might identify older people at higher risk of dementia over time. The present study evaluated handgrip strength as independent predictor of cognitive decline. DESIGN: Observational, prospective. Follow-up duration: 11.2 ± 0.8 months. SETTING AND PARTICIPANTS: Geriatric outpatients center. 104 consecutive stroke- and dementia-free older adults (44% men, ages 80.2 ± 5.4 years). METHODS: The Clinical Dementia Rating scale and the Clock Drawing Test (CDT) were administered...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28448022/development-of-an-economical-dna-delivery-system-by-acufection-and-its-application-to-skin-research
#18
Yu-Jei Lin, Tsung-Lin Lee, Chia-Chi Ku
Dysregulation of immune response in skin is associated with numerous human skin disorders. Direct transfer of immune-related genes into skin tissue is a fascinating approach to investigate immune modulation of cutaneous inflammation in mouse models of human diseases. Here we present a cost-effective protocol that delivered naked DNA in mouse skin and leads to transgene expression. The method is coined "acufection", denoting acupuncture-mediated DNA transfection. To perform acufection, mouse skin was first infused with DNA in phosphate-buffered saline (PBS) and then pricked lightly with a bundle of acupuncture needles to facilitate the absorption of DNA and transfection into cells...
April 19, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447172/selenium-speciation-in-the-fountain-creek-watershed-and-its-effects-on-fish-diversity
#19
James Carsella, Igor Melnykov, Sandra Bonetti, Irma Sánchez-Lombardo, Debbie C Crans
Se is an environmental concern as it can be toxic if present in high concentrations even though it is a dietary requirement for all animals. Se levels are a special concern in the Fountain Creek Watershed located in southeastern Colorado whose geological source is the Se-rich Pierre Shale. Segments of Fountain Creek have Se water levels that exceed the current EPA limit of 5 µg/l. In the studies described here, the effects of river water containing selenium were examined on fish populations at different sites along the Fountain Creek Watershed...
April 26, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/28447132/high-throughput-analysis-of-sub-visible-mab-aggregate-particles-using-automated-fluorescence-microscopy-imaging
#20
Albert Jesuran Paul, Fabian Bickel, Martina Röhm, Lisa Hospach, Bettina Halder, Nina Rettich, René Handrick, Eva Maria Herold, Hans Kiefer, Friedemann Hesse
Aggregation of therapeutic proteins is a major concern as aggregates lower the yield and can impact the efficacy of the drug as well as the patient's safety. It can occur in all production stages; thus, it is essential to perform a detailed analysis for protein aggregates. Several methods such as size exclusion high-performance liquid chromatography (SE-HPLC), light scattering, turbidity, light obscuration, and microscopy-based approaches are used to analyze aggregates. None of these methods allows determination of all types of higher molecular weight (HMW) species due to a limited size range...
April 27, 2017: Analytical and Bioanalytical Chemistry
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